Detailed information for compound 647139

Basic information

Technical information
  • TDR Targets ID: 647139
  • Name: methyl 4-[3-[(Z)-2-cyano-3-[(3-ethoxyphenyl)a mino]-3-oxoprop-1-enyl]-2,5-dimethylpyrrol-1- yl]benzoate
  • MW: 443.494 | Formula: C26H25N3O4
  • H donors: 1 H acceptors: 3 LogP: 5.05 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOc1cccc(c1)NC(=O)/C(=C/c1cc(n(c1C)c1ccc(cc1)C(=O)OC)C)/C#N
  • InChi: 1S/C26H25N3O4/c1-5-33-24-8-6-7-22(15-24)28-25(30)21(16-27)14-20-13-17(2)29(18(20)3)23-11-9-19(10-12-23)26(31)32-4/h6-15H,5H2,1-4H3,(H,28,30)/b21-14-
  • InChiKey: SISRDZJUGJTWTP-STZFKDTASA-N  


Substructure search Similarity search

Network

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Synonyms

  • methyl 4-[3-[(Z)-2-cyano-3-[(3-ethoxyphenyl)amino]-3-oxo-prop-1-enyl]-2,5-dimethyl-pyrrol-1-yl]benzoate
  • 4-[3-[(Z)-2-cyano-3-[(3-ethoxyphenyl)amino]-3-oxoprop-1-enyl]-2,5-dimethyl-1-pyrrolyl]benzoic acid methyl ester
  • 4-[3-[(Z)-2-cyano-3-[(3-ethoxyphenyl)amino]-3-keto-prop-1-enyl]-2,5-dimethyl-pyrrol-1-yl]benzoic acid methyl ester
  • STK186481

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) cysteine protease 0.0033 0.0018 0.0107
Trypanosoma cruzi cysteine peptidase, putative 0.0017 0.0001 0.0115
Leishmania major hypothetical protein, conserved 0.0074 0.0062 0.2797
Loa Loa (eye worm) hypothetical protein 0.0055 0.0041 0.0254
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0252 0.0248 0.0248
Echinococcus multilocularis beta LACTamase domain containing family member 0.0074 0.0062 0.0062
Toxoplasma gondii thioredoxin reductase 0.0046 0.0031 0.1268
Loa Loa (eye worm) hypothetical protein 0.0066 0.0053 0.0329
Echinococcus granulosus beta LACTamase domain containing family member 0.0074 0.0062 0.0062
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0127 0.0116 1
Mycobacterium tuberculosis Probable hydrolase 0.0074 0.0062 0.0215
Leishmania major cathepsin L-like protease 0.0033 0.0018 0.083
Loa Loa (eye worm) hypothetical protein 0.0026 0.0011 0.0058
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0018 0.0227
Toxoplasma gondii cathepsin CPL 0.0033 0.0018 0.0738
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0018 0.0227
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0104 0.0093 0.0325
Echinococcus multilocularis expressed protein 0.0018 0.0002 0.0002
Brugia malayi Probable ClpP-like protease 0.0252 0.0248 0.1588
Entamoeba histolytica hypothetical protein 0.0386 0.0389 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0127 0.0116 1
Echinococcus granulosus expressed conserved protein 0.0179 0.0171 0.0171
Echinococcus granulosus tumor protein p63 0.2505 0.2614 0.2614
Brugia malayi Pre-SET motif family protein 0.0687 0.0705 0.4518
Loa Loa (eye worm) hypothetical protein 0.0168 0.016 0.1018
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0165 0.0157 0.054
Brugia malayi beta-lactamase family protein 0.0074 0.0062 0.0395
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0002 0.0005
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0018 0.0002 0.1922
Brugia malayi Papain family cysteine protease containing protein 0.0017 0.0001 0.0009
Brugia malayi beta-lactamase family protein 0.0074 0.0062 0.0395
Schistosoma mansoni hypothetical protein 0.0079 0.0066 0.0066
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0028 0.0013 0.1099
Brugia malayi AMP-binding enzyme family protein 0.0225 0.022 0.1411
Plasmodium vivax flap endonuclease 1, putative 0.0028 0.0013 0.0517
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0225 0.022 0.077
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0066 0.0053 0.0185
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0252 0.0248 1
Loa Loa (eye worm) hypothetical protein 0.0099 0.0087 0.0546
Mycobacterium ulcerans acyl-CoA synthetase 0.0225 0.022 0.077
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0002 0.0031
Loa Loa (eye worm) hypothetical protein 0.0074 0.0062 0.0384
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0002 0.0002
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0066 0.0053 0.0185
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.0062 0.5287
Loa Loa (eye worm) hypothetical protein 0.0225 0.022 0.1402
Mycobacterium tuberculosis Probable lipase LipD 0.0074 0.0062 0.0215
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0033 0.0018 0.0227
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0001 0.0017
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0386 0.0389 0.0389
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0087 0.0074 0.3004
Plasmodium falciparum acyl-CoA synthetase 0.0168 0.016 0.6473
Brugia malayi latrophilin 2 splice variant baaae 0.0038 0.0023 0.0147
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0074 0.0062 0.0395
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0066 0.0053 0.0329
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0066 0.0053 0.0185
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0018 0.0227
Trichomonas vaginalis ferritin, putative 0.0018 0.0002 0.0027
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0074 0.0062 0.0062
Brugia malayi Cathepsin L-like precursor 0.0033 0.0018 0.0117
Trichomonas vaginalis antibiotic synthetase, putative 0.0066 0.0053 0.0657
Brugia malayi CHE-14 protein 0.0082 0.0069 0.0444
Schistosoma mansoni apoferritin-2 0.0018 0.0002 0.0002
Echinococcus granulosus GPCR family 2 0.0017 0.0002 0.0002
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0066 0.0053 0.0185
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0017 0.0002 0.0002
Schistosoma mansoni intermediate filament proteins 0.0026 0.0011 0.0011
Mycobacterium ulcerans hypothetical protein 0.0074 0.0062 0.0215
Leishmania major cathepsin L-like protease 0.0127 0.0116 0.529
Plasmodium vivax acetyl-CoA synthetase, putative 0.0066 0.0053 0.2135
Schistosoma mansoni ferritin light chain 0.0018 0.0002 0.0002
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0066 0.0053 0.0177
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0168 0.016 0.056
Schistosoma mansoni cathepsin F (C01 family) 0.0033 0.0018 0.0018
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0066 0.0053 0.0185
Echinococcus multilocularis tumor protein p63 0.2505 0.2614 0.2614
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0252 0.0248 0.0866
Schistosoma mansoni hypothetical protein 0.0017 0.0002 0.0002
Onchocerca volvulus 0.0033 0.0018 0.0145
Entamoeba histolytica hypothetical protein 0.0386 0.0389 1
Trypanosoma cruzi major cysteine proteinase, putative 0.01 0.0088 0.7554
Plasmodium vivax thioredoxin reductase, putative 0.0046 0.0031 0.1268
Schistosoma mansoni hypothetical protein 0.0017 0.0002 0.0002
Brugia malayi Cathepsin L-like precursor 0.0033 0.0018 0.0117
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0062 0.0765
Mycobacterium tuberculosis Probable reductase 0.0104 0.0093 0.0325
Echinococcus granulosus ferritin 0.0018 0.0002 0.0002
Mycobacterium ulcerans acyl-CoA synthetase 0.0066 0.0053 0.0185
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0127 0.0116 1
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0074 0.0062 0.0384
Brugia malayi Papain family cysteine protease containing protein 0.0017 0.0001 0.0009
Onchocerca volvulus 0.0033 0.0018 0.0145
Mycobacterium tuberculosis Probable esterase LipL 0.0074 0.0062 0.0215
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0066 0.0053 0.0185
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0066 0.0053 0.0185
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0066 0.0053 0.454
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0104 0.0093 0.0325
Schistosoma mansoni hypothetical protein 0.0386 0.0389 0.0389
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0017 0.0002 0.0002
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0159 0.0151 0.0527
Toxoplasma gondii propionate-CoA ligase 0.0066 0.0053 0.2135
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0127 0.0116 1
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0066 0.0053 0.0185
Onchocerca volvulus 0.0033 0.0018 0.0145
Plasmodium vivax hypothetical protein, conserved 0.0074 0.0062 0.2487
Onchocerca volvulus 0.0066 0.0053 0.0578
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0066 0.0053 0.0185
Echinococcus multilocularis cathepsin L 0.0017 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.01 0.0089 0.0558
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0033 0.0018 0.0227
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0099 0.0087 0.0087
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0066 0.0053 0.0329
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0018 0.0227
Echinococcus granulosus intermediate filament protein 0.0026 0.0011 0.0011
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0104 0.0093 0.0325
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0127 0.0116 1
Mycobacterium tuberculosis Conserved protein 0.0074 0.0062 0.0215
Entamoeba histolytica Flap nuclease, putative 0.0028 0.0013 0.0296
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.0062 0.5287
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0001 0.0017
Entamoeba histolytica acyl-coA synthetase, putative 0.0225 0.022 0.5644
Schistosoma mansoni microtubule-associated protein tau 0.9538 1 1
Trypanosoma brucei hypothetical protein, conserved 0.0074 0.0062 0.5287
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0082 0.0069 0.0434
Loa Loa (eye worm) hypothetical protein 0.0252 0.0248 0.1578
Plasmodium falciparum flap endonuclease 1 0.0028 0.0013 0.0517
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0062 0.0765
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0011 0.0058
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0018 0.0227
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0252 0.0248 1
Brugia malayi Cathepsin L-like precursor 0.0033 0.0018 0.0117
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0033 0.0018 0.0227
Echinococcus multilocularis ferritin 0.0018 0.0002 0.0002
Plasmodium falciparum cysteine proteinase falcipain 3 0.0033 0.0018 0.0738
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0168 0.016 0.6473
Trichomonas vaginalis esterase, putative 0.0074 0.0062 0.0765
Loa Loa (eye worm) hypothetical protein 0.0026 0.001 0.0055
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0002 0.0031
Echinococcus granulosus expressed protein 0.0018 0.0002 0.0002
Giardia lamblia Flap structure-specific endonuclease 0.0028 0.0013 1
Leishmania major cathepsin L-like protease 0.0033 0.0018 0.083
Loa Loa (eye worm) hypothetical protein 0.0225 0.022 0.1402
Schistosoma mansoni ferritin 0.0018 0.0002 0.0002
Trypanosoma cruzi cysteine peptidase, putative 0.0127 0.0116 1
Loa Loa (eye worm) hypothetical protein 0.0168 0.016 0.1018
Echinococcus granulosus histone lysine methyltransferase setb 0.0099 0.0087 0.0087
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0168 0.016 0.056
Schistosoma mansoni hypothetical protein 0.0017 0.0002 0.0002
Mycobacterium tuberculosis Probable oxidoreductase 0.0116 0.0105 0.0368
Plasmodium vivax vivapain-1 0.0017 0.0001 0.0054
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0017 0.0001 0.0001
Mycobacterium ulcerans acyl-CoA synthetase 0.0225 0.022 0.077
Loa Loa (eye worm) beta-lactamase 0.0074 0.0062 0.0384
Echinococcus multilocularis cysteine protease 0.0033 0.0018 0.0018
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.0007 0.0084
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0252 0.0248 1
Onchocerca volvulus 0.0033 0.0018 0.0145
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.0007 0.0084
Echinococcus granulosus survival motor neuron protein 1 0.1501 0.1559 0.1559
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0306 0.0305 0.1955
Echinococcus multilocularis Niemann Pick C1 protein 0.0273 0.027 0.027
Mycobacterium ulcerans acyl-CoA synthetase 0.0066 0.0053 0.0185
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0033 0.0018 0.0227
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0252 0.0248 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0066 0.0053 0.0185
Brugia malayi Thioredoxin reductase 0.0046 0.0031 0.0201
Brugia malayi Flap endonuclease-1 0.0028 0.0013 0.0082
Mycobacterium ulcerans acyl-CoA synthetase 0.0066 0.0053 0.0185
Onchocerca volvulus 0.0074 0.0062 0.0687
Mycobacterium leprae Probable transcriptional regulatory repressor protein (TetR-family) EthR 0.2739 0.286 1
Onchocerca volvulus 0.0306 0.0305 0.3738
Brugia malayi Cathepsin L-like precursor 0.0033 0.0018 0.0117
Echinococcus granulosus cathepsin l1 0.0033 0.0018 0.0018
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0066 0.0053 0.454
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0033 0.0018 0.0227
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0225 0.022 0.077
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0066 0.0053 0.0053
Mycobacterium ulcerans acyl-CoA synthetase 0.0066 0.0053 0.0185
Loa Loa (eye worm) hypothetical protein 0.0022 0.0007 0.0032
Loa Loa (eye worm) hypothetical protein 0.0168 0.016 0.1018
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0017 0.0002 0.0002
Schistosoma mansoni ferritin 0.0018 0.0002 0.0002
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0017 0.0002 0.0011
Onchocerca volvulus 0.0033 0.0018 0.0145
Toxoplasma gondii ABC1 family protein 0.0074 0.0062 0.2487
Onchocerca volvulus 0.0066 0.0053 0.0578
Echinococcus granulosus cathepsin L cysteine proteinase 0.0033 0.0018 0.0018
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0057 0.0043 0.0151
Loa Loa (eye worm) hypothetical protein 0.0168 0.016 0.1018
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0066 0.0053 0.0185
Echinococcus multilocularis lamin dm0 0.0026 0.0011 0.0011
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0127 0.0116 1
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0104 0.0093 0.0325
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0159 0.0151 0.0527
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0002 0.0099
Entamoeba histolytica acyl-CoA synthetase, putative 0.0225 0.022 0.5644
Loa Loa (eye worm) glutathione reductase 0.0046 0.0031 0.0191
Echinococcus granulosus Protein patched homolog 1 0.0082 0.0069 0.0069
Onchocerca volvulus Cathepsin L homolog 0.0033 0.0018 0.0145
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0018 0.0227
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0018 0.0227
Plasmodium vivax vivapain-3 0.0017 0.0001 0.0054
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0687 0.0705 0.4512
Leishmania major cathepsin L-like protease 0.0127 0.0116 0.529
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0127 0.0116 1
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0225 0.022 0.0763
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0017 0.0001 0.0115
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0225 0.022 0.077
Onchocerca volvulus 0.0074 0.0062 0.0687
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0018 0.0227
Mycobacterium leprae POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) 0.0066 0.0053 0.0177
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0099 0.0087 0.0087
Loa Loa (eye worm) fibroinase 0.0033 0.0018 0.0107
Onchocerca volvulus 0.0782 0.0804 1
Mycobacterium ulcerans bacterioferritin BfrB 0.0018 0.0002 0.0008
Echinococcus granulosus cathepsin L 0.0017 0.0001 0.0001
Brugia malayi AMP-binding enzyme family protein 0.0066 0.0053 0.0339
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0252 0.0248 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0159 0.0151 0.0527
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0033 0.0018 0.0107
Mycobacterium ulcerans transcriptional regulator 0.2739 0.286 1
Echinococcus granulosus cathepsin l cysteine peptidase 0.0033 0.0018 0.0018
Echinococcus granulosus lamin dm0 0.0026 0.0011 0.0011
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0066 0.0053 0.454
Loa Loa (eye worm) hypothetical protein 0.0168 0.016 0.1018
Echinococcus multilocularis lamin 0.0026 0.0011 0.0011
Echinococcus granulosus thioredoxin glutathione reductase 0.0046 0.0031 0.0031
Brugia malayi Cathepsin L-like precursor 0.0022 0.0007 0.0043
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0066 0.0053 0.454
Loa Loa (eye worm) hypothetical protein 0.1501 0.1559 1
Loa Loa (eye worm) hypothetical protein 0.0066 0.0053 0.0329
Loa Loa (eye worm) hypothetical protein 0.0074 0.0062 0.0384
Leishmania major cathepsin L-like protease 0.0033 0.0018 0.083
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0074 0.0062 0.0215
Brugia malayi Calcitonin receptor-like protein seb-1 0.0055 0.0041 0.0265
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0066 0.0053 0.0185
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0017 0.0001 0.0001
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0055 0.0041 0.0254
Onchocerca volvulus 0.0066 0.0053 0.0578
Brugia malayi AMP-binding enzyme family protein 0.0225 0.022 0.1411
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0074 0.0062 0.0215
Mycobacterium leprae conserved hypothetical protein 0.0074 0.0062 0.0208
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0017 0.0002 0.0002
Echinococcus granulosus cathepsin l1 0.0022 0.0007 0.0007
Onchocerca volvulus 0.0225 0.022 0.2675
Echinococcus multilocularis microtubule associated protein 2 0.9538 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0018 0.0227
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0252 0.0248 1
Schistosoma mansoni acetyl-CoA synthetase 0.0066 0.0053 0.0053
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0099 0.0087 0.0087
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0066 0.0053 0.0185
Brugia malayi AMP-binding enzyme family protein 0.0066 0.0053 0.0339
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0225 0.022 0.077
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0033 0.0018 0.0018
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0018 0.0227
Trichomonas vaginalis penicillin-binding protein, putative 0.0074 0.0062 0.0765
Schistosoma mansoni hypothetical protein 0.0017 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0074 0.0062 0.0384
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0002 0.0112
Loa Loa (eye worm) hypothetical protein 0.0082 0.0069 0.0434
Brugia malayi Cathepsin L-like precursor 0.0033 0.0018 0.0117
Loa Loa (eye worm) hypothetical protein 0.0074 0.0062 0.0384
Plasmodium vivax acyl-CoA synthetase, putative 0.0168 0.016 0.6473
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0018 0.0002 0.0029
Echinococcus granulosus lamin 0.0026 0.0011 0.0011
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0099 0.0087 0.0087
Leishmania major 4-coumarate:coa ligase-like protein 0.0225 0.022 1
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0033 0.0018 0.0738
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0252 0.0248 0.0859
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0066 0.0053 0.0053
Echinococcus multilocularis protein dispatched 1 0.0093 0.0081 0.0081
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0099 0.0087 0.3506
Loa Loa (eye worm) hypothetical protein 0.0367 0.0368 0.2354
Schistosoma mansoni ap endonuclease 0.0018 0.0002 0.0002
Onchocerca volvulus Cathepsin F homolog 0.0033 0.0018 0.0145
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0252 0.0248 1
Mycobacterium ulcerans acetyl-CoA synthetase 0.0066 0.0053 0.0185
Wolbachia endosymbiont of Brugia malayi bacterioferritin/cytochrome b1 0.0018 0.0002 0.0087
Trypanosoma cruzi cysteine proteinase, putative 0.0017 0.0001 0.0115
Loa Loa (eye worm) flap endonuclease-1 0.0028 0.0013 0.0071
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0002 0.0002
Mycobacterium ulcerans acyl-CoA synthetase 0.0066 0.0053 0.0185
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0386 0.0389 0.0389
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0066 0.0053 0.454
Brugia malayi hypothetical protein 0.0386 0.0389 0.2494
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0066 0.0053 0.0185
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0066 0.0053 0.0185
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0225 0.022 0.0763
Echinococcus multilocularis GPCR, family 2 0.0017 0.0002 0.0002
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0011 0.0058
Treponema pallidum exodeoxyribonuclease (exoA) 0.0018 0.0002 0.0099
Brugia malayi Pre-SET motif family protein 0.0099 0.0087 0.0557
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0095 0.0083 0.0083
Entamoeba histolytica acyl-CoA synthetase, putative 0.0225 0.022 0.5644
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0018 0.0002 0.0009
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0194 0.0187 0.0187
Trichomonas vaginalis set domain proteins, putative 0.0782 0.0804 1
Toxoplasma gondii hypothetical protein 0.0087 0.0074 0.3004
Echinococcus granulosus cysteine protease 0.0017 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0074 0.0062 0.0384
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0066 0.0053 0.0185
Brugia malayi Latrophilin receptor protein 2 0.0017 0.0002 0.0011
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0028 0.0013 0.1099
Loa Loa (eye worm) ctsf protein 0.0033 0.0018 0.0107
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0018 0.0227
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0033 0.0018 0.0227
Mycobacterium ulcerans acyl-CoA synthetase 0.0066 0.0053 0.0185
Leishmania major cathepsin L-like protease 0.0033 0.0018 0.083
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0074 0.0062 0.0215
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0087 0.0074 0.3004
Loa Loa (eye worm) hypothetical protein 0.0038 0.0023 0.0137
Schistosoma mansoni hypothetical protein 0.0038 0.0023 0.0023
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0.0002 0.0009
Schistosoma mansoni peptidase Clp (S14 family) 0.0252 0.0248 0.0248
Entamoeba histolytica cysteine proteinase, putative 0.0033 0.0018 0.0437
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0476 0.0483 0.1689
Echinococcus granulosus peptidase Clp S14 family 0.0165 0.0157 0.0157
Plasmodium vivax glutathione reductase, putative 0.0046 0.0031 0.1268
Leishmania major 4-coumarate:coa ligase-like protein 0.0225 0.022 1
Entamoeba histolytica cysteine proteinase, putative 0.0033 0.0018 0.0437
Plasmodium vivax unspecified product 0.0017 0.0001 0.0054
Brugia malayi Cathepsin L-like precursor 0.0033 0.0018 0.0117
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0066 0.0053 0.2135
Entamoeba histolytica hypothetical protein 0.0386 0.0389 1
Mycobacterium tuberculosis Probable lipase LipE 0.0074 0.0062 0.0215
Plasmodium vivax SET domain protein, putative 0.0099 0.0087 0.3506
Loa Loa (eye worm) hypothetical protein 0.0074 0.0062 0.0384
Treponema pallidum bacterioferrin (TpF1) 0.0018 0.0002 0.0087
Mycobacterium leprae Probable lipase LipE 0.0074 0.0062 0.0208
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0066 0.0053 0.2402
Schistosoma mansoni transcription factor LCR-F1 0.0386 0.0389 0.0389
Leishmania major cathepsin L-like protease 0.0127 0.0116 0.529
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0127 0.0116 1
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0225 0.022 0.077
Schistosoma mansoni apoferritin-2 0.0018 0.0002 0.0002
Schistosoma mansoni flap endonuclease-1 0.0025 0.001 0.001
Trypanosoma cruzi cysteine protease, putative 0.0017 0.0001 0.0115
Toxoplasma gondii exonuclease III APE 0.0018 0.0002 0.0099
Schistosoma mansoni survival motor neuron protein 0.0306 0.0305 0.0305
Schistosoma mansoni cathepsin F (C01 family) 0.0022 0.0007 0.0007
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0087 0.0074 0.3004
Mycobacterium ulcerans acyl-CoA synthetase 0.0066 0.0053 0.0185
Entamoeba histolytica cysteine protease, putative 0.0033 0.0018 0.0437
Trypanosoma cruzi cysteine peptidase, putative 0.0127 0.0116 1
Onchocerca volvulus Cathepsin L homolog 0.0033 0.0018 0.0145
Mycobacterium ulcerans bacterioferritin BfrA 0.0018 0.0002 0.0008
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0225 0.022 0.077
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0033 0.0018 0.0738
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0033 0.0018 0.0227
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0104 0.0093 0.0318
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1571 0.1633 0.1633
Mycobacterium tuberculosis Probable dehydrogenase 0.0104 0.0093 0.0325
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0002 0.0016
Echinococcus multilocularis musashi 0.0026 0.0011 0.0011
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0017 0.0001 0.0001
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0002 0.0211
Schistosoma mansoni ferritin 0.0018 0.0002 0.0002
Mycobacterium ulcerans TetR family transcriptional regulator 0.2739 0.286 1
Leishmania major acetyl-CoA synthetase, putative 0.0066 0.0053 0.2402
Onchocerca volvulus 0.0066 0.0053 0.0578
Mycobacterium ulcerans AcrR family transcriptional regulator 0.2739 0.286 1
Leishmania major cathepsin L-like protease 0.0033 0.0018 0.083
Brugia malayi Papain family cysteine protease containing protein 0.0033 0.0018 0.0117
Brugia malayi glutathione reductase 0.0046 0.0031 0.0201
Trichomonas vaginalis conserved hypothetical protein 0.0082 0.0069 0.0861
Loa Loa (eye worm) hypothetical protein 0.0022 0.0007 0.0032
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0018 0.0227
Onchocerca volvulus 0.0026 0.0011 0.005
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0116 0.0105 0.9008
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0165 0.0157 0.0547
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0074 0.0062 0.0062
Onchocerca volvulus 0.0033 0.0018 0.0145
Schistosoma mansoni cellular tumor antigen P53 0.0367 0.0368 0.0368
Onchocerca volvulus 0.0026 0.0011 0.005
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0033 0.0018 0.0227
Schistosoma mansoni hypothetical protein 0.0079 0.0066 0.0066
Schistosoma mansoni hypothetical protein 0.0079 0.0066 0.0066
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0033 0.0018 0.0227
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0055 0.0041 0.0265
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0087 0.0074 0.0253
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0002 0.0211
Trypanosoma cruzi cysteine peptidase, putative 0.0033 0.0018 0.157
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0033 0.0018 0.0018
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0028 0.0013 0.0517
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0028 0.0013 0.0582
Schistosoma mansoni hypothetical protein 0.0079 0.0066 0.0066
Schistosoma mansoni ferritin light chain 0.0018 0.0002 0.0002
Echinococcus granulosus flap endonuclease 1 0.0028 0.0013 0.0013
Brugia malayi AMP-binding enzyme family protein 0.0225 0.022 0.1411
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0165 0.0157 0.0547
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0099 0.0087 0.0087
Mycobacterium ulcerans acyl-CoA synthetase 0.0225 0.022 0.077
Brugia malayi Cathepsin L-like precursor 0.0022 0.0007 0.0043
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0066 0.0053 0.0185
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0062 0.0765
Loa Loa (eye worm) hypothetical protein 0.0022 0.0007 0.0032
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0033 0.0018 0.0107
Brugia malayi hypothetical protein 0.1501 0.1559 1
Loa Loa (eye worm) thioredoxin reductase 0.0046 0.0031 0.0191
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0099 0.0087 0.0087
Echinococcus granulosus sterol regulatory element binding protein 0.0082 0.0069 0.0069
Schistosoma mansoni patched 1 0.0082 0.0069 0.0069
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0011 0.0069
Leishmania major acetyl-CoA synthetase, putative 0.0066 0.0053 0.2402
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0017 0.0001 0.0115
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0018 0.0002 0.0008
Brugia malayi Cathepsin L-like cysteine proteinase 0.0022 0.0007 0.0043
Onchocerca volvulus 0.0367 0.0368 0.4535
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0018 0.0227
Mycobacterium ulcerans beta-lactamase 0.0074 0.0062 0.0215
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0033 0.0018 0.0227
Brugia malayi AMP-binding enzyme family protein 0.0066 0.0053 0.0339
Mycobacterium leprae POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0066 0.0053 0.0177
Schistosoma mansoni lamin 0.0026 0.0011 0.0011
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0127 0.0116 1
Mycobacterium tuberculosis Transcriptional regulatory repressor protein (TetR-family) EthR 0.2739 0.286 1
Loa Loa (eye worm) hypothetical protein 0.0191 0.0184 0.1168
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0018 0.0227
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0018 0.0002 0.0008
Trypanosoma cruzi cysteine proteinase, putative 0.0017 0.0001 0.0115
Mycobacterium tuberculosis Conserved protein 0.0074 0.0062 0.0215
Echinococcus multilocularis cathepsin L cysteine protease 0.0033 0.0018 0.0018
Brugia malayi cathepsin L-like precursor 0.0022 0.0007 0.0043
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0116 0.0105 0.0368
Brugia malayi AMP-binding enzyme family protein 0.0066 0.0053 0.0339
Trypanosoma cruzi cysteine peptidase, putative 0.0127 0.0116 1
Echinococcus multilocularis cysteine protease 0.0033 0.0018 0.0018
Plasmodium falciparum cysteine proteinase falcipain 1 0.0017 0.0001 0.0054
Schistosoma mansoni lamin 0.0026 0.0011 0.0011
Entamoeba histolytica cysteine proteinase, putative 0.0022 0.0007 0.0139
Brugia malayi Niemann-Pick C1 protein precursor 0.0191 0.0184 0.1177
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0074 0.0062 0.0215
Schistosoma mansoni ap endonuclease 0.0018 0.0002 0.0002
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0066 0.0053 0.2135
Schistosoma mansoni cathepsin F (C01 family) 0.0033 0.0018 0.0018
Schistosoma mansoni ferritin 0.0018 0.0002 0.0002
Mycobacterium ulcerans lipase LipD 0.0074 0.0062 0.0215
Trichomonas vaginalis penicillin-binding protein, putative 0.0074 0.0062 0.0765
Trichomonas vaginalis antibiotic synthetase, putative 0.0066 0.0053 0.0657
Onchocerca volvulus 0.0033 0.0018 0.0145
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0002 0.0211
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0066 0.0053 0.2135
Echinococcus multilocularis sterol regulatory element binding protein 0.0082 0.0069 0.0069
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0159 0.0151 0.0527
Mycobacterium ulcerans esterase/lipase LipP 0.0074 0.0062 0.0215
Leishmania major trypanothione reductase 0.0046 0.0031 0.1427
Echinococcus multilocularis protein patched 0.0082 0.0069 0.0069
Onchocerca volvulus 0.0074 0.0062 0.0687
Plasmodium falciparum glutathione reductase 0.0046 0.0031 0.1268
Loa Loa (eye worm) oxidoreductase 0.0066 0.0053 0.0329
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0066 0.0053 0.1329
Plasmodium vivax vivapain-2 0.0033 0.0018 0.0738
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0066 0.0053 0.0185
Echinococcus multilocularis thioredoxin glutathione reductase 0.0046 0.0031 0.0031
Plasmodium falciparum thioredoxin reductase 0.0046 0.0031 0.1268
Echinococcus multilocularis Niemann Pick C1 protein 0.0191 0.0184 0.0184
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0252 0.0248 0.0866
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0191 0.0184 0.4702
Trypanosoma brucei trypanothione reductase 0.0046 0.0031 0.2697
Echinococcus granulosus cathepsin L cysteine protease 0.0017 0.0001 0.0001
Echinococcus multilocularis flap endonuclease 1 0.0028 0.0013 0.0013
Echinococcus multilocularis cathepsin L cysteine protease 0.0033 0.0018 0.0018
Brugia malayi intermediate filament protein 0.0026 0.0011 0.0069
Mycobacterium tuberculosis Conserved protein 0.0074 0.0062 0.0215
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0033 0.0018 0.0227
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0127 0.0116 1
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0252 0.0248 0.0248
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0046 0.0031 0.011
Loa Loa (eye worm) hypothetical protein 0.0033 0.0018 0.0107
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0066 0.0053 0.0339
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0127 0.0116 1
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0002 0.0099
Brugia malayi beta-lactamase 0.0074 0.0062 0.0395
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0018 0.0002 0.0099
Onchocerca volvulus 0.0099 0.0087 0.1004
Echinococcus multilocularis expressed conserved protein 0.0179 0.0171 0.0171
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0066 0.0053 0.0185
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0066 0.0053 0.0339
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0116 0.0105 0.0368
Trichomonas vaginalis flap endonuclease-1, putative 0.0028 0.0013 0.0159
Echinococcus multilocularis survival motor neuron protein 1 0.1501 0.1559 0.1559
Schistosoma mansoni hypothetical protein 0.0306 0.0305 0.0305
Plasmodium vivax vivapain-2 0.0033 0.0018 0.0738
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0252 0.0248 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0017 0.0001 0.0115
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0066 0.0053 0.454
Leishmania major 4-coumarate:coa ligase-like protein 0.0225 0.022 1
Loa Loa (eye worm) hypothetical protein 0.0225 0.022 0.1402
Leishmania major cysteine peptidase A (CPA) 0.0033 0.0018 0.083
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0066 0.0053 0.0185
Trypanosoma cruzi cruzipain precursor, putative 0.0127 0.0116 1
Trypanosoma cruzi trypanothione reductase, putative 0.0046 0.0031 0.2697
Mycobacterium ulcerans hypothetical protein 0.0225 0.022 0.077
Echinococcus multilocularis peptidase Clp (S14 family) 0.0165 0.0157 0.0157
Echinococcus granulosus Niemann Pick C1 protein 0.0273 0.027 0.027
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0116 0.0105 0.0361
Entamoeba histolytica hypothetical protein 0.0386 0.0389 1
Echinococcus granulosus Niemann Pick C1 protein 0.0191 0.0184 0.0184

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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