Detailed information for compound 624095

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 431.48 | Formula: C26H25NO5
  • H donors: 1 H acceptors: 3 LogP: 4.81 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCOc1ccc(cc1)C1C(=C(C(=O)N1Cc1ccco1)O)C(=O)c1ccc(cc1)C
  • InChi: 1S/C26H25NO5/c1-3-14-31-20-12-10-18(11-13-20)23-22(24(28)19-8-6-17(2)7-9-19)25(29)26(30)27(23)16-21-5-4-15-32-21/h4-13,15,23,29H,3,14,16H2,1-2H3
  • InChiKey: QMJRWRUJGMKUMR-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.004 0.0168 0.0455
Brugia malayi hypothetical protein 0.0106 0.0562 0.1545
Echinococcus multilocularis polycomb protein SCMH1 0.0035 0.0139 0.0275
Brugia malayi SET domain containing protein 0.0016 0.0023 0.0057
Echinococcus multilocularis multidrug resistance protein 1 0.0012 0.0003 0.0005
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0.0039 0.0037
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0297 0.0585
Loa Loa (eye worm) beta-lactamase 0.0106 0.0561 0.1544
Loa Loa (eye worm) hypothetical protein 0.0028 0.0095 0.0257
Plasmodium falciparum JmjC domain-containing protein, putative 0.0026 0.0083 0.0282
Onchocerca volvulus 0.0018 0.0038 0.0091
Loa Loa (eye worm) hypothetical protein 0.0242 0.1372 0.3785
Trichomonas vaginalis chromobox protein, putative 0.0071 0.0355 0.0854
Echinococcus multilocularis multidrug resistance protein 1 0.0012 0.0003 0.0005
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0039 0.0655
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0022 0.0047
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0677 0.3957 0.3956
Schistosoma mansoni cpg binding protein 0.0031 0.0114 0.022
Trypanosoma brucei trans-sialidase, putative 0.0024 0.0072 0.0291
Trypanosoma cruzi trans-sialidase, Group I, putative 0.0024 0.0072 0.0631
Schistosoma mansoni hypothetical protein 0.0049 0.0224 0.0441
Schistosoma mansoni phosphatidylserine receptor 0.0026 0.0083 0.016
Echinococcus granulosus chromobox protein 1 0.0071 0.0355 0.0705
Onchocerca volvulus 0.0106 0.0561 0.1357
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0146 0.0801 0.0764
Loa Loa (eye worm) jmjC domain-containing protein 0.0026 0.0083 0.0225
Loa Loa (eye worm) hypothetical protein 0.0027 0.0092 0.0248
Trypanosoma cruzi trans-sialidase, Group I, putative 0.0024 0.0072 0.0631
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0299 0.1712 0.414
Trypanosoma cruzi Macro domain containing protein, putative 0.0054 0.0254 0.4118
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0047 0.0212 0.042
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0035 0.0139 0.0336
Brugia malayi Calcitonin receptor-like protein seb-1 0.0149 0.0819 0.2255
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0013 0.001 0.0021
Brugia malayi Heterochromatin protein 1 0.0071 0.0355 0.0974
Mycobacterium ulcerans esterase/lipase LipP 0.0106 0.0561 0.0524
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0018 0.0039 0.001
Echinococcus granulosus 5'partial|ATP binding cassette sub family B 0.0012 0.0002 0.0004
Mycobacterium tuberculosis Conserved protein 0.0106 0.0561 0.0558
Brugia malayi F/Y-rich N-terminus family protein 0.0022 0.0064 0.0169
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0042 0.0094
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0108 0.0594
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.009 0.0463 0.0915
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0297 0.0585
Loa Loa (eye worm) jmjC domain-containing protein 0.0062 0.0297 0.0816
Echinococcus granulosus jumonji domain containing protein 0.0042 0.0178 0.0353
Entamoeba histolytica hypothetical protein 0.0106 0.0562 0.327
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.0031 0.0118 0.0279
Mycobacterium tuberculosis Probable lipase LipE 0.0106 0.0561 0.0558
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0039 0.0078
Echinococcus granulosus H2A histone family member Y 0.0018 0.0038 0.0075
Toxoplasma gondii ABC1 family protein 0.0106 0.0561 0.3145
Brugia malayi CHD4 protein 0.0013 0.001 0.0021
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0039 0.0128
Onchocerca volvulus 0.0028 0.0095 0.023
Schistosoma mansoni intermediate filament proteins 0.0028 0.0095 0.0183
Loa Loa (eye worm) hypothetical protein 0.0102 0.0538 0.148
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0013 0.001 0.0015
Entamoeba histolytica hypothetical protein 0.0106 0.0562 0.327
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0068 0.0333 0.1931
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.009 0.0463 0.0915
Trypanosoma cruzi ubiquitin-conjugating enzyme E2, putative 0.0031 0.0118 0.1506
Schistosoma mansoni sex comb on midleg homolog 0.0035 0.0139 0.027
Echinococcus multilocularis lamin 0.0028 0.0095 0.0188
Loa Loa (eye worm) hypothetical protein 0.004 0.0168 0.0457
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0019 0.0044
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0068 0.0333 0.0912
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0141 0.077 0.153
Plasmodium vivax hypothetical protein, conserved 0.0018 0.0038 0.0624
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0142 0.0773 0.1535
Trypanosoma cruzi ubiquitin-conjugating enzyme E2, putative 0.0031 0.0118 0.1506
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0068 0.0333 0.0656
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0042 0.0094
Brugia malayi hypothetical protein 0.0242 0.1372 0.3783
Schistosoma mansoni jumonji/arid domain-containing protein 0.0098 0.0515 0.1017
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0012 0.0003 0.0005
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0158 0.0871 0.1729
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.004 0.0168 0.0333
Brugia malayi Ubiquitin conjugating enzyme protein 13 0.0031 0.0118 0.0318
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0106 0.0561 0.0524
Echinococcus multilocularis beta LACTamase domain containing family member 0.0106 0.0561 0.1113
Loa Loa (eye worm) glutaminase 0.0201 0.1124 0.3099
Brugia malayi Pre-SET motif family protein 0.062 0.3622 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0047 0.0212 0.042
Entamoeba histolytica ubiquitin-conjugating enzyme family protein 0.0031 0.0118 0.0673
Echinococcus multilocularis ATP binding cassette sub family B 0.0012 0.0002 0.0004
Wolbachia endosymbiont of Brugia malayi N-acetylglucosamine-1-phosphate uridyltransferase 0.1692 1 1
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.001 0.002
Loa Loa (eye worm) hypothetical protein 0.0106 0.0561 0.1544
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0013 0.001 0.0021
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0095 0.0257
Loa Loa (eye worm) hypothetical protein 0.0047 0.0212 0.0579
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0049 0.0224 0.0613
Treponema pallidum licC protein (licC) 0.031 0.1777 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.009 0.0463 0.0915
Onchocerca volvulus 0.0706 0.4131 1
Schistosoma mansoni chromobox protein 0.0071 0.0355 0.07
Schistosoma mansoni hypothetical protein 0.0047 0.0212 0.0415
Trichomonas vaginalis D-aminoacylase, putative 0.0106 0.0561 0.1352
Loa Loa (eye worm) ubiquitin conjugating enzyme protein 13 0.0031 0.0118 0.032
Echinococcus multilocularis chromobox protein 1 0.0071 0.0355 0.0705
Entamoeba histolytica hypothetical protein, conserved 0.0054 0.0254 0.147
Brugia malayi Appr-1-p processing enzyme family protein 0.0054 0.0254 0.0694
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0141 0.077 0.1525
Mycobacterium ulcerans beta-lactamase 0.0106 0.0561 0.0524
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0068 0.0333 0.0914
Mycobacterium tuberculosis Conserved hypothetical protein 0.031 0.1777 0.1775
Trypanosoma brucei hypothetical protein, conserved 0.0106 0.0561 0.4607
Echinococcus granulosus beta LACTamase domain containing family member 0.0106 0.0561 0.1113
Loa Loa (eye worm) CHromoDomain protein family member 0.0013 0.001 0.0023
Trypanosoma cruzi trans-sialidase, Group I, putative 0.0024 0.0072 0.0631
Trypanosoma cruzi trans-sialidase, putative 0.0024 0.0072 0.0631
Loa Loa (eye worm) mbt repeat family protein 0.0035 0.0139 0.0378
Brugia malayi mbt repeat family protein 0.0035 0.0139 0.0376
Echinococcus granulosus survival motor neuron protein 1 0.0242 0.1372 0.2724
Trypanosoma cruzi hypothetical protein, conserved 0.0106 0.0561 1
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0026 0.0083 0.0847
Entamoeba histolytica hypothetical protein 0.0106 0.0562 0.327
Schistosoma mansoni hypothetical protein 0.0047 0.0212 0.0415
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.009 0.0463 0.092
Loa Loa (eye worm) hypothetical protein 0.0149 0.0819 0.2256
Plasmodium falciparum ubiquitin-conjugating enzyme E2 N, putative 0.0031 0.0118 0.0403
Loa Loa (eye worm) hypothetical protein 0.0026 0.0083 0.0225
Echinococcus multilocularis survival motor neuron protein 1 0.0242 0.1372 0.2724
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0169 0.0402
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.062 0.3622 1
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0142 0.0773 0.1535
Schistosoma mansoni protein phosphatase 2C 0.0026 0.0083 0.016
Echinococcus multilocularis peregrin 0.003 0.0108 0.0215
Brugia malayi ubiquitin conjugating enzyme protein 13 0.0031 0.0118 0.0318
Loa Loa (eye worm) hypothetical protein 0.003 0.0108 0.0294
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.003 0.0108 0.021
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0146 0.0801 0.0798
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0068 0.0333 0.5916
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0039 0.0078
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0039 0.0101
Echinococcus granulosus cpg binding protein 0.0033 0.0124 0.0247
Echinococcus granulosus intermediate filament protein 0.0028 0.0095 0.0188
Echinococcus multilocularis JmjC domain containing protein 4 0.0026 0.0083 0.0166
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0299 0.1712 0.414
Echinococcus granulosus jumonji domain containing 1A 0.0026 0.0083 0.0166
Onchocerca volvulus 0.0035 0.0139 0.0336
Trichomonas vaginalis set domain proteins, putative 0.0706 0.4131 1
Trichomonas vaginalis ganglioside induced differentiation associated protein, putative 0.0018 0.0038 0.0084
Schistosoma mansoni hypothetical protein 0.0054 0.0254 0.0499
Echinococcus multilocularis lysine specific demethylase 6a 0.0026 0.0083 0.0166
Echinococcus multilocularis MACRO domain containing protein 2 0.0054 0.0254 0.0504
Echinococcus granulosus geminin 0.0858 0.5036 1
Brugia malayi Latrophilin receptor protein 2 0.0047 0.0212 0.0577
Trypanosoma brucei ubiquitin-protein ligase, putative 0.0031 0.0118 0.0694
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0141 0.077 0.153
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0299 0.1712 0.414
Loa Loa (eye worm) hypothetical protein 0.009 0.0463 0.1275
Echinococcus multilocularis PHD finger protein rhinoceros 0.003 0.0108 0.0215
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0299 0.1712 1
Schistosoma mansoni hypothetical protein 0.003 0.0108 0.021
Loa Loa (eye worm) MBCTL1 0.004 0.0168 0.0457
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0299 0.1712 1
Trypanosoma cruzi trans-sialidase, putative 0.0024 0.0072 0.0631
Mycobacterium ulcerans hypothetical protein 0.0106 0.0561 0.0524
Trypanosoma brucei trans-sialidase, putative 0.0024 0.0072 0.0291
Echinococcus multilocularis histone acetyltransferase MYST2 0.004 0.0168 0.0333
Schistosoma mansoni ubiquitin conjugating enzyme 13 0.0031 0.0118 0.0229
Schistosoma mansoni hypothetical protein 0.0209 0.1171 0.2321
Plasmodium vivax hypothetical protein, conserved 0.0018 0.0038 0.0624
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0012 0.0003 0.0005
Echinococcus granulosus PHD finger protein rhinoceros 0.003 0.0108 0.0215
Schistosoma mansoni glutaminase 0.0201 0.1124 0.2227
Echinococcus multilocularis phd:f box containing protein 0.0026 0.0083 0.0166
Brugia malayi Bromodomain containing protein 0.003 0.0108 0.0291
Onchocerca volvulus 0.0106 0.0561 0.1357
Echinococcus multilocularis geminin 0.0858 0.5036 1
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0099 0.0233
Mycobacterium tuberculosis Conserved protein 0.0106 0.0561 0.0558
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0012 0.0003 0.0005
Entamoeba histolytica hypothetical protein, conserved 0.0054 0.0254 0.147
Echinococcus multilocularis cpg binding protein 0.0033 0.0124 0.0247
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0026 0.0083 0.0455
Giardia lamblia Protein LRP16 0.0054 0.0254 0.1293
Trichomonas vaginalis ganglioside induced differentiation associated protein, putative 0.0054 0.0254 0.0609
Brugia malayi beta-lactamase family protein 0.0106 0.0561 0.1542
Trichomonas vaginalis D-aminoacylase, putative 0.0106 0.0561 0.1352
Trypanosoma cruzi trans-sialidase, putative 0.0024 0.0072 0.0631
Onchocerca volvulus 0.0106 0.0561 0.1357
Onchocerca volvulus 0.0028 0.0095 0.023
Loa Loa (eye worm) TAR-binding protein 0.0062 0.0297 0.0815
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.009 0.0463 0.092
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0086 0.044 0.0873
Loa Loa (eye worm) hypothetical protein 0.0031 0.0117 0.0318
Mycobacterium ulcerans molybdopterin-guanine dinucleotide biosynthesis protein A 0.031 0.1777 0.1744
Loa Loa (eye worm) histone methyltransferase 0.0013 0.0007 0.0013
Echinococcus multilocularis transcription factor Dp 1 0.0039 0.0163 0.0324
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0027 0.0094 0.0186
Treponema pallidum fructose-bisphosphate aldolase 0.0299 0.1712 0.9627
Schistosoma mansoni hypothetical protein 0.0054 0.0254 0.0499
Loa Loa (eye worm) hypothetical protein 0.0013 0.0007 0.0013
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0047 0.0212 0.0577
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0047 0.0212 0.042
Trypanosoma cruzi trans-sialidase, Group I, putative 0.0024 0.0072 0.0631
Trypanosoma cruzi trans-sialidase, Group I, putative 0.0024 0.0072 0.0631
Schistosoma mansoni jumonji domain containing protein 0.0026 0.0083 0.016
Trichomonas vaginalis chromobox protein, putative 0.0043 0.0187 0.0445
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0297 0.0585
Loa Loa (eye worm) latrophilin receptor protein 2 0.0047 0.0212 0.0579
Brugia malayi latrophilin 2 splice variant baaae 0.0102 0.0538 0.1478
Trypanosoma brucei trans-sialidase, putative 0.0024 0.0072 0.0291
Echinococcus granulosus polycomb protein SCMH1 0.0035 0.0139 0.0275
Onchocerca volvulus 0.0031 0.0114 0.0275
Trypanosoma brucei trans-sialidase 0.0024 0.0072 0.0291
Onchocerca volvulus 0.0031 0.0117 0.0284
Schistosoma mansoni hypothetical protein 0.0047 0.0212 0.0415
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0297 0.0585
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0038 0.0084
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0012 0.0003 0.0005
Schistosoma mansoni cpg binding protein 0.0033 0.0124 0.0241
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.0297 0.0815
Loa Loa (eye worm) hypothetical protein 0.004 0.0169 0.046
Schistosoma mansoni cpg binding protein 0.0033 0.0124 0.0241
Loa Loa (eye worm) hypothetical protein 0.0106 0.0561 0.1544
Echinococcus granulosus ubiquitin conjugating enzyme E2 N 0.0031 0.0118 0.0234
Loa Loa (eye worm) multidrug resistance protein 3 0.0012 0.0003 0.0002
Schistosoma mansoni survival motor neuron protein 0.0049 0.0224 0.0441
Mycobacterium tuberculosis Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU 0.1692 1 1
Trichomonas vaginalis D-aminoacylase, putative 0.0106 0.0561 0.1352
Mycobacterium ulcerans lipase LipD 0.0106 0.0561 0.0524
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0095 0.0255
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0026 0.0083 0.0847
Toxoplasma gondii hypothetical protein 0.0018 0.0038 0.0196
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0012 0.0003 0.0005
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0013 0.0007 0.0013
Loa Loa (eye worm) hypothetical protein 0.0026 0.0083 0.0225
Trypanosoma cruzi hypothetical protein, conserved 0.0106 0.0561 1
Trypanosoma cruzi trans-sialidase, Group I, putative 0.0024 0.0072 0.0631
Toxoplasma gondii histone lysine methyltransferase SET1 0.0062 0.0297 0.1659
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0106 0.0561 0.1109
Loa Loa (eye worm) hypothetical protein 0.0012 0.0003 0.0002
Trichomonas vaginalis penicillin-binding protein, putative 0.0106 0.0561 0.1352
Loa Loa (eye worm) ATP-binding cassette sub-family B member 2 0.0012 0.0003 0.0002
Loa Loa (eye worm) transcription factor SMAD2 0.0118 0.0633 0.1744
Echinococcus multilocularis lamin dm0 0.0028 0.0095 0.0188
Mycobacterium tuberculosis Probable hydrolase 0.0106 0.0561 0.0558
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0106 0.0561 0.0558
Echinococcus granulosus histone lysine methyltransferase setb 0.009 0.0463 0.092
Brugia malayi mbt repeat family protein 0.0035 0.0139 0.0376
Plasmodium vivax hypothetical protein, conserved 0.003 0.0108 0.189
Loa Loa (eye worm) glutaminase 2 0.0201 0.1124 0.3099
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0018 0.0038 0.0122
Echinococcus multilocularis chromobox protein 1 0.0071 0.0355 0.0705
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0299 0.1712 0.414
Leishmania major hypothetical protein, conserved 0.0106 0.0561 1
Chlamydia trachomatis ABC transporter ATP binding protein/permease 0.0012 0.0003 0.5
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0141 0.077 0.153
Plasmodium vivax ubiquitin-conjugating enzyme E2 N, putative 0.0031 0.0118 0.2063
Loa Loa (eye worm) hypothetical protein 0.0106 0.0561 0.1544
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0019 0.0042 0.0094
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0068 0.0333 0.2593
Schistosoma mansoni sex comb on midleg homolog 0.0035 0.0139 0.027
Echinococcus granulosus multidrug resistance protein 1 0.0012 0.0003 0.0005
Mycobacterium tuberculosis Conserved protein 0.0106 0.0561 0.0558
Echinococcus granulosus JmjC domain containing protein 4 0.0026 0.0083 0.0166
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0141 0.077 0.2123
Brugia malayi chromobox protein homolog 3 0.004 0.0169 0.0458
Brugia malayi CXXC zinc finger family protein 0.0031 0.0114 0.0307
Trichomonas vaginalis penicillin-binding protein, putative 0.0106 0.0561 0.1352
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0149 0.0819 0.2255
Entamoeba histolytica hypothetical protein 0.0106 0.0562 0.327
Echinococcus granulosus tar DNA binding protein 0.0062 0.0297 0.059
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0026 0.0083 0.016
Echinococcus multilocularis lysine specific demethylase 5A 0.0096 0.0504 0.1001
Echinococcus multilocularis GPCR, family 2 0.0047 0.0212 0.042
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0021 0.0054 0.0101
Brugia malayi MH2 domain containing protein 0.0118 0.0633 0.1742
Loa Loa (eye worm) hypothetical protein 0.0067 0.0331 0.0908
Trypanosoma brucei Macro domain containing protein, putative 0.0054 0.0254 0.1897
Mycobacterium tuberculosis Probable lipase LipD 0.0106 0.0561 0.0558
Mycobacterium ulcerans hypothetical protein 0.031 0.1777 0.1744
Loa Loa (eye worm) MH2 domain-containing protein 0.0118 0.0633 0.1744
Schistosoma mansoni lamin 0.0028 0.0095 0.0183
Echinococcus granulosus lysine specific demethylase 5A 0.0098 0.0515 0.1022
Echinococcus multilocularis musashi 0.0028 0.0095 0.0188
Echinococcus granulosus multidrug resistance protein 1 0.0012 0.0003 0.0005
Onchocerca volvulus Heterochromatin protein 1 homolog 0.004 0.0169 0.0408
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.001 0.002
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0068 0.0333 0.563
Schistosoma mansoni hypothetical protein 0.0106 0.0562 0.111
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0299 0.1712 0.414
Loa Loa (eye worm) RNA binding protein 0.0062 0.0297 0.0815
Onchocerca volvulus 0.0012 0.0003 0.0007
Loa Loa (eye worm) hypothetical protein 0.0013 0.0007 0.0013
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0039 0.0655
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0106 0.0562 0.1115
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0013 0.0007 0.0013
Brugia malayi glutaminase DH11.1 0.0201 0.1124 0.3098
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0299 0.1712 0.414
Loa Loa (eye worm) jmjC domain-containing protein 0.0026 0.0083 0.0225
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0099 0.0233
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0095 0.0257
Trichomonas vaginalis ganglioside induced differentiation associated protein, putative 0.0054 0.0254 0.0609
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0158 0.0871 0.1729
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0068 0.0333 0.0661
Trichomonas vaginalis chromobox protein, putative 0.0043 0.0187 0.0445
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0015 0.0019 0.004
Mycobacterium ulcerans bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase 0.1692 1 1
Toxoplasma gondii ubiquitin-conjugating enzyme subfamily protein 0.0031 0.0118 0.0649
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0035 0.0139 0.027
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0141 0.077 0.153
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0039 0.0089
Echinococcus multilocularis jumonji domain containing protein 0.0042 0.0178 0.0353
Schistosoma mansoni hypothetical protein 0.0047 0.0212 0.0415
Echinococcus multilocularis tar DNA binding protein 0.0062 0.0297 0.059
Brugia malayi beta-lactamase 0.0106 0.0561 0.1542
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0047 0.0212 0.042
Schistosoma mansoni phd/f-box containing protein 0.0026 0.0083 0.016
Trypanosoma brucei trans-sialidase, putative 0.0024 0.0072 0.0291
Trypanosoma cruzi trans-sialidase, putative 0.0024 0.0072 0.0631
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0039 0.0103
Trichomonas vaginalis esterase, putative 0.0106 0.0561 0.1352
Echinococcus granulosus lamin dm0 0.0028 0.0095 0.0188
Trypanosoma cruzi trans-sialidase, putative 0.0024 0.0072 0.0631
Giardia lamblia PHD finger protein 15 0.003 0.0108 0.0422
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0169 0.0402
Loa Loa (eye worm) jmjC domain-containing protein 0.0098 0.0515 0.1416
Echinococcus granulosus transcription factor Dp 1 0.0039 0.0163 0.0324
Loa Loa (eye worm) jmjC domain-containing protein 0.0026 0.0083 0.0225
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.004 0.0168 0.0333
Brugia malayi TAR-binding protein 0.0062 0.0297 0.0813
Trypanosoma cruzi trans-sialidase, putative 0.0024 0.0072 0.0631
Schistosoma mansoni myelin transcription factor 1 myt1 0.004 0.0168 0.0327
Schistosoma mansoni hypothetical protein 0.0858 0.5036 1
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0019 0.0042 0.0094
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0012 0.0003 0.0005
Trypanosoma cruzi trans-sialidase, Group I, putative 0.0024 0.0072 0.0631
Brugia malayi jmjC domain containing protein 0.0026 0.0083 0.0223
Echinococcus granulosus chromobox protein 1 0.0071 0.0355 0.0705
Loa Loa (eye worm) hypothetical protein 0.0013 0.001 0.0022
Schistosoma mansoni transcription factor LCR-F1 0.0106 0.0562 0.111
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0108 0.0594
Echinococcus granulosus peregrin 0.003 0.0108 0.0215
Echinococcus multilocularis SAM and MBT domain containing protein 0.0035 0.0139 0.0275
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0106 0.0561 0.1544
Echinococcus granulosus histone acetyltransferase MYST2 0.004 0.0168 0.0333
Echinococcus multilocularis ubiquitin conjugating enzyme E2 N 0.0031 0.0118 0.0234
Loa Loa (eye worm) PHD-finger family protein 0.003 0.0108 0.0294
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0106 0.0561 0.1542
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0146 0.0801 0.0254
Mycobacterium tuberculosis Possible lipoprotein LppD 0.0054 0.0254 0.0251
Brugia malayi beta-lactamase family protein 0.0106 0.0561 0.1542
Loa Loa (eye worm) hypothetical protein 0.0106 0.0561 0.1544
Loa Loa (eye worm) hypothetical protein 0.0054 0.0254 0.0696
Echinococcus granulosus lysine specific demethylase 6a 0.0026 0.0083 0.0166
Loa Loa (eye worm) heterochromatin protein 1 0.0071 0.0355 0.0976
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0141 0.077 0.2121
Trichomonas vaginalis ganglioside induced differentiation associated protein, putative 0.0054 0.0254 0.0609
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0019 0.0046
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0069 0.0339 0.0667
Echinococcus granulosus multidrug resistance protein 1 0.0012 0.0003 0.0005
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0101 0.0533 0.1053
Schistosoma mansoni ap endonuclease 0.0018 0.0039 0.0073
Schistosoma mansoni jumonji/arid domain-containing protein 0.0098 0.0515 0.1017
Trichomonas vaginalis chromobox protein, putative 0.0071 0.0355 0.0854
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0027 0.0094 0.0186
Loa Loa (eye worm) CXXC zinc finger family protein 0.0031 0.0114 0.0309
Loa Loa (eye worm) ubiquitin conjugating enzyme protein 13 0.0031 0.0118 0.032
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0106 0.0561 0.1109
Schistosoma mansoni lamin 0.0028 0.0095 0.0183
Loa Loa (eye worm) hypothetical protein 0.0012 0.0003 0.0002
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0042 0.0094
Plasmodium falciparum phd finger protein, putative 0.003 0.0108 0.0369
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0012 0.0003 0.0005
Brugia malayi jmjC domain containing protein 0.0026 0.0083 0.0223
Leishmania major ubiquitin-conjugating enzyme e2, putative 0.0031 0.0118 0.2063
Mycobacterium tuberculosis Probable esterase LipL 0.0106 0.0561 0.0558
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0149 0.0819 0.2256
Brugia malayi jmjC domain containing protein 0.0026 0.0083 0.0223
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0297 0.0585
Mycobacterium ulcerans hypothetical protein 0.031 0.1777 0.1744
Echinococcus granulosus GPCR family 2 0.0047 0.0212 0.042
Mycobacterium tuberculosis Conserved hypothetical protein 0.031 0.1777 0.1775
Brugia malayi PHD-finger family protein 0.003 0.0108 0.0291
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.009 0.0463 0.2596
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0106 0.0562 0.1115
Plasmodium vivax hypothetical protein, conserved 0.0054 0.0254 0.4504
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0015 0.0022 0.0047
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0018 0.0039 0.0214
Trypanosoma cruzi trans-sialidase, Group I, putative 0.0024 0.0072 0.0631
Trypanosoma cruzi trans-sialidase, Group I, putative 0.0024 0.0072 0.0631
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0042 0.0094
Echinococcus multilocularis jumonji domain containing 1A 0.0026 0.0083 0.0166
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0012 0.0003 0.0005
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.0031 0.0118 0.0279
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0141 0.077 0.1525
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.0297 0.0813
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0042 0.0094
Plasmodium vivax SET domain protein, putative 0.009 0.0463 0.8254
Mycobacterium ulcerans glutaminase 0.0201 0.1124 0.1089
Echinococcus granulosus SAM and MBT domain containing protein 0.0035 0.0139 0.0275
Echinococcus granulosus MACRO domain containing protein 2 0.0054 0.0254 0.0504
Trichomonas vaginalis glutaminase, putative 0.0201 0.1124 0.2715
Brugia malayi Pre-SET motif family protein 0.009 0.0463 0.1273
Trypanosoma cruzi trans-sialidase, Group I, putative 0.0024 0.0072 0.0631
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0141 0.077 0.1525
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0026 0.0083 0.039
Plasmodium vivax hypothetical protein, conserved 0.0106 0.0561 1
Trypanosoma cruzi Macro domain containing protein, putative 0.0054 0.0254 0.4118
Echinococcus multilocularis MACRO domain containing protein 2 0.0054 0.0254 0.0504
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0042 0.0094
Brugia malayi intermediate filament protein 0.0028 0.0095 0.0255
Giardia lamblia Fructose-bisphosphate aldolase 0.0299 0.1712 1
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0106 0.0561 0.0558
Trypanosoma brucei RNA helicase, putative 0.0209 0.1171 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0018 0.0038 0.0035
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0493 0.2862 1
Schistosoma mansoni hypothetical protein 0.0102 0.0538 0.1063
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0068 0.0333 0.563
Loa Loa (eye worm) hypothetical protein 0.0106 0.0561 0.1544
Entamoeba histolytica hypothetical protein, conserved 0.0054 0.0254 0.147
Trypanosoma cruzi trans-sialidase, Group I, putative 0.0024 0.0072 0.0631
Onchocerca volvulus 0.0049 0.0224 0.0543
Toxoplasma gondii eukaryotic initiation factor-2B, gamma subunit, putative 0.031 0.1777 1
Brugia malayi jmjC domain containing protein 0.0098 0.0515 0.1414
Mycobacterium ulcerans lipoprotein LppD 0.0054 0.0254 0.0216
Plasmodium falciparum Appr-1-p processing domain protein 0.0054 0.0254 0.0879
Toxoplasma gondii macro domain-containing protein 0.0054 0.0254 0.1417
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0026 0.0083 0.0455
Echinococcus multilocularis H2A histone family, member Y 0.0018 0.0038 0.0075
Brugia malayi RNA binding protein 0.0062 0.0297 0.0813
Onchocerca volvulus 0.0101 0.0533 0.129
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0043 0.0187 0.0452
Brugia malayi jmjC domain containing protein 0.0158 0.0871 0.2399
Leishmania major hypothetical protein, conserved 0.0026 0.0083 0.1446
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0018 0.0038 0.0122
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0299 0.1712 0.414
Loa Loa (eye worm) hypothetical protein 0.0106 0.0561 0.1544
Schistosoma mansoni ap endonuclease 0.0018 0.0039 0.0073
Schistosoma mansoni jumonji domain containing protein 0.0138 0.0751 0.1487
Schistosoma mansoni hypothetical protein 0.0216 0.1218 0.2415
Brugia malayi jmjC domain containing protein 0.0026 0.0083 0.0223
Echinococcus granulosus lamin 0.0028 0.0095 0.0188
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0106 0.0561 0.0558
Trypanosoma cruzi trans-sialidase, putative 0.0024 0.0072 0.0631
Toxoplasma gondii exonuclease III APE 0.0018 0.0039 0.0206
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0039 0.0089
Schistosoma mansoni chromobox protein 0.0071 0.0355 0.07
Onchocerca volvulus Alhambra homolog 0.003 0.0108 0.0262
Plasmodium vivax JmjC domain containing protein 0.0026 0.0083 0.1446
Trypanosoma brucei trans-sialidase, putative 0.0024 0.0072 0.0291
Schistosoma mansoni hypothetical protein 0.0858 0.5036 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0299 0.1712 0.414
Loa Loa (eye worm) hypothetical protein 0.0035 0.0139 0.0378
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0068 0.0333 0.0661
Echinococcus granulosus phd:f box containing protein 0.0026 0.0083 0.0166
Echinococcus granulosus MACRO domain containing protein 2 0.0054 0.0254 0.0504
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0012 0.0003 0.0005

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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