Detailed information for compound 604297

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 422.952 | Formula: C20H31ClN6O2
  • H donors: 0 H acceptors: 4 LogP: 3.56 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCC(c1nnnn1C1CCCCC1)N1CCN(CC1)C(=O)c1ccco1.Cl
  • InChi: 1S/C20H30N6O2.ClH/c1-2-7-17(19-21-22-23-26(19)16-8-4-3-5-9-16)24-11-13-25(14-12-24)20(27)18-10-6-15-28-18;/h6,10,15-17H,2-5,7-9,11-14H2,1H3;1H
  • InChiKey: FDEAAMXHMSWDAI-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Plasmodium falciparum hexose transporter Starlite/ChEMBL No references
Plasmodium falciparum lysine--tRNA ligase Starlite/ChEMBL No references
Plasmodium falciparum calcium-dependent protein kinase 1 Starlite/ChEMBL No references
Plasmodium falciparum (isolate 3D7) Calcium-dependent protein kinase 4 Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Plasmodium falciparum protein kinase 6 Starlite/ChEMBL No references
Leishmania mexicana glucose transporter, lmgt2 Starlite/ChEMBL No references
Plasmodium falciparum protein kinase 7 Starlite/ChEMBL No references
Plasmodium falciparum (isolate 3D7) Proline--tRNA ligase Starlite/ChEMBL No references
Plasmodium falciparum mitogen-activated protein kinase 2 Starlite/ChEMBL No references
Homo sapiens solute carrier family 2 (facilitated glucose transporter), member 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma cruzi hexose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127154 All targets in OG5_127154
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Toxoplasma gondii calcium-dependent protein kinase CDPK3 Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium yoelii cdk-related protein kinase 6-related Get druggable targets OG5_155179 All targets in OG5_155179
Echinococcus granulosus General substrate transporter Get druggable targets OG5_127135 All targets in OG5_127135
Trypanosoma brucei gambiense glucose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Plasmodium knowlesi calcium-dependent protein kinase 4, putative Get druggable targets OG5_126600 All targets in OG5_126600
Trypanosoma congolense lysyl-tRNA synthetase, putative Get druggable targets OG5_126972 All targets in OG5_126972
Entamoeba histolytica prolyl-tRNA synthetase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Leishmania infantum prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Leishmania infantum protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Candida albicans lysyl-tRNA synthetase Get druggable targets OG5_126972 All targets in OG5_126972
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium vivax calcium-dependent protein kinase 1, putative Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium falciparum calcium-dependent protein kinase 3 Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium knowlesi protein kinase 7, putative Get druggable targets OG5_145294 All targets in OG5_145294
Trichomonas vaginalis lysyl-tRNA synthetase, putative Get druggable targets OG5_126972 All targets in OG5_126972
Schistosoma mansoni glucose transport protein Get druggable targets OG5_127135 All targets in OG5_127135
Schistosoma japonicum Calcium/calmodulin-dependent protein kinase type 1, putative Get druggable targets OG5_126600 All targets in OG5_126600
Loa Loa (eye worm) CAMK/CAMK2 protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126972 All targets in OG5_126972
Schistosoma japonicum Calcium/calmodulin-dependent protein kinase type II alpha chain, putative Get druggable targets OG5_126600 All targets in OG5_126600
Leishmania mexicana protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium falciparum protein kinase 7 Get druggable targets OG5_145294 All targets in OG5_145294
Mycobacterium leprae Probable prolyl tRNA synthetase ProS Get druggable targets OG5_127154 All targets in OG5_127154
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127154 All targets in OG5_127154
Trichomonas vaginalis sugar transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Trypanosoma brucei gambiense glucose transporter Get druggable targets OG5_129633 All targets in OG5_129633
Plasmodium berghei protein kinase 7 Get druggable targets OG5_145294 All targets in OG5_145294
Neospora caninum protein kinase, PfPK7 homolog, putative Get druggable targets OG5_145294 All targets in OG5_145294
Plasmodium berghei hexose transporter Get druggable targets OG5_127135 All targets in OG5_127135
Trypanosoma brucei gambiense lysyl-tRNA synthetase, putative Get druggable targets OG5_126972 All targets in OG5_126972
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic Get druggable targets OG5_127154 All targets in OG5_127154
Trypanosoma brucei gambiense hexose transporter,glucose transporter 1B, putative Get druggable targets OG5_129633 All targets in OG5_129633
Plasmodium yoelii putative sugar transporter Get druggable targets OG5_127135 All targets in OG5_127135
Trypanosoma brucei gambiense hexose transporter,glucose transporter 1B Get druggable targets OG5_129633 All targets in OG5_129633
Plasmodium berghei calcium-dependent protein kinase 4 Get druggable targets OG5_126600 All targets in OG5_126600
Theileria parva serine/threonine protein kinase, putative Get druggable targets OG5_145294 All targets in OG5_145294
Echinococcus multilocularis solute carrier family 2 facilitated glucose Get druggable targets OG5_127135 All targets in OG5_127135
Plasmodium yoelii prolyl-tRNA synthetase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Trypanosoma brucei glucose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) Get druggable targets OG5_126972 All targets in OG5_126972
Echinococcus multilocularis lysyl tRNA synthetase Get druggable targets OG5_126972 All targets in OG5_126972
Schistosoma japonicum ko:K07191 MFS transporter, SP family, solute carrier family 2 (facilitated, putative Get druggable targets OG5_127135 All targets in OG5_127135
Echinococcus multilocularis solute carrier family 2 facilitated glucose Get druggable targets OG5_127135 All targets in OG5_127135
Cryptosporidium hominis calmodulin-domain protein kinase 1 Get druggable targets OG5_126600 All targets in OG5_126600
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic Get druggable targets OG5_127154 All targets in OG5_127154
Plasmodium knowlesi mitogen-activated protein kinase 2, putative Get druggable targets OG5_138034 All targets in OG5_138034
Plasmodium berghei calcium-dependent protein kinase 3 Get druggable targets OG5_126600 All targets in OG5_126600
Leishmania infantum lysyl-tRNA synthetase, putative Get druggable targets OG5_126972 All targets in OG5_126972
Trichomonas vaginalis glucose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Plasmodium vivax CDK-related protein kinase 6, putative Get druggable targets OG5_155179 All targets in OG5_155179
Plasmodium vivax hexose transporter Get druggable targets OG5_127135 All targets in OG5_127135
Trypanosoma congolense glucose transporter 2A, putative Get druggable targets OG5_129633 All targets in OG5_129633
Theileria parva calcium-dependent protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) Get druggable targets OG5_127154 All targets in OG5_127154
Leishmania braziliensis glucose transporter/membrane transporter D2, putative Get druggable targets OG5_129633 All targets in OG5_129633
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type Get druggable targets OG5_126600 All targets in OG5_126600
Mycobacterium ulcerans lysyl-tRNA synthetase Get druggable targets OG5_126972 All targets in OG5_126972
Trypanosoma brucei glucose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Neospora caninum hypothetical protein Get druggable targets OG5_126600 All targets in OG5_126600
Echinococcus granulosus lysyl tRNA synthetase Get druggable targets OG5_126972 All targets in OG5_126972
Schistosoma mansoni protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Schistosoma japonicum ko:K04567 lysyl-tRNA synthetase, class II, putative Get druggable targets OG5_126972 All targets in OG5_126972
Trypanosoma brucei glucose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Cryptosporidium parvum calcium/calmodulin dependent protein kinase with a kinas domain and 4 calmodulin-like EF hands Get druggable targets OG5_126600 All targets in OG5_126600
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Trypanosoma cruzi hexose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Neospora caninum Calmodulin-like domain protein kinase isoenzyme gamma, related Get druggable targets OG5_126600 All targets in OG5_126600
Trypanosoma cruzi hexose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Neospora caninum lysyl-tRNA synthetase, putative Get druggable targets OG5_126972 All targets in OG5_126972
Entamoeba histolytica hypothetical protein Get druggable targets OG5_126972 All targets in OG5_126972
Cryptosporidium parvum calcium/calmodulin dependent protein kinase with a kinase domain and 4 calmodulin like EF hands Get druggable targets OG5_126600 All targets in OG5_126600
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX Get druggable targets OG5_126972 All targets in OG5_126972
Leishmania infantum glucose transporter/membrane transporter D2, putative Get druggable targets OG5_129633 All targets in OG5_129633
Leishmania mexicana glucose transporter/membrane transporter D2, putative Get druggable targets OG5_129633 All targets in OG5_129633
Leishmania mexicana prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Leishmania mexicana glucose transporter, lmgt2 Get druggable targets OG5_129633 All targets in OG5_129633
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126600 All targets in OG5_126600
Leishmania major glucose transporter, lmgt3 Get druggable targets OG5_129633 All targets in OG5_129633
Leishmania major lysyl-tRNA synthetase, putative Get druggable targets OG5_126972 All targets in OG5_126972
Leishmania braziliensis glucose transporter, lmgt2 Get druggable targets OG5_129633 All targets in OG5_129633
Chlamydia trachomatis lysine--tRNA ligase Get druggable targets OG5_126972 All targets in OG5_126972
Trypanosoma brucei glucose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Schistosoma japonicum Calcium/calmodulin-dependent protein kinase type II delta chain, putative Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium falciparum proline--tRNA ligase Get druggable targets OG5_127154 All targets in OG5_127154
Cryptosporidium parvum mitogen-activated protein kinase 2, putative Get druggable targets OG5_138034 All targets in OG5_138034
Toxoplasma gondii lysine-tRNA ligase Get druggable targets OG5_126972 All targets in OG5_126972
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Trypanosoma cruzi prolyl-tRNA synthetase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Schistosoma japonicum ko:K01881 prolyl-tRNA synthetase [EC6.1.1.15], putative Get druggable targets OG5_127154 All targets in OG5_127154
Neospora caninum hypothetical protein Get druggable targets OG5_126600 All targets in OG5_126600
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium knowlesi calcium-dependent protein kinase 3, putative Get druggable targets OG5_126600 All targets in OG5_126600
Echinococcus granulosus solute carrier family 2 facilitated glucose Get druggable targets OG5_127135 All targets in OG5_127135
Mycobacterium ulcerans lysyl-tRNA synthetase Get druggable targets OG5_126972 All targets in OG5_126972
Candida albicans hypothetical protein Get druggable targets OG5_127154 All targets in OG5_127154
Candida albicans almost identical to C terminus of CaP19.2425 Get druggable targets OG5_127135 All targets in OG5_127135
Trypanosoma congolense prolyl-tRNA synthetase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Leishmania mexicana glucose transporter, lmgt3 Get druggable targets OG5_129633 All targets in OG5_129633
Brugia malayi Sugar transporter family protein Get druggable targets OG5_127135 All targets in OG5_127135
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 Get druggable targets OG5_126600 All targets in OG5_126600
Trypanosoma brucei glucose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Plasmodium yoelii lysyl-tRNA synthetase Get druggable targets OG5_126972 All targets in OG5_126972
Neospora caninum Glucose transporter 1A, related Get druggable targets OG5_127135 All targets in OG5_127135
Plasmodium knowlesi calcium-dependent protein kinase 1, putative Get druggable targets OG5_126600 All targets in OG5_126600
Trichomonas vaginalis prolyl-tRNA synthetase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Trypanosoma brucei THT1 - hexose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Plasmodium knowlesi lysine--tRNA ligase, putative Get druggable targets OG5_126972 All targets in OG5_126972
Toxoplasma gondii calcium-dependent protein kinase CDPK2A Get druggable targets OG5_126600 All targets in OG5_126600
Leishmania donovani glucose transporter/membrane transporter D2, putative Get druggable targets OG5_129633 All targets in OG5_129633
Leishmania braziliensis lmgt2, putative Get druggable targets OG5_129633 All targets in OG5_129633
Candida albicans C terminus is almost identical to CaP19.2865 Get druggable targets OG5_127135 All targets in OG5_127135
Giardia lamblia Prolyl-tRNA synthetase Get druggable targets OG5_127154 All targets in OG5_127154
Plasmodium knowlesi calcium-dependent protein kinase 5, putative Get druggable targets OG5_126600 All targets in OG5_126600
Trypanosoma brucei gambiense glucose transporter,glucose transporter 2A, putative Get druggable targets OG5_129633 All targets in OG5_129633
Leishmania mexicana lysyl-tRNA synthetase, putative Get druggable targets OG5_126972 All targets in OG5_126972
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium berghei protein kinase 6 Get druggable targets OG5_155179 All targets in OG5_155179
Trichomonas vaginalis lysyl-tRNA synthetase, putative Get druggable targets OG5_126972 All targets in OG5_126972
Leishmania braziliensis lysyl-tRNA synthetase, putative Get druggable targets OG5_126972 All targets in OG5_126972
Schistosoma japonicum IPR005828,General substrate transporter,domain-containing Get druggable targets OG5_127135 All targets in OG5_127135
Plasmodium falciparum calcium-dependent protein kinase 5 Get druggable targets OG5_126600 All targets in OG5_126600
Candida albicans C terminus is almost identical to CaP19.2865 Get druggable targets OG5_127135 All targets in OG5_127135
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127135 All targets in OG5_127135
Plasmodium falciparum mitogen-activated protein kinase 2 Get druggable targets OG5_138034 All targets in OG5_138034
Cryptosporidium parvum proline-tRNA synthetase; class II aaRS (ybak RNA binding domain plus tRNA synthetase) Get druggable targets OG5_127154 All targets in OG5_127154
Trypanosoma congolense glucose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Schistosoma japonicum ko:K04515 calcium/calmodulin-dependent protein kinase (CaM kinase) II, putative Get druggable targets OG5_126600 All targets in OG5_126600
Candida albicans similar to S. cerevisiae YHR020W Get druggable targets OG5_127154 All targets in OG5_127154
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127154 All targets in OG5_127154
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Trypanosoma brucei gambiense protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Echinococcus multilocularis calcium dependent protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Echinococcus granulosus solute carrier family 2 facilitated glucose Get druggable targets OG5_127135 All targets in OG5_127135
Brugia malayi bifunctional aminoacyl-tRNA synthetase Get druggable targets OG5_127154 All targets in OG5_127154
Babesia bovis calcium-dependent protein kinase 4 Get druggable targets OG5_126600 All targets in OG5_126600
Echinococcus granulosus calcium:calmodulin dependent protein kinase type Get druggable targets OG5_126600 All targets in OG5_126600
Schistosoma mansoni protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) Get druggable targets OG5_127154 All targets in OG5_127154
Cryptosporidium parvum calmodulin-domain protein kinase 1, putative Get druggable targets OG5_126600 All targets in OG5_126600
Schistosoma japonicum IPR000924,Glutamyl-tRNA synthetase, class Ic;IPR001412,Aminoacyl-tRNA synthetase, class I,domain-containing Get druggable targets OG5_127154 All targets in OG5_127154
Trypanosoma congolense glucose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Giardia lamblia Lysyl-tRNA synthetase Get druggable targets OG5_126972 All targets in OG5_126972
Echinococcus granulosus calcium:calmodulin dependent protein kinase type Get druggable targets OG5_126600 All targets in OG5_126600
Candida albicans Serine-threonine protein kinase similar to S. cerevisiae CMK2 (YOL016C) calcium/calmodulin-dependent protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Brugia malayi lysyl-tRNA synthetase Get druggable targets OG5_126972 All targets in OG5_126972
Trypanosoma congolense protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type Get druggable targets OG5_126600 All targets in OG5_126600
Echinococcus granulosus solute carrier family 2 facilitated glucose Get druggable targets OG5_127135 All targets in OG5_127135
Plasmodium yoelii Plasmodium falciparum CDPK2 protein Get druggable targets OG5_126600 All targets in OG5_126600
Schistosoma japonicum Solute carrier family 2, facilitated glucose transporter member 3, putative Get druggable targets OG5_127135 All targets in OG5_127135
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type Get druggable targets OG5_126600 All targets in OG5_126600
Schistosoma japonicum Solute carrier family 2, facilitated glucose transporter member 4, putative Get druggable targets OG5_127135 All targets in OG5_127135
Plasmodium falciparum hexose transporter Get druggable targets OG5_127135 All targets in OG5_127135
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) Get druggable targets OG5_126972 All targets in OG5_126972
Schistosoma mansoni glucose transport protein Get druggable targets OG5_127135 All targets in OG5_127135
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_129633 All targets in OG5_129633
Plasmodium falciparum protein kinase 6 Get druggable targets OG5_155179 All targets in OG5_155179
Leishmania major protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX Get druggable targets OG5_126972 All targets in OG5_126972
Leishmania braziliensis protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Neospora caninum Calcium-dependent protein kinase 2, related Get druggable targets OG5_126600 All targets in OG5_126600
Trichomonas vaginalis glucose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Plasmodium yoelii Ser/Thr protein kinase Get druggable targets OG5_145294 All targets in OG5_145294
Schistosoma mansoni protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Leishmania mexicana prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Toxoplasma gondii facilitative glucose transporter GT1 Get druggable targets OG5_127135 All targets in OG5_127135
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Leishmania major glucose transporter, lmgt2 Get druggable targets OG5_129633 All targets in OG5_129633
Loa Loa (eye worm) sugar transporter Get druggable targets OG5_127135 All targets in OG5_127135
Plasmodium yoelii calmodulin-domain protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Trypanosoma brucei glucose transporter 1E Get druggable targets OG5_129633 All targets in OG5_129633
Schistosoma japonicum expressed protein Get druggable targets OG5_127154 All targets in OG5_127154
Plasmodium vivax calcium-dependent protein kinase 3, putative Get druggable targets OG5_126600 All targets in OG5_126600
Leishmania infantum prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Leishmania major glucose transporter, lmgt1 Get druggable targets OG5_129633 All targets in OG5_129633
Schistosoma japonicum ko:K08794 calcium/calmodulin-dependent protein kinase I, putative Get druggable targets OG5_126600 All targets in OG5_126600
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative Get druggable targets OG5_138034 All targets in OG5_138034
Cryptosporidium hominis calcium-dependent protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium berghei mitogen-activated protein kinase 2 Get druggable targets OG5_138034 All targets in OG5_138034
Cryptosporidium hominis Kars protein Get druggable targets OG5_126972 All targets in OG5_126972
Toxoplasma gondii protein kinase, putative Get druggable targets OG5_145294 All targets in OG5_145294
Trichomonas vaginalis sugar transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Schistosoma mansoni lysyl-tRNA synthetase Get druggable targets OG5_126972 All targets in OG5_126972
Plasmodium vivax calcium-dependent protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium knowlesi CDK-related protein kinase 6, putative Get druggable targets OG5_155179 All targets in OG5_155179
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_129633 All targets in OG5_129633
Brugia malayi Bifunctional aminoacyl-tRNA synthetase Get druggable targets OG5_127154 All targets in OG5_127154
Plasmodium falciparum calcium-dependent protein kinase 2 Get druggable targets OG5_126600 All targets in OG5_126600
Leishmania donovani lysyl-tRNA synthetase, putative Get druggable targets OG5_126972 All targets in OG5_126972
Plasmodium vivax calcium-dependent protein kinase 4, putative Get druggable targets OG5_126600 All targets in OG5_126600
Echinococcus multilocularis General substrate transporter Get druggable targets OG5_127135 All targets in OG5_127135
Trypanosoma brucei lysyl-tRNA synthetase, putative Get druggable targets OG5_126972 All targets in OG5_126972
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Leishmania infantum glucose transporter, lmgt2 Get druggable targets OG5_129633 All targets in OG5_129633
Candida albicans Serine-threonine protein kinase similar to S. cerevisiae CMK2 (YOL016C) calcium/calmodulin-dependent protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Schistosoma japonicum Solute carrier family 2, facilitated glucose transporter member 1, putative Get druggable targets OG5_127135 All targets in OG5_127135
Trypanosoma brucei glucose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Trypanosoma brucei glucose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Candida albicans almost identical to C terminus of CaP19.2425 Get druggable targets OG5_127135 All targets in OG5_127135
Trypanosoma brucei THT1 - hexose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Plasmodium yoelii calcium-dept. protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Babesia bovis lysyl-tRNA synthetase Get druggable targets OG5_126972 All targets in OG5_126972
Theileria parva lysyl-tRNA synthetase, putative Get druggable targets OG5_126972 All targets in OG5_126972
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_126600 All targets in OG5_126600
Toxoplasma gondii calcium-dependent protein kinase CDPK2B Get druggable targets OG5_126600 All targets in OG5_126600
Schistosoma mansoni hypothetical protein Get druggable targets OG5_127135 All targets in OG5_127135
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type Get druggable targets OG5_126600 All targets in OG5_126600
Cryptosporidium hominis mitogen-activated protein kinase 2 Get druggable targets OG5_138034 All targets in OG5_138034
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain Get druggable targets OG5_126600 All targets in OG5_126600
Trypanosoma brucei glucose transporter 2A Get druggable targets OG5_129633 All targets in OG5_129633
Trypanosoma cruzi prolyl-tRNA synthetase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Theileria parva prolyl-tRNA synthetase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Trypanosoma brucei THT1 - hexose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Trypanosoma congolense protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Neospora caninum prolyl-tRNA synthetase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase Get druggable targets OG5_127154 All targets in OG5_127154
Plasmodium berghei lysine--tRNA ligase, putative Get druggable targets OG5_126972 All targets in OG5_126972
Neospora caninum hypothetical protein Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium berghei proline--tRNA ligase Get druggable targets OG5_127154 All targets in OG5_127154
Echinococcus granulosus calcium dependent protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Cryptosporidium parvum lysyl-tRNA synthetase (NOB+tRNA synthetase) Get druggable targets OG5_126972 All targets in OG5_126972
Echinococcus multilocularis solute carrier family 2 facilitated glucose Get druggable targets OG5_127135 All targets in OG5_127135
Plasmodium vivax proline--tRNA ligase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Plasmodium vivax mitogen-activated protein kinase 2, putative Get druggable targets OG5_138034 All targets in OG5_138034
Theileria parva calmodulin-domain protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Cryptosporidium parvum calcium/calmodulin dependent protein kinase with a kinase domain and 4 calmodulin like EF hands Get druggable targets OG5_126600 All targets in OG5_126600
Trypanosoma cruzi lysyl-tRNA synthetase, putative Get druggable targets OG5_126972 All targets in OG5_126972
Leishmania major glucose transporter/membrane transporter D2, putative Get druggable targets OG5_129633 All targets in OG5_129633
Plasmodium yoelii calcium-dependent protein kinase-3 Get druggable targets OG5_126600 All targets in OG5_126600
Leishmania donovani glucose transporter 1 Get druggable targets OG5_129633 All targets in OG5_129633
Trypanosoma brucei gambiense prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Plasmodium berghei calcium-dependent protein kinase 5 Get druggable targets OG5_126600 All targets in OG5_126600
Echinococcus granulosus calcium:calmodulin dependent protein kinase type Get druggable targets OG5_126600 All targets in OG5_126600
Echinococcus multilocularis solute carrier family 2, facilitated glucose Get druggable targets OG5_127135 All targets in OG5_127135
Leishmania infantum glucose transporter, lmgt3 Get druggable targets OG5_129633 All targets in OG5_129633
Theileria parva mitogen-activated protein kinase 2, putative Get druggable targets OG5_138034 All targets in OG5_138034
Babesia bovis mitogen-activated protein kinase, putative Get druggable targets OG5_138034 All targets in OG5_138034
Plasmodium falciparum calcium-dependent protein kinase 4 Get druggable targets OG5_126600 All targets in OG5_126600
Candida albicans similar to S. cerevisiae YHR020W Get druggable targets OG5_127154 All targets in OG5_127154
Leishmania donovani protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Trichomonas vaginalis sugar transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Schistosoma japonicum Calcium/calmodulin-dependent protein kinase type II beta chain, putative Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium falciparum lysine--tRNA ligase Get druggable targets OG5_126972 All targets in OG5_126972
Trypanosoma brucei glucose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Echinococcus granulosus solute carrier family 2 facilitated glucose Get druggable targets OG5_127135 All targets in OG5_127135
Leishmania infantum glucose transporter, lmgt1 Get druggable targets OG5_129633 All targets in OG5_129633
Babesia bovis protein kinase domain containing protein Get druggable targets OG5_126600 All targets in OG5_126600
Leishmania donovani glucose transporter 3, putative Get druggable targets OG5_129633 All targets in OG5_129633
Plasmodium yoelii mitogen-activated protein kinase 2 Get druggable targets OG5_138034 All targets in OG5_138034
Trypanosoma cruzi hexose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Neospora caninum CMGC kinase, MAPK family, putative Get druggable targets OG5_138034 All targets in OG5_138034
Schistosoma mansoni lysyl-tRNA synthetase Get druggable targets OG5_126972 All targets in OG5_126972
Plasmodium knowlesi hexose transporter, putative Get druggable targets OG5_127135 All targets in OG5_127135
Plasmodium berghei calcium-dependent protein kinase 1 Get druggable targets OG5_126600 All targets in OG5_126600
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) Get druggable targets OG5_127154 All targets in OG5_127154
Schistosoma mansoni glucose transport protein Get druggable targets OG5_127135 All targets in OG5_127135
Candida albicans lysyl-tRNA synthetase Get druggable targets OG5_126972 All targets in OG5_126972
Plasmodium falciparum calcium-dependent protein kinase 1 Get druggable targets OG5_126600 All targets in OG5_126600
Trypanosoma cruzi hexose transporter Get druggable targets OG5_129633 All targets in OG5_129633
Schistosoma japonicum hypothetical protein Get druggable targets OG5_127154 All targets in OG5_127154
Leishmania mexicana glucose transporter, lmgt1 Get druggable targets OG5_129633 All targets in OG5_129633
Babesia bovis prolyl-tRNA synthetase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Leishmania braziliensis prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Cryptosporidium hominis CDPK2 Get druggable targets OG5_126600 All targets in OG5_126600
Brugia malayi Cam kinase protein 1 Get druggable targets OG5_126600 All targets in OG5_126600
Schistosoma japonicum ko:K07299 MFS transporter, SP family, solute carrier family 2 (facilitated, putative Get druggable targets OG5_127135 All targets in OG5_127135
Cryptosporidium hominis aminoacyl-tRNA synthetase Get druggable targets OG5_127154 All targets in OG5_127154
Plasmodium knowlesi proline--tRNA ligase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Plasmodium vivax lysine--tRNA ligase, putative Get druggable targets OG5_126972 All targets in OG5_126972
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Entamoeba histolytica protein kinase, putative Calcium-dependent protein kinase 4   528 aa 429 aa 26.3 %
Cryptosporidium parvum hypothetical protein Calcium-dependent protein kinase 4   528 aa 463 aa 34.1 %
Trypanosoma congolense protein kinase, putative Calcium-dependent protein kinase 4   528 aa 499 aa 29.3 %
Trypanosoma brucei mitogen-activated protein kinase 5 protein kinase 6 305 aa 338 aa 27.2 %
Neospora caninum CAM kinase, CDPK family, putative Calcium-dependent protein kinase 4   528 aa 463 aa 32.0 %
Trypanosoma cruzi CAMK/CAMKL family protein kinase, putative Calcium-dependent protein kinase 4   528 aa 489 aa 28.8 %
Leishmania donovani protein kinase, putative Calcium-dependent protein kinase 4   528 aa 486 aa 27.4 %
Trypanosoma brucei glucose transporter, putative hexose transporter 504 aa 426 aa 22.3 %
Trypanosoma brucei gambiense protein kinase, putative Calcium-dependent protein kinase 4   528 aa 524 aa 26.7 %
Trypanosoma brucei protein kinase, putative Calcium-dependent protein kinase 4   528 aa 524 aa 26.7 %
Trypanosoma brucei protein lipid droplet kinase (LDK) protein kinase 7 343 aa 310 aa 25.2 %
Cryptosporidium parvum calcium/calmodulin-dependent protein kinase with a kinase domain and 4 calmodulin like EF hands Calcium-dependent protein kinase 4   528 aa 468 aa 35.9 %
Cryptosporidium hominis hypothetical protein Calcium-dependent protein kinase 4   528 aa 463 aa 34.1 %
Babesia bovis mitogen-activated protein kinase, putative Calcium-dependent protein kinase 4   528 aa 427 aa 23.4 %
Trypanosoma cruzi CAMK/CAMKL family protein kinase, putative Calcium-dependent protein kinase 4   528 aa 489 aa 29.0 %
Trypanosoma cruzi CAMK/CAMKL family protein kinase, putative Calcium-dependent protein kinase 4   528 aa 522 aa 25.5 %
Neospora caninum Calcium-dependent protein kinase, related Calcium-dependent protein kinase 4   528 aa 516 aa 35.5 %
Cryptosporidium hominis calmodulin-domain protein kinase 2 Calcium-dependent protein kinase 4   528 aa 468 aa 36.1 %
Leishmania braziliensis protein kinase, putative Calcium-dependent protein kinase 4   528 aa 490 aa 27.3 %
Leishmania infantum protein kinase, putative Calcium-dependent protein kinase 4   528 aa 486 aa 27.4 %
Toxoplasma gondii calcium-dependent protein kinase CDPK6 Calcium-dependent protein kinase 4   528 aa 453 aa 34.0 %
Toxoplasma gondii calcium-dependent protein kinase CDPK9 Calcium-dependent protein kinase 4   528 aa 500 aa 34.2 %
Trypanosoma cruzi CAMK/CAMKL family protein kinase, putative Calcium-dependent protein kinase 4   528 aa 527 aa 25.6 %
Leishmania mexicana protein kinase, putative Calcium-dependent protein kinase 4   528 aa 486 aa 27.2 %
Trypanosoma congolense protein kinase, putative Calcium-dependent protein kinase 4   528 aa 517 aa 27.9 %
Toxoplasma gondii calcium-dependent protein kinase CDPK2 Calcium-dependent protein kinase 4   528 aa 480 aa 36.9 %
Trypanosoma brucei glucose transporter, putative solute carrier family 2 (facilitated glucose transporter), member 1 492 aa 395 aa 23.5 %
Giardia lamblia Kinase, NEK Calcium-dependent protein kinase 4   528 aa 509 aa 19.8 %
Theileria parva calmodulin-domain protein kinase, putative Calcium-dependent protein kinase 4   528 aa 454 aa 31.9 %
Leishmania major protein kinase, putative Calcium-dependent protein kinase 4   528 aa 488 aa 27.5 %
Trypanosoma brucei CAMK/CAMKL family protein kinase, putative Calcium-dependent protein kinase 4   528 aa 524 aa 26.7 %
Cryptosporidium hominis calcium-dependent protein kinase Calcium-dependent protein kinase 4   528 aa 502 aa 29.7 %
Cryptosporidium parvum calcium/calmodulin-dependent protein kinase with a kinase domain and 2 calmodulin-like EF hands Calcium-dependent protein kinase 4   528 aa 501 aa 28.9 %
Theileria parva protein kinase, putative Calcium-dependent protein kinase 4   528 aa 507 aa 27.4 %
Babesia bovis calcium-dependent protein kinase, putative Calcium-dependent protein kinase 4   528 aa 450 aa 30.2 %
Trypanosoma congolense protein kinase, putative Calcium-dependent protein kinase 4   528 aa 509 aa 25.5 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0039 0.0597 0.2648
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0126 0.2253 1
Leishmania major glucose transporter, lmgt1 0.0039 0.0606 0.8651
Schistosoma mansoni sugar transporter 0.0018 0.0201 0.0894
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0201 0.0894
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0012 0.0097 0.0429
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0097 0.0429
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0039 0.0597 0.8517
Loa Loa (eye worm) major facilitator superfamily transporter 0.0018 0.0201 0.0883
Echinococcus granulosus solute carrier family 22 0.0018 0.0201 0.0894
Trypanosoma brucei sugar transporter, putative 0.0018 0.0201 0.2874
Loa Loa (eye worm) hypothetical protein 0.0018 0.0201 0.0883
Onchocerca volvulus 0.0018 0.0201 0.048
Echinococcus multilocularis solute carrier family 22 0.0018 0.0201 0.0894
Loa Loa (eye worm) sugar transporter 0.0018 0.0201 0.0883
Trypanosoma cruzi glucose transporter, putative 0.0018 0.0201 0.2874
Trypanosoma cruzi hexose transporter, putative 0.0039 0.0606 0.8651
Loa Loa (eye worm) hypothetical protein 0.0012 0.0097 0.0423
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0097 0.0429
Trichomonas vaginalis myo-inositol transporter, putative 0.0018 0.0201 0.0894
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0201 0.0894
Trichomonas vaginalis sugar transporter, putative 0.0039 0.0606 0.269
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0201 0.0894
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0039 0.0597 0.0903
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0201 0.0894
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0097 0.0423
Echinococcus multilocularis FTZ F1 alpha 0.0012 0.0097 0.0429
Leishmania major lysyl-tRNA synthetase, putative 0.0028 0.0399 0.5689
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0039 0.0597 0.2617
Brugia malayi major facilitator superfamily protein 0.0018 0.0201 0.0883
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0201 0.0894
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0012 0.0097 0.0423
Loa Loa (eye worm) hypothetical protein 0.0031 0.0448 0.1963
Loa Loa (eye worm) hypothetical protein 0.0028 0.0399 0.1748
Trypanosoma brucei glucose transporter, putative 0.0039 0.0606 0.8651
Onchocerca volvulus 0.0018 0.0201 0.048
Chlamydia trachomatis proline--tRNA ligase 0.0013 0.0119 0.2978
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0038 0.0582 0.2583
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0038 0.0582 1
Schistosoma mansoni lysyl-tRNA synthetase 0.0028 0.0399 0.1769
Toxoplasma gondii facilitative glucose transporter GT1 0.0126 0.2253 0.3408
Plasmodium vivax proline--tRNA ligase, putative 0.0044 0.0701 0.0701
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0038 0.0582 0.2552
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0012 0.0097 0.0429
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0039 0.0597 0.0597
Onchocerca volvulus 0.0018 0.0201 0.048
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0039 0.0597 0.2648
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0018 0.0201 0.0894
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0201 0.0894
Echinococcus granulosus lysyl tRNA synthetase 0.0028 0.0399 0.1769
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0039 0.0597 0.2648
Brugia malayi major facilitator superfamily protein 0.0018 0.0201 0.0883
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0201 0.0894
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0201 0.0894
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0012 0.0097 0.0429
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0201 0.0894
Trypanosoma cruzi sugar transporter, putative 0.0018 0.0201 0.2874
Onchocerca volvulus Putative transporter 0.0018 0.0201 0.048
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0201 0.0894
Entamoeba histolytica hypothetical protein 0.0028 0.0399 0.6679
Schistosoma mansoni serine/threonine protein kinase 0.0039 0.0597 0.2648
Trypanosoma cruzi hexose transporter, putative 0.0018 0.0201 0.2874
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0201 0.0894
Trypanosoma brucei glucose transporter 1E 0.0039 0.0606 0.8651
Onchocerca volvulus 0.0018 0.0201 0.048
Toxoplasma gondii sugar transporter ST3 0.0018 0.0201 0.0305
Mycobacterium ulcerans sugar transporter 0.0018 0.0201 0.5052
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0012 0.0097 0.0423
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0177 0.0774
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0201 0.0894
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0052 0.0848 0.372
Schistosoma mansoni sugar transporter 0.0018 0.0201 0.0894
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0201 0.0894
Schistosoma mansoni lysyl-tRNA synthetase 0.0028 0.0399 0.1769
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0097 0.0423
Treponema pallidum prolyl-tRNA synthetase 0.0013 0.0119 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0097 0.0423
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0028 0.0399 1
Leishmania major hypothetical protein, conserved 0.0018 0.0201 0.2874
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0038 0.0582 0.2552
Loa Loa (eye worm) hypothetical protein 0.0018 0.0201 0.0883
Trichomonas vaginalis sugar transporter, putative 0.0039 0.0606 0.269
Trichomonas vaginalis glucose transporter, putative 0.0039 0.0606 0.269
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0044 0.0701 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0537 0.2356
Loa Loa (eye worm) hypothetical protein 0.0018 0.0201 0.0883
Onchocerca volvulus 0.0018 0.0201 0.048
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0012 0.0097 0.0423
Giardia lamblia Sugar-proton symporter 0.0018 0.0201 0.346
Brugia malayi Major Facilitator Superfamily protein 0.0018 0.0201 0.0883
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0177 0.0774
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0039 0.0597 0.2648
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0012 0.0097 0.0423
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0126 0.2253 1
Plasmodium falciparum calcium-dependent protein kinase 5 0.0039 0.0597 0.0597
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0012 0.0097 0.0429
Plasmodium falciparum calcium-dependent protein kinase 3 0.0039 0.0597 0.0597
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0177 0.0784
Loa Loa (eye worm) hypothetical protein 0.0052 0.0848 0.372
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0097 0.0429
Mycobacterium ulcerans integral membrane transport protein 0.0018 0.0201 0.5052
Toxoplasma gondii transporter, major facilitator family protein 0.0018 0.0201 0.0305
Echinococcus multilocularis solute carrier family 22 0.0018 0.0201 0.0894
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0025 0.0333 0.1477
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0012 0.0097 0.0423
Trichomonas vaginalis sugar transporter, putative 0.0039 0.0606 0.269
Echinococcus granulosus General substrate transporter 0.0108 0.1918 0.851
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0038 0.0582 0.2583
Leishmania major glucose transporter/membrane transporter D2, putative 0.0039 0.0606 0.8651
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0039 0.0597 0.2648
Brugia malayi Steroid receptor seven-up type 2 0.0012 0.0097 0.0423
Trypanosoma brucei THT1 - hexose transporter, putative 0.0039 0.0606 0.8651
Loa Loa (eye worm) hypothetical protein 0.0038 0.0582 0.2552
Leishmania major protein kinase, putative 0.0039 0.0597 0.8517
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0012 0.0097 0.0429
Trypanosoma brucei THT1 - hexose transporter, putative 0.0039 0.0606 0.8651
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0097 0.0423
Brugia malayi hypothetical protein 0.0128 0.2281 1
Schistosoma mansoni protein kinase 0.0039 0.0597 0.2648
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0201 0.0894
Schistosoma mansoni glucose transporter 0.0018 0.0201 0.0894
Onchocerca volvulus 0.0018 0.0201 0.048
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0177 0.0774
Echinococcus multilocularis calcium dependent protein kinase 0.0036 0.0552 0.2448
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0038 0.0582 0.2583
Plasmodium vivax sugar transporter, putative 0.0018 0.0201 0.0201
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0201 0.0894
Echinococcus multilocularis solute carrier family 22 0.0018 0.0201 0.0894
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0012 0.0097 0.0423
Schistosoma mansoni nuclear hormone receptor 0.0012 0.0097 0.0429
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0012 0.0097 0.0429
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0016 0.016 0.07
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0126 0.2253 1
Echinococcus granulosus FTZ F1 alpha 0.0012 0.0097 0.0429
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0126 0.2253 1
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0201 0.0894
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0039 0.0597 0.0903
Schistosoma mansoni hypothetical protein 0.0036 0.0537 0.2385
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0012 0.0097 0.0429
Plasmodium falciparum calcium-dependent protein kinase 4 0.0039 0.0597 0.0597
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0606 0.269
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0201 0.0894
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0201 0.0894
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0028 0.0399 1
Schistosoma mansoni glucose transport protein 0.0126 0.2253 1
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0028 0.0399 0.6849
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0039 0.0597 0.2648
Onchocerca volvulus 0.0018 0.0201 0.048
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0018 0.0201 1
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0018 0.0201 0.6328
Loa Loa (eye worm) hypothetical protein 0.0018 0.0201 0.0883
Trypanosoma brucei glucose transporter, putative 0.0039 0.0606 0.8651
Schistosoma mansoni hypothetical protein 0.0016 0.0177 0.0784
Brugia malayi latrophilin 2 splice variant baaae 0.0036 0.0537 0.2356
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0201 0.0894
Echinococcus granulosus solute carrier family 22 0.0018 0.0201 0.0894
Toxoplasma gondii sugar transporter ST1 0.0018 0.0201 0.0305
Trypanosoma brucei glucose transporter, putative 0.0039 0.0606 0.8651
Plasmodium vivax hexose transporter 0.0126 0.2253 0.2253
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0039 0.0597 0.2617
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0097 0.0429
Loa Loa (eye worm) hypothetical protein 0.0018 0.0201 0.0883
Loa Loa (eye worm) hypothetical protein 0.0012 0.0097 0.0423
Loa Loa (eye worm) major facilitator superfamily transporter 0.0018 0.0201 0.0883
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0039 0.0597 0.0597
Schistosoma mansoni protein kinase 0.0039 0.0597 0.2648
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0012 0.0097 0.0423
Toxoplasma gondii protein kinase, putative 0.0357 0.6612 1
Onchocerca volvulus Huntingtin homolog 0.0128 0.2281 1
Schistosoma mansoni protein kinase 0.0039 0.0597 0.2648
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0201 0.0894
Loa Loa (eye worm) hypothetical protein 0.0012 0.0097 0.0423
Schistosoma mansoni coup transcription factor 0.0012 0.0097 0.0429
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0012 0.0097 0.0429
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0201 0.0894
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0044 0.0701 1
Onchocerca volvulus 0.0018 0.0201 0.048
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0044 0.0701 0.106
Loa Loa (eye worm) hypothetical protein 0.0039 0.0597 0.2617
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0012 0.0097 0.0423
Schistosoma mansoni glucose transport protein 0.0126 0.2253 1
Loa Loa (eye worm) hypothetical protein 0.0128 0.2281 1
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0012 0.0097 0.0429
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0201 0.0894
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.0018 0.0201 0.6328
Brugia malayi hypothetical protein 0.0018 0.0201 0.0883
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0177 0.0784
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0028 0.0399 0.1769
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0052 0.0848 0.372
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0201 0.0894
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0126 0.2253 1
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0038 0.0582 0.2583
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0606 0.269
Loa Loa (eye worm) hypothetical protein 0.0012 0.0097 0.0423
Leishmania major glucose transporter, lmgt2 0.0039 0.0606 0.8651
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0038 0.0582 0.2583
Schistosoma mansoni RAR-like nuclear receptor 0.0012 0.0097 0.0429
Echinococcus granulosus solute carrier family 22 0.0018 0.0201 0.0894
Echinococcus multilocularis synaptic vesicle 2 protein 0.0018 0.0201 0.0894
Trichomonas vaginalis sugar transport protein, putative 0.0018 0.0201 0.0894
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0039 0.0597 0.2617
Echinococcus multilocularis lysyl tRNA synthetase 0.0028 0.0399 0.1769
Onchocerca volvulus 0.0018 0.0201 0.048
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0177 0.0784
Trichomonas vaginalis CAMK family protein kinase 0.0039 0.0597 0.2648
Onchocerca volvulus 0.0018 0.0201 0.048
Trypanosoma cruzi hexose transporter, putative 0.0021 0.027 0.386
Plasmodium vivax calcium-dependent protein kinase, putative 0.0039 0.0597 0.0597
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0201 0.0894
Trypanosoma brucei THT1 - hexose transporter, putative 0.0039 0.0606 0.8651
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0097 0.0423
Brugia malayi nuclear receptor NHR-88 0.0012 0.0097 0.0423
Toxoplasma gondii lysine-tRNA ligase 0.0028 0.0399 0.0603
Loa Loa (eye worm) hypothetical protein 0.0038 0.0582 0.2552
Echinococcus multilocularis solute carrier family 22 0.0018 0.0201 0.0894
Brugia malayi Major Facilitator Superfamily protein 0.0018 0.0201 0.0883
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0012 0.0097 0.0429
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0012 0.0097 0.0423
Onchocerca volvulus 0.0018 0.0201 0.048
Plasmodium falciparum calcium-dependent protein kinase 1 0.0039 0.0597 0.0597
Loa Loa (eye worm) sugar transporter 0.0126 0.2253 0.9881
Loa Loa (eye worm) hypothetical protein 0.0018 0.0201 0.0883
Echinococcus granulosus GPCR family 2 0.0016 0.0177 0.0784
Schistosoma mansoni sugar transporter 0.0018 0.0201 0.0894
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0201 0.0894
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0201 0.0894
Onchocerca volvulus 0.0018 0.0201 0.048
Entamoeba histolytica protein kinase, putative 0.0039 0.0597 1
Plasmodium falciparum lysine--tRNA ligase 0.0028 0.0399 0.0399
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0126 0.2253 1
Trypanosoma cruzi hexose transporter, putative 0.0039 0.0606 0.8651
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0018 0.0201 0.2874
Onchocerca volvulus 0.0018 0.0201 0.048
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0097 0.0429
Leishmania major glucose transporter, lmgt3 0.0039 0.0606 0.8651
Brugia malayi Cam kinase protein 1 0.0039 0.0597 0.2617
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0038 0.0582 0.9752
Brugia malayi Sugar transporter family protein 0.0018 0.0201 0.0883
Trypanosoma brucei glucose transporter, putative 0.0039 0.0606 0.8651
Trypanosoma cruzi hexose transporter 0.0039 0.0606 0.8651
Schistosoma mansoni hypothetical protein 0.0016 0.0177 0.0784
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0039 0.0597 0.0903
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0097 0.0423
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0039 0.0597 0.2648
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0097 0.0423
Brugia malayi steroid hormone receptor 0.0012 0.0097 0.0423
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0201 0.0894
Toxoplasma gondii sugar transporter ST2 0.0018 0.0201 0.0305
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0126 0.2253 1
Echinococcus multilocularis thyroid hormone receptor alpha 0.0012 0.0097 0.0429
Onchocerca volvulus 0.0018 0.0201 0.048
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0012 0.0097 0.0423
Loa Loa (eye worm) hypothetical protein 0.0018 0.0201 0.0883
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0012 0.0097 0.0429
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0201 0.0894
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0201 0.0894
Loa Loa (eye worm) hypothetical protein 0.0018 0.0201 0.0883
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0012 0.0097 0.0423
Loa Loa (eye worm) hypothetical protein 0.0012 0.0097 0.0423
Echinococcus multilocularis ecdysone induced protein 78C 0.0012 0.0097 0.0429
Echinococcus granulosus Sugar transporter ERD6 protein 0.0018 0.0201 0.0894
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0024 0.0318 1
Echinococcus granulosus synaptic vesicle 2 protein 0.0018 0.0201 0.0894
Plasmodium falciparum mitogen-activated protein kinase 2 0.0204 0.3724 0.3724
Loa Loa (eye worm) hypothetical protein 0.0012 0.0097 0.0423
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0018 0.0201 0.0894
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0201 0.0894
Loa Loa (eye worm) hypothetical protein 0.0018 0.0201 0.0883
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0097 0.0423
Schistosoma mansoni sugar transporter 0.0018 0.0201 0.0894
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0201 0.0894
Loa Loa (eye worm) hypothetical protein 0.0128 0.2281 1
Schistosoma mansoni retinoic acid receptor RXR 0.0012 0.0097 0.0429
Giardia lamblia Prolyl-tRNA synthetase 0.0038 0.0582 1
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0028 0.0399 0.5689
Loa Loa (eye worm) hypothetical protein 0.0018 0.0201 0.0883
Plasmodium vivax CDK-related protein kinase 6, putative 0.0536 1 1
Plasmodium falciparum hexose transporter 0.0126 0.2253 0.2253
Loa Loa (eye worm) hypothetical protein 0.0018 0.0201 0.0883
Brugia malayi Major Facilitator Superfamily protein 0.0018 0.0201 0.0883
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0201 0.0894
Trichomonas vaginalis conserved hypothetical protein 0.0126 0.2253 1
Brugia malayi hypothetical protein 0.0018 0.0201 0.0883
Schistosoma mansoni hypothetical protein 0.0016 0.0177 0.0784
Loa Loa (eye worm) hypothetical protein 0.0018 0.0201 0.0883
Trypanosoma brucei glucose transporter, putative 0.0039 0.0606 0.8651
Schistosoma mansoni glucose transport protein 0.0126 0.2253 1
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0018 0.0201 0.5052
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0201 0.0894
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0201 0.0894
Brugia malayi photoreceptor-specific nuclear receptor 0.0012 0.0097 0.0423
Trypanosoma cruzi hexose transporter, putative 0.0039 0.0606 0.8651
Brugia malayi Calcitonin receptor-like protein seb-1 0.0052 0.0848 0.372
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0177 0.0784
Giardia lamblia Hexose transporter 0.0018 0.0201 0.346
Chlamydia trachomatis lysine--tRNA ligase 0.0028 0.0399 1
Echinococcus granulosus calcium dependent protein kinase 0.0036 0.0552 0.2448
Echinococcus granulosus ecdysone induced protein 78C 0.0012 0.0097 0.0429
Plasmodium falciparum proline--tRNA ligase 0.0044 0.0701 0.0701
Trichomonas vaginalis glucose transporter, putative 0.0039 0.0606 0.269
Brugia malayi lysyl-tRNA synthetase 0.0028 0.0399 0.1748
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0044 0.0701 1
Mycobacterium ulcerans prolyl-tRNA synthetase 0.0013 0.0119 0.2978
Brugia malayi nuclear hormone receptor 0.0012 0.0097 0.0423
Loa Loa (eye worm) hypothetical protein 0.0016 0.0177 0.0774
Schistosoma mansoni hypothetical protein 0.0126 0.2253 1
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0012 0.0097 0.0423
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0201 0.0894
Schistosoma mansoni hypothetical protein 0.0016 0.0177 0.0784
Echinococcus multilocularis GPCR, family 2 0.0016 0.0177 0.0784
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0012 0.0097 0.0423
Trypanosoma brucei glucose transporter 2A 0.0039 0.0606 0.8651
Brugia malayi Sugar transporter family protein 0.0018 0.0201 0.0883
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0201 0.0894
Plasmodium vivax lysine--tRNA ligase, putative 0.0028 0.0399 0.0399
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0201 0.0894
Trypanosoma brucei glucose transporter, putative 0.0039 0.0606 0.8651
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0204 0.3724 0.3724
Brugia malayi ecdysteroid receptor 0.0012 0.0097 0.0423
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0039 0.0597 0.2648
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0044 0.0701 1
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0039 0.0597 0.0597
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0018 0.0201 0.5052
Schistosoma mansoni steroid hormone receptor ad4bp 0.0012 0.0097 0.0429
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0012 0.0097 0.0429
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0201 0.0894
Trichomonas vaginalis glucose transporter, putative 0.0018 0.0201 0.0894
Trypanosoma brucei glucose transporter, putative 0.0039 0.0606 0.8651
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0012 0.0097 0.0429
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0044 0.0701 1
Onchocerca volvulus 0.0018 0.0201 0.048
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0024 0.0318 1
Echinococcus granulosus solute carrier family 22 0.0018 0.0201 0.0894
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0012 0.0097 0.0429
Entamoeba histolytica protein kinase, putative 0.0039 0.0597 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0097 0.0423
Plasmodium falciparum protein kinase 7 0.0357 0.6612 0.6612
Trypanosoma brucei glucose transporter, putative 0.0039 0.0606 0.8651
Echinococcus multilocularis General substrate transporter 0.0108 0.1918 0.851
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0097 0.0429
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0204 0.3724 0.5632
Plasmodium falciparum calcium-dependent protein kinase 2 0.0039 0.0597 0.0597
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0201 0.0894
Onchocerca volvulus 0.0018 0.0201 0.048
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0126 0.2253 1
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0201 0.0894
Leishmania major myo-inositol/proton symporter (MIT) 0.0018 0.0201 0.2874
Loa Loa (eye worm) steroid hormone receptor 0.0012 0.0097 0.0423
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0018 0.0201 0.0201
Onchocerca volvulus Huntingtin homolog 0.0128 0.2281 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0201 0.0883
Giardia lamblia Lysyl-tRNA synthetase 0.0028 0.0399 0.6849
Loa Loa (eye worm) hypothetical protein 0.0018 0.0201 0.0883
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0028 0.0399 0.5689
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0012 0.0097 0.0423
Loa Loa (eye worm) hypothetical protein 0.0018 0.0201 0.0883
Brugia malayi Sugar transporter family protein 0.0126 0.2253 0.9881
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0024 0.0318 0.5469
Brugia malayi hypothetical protein 0.0018 0.0201 0.0883
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0012 0.0097 0.0429

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) NOVARTIS: Antimalarial liver stage activity measured as a greater than 50% reduction in Plasmodium yoelii schizont area in HepG2-A16-CD81 cells at 10uM compound concentration, determined by immuno-fluorescence. ChEMBL. 22096101
CC50 (functional) > 100 uM Huh7 cytotoxicity for Pf inhibitors Novartis-GNF Malaria Box. No reference
CC50 > 100 uM NOVARTIS: Cytotoxicity against human hepatocellular carcinoma cell line (Huh7) ChEMBL. 18579783
EC50 (functional) = 0.616 uM W2 Pf proliferation inhibition Novartis-GNF Malaria Box. No reference
EC50 (functional) = 0.616 uM NOVARTIS: Inhibition of Plasmodium falciparum W2 (drug-resistant) proliferation in erythrocyte-based infection assay ChEMBL. 18579783
EC50 (functional) = 1.333 uM PF proliferation inhibition 3D7 Novartis-GNF Malaria Box. No reference
EC50 (functional) = 1.333 uM NOVARTIS: Inhibition of Plasmodium falciparum 3D7 (drug-susceptible) proliferation in erythrocyte-based infection assay ChEMBL. 18579783
Growth Inhibition (functional) = 10.3688 % MMV: Measure of pLDH activity as indication of parasite viability. Gametocytogenesis of 3D7 Plasmodium falciparum strain was induced in vitro and asexual parasites were depleted with N-acetylglucosamine. Gametocytes were treated with dihydroartemisinin, epoxomicin, methylene blue, primaquine, puromycin or chloroquine in 96-well plates and the pLDH activity was evaluated using a modified Makler protocol. Mosquito infectivity was measured by the standard membrane feeding assay. ChEMBL. No reference
IC50 (functional) = 518.3 nM MMV: IC50 determined against P. falciparum Dd2-luc strain using a Malaria Sybr Green I Fluorescence assay. Starting conditions were 1% trophozoite synchronised parasites at 2% haematocrit. Fluorescence detection completed after 48hr incubation at 37 degrees C under 1% O2, 3% CO2 and balance N2. ChEMBL. No reference
IC50 (functional) > 12000 nM ST_JUDE_LEISH: Cytotoxicity against transgenic Leishmania Mexicana promastigotes LmPfHT that are glucose transport deficient and complemented with the Plasmodium falciparum hexose transporter. Activity is measured by by DNA content using SYBR green in vitro ChEMBL. No reference
IC50 (functional) > 12000 nM ST_JUDE_LEISH: Cytotoxicity against transgenic Leishmania Mexicana promastigotes LmGT2 that are glucose transport deficient and complemented with the L. Mexicana glucose transporter 2. Activity is measured by by DNA content using SYBR green in vitro ChEMBL. No reference
IC50 (functional) > 12000 nM ST_JUDE_LEISH: Cytotoxicity against transgenic Leishmania Mexicana promastigotes LmGLUT1 that are glucose transport deficient and complemented with the human glucose transporter GLUT1. Activity is measured by DNA content using SYBR green in vitro ChEMBL. No reference
IC50 (functional) > 1 uM MMV: MAP2K Protein kinase inhibition assay using recombinant PfMAP2K, protein substrate, ATP and KinaseGlo to measure % inhibition at 1 uM MMV box compound. Final concentrations were 1 uM ATP, 0.5 mM DTT, 1 mM MgCl2, 0.5 mg/mL BSA, and 10 ug/ml MAP2 in a buffer of 50 mM HEPES (pH 7.0). 0.5 mg/mL histone III-S served as the substrate (13); 100 uM AMP-PNP, an ATP analog, was used as a control inhibitor. Incubation time was 4 hours. ChEMBL. No reference
IC50 (functional) > 1 uM MMV: PK6 Protein kinase inhibition assay using recombinant PfPK6, Myelin Basic Protein (MBP) substrate, ATP and KinaseGlo to measure % inhibition at 1 uM MMV box compound. Final concentrations were 1.5 uM ATP, 5 mM MnCl2, and 15 ug/ml PK6 in a buffer of 100 mM Tris-HCl (pH 7.5). 50 ug/mL MBP was provided as the substrate; 10 uM staurosporine was used as a control inhibitor. Incubation time was 3 hours and 40 minutes.The catalytic activity of each kinase was considered proportional to ATP consumed, as determined from measurements of residual [ATP] with the luciferase-based reagent Kinase-Glo (Promega) following incubation. Luminescence (proportional to residual [ATP]) was measured on the plate readers FLx800 (BioTek Instruments, Winooski, VT, USA) and MicroBeta2. ChEMBL. No reference
IC50 (functional) > 1 uM MMV: CDPK1 Protein kinase inhibition assay using recombinant PfCDPK1, syntide 2 peptide substrate, ATP and KinaseGlo to measure % inhibition at 1 uM MMV box compound. ChEMBL. No reference
IC50 (functional) > 1 uM MMV: PK7 Protein kinase inhibition assay using recombinant PfPK7, ATP and KinaseGlo to measure % inhibition at 1 uM MMV box compound. Final concentrations were 1 uM ATP, 2 mM DTT, 20 mM MgCl2, 2 mM MnCl2, 0.01% BSA, and 6 ug/ml PK7, in a buffer of 20 mM Tris-HCl (pH 7.5). The enzyme itself was the only substrate present (since autophosphorylation occurs); 100 uM 1NA-PP1 was used as a control inhibitor. Incubation time was 3 hours. ChEMBL. No reference
IC50 (functional) > 1 uM MMV: CDPK4 Protein kinase inhibition assay using recombinant PfCDPK4, syntide2 peptide substrate, ATP and KinaseGlo to measure % inhibition at 1 uM MMV box compound. ChEMBL. No reference
IC50 (functional) > 2.5 uM MMV: ProRS recombinant Plasmodium falciparum Prolyl-tRNA-synthetase, assay with yeast tRNA, ATP, and proline and 3 uM MMV malaria box compound, assay read out with kinase glo as % inhibition. ChEMBL. No reference
IC50 (functional) > 2.5 uM MMV: KRS recombinant Plasmodium falciparum Lysyl-tRNA-synthetase, assay with yeast tRNA, ATP, and lysine and 3 uM MMV malaria box compound, assay read out with kinase glo as % inhibition. ChEMBL. No reference
IC50 (functional) > 30 uM MMV: Primary screening was performed with each compound at a 30 uM final concentration and in triplicate in sealed 96-well polystyrene microtiter plates. Parasite inocula (100 ul) comprising 20000 parasites/ml were added to each well and grown at 37 degrees C in a humidified atmosphere of 5% CO2 for 72 h. Positive controls consisted of metronidazole at 1 mg/ml. The growth of E. histolytica trophozoites in each well was determined microscopically by measuring the diameters of the confluent cells in drug-containing wells relative to those in the nega- tive-control wells. ChEMBL. No reference
IC50 (functional) > 30 uM MMV: A total of 100ul of inoculum was added to each well (parasite/cell ratio, ~10:1; final volume, 200 ul). Six hours after inoculation, nonadherent parasites were removed, and 100 ul of complete DMEM (1% penicillin-streptomycin, 3% FBS) supplemented with inhibitors at different concentrations (2-fold serial dilutions starting from 30 uM) was added to all except the negative-control wells. Positive controls, consisting of pyrimethamine (PYR) and sulfadiazine (SDZ) (20-mg/ml stocks in DMSO), were tested at a 2mg/ml final concentration. Each test was performed in triplicate. ChEMBL. No reference
IC50 (functional) > 32 uM MMV: Inhibition of Leishmania infantum (MHOM/MA/BE/67) in vitro. ChEMBL. No reference
IC50 > 32 uM MMV: Cytotoxicity against human fibroblasts (MRC-5) cells. ChEMBL. No reference
IC50 (functional) > 32 uM MMV: Inhibition of Trypanosoma cruzi (Tulahuen C4 LacZ) (Chagas in vitro). ChEMBL. No reference
IC50 (functional) > 32 uM MMV: Inhibition of Trypanosoma brucei brucei (Squib 427) (HAT in vitro). ChEMBL. No reference
IC50 (functional) > 32 uM MMV: Inhibition of Trypanosoma brucei rhodesiense (STIB 900) (HAT in vitro). ChEMBL. No reference
IFI promiscuity index = 0 IFI promiscuity index Novartis-GNF Malaria Box. No reference
Inhibition (functional) = -55.52127149013473 % MMV: Cryptosporidium parvum oocysts (Iowa Strain) were prepared for use by treatment with 10 mM HCl (37 degrees C, 10 min) followed by 2 mM sodium taurocholate in phosphate-buffered saline (PBS) with Ca2+ and Mg2+ (16 degrees C, 10 min) in order to stimulate excystation. The high-throughput screen was carried out by inoculating >90% confluent human ileocecal adenocarcinoma (HCT-8) cells (ATCC) with ~5.5 x 10^3 primed oocysts per well. Experimental compounds or DMSO (vehicle) were added three hours after infection, and cells were incubated for 48 hours. ChEMBL. No reference
Inhibition (functional) = -55.5212714901347 % MMV: Cryptosporidium parvum oocysts (Iowa Strain) were prepared for use by treatment with 10 mM HCl (37 degrees C, 10 min) followed by 2 mM sodium taurocholate in phosphate-buffered saline (PBS) with Ca2+ and Mg2+ (16 degrees C, 10 min) in order to stimulate excystation. The high-throughput screen was carried out by inoculating >90% confluent human ileocecal adenocarcinoma (HCT-8) cells (ATCC) with ~5.5 x 10^3 primed oocysts per well. Experimental compounds or DMSO (vehicle) were added three hours after infection, and cells were incubated for 48 hours. ChEMBL. No reference
Inhibition (functional) = -48.4846623858131 % MMV: P. falciparum NF54 functionally mature Stage V gametocytes were incubated for 24 hr in the presence of the test compounds. Gamete formation was then triggered by addition of 2uM xantheurenic acid and temperature decrease to ~20C. Female gamete formation was recorded 24 hr later by automated microscopy detection of surface labelling of female gametes with a Cy3-conjugated antibody reactive to Pfs25. All compounds were tested in 4 independent experiments and data presented here is the mean. ChEMBL. No reference
Inhibition (functional) = -10.2109368813075 % MMV: P. berghei-infected blood was withdrawn from mice by cardiac pucture before being immediately added to ookinete culture medium containing test compounds. 26 hr later, GFP-positive ookinetes were identified and counted by automated microscopy. All compounds were tested in 4 independent experiments and data presented here is the mean. ChEMBL. No reference
Inhibition (functional) = -10.21093688130745 % MMV: P. berghei-infected blood was withdrawn from mice by cardiac pucture before being immediately added to ookinete culture medium containing test compounds. 26 hr later, GFP-positive ookinetes were identified and counted by automated microscopy. All compounds were tested in 4 independent experiments and data presented here is the mean. ChEMBL. No reference
Inhibition (functional) = 3 % MMV: Malaria Box compounds were tested for inhibition of the human ether a go-go related gene (hERG), Kv11.1 channel, using IonWorks 384-well patch clamp electrophysiology at 1.1uM (3 independent assay plates up to 12 cells per concentration). ChEMBL. No reference
Inhibition (functional) = 5.57 % MMV: Screen against Mtb, single point, non replicating, at 25uM ChEMBL. No reference
Inhibition (functional) = 20.4 % MMV: Screen against Mtb, single point, replicating, at 25uM ChEMBL. No reference
Inhibition (functional) = 23.7054943527552 % MMV: P. falciparum NF54 functionally mature Stage V gametocytes were incubated for 24 hr in the presence of the test compounds. Gamete formation was then triggered by addition of 2uM xantheurenic acid and temperature decrease to ~20C. Male gamete exflagellation was recorded and analysed by automated microscopy after 20 min. All compounds were tested in 4 independent experiments and data presented here is the mean. ChEMBL. No reference
Inhibition (functional) = 52 % MMV: Malaria Box compounds were tested for inhibition of the human ether a go-go related gene (hERG), Kv11.1 channel, using IonWorks 384-well patch clamp electrophysiology at 11.1uM (3 independent assay plates up to 12 cells per concentration). ChEMBL. No reference
Inhibition (functional) = 82 % MMV: Inhibition of Plasmodium falciparum 3D7 at 5uM compound concentration. ChEMBL. No reference
Potency (functional) = 0.5012 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 2.6169 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 3.6964 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 23.1093 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 56.2341 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Ratio (functional) = 1.02307692307692 MMV: Compounds (1uM) were screened in a 72hr growth assay monitored by flow cytometry both in the presence and absence of supplemental isopentenyl pyrophosphate (IPP) 200uM. Compounds which fail to show anti-malarial activity when chemically rescued by IPP are therefore specific to the apicoplast. The values are expressed as the ratio of the corresponding activity with and without IPP, respectively. ChEMBL. No reference
Relative Growth (functional) = -0.0604 MMV: Growth assays were conducted using the prototrophic S. cerevisiae strain JHY222. Each MMV compound (0.1 mM) was tested in rich media containing dextrose as a carbon source (Yeast Extract, Peptone, Dextrose; YPD). The growth rate in the presence of each MMV compound was calculated as follows: (i) the first 10 OD readings were averaged and subtracted from all OD readings of the corresponding curve to set the baseline of the growth curve to zero, and (ii) the area under the curve (AUC) was then calculated as the sum of all OD readings. AUC was calculated following 80 OD readings corresponding to roughly 20 h of growth. A relative growth value was calculated as follows: AUC(DRUG) - AUC(DMSO)/AUC(DMSO); where AUC(DMSO) represents growth measured in a DMSO control well that was on the same microtiter plate of the drug-treated culture. A relative growth value near zero means the compound had little or no effect on growth, whereas a value near -1 means the compound strongly or completely inhibited growth. ChEMBL. No reference
Relative Growth (functional) = 0.0167 MMV: Growth assays were conducted using the prototrophic S. cerevisiae strain JHY222. Each MMV compound (0.1 mM) was tested in minimal media containing ethanol and glycerol as carbon sources (Yeast Nitrogen Base, Ethanol, Glycerol; YNBEG). The growth rate in the presence of each MMV compound was calculated as follows: (i) the first 10 OD readings were averaged and subtracted from all OD readings of the corresponding curve to set the baseline of the growth curve to zero, and (ii) the area under the curve (AUC) was then calculated as the sum of all OD readings. AUC was calculated following 180 OD readings, corresponding to roughly 45 h of growth. A relative growth value was calculated as follows: AUC(DRUG) - AUC(DMSO)/AUC(DMSO); where AUC(DMSO) represents growth measured in a DMSO control well that was on the same microtiter plate of the drug-treated culture. A relative growth value near zero means the compound had little or no effect on growth, whereas a value near -1 means the compound strongly or completely inhibited growth. ChEMBL. No reference
Relative Growth (functional) = 0.0714 MMV: Growth assays were conducted using the prototrophic S. cerevisiae strain JHY222. Each MMV compound (0.1 mM) was tested in minimal media containing dextrose as a carbon source (Yeast Nitrogen Base, Dextrose; YNBD). The growth rate in the presence of each MMV compound was calculated as follows: (i) the first 10 OD readings were averaged and subtracted from all OD readings of the corresponding curve to set the baseline of the growth curve to zero, and (ii) the area under the curve (AUC) was then calculated as the sum of all OD readings. AUC was calculated following 80 OD readings, corresponding to roughly 20 h of growth. A relative growth value was calculated as follows: AUC(DRUG) - AUC(DMSO)/AUC(DMSO); where AUC(DMSO) represents growth measured in a DMSO control well that was on the same microtiter plate of the drug-treated culture. A relative growth value near zero means the compound had little or no effect on growth, whereas a value near -1 means the compound strongly or completely inhibited growth. ChEMBL. No reference
Toxicity (functional) = 0 MMV: Toxicity @ 2.5 uM to newly transformed Schistosoma mansoni somules after 72 h on a scale of 0 (none) - 4 (most) as judged visually: includes short descriptors of effects (PMID:19597541). Caffrey group UCSF. ChEMBL. No reference
Toxicity (functional) = 0 MMV: Toxicity @ 2.5 uM to newly transformed Schistosoma mansoni somules after 24 h on a scale of 0 (none) - 4 (most) as judged visually: includes short descriptors of effects (PMID:19597541). Caffrey group UCSF. ChEMBL. No reference
Toxicity (functional) = 0 MMV: Toxicity @ 2.5 uM to newly transformed Schistosoma mansoni somules after 48 h on a scale of 0 (none) - 4 (most) as judged visually: includes short descriptors of effects (PMID:19597541). Caffrey group UCSF. ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23 18579783

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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