TDR Targets

Basic information

Technical information

TDR Targets ID: 625630
Name: 2-[(4-chlorophenyl)methylsulfanyl]-1-(4-nitro phenyl)sulfonyl-4,5-dihydroimidazole
MW: 411.883 | Formula: C16H14ClN3O4S2
H donors: 0 H acceptors: 4 LogP: 3.43 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: Clc1ccc(cc1)CSC1=NCCN1S(=O)(=O)c1ccc(cc1)[N+](=O)[O-]
InChi: 1S/C16H14ClN3O4S2/c17-13-3-1-12(2-4-13)11-25-16-18-9-10-19(16)26(23,24)15-7-5-14(6-8-15)20(21)22/h1-8H,9-11H2
InChiKey: NVFOILSIDQYDOR-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

2-[(4-chlorophenyl)methylthio]-1-(4-nitrophenyl)sulfonyl-4,5-dihydroimidazole
2-[(4-chlorobenzyl)thio]-1-(4-nitrophenyl)sulfonyl-4,5-dihydroimidazole
ZINC02711531

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	cpg binding protein	0.0034	0.0329	0.0374
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0184	0.2203	1
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0027	0.0251	0.0284
Schistosoma mansoni	receptor protein tyrosine phosphatase n (ia2)	0.0027	0.0251	0.0439
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0074	0.0833	0.0936
Mycobacterium ulcerans	acyl-CoA synthetase	0.0022	0.0181	0.0037
Brugia malayi	AMP-binding enzyme family protein	0.0074	0.0833	0.2465
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0027	0.0251	0.0678
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0251	0.0674
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0074	0.0833	0.213
Schistosoma mansoni	ap endonuclease	0.0021	0.0169	0.029
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.001	0.0033	0.0028
Entamoeba histolytica	protein tyrosine phosphatase, putative	0.0027	0.0251	0.0228
Onchocerca volvulus		0.0027	0.0251	0.0735
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0251	0.0674
Trypanosoma brucei	low molecular weight protein tyrosine phosphatase, putative	0.0067	0.0741	0.1563
Echinococcus multilocularis	acetyl coenzyme A synthetase, cytoplasmic	0.0022	0.0181	0.0173
Loa Loa (eye worm)	AMP-binding enzyme family protein	0.0022	0.0181	0.0456
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0032	0.0306	0.0841
Onchocerca volvulus		0.0027	0.0251	0.0735
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0027	0.0251	0.0678
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.0055	0.0599	0.5
Brugia malayi	CXXC zinc finger family protein	0.0032	0.0306	0.0846
Leishmania major	hypothetical protein, conserved	0.0014	0.0089	0.0208
Onchocerca volvulus		0.0027	0.0251	0.0735
Mycobacterium ulcerans	acyl-CoA synthetase	0.0022	0.0181	0.0037
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0027	0.0251	0.0674
Schistosoma mansoni	sumo-1-activating enzyme E1a	0.0056	0.0605	0.1076
Onchocerca volvulus		0.0027	0.0251	0.0735
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0027	0.0251	0.0243
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0251	0.0674
Brugia malayi	glutaminase DH11.1	0.0271	0.3283	1
Echinococcus multilocularis	receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type	0.0027	0.0251	0.0243
Echinococcus granulosus	receptor type tyrosine protein phosphatase zeta	0.0027	0.0251	0.0284
Loa Loa (eye worm)	phosphotyrosine protein phosphatase	0.0217	0.2606	0.7917
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.0067	0.0741	0.0825
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0027	0.0251	0.0678
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0027	0.0251	0.0678
Mycobacterium ulcerans	phosphotyrosine protein phosphatase PtpA	0.0217	0.2606	0.7825
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0074	0.0833	0.3347
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0021	0.0169	0.0188
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0027	0.0251	0.0674
Toxoplasma gondii	small ubiquitin family modifier, putative	0.0036	0.0352	0.4607
Loa Loa (eye worm)	oxidoreductase	0.0022	0.0181	0.0456
Onchocerca volvulus		0.0074	0.0833	0.3022
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0181	0.0456
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0027	0.0251	0.0243
Schistosoma mansoni	non-receptor protein-tyrosine phosphatase	0.0027	0.0251	0.0439
Schistosoma mansoni	sumo-1-activating enzyme E1a	0.0051	0.0541	0.0961
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.0217	0.2606	0.3099
Echinococcus granulosus	receptor type tyrosine protein phosphatase zeta	0.0027	0.0251	0.0284
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.0217	0.2606	0.3099
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0474	0.0841
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0045	0.0474	0.1364
Onchocerca volvulus		0.0027	0.0251	0.0735
Mycobacterium ulcerans	acyl-CoA synthetase	0.0074	0.0833	0.213
Schistosoma mansoni	cpg binding protein	0.0034	0.0329	0.0578
Loa Loa (eye worm)	dual specificity protein phosphatase CDC14B	0.0027	0.0251	0.0674
Brugia malayi	Low molecular weight phosphotyrosine protein phosphatase containing protein	0.0217	0.2606	0.7918
Onchocerca volvulus		0.0027	0.0251	0.0735
Schistosoma mansoni	receptor protein tyrosine phosphatase	0.0027	0.0251	0.0439
Trichomonas vaginalis	antibiotic synthetase, putative	0.0022	0.0181	0.0142
Onchocerca volvulus		0.0022	0.0181	0.0457
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0251	0.0674
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0251	0.0674
Plasmodium falciparum	acetyl-CoA synthetase, putative	0.0022	0.0181	0.1784
Brugia malayi	exodeoxyribonuclease III family protein	0.0021	0.0169	0.0426
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0027	0.0251	0.0678
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0027	0.0251	0.0678
Plasmodium vivax	acetyl-CoA synthetase, putative	0.0022	0.0181	0.1784
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0157	0.187	0.1863
Trichomonas vaginalis	pten, drome, putative	0.0027	0.0251	0.0228
Giardia lamblia	Ubiquitin-activating enzyme E1 1	0.0017	0.0127	0.0151
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.035	0.4263	1
Mycobacterium tuberculosis	Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase	0.0022	0.0181	0.0183
Mycobacterium tuberculosis	Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0022	0.0181	0.0183
Trypanosoma brucei	small ubiquitin-related modifier	0.0036	0.0352	0.0631
Echinococcus granulosus	Small ubiquitin modifier 2	0.0036	0.0352	0.0402
Mycobacterium ulcerans	long-chain-acyl-CoA synthetase	0.0022	0.0181	0.0037
Schistosoma mansoni	hypothetical protein	0.0453	0.5551	1
Echinococcus granulosus	acetyl coenzyme A synthetase cytoplasmic	0.0022	0.0181	0.0202
Onchocerca volvulus		0.0027	0.0251	0.0735
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0027	0.0251	0.0678
Onchocerca volvulus		0.0027	0.0251	0.0735
Echinococcus granulosus	dnaJ subfamily B	0.0453	0.5551	0.6477
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0065	0.0099
Trypanosoma brucei	mitochondrial DNA polymerase beta-PAK	0.0165	0.197	0.4507
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.001	0.0033	0.0024
Schistosoma mansoni	nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if)	0.0014	0.0089	0.0145
Toxoplasma gondii	ThiF family protein	0.0037	0.0367	0.487
Leishmania major	long-chain-fatty-acid-CoA ligase, putative	0.0022	0.0181	0.0424
Trypanosoma cruzi	acetyl-CoA synthetase, putative	0.0022	0.0181	0.0424
Leishmania major	4-coumarate:coa ligase-like protein	0.0074	0.0833	0.1953
Echinococcus granulosus	Receptor type tyrosine protein phosphatase O	0.0027	0.0251	0.0284
Trypanosoma cruzi	tyrosine specific protein phosphatase, putative	0.0027	0.0251	0.059
Echinococcus granulosus	Carboxy terminal domain RNA polymerase II	0.0014	0.0089	0.0094
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0021	0.0169	0.1561
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0251	0.0674
Loa Loa (eye worm)	AMP-binding enzyme family protein	0.0022	0.0181	0.0456
Toxoplasma gondii	exonuclease III APE	0.0021	0.0169	0.1409
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0021	0.0169	0.0128
Brugia malayi	hypothetical protein	0.0027	0.0251	0.0678
Mycobacterium ulcerans	acyl-CoA synthetase	0.0074	0.0833	0.213
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0089	0.0173
Schistosoma mansoni	cpg binding protein	0.0032	0.0306	0.0537
Mycobacterium ulcerans	acyl-CoA synthetase	0.0074	0.0833	0.213
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0052	0.0562	0.2032
Schistosoma mansoni	protein-tyrosine phosphatase non-receptor type nt5	0.0027	0.0251	0.0439
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0251	0.0674
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0052	0.0562	0.2032
Onchocerca volvulus		0.0022	0.0181	0.0457
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0027	0.0251	0.0674
Echinococcus multilocularis	Carboxy terminal domain RNA polymerase II	0.0014	0.0089	0.0081
Loa Loa (eye worm)	SMO-1 protein	0.0036	0.0352	0.0983
Schistosoma mansoni	nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if)	0.0014	0.0089	0.0145
Trypanosoma cruzi	acetyl-CoA synthetase, putative	0.0022	0.0181	0.0424
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0027	0.0251	0.0284
Loa Loa (eye worm)	fibronectin type III domain-containing protein	0.0027	0.0251	0.0674
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0251	0.0674
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0251	0.0674
Onchocerca volvulus		0.0217	0.2606	1
Trichomonas vaginalis	dullard protein, putative	0.0014	0.0089	0.0029
Brugia malayi	acetyl-Coenzyme A synthetase 2	0.0022	0.0181	0.0461
Mycobacterium ulcerans	hypothetical protein	0.0184	0.2203	0.6531
Trichomonas vaginalis	nuclear lim interactor-interacting factor, putative	0.0014	0.0089	0.0029
Mycobacterium ulcerans	acyl-CoA synthetase	0.0022	0.0181	0.0037
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0251	0.0674
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0027	0.0251	0.0674
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0021	0.0169	0.0397
Echinococcus multilocularis	receptor type tyrosine protein phosphatase zeta	0.0027	0.0251	0.0243
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0027	0.0251	0.0678
Schistosoma mansoni	protein tyrosine phosphatase non-receptor type nt1	0.0027	0.0251	0.0439
Entamoeba histolytica	ubiquitin-activating enzyme, putative	0.0017	0.0127	0.0076
Trypanosoma cruzi	ubiquitin-activating enzyme, putative	0.0037	0.0367	0.0861
Schistosoma mansoni	rgs-gaip interacting protein gipc	0.0027	0.0251	0.0439
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0027	0.0251	0.0678
Toxoplasma gondii	AMP-binding enzyme domain-containing protein	0.0022	0.0181	0.1611
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0022	0.0181	0.0183
Toxoplasma gondii	hypothetical protein	0.0056	0.0612	0.9155
Echinococcus multilocularis	dnaJ subfamily B	0.0453	0.5551	0.5547
Schistosoma mansoni	hypothetical protein	0.0014	0.0087	0.0141
Onchocerca volvulus		0.0027	0.0251	0.0735
Leishmania major	acetyl-CoA synthetase, putative	0.0022	0.0181	0.0424
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0027	0.0251	0.0243
Schistosoma mansoni	protein tyrosine phosphatase	0.0027	0.0251	0.0439
Trichomonas vaginalis	glutaminase, putative	0.0271	0.3283	0.3925
Schistosoma mansoni	cpg binding protein	0.0034	0.0329	0.0578
Schistosoma mansoni	pcd6 interacting protein-related	0.0027	0.0251	0.0439
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0251	0.0674
Brugia malayi	Protein-tyrosine phosphatase 1	0.0027	0.0251	0.0678
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0027	0.0251	0.0674
Echinococcus multilocularis	hypothetical protein	0.0027	0.0251	0.0243
Trypanosoma cruzi	long-chain-fatty-acid-CoA ligase, putative	0.0022	0.0181	0.0424
Echinococcus multilocularis	receptor type tyrosine protein phosphatase H	0.0027	0.0251	0.0243
Brugia malayi	hypothetical protein	0.0027	0.0251	0.0678
Plasmodium falciparum	small ubiquitin-related modifier	0.0036	0.0352	0.5104
Entamoeba histolytica	NLI interacting factor-like phosphatase domain-containing protein	0.0014	0.0089	0.0029
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0027	0.0251	0.0678
Trypanosoma brucei	long-chain-fatty-acid-CoA ligase, putative	0.0022	0.0181	0.0221
Plasmodium vivax	SUMO-activating enzyme subunit 2, putative	0.0037	0.0367	0.5394
Schistosoma mansoni	protein tyrosine phosphatase	0.0027	0.0251	0.0439
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0027	0.0251	0.0674
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.0474	0.0466
Echinococcus granulosus	ubiquitin	0.0012	0.0065	0.0066
Echinococcus multilocularis		0.0027	0.0251	0.0243
Leishmania major	acetyl-CoA synthetase, putative	0.0022	0.0181	0.0424
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0027	0.0251	0.0678
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0027	0.0251	0.0678
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0027	0.0251	0.0674
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0021	0.0169	0.5
Echinococcus multilocularis	receptor type tyrosine protein phosphatase F	0.0027	0.0251	0.0243
Mycobacterium tuberculosis	Probable peptide synthetase Nrp (peptide synthase)	0.0022	0.0181	0.0183
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0027	0.0251	0.0674
Echinococcus multilocularis	ubiquitin	0.0012	0.0065	0.0056
Plasmodium falciparum	SUMO-activating enzyme subunit 1	0.0056	0.0605	1
Toxoplasma gondii	histone lysine methyltransferase SET1	0.006	0.066	1
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0181	0.0456
Brugia malayi	ThiF family protein	0.0056	0.0605	0.1764
Schistosoma mansoni	glutaminase	0.0271	0.3283	0.5908
Mycobacterium tuberculosis	Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase)	0.0022	0.0181	0.0183
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0157	0.187	0.2175
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0074	0.0833	1
Brugia malayi	ThiF family protein	0.0037	0.0367	0.1034
Entamoeba histolytica	Pten 3-phosphoinositide phosphatase, putative	0.0027	0.0251	0.0228
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0021	0.0169	0.0127
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0027	0.0251	0.0284
Toxoplasma gondii	hypothetical protein	0.0056	0.0605	0.9028
Trichomonas vaginalis	low molecular weight protein-tyrosine-phosphatase, putative	0.0217	0.2606	0.3099
Trypanosoma cruzi	small ubiquitin protein, putative	0.0036	0.0352	0.0826
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0027	0.0251	0.0678
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0027	0.0251	0.0243
Schistosoma mansoni	ubiquitin-activating enzyme E1b	0.0037	0.0367	0.0647
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0157	0.187	0.1863
Trypanosoma brucei	DNA polymerase beta thumb, putative	0.0049	0.0522	0.1038
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0067	0.075	0.1338
Loa Loa (eye worm)	protein-tyrosine phosphatase 1	0.0027	0.0251	0.0674
Entamoeba histolytica	long-chain-fatty-acid--CoA ligase, putative	0.0022	0.0181	0.0142
Schistosoma mansoni	acetyl-CoA synthetase	0.0022	0.0181	0.0311
Trichomonas vaginalis	ap endonuclease, putative	0.0021	0.0169	0.0128
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0021	0.0169	0.0193
Echinococcus granulosus	sumo-activating enzyme subunit 2	0.0037	0.0367	0.0419
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0027	0.0251	0.0439
Leishmania major	tyrosine specific protein phosphatase, putative	0.0027	0.0251	0.059
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0027	0.0251	0.0439
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0605	0.176
Brugia malayi	hypothetical protein	0.0027	0.0251	0.0678
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0074	0.0833	0.0936
Echinococcus multilocularis	SUMO activating enzyme subunit 1	0.0056	0.0605	0.0597
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0251	0.0674
Echinococcus multilocularis	protein tyrosine phosphatase n9	0.0027	0.0251	0.0243
Plasmodium vivax	ubiquitin activating enzyme, putative	0.0056	0.0605	1
Trypanosoma cruzi	ubiquitin-activating enzyme, putative	0.0032	0.0303	0.0712
Schistosoma mansoni	protein tyrosine phosphatase	0.0027	0.0251	0.0439
Entamoeba histolytica	acyl-coA synthetase, putative	0.0074	0.0833	0.0936
Leishmania major	ubiquitin-activating enzyme-like protein	0.0037	0.0367	0.0861
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0027	0.0251	0.0243
Trypanosoma brucei	acetyl-CoA synthetase, putative	0.0022	0.0181	0.0221
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0251	0.0674
Loa Loa (eye worm)	protein-tyrosine-phosphatase	0.0027	0.0251	0.0674
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0052	0.0562	0.2032
Leishmania major	mitochondrial DNA polymerase beta	0.035	0.4263	1
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.0217	0.2606	0.3099
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0599	0.1744
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0599	0.1744
Echinococcus granulosus	SUMO activating enzyme subunit 1	0.0056	0.0605	0.0697
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0021	0.0169	0.1561
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0251	0.0674
Schistosoma mansoni	ap endonuclease	0.0021	0.0169	0.029
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0027	0.0251	0.0678
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0027	0.0251	0.0674
Trypanosoma brucei	ubiquitin-activating enzyme E1, putative	0.0037	0.0367	0.0667
Brugia malayi	protein-tyrosine phosphatase Lar-like precursor, putative	0.0027	0.0251	0.0678
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0251	0.0674
Mycobacterium ulcerans	acyl-CoA synthetase	0.0022	0.0181	0.0037
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0027	0.0251	0.0439
Trypanosoma cruzi	tyrosine specific protein phosphatase, putative	0.0027	0.0251	0.059
Onchocerca volvulus		0.0027	0.0251	0.0735
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0157	0.187	0.5655
Entamoeba histolytica	ubiquitin like protein	0.0036	0.0352	0.0351
Mycobacterium ulcerans	acyl-CoA synthetase	0.0022	0.0181	0.0037
Mycobacterium ulcerans	acetyl-CoA synthetase	0.0022	0.0181	0.0037
Trypanosoma cruzi	long-chain-fatty-acid-CoA ligase, putative	0.0022	0.0181	0.0424
Trichomonas vaginalis	low molecular weight protein-tyrosine-phosphatase, putative	0.0217	0.2606	0.3099
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.0474	0.0545
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0157	0.187	0.5653
Mycobacterium tuberculosis	Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0022	0.0181	0.0183
Echinococcus multilocularis		0.0014	0.0089	0.0081
Trypanosoma brucei	protein tyrosine phosphatase 1	0.0027	0.0251	0.039
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0027	0.0251	0.0674
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0251	0.0674
Onchocerca volvulus		0.0022	0.0181	0.0457
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0251	0.0674
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0474	0.0841
Leishmania major	protein-tyrosine phosphatase 1-like protein	0.0027	0.0251	0.059
Echinococcus granulosus	CTD small phosphatase protein like	0.0014	0.0089	0.0094
Echinococcus multilocularis	cpg binding protein	0.0034	0.0329	0.0321
Leishmania major	hypothetical protein, conserved	0.0067	0.0741	0.1738
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0157	0.187	0.2175
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0027	0.0251	0.0243
Trypanosoma cruzi	hypothetical protein, conserved	0.0067	0.0741	0.1738
Brugia malayi	Dual specificity protein phosphatase CDC14B	0.0027	0.0251	0.0678
Plasmodium falciparum	acyl-CoA synthetase	0.0055	0.0599	0.9896
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0251	0.0674
Trypanosoma cruzi	tyrosine specific protein phosphatase, putative	0.0027	0.0251	0.059
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0027	0.0251	0.0243
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0027	0.0251	0.0243
Mycobacterium tuberculosis	Phenyloxazoline synthase MbtB (phenyloxazoline synthetase)	0.0022	0.0181	0.0183
Echinococcus multilocularis	receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type	0.0027	0.0251	0.0243
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0027	0.0251	0.0678
Onchocerca volvulus		0.0027	0.0251	0.0735
Giardia lamblia	Low molecular weight protein-tyrosine-phosphatase	0.0217	0.2606	1
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0074	0.0833	0.3347
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0027	0.0251	0.0674
Brugia malayi	AMP-binding enzyme family protein	0.0022	0.0181	0.0461
Schistosoma mansoni	ubiquitin-like protein sumo/smt3-related	0.0036	0.0352	0.062
Mycobacterium tuberculosis	Peptide synthetase MbtE (peptide synthase)	0.0022	0.0181	0.0183
Onchocerca volvulus		0.0027	0.0251	0.0735
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0251	0.0674
Echinococcus multilocularis	receptor type tyrosine protein phosphatase zeta	0.0027	0.0251	0.0243
Schistosoma mansoni	protein-tyrosine phosphatase n9	0.0027	0.0251	0.0439
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0027	0.0251	0.0284
Loa Loa (eye worm)	protein tyrosine phosphatase	0.0027	0.0251	0.0674
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.0474	0.0545
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0027	0.0251	0.0284
Toxoplasma gondii	Acetyl-coenzyme A synthetase 2, putative	0.0022	0.0181	0.1611
Onchocerca volvulus		0.0027	0.0251	0.0735
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0055	0.0599	0.2215
Trypanosoma brucei	mitochondrial DNA polymerase beta	0.035	0.4263	1
Mycobacterium tuberculosis	Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase)	0.015	0.1775	0.7922
Schistosoma mansoni	receptor protein tyrosine phosphatase n (ia2)	0.0027	0.0251	0.0439
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0027	0.0251	0.0284
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0027	0.0251	0.0678
Entamoeba histolytica	protein tyrosine phosphatase, putative	0.0217	0.2606	0.3099
Brugia malayi	hypothetical protein	0.0027	0.0251	0.0678
Leishmania major	small ubiquitin protein, putative	0.0036	0.0352	0.0826
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0027	0.0251	0.0674
Onchocerca volvulus		0.0027	0.0251	0.0735
Echinococcus granulosus	Receptor type tyrosine protein phosphatase O	0.0695	0.8566	1
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0021	0.0169	0.5
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0833	0.2461
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0251	0.0674
Loa Loa (eye worm)	ThiF family protein	0.0037	0.0367	0.1029
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0021	0.0169	0.0397
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0251	0.0674
Trypanosoma cruzi	small ubiquitin protein, putative	0.0036	0.0352	0.0826
Brugia malayi	Carboxy-terminal domain RNA polymerase II polypeptide A smallphosphatase 1	0.0014	0.0089	0.0178
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.006	0.0656	0.1539
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0021	0.0169	0.0397
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0074	0.0833	1
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0022	0.0181	0.0461
Onchocerca volvulus		0.0027	0.0251	0.0735
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0474	0.0841
Echinococcus granulosus	protein tyrosine phosphatase n9	0.0027	0.0251	0.0284
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0027	0.0251	0.0243
Entamoeba histolytica	protein tyrosine phosphatase, putative	0.0217	0.2606	0.3099
Brugia malayi	Protein-tyrosine phosphatase	0.0027	0.0251	0.0678
Plasmodium vivax	small ubiquitin-related modifier, putative	0.0036	0.0352	0.5104
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0049	0.0522	0.1225
Mycobacterium ulcerans	acyl-CoA synthetase	0.0022	0.0181	0.0037
Giardia lamblia	Sentrin	0.0036	0.0352	0.1046
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0027	0.0251	0.0243
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0027	0.0251	0.0284
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0251	0.0674
Trichomonas vaginalis	antibiotic synthetase, putative	0.0022	0.0181	0.0142
Onchocerca volvulus		0.0032	0.0306	0.095
Onchocerca volvulus	4.1 G protein, putative homolog	0.0027	0.0251	0.0735
Giardia lamblia	Protein tyrosine phosphatase	0.0027	0.0251	0.0646
Trichomonas vaginalis	conserved hypothetical protein	0.0036	0.0352	0.0351
Plasmodium vivax	acyl-CoA synthetase, putative	0.0055	0.0599	0.9896
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0045	0.0474	0.1359
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0251	0.0674
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0599	0.1744
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0022	0.0181	0.0037
Mycobacterium ulcerans	bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase	0.0022	0.0181	0.0037
Trichomonas vaginalis	dullard protein, putative	0.0014	0.0089	0.0029
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0074	0.0833	0.213
Leishmania major	mitochondrial DNA polymerase beta-PAK, putative	0.0165	0.197	0.4621
Trichomonas vaginalis	dullard protein, putative	0.0014	0.0089	0.0029
Loa Loa (eye worm)	glutaminase	0.0271	0.3283	1
Onchocerca volvulus		0.0027	0.0251	0.0735
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0074	0.0833	0.213
Onchocerca volvulus		0.0027	0.0251	0.0735
Mycobacterium ulcerans	acyl-CoA synthetase	0.0022	0.0181	0.0037
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0052	0.0562	0.2032
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0021	0.0169	0.032
Trichomonas vaginalis	ap endonuclease, putative	0.0021	0.0169	0.0128
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0021	0.0169	0.0161
Mycobacterium tuberculosis	Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0022	0.0181	0.0183
Trypanosoma cruzi	ubiquitin-activating enzyme-like protein	0.0017	0.0127	0.0297
Leishmania major	4-coumarate:coa ligase-like protein	0.0074	0.0833	0.1953
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0599	0.1744
Trypanosoma cruzi	hypothetical protein, conserved	0.0014	0.0089	0.0208
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0027	0.0251	0.0678
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0055	0.0599	0.1381
Trichomonas vaginalis	molybdopterin biosynthesis moeb protein, putative	0.0017	0.0127	0.0076
Onchocerca volvulus		0.0027	0.0251	0.0735
Onchocerca volvulus		0.0027	0.0251	0.0735
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0027	0.0251	0.0678
Mycobacterium ulcerans	phenyloxazoline synthase MbtB	0.0022	0.0181	0.0037
Onchocerca volvulus		0.0027	0.0251	0.0735
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0021	0.0169	0.0421
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0027	0.0251	0.0439
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0027	0.0251	0.0243
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0833	0.2461
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.0157	0.187	0.3359
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0027	0.0251	0.0678
Mycobacterium ulcerans	non-ribosomal peptide synthetase MbtF	0.0022	0.0181	0.0037
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0027	0.0251	0.0678
Mycobacterium ulcerans	O-succinylbenzoic acid--CoA ligase	0.0022	0.0181	0.0037
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0027	0.0251	0.0284
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0027	0.0251	0.0678
Mycobacterium ulcerans	hypothetical protein	0.0074	0.0833	0.213
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0165	0.197	0.4621
Brugia malayi	AMP-binding enzyme family protein	0.0022	0.0181	0.0461
Trichomonas vaginalis	pps1 dual specificty phosphatase, putative	0.0671	0.8265	1
Onchocerca volvulus		0.0027	0.0251	0.0735
Brugia malayi	AMP-binding enzyme family protein	0.0022	0.0181	0.0461
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0027	0.0251	0.0284
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0027	0.0251	0.0674
Brugia malayi	AMP-binding enzyme family protein	0.0074	0.0833	0.2465
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0074	0.0833	0.213
Schistosoma mansoni	receptor protein tyrosine phosphatase r (pcptp1)	0.0027	0.0251	0.0439
Mycobacterium ulcerans	non-ribosomal peptide synthetase MbtE	0.0022	0.0181	0.0037
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.0474	0.0466
Trichomonas vaginalis	low molecular weight protein-tyrosine-phosphatase, putative	0.0217	0.2606	0.3099
Plasmodium falciparum	SUMO-activating enzyme subunit 2	0.0037	0.0367	0.5394
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0049	0.0522	0.1225
Brugia malayi	AMP-binding enzyme family protein	0.0074	0.0833	0.2465
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0027	0.0251	0.0284
Brugia malayi	Ubiquitin-like protein SMT3	0.0036	0.0352	0.0988
Mycobacterium ulcerans	glutaminase	0.0271	0.3283	1
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0027	0.0251	0.0678
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0049	0.0522	0.1225
Brugia malayi	hypothetical protein	0.0012	0.0065	0.0104
Echinococcus multilocularis	SUMO activating enzyme subunit 2	0.0037	0.0367	0.0359
Echinococcus multilocularis	Small ubiquitin modifier 2	0.0036	0.0352	0.0344
Brugia malayi	AMP-binding enzyme family protein	0.0022	0.0181	0.0461
Toxoplasma gondii	propionate-CoA ligase	0.0022	0.0181	0.1611
Leishmania major	4-coumarate:coa ligase-like protein	0.0074	0.0833	0.1953
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0251	0.0674
Mycobacterium tuberculosis	P-hydroxybenzoyl-AMP ligase FadD22	0.0022	0.0181	0.0183
Entamoeba histolytica	protein tyrosine phosphatase, putative	0.0027	0.0251	0.0228
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.0067	0.0741	0.0825
Brugia malayi	Protein-tyrosine phosphatase	0.0027	0.0251	0.0678
Brugia malayi	hypothetical protein	0.0027	0.0251	0.0678
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0027	0.0251	0.0284
Entamoeba histolytica	dual specificity protein phosphatase, putative	0.0671	0.8265	1
Mycobacterium ulcerans	peptide synthetase Nrp (peptide synthase)	0.0022	0.0181	0.0037
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0833	0.2461
Trichomonas vaginalis	nuclear lim interactor-interacting factor, putative	0.0014	0.0089	0.0029
Onchocerca volvulus		0.0027	0.0251	0.0735
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0251	0.0674
Trypanosoma cruzi	hypothetical protein, conserved	0.0067	0.0741	0.1738
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0087	0.0166
Trichomonas vaginalis	nuclear lim interactor-interacting factor, putative	0.0014	0.0089	0.0029
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0599	0.1744
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0027	0.0251	0.0243
Onchocerca volvulus		0.0022	0.0181	0.0457
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.035	0.4263	1
Mycobacterium tuberculosis	Peptide synthetase MbtF (peptide synthase)	0.0022	0.0181	0.0183
Loa Loa (eye worm)	glutaminase 2	0.0271	0.3283	1
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0027	0.0251	0.0243
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0027	0.0251	0.0284
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0251	0.0674
Mycobacterium ulcerans	acyl-CoA synthetase	0.0022	0.0181	0.0037
Onchocerca volvulus		0.0027	0.0251	0.0735
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0027	0.0251	0.0674
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0027	0.0251	0.0439
Trichomonas vaginalis	nuclear lim interactor-interacting factor, putative	0.0014	0.0089	0.0029

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 625630