Detailed information for compound 659814

Basic information

Technical information
  • TDR Targets ID: 659814
  • Name: N-(2-fluorophenyl)-2-[[4-(2-methylpropyl)-5-p henyl-1,2,4-triazol-3-yl]sulfanyl]acetamide
  • MW: 384.47 | Formula: C20H21FN4OS
  • H donors: 1 H acceptors: 3 LogP: 4.2 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(Cn1c(SCC(=O)Nc2ccccc2F)nnc1c1ccccc1)C
  • InChi: 1S/C20H21FN4OS/c1-14(2)12-25-19(15-8-4-3-5-9-15)23-24-20(25)27-13-18(26)22-17-11-7-6-10-16(17)21/h3-11,14H,12-13H2,1-2H3,(H,22,26)
  • InChiKey: GCHPCMRAAKZWMG-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(2-fluorophenyl)-2-[(4-isobutyl-5-phenyl-1,2,4-triazol-3-yl)sulfanyl]acetamide
  • N-(2-fluorophenyl)-2-[(4-isobutyl-5-phenyl-1,2,4-triazol-3-yl)thio]acetamide
  • N-(2-fluorophenyl)-2-[[4-(2-methylpropyl)-5-phenyl-1,2,4-triazol-3-yl]sulfanyl]ethanamide
  • ZINC01119666

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis esterase, putative 0.0076 0.0091 0.2551
Loa Loa (eye worm) hypothetical protein 0.0076 0.0091 0.1179
Mycobacterium tuberculosis Probable oxidoreductase 0.0462 0.0673 0.1945
Brugia malayi Pre-SET motif family protein 0.0032 0.0025 0.0317
Leishmania major hypothetical protein, conserved 0.0017 0.0002 0.0048
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0063 0.0072 0.0202
Schistosoma mansoni peptidase Clp (S14 family) 0.017 0.0233 0.0232
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.017 0.0233 0.9259
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0462 0.0673 0.1945
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0016 0.0413
Trypanosoma cruzi hypothetical protein, conserved 0.0076 0.0091 0.3606
Mycobacterium leprae conserved hypothetical protein 0.0076 0.0091 0.0258
Trypanosoma cruzi trypanothione reductase, putative 0.0182 0.0251 1
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.0025 0.0024
Leishmania major hypothetical protein, conserved 0.0076 0.0091 0.3606
Mycobacterium tuberculosis Probable lipase LipD 0.0076 0.0091 0.0258
Mycobacterium ulcerans lipase LipD 0.0076 0.0091 0.0258
Trichomonas vaginalis ferritin, putative 0.0018 0.0004 0.0094
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0063 0.0072 0.0071
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.002 0.0531
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.017 0.0233 0.0232
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0017 0.0002 0.0001
Trypanosoma cruzi NADH dehydrogenase, putative 0.0017 0.0002 0.0048
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.002 0.0531
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0033 0.0027 0.0026
Schistosoma mansoni hypothetical protein 0.0135 0.0181 0.018
Onchocerca volvulus 0.0029 0.002 0.0504
Brugia malayi hypothetical protein 0.0119 0.0156 0.201
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0059 0.0065 0.2526
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0063 0.0072 0.3028
Trypanosoma cruzi hypothetical protein, conserved 0.0017 0.0002 0.0048
Toxoplasma gondii thioredoxin reductase 0.0182 0.0251 1
Schistosoma mansoni microtubule-associated protein tau 0.6653 1 1
Trypanosoma brucei NADH dehydrogenase 0.0017 0.0002 0.0048
Mycobacterium tuberculosis Transcriptional regulatory repressor protein (TetR-family) EthR 0.2306 0.3451 1
Echinococcus granulosus expressed protein 0.0018 0.0004 0.0003
Loa Loa (eye worm) hypothetical protein 0.0017 0.0002 0.0028
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0034 0.0932
Loa Loa (eye worm) hypothetical protein 0.0106 0.0136 0.1762
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0017 0.0002 0.0034
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0017 0.0002 0.0034
Trypanosoma brucei PAB1-binding protein , putative 0.0027 0.0018 0.0669
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0063 0.0072 0.2838
Loa Loa (eye worm) hypothetical protein 0.0028 0.0019 0.0248
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0017 0.0002 0.0048
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0049 0.1347
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0063 0.0072 0.0071
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0485 0.0708 0.2045
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0038 0.0034 0.132
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0079 0.0079
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0108 0.014 0.1803
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0106 0.0136 0.1762
Loa Loa (eye worm) beta-lactamase 0.0076 0.0091 0.1179
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0076 0.0091 0.0258
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0048 0.0049 0.0628
Loa Loa (eye worm) hypothetical protein 0.017 0.0233 0.3008
Brugia malayi Pre-SET motif family protein 0.022 0.0309 0.3991
Loa Loa (eye worm) phosphatidylinositol 3 0.0016 0.0001 0.0013
Brugia malayi hypothetical protein 0.0529 0.0774 1
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0018 0.0004 0.0006
Mycobacterium ulcerans bacterioferritin BfrB 0.0018 0.0004 0.0006
Plasmodium vivax glutathione reductase, putative 0.0182 0.0251 1
Echinococcus granulosus mothers against decapentaplegic 5 0.0017 0.0003 0.0002
Schistosoma mansoni disulfide oxidoreductase 0.0017 0.0002 0.0001
Toxoplasma gondii hypothetical protein 0.0059 0.0065 0.2526
Loa Loa (eye worm) hypothetical protein 0.0076 0.0091 0.1179
Echinococcus granulosus smad 0.0017 0.0003 0.0002
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.017 0.0233 0.9259
Echinococcus granulosus ferritin 0.0018 0.0004 0.0003
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0017 0.0002 0.0001
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0017 0.0002 0.0001
Mycobacterium leprae Probable lipase LipE 0.0076 0.0091 0.0258
Trypanosoma brucei NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0017 0.0002 0.0048
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0048 0.0049 0.1903
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0059 0.0065 0.0182
Schistosoma mansoni ferritin 0.0018 0.0004 0.0003
Brugia malayi hypothetical protein 0.0017 0.0003 0.0042
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0046 0.0047 0.0605
Onchocerca volvulus 0.0108 0.014 0.3895
Echinococcus granulosus lamin 0.0029 0.002 0.0019
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0023 0.0022
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0182 0.0251 0.0723
Echinococcus multilocularis lamin dm0 0.0029 0.002 0.0019
Schistosoma mansoni smad1 5 8 and 0.0017 0.0003 0.0002
Echinococcus granulosus thioredoxin glutathione reductase 0.0183 0.0253 0.0252
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0034 0.0932
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0017 0.0002 0.0001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0016 0.0415
Onchocerca volvulus 0.0029 0.002 0.0504
Trichomonas vaginalis glutamate synthase, putative 0.0017 0.0002 0.0034
Brugia malayi glutamate synthase 0.0017 0.0002 0.0028
Loa Loa (eye worm) hypothetical protein 0.0213 0.0298 0.3847
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0048 0.0049 0.0048
Mycobacterium ulcerans TetR family transcriptional regulator 0.2311 0.3458 1
Echinococcus granulosus intermediate filament protein 0.0029 0.002 0.0019
Brugia malayi intermediate filament protein 0.0029 0.002 0.0258
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.017 0.0233 0.0668
Schistosoma mansoni glutamate synthase 0.0017 0.0002 0.0001
Leishmania major NADH dehydrogenase, putative 0.0017 0.0002 0.0048
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0048 0.0049 0.1903
Echinococcus multilocularis beta LACTamase domain containing family member 0.0076 0.0091 0.009
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0063 0.0072 0.2838
Loa Loa (eye worm) hypothetical protein 0.0076 0.0091 0.1179
Loa Loa (eye worm) hypothetical protein 0.0029 0.002 0.0258
Schistosoma mansoni lamin 0.0029 0.002 0.0019
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0063 0.0072 0.2803
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.003 0.0827
Schistosoma mansoni ferritin 0.0018 0.0004 0.0003
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0025 0.0024
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0032 0.0025 0.0024
Brugia malayi glutathione reductase 0.0182 0.0251 0.3247
Echinococcus multilocularis tumor protein p63 0.1456 0.217 0.2169
Giardia lamblia GTOR 0.0048 0.0049 0.6651
Echinococcus multilocularis smad 0.0017 0.0003 0.0002
Schistosoma mansoni survival motor neuron protein 0.0108 0.014 0.0139
Leishmania major hypothetical protein, conserved 0.0027 0.0018 0.0669
Brugia malayi MH2 domain containing protein 0.0253 0.0358 0.4618
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0076 0.0091 0.0258
Treponema pallidum bacterioferrin (TpF1) 0.0018 0.0004 0.0092
Entamoeba histolytica hypothetical protein 0.0119 0.0156 1
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0063 0.0072 0.0931
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0063 0.0072 0.0203
Schistosoma mansoni sulfide quinone reductase 0.0017 0.0002 0.0001
Mycobacterium tuberculosis Conserved protein 0.0076 0.0091 0.0258
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0017 0.0002 0.0034
Trypanosoma cruzi hypothetical protein, conserved 0.0076 0.0091 0.3606
Schistosoma mansoni smad1 5 8 and 0.0017 0.0003 0.0002
Trypanosoma brucei trypanothione reductase 0.0182 0.0251 1
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0048 0.0049 0.0048
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0063 0.0072 0.2838
Echinococcus multilocularis microtubule associated protein 2 0.6653 1 1
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0048 0.0049 0.1903
Trypanosoma cruzi NADH dehydrogenase, putative 0.0017 0.0002 0.0048
Plasmodium vivax thioredoxin reductase, putative 0.0182 0.0251 1
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0017 0.0002 0.0001
Trichomonas vaginalis penicillin-binding protein, putative 0.0076 0.0091 0.2551
Mycobacterium tuberculosis Probable dehydrogenase 0.0416 0.0603 0.1742
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0032 0.0025 0.0024
Mycobacterium tuberculosis Conserved protein 0.0076 0.0091 0.0258
Echinococcus granulosus beta LACTamase domain containing family member 0.0076 0.0091 0.009
Echinococcus multilocularis lamin 0.0029 0.002 0.0019
Loa Loa (eye worm) latrophilin receptor protein 2 0.0033 0.0027 0.0354
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0059 0.0065 0.2728
Wolbachia endosymbiont of Brugia malayi bacterioferritin/cytochrome b1 0.0018 0.0004 0.0092
Echinococcus granulosus glutamate synthase 0.0017 0.0002 0.0001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.003 0.0827
Brugia malayi TAR-binding protein 0.0068 0.0079 0.1026
Mycobacterium ulcerans beta-lactamase 0.0076 0.0091 0.0258
Schistosoma mansoni sulfide quinone reductase 0.0017 0.0002 0.0001
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0038 0.0034 0.132
Echinococcus granulosus GPCR family 2 0.0033 0.0027 0.0026
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0106 0.0136 0.1762
Echinococcus granulosus tumor protein p63 0.1456 0.217 0.2169
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0462 0.0673 0.1941
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0111 0.0145 0.0413
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0059 0.0065 0.2526
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0063 0.0072 0.2838
Trichomonas vaginalis D-aminoacylase, putative 0.0076 0.0091 0.2551
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0017 0.0002 0.0001
Treponema pallidum NADH oxidase 0.0063 0.0072 0.3028
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0017 0.0002 0.0001
Schistosoma mansoni transcription factor LCR-F1 0.0119 0.0156 0.0155
Brugia malayi hypothetical protein 0.0027 0.0018 0.0229
Loa Loa (eye worm) thioredoxin reductase 0.0182 0.0251 0.3247
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0048 0.0049 0.1903
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.003 0.0827
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0019 0.0519
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0063 0.0072 0.0202
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0018 0.0004 0.0006
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0063 0.0072 0.2838
Onchocerca volvulus 0.0076 0.0091 0.2526
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0063 0.0072 0.3028
Loa Loa (eye worm) programmed cell death 8 0.0017 0.0002 0.0028
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0017 0.0002 0.0028
Mycobacterium tuberculosis Probable reductase 0.0416 0.0603 0.1742
Loa Loa (eye worm) hypothetical protein 0.0076 0.0091 0.1179
Brugia malayi Thioredoxin reductase 0.0182 0.0251 0.3247
Mycobacterium ulcerans hypothetical protein 0.0076 0.0091 0.0258
Loa Loa (eye worm) MH2 domain-containing protein 0.0017 0.0003 0.0037
Schistosoma mansoni glutamate synthase 0.0017 0.0002 0.0001
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0017 0.0002 0.0001
Trypanosoma cruzi NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0017 0.0002 0.0048
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0063 0.0072 0.3028
Plasmodium falciparum thioredoxin reductase 0.0063 0.0072 0.2803
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.003 0.0827
Trichomonas vaginalis apoptosis inducing factor, putative 0.0017 0.0002 0.0034
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.003 0.0827
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0076 0.0091 0.009
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0063 0.0072 0.2838
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0033 0.0027 0.0354
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0135 0.0181 0.018
Schistosoma mansoni thyroid hormone receptor 0.0146 0.0197 0.0196
Plasmodium falciparum glutathione reductase 0.0182 0.0251 1
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0076 0.0091 0.0258
Trichomonas vaginalis mercuric reductase, putative 0.0063 0.0072 0.2008
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0017 0.0002 0.0001
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.017 0.0233 1
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0416 0.0603 0.1742
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0033 0.0027 0.0026
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0063 0.0072 0.2803
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0048 0.0049 0.3027
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0049 0.1347
Toxoplasma gondii target of rapamycin (TOR), putative 0.0035 0.003 0.1127
Brugia malayi Smad1 0.0017 0.0003 0.0037
Schistosoma mansoni hypothetical protein 0.0033 0.0027 0.0026
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0016 0.0415
Brugia malayi Calcitonin receptor-like protein seb-1 0.0106 0.0136 0.1762
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0079 0.0079
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0063 0.0072 0.2838
Echinococcus multilocularis tar DNA binding protein 0.0068 0.0079 0.0079
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0018 0.0669
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0063 0.0072 0.2838
Toxoplasma gondii LsmAD domain-containing protein 0.0027 0.0018 0.0624
Echinococcus multilocularis glutamate synthase 0.0017 0.0002 0.0001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.003 0.0827
Trypanosoma cruzi target of rapamycin kinase 3 0.0038 0.0034 0.132
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.0025 0.0898
Schistosoma mansoni apoferritin-2 0.0018 0.0004 0.0003
Trichomonas vaginalis penicillin-binding protein, putative 0.0076 0.0091 0.2551
Onchocerca volvulus 0.0076 0.0091 0.2526
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.002 0.0007 0.0229
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0017 0.0002 0.0034
Leishmania major hypothetical protein, conserved 0.0017 0.0002 0.0048
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0033 0.0027 0.0026
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0063 0.0072 0.0071
Entamoeba histolytica hypothetical protein 0.0119 0.0156 1
Brugia malayi MH2 domain containing protein 0.0017 0.0003 0.0037
Loa Loa (eye worm) hypothetical protein 0.0076 0.0091 0.1179
Schistosoma mansoni ferritin light chain 0.0018 0.0004 0.0003
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0063 0.0072 0.2838
Trypanosoma cruzi trypanothione reductase, putative 0.0063 0.0072 0.2838
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0025 0.0024
Schistosoma mansoni hypothetical protein 0.0033 0.0027 0.0026
Toxoplasma gondii NADPH-glutathione reductase 0.0063 0.0072 0.2803
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0029 0.002 0.0258
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0017 0.0002 0.0034
Schistosoma mansoni cellular tumor antigen P53 0.0213 0.0298 0.0297
Echinococcus granulosus survival motor neuron protein 1 0.0529 0.0774 0.0774
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.017 0.0233 0.9259
Schistosoma mansoni lamin 0.0029 0.002 0.0019
Brugia malayi beta-lactamase family protein 0.0076 0.0091 0.1179
Schistosoma mansoni glutamate synthase 0.0017 0.0002 0.0001
Trypanosoma brucei hypothetical protein, conserved 0.0017 0.0002 0.0048
Schistosoma mansoni hypothetical protein 0.0119 0.0156 0.0155
Entamoeba histolytica hypothetical protein 0.0119 0.0156 1
Echinococcus multilocularis thioredoxin glutathione reductase 0.0183 0.0253 0.0252
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0119 0.0156 0.0155
Brugia malayi beta-lactamase family protein 0.0076 0.0091 0.1179
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0016 0.0413
Trichomonas vaginalis D-aminoacylase, putative 0.0076 0.0091 0.2551
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0034 0.0932
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0111 0.0145 0.0413
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0416 0.0603 0.1742
Brugia malayi beta-lactamase 0.0076 0.0091 0.1179
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0018 0.0624
Echinococcus granulosus peptidase Clp S14 family 0.0111 0.0145 0.0144
Loa Loa (eye worm) glutathione reductase 0.0182 0.0251 0.3247
Echinococcus multilocularis peptidase Clp (S14 family) 0.0111 0.0145 0.0144
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.003 0.0827
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.002 0.0531
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0018 0.0669
Loa Loa (eye worm) hypothetical protein 0.0076 0.0091 0.1179
Trypanosoma cruzi 2,4-dienoyl-coa reductase-like protein, putative 0.0017 0.0002 0.0048
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0063 0.0072 0.0202
Schistosoma mansoni ferritin 0.0018 0.0004 0.0003
Echinococcus granulosus TGF beta signal transducer SmadC 0.0017 0.0003 0.0002
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0017 0.0002 0.0028
Mycobacterium ulcerans esterase/lipase LipP 0.0076 0.0091 0.0258
Brugia malayi Latrophilin receptor protein 2 0.0033 0.0027 0.0354
Echinococcus multilocularis ferritin 0.0018 0.0004 0.0003
Loa Loa (eye worm) hypothetical protein 0.0027 0.0018 0.0229
Brugia malayi Probable ClpP-like protease 0.017 0.0233 0.3008
Loa Loa (eye worm) hypothetical protein 0.0033 0.0027 0.0354
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0111 0.0145 0.0413
Echinococcus granulosus tar DNA binding protein 0.0068 0.0079 0.0079
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0063 0.0072 0.2838
Schistosoma mansoni ferritin 0.0018 0.0004 0.0003
Echinococcus granulosus Smad4 0.0017 0.0003 0.0002
Trichomonas vaginalis glutamate synthase, putative 0.0017 0.0002 0.0034
Leishmania major hypothetical protein, conserved 0.0017 0.0002 0.0048
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.0017 0.0002 0.0034
Plasmodium falciparum glutathione reductase 0.0063 0.0072 0.2803
Plasmodium vivax hypothetical protein, conserved 0.0076 0.0091 0.3575
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.017 0.0233 1
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.017 0.0233 0.0232
Brugia malayi latrophilin 2 splice variant baaae 0.0072 0.0086 0.111
Mycobacterium tuberculosis Conserved protein 0.0076 0.0091 0.0258
Schistosoma mansoni smad1 5 8 and 0.0017 0.0003 0.0002
Echinococcus multilocularis Smad4 0.0017 0.0003 0.0002
Loa Loa (eye worm) RNA binding protein 0.0068 0.0079 0.1026
Schistosoma mansoni ferritin light chain 0.0018 0.0004 0.0003
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0063 0.0072 0.2838
Trichomonas vaginalis D-aminoacylase, putative 0.0076 0.0091 0.2551
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0017 0.0002 0.0048
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0017 0.0002 0.0034
Trichomonas vaginalis set domain proteins, putative 0.0251 0.0355 1
Brugia malayi RNA recognition motif domain containing protein 0.0068 0.0079 0.1026
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0019 0.0519
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0017 0.0003 0.0002
Giardia lamblia NADH oxidase lateral transfer candidate 0.0063 0.0072 1
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0063 0.0072 0.2803
Brugia malayi MH1 domain containing protein 0.0017 0.0003 0.0037
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0034 0.0932
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0063 0.0072 0.2838
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0063 0.0072 0.2838
Loa Loa (eye worm) MH1 domain-containing protein 0.0017 0.0003 0.0037
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.022 0.0309 0.3991
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0017 0.0002 0.0001
Entamoeba histolytica hypothetical protein 0.0119 0.0156 1
Mycobacterium ulcerans AcrR family transcriptional regulator 0.2311 0.3458 1
Plasmodium vivax SET domain protein, putative 0.0032 0.0025 0.0898
Brugia malayi MH1 domain containing protein 0.0017 0.0003 0.0037
Loa Loa (eye worm) hypothetical protein 0.0032 0.0025 0.0317
Mycobacterium tuberculosis Probable esterase LipL 0.0076 0.0091 0.0258
Trichomonas vaginalis glutathione reductase, putative 0.0063 0.0072 0.2008
Echinococcus multilocularis mothers against decapentaplegic 5 0.0017 0.0003 0.0002
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0063 0.0072 0.2803
Schistosoma mansoni hypothetical protein 0.0033 0.0027 0.0026
Echinococcus multilocularis expressed protein 0.0018 0.0004 0.0003
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0016 0.0001 0.0013
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0048 0.0049 0.3027
Mycobacterium tuberculosis Probable lipase LipE 0.0076 0.0091 0.0258
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0016 0.0413
Loa Loa (eye worm) hypothetical protein 0.0529 0.0774 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0018 0.0624
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0416 0.0603 0.1742
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0076 0.0091 0.1179
Loa Loa (eye worm) Smad1 0.0017 0.0003 0.0037
Echinococcus multilocularis GPCR, family 2 0.0033 0.0027 0.0026
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.017 0.0233 1
Leishmania major 2,4-dienoyl-coa reductase fadh1, putative 0.0017 0.0002 0.0048
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0048 0.0049 0.0048
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0063 0.0072 0.2838
Onchocerca volvulus 0.0076 0.0091 0.2526
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0416 0.0603 0.1739
Echinococcus multilocularis thyroid hormone receptor alpha 0.0146 0.0197 0.0196
Schistosoma mansoni intermediate filament proteins 0.0029 0.002 0.0019
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0076 0.0091 0.009
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0416 0.0603 0.1742
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0076 0.0091 0.1179
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0049 0.1347
Trypanosoma cruzi hypothetical protein, conserved 0.0017 0.0002 0.0048
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0017 0.0002 0.0034
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0023 0.0011 0.0394
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0079 0.0079
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0063 0.0072 0.2803
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0017 0.0002 0.0034
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0025 0.068
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0017 0.0002 0.0048
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0016 0.0415
Leishmania major 2,4-dienoyl-coa reductase-like protein 0.0017 0.0002 0.0048
Plasmodium falciparum thioredoxin reductase 0.0182 0.0251 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0016 0.0415
Trypanosoma brucei hypothetical protein, conserved 0.0076 0.0091 0.3606
Echinococcus multilocularis survival motor neuron protein 1 0.0529 0.0774 0.0774
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0017 0.0002 0.0034
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0076 0.0091 0.0258
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0017 0.0002 0.0048
Schistosoma mansoni hypothetical protein 0.0017 0.0002 0.0001
Mycobacterium ulcerans transcriptional regulator 0.2311 0.3458 1
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0046 0.0047 0.0605
Trichomonas vaginalis PIKK family atypical protein kinase 0.0041 0.0038 0.105
Mycobacterium leprae Probable transcriptional regulatory repressor protein (TetR-family) EthR 0.2311 0.3458 1
Schistosoma mansoni smad 0.0017 0.0003 0.0002
Trypanosoma brucei 2,4-dienoyl-coa reductase-like protein 0.0017 0.0002 0.0048
Plasmodium vivax ataxin-2 like protein, putative 0.0027 0.0018 0.0624
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0017 0.0002 0.0001
Onchocerca volvulus 0.0213 0.0298 0.8383
Echinococcus multilocularis musashi 0.0029 0.002 0.0019
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0079 0.0079
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.017 0.0233 0.0668
Mycobacterium ulcerans bacterioferritin BfrA 0.0018 0.0004 0.0006
Toxoplasma gondii ABC1 family protein 0.0076 0.0091 0.3575
Trypanosoma cruzi 2,4-dienoyl-coa reductase fadh1, putative 0.0017 0.0002 0.0048
Echinococcus granulosus histone lysine methyltransferase setb 0.0032 0.0025 0.0024
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0068 0.0079 0.1026
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.017 0.0233 0.9259
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0017 0.0002 0.0028
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.017 0.0233 0.0668
Onchocerca volvulus 0.0032 0.0025 0.0635
Mycobacterium leprae PROBABLE BACTERIOFERRITIN BFRA 0.0018 0.0004 0.0006
Leishmania major trypanothione reductase 0.0182 0.0251 1
Onchocerca volvulus 0.0251 0.0355 1
Schistosoma mansoni hypothetical protein 0.0072 0.0086 0.0085
Brugia malayi MH2 domain containing protein 0.0017 0.0003 0.0037
Loa Loa (eye worm) hypothetical protein 0.0072 0.0086 0.111
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0034 0.0932
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0025 0.0024
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0063 0.0072 0.2838
Loa Loa (eye worm) phosphatidylinositol 3 0.0048 0.0049 0.0628
Schistosoma mansoni apoferritin-2 0.0018 0.0004 0.0003
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0017 0.0003 0.0002
Schistosoma mansoni thyroid hormone receptor 0.0146 0.0197 0.0196
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0024 0.0636
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0048 0.0049 0.1903
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0063 0.0072 0.2838
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0017 0.0002 0.0001
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0079 0.0079
Schistosoma mansoni Smad4 0.0017 0.0003 0.0002
Schistosoma mansoni hypothetical protein 0.0108 0.014 0.0139
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0119 0.0156 0.0155
Brugia malayi RNA binding protein 0.0068 0.0079 0.1026
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0462 0.0673 0.1945
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0033 0.0027 0.0026
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0048 0.0049 0.1903
Loa Loa (eye worm) intermediate filament protein 0.0029 0.002 0.0258
Loa Loa (eye worm) MH2 domain-containing protein 0.0253 0.0358 0.4618
Brugia malayi Intermediate filament tail domain containing protein 0.0029 0.002 0.0258
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0135 0.0181 0.018
Echinococcus granulosus lamin dm0 0.0029 0.002 0.0019
Schistosoma mansoni hypothetical protein 0.0033 0.0027 0.0026
Loa Loa (eye worm) transcription factor SMAD2 0.0253 0.0358 0.4618
Loa Loa (eye worm) TAR-binding protein 0.0068 0.0079 0.1026
Mycobacterium tuberculosis Probable hydrolase 0.0076 0.0091 0.0258
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0017 0.0002 0.0028
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.017 0.0233 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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