Detailed information for compound 664506

Basic information

Technical information
  • TDR Targets ID: 664506
  • Name: 7-(difluoromethyl)-N-(2,4-dimethylphenyl)-5-m ethyl-[1,2,4]triazolo[1,5-a]pyrimidine-2-carb oxamide
  • MW: 331.32 | Formula: C16H15F2N5O
  • H donors: 1 H acceptors: 4 LogP: 3.05 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccc(c(c1)C)NC(=O)c1nc2n(n1)c(cc(n2)C)C(F)F
  • InChi: 1S/C16H15F2N5O/c1-8-4-5-11(9(2)6-8)20-15(24)14-21-16-19-10(3)7-12(13(17)18)23(16)22-14/h4-7,13H,1-3H3,(H,20,24)
  • InChiKey: XLQPOGZPTPHXDA-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • ST5286954
  • BAS 09530326
  • ZINC00477224

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium leprae PROBABLE CONSERVED LIPOPROTEIN LPQF 0.0069 0.1576 1
Loa Loa (eye worm) heterochromatin protein 1 0.0079 0.1891 0.2139
Leishmania major eukaryotic initiation factor 4a, putative 0.0101 0.2559 1
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0044 0.0791 0.1306
Loa Loa (eye worm) doublecortin family protein 0.0022 0.007 0.0079
Mycobacterium tuberculosis Class a beta-lactamase BlaC 0.0145 0.3947 1
Schistosoma mansoni lipoxygenase 0.0091 0.2242 0.3225
Brugia malayi eukaryotic initiation factor 4A 0.0101 0.2559 0.2839
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.024 0.6953 1
Schistosoma mansoni zinc finger protein 0.0026 0.0202 0.029
Toxoplasma gondii hydroxyacylglutathione hydrolase 0.0033 0.0439 0.1135
Loa Loa (eye worm) hypothetical protein 0.0155 0.4279 0.4841
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0146 0.3998 0.3998
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.024 0.6953 0.6953
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0062 0.1338 0.1446
Loa Loa (eye worm) hypothetical protein 0.0101 0.2559 0.2895
Trichomonas vaginalis glucosylceramidase, putative 0.0197 0.5589 0.6252
Echinococcus granulosus ETHE1 protein 0.0033 0.0439 0.0439
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.03 0.8839 1
Entamoeba histolytica alkyl sulfatase, putative 0.0033 0.0439 0.0884
Leishmania major eukaryotic initiation factor 4a, putative 0.0101 0.2559 1
Echinococcus granulosus lipoxygenase domain containing protein 0.0022 0.007 0.007
Loa Loa (eye worm) hypothetical protein 0.0039 0.0609 0.0689
Trichomonas vaginalis apoptosis inducing factor, putative 0.0033 0.0439 0.0313
Schistosoma mansoni hypothetical protein 0.0033 0.0439 0.0631
Brugia malayi follicle stimulating hormone receptor 0.0247 0.7172 0.8099
Trichomonas vaginalis beta lactamase domain, putative 0.0033 0.0439 0.0313
Echinococcus granulosus Polycystic kidney disease protein 0.0022 0.007 0.007
Loa Loa (eye worm) hypothetical protein 0.0033 0.0439 0.0497
Entamoeba histolytica rodhanase-like domain containing protein 0.0122 0.3238 1
Schistosoma mansoni rab6-interacting 0.0022 0.007 0.0101
Schistosoma mansoni m-phase inducer phosphatase(cdc25) 0.0122 0.3238 0.4657
Trypanosoma brucei cleavage and polyadenylation specificity factor subunit, putative 0.0033 0.0439 0.1135
Toxoplasma gondii metallo-beta-lactamase domain-containing protein 0.0033 0.0439 0.1135
Schistosoma mansoni hypothetical protein 0.0165 0.4596 0.6611
Trichomonas vaginalis glucosylceramidase, putative 0.03 0.8839 1
Trypanosoma brucei glyoxalase II 0.0033 0.0439 0.1135
Toxoplasma gondii eukaryotic initiation factor-4A, putative 0.0101 0.2559 1
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0129 0.3471 0.3471
Loa Loa (eye worm) hypothetical protein 0.0113 0.2937 0.3323
Loa Loa (eye worm) hypothetical protein 0.005 0.0962 0.1088
Echinococcus granulosus eukaryotic initiation factor 4A 0.0101 0.2559 0.2559
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0101 0.2559 0.2758
Echinococcus granulosus chromobox protein 1 0.0079 0.1891 0.1891
Trypanosoma cruzi glyoxalase II 0.0033 0.0439 0.1522
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0129 0.3471 0.3471
Loa Loa (eye worm) TAR-binding protein 0.0207 0.5916 0.6694
Loa Loa (eye worm) transcription factor SMAD2 0.0257 0.7491 0.8475
Trichomonas vaginalis glucosylceramidase, putative 0.0197 0.5589 0.6252
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0025 0.0167 0.0111
Echinococcus multilocularis geminin 0.0165 0.4596 0.4596
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0207 0.5916 0.6694
Schistosoma mansoni hypothetical protein 0.0022 0.007 0.0101
Entamoeba histolytica type A flavoprotein, putative 0.0033 0.0439 0.0884
Schistosoma mansoni loxhd1 0.0022 0.007 0.0101
Echinococcus granulosus tar DNA binding protein 0.0207 0.5916 0.5916
Onchocerca volvulus Hydroxyacylglutathione hydrolase, mitochondrial homolog 0.0033 0.0439 0.0668
Trichomonas vaginalis glucosylceramidase, putative 0.03 0.8839 1
Echinococcus multilocularis lipoxygenase domain containing protein 0.0022 0.007 0.007
Loa Loa (eye worm) cytochrome P450 family protein 0.0022 0.0091 0.0103
Brugia malayi acetyltransferase, GNAT family protein 0.0146 0.3998 0.4479
Treponema pallidum ATP-dependent RNA helicase 0.0101 0.2559 1
Onchocerca volvulus 0.0033 0.0439 0.0668
Trypanosoma brucei hydroxyacylglutathione hydrolase, putative 0.0033 0.0439 0.1135
Entamoeba histolytica alkyl sulfatase, putative 0.0033 0.0439 0.0884
Loa Loa (eye worm) hypothetical protein 0.0113 0.2937 0.3323
Echinococcus granulosus RUN 0.0022 0.007 0.007
Echinococcus granulosus fetal alzheimer antigen falz 0.0026 0.0197 0.0197
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0025 0.0167 0.0437
Trichomonas vaginalis glucosylceramidase, putative 0.03 0.8839 1
Onchocerca volvulus Glucosylceramidase homolog 0.0197 0.5589 1
Echinococcus multilocularis ETHE1 protein 0.0033 0.0439 0.0439
Trichomonas vaginalis mitotic inducer phosphatase CDC25, putative 0.0122 0.3238 0.3541
Schistosoma mansoni tar DNA-binding protein 0.0207 0.5916 0.8509
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0062 0.1338 0.1338
Trypanosoma cruzi glyoxalase II 0.0033 0.0439 0.1522
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0072 0.1643 0.1643
Loa Loa (eye worm) hydroxyacylglutathione hydrolase 0.0033 0.0439 0.0497
Giardia lamblia Translation initiation factor eIF-4A, putative 0.0101 0.2559 1
Brugia malayi Cytochrome P450 family protein 0.0022 0.0091 0.0024
Loa Loa (eye worm) PHD-finger family protein 0.0024 0.0129 0.0146
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0439 0.0313
Schistosoma mansoni hypothetical protein 0.0033 0.0439 0.0631
Echinococcus multilocularis eukaryotic initiation factor 4A 0.0101 0.2559 0.2559
Schistosoma mansoni tar DNA-binding protein 0.0207 0.5916 0.8509
Brugia malayi PHD-finger family protein 0.0032 0.0393 0.0369
Mycobacterium tuberculosis Probable conserved lipoprotein LpqF 0.0069 0.1576 0.3241
Loa Loa (eye worm) hypothetical protein 0.0022 0.007 0.0079
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0101 0.2559 0.2758
Schistosoma mansoni zinc phosphodiesterase 0.0033 0.0439 0.0631
Onchocerca volvulus 0.0033 0.0439 0.0668
Trichomonas vaginalis beta lactamase domain, putative 0.0033 0.0439 0.0313
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0057 0.1174 0.1329
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0062 0.1338 0.2564
Loa Loa (eye worm) hypothetical protein 0.0033 0.0439 0.0497
Entamoeba histolytica metallo-beta-lactamase family protein 0.0033 0.0439 0.0884
Brugia malayi Rhodanese-like domain containing protein 0.0122 0.3238 0.3613
Brugia malayi Heterochromatin protein 1 0.0079 0.1891 0.2077
Loa Loa (eye worm) hypothetical protein 0.0033 0.0439 0.0497
Schistosoma mansoni hypothetical protein 0.0033 0.0439 0.0631
Trypanosoma brucei beta lactamase 0.0069 0.1576 0.5888
Echinococcus granulosus geminin 0.0165 0.4596 0.4596
Trypanosoma cruzi hydroxyacylglutathione hydrolase, putative 0.0033 0.0439 0.1522
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0045 0.0803 0.2658
Echinococcus multilocularis tumor protein p63 0.0336 1 1
Brugia malayi ethe1-prov protein 0.0033 0.0439 0.0421
Schistosoma mansoni hypothetical protein 0.0165 0.4596 0.6611
Trichomonas vaginalis glucosylceramidase, putative 0.0197 0.5589 0.6252
Loa Loa (eye worm) hypothetical protein 0.0021 0.0058 0.0066
Brugia malayi metallo-beta-lactamase superfamily protein 0.0033 0.0439 0.0421
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0439 0.0313
Echinococcus multilocularis zinc phosphodiesterase 0.0033 0.0439 0.0439
Echinococcus granulosus lipoxygenase domain containing protein 0.0022 0.007 0.007
Echinococcus multilocularis hydroxyacylglutathione hydrolase 0.0033 0.0439 0.0439
Schistosoma mansoni chromobox protein 0.0079 0.1891 0.272
Brugia malayi Chain A, Human Glyoxalase Ii With Cacodylate And Acetate Ions Present In The Active Site. 0.0033 0.0439 0.0421
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.024 0.6953 0.6953
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0101 0.2559 0.2758
Brugia malayi RNA recognition motif domain containing protein 0.0207 0.5916 0.6667
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0062 0.1338 0.4242
Trypanosoma brucei Eukaryotic initiation factor 4A-1 0.0101 0.2559 1
Trichomonas vaginalis glucosylceramidase, putative 0.03 0.8839 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.024 0.6953 0.7866
Onchocerca volvulus 0.0122 0.3238 0.574
Trypanosoma cruzi metallo-beta-lactamase-like protein, putative 0.0033 0.0439 0.1522
Echinococcus granulosus eukaryotic initiation factor 4A III 0.0101 0.2559 0.2559
Plasmodium falciparum histone acetyltransferase GCN5 0.0039 0.0607 0.2158
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0041 0.0678 0.0678
Trichomonas vaginalis cdc25b, putative 0.0122 0.3238 0.3541
Entamoeba histolytica type A flavoprotein, putative 0.0033 0.0439 0.0884
Entamoeba histolytica rodhanase-like domain containing protein 0.0122 0.3238 1
Trichomonas vaginalis glucosylceramidase, putative 0.0197 0.5589 0.6252
Loa Loa (eye worm) hypothetical protein 0.0122 0.3238 0.3663
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0062 0.1338 0.2564
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.024 0.6953 1
Giardia lamblia Histone acetyltransferase GCN5 0.0039 0.0607 0.0794
Echinococcus granulosus histone acetyltransferase KAT2B 0.0139 0.3786 0.3786
Echinococcus granulosus metallo beta lactamase domain containing protein 0.0033 0.0439 0.0439
Schistosoma mansoni zinc phosphodiesterase 0.0033 0.0439 0.0631
Trypanosoma cruzi metallo-beta-lactamase-like protein, putative 0.0033 0.0439 0.1522
Echinococcus multilocularis metallo beta lactamase domain containing protein 0.0033 0.0439 0.0439
Trichomonas vaginalis beta lactamase domain, putative 0.0033 0.0439 0.0313
Trichomonas vaginalis beta lactamase domain, putative 0.0033 0.0439 0.0313
Schistosoma mansoni DEAD box ATP-dependent RNA helicase 0.0101 0.2559 0.3681
Schistosoma mansoni cellular tumor antigen P53 0.0049 0.0941 0.1353
Brugia malayi latrophilin 2 splice variant baaae 0.0039 0.0609 0.0615
Loa Loa (eye worm) hypothetical protein 0.0044 0.0766 0.0867
Trichomonas vaginalis A-type flavoprotein 0.0033 0.0439 0.0313
Entamoeba histolytica hypothetical protein, conserved 0.0033 0.0439 0.0884
Mycobacterium tuberculosis Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog) 0.0101 0.2559 0.6045
Onchocerca volvulus 0.0035 0.0487 0.0756
Echinococcus granulosus zinc finger protein 0.0026 0.0202 0.0202
Trypanosoma cruzi Eukaryotic initiation factor 4A-1 0.0101 0.2559 1
Schistosoma mansoni bromodomain containing protein 0.0076 0.1772 0.2549
Chlamydia trachomatis ribonuclease Z 0.0033 0.0439 0.5
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0041 0.0678 0.0678
Onchocerca volvulus 0.0122 0.3238 0.574
Echinococcus multilocularis eukaryotic initiation factor 4A III 0.0101 0.2559 0.2559
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0439 0.0313
Trichomonas vaginalis bromodomain-containing protein, putative 0.0045 0.0803 0.0733
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0026 0.0197 0.0197
Plasmodium falciparum cytosolic glyoxalase II 0.0033 0.0439 0.1482
Plasmodium vivax hydroxyacyl glutathione hydrolase, putative 0.0033 0.0439 0.1482
Loa Loa (eye worm) hypothetical protein 0.0033 0.0439 0.0497
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0045 0.0803 0.2945
Brugia malayi hypothetical protein 0.0033 0.0439 0.0421
Entamoeba histolytica metallo-beta-lactamase family protein 0.0033 0.0439 0.0884
Echinococcus granulosus zinc phosphodiesterase 0.0033 0.0439 0.0439
Trichomonas vaginalis cdc25c, putative 0.0122 0.3238 0.3541
Trichomonas vaginalis glucosylceramidase, putative 0.0197 0.5589 0.6252
Trichomonas vaginalis m-phase inducer phosphatase, putative 0.0122 0.3238 0.3541
Trichomonas vaginalis beta lactamase domain, putative 0.0033 0.0439 0.0313
Echinococcus multilocularis RUN 0.0022 0.007 0.007
Trichomonas vaginalis chromobox protein, putative 0.0079 0.1891 0.1988
Schistosoma mansoni hydroxyacylglutathione hydrolase (Glyoxalase II) (Glx II) 0.0033 0.0439 0.0631
Echinococcus granulosus chromobox protein 1 0.0079 0.1891 0.1891
Plasmodium vivax unspecified product 0.0033 0.0439 0.1482
Echinococcus multilocularis muscleblind protein 0.0155 0.4279 0.4279
Entamoeba histolytica metallo-beta-lactamase family protein 0.0033 0.0439 0.0884
Trichomonas vaginalis mitotic inducer phosphatase CDC25, putative 0.0122 0.3238 0.3541
Loa Loa (eye worm) hypothetical protein 0.0052 0.1031 0.1166
Entamoeba histolytica acetyltransferase, GNAT family 0.0039 0.0607 0.1432
Loa Loa (eye worm) bromodomain containing protein 0.0024 0.0133 0.015
Brugia malayi MH2 domain containing protein 0.0257 0.7491 0.8463
Trichomonas vaginalis glucosylceramidase, putative 0.0207 0.5922 0.6637
Brugia malayi Muscleblind-like protein 0.0155 0.4279 0.48
Echinococcus multilocularis chromobox protein 1 0.0079 0.1891 0.1891
Echinococcus multilocularis serine protein kinase ATM 0.0025 0.0167 0.0167
Brugia malayi Rhodanese-like domain containing protein 0.0122 0.3238 0.3613
Trichomonas vaginalis mitotic inducer phosphatase CDC25, putative 0.0122 0.3238 0.3541
Trichomonas vaginalis glucosylceramidase, putative 0.0207 0.5922 0.6637
Entamoeba histolytica rodhanase-like domain containing protein 0.0122 0.3238 1
Plasmodium vivax RNA helicase-1, putative 0.0101 0.2559 1
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0439 0.0313
Loa Loa (eye worm) hypothetical protein 0.0081 0.1929 0.2182
Trichomonas vaginalis cdc25b, putative 0.0122 0.3238 0.3541
Schistosoma mansoni chromobox protein 0.0079 0.1891 0.272
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.024 0.6953 0.7849
Echinococcus multilocularis chromobox protein 1 0.0079 0.1891 0.1891
Echinococcus granulosus histone acetyltransferase KAT2B 0.0045 0.0803 0.0803
Plasmodium falciparum eukaryotic initiation factor 4A 0.0101 0.2559 1
Echinococcus multilocularis metallo beta lactamase domain containing protein 0.0033 0.0439 0.0439
Brugia malayi RNA binding protein 0.0207 0.5916 0.6667
Echinococcus multilocularis lipoxygenase domain containing protein 0.0022 0.007 0.007
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0048 0.0897 0.1499
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0791 0.0719
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0791 0.0719
Brugia malayi chromobox protein homolog 3 0.0044 0.0791 0.0822
Mycobacterium ulcerans class a beta-lactamase, BlaC 0.0145 0.3947 1
Trypanosoma cruzi Eukaryotic initiation factor 4A-1 0.0101 0.2559 1
Echinococcus multilocularis muscleblind protein 1 0.0155 0.4279 0.4279
Loa Loa (eye worm) hypothetical protein 0.0057 0.1174 0.1329
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0439 0.0313
Trypanosoma cruzi hydroxyacylglutathione hydrolase, putative 0.0033 0.0439 0.1522
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0062 0.1338 0.2564
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0247 0.7172 0.8114
Echinococcus granulosus metallo beta lactamase domain containing protein 0.0033 0.0439 0.0439
Loa Loa (eye worm) hypothetical protein 0.0044 0.0791 0.0895
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0045 0.0803 0.0733
Schistosoma mansoni tar DNA-binding protein 0.0207 0.5916 0.8509
Echinococcus multilocularis m phase inducer phosphatase(cdc25) 0.0122 0.3238 0.3238
Trichomonas vaginalis glucosylceramidase, putative 0.03 0.8839 1
Echinococcus multilocularis zinc finger protein 0.0026 0.0202 0.0202
Trichomonas vaginalis chromobox protein, putative 0.0079 0.1891 0.1988
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0381 0.0246
Loa Loa (eye worm) hypothetical protein 0.0035 0.0487 0.0551
Loa Loa (eye worm) metallo-beta-lactamase superfamily protein 0.0033 0.0439 0.0497
Trichomonas vaginalis chromobox protein, putative 0.0048 0.0897 0.0842
Brugia malayi metallo-beta-lactamase superfamily protein 0.0033 0.0439 0.0421
Loa Loa (eye worm) hydroxyacylglutathione hydrolase cytoplasmic 0.0033 0.0439 0.0497
Trichomonas vaginalis glucosylceramidase, putative 0.0197 0.5589 0.6252
Onchocerca volvulus Eukaryotic initiation factor 4A homolog 0.0101 0.2559 0.451
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.024 0.6953 0.6953
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0033 0.0439 0.0313
Loa Loa (eye worm) acetyltransferase 0.0146 0.3998 0.4523
Trypanosoma brucei metallo-beta-lactamase-like protein, putative 0.0033 0.0439 0.1135
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0062 0.1338 0.1925
Schistosoma mansoni hypothetical protein 0.0039 0.0609 0.0876
Brugia malayi TAR-binding protein 0.0207 0.5916 0.6667
Onchocerca volvulus 0.0122 0.3238 0.574
Schistosoma mansoni DEAD box ATP-dependent RNA helicase 0.0101 0.2559 0.3681
Echinococcus multilocularis Polycystic kidney disease protein 0.0022 0.007 0.007
Entamoeba histolytica DEAD/DEAH box helicase, putative 0.0101 0.2559 0.779
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.024 0.6953 1
Onchocerca volvulus Putative hydrolase PNKD 0.0033 0.0439 0.0668
Echinococcus multilocularis tar DNA binding protein 0.0207 0.5916 0.5916
Loa Loa (eye worm) hypothetical protein 0.0022 0.007 0.0079
Trichomonas vaginalis chromobox protein, putative 0.0048 0.0897 0.0842
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0146 0.3998 0.575
Brugia malayi Bromodomain containing protein 0.0089 0.2193 0.2421
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0072 0.1643 0.1643
Loa Loa (eye worm) MH2 domain-containing protein 0.0257 0.7491 0.8475
Mycobacterium ulcerans lipoprotein LpqF 0.0069 0.1576 0.3241
Entamoeba histolytica metallo-beta-lactamase superfamily protein 0.0033 0.0439 0.0884
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.03 0.8839 1
Trichomonas vaginalis glucosylceramidase, putative 0.03 0.8839 1
Entamoeba histolytica metallo-beta-lactamase superfamily protein 0.0033 0.0439 0.0884
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0026 0.0197 0.0284
Trichomonas vaginalis beta lactamase domain, putative 0.0033 0.0439 0.0313
Brugia malayi Calcitonin receptor-like protein seb-1 0.0057 0.1174 0.126
Trypanosoma cruzi metallo-beta-lactamase superfamily, putative 0.0033 0.0439 0.1522
Wolbachia endosymbiont of Brugia malayi metallo-beta-lactamase superfamily hydrolase 0.0033 0.0439 0.5
Echinococcus granulosus m phase inducer phosphatasecdc25 0.0122 0.3238 0.3238
Echinococcus granulosus serine protein kinase ATM 0.0025 0.0167 0.0167
Trypanosoma cruzi metallo-beta-lactamase superfamily, putative 0.0033 0.0439 0.1522
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0045 0.0803 0.2658
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0057 0.1174 0.126
Trichomonas vaginalis m-phase inducer phosphatase, putative 0.0122 0.3238 0.3541
Onchocerca volvulus 0.0049 0.0941 0.1578
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0025 0.0167 0.0241
Echinococcus granulosus muscleblind protein 0.0155 0.4279 0.4279
Loa Loa (eye worm) hypothetical protein 0.0155 0.4279 0.4841
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0381 0.0246
Trichomonas vaginalis glucosylceramidase, putative 0.0197 0.5589 0.6252
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0058 0.1207 0.1365
Schistosoma mansoni tar DNA-binding protein 0.0207 0.5916 0.8509
Schistosoma mansoni rab6-interacting 0.0022 0.007 0.0101
Schistosoma mansoni tar DNA-binding protein 0.0207 0.5916 0.8509
Schistosoma mansoni polycystin 1-related 0.0022 0.007 0.0101
Onchocerca volvulus 0.0122 0.3238 0.574
Schistosoma mansoni hypothetical protein 0.0024 0.0129 0.0185
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0439 0.0313
Loa Loa (eye worm) RNA binding protein 0.0207 0.5916 0.6694
Loa Loa (eye worm) hypothetical protein 0.0049 0.0941 0.1064
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0062 0.1338 0.1338
Schistosoma mansoni lipoxygenase 0.0129 0.3471 0.4993
Loa Loa (eye worm) hypothetical protein 0.0122 0.3238 0.3663
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.024 0.6953 0.6953
Brugia malayi Bromodomain containing protein 0.0047 0.0874 0.0917
Echinococcus granulosus hydroxyacylglutathione hydrolase 0.0033 0.0439 0.0439
Trypanosoma cruzi glyoxalase II 0.0033 0.0439 0.1522

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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