Detailed information for compound 61357

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 292.349 | Formula: C16H21FN2O2
  • H donors: 1 H acceptors: 2 LogP: 3.39 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: C[C@@H](NC(=O)C(C(C)(C)C)C#N)COc1ccc(cc1)F
  • InChi: 1S/C16H21FN2O2/c1-11(10-21-13-7-5-12(17)6-8-13)19-15(20)14(9-18)16(2,3)4/h5-8,11,14H,10H2,1-4H3,(H,19,20)/t11-,14?/m1/s1
  • InChiKey: QMFJMSKRWORECV-YNODCEANSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Magnaporthe oryzae (strain 70-15 / FGSC 8958) (Rice blast fungus)(Pyricularia oryzae) Scytalone dehydratase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii prenyltransferase and squalene oxidase repeat-containing protein 0.0287 0.1243 0.2847
Brugia malayi Fli-1 protein 0.0221 0.0914 0.1315
Brugia malayi hypothetical protein 0.0051 0.007 0.01
Schistosoma mansoni neuropeptide F-like receptor 0.0042 0.0025 0.0036
Loa Loa (eye worm) calpain family protein 1 0.0054 0.0082 0.0118
Echinococcus multilocularis metallo beta lactamase domain containing protein 0.0051 0.007 0.007
Trichomonas vaginalis A-type flavoprotein 0.0051 0.007 0.0163
Trypanosoma brucei C-8 sterol isomerase, putative 0.0174 0.0679 0.1321
Loa Loa (eye worm) hypothetical protein 0.0042 0.0025 0.0036
Loa Loa (eye worm) fli-1 protein 0.0221 0.0914 0.1315
Schistosoma mansoni myosin xvIII 0.0042 0.0025 0.0036
Echinococcus multilocularis Squalene phytoene synthase 0.0229 0.0954 0.0954
Echinococcus multilocularis serotonin receptor 0.0042 0.0025 0.0025
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.0056 0.0094 0.0094
Loa Loa (eye worm) prenyltransferase and squalene oxidase repeat family protein 0.0622 0.2907 0.4182
Schistosoma mansoni gabp alpha 0.0073 0.0177 0.0255
Treponema pallidum ribonuclease Z 0.0051 0.007 0.5
Entamoeba histolytica metallo-beta-lactamase family protein 0.0051 0.007 0.0163
Brugia malayi Hypothetical RING finger protein F54G8.4 in chromosome III 0.0038 0.0001 0.0002
Brugia malayi hypothetical protein 0.0042 0.0025 0.0036
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0042 0.0025 0.0036
Echinococcus granulosus hydroxyacylglutathione hydrolase 0.0051 0.007 0.007
Echinococcus multilocularis microtubule associated protein 2 0.0675 0.317 0.317
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0042 0.0025 0.0036
Entamoeba histolytica Rab geranylgeranyltransferase alpha subunit, putative 0.0394 0.1772 0.414
Brugia malayi Melatonin receptor type 1A 0.0042 0.0025 0.0036
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0042 0.0025 0.0036
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0044 0.0044
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0174 0.0679 0.1204
Echinococcus granulosus rhodopsin orphan GPCR 0.0042 0.0025 0.0025
Loa Loa (eye worm) hypothetical protein 0.0042 0.0025 0.0036
Schistosoma mansoni growth hormone secretagogue receptor 0.0042 0.0025 0.0036
Plasmodium vivax geranylgeranyl transferase type2 beta subunit, putative 0.0287 0.1243 0.2847
Mycobacterium tuberculosis Conserved hypothetical protein 0.0051 0.007 0.0133
Brugia malayi hypothetical protein 0.0042 0.0025 0.0036
Loa Loa (eye worm) hypothetical protein 0.0054 0.0082 0.0118
Giardia lamblia Hydroxyacylglutathione hydrolase 0.0051 0.007 0.016
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0151 0.0563 0.0563
Brugia malayi hypothetical protein 0.0433 0.1968 0.2831
Echinococcus granulosus rhodopsin orphan GPCR 0.0042 0.0025 0.0025
Toxoplasma gondii prenyltransferase and squalene oxidase repeat-containing protein 0.0898 0.428 1
Loa Loa (eye worm) hypothetical protein 0.0069 0.0156 0.0224
Echinococcus granulosus neuropeptide receptor A26 0.0042 0.0025 0.0025
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0042 0.0025 0.0025
Schistosoma mansoni neuropeptide receptor 0.0042 0.0025 0.0036
Loa Loa (eye worm) hypothetical protein 0.0062 0.0124 0.0179
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.007 0.0163
Entamoeba histolytica alkyl sulfatase, putative 0.0051 0.007 0.0163
Loa Loa (eye worm) hypothetical protein 0.0042 0.0025 0.0036
Echinococcus multilocularis ETHE1 protein 0.0051 0.007 0.007
Echinococcus granulosus geranylgeranyl transferase type 2 subunit alpha 0.0394 0.1772 0.1772
Giardia lamblia Histone acetyltransferase GCN5 0.0041 0.0016 0.0035
Loa Loa (eye worm) peptidase family M13 containing protein 0.0069 0.0156 0.0224
Loa Loa (eye worm) hypothetical protein 0.0042 0.0025 0.0036
Brugia malayi putative neuropeptide receptor 0.0042 0.0025 0.0036
Echinococcus granulosus g protein coupled receptor 0.0042 0.0025 0.0025
Echinococcus granulosus somatostatin receptor 0.0042 0.0025 0.0025
Loa Loa (eye worm) metallo-beta-lactamase superfamily protein 0.0051 0.007 0.01
Echinococcus granulosus rhodopsin orphan GPCR 0.0042 0.0025 0.0025
Brugia malayi Serotonin receptor 0.0042 0.0025 0.0036
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0065 0.0136 0.0195
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0065 0.0136 0.0157
Brugia malayi RE15519p 0.0042 0.0025 0.0036
Echinococcus granulosus biogenic amine 5HT receptor 0.0042 0.0025 0.0025
Loa Loa (eye worm) G-protein coupled receptor 0.0042 0.0025 0.0036
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.0898 0.428 1
Brugia malayi ORL1-like opioid receptor 0.0042 0.0025 0.0036
Brugia malayi G-protein coupled receptor 0.0042 0.0025 0.0036
Loa Loa (eye worm) hypothetical protein 0.0069 0.0156 0.0224
Brugia malayi Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein 0.0376 0.1682 0.2419
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0042 0.0025 0.0036
Brugia malayi calpain family protein 1 0.0054 0.0082 0.0118
Schistosoma mansoni amine GPCR 0.0042 0.0025 0.0036
Entamoeba histolytica acetyltransferase, GNAT family 0.0041 0.0016 0.0038
Echinococcus multilocularis fmrfamide receptor 0.0042 0.0025 0.0025
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0042 0.0025 0.0025
Trypanosoma brucei lanosterol synthase 0.107 0.5133 1
Loa Loa (eye worm) hypothetical protein 0.0042 0.0025 0.0036
Loa Loa (eye worm) POT family protein 0.004 0.0015 0.0021
Loa Loa (eye worm) hypothetical protein 0.0042 0.0025 0.0036
Onchocerca volvulus 0.0394 0.1772 0.899
Chlamydia trachomatis ribonuclease Z 0.0051 0.007 0.5
Brugia malayi POT family protein 0.004 0.0015 0.0021
Loa Loa (eye worm) hypothetical protein 0.0042 0.0025 0.0036
Echinococcus multilocularis g protein coupled receptor 0.0042 0.0025 0.0025
Schistosoma mansoni hypothetical protein 0.0042 0.0025 0.0036
Schistosoma mansoni family M13 non-peptidase homologue (M13 family) 0.0047 0.0047 0.0068
Loa Loa (eye worm) hypothetical protein 0.0069 0.0156 0.0224
Schistosoma mansoni neprilysin-2 (M13 family) 0.0047 0.0047 0.0068
Loa Loa (eye worm) hypothetical protein 0.0042 0.0025 0.0036
Onchocerca volvulus 0.0433 0.1968 1
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.0056 0.0094 0.0094
Schistosoma mansoni lozenge 0.0054 0.0085 0.0122
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0204 0.0827 0.1189
Echinococcus granulosus rhodopsin orphan GPCR 0.0042 0.0025 0.0025
Schistosoma mansoni biogenic amine receptor 0.0042 0.0025 0.0036
Echinococcus granulosus GA binding protein alpha chain 0.0073 0.0177 0.0177
Plasmodium falciparum protein farnesyltransferase subunit alpha 0.0513 0.2362 0.5502
Echinococcus multilocularis transcription factor Dp 1 0.0037 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0042 0.0025 0.0036
Trypanosoma brucei geranylgeranyl transferase type II beta subunit, putative 0.0287 0.1243 0.242
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0042 0.0025 0.0025
Entamoeba histolytica protein farnesyltransferase alpha subunit, putative 0.0513 0.2362 0.552
Loa Loa (eye worm) angiotensin-converting enzyme family protein 0.0609 0.2843 0.4089
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0056 0.0094 0.0135
Loa Loa (eye worm) hypothetical protein 0.0042 0.0025 0.0036
Loa Loa (eye worm) hypothetical protein 0.0042 0.0025 0.0036
Loa Loa (eye worm) hypothetical protein 0.0174 0.0679 0.0977
Toxoplasma gondii Rab geranylgeranyl transferase type II beta subunit, putative 0.0287 0.1243 0.2847
Wolbachia endosymbiont of Brugia malayi metallo-beta-lactamase superfamily hydrolase 0.0051 0.007 0.5
Trypanosoma brucei metallo-beta-lactamase-like protein, putative 0.0051 0.007 0.0133
Leishmania major squalene synthase, putative 0.0735 0.347 0.8077
Echinococcus granulosus geranylgeranyl transferase type I beta subunit 0.0622 0.2907 0.2907
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.007 0.0163
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0044 0.0035 0.0081
Mycobacterium tuberculosis Possible hydrolase 0.0051 0.007 0.0133
Entamoeba histolytica metallo-beta-lactamase family protein 0.0051 0.007 0.0163
Schistosoma mansoni peptidyl-glycine monooxygenase 0.1436 0.6952 1
Brugia malayi Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein 0.0763 0.3605 0.5186
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0513 0.2362 0.552
Echinococcus granulosus g-protein coupled receptor 0.0042 0.0025 0.0025
Trypanosoma brucei hypothetical protein, conserved 0.0394 0.1772 0.345
Loa Loa (eye worm) hypothetical protein 0.0042 0.0025 0.0036
Echinococcus granulosus hypothetical protein 0.0042 0.0025 0.0025
Echinococcus granulosus tachykinin peptides receptor 99D 0.0042 0.0025 0.0025
Loa Loa (eye worm) hypothetical protein 0.0042 0.0025 0.0036
Loa Loa (eye worm) hypothetical protein 0.0038 0.0001 0.0002
Brugia malayi B-box type zinc-finger protein ncl-1 0.0038 0.0001 0.0002
Mycobacterium tuberculosis Conserved hypothetical protein 0.0051 0.007 0.0133
Brugia malayi G protein-coupled receptor 0.0042 0.0025 0.0036
Loa Loa (eye worm) neuropeptide F receptor 0.0042 0.0025 0.0036
Echinococcus multilocularis rhodopsin orphan GPCR 0.0042 0.0025 0.0025
Echinococcus multilocularis geranylgeranyl transferase type 2 subunit alpha 0.0394 0.1772 0.1772
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0042 0.0025 0.0025
Echinococcus multilocularis rhodopsin orphan GPCR 0.0042 0.0025 0.0025
Leishmania major protein farnesyltransferase alpha subunit, putative 0.0394 0.1772 0.4043
Entamoeba histolytica hypothetical protein, conserved 0.0051 0.007 0.0163
Echinococcus granulosus tm gpcr rhodopsin 0.0042 0.0025 0.0025
Echinococcus granulosus serotonin receptor 0.0042 0.0025 0.0025
Echinococcus multilocularis g protein coupled receptor 0.0042 0.0025 0.0025
Echinococcus granulosus rhodopsin orphan GPCR 0.0042 0.0025 0.0025
Loa Loa (eye worm) TYRA-2 protein 0.0042 0.0025 0.0036
Loa Loa (eye worm) hypothetical protein 0.0042 0.0025 0.0036
Mycobacterium tuberculosis Probable zinc metalloprotease Zmp1 0.0093 0.0276 0.0535
Schistosoma mansoni opsin-like receptor 0.0042 0.0025 0.0036
Echinococcus multilocularis protein farnesyltransferase alpha subunit 0.0513 0.2362 0.2362
Plasmodium vivax farnesyltransferase beta subunit, putative 0.0898 0.428 1
Brugia malayi hypothetical protein 0.0042 0.0025 0.0036
Schistosoma mansoni hypothetical protein 0.0042 0.0025 0.0036
Brugia malayi B-box zinc finger family protein 0.0038 0.0001 0.0002
Mycobacterium tuberculosis Beta lactamase like protein 0.0051 0.007 0.0133
Mycobacterium ulcerans zinc metalloprotease 0.0093 0.0276 0.2334
Schistosoma mansoni amine GPCR 0.0042 0.0025 0.0036
Schistosoma mansoni biogenic amine receptor 0.0042 0.0025 0.0036
Loa Loa (eye worm) hypothetical protein 0.0042 0.0025 0.0036
Brugia malayi Pre-SET motif family protein 0.0204 0.0827 0.1189
Loa Loa (eye worm) hypothetical protein 0.0042 0.0025 0.0036
Trypanosoma cruzi lanosterol synthase, putative 0.107 0.5133 1
Echinococcus multilocularis G protein coupled receptor 139 0.0042 0.0025 0.0025
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0042 0.0025 0.0036
Echinococcus granulosus 7tm_1 domain containing protein 0.0042 0.0025 0.0025
Loa Loa (eye worm) hypothetical protein 0.0042 0.0025 0.0036
Trichomonas vaginalis beta lactamase domain, putative 0.0051 0.007 0.0163
Loa Loa (eye worm) hypothetical protein 0.0046 0.0043 0.0062
Brugia malayi Dopamine receptor 0.0042 0.0025 0.0036
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0042 0.0025 0.0036
Loa Loa (eye worm) hypothetical protein 0.0042 0.0025 0.0036
Echinococcus multilocularis rhodopsin orphan GPCR 0.0042 0.0025 0.0025
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0065 0.0136 0.0136
Toxoplasma gondii peptidase family M13 protein 0.0093 0.0276 0.0568
Brugia malayi putative neuropeptide receptor NPR1 0.0042 0.0025 0.0036
Plasmodium vivax hydroxyacyl glutathione hydrolase, putative 0.0051 0.007 0.0082
Schistosoma mansoni peptidylglycine monooxygenase 0.0038 0.0001 0.0002
Brugia malayi Dopamine receptor protein 2 0.0042 0.0025 0.0036
Trypanosoma brucei squalene synthase, putative 0.0735 0.347 0.676
Loa Loa (eye worm) hypothetical protein 0.0042 0.0025 0.0036
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.0898 0.428 1
Trichomonas vaginalis beta lactamase domain, putative 0.0051 0.007 0.0163
Entamoeba histolytica metallo-beta-lactamase family protein 0.0051 0.007 0.0163
Echinococcus granulosus tm gpcr rhodopsin 0.0042 0.0025 0.0025
Loa Loa (eye worm) acetyltransferase 0.0151 0.0563 0.081
Schistosoma mansoni hypothetical protein 0.0038 0.0001 0.0002
Loa Loa (eye worm) hypothetical protein 0.0042 0.0025 0.0036
Onchocerca volvulus Putative hydrolase PNKD 0.0051 0.007 0.023
Loa Loa (eye worm) hypothetical protein 0.0287 0.1243 0.1788
Plasmodium falciparum protein farnesyltransferase subunit beta 0.0898 0.428 1
Trypanosoma brucei glyoxalase II 0.0051 0.007 0.0133
Echinococcus multilocularis zinc phosphodiesterase 0.0051 0.007 0.007
Brugia malayi ERG2 and Sigma1 receptor like protein 0.0174 0.0679 0.0977
Schistosoma mansoni hypothetical protein 0.0038 0.0001 0.0002
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0042 0.0025 0.0036
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0513 0.2362 0.552
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0042 0.0025 0.0036
Brugia malayi Protein prenyltransferase alpha subunit repeat containing protein 0.0394 0.1772 0.2549
Loa Loa (eye worm) hypothetical protein 0.0042 0.0025 0.0036
Mycobacterium leprae probable zinc metalloprotease 0.0093 0.0276 1
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.007 0.0163
Toxoplasma gondii metallo-beta-lactamase domain-containing protein 0.0051 0.007 0.0082
Brugia malayi Protein prenyltransferase alpha subunit repeat containing protein 0.0513 0.2362 0.3398
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0042 0.0025 0.0025
Trichomonas vaginalis beta lactamase domain, putative 0.0051 0.007 0.0163
Schistosoma mansoni hydroxyacylglutathione hydrolase (Glyoxalase II) (Glx II) 0.0051 0.007 0.01
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0042 0.0025 0.0036
Brugia malayi Peptidase family M13 containing protein 0.0093 0.0276 0.0397
Plasmodium vivax unspecified product 0.0051 0.007 0.0082
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0093 0.0276 0.0397
Brugia malayi Angiotensin-converting enzyme family protein 0.0609 0.2843 0.4089
Echinococcus granulosus biogenic amine 5HT receptor 0.0042 0.0025 0.0025
Brugia malayi Prenyltransferase and squalene oxidase repeat family protein 0.0622 0.2907 0.4182
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0042 0.0025 0.0036
Loa Loa (eye worm) hypothetical protein 0.0042 0.0025 0.0036
Brugia malayi acetyltransferase, GNAT family protein 0.0151 0.0563 0.081
Echinococcus granulosus dro:myosuppressin receptor 0.0042 0.0025 0.0025
Echinococcus multilocularis allatostatin A receptor 0.0042 0.0025 0.0025
Giardia lamblia Rab geranylgeranyltransferase 0.0394 0.1772 0.4138
Onchocerca volvulus 0.0046 0.0043 0.0095
Echinococcus granulosus g protein coupled receptor 0.0042 0.0025 0.0025
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.0044 0.0063
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.0044 0.0063
Loa Loa (eye worm) hypothetical protein 0.0051 0.007 0.01
Brugia malayi follicle stimulating hormone receptor 0.0042 0.0025 0.0036
Echinococcus multilocularis dro:myosuppressin receptor 0.0042 0.0025 0.0025
Brugia malayi larval opioid receptor 0.0042 0.0025 0.0036
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0042 0.0025 0.0025
Trichomonas vaginalis geranylgeranyl transferase type I beta subunit, putative 0.0622 0.2907 0.6793
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.007 0.0163
Brugia malayi B-box zinc finger family protein 0.0038 0.0001 0.0002
Schistosoma mansoni hypothetical protein 0.0051 0.007 0.01
Echinococcus granulosus 7TM GPCR rhodopsin 0.0042 0.0025 0.0025
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0042 0.0025 0.0025
Echinococcus granulosus Squalene phytoene synthase 0.0229 0.0954 0.0954
Schistosoma mansoni peptidylglycine monooxygenase 0.0763 0.3605 0.5186
Plasmodium vivax conserved Plasmodium protein, unknown function 0.0611 0.2851 0.6635
Toxoplasma gondii hypothetical protein 0.0394 0.1772 0.4092
Trichomonas vaginalis protein farnesyltransferase beta subunit, putative 0.0287 0.1243 0.2905
Trypanosoma cruzi squalene synthase, putative 0.0735 0.347 0.6716
Schistosoma mansoni hypothetical protein 0.0038 0.0001 0.0002
Trichomonas vaginalis beta lactamase domain, putative 0.0051 0.007 0.0163
Trypanosoma cruzi geranylgeranyl transferase type II beta subunit, putative 0.0287 0.1243 0.2318
Trypanosoma cruzi phytoene synthase, putative 0.0229 0.0954 0.1747
Toxoplasma gondii hydroxyacylglutathione hydrolase 0.0051 0.007 0.0082
Loa Loa (eye worm) hypothetical protein 0.0042 0.0025 0.0036
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0042 0.0025 0.0025
Loa Loa (eye worm) G-protein coupled receptor 0.0042 0.0025 0.0036
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.007 0.0163
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0042 0.0025 0.0036
Echinococcus multilocularis neuropeptide Y receptor 0.0042 0.0025 0.0025
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0042 0.0025 0.0025
Giardia lamblia Metallo-beta-lactamase superfamily protein 0.0051 0.007 0.016
Echinococcus granulosus sex peptide receptor 0.0042 0.0025 0.0025
Echinococcus multilocularis Protein lozenge 0.0054 0.0085 0.0085
Loa Loa (eye worm) hypothetical protein 0.0042 0.0025 0.0036
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0073 0.0177 0.0255
Echinococcus granulosus orexin receptor type 2 0.0042 0.0025 0.0025
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0056 0.0094 0.0135
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0042 0.0025 0.0036
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0044 0.0044
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0042 0.0025 0.0036
Echinococcus granulosus transcription factor Dp 1 0.0037 0.0001 0.0001
Giardia lamblia Hydroxyacylglutathione hydrolase 0.0051 0.007 0.016
Brugia malayi GnHR receptor homolog 0.0042 0.0025 0.0036
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0042 0.0025 0.0036
Entamoeba histolytica alkyl sulfatase, putative 0.0051 0.007 0.0163
Loa Loa (eye worm) hypothetical protein 0.0042 0.0025 0.0036
Echinococcus granulosus neuropeptide Y receptor 0.0042 0.0025 0.0025
Brugia malayi Ets-domain containing protein 0.0073 0.0177 0.0255
Brugia malayi Ets-domain containing protein 0.0073 0.0177 0.0255
Schistosoma mansoni amine GPCR 0.0042 0.0025 0.0036
Leishmania major lanosterol synthase, putative 0.0783 0.3704 0.8633
Brugia malayi Dopamine receptor protein 1 0.0042 0.0025 0.0036
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0065 0.0136 0.0195
Loa Loa (eye worm) hypothetical protein 0.0042 0.0025 0.0036
Brugia malayi B-box type zinc-finger protein ncl-1 0.0038 0.0001 0.0002
Echinococcus multilocularis Rab geranylgeranyltransferase, beta subunit 0.0287 0.1243 0.1243
Brugia malayi Chain A, Human Glyoxalase Ii With Cacodylate And Acetate Ions Present In The Active Site. 0.0051 0.007 0.01
Brugia malayi neuropeptide F receptor 0.0042 0.0025 0.0036
Echinococcus granulosus calpain A 0.0056 0.0094 0.0094
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0042 0.0025 0.0025
Loa Loa (eye worm) hypothetical protein 0.0229 0.0954 0.1373
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0042 0.0025 0.0036
Loa Loa (eye worm) hypothetical protein 0.0042 0.0025 0.0036
Brugia malayi Copper type II ascorbate-dependent monooxygenase, N-terminal domain containing protein 0.0387 0.1738 0.2501
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0054 0.0082 0.0118
Echinococcus granulosus protein farnesyltransferase subunit beta 0.0898 0.428 0.428
Loa Loa (eye worm) hypothetical protein 0.007 0.0164 0.0235
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0047 0.0047 0.0068
Loa Loa (eye worm) B-box zinc finger family protein 0.0038 0.0001 0.0002
Brugia malayi Hypothetical zinc metalloproteinase T16A9.4 0.0093 0.0276 0.0397
Schistosoma mansoni biogenic amine (5HT) receptor 0.0042 0.0025 0.0036
Echinococcus multilocularis neuropeptide receptor A26 0.0042 0.0025 0.0025
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0042 0.0025 0.0036
Brugia malayi G protein-coupled receptor F59B2.13 0.0042 0.0025 0.0036
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0042 0.0025 0.0036
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0042 0.0025 0.0036
Brugia malayi Probable protein farnesyltransferase beta subunit, putative 0.0287 0.1243 0.1788
Schistosoma mansoni histamine h1 receptor 0.0042 0.0025 0.0036
Echinococcus multilocularis protein farnesyltransferase subunit beta 0.0898 0.428 0.428
Echinococcus granulosus neuropeptide FF receptor 2 0.0042 0.0025 0.0025
Trichomonas vaginalis apoptosis inducing factor, putative 0.0051 0.007 0.0163
Mycobacterium tuberculosis Conserved protein 0.0051 0.007 0.0133
Giardia lamblia Rab geranylgeranyltransferase 0.0287 0.1243 0.2903
Loa Loa (eye worm) hypothetical protein 0.0042 0.0025 0.0036
Toxoplasma gondii hypothetical protein 0.0119 0.0405 0.0873
Echinococcus multilocularis orexin receptor type 2 0.0042 0.0025 0.0025
Trichomonas vaginalis beta lactamase domain, putative 0.0051 0.007 0.0163
Echinococcus multilocularis rhodopsin orphan GPCR 0.0042 0.0025 0.0025
Echinococcus granulosus protein prenyltransferase alpha subunit 0.0394 0.1772 0.1772
Echinococcus granulosus neuropeptide receptor 0.0042 0.0025 0.0025
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0042 0.0025 0.0025
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0136 0.0131
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0042 0.0025 0.0025
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.2049 1 1
Echinococcus granulosus brain tumor protein 0.0038 0.0001 0.0001
Echinococcus multilocularis tripartite motif containing protein 3 0.0038 0.0001 0.0001
Echinococcus multilocularis g protein coupled receptor 0.0042 0.0025 0.0025
Schistosoma mansoni geranylgeranyl transferase type I beta subunit 0.0622 0.2907 0.4182
Schistosoma mansoni zinc phosphodiesterase 0.0051 0.007 0.01
Echinococcus multilocularis calpain family protein 1, d 0.004 0.0011 0.0011
Mycobacterium tuberculosis Halimadienyl diphosphate synthase 0.107 0.5133 1
Echinococcus granulosus metallo beta lactamase domain containing protein 0.0051 0.007 0.007
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0042 0.0025 0.0036
Loa Loa (eye worm) prenyltransferase and squalene oxidase repeat family protein 0.0898 0.428 0.6156
Brugia malayi hypothetical protein 0.0042 0.0025 0.0036
Entamoeba histolytica type A flavoprotein, putative 0.0051 0.007 0.0163
Entamoeba histolytica hypothetical protein 0.0038 0.0001 0.0003
Echinococcus granulosus neuropeptide Y receptor 0.0042 0.0025 0.0025
Schistosoma mansoni ets-related 0.0221 0.0914 0.1315
Schistosoma mansoni neuropeptide receptor 0.0042 0.0025 0.0036
Echinococcus multilocularis calpain A 0.0056 0.0094 0.0094
Mycobacterium tuberculosis Conserved protein 0.0051 0.007 0.0133
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0051 0.007 0.0163
Loa Loa (eye worm) hypothetical protein 0.0433 0.1968 0.2831
Echinococcus granulosus expressed protein 0.0726 0.3422 0.3422
Schistosoma mansoni protein farnesyltransferase alpha subunit 0.0513 0.2362 0.3398
Onchocerca volvulus 0.0051 0.007 0.023
Trichomonas vaginalis beta lactamase domain, putative 0.0051 0.007 0.0163
Echinococcus multilocularis endothelin converting enzyme 1 0.0093 0.0276 0.0276
Schistosoma mansoni amine GPCR 0.0042 0.0025 0.0036
Echinococcus multilocularis serotonin receptor 0.0042 0.0025 0.0025
Echinococcus granulosus rhodopsin orphan GPCR 0.0042 0.0025 0.0025
Loa Loa (eye worm) hypothetical protein 0.007 0.0164 0.0235
Entamoeba histolytica type A flavoprotein, putative 0.0051 0.007 0.0163
Plasmodium falciparum geranylgeranyltransferase, putative 0.0287 0.1243 0.2878
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0042 0.0025 0.0036
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0065 0.0136 0.0195
Onchocerca volvulus 0.0051 0.007 0.023
Echinococcus multilocularis expressed protein 0.0726 0.3422 0.3422
Mycobacterium tuberculosis Possible hydrolase 0.0051 0.007 0.0133
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0044 0.0044
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0136 0.0262
Loa Loa (eye worm) hypothetical protein 0.0042 0.0025 0.0036
Schistosoma mansoni Nep2 peptidase (M13 family) 0.0047 0.0047 0.0068
Mycobacterium ulcerans phytoene synthase, CrtB 0.0229 0.0954 1
Loa Loa (eye worm) NCL-1 protein 0.0038 0.0001 0.0002
Loa Loa (eye worm) hypothetical protein 0.0042 0.0025 0.0036
Trypanosoma cruzi squalene synthase, putative 0.0735 0.347 0.6716
Plasmodium vivax geranylgeranyltransferase, putative 0.0287 0.1243 0.2847
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0042 0.0025 0.0025
Leishmania major C-8 sterol isomerase-like protein 0.0174 0.0679 0.1448
Trypanosoma brucei Protein prenyltransferase alpha subunit repeat, putative 0.0394 0.1772 0.345
Echinococcus multilocularis protein prenyltransferase alpha subunit 0.0394 0.1772 0.1772
Trypanosoma cruzi lanosterol synthase, putative 0.107 0.5133 1
Trichomonas vaginalis geranylgeranyl transferase type I beta subunit, putative 0.0898 0.428 1
Echinococcus granulosus g protein coupled receptor 0.0042 0.0025 0.0025
Loa Loa (eye worm) hypothetical protein 0.007 0.0164 0.0235
Trypanosoma cruzi hypothetical protein, conserved 0.0394 0.1772 0.3362
Brugia malayi hypothetical protein 0.0042 0.0025 0.0036
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0042 0.0025 0.0036
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0044 0.0063
Schistosoma mansoni amine GPCR 0.0042 0.0025 0.0036
Echinococcus multilocularis fmrfamide receptor 0.0042 0.0025 0.0025
Echinococcus granulosus metallo beta lactamase domain containing protein 0.0051 0.007 0.007
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0065 0.0136 0.0317
Loa Loa (eye worm) hypothetical protein 0.0051 0.007 0.01
Trichomonas vaginalis geranylgeranyl transferase type beta subunit, putative 0.0898 0.428 1
Loa Loa (eye worm) hypothetical protein 0.0051 0.007 0.01
Mycobacterium tuberculosis Conserved protein 0.0051 0.007 0.0133
Trypanosoma cruzi protein farnesyltransferase alpha subunit, putative 0.0394 0.1772 0.3362
Schistosoma mansoni opsin-like receptor 0.0042 0.0025 0.0036
Echinococcus granulosus neuropeptide receptor 0.0042 0.0025 0.0025
Echinococcus multilocularis geranylgeranyl transferase type I beta subunit 0.0622 0.2907 0.2907
Brugia malayi hypothetical protein 0.0042 0.0025 0.0036
Echinococcus multilocularis peptidyl glycine alpha amidating monooxygenase 0.1436 0.6952 0.6952
Onchocerca volvulus NADH dehydrogenase (ubiquinone) complex I, assembly factor 6 homolog 0.0229 0.0954 0.4782
Loa Loa (eye worm) B-box zinc finger family protein 0.0038 0.0001 0.0002
Loa Loa (eye worm) hypothetical protein 0.0287 0.1243 0.1788
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0044 0.0063
Brugia malayi neuropeptide F receptor 0.0042 0.0025 0.0036
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0042 0.0025 0.0036
Echinococcus multilocularis neuropeptide s receptor 0.0042 0.0025 0.0025
Trypanosoma cruzi protein farnesyltransferase, putative 0.0898 0.428 0.8315
Entamoeba histolytica Rab geranylgeranyltransferase beta subunit, putative 0.0287 0.1243 0.2905
Schistosoma mansoni hypothetical protein 0.0051 0.007 0.01
Echinococcus granulosus neuropeptides capa receptor 0.0042 0.0025 0.0025
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0042 0.0025 0.0036
Leishmania major farnesyltransferase beta subunit 0.0898 0.428 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0042 0.0025 0.0025
Schistosoma mansoni geranylgeranyl transferase type I beta subunit 0.0622 0.2907 0.4182
Brugia malayi ethe1-prov protein 0.0051 0.007 0.01
Echinococcus multilocularis neuropeptide Y receptor 0.0042 0.0025 0.0025
Echinococcus multilocularis somatostatin receptor 0.0042 0.0025 0.0025
Loa Loa (eye worm) neuropeptide F receptor 0.0042 0.0025 0.0036
Loa Loa (eye worm) hypothetical protein 0.0042 0.0025 0.0036
Plasmodium falciparum cytosolic glyoxalase II 0.0051 0.007 0.0125
Echinococcus granulosus ETHE1 protein 0.0051 0.007 0.007
Echinococcus multilocularis sex peptide receptor 0.0042 0.0025 0.0025
Loa Loa (eye worm) hypothetical protein 0.0042 0.0025 0.0036
Schistosoma mansoni hypothetical protein 0.0038 0.0001 0.0002
Schistosoma mansoni neuropeptide f receptor 76f 0.0042 0.0025 0.0036
Loa Loa (eye worm) hypothetical protein 0.004 0.0011 0.0016
Echinococcus granulosus tripartite motif containing protein 3 0.0038 0.0001 0.0001
Entamoeba histolytica metallo-beta-lactamase superfamily protein 0.0051 0.007 0.0163
Loa Loa (eye worm) hypothetical protein 0.0042 0.0025 0.0036
Mycobacterium tuberculosis Conserved hypothetical protein 0.0051 0.007 0.0133
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0042 0.0025 0.0036
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0047 0.0047 0.0068
Brugia malayi hypothetical protein 0.0042 0.0025 0.0036
Echinococcus multilocularis neuropeptide receptor 0.0042 0.0025 0.0025
Schistosoma mansoni hypothetical protein 0.0042 0.0025 0.0036
Echinococcus granulosus protein farnesyltransferase alpha subunit 0.0513 0.2362 0.2362
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0042 0.0025 0.0025
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0394 0.1772 0.414
Trypanosoma brucei protein farnesyltransferase alpha subunit, putative 0.0394 0.1772 0.345
Schistosoma mansoni geranylgeranyl transferase type II beta subunit 0.0287 0.1243 0.1788
Mycobacterium tuberculosis Probable phytoene synthase PhyA 0.0229 0.0954 0.1857
Loa Loa (eye worm) hypothetical protein 0.0042 0.0025 0.0036
Entamoeba histolytica metallo-beta-lactamase superfamily protein 0.0051 0.007 0.0163
Loa Loa (eye worm) hypothetical protein 0.0042 0.0025 0.0036
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0042 0.0025 0.0036
Loa Loa (eye worm) hypothetical protein 0.0763 0.3605 0.5186
Schistosoma mansoni microtubule-associated protein tau 0.0675 0.317 0.4559
Loa Loa (eye worm) RING finger protein nhl-1 0.0038 0.0001 0.0002
Brugia malayi AKH receptor 0.0042 0.0025 0.0036
Echinococcus multilocularis rhodopsin orphan GPCR 0.0042 0.0025 0.0025
Schistosoma mansoni dopamine-beta-monooxygenase 0.0763 0.3605 0.5186
Echinococcus granulosus G protein coupled receptor 139 0.0042 0.0025 0.0025
Loa Loa (eye worm) hypothetical protein 0.0042 0.0025 0.0036
Echinococcus granulosus neuropeptides capa receptor 0.0042 0.0025 0.0025
Loa Loa (eye worm) hypothetical protein 0.0513 0.2362 0.3398
Echinococcus multilocularis rhodopsin orphan GPCR 0.0042 0.0025 0.0025
Trypanosoma cruzi hypothetical protein, conserved 0.0287 0.1243 0.2318
Loa Loa (eye worm) hypothetical protein 0.0042 0.0025 0.0036
Leishmania major hypothetical protein, conserved 0.0229 0.0954 0.2101
Schistosoma mansoni hypothetical protein 0.0042 0.0025 0.0036
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.007 0.0163
Loa Loa (eye worm) hypothetical protein 0.1436 0.6952 1
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0042 0.0025 0.0025
Echinococcus granulosus peptidyl glycine alpha amidating monooxygenase 0.1436 0.6952 0.6952
Loa Loa (eye worm) hypothetical protein 0.0038 0.0001 0.0002
Brugia malayi hypothetical protein 0.0042 0.0025 0.0036
Echinococcus multilocularis neuropeptides capa receptor 0.0042 0.0025 0.0025
Schistosoma mansoni neuropeptide receptor 0.0042 0.0025 0.0036
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0042 0.0025 0.0036
Loa Loa (eye worm) hypothetical protein 0.0042 0.0025 0.0036
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0044 0.0063
Leishmania major geranylgeranyltransferase, putative 0.0287 0.1243 0.2788
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0042 0.0025 0.0025
Loa Loa (eye worm) prenyltransferase alpha subunit repeat containing protein 0.0513 0.2362 0.3398
Brugia malayi G-protein coupled receptor 0.0042 0.0025 0.0036
Loa Loa (eye worm) melatonin receptor type 1A 0.0042 0.0025 0.0036
Brugia malayi Prenyltransferase and squalene oxidase repeat family protein 0.0898 0.428 0.6156
Loa Loa (eye worm) peptidase family M13 containing protein 0.0069 0.0156 0.0224
Giardia lamblia Rab geranylgeranyltransferase 0.0513 0.2362 0.5518
Schistosoma mansoni opsin-like receptor 0.0042 0.0025 0.0036
Plasmodium falciparum geranylgeranyl transferase type2 beta subunit, putative 0.0287 0.1243 0.2878
Trypanosoma brucei hydroxyacylglutathione hydrolase, putative 0.0051 0.007 0.0133
Schistosoma mansoni protein farnesyltransferase subunit beta 0.0898 0.428 0.6156
Loa Loa (eye worm) hypothetical protein 0.0048 0.0051 0.0074
Schistosoma mansoni hypothetical protein 0.0051 0.007 0.01
Loa Loa (eye worm) hypothetical protein 0.0433 0.1968 0.2831
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.0898 0.428 1
Schistosoma mansoni adenoreceptor 0.0042 0.0025 0.0036
Echinococcus granulosus endothelin converting enzyme 1 0.0093 0.0276 0.0276
Loa Loa (eye worm) hypothetical protein 0.0042 0.0025 0.0036
Echinococcus multilocularis neuropeptide receptor 0.0042 0.0025 0.0025
Giardia lamblia Prenyltransferase 0.0898 0.428 1
Echinococcus granulosus zinc phosphodiesterase 0.0051 0.007 0.007
Loa Loa (eye worm) hypothetical protein 0.0042 0.0025 0.0036
Loa Loa (eye worm) hypothetical protein 0.0042 0.0025 0.0036
Schistosoma mansoni biogenic amine receptor 0.0042 0.0025 0.0036
Trichomonas vaginalis protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative 0.0119 0.0405 0.0947
Echinococcus multilocularis hydroxyacylglutathione hydrolase 0.0051 0.007 0.007
Loa Loa (eye worm) hypothetical protein 0.0042 0.0025 0.0036
Echinococcus granulosus fmrfamide receptor 0.0042 0.0025 0.0025
Loa Loa (eye worm) runx1 0.0054 0.0085 0.0122
Echinococcus multilocularis GA binding protein alpha chain 0.0073 0.0177 0.0177
Echinococcus multilocularis neuropeptide FF receptor 2 0.0042 0.0025 0.0025
Onchocerca volvulus Hydroxyacylglutathione hydrolase, mitochondrial homolog 0.0051 0.007 0.023
Echinococcus multilocularis neuropeptides capa receptor 0.0042 0.0025 0.0025
Echinococcus granulosus peptide allatostatin:somatostatin 0.0042 0.0025 0.0025
Trypanosoma cruzi protein farnesyltransferase alpha subunit, putative 0.0394 0.1772 0.3362
Entamoeba histolytica geranylgeranyl transferase beta subunit 0.0622 0.2907 0.6793
Echinococcus multilocularis g-protein coupled receptor 0.0042 0.0025 0.0025
Brugia malayi metallo-beta-lactamase superfamily protein 0.0051 0.007 0.01
Loa Loa (eye worm) hypothetical protein 0.0038 0.0001 0.0002
Trypanosoma brucei protein farnesyltransferase beta subunit 0.0898 0.428 0.8338
Echinococcus granulosus neuropeptide s receptor 0.0042 0.0025 0.0025
Echinococcus granulosus alpha 1A adrenergic receptor 0.0042 0.0025 0.0025
Schistosoma mansoni brat protein 0.0038 0.0001 0.0002
Echinococcus granulosus microtubule associated protein 2 0.0675 0.317 0.317
Plasmodium falciparum geranylgeranyl transferase type-2 subunit alpha, putative 0.0394 0.1772 0.4117
Onchocerca volvulus 0.0232 0.0966 0.4845
Brugia malayi hypothetical protein 0.0042 0.0025 0.0036
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0042 0.0025 0.0025
Brugia malayi calpain family protein 1 0.0054 0.0082 0.0118
Echinococcus multilocularis metallo beta lactamase domain containing protein 0.0051 0.007 0.007
Trichomonas vaginalis set domain proteins, putative 0.0232 0.0966 0.2258
Echinococcus granulosus histone acetyltransferase KAT2B 0.0044 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.0093 0.0276 0.0397
Trypanosoma brucei Protein prenyltransferase alpha subunit repeat, putative 0.0394 0.1772 0.345
Loa Loa (eye worm) hypothetical protein 0.0069 0.0156 0.0224
Schistosoma mansoni biogenic amine (5HT) receptor 0.0042 0.0025 0.0036
Trypanosoma brucei cleavage and polyadenylation specificity factor subunit, putative 0.0051 0.007 0.0133
Trypanosoma cruzi protein farnesyltransferase, putative 0.0898 0.428 0.8315
Loa Loa (eye worm) hypothetical protein 0.0042 0.0025 0.0036
Brugia malayi Tachykinin-like peptides receptor 99D 0.0042 0.0025 0.0036
Trypanosoma cruzi hypothetical protein, conserved 0.0394 0.1772 0.3362
Loa Loa (eye worm) prenyltransferase alpha subunit repeat containing protein 0.0394 0.1772 0.2549
Trichomonas vaginalis bromodomain-containing protein, putative 0.0044 0.0035 0.0081
Trichomonas vaginalis type I geranylgeranyltransferase beta subunit, putative 0.0898 0.428 1
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0394 0.1772 0.2549
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0042 0.0025 0.0036
Trypanosoma cruzi hypothetical protein, conserved 0.0287 0.1243 0.2318
Loa Loa (eye worm) hypothetical protein 0.0042 0.0025 0.0036
Brugia malayi Serotonin receptor 0.0042 0.0025 0.0036
Schistosoma mansoni hypothetical protein 0.0229 0.0954 0.1373
Plasmodium vivax protein prenyltransferase alpha subunit, putative 0.0394 0.1772 0.4092
Loa Loa (eye worm) hypothetical protein 0.007 0.0164 0.0235
Schistosoma mansoni zinc phosphodiesterase 0.0051 0.007 0.01
Trichomonas vaginalis protein farnesyltransferase beta subunit, putative 0.0287 0.1243 0.2905
Loa Loa (eye worm) hypothetical protein 0.0093 0.0276 0.0397
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0136 0.0131
Echinococcus multilocularis brain tumor protein 0.0038 0.0001 0.0001
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0065 0.0136 0.0136
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0044 0.0044
Loa Loa (eye worm) hypothetical protein 0.0051 0.007 0.01
Loa Loa (eye worm) hydroxyacylglutathione hydrolase 0.0051 0.007 0.01
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0042 0.0025 0.0036
Loa Loa (eye worm) calpain family protein 1 0.004 0.0011 0.0016
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0042 0.0025 0.0036
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0151 0.0563 0.081
Entamoeba histolytica protein farnesyltransferase beta subunit, putative 0.0898 0.428 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0042 0.0025 0.0025
Loa Loa (eye worm) hydroxyacylglutathione hydrolase cytoplasmic 0.0051 0.007 0.01
Brugia malayi hypothetical protein 0.0042 0.0025 0.0036
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0042 0.0025 0.0036
Brugia malayi Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein 0.1436 0.6952 1
Trypanosoma cruzi Protein prenyltransferase alpha subunit repeat, putative 0.0394 0.1772 0.3362
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0042 0.0025 0.0036
Brugia malayi metallo-beta-lactamase superfamily protein 0.0051 0.007 0.01
Echinococcus granulosus allatostatin A receptor 0.0042 0.0025 0.0025
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0042 0.0025 0.0025
Loa Loa (eye worm) hypothetical protein 0.0093 0.0276 0.0397
Brugia malayi sulfakinin receptor protein 0.0042 0.0025 0.0036
Loa Loa (eye worm) hypothetical protein 0.0042 0.0025 0.0036
Echinococcus multilocularis G-protein coupled receptor, putative 0.0042 0.0025 0.0025
Echinococcus multilocularis rhodopsin orphan GPCR 0.0042 0.0025 0.0025
Schistosoma mansoni alpha-1 adrenergic receptor 0.0042 0.0025 0.0036
Loa Loa (eye worm) hypothetical protein 0.007 0.0164 0.0235
Echinococcus multilocularis rhodopsin orphan GPCR 0.0042 0.0025 0.0025
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0042 0.0025 0.0036
Schistosoma mansoni neuropeptide F-like receptor 0.0042 0.0025 0.0036
Loa Loa (eye worm) hypothetical protein 0.007 0.0164 0.0235
Schistosoma mansoni neuropeptide receptor 0.0042 0.0025 0.0036
Echinococcus multilocularis brain tumor protein 0.0038 0.0001 0.0001
Trichomonas vaginalis protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative 0.0513 0.2362 0.552
Echinococcus granulosus histone acetyltransferase KAT2B 0.0146 0.0542 0.0542
Plasmodium vivax prenyltransferase alpha subunit, putative 0.0513 0.2362 0.5483

Activities

Activity type Activity value Assay description Source Reference
Adjusted Ki (binding) = 0.83 nM Inhibitory activity against scytalone dehydratase enzyme obtained from Magnaporthe grisea ChEMBL. 10386945
Adjusted Ki (binding) = 0.83 nM Inhibitory activity against scytalone dehydratase enzyme obtained from Magnaporthe grisea ChEMBL. 10386945
ED90 (functional) = 100 mg l-1 Concentration that affords 90% control of blast disease on rice plants by multiple rate foliar rice blast assay ChEMBL. 10386945
Ki (binding) = 1.7 nM Inhibitory activity against scytalone dehydratase enzyme obtained from Magnaporthe grisea ChEMBL. 10386945
Ki (binding) = 1.7 nM Inhibitory activity against scytalone dehydratase enzyme obtained from Magnaporthe grisea ChEMBL. 10386945

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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