Detailed information for compound 648159

Basic information

Technical information
  • TDR Targets ID: 648159
  • Name: 1-[4-(2-chloro-4-nitrophenyl)piperazin-1-yl]- 2-(4-methylphenoxy)ethanone
  • MW: 389.833 | Formula: C19H20ClN3O4
  • H donors: 0 H acceptors: 3 LogP: 3.84 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccc(cc1)OCC(=O)N1CCN(CC1)c1ccc(cc1Cl)[N+](=O)[O-]
  • InChi: 1S/C19H20ClN3O4/c1-14-2-5-16(6-3-14)27-13-19(24)22-10-8-21(9-11-22)18-7-4-15(23(25)26)12-17(18)20/h2-7,12H,8-11,13H2,1H3
  • InChiKey: OCNCSWGJETZWJE-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-[4-(2-chloro-4-nitro-phenyl)piperazin-1-yl]-2-(4-methylphenoxy)ethanone
  • 1-[4-(2-chloro-4-nitrophenyl)-1-piperazinyl]-2-(4-methylphenoxy)ethanone
  • STK248075
  • ZINC04457582
  • 1-[4-(2-Chloro-4-nitro-phenyl)-piperazin-1-yl]-2-p-tolyloxy-ethanone
  • BAS 01844982
  • Oprea1_783095
  • AK-778/13520035

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0011 0.0007 0.0007
Echinococcus granulosus inositol monophosphatase 1 0.0039 0.0209 0.0209
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0186 0.1264 0.1263
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0017 0.0049 0.0049
Schistosoma mansoni regulator of G protein signaling 0.002 0.0074 0.0074
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0047 0.0271 0.0271
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0074 0.0074
Toxoplasma gondii thioredoxin reductase 0.0046 0.0263 0.0436
Brugia malayi Thioredoxin reductase 0.0046 0.0263 0.0522
Echinococcus multilocularis cysteine protease 0.0018 0.0056 0.0056
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0017 0.0049 0.0048
Loa Loa (eye worm) hypothetical protein 0.0712 0.504 1
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0202 0.1178
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0065 0.0397 0.458
Echinococcus granulosus smad 0.0017 0.0049 0.0049
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.002 0.0077 0.0076
Brugia malayi Cathepsin L-like precursor 0.0018 0.0056 0.0111
Echinococcus multilocularis ecdysone induced protein 78C 0.002 0.0077 0.0077
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0047 0.0271 0.0271
Schistosoma mansoni endothelin-converting enzyme-related 0.0173 0.1175 0.1174
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0018 0.0056 0.0327
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.002 0.0077 0.0077
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0007 0.0014
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0146 0.0146
Brugia malayi nuclear hormone receptor 0.002 0.0077 0.0151
Echinococcus multilocularis neuropeptide receptor A26 0.0487 0.3424 0.3424
Schistosoma mansoni thyroid hormone receptor 0.002 0.0077 0.0076
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.0412 1
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.002 0.0074 0.0429
Loa Loa (eye worm) hypothetical protein 0.0018 0.0062 0.0123
Brugia malayi Cathepsin L-like precursor 0.0018 0.0056 0.0111
Entamoeba histolytica hypothetical protein 0.0038 0.0202 0.2156
Schistosoma mansoni nuclear hormone receptor 0.002 0.0077 0.0076
Entamoeba histolytica acyl-coA synthetase, putative 0.0025 0.0107 0.1138
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.002 0.0074 0.0147
Echinococcus multilocularis expressed protein 0.0391 0.2736 0.2736
Echinococcus multilocularis axis inhibition protein axin 0.002 0.0074 0.0074
Leishmania major cathepsin L-like protease 0.0018 0.0056 0.0142
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0159 0.0158
Loa Loa (eye worm) hypothetical protein 0.002 0.0077 0.0152
Brugia malayi CXXC zinc finger family protein 0.0028 0.013 0.0257
Schistosoma mansoni cpg binding protein 0.0029 0.0141 0.0141
Brugia malayi Nuclear hormone receptor family member nhr-3 0.002 0.0077 0.0151
Brugia malayi Steroid receptor seven-up type 2 0.002 0.0077 0.0151
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0056 0.0327
Brugia malayi Cathepsin L-like precursor 0.0018 0.0056 0.0111
Loa Loa (eye worm) hypothetical protein 0.0018 0.0062 0.0123
Echinococcus granulosus transcription factor Dp 1 0.0038 0.02 0.02
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0056 0.0327
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0056 0.0327
Echinococcus granulosus geminin 0.0512 0.3604 0.3604
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0077 0.0077
Trypanosoma cruzi cysteine peptidase, putative 0.0067 0.0412 1
Plasmodium vivax glutathione reductase, putative 0.0046 0.0263 1
Brugia malayi MH2 domain containing protein 0.0017 0.0049 0.0096
Brugia malayi hypothetical protein 0.0318 0.2213 0.4391
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0039 0.0209 0.2226
Plasmodium vivax thioredoxin reductase, putative 0.0046 0.0263 1
Leishmania major cathepsin L-like protease 0.0067 0.0412 0.4776
Echinococcus granulosus regulator of G protein signaling 7 0.002 0.0074 0.0074
Echinococcus granulosus neuropeptide receptor A26 0.0487 0.3424 0.3424
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0035 0.018 0.0269
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0056 0.0327
Brugia malayi Cathepsin L-like precursor 0.0018 0.0056 0.0111
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0107 0.0212
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0039 0.0209 0.0327
Echinococcus multilocularis inositol monophosphatase 1 0.0039 0.0209 0.0209
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0025 0.0107 0.0123
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0123 0.0813 0.1536
Loa Loa (eye worm) pigment dispersing factor receptor c 0.015 0.1007 0.1997
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0065 0.0397 0.0397
Echinococcus multilocularis axis inhibition protein axin 0.002 0.0074 0.0074
Loa Loa (eye worm) hypothetical protein 0.001 0 0.0001
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0077 0.0151
Brugia malayi latrophilin 2 splice variant baaae 0.0103 0.0666 0.1321
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0209 0.4461
Echinococcus granulosus beta-adrenergic receptor kinase 0.002 0.0074 0.0074
Loa Loa (eye worm) hypothetical protein 0.025 0.1722 0.3417
Loa Loa (eye worm) hypothetical protein 0.015 0.1007 0.1997
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.002 0.0077 0.0077
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0077 0.0077
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0229 0.1571 0.3117
Brugia malayi Smad1 0.0017 0.0049 0.0096
Schistosoma mansoni hypothetical protein 0.0186 0.1264 0.1263
Plasmodium vivax basic transcription factor 3b, putative 0.0038 0.0202 0.7195
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0229 0.1571 0.1571
Onchocerca volvulus Protein ultraspiracle homolog 0.002 0.0077 0.031
Toxoplasma gondii NAC domain-containing protein 0.0038 0.0202 0.0314
Schistosoma mansoni z-protein (S1r protein) 0.002 0.0074 0.0074
Schistosoma mansoni regulator of G protein signaling 0.002 0.0074 0.0074
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0077 0.0077
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.0412 1
Entamoeba histolytica hypothetical protein 0.002 0.0074 0.0786
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0056 0.0327
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0056 0.0327
Schistosoma mansoni inositol monophosphatase 0.0039 0.0209 0.0209
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.0159 0.0159
Plasmodium falciparum cysteine proteinase falcipain 3 0.0018 0.0056 0.05
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0229 0.1571 0.1571
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.002 0.0077 0.0076
Schistosoma mansoni coup transcription factor 0.002 0.0077 0.0076
Brugia malayi hypothetical protein 0.0011 0.0007 0.0014
Entamoeba histolytica cysteine protease, putative 0.0018 0.0056 0.0598
Schistosoma mansoni RAR-like nuclear receptor 0.002 0.0077 0.0076
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0056 0.0327
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0016 0.0045 0.009
Brugia malayi Cathepsin L-like precursor 0.0012 0.0015 0.0028
Loa Loa (eye worm) hypothetical protein 0.002 0.0074 0.0147
Loa Loa (eye worm) hypothetical protein 0.001 0 0.0001
Echinococcus granulosus cathepsin L cysteine proteinase 0.0018 0.0056 0.0056
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0011 0.0007 0.0015
Echinococcus multilocularis cathepsin L cysteine protease 0.0018 0.0056 0.0056
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0065 0.0397 0.0396
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0056 0.0327
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0397 0.9589
Plasmodium falciparum glutathione reductase 0.0046 0.0263 1
Trichomonas vaginalis glutathione reductase, putative 0.0016 0.0045 0.0263
Echinococcus granulosus ecdysone induced protein 78C 0.002 0.0077 0.0077
Loa Loa (eye worm) hypothetical protein 0.0011 0.0007 0.0015
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.0107 0.1138
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0649 0.4589 0.9096
Mycobacterium ulcerans aldehyde dehydrogenase 0.0123 0.0813 0.1536
Brugia malayi Nuclear hormone receptor family member nhr-31 0.002 0.0077 0.0151
Onchocerca volvulus 0.0018 0.0056 0.0228
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0074 0.0074
Echinococcus granulosus axis inhibition protein axin 0.002 0.0074 0.0074
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.002 0.0077 0.0077
Entamoeba histolytica hypothetical protein 0.0038 0.0202 0.2149
Plasmodium vivax vivapain-2 0.0018 0.0056 0.05
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0062 0.0034
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0107 0.0123
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0229 0.1571 0.1571
Loa Loa (eye worm) hypothetical protein 0.0021 0.0079 0.0156
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0229 0.1571 0.1571
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0025 0.0107 0.0123
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.0412 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0055 0.0019
Loa Loa (eye worm) hypothetical protein 0.002 0.0077 0.0152
Echinococcus multilocularis geminin 0.0512 0.3604 0.3604
Brugia malayi peptidase family M13 containing protein 0.0173 0.1175 0.233
Loa Loa (eye worm) hypothetical protein 0.002 0.0074 0.0147
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.002 0.0074 0.0147
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0123 0.0813 0.0813
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0056 0.0327
Echinococcus granulosus mothers against decapentaplegic 5 0.0017 0.0049 0.0049
Echinococcus multilocularis neuropeptide s receptor 0.0487 0.3424 0.3424
Loa Loa (eye worm) hypothetical protein 0.0318 0.2213 0.4391
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0065 0.0397 0.0787
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.0412 1
Schistosoma mansoni aldehyde dehydrogenase 0.0123 0.0813 0.0812
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0107 0.0212
Brugia malayi Cathepsin L-like cysteine proteinase 0.0012 0.0015 0.0028
Loa Loa (eye worm) hypothetical protein 0.0538 0.3795 0.753
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.0363 0.0362
Loa Loa (eye worm) transcription factor SMAD2 0.0243 0.1672 0.3317
Leishmania major basic transcription factor 3a, putative 0.0038 0.0202 0.2045
Echinococcus granulosus cathepsin l1 0.0018 0.0056 0.0056
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.002 0.0077 0.0077
Trypanosoma cruzi cysteine peptidase, putative 0.0067 0.0412 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.0412 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.014 0.0937 0.5463
Echinococcus multilocularis cathepsin L cysteine protease 0.0018 0.0056 0.0056
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0039 0.0209 1
Trypanosoma cruzi trypanothione reductase, putative 0.0046 0.0263 0.595
Entamoeba histolytica hypothetical protein 0.002 0.0074 0.0786
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.014 0.0937 0.5463
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0173 0.1175 0.1174
Schistosoma mansoni microtubule-associated protein tau 0.1402 1 1
Brugia malayi ecdysteroid receptor 0.002 0.0077 0.0151
Loa Loa (eye worm) hypothetical protein 0.0047 0.0271 0.0537
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0712 0.504 0.504
Echinococcus granulosus endothelin converting enzyme 1 0.0712 0.504 0.504
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.014 0.0937 0.5463
Brugia malayi nuclear receptor NHR-88 0.002 0.0077 0.0151
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.0412 1
Loa Loa (eye worm) thioredoxin reductase 0.0046 0.0263 0.0523
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0018 0.0056 0.0112
Echinococcus granulosus Polycystic kidney disease protein 0.0021 0.0079 0.0079
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0173 0.1175 0.1174
Onchocerca volvulus 0.0018 0.0056 0.0228
Brugia malayi MH1 domain containing protein 0.0017 0.0049 0.0096
Brugia malayi regulator of G-protein signaling rgs-7 0.002 0.0074 0.0146
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0047 0.0271 0.0271
Loa Loa (eye worm) G protein alpha subunit 3 0.001 0 0.0001
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0018 0.0056 0.0327
Loa Loa (eye worm) hypothetical protein 0.002 0.0077 0.0152
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0065 0.0397 0.0787
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0012 0.0015 0.0083
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0649 0.4589 0.9085
Brugia malayi MH1 domain containing protein 0.0017 0.0049 0.0096
Echinococcus multilocularis regulator of G protein signaling 7 0.002 0.0074 0.0074
Echinococcus multilocularis GPCR, family 2 0.0047 0.0271 0.0271
Echinococcus granulosus expressed protein 0.0391 0.2736 0.2736
Schistosoma mansoni hypothetical protein 0.0186 0.1264 0.1263
Schistosoma mansoni hypothetical protein 0.0047 0.0271 0.027
Schistosoma mansoni hypothetical protein 0.0047 0.0271 0.027
Schistosoma mansoni hypothetical protein 0.0512 0.3604 0.3604
Echinococcus granulosus retinoic acid receptor rxr beta a 0.002 0.0077 0.0077
Loa Loa (eye worm) ICD-1 protein 0.0038 0.0202 0.0401
Echinococcus granulosus lipoxygenase domain containing protein 0.0021 0.0079 0.0079
Onchocerca volvulus Bile acid receptor homolog 0.002 0.0077 0.031
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0061 0.037 0.8859
Loa Loa (eye worm) hypothetical protein 0.0712 0.504 1
Schistosoma mansoni inositol monophosphatase 0.0039 0.0209 0.0209
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0077 0.0151
Schistosoma mansoni aldehyde dehydrogenase 0.0123 0.0813 0.0812
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.002 0.0074 0.0074
Toxoplasma gondii cathepsin CPL 0.0018 0.0056 0.0022
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0074 0.0429
Onchocerca volvulus 0.0018 0.0056 0.0228
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.002 0.0077 0.0076
Onchocerca volvulus Cathepsin F homolog 0.0018 0.0056 0.0228
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0106 0.0691 0.1292
Echinococcus granulosus GPCR family 2 0.0047 0.0271 0.0271
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.002 0.0077 0.0152
Onchocerca volvulus 0.0021 0.0079 0.0319
Echinococcus granulosus cpg binding protein 0.0029 0.0141 0.0141
Trichomonas vaginalis set domain proteins, putative 0.0249 0.1715 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0123 0.0813 0.1536
Entamoeba histolytica transcription factor BTF3, putative 0.0038 0.0202 0.2156
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0077 0.0151
Schistosoma mansoni lipoxygenase 0.0087 0.0553 0.0553
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.002 0.0074 0.0074
Echinococcus multilocularis beta adrenergic receptor kinase 0.002 0.0074 0.0074
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0011 0.0007 0.0007
Schistosoma mansoni steroid hormone receptor ad4bp 0.002 0.0077 0.0076
Schistosoma mansoni cathepsin F (C01 family) 0.0012 0.0015 0.0014
Plasmodium falciparum thioredoxin reductase 0.0046 0.0263 1
Mycobacterium leprae probable zinc metalloprotease 0.0712 0.504 1
Trichomonas vaginalis mercuric reductase, putative 0.0016 0.0045 0.0263
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0056 0.0327
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0047 0.0271 0.0536
Loa Loa (eye worm) hypothetical protein 0.0032 0.0159 0.0315
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0056 0.0327
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.002 0.0077 0.0152
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0056 0.0327
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0012 0.0015 0.0029
Loa Loa (eye worm) hypothetical protein 0.0018 0.0062 0.0123
Schistosoma mansoni cathepsin F (C01 family) 0.0018 0.0056 0.0056
Entamoeba histolytica hypothetical protein 0.002 0.0074 0.0786
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0018 0.0056 0.0056
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0123 0.0813 1
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0106 0.0691 0.1292
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0359 0.2508 0.2508
Onchocerca volvulus 0.002 0.0077 0.031
Schistosoma mansoni transcription factor LCR-F1 0.0038 0.0202 0.0201
Echinococcus granulosus neuropeptide s receptor 0.0487 0.3424 0.3424
Leishmania major trypanothione reductase 0.0046 0.0263 0.2842
Echinococcus multilocularis microtubule associated protein 2 0.1402 1 1
Leishmania major cysteine peptidase A (CPA) 0.0018 0.0056 0.0142
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.002 0.0077 0.031
Echinococcus granulosus regulator of G protein signaling 3 0.002 0.0074 0.0074
Echinococcus granulosus thioredoxin glutathione reductase 0.0046 0.0263 0.0263
Giardia lamblia Fructose-bisphosphate aldolase 0.014 0.0937 1
Loa Loa (eye worm) hypothetical protein 0.0712 0.504 1
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0359 0.2508 0.2508
Leishmania major cathepsin L-like protease 0.0018 0.0056 0.0142
Loa Loa (eye worm) hypothetical protein 0.0018 0.0056 0.0112
Loa Loa (eye worm) MH2 domain-containing protein 0.0017 0.0049 0.0096
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0107 0.0123
Brugia malayi Pre-SET motif family protein 0.0032 0.0159 0.0314
Loa Loa (eye worm) hypothetical protein 0.0011 0.0007 0.0015
Echinococcus multilocularis cysteine protease 0.0018 0.0056 0.0056
Loa Loa (eye worm) hypothetical protein 0.0011 0.0007 0.0015
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.002 0.0077 0.0077
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0397 0.9589
Brugia malayi MH2 domain containing protein 0.0017 0.0049 0.0096
Schistosoma mansoni hypothetical protein 0.0047 0.0271 0.027
Brugia malayi hypothetical protein 0.0021 0.0079 0.0156
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0018 0.0062 1
Entamoeba histolytica hypothetical protein 0.0038 0.0202 0.2149
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.014 0.0937 0.5463
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0107 0.0802
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0074 0.0429
Loa Loa (eye worm) hypothetical protein 0.002 0.0077 0.0152
Loa Loa (eye worm) heterotrimeric G protein alpha subunit 0.001 0 0.0001
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.002 0.0077 0.0077
Toxoplasma gondii histone lysine methyltransferase SET1 0.0054 0.0317 0.0544
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.014 0.0937 0.5463
Leishmania major cathepsin L-like protease 0.0018 0.0056 0.0142
Plasmodium vivax vivapain-2 0.0018 0.0056 0.05
Plasmodium vivax acyl-CoA synthetase, putative 0.0018 0.0062 0.0768
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.0159 0.0227
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.002 0.0077 0.0152
Schistosoma mansoni smad1 5 8 and 0.0017 0.0049 0.0048
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0077 0.0151
Loa Loa (eye worm) glutathione reductase 0.0046 0.0263 0.0523
Brugia malayi hypothetical protein 0.025 0.1722 0.3416
Loa Loa (eye worm) MH1 domain-containing protein 0.0017 0.0049 0.0096
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0011 0.0007 0.0007
Echinococcus granulosus RUN 0.0021 0.0079 0.0079
Onchocerca volvulus Huntingtin homolog 0.025 0.1722 0.6995
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0074 0.0429
Onchocerca volvulus 0.0018 0.0056 0.0228
Schistosoma mansoni hypothetical protein 0.0047 0.0271 0.027
Brugia malayi Latrophilin receptor protein 2 0.0047 0.0271 0.0536
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0397 0.9589
Loa Loa (eye worm) hypothetical protein 0.002 0.0074 0.0147
Schistosoma mansoni Tr4/Tr2 (homologue) 0.002 0.0077 0.0076
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0056 0.0327
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0124 0.0821 0.0821
Onchocerca volvulus Huntingtin homolog 0.025 0.1722 0.6995
Schistosoma mansoni loxhd1 0.0021 0.0079 0.0078
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0074 0.0429
Echinococcus granulosus regulator of G protein signaling 7 0.002 0.0074 0.0074
Echinococcus multilocularis transcription factor btf3 0.0038 0.0202 0.0202
Onchocerca volvulus 0.0012 0.0015 0.0058
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0202 0.1178
Loa Loa (eye worm) hypothetical protein 0.0538 0.3795 0.753
Loa Loa (eye worm) peptidase family M13 containing protein 0.0526 0.3706 0.7354
Onchocerca volvulus 0.0025 0.0107 0.0433
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0107 0.0802
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0219 0.1499 0.2974
Onchocerca volvulus 0.0018 0.0056 0.0228
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0077 0.0077
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0056 0.0327
Schistosoma mansoni axis inhibition protein axin 0.002 0.0074 0.0074
Loa Loa (eye worm) RGS-3 protein 0.002 0.0074 0.0147
Plasmodium vivax SET domain protein, putative 0.0032 0.0159 0.5193
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0209 0.4461
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0118 0.0776 0.1356
Brugia malayi Nuclear hormone receptor family member nhr-14 0.002 0.0077 0.0151
Trypanosoma cruzi transcription factor btf3, putative 0.0038 0.0202 0.4281
Treponema pallidum fructose-bisphosphate aldolase 0.014 0.0937 1
Echinococcus multilocularis thyroid hormone receptor alpha 0.002 0.0077 0.0077
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0056 0.0327
Onchocerca volvulus 0.0021 0.0079 0.0319
Loa Loa (eye worm) hypothetical protein 0.001 0 0.0001
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0018 0.0062 0.0034
Loa Loa (eye worm) hypothetical protein 0.002 0.0074 0.0147
Brugia malayi steroid hormone receptor 0.002 0.0077 0.0151
Loa Loa (eye worm) hypothetical protein 0.0025 0.0107 0.0212
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0056 0.0327
Leishmania major cathepsin L-like protease 0.0067 0.0412 0.4776
Loa Loa (eye worm) hypothetical protein 0.0012 0.0015 0.0029
Entamoeba histolytica hypothetical protein 0.0038 0.0202 0.2149
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.0412 1
Brugia malayi Cathepsin L-like precursor 0.0018 0.0056 0.0111
Brugia malayi cathepsin L-like precursor 0.0012 0.0015 0.0028
Entamoeba histolytica cysteine proteinase, putative 0.0018 0.0056 0.0598
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0209 0.2131
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0074 0.0074
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0074 0.0429
Schistosoma mansoni rab6-interacting 0.0021 0.0079 0.0078
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.002 0.0074 0.0074
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-6 subunit 0.001 0 0.0001
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0209 0.4461
Brugia malayi Nuclear hormone receptor family member nhr-41 0.002 0.0077 0.0151
Loa Loa (eye worm) steroid hormone receptor 0.002 0.0077 0.0152
Loa Loa (eye worm) doublecortin family protein 0.0021 0.0079 0.0156
Mycobacterium ulcerans aldehyde dehydrogenase 0.0123 0.0813 0.1536
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0065 0.0397 0.4232
Loa Loa (eye worm) hypothetical protein 0.0526 0.3706 0.7354
Schistosoma mansoni smad1 5 8 and 0.0017 0.0049 0.0048
Echinococcus granulosus cathepsin l cysteine peptidase 0.0018 0.0056 0.0056
Loa Loa (eye worm) ctsf protein 0.0018 0.0056 0.0112
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0018 0.0056 0.05
Plasmodium falciparum LCCL domain-containing protein 0.0021 0.0079 0.153
Mycobacterium tuberculosis Probable zinc metalloprotease Zmp1 0.0712 0.504 1
Schistosoma mansoni Nep2 peptidase (M13 family) 0.0359 0.2508 0.2508
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.002 0.0074 0.0074
Leishmania major cathepsin L-like protease 0.0018 0.0056 0.0142
Schistosoma mansoni regulator of G protein signaling 0.002 0.0074 0.0074
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.002 0.0077 0.0077
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.002 0.0077 0.0152
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.014 0.0937 1
Loa Loa (eye worm) hypothetical protein 0.0538 0.3795 0.753
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0032 0.0159 0.0158
Onchocerca volvulus 0.0032 0.0159 0.0643
Toxoplasma gondii aldehyde dehydrogenase 0.0123 0.0813 0.1536
Brugia malayi Nuclear hormone receptor family member nhr-40 0.002 0.0077 0.0151
Schistosoma mansoni hypothetical protein 0.0186 0.1264 0.1263
Brugia malayi nuclear receptor RXR 0.0011 0.0007 0.0014
Loa Loa (eye worm) hypothetical protein 0.002 0.0074 0.0147
Onchocerca volvulus 0.0018 0.0056 0.0228
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0056 0.0327
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0077 0.0076
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0118 0.0776 0.1462
Schistosoma mansoni neprilysin 0.0186 0.1264 0.1263
Brugia malayi regulator of G-protein signaling egl-10 0.002 0.0074 0.0146
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0055 0.0019
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-12 subunit 0.001 0 0.0001
Toxoplasma gondii peptidase family M13 protein 0.0712 0.504 1
Loa Loa (eye worm) hypothetical protein 0.0538 0.3795 0.753
Brugia malayi Hypothetical zinc metalloproteinase T16A9.4 0.0712 0.504 1
Loa Loa (eye worm) hypothetical protein 0.0526 0.3706 0.7354
Brugia malayi hypothetical protein 0.0038 0.0202 0.04
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.015 0.1007 0.1997
Loa Loa (eye worm) hypothetical protein 0.0526 0.3706 0.7354
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.0412 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0077 0.0151
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0007 0.0014
Brugia malayi Nuclear hormone receptor family member nhr-1 0.002 0.0077 0.0151
Trypanosoma cruzi cysteine peptidase, putative 0.0018 0.0056 0.0298
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0202 0.1178
Echinococcus granulosus regulator of G protein signaling 3 0.002 0.0074 0.0074
Schistosoma mansoni endothelin-converting enzyme-like 1 (damage-induced neuronal endopeptidase) 0.0173 0.1175 0.1174
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0229 0.1571 0.1571
Onchocerca volvulus 0.0249 0.1715 0.6967
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0025 0.0107 0.0123
Echinococcus granulosus Smad4 0.0017 0.0049 0.0049
Loa Loa (eye worm) hypothetical protein 0.002 0.0074 0.0147
Echinococcus multilocularis regulator of G protein signaling 0.002 0.0074 0.0074
Echinococcus granulosus Regulator of G protein signaling 20 0.002 0.0074 0.0074
Trypanosoma cruzi cysteine peptidase, putative 0.0067 0.0412 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0056 0.0327
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.002 0.0077 0.0152
Loa Loa (eye worm) latrophilin receptor protein 2 0.0047 0.0271 0.0537
Schistosoma mansoni cpg binding protein 0.0028 0.013 0.013
Loa Loa (eye worm) hypothetical protein 0.0012 0.0015 0.0029
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.002 0.0074 0.0074
Loa Loa (eye worm) inositol-1 0.0039 0.0209 0.0414
Brugia malayi MH2 domain containing protein 0.0243 0.1672 0.3317
Schistosoma mansoni neprilysin-2 (M13 family) 0.0359 0.2508 0.2508
Brugia malayi Cathepsin L-like precursor 0.0012 0.0015 0.0028
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0016 0.0045 0.0045
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0056 0.0327
Echinococcus granulosus transcription factor btf3 0.0038 0.0202 0.0202
Loa Loa (eye worm) MH2 domain-containing protein 0.0243 0.1672 0.3317
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0039 0.0209 0.1216
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0038 0.0202 0.0202
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0649 0.4589 0.9096
Schistosoma mansoni hypothetical protein 0.0186 0.1264 0.1263
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0056 0.0327
Echinococcus granulosus axis inhibition protein axin 0.002 0.0074 0.0074
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0107 0.0212
Brugia malayi Cathepsin L-like precursor 0.0018 0.0056 0.0111
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.014 0.0937 1
Loa Loa (eye worm) cysteine protease 0.0018 0.0056 0.0112
Schistosoma mansoni family M13 non-peptidase homologue (M13 family) 0.0173 0.1175 0.1174
Brugia malayi hypothetical protein 0.0021 0.0079 0.0156
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0035 0.018 0.0147
Trypanosoma brucei transcription factor BTF3, putative 0.0038 0.0202 0.4281
Loa Loa (eye worm) hypothetical protein 0.0025 0.0107 0.0212
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.0412 1
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0106 0.0691 0.1184
Loa Loa (eye worm) GTP-binding regulatory protein alpha chain 0.001 0 0.0001
Mycobacterium tuberculosis Probable dehydrogenase 0.0106 0.0691 0.1292
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0077 0.0151
Brugia malayi Doublecortin family protein 0.0021 0.0079 0.0156
Mycobacterium tuberculosis Probable reductase 0.0106 0.0691 0.1292
Echinococcus multilocularis transcription factor Dp 1 0.0038 0.02 0.02
Loa Loa (eye worm) hypothetical protein 0.0011 0.0007 0.0015
Loa Loa (eye worm) hypothetical protein 0.002 0.0077 0.0152
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0038 0.0202 0.0202
Leishmania major cathepsin L-like protease 0.0018 0.0056 0.0142
Loa Loa (eye worm) hypothetical protein 0.0103 0.0666 0.1321
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0118 0.0776 0.1462
Echinococcus granulosus histone lysine methyltransferase setb 0.0032 0.0159 0.0159
Brugia malayi hypothetical protein 0.002 0.0074 0.0146
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0159 0.0158
Echinococcus granulosus FTZ F1 alpha 0.002 0.0077 0.0077
Echinococcus multilocularis Regulator of G protein signaling 20 0.002 0.0074 0.0074
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0106 0.0691 0.1292
Brugia malayi glutathione reductase 0.0046 0.0263 0.0522
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0046 0.0263 0.0436
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0018 0.0056 0.05
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0032 0.0159 0.0159
Brugia malayi Regulator of G protein signaling domain containing protein 0.002 0.0074 0.0146
Trichomonas vaginalis inositol monophosphatase, putative 0.0039 0.0209 0.1216
Loa Loa (eye worm) hypothetical protein 0.0025 0.0107 0.0212
Plasmodium vivax multidomain scavenger receptor, putative 0.0021 0.0079 0.153
Schistosoma mansoni cathepsin F (C01 family) 0.0018 0.0056 0.0056
Schistosoma mansoni smad 0.0017 0.0049 0.0048
Entamoeba histolytica cysteine proteinase, putative 0.0018 0.0056 0.0598
Schistosoma mansoni transcription factor btf3 0.0038 0.0202 0.0202
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0047 0.0271 0.0271
Brugia malayi Regulator of G protein signaling domain containing protein 0.002 0.0074 0.0146
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0039 0.0209 0.0327
Loa Loa (eye worm) peptidase family M13 containing protein 0.0526 0.3706 0.7354
Echinococcus multilocularis FTZ F1 alpha 0.002 0.0077 0.0077
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0056 0.0327
Loa Loa (eye worm) fibroinase 0.0018 0.0056 0.0112
Schistosoma mansoni regulator of G protein signaling 0.002 0.0074 0.0074
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0016 0.0045 0.0045
Schistosoma mansoni smad1 5 8 and 0.0017 0.0049 0.0048
Loa Loa (eye worm) hypothetical protein 0.001 0 0.0001
Echinococcus multilocularis mothers against decapentaplegic 5 0.0017 0.0049 0.0049
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0107 0.0802
Leishmania major cathepsin L-like protease 0.0067 0.0412 0.4776
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0159 0.0158
Onchocerca volvulus Cathepsin L homolog 0.0018 0.0056 0.0228
Echinococcus multilocularis endothelin converting enzyme 1 0.0712 0.504 0.504
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.013 0.0258
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0123 0.0813 0.0813
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.0412 1
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0173 0.1175 0.1174
Brugia malayi Calcitonin receptor-like protein seb-1 0.015 0.1007 0.1997
Schistosoma mansoni Smad4 0.0017 0.0049 0.0048
Trypanosoma cruzi major cysteine proteinase, putative 0.0053 0.0309 0.7184
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0018 0.0056 0.0056
Loa Loa (eye worm) hypothetical protein 0.0538 0.3795 0.753
Schistosoma mansoni regulator of G protein signaling 0.002 0.0074 0.0074
Loa Loa (eye worm) hypothetical protein 0.001 0 0.0001
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.0412 1
Echinococcus multilocularis smad 0.0017 0.0049 0.0049
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.014 0.0937 0.5463
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0039 0.0209 0.1216
Mycobacterium ulcerans zinc metalloprotease 0.0712 0.504 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0007 0.0015
Loa Loa (eye worm) hypothetical protein 0.0012 0.0015 0.0029
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.002 0.0077 0.0076
Loa Loa (eye worm) hypothetical protein 0.0353 0.2462 0.4884
Brugia malayi Papain family cysteine protease containing protein 0.0018 0.0056 0.0111
Brugia malayi photoreceptor-specific nuclear receptor 0.002 0.0077 0.0151
Loa Loa (eye worm) Smad1 0.0017 0.0049 0.0096
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0055 0.0019
Brugia malayi Inositol-1 0.0039 0.0209 0.0414
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0229 0.1571 0.1571
Mycobacterium tuberculosis Probable oxidoreductase 0.0118 0.0776 0.1462
Echinococcus multilocularis Polycystic kidney disease protein 0.0021 0.0079 0.0079
Echinococcus multilocularis regulator of G protein signaling 7 0.002 0.0074 0.0074
Loa Loa (eye worm) hypothetical protein 0.0018 0.0062 0.0123
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.002 0.0077 0.0077
Loa Loa (eye worm) hypothetical protein 0.0018 0.0062 0.0123
Loa Loa (eye worm) hypothetical protein 0.002 0.0077 0.0152
Brugia malayi Pre-SET motif family protein 0.0219 0.1499 0.2974
Schistosoma mansoni hypothetical protein 0.0186 0.1264 0.1263
Echinococcus multilocularis thioredoxin glutathione reductase 0.0046 0.0263 0.0263
Brugia malayi PXA domain containing protein 0.002 0.0074 0.0146
Onchocerca volvulus Cathepsin L homolog 0.0018 0.0056 0.0228
Onchocerca volvulus 0.0028 0.013 0.0527
Loa Loa (eye worm) hypothetical protein 0.002 0.0077 0.0152
Schistosoma mansoni hypothetical protein 0.0186 0.1264 0.1263
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0106 0.0691 0.1292
Entamoeba histolytica hypothetical protein 0.0038 0.0202 0.2149
Echinococcus multilocularis regulator of G protein signaling 3 0.002 0.0074 0.0074
Schistosoma mansoni family M13 non-peptidase homologue (M13 family) 0.0359 0.2508 0.2508
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0018 0.0056 0.0112
Schistosoma mansoni lipoxygenase 0.0124 0.0821 0.0821
Plasmodium falciparum acyl-CoA synthetase 0.0018 0.0062 0.0768
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0012 0.0015 0.0029
Schistosoma mansoni polycystin 1-related 0.0021 0.0079 0.0078
Echinococcus multilocularis lipoxygenase domain containing protein 0.0021 0.0079 0.0079
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.002 0.0077 0.0152
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0229 0.1571 0.1571
Brugia malayi Peptidase family M13 containing protein 0.0712 0.504 1
Brugia malayi hypothetical protein 0.0011 0.0007 0.0014
Echinococcus multilocularis Smad4 0.0017 0.0049 0.0049
Plasmodium falciparum basic transcription factor 3b, putative 0.0038 0.0202 0.7195
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0025 0.0107 0.0123
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0229 0.1571 0.3116
Brugia malayi hypothetical protein 0.002 0.0074 0.0146
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.014 0.0937 0.5463
Echinococcus multilocularis cpg binding protein 0.0029 0.0141 0.0141
Echinococcus granulosus TGF beta signal transducer SmadC 0.0017 0.0049 0.0049
Onchocerca volvulus 0.0353 0.2462 1
Schistosoma mansoni hypothetical protein 0.0512 0.3604 0.3604
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0074 0.0429
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.002 0.0074 0.0146
Trypanosoma cruzi cruzipain precursor, putative 0.0067 0.0412 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0077 0.0151
Echinococcus multilocularis RUN 0.0021 0.0079 0.0079
Echinococcus granulosus lipoxygenase domain containing protein 0.0021 0.0079 0.0079
Schistosoma mansoni thyroid hormone receptor 0.002 0.0077 0.0076
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.014 0.0937 0.5463
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0055 0.0019
Loa Loa (eye worm) PXA domain-containing protein 0.002 0.0074 0.0147
Schistosoma mansoni axis inhibition protein axin 0.002 0.0074 0.0074
Onchocerca volvulus 0.0318 0.2213 0.8991
Entamoeba histolytica cysteine proteinase, putative 0.0012 0.0015 0.0152
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0107 0.0123
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0025 0.0107 0.0123
Schistosoma mansoni cpg binding protein 0.0029 0.0141 0.0141
Onchocerca volvulus 0.0018 0.0056 0.0228
Loa Loa (eye worm) hypothetical protein 0.025 0.1722 0.3417
Loa Loa (eye worm) hypothetical protein 0.0021 0.0079 0.0156
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0016 0.0045 0.0045
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0056 0.0327
Loa Loa (eye worm) hypothetical protein 0.0538 0.3795 0.753
Echinococcus multilocularis lipoxygenase domain containing protein 0.0021 0.0079 0.0079
Brugia malayi A-kinase anchor protein 10, precursor 0.002 0.0074 0.0146
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.002 0.0077 0.0152
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.002 0.0074 0.0147
Brugia malayi Nuclear hormone receptor family member nhr-49 0.002 0.0077 0.0151
Brugia malayi beta-NAC-like protein 0.0038 0.0202 0.0401
Schistosoma mansoni retinoic acid receptor RXR 0.002 0.0077 0.0076
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.0007 0.0007
Echinococcus multilocularis regulator of G protein signaling 3 0.002 0.0074 0.0074
Schistosoma mansoni hypothetical protein 0.0103 0.0666 0.0666
Schistosoma mansoni hypothetical protein 0.0021 0.0079 0.0078
Loa Loa (eye worm) hypothetical protein 0.002 0.0077 0.0152
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0056 0.0327
Mycobacterium ulcerans hypothetical protein 0.0025 0.0107 0.0123
Schistosoma mansoni hypothetical protein 0.0038 0.0202 0.0201
Trypanosoma brucei trypanothione reductase 0.0046 0.0263 0.595
Trypanosoma cruzi transcription factor btf3, putative 0.0038 0.0202 0.4281
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.0107 0.1138
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0025 0.0107 0.0123
Loa Loa (eye worm) hypothetical protein 0.0526 0.3706 0.7354
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0065 0.0397 0.0397
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0012 0.0015 0.0083
Echinococcus granulosus cathepsin l1 0.0012 0.0015 0.0015
Brugia malayi PXA domain containing protein 0.002 0.0074 0.0146
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0124 0.0821 0.0821
Loa Loa (eye worm) zinc metallopeptidase 4 0.0173 0.1175 0.2331
Schistosoma mansoni rab6-interacting 0.0021 0.0079 0.0078

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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