Detailed information for compound 677138

Basic information

Technical information
  • TDR Targets ID: 677138
  • Name: 2-chloro-5-(2,5-dioxopyrrolidin-1-yl)benzamid e
  • MW: 252.654 | Formula: C11H9ClN2O3
  • H donors: 1 H acceptors: 3 LogP: 0.21 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1CCC(=O)N1c1ccc(c(c1)C(=O)N)Cl
  • InChi: 1S/C11H9ClN2O3/c12-8-2-1-6(5-7(8)11(13)17)14-9(15)3-4-10(14)16/h1-2,5H,3-4H2,(H2,13,17)
  • InChiKey: OTRUBGRMOYANGW-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-chloro-5-(2,5-dioxo-1-pyrrolidinyl)benzamide
  • 2-chloro-5-succinimido-benzamide
  • ZINC00458545

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium falciparum NAD(P)H-dependent glutamate synthase, putative 0.002 0.008 0.0177
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0232 0.0493
Toxoplasma gondii PAN domain-containing protein 0.0019 0.0072 0.0104
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0488 0.6968 0.8958
Entamoeba histolytica cysteine proteinase, putative 0.0016 0.0029 0.004
Entamoeba histolytica hypothetical protein 0.0035 0.0302 0.0735
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0138 0.1821 0.2264
Echinococcus multilocularis FTZ F1 alpha 0.0027 0.0187 0.0187
Brugia malayi RNA, U transporter 1 0.0082 0.1004 0.2585
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0074 0.0881 0.2242
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0063 0.0715 0.1813
Echinococcus multilocularis ecdysone induced protein 78C 0.0027 0.0187 0.0187
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0698 0.1689
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0027 0.0187 0.0187
Echinococcus granulosus ribosomal protein L19 0.0025 0.0163 0.0163
Schistosoma mansoni phosphoglycerate kinase 0.0171 0.2309 0.2309
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0027 0.0187 0.041
Trichomonas vaginalis 60S ribosomal protein L19, putative 0.0025 0.0163 0.0381
Toxoplasma gondii PAN domain-containing protein 0.0019 0.0072 0.0104
Loa Loa (eye worm) cysteine protease 0.0016 0.0029 0.0066
Toxoplasma gondii PAN domain-containing protein 0.0297 0.4155 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0654 0.2673
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0027 0.0187 0.0481
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.002 0.008 0.008
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0074 0.0881 0.2167
Toxoplasma gondii hypothetical protein 0.0019 0.0072 0.0104
Trypanosoma brucei phosphoglycerate kinase 0.0171 0.2309 0.5891
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0232 0.0232
Schistosoma mansoni hypothetical protein 0.0309 0.4345 0.4345
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0074 0.0881 0.2242
Schistosoma mansoni sulfide quinone reductase 0.002 0.008 0.008
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0074 0.0881 0.3679
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0232 0.0232
Entamoeba histolytica 60S ribosomal protein L19, putative 0.0025 0.0163 0.0381
Loa Loa (eye worm) steroid hormone receptor 0.0027 0.0187 0.043
Trypanosoma cruzi 3-phosphoglycerate kinase, glycosomal 0.0063 0.0715 0.1813
Toxoplasma gondii NADH dehydrogenase (NDH2-II) 0.002 0.008 0.0124
Toxoplasma gondii PAN domain-containing protein 0.0297 0.4155 1
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0654 0.0654
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0018 0.005 0.0052
Toxoplasma gondii hypothetical protein 0.0019 0.0072 0.0104
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0074 0.0881 0.0881
Entamoeba histolytica disulphide oxidoreductase, putative 0.002 0.008 0.017
Trypanosoma cruzi trypanothione reductase, putative 0.0214 0.2937 0.7554
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0074 0.0881 0.2211
Echinococcus granulosus cathepsin l1 0.0016 0.0029 0.0029
Plasmodium falciparum SUMO-activating enzyme subunit 1 0.0048 0.0504 0.1634
Entamoeba histolytica cysteine proteinase, putative 0.0016 0.0029 0.004
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0074 0.0881 0.3594
Schistosoma mansoni microtubule-associated protein tau 0.0694 1 1
Trypanosoma brucei unspecified product 0.0039 0.0368 0.0827
Toxoplasma gondii microneme protein MIC17B 0.0019 0.0072 0.0104
Echinococcus granulosus ecdysone induced protein 78C 0.0027 0.0187 0.0187
Entamoeba histolytica hypothetical protein 0.0035 0.0302 0.0735
Trypanosoma brucei DNA polymerase kappa, putative 0.0057 0.0627 0.1504
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0217 0.0436
Trypanosoma cruzi 60S ribosomal protein L19, putative 0.0025 0.0163 0.0387
Entamoeba histolytica 60S ribosomal protein L19, putative 0.0025 0.0163 0.0381
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0074 0.0881 0.2242
Schistosoma mansoni importin beta-1 0.0029 0.0217 0.0217
Trypanosoma brucei DNA polymerase kappa, putative 0.0057 0.0627 0.1504
Brugia malayi glutamate synthase 0.002 0.008 0.0207
Schistosoma mansoni ubiquitin-activating enzyme E1b 0.0032 0.026 0.026
Plasmodium vivax SUMO-activating enzyme subunit 2, putative 0.0032 0.026 0.0795
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.0163 0.2193 0.2193
Mycobacterium ulcerans dehydrogenase 0.002 0.008 0.0132
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.0698 0.1768
Giardia lamblia Ribosomal protein L19 0.0025 0.0163 0.0381
Schistosoma mansoni nuclear hormone receptor 0.0027 0.0187 0.0187
Brugia malayi PAN domain containing protein 0.0019 0.0072 0.0185
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0029 0.004
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0216 0.0216
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.002 0.008 0.008
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0029 0.004
Trypanosoma brucei unspecified product 0.0039 0.0368 0.0827
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0074 0.0881 0.2065
Brugia malayi PAN domain containing protein 0.0019 0.0072 0.0185
Leishmania major cathepsin L-like protease 0.0062 0.0698 0.1735
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0698 0.0698
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0171 0.2309 0.593
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprB 0.002 0.008 0.0132
Loa Loa (eye worm) glutathione reductase 0.0214 0.2937 0.676
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0698 0.1689
Trypanosoma cruzi DNA polymerase eta, putative 0.0043 0.0427 0.1069
Loa Loa (eye worm) apoptosis regulator protein 0.0163 0.2193 0.5048
Toxoplasma gondii microneme protein MIC4 0.0019 0.0072 0.0104
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0074 0.0881 0.293
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0698 0.1689
Brugia malayi Cathepsin L-like precursor 0.0016 0.0029 0.0074
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0016 0.0029 0.0066
Trichomonas vaginalis 60S ribosomal protein L19, putative 0.0025 0.0163 0.0381
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0074 0.0881 0.3679
Plasmodium vivax thioredoxin reductase, putative 0.0214 0.2937 1
Mycobacterium tuberculosis Probable oxidoreductase 0.0542 0.7769 1
Echinococcus multilocularis cysteine protease 0.0016 0.0029 0.0029
Onchocerca volvulus 0.0019 0.0072 0.0111
Trypanosoma cruzi 60S ribosomal protein L19, putative 0.0025 0.0163 0.0387
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0137 0.0314
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0029 0.004
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0232 0.0232
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0027 0.0187 0.0481
Schistosoma mansoni cathepsin F (C01 family) 0.0016 0.0029 0.0029
Mycobacterium leprae Probable phosphoglycerate kinase Pgk 0.0171 0.2309 0.2898
Echinococcus multilocularis thyroid hormone receptor alpha 0.0027 0.0187 0.0187
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0027 0.0187 0.043
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.002 0.008 0.0078
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0029 0.004
Plasmodium vivax importin-beta 2, putative 0.0029 0.0217 0.0648
Leishmania major 60S ribosomal protein L19, putative 0.0025 0.0163 0.0348
Trypanosoma brucei polo-like protein kinase 0.0278 0.3884 1
Brugia malayi PAN domain containing protein 0.0019 0.0072 0.0185
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.002 0.008 0.017
Brugia malayi hypothetical protein 0.0035 0.0302 0.0778
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0027 0.0187 0.0481
Brugia malayi glutathione reductase 0.0214 0.2937 0.7562
Schistosoma mansoni hypothetical protein 0.0035 0.0302 0.0302
Echinococcus granulosus ephrin type A receptor 4 A 0.0062 0.0706 0.0706
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0029 0.004
Schistosoma mansoni hypothetical protein 0.0164 0.22 0.22
Schistosoma mansoni disulfide oxidoreductase 0.002 0.008 0.008
Trypanosoma cruzi 2,4-dienoyl-coa reductase-like protein, putative 0.002 0.008 0.0173
Loa Loa (eye worm) hypothetical protein 0.0025 0.0163 0.0376
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0029 0.004
Brugia malayi nuclear receptor NHR-88 0.0027 0.0187 0.0481
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0029 0.004
Loa Loa (eye worm) TK/EPH protein kinase 0.0079 0.0954 0.2196
Brugia malayi 60S ribosomal protein L19 0.0025 0.0163 0.042
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0027 0.0187 0.043
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0029 0.004
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0054 0.0592 0.1524
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0027 0.0187 0.043
Loa Loa (eye worm) hypothetical protein 0.0019 0.0072 0.0165
Chlamydia trachomatis phosphoglycerate kinase 0.0171 0.2309 1
Brugia malayi ImpB/MucB/SamB family protein 0.0057 0.0627 0.1615
Toxoplasma gondii microneme protein, putative 0.0019 0.0072 0.0104
Onchocerca volvulus 0.0238 0.3295 0.8473
Loa Loa (eye worm) hypothetical protein 0.0019 0.0072 0.0165
Echinococcus granulosus importin subunit beta 1 0.0029 0.0217 0.0217
Leishmania major cathepsin L-like protease 0.0062 0.0698 0.1735
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.002 0.008 0.008
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0016 0.0029 0.0029
Trichomonas vaginalis DNA polymerase eta, putative 0.0057 0.0627 0.1561
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.002 0.008 0.0207
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0016 0.0029 0.0066
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0027 0.0187 0.0187
Treponema pallidum phosphoglycerate kinase 0.0171 0.2309 0.5764
Brugia malayi Cathepsin L-like precursor 0.0016 0.0029 0.0074
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.002 0.008 0.017
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0698 0.1689
Leishmania major DNA polymerase kappa, putative 0.0057 0.0627 0.1552
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0056 0.0619 0.1565
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0137 0.0314
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0163 0.2193 0.2193
Loa Loa (eye worm) hypothetical protein 0.0082 0.1004 0.2311
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.002 0.008 0.0078
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0282 0.3946 1
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0278 0.3884 0.3884
Schistosoma mansoni hypothetical protein 0.0163 0.2193 0.2193
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0698 0.0698
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0278 0.3884 0.8939
Schistosoma mansoni glutamate synthase 0.002 0.008 0.008
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.0163 0.2193 0.2193
Leishmania major ubiquitin-activating enzyme-like protein 0.0032 0.026 0.06
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0027 0.0187 0.0187
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0074 0.0881 0.2211
Entamoeba histolytica phosphoglycerate kinase, putative 0.0171 0.2309 0.5836
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0171 0.2309 0.593
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.0698 0.1607
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.002 0.008 0.008
Schistosoma mansoni hypothetical protein 0.0163 0.2193 0.2193
Giardia lamblia Phosphoglycerate kinase 0.0171 0.2309 0.5836
Trypanosoma brucei 2,4-dienoyl-coa reductase-like protein 0.002 0.008 0.0078
Onchocerca volvulus 0.0019 0.0072 0.0111
Leishmania major DNA polymerase eta, putative 0.0043 0.0427 0.1033
Brugia malayi Pre-SET motif family protein 0.0209 0.287 0.7389
Loa Loa (eye worm) hypothetical protein 0.003 0.0232 0.0535
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0488 0.6968 0.8958
Brugia malayi Cathepsin L-like precursor 0.0016 0.0029 0.0074
Loa Loa (eye worm) hypothetical protein 0.0019 0.0072 0.0165
Trypanosoma cruzi NADH dehydrogenase, putative 0.002 0.008 0.0173
Mycobacterium ulcerans NADPH dependent 2,4-dienoyl-CoA reductase FadH 0.002 0.008 0.0132
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.0698 0.1797
Trichomonas vaginalis CAMK family protein kinase 0.0278 0.3884 0.9842
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0698 0.0698
Trypanosoma cruzi polo-like protein kinase, putative 0.0278 0.3884 1
Trichomonas vaginalis apoptosis inducing factor, putative 0.002 0.008 0.017
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0063 0.0715 0.178
Trypanosoma cruzi DNA polymerase kappa, putative 0.0057 0.0627 0.1586
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0698 0.1689
Trichomonas vaginalis CAMK family protein kinase 0.0278 0.3884 0.9842
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0282 0.3946 1
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0074 0.0881 0.2242
Mycobacterium ulcerans thioredoxin reductase TrxB2 0.002 0.008 0.0132
Loa Loa (eye worm) hypothetical protein 0.0018 0.005 0.0116
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0027 0.0187 0.0187
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.002 0.008 0.0132
Echinococcus granulosus glutamate synthase 0.002 0.008 0.008
Treponema pallidum NADH oxidase 0.0074 0.0881 0.2072
Giardia lamblia NADH oxidase lateral transfer candidate 0.0074 0.0881 0.2207
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.0698 0.1768
Mycobacterium ulcerans DNA polymerase IV 0.0057 0.0627 0.2554
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.002 0.008 0.008
Trypanosoma brucei DNA polymerase kappa, putative 0.0057 0.0627 0.1504
Echinococcus multilocularis tar DNA binding protein 0.0062 0.0698 0.0698
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0232 0.0232
Toxoplasma gondii thioredoxin reductase 0.0214 0.2937 0.7048
Entamoeba histolytica glutamate synthase beta subunit, putative 0.002 0.008 0.017
Trypanosoma cruzi hypothetical protein, conserved 0.0018 0.005 0.0096
Trypanosoma brucei DNA polymerase IV, putative 0.0057 0.0627 0.1504
Schistosoma mansoni steroid hormone receptor ad4bp 0.0027 0.0187 0.0187
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0027 0.0187 0.0187
Brugia malayi PAN domain containing protein 0.0019 0.0072 0.0185
Brugia malayi polk-prov protein 0.0018 0.005 0.013
Onchocerca volvulus Protein ultraspiracle homolog 0.0027 0.0187 0.041
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0027 0.0187 0.0187
Mycobacterium tuberculosis Probable phosphoglycerate kinase Pgk 0.0171 0.2309 0.2898
Echinococcus granulosus FTZ F1 alpha 0.0027 0.0187 0.0187
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.002 0.008 0.0124
Loa Loa (eye worm) hypothetical protein 0.0144 0.1915 0.4407
Brugia malayi photoreceptor-specific nuclear receptor 0.0027 0.0187 0.0481
Trypanosoma cruzi cysteine peptidase, putative 0.0016 0.0029 0.004
Giardia lamblia DINP protein human, muc B family 0.0057 0.0627 0.1561
Plasmodium falciparum SUMO-activating enzyme subunit 2 0.0032 0.026 0.0795
Onchocerca volvulus 0.0019 0.0072 0.0111
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0029 0.004
Loa Loa (eye worm) PAN domain-containing protein 0.0019 0.0072 0.0165
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0074 0.0881 0.3594
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.002 0.008 0.017
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.002 0.008 0.008
Mycobacterium ulcerans ferredoxin reductase 0.002 0.008 0.0132
Brugia malayi PAN domain containing protein 0.0019 0.0072 0.0185
Onchocerca volvulus 0.0019 0.0072 0.0111
Toxoplasma gondii PAN domain-containing protein 0.0019 0.0072 0.0104
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0057 0.0627 0.0711
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0138 0.1821 0.7839
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.0654 0.0654
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0138 0.1821 0.2264
Schistosoma mansoni phosphoglycerate kinase 0.0171 0.2309 0.2309
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0074 0.0881 0.293
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0027 0.0187 0.0187
Loa Loa (eye worm) hypothetical protein 0.0029 0.0217 0.05
Brugia malayi Cathepsin L-like precursor 0.0016 0.0029 0.0074
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0171 0.2309 0.5836
Brugia malayi ephrin receptor 1 precursor 0.003 0.0227 0.0586
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0282 0.3946 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0698 0.1689
Leishmania major DNA polymerase kappa, putative 0.0018 0.005 0.0056
Plasmodium falciparum type II NADH:ubiquinone oxidoreductase 0.002 0.008 0.0177
Entamoeba histolytica hypothetical protein 0.0024 0.0137 0.0314
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0063 0.0715 0.1813
Plasmodium vivax SET domain protein, putative 0.003 0.0232 0.07
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0016 0.0029 0.004
Leishmania major importin beta-1 subunit, putative 0.0024 0.0137 0.028
Trypanosoma cruzi major cysteine proteinase, putative 0.0048 0.0504 0.1267
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0057 0.0627 0.1552
Entamoeba histolytica serine/threonine protein kinase, putative 0.0278 0.3884 0.9842
Trypanosoma cruzi trypanothione reductase, putative 0.0074 0.0881 0.2242
Trypanosoma cruzi DNA polymerase eta, putative 0.0082 0.1004 0.2559
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0074 0.0881 0.2269
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0027 0.0187 0.0187
Mycobacterium ulcerans phosphoglycerate kinase 0.0171 0.2309 1
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0074 0.0881 0.0881
Loa Loa (eye worm) PAN domain-containing protein 0.0019 0.0072 0.0165
Trichomonas vaginalis CAMK family protein kinase 0.0278 0.3884 0.9842
Loa Loa (eye worm) TAR-binding protein 0.0062 0.0698 0.1607
Toxoplasma gondii phosphoglycerate kinase PGKII 0.0171 0.2309 0.5525
Echinococcus granulosus SUMO activating enzyme subunit 1 0.0048 0.0504 0.0504
Entamoeba histolytica thioredoxin reductase, putative 0.002 0.008 0.017
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.002 0.008 0.008
Brugia malayi ThiF family protein 0.0048 0.0504 0.1298
Entamoeba histolytica pyridine nucleotide-disulfide oxidoreductase family protein 0.002 0.008 0.017
Plasmodium falciparum thioredoxin reductase 0.0214 0.2937 1
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0278 0.3884 0.3884
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0074 0.0881 0.3594
Brugia malayi PAN domain containing protein 0.0019 0.0072 0.0185
Toxoplasma gondii hypothetical protein 0.0048 0.0504 0.1151
Trypanosoma brucei DNA polymerase kappa, putative 0.0057 0.0627 0.1504
Leishmania major trypanothione reductase 0.0214 0.2937 0.7544
Loa Loa (eye worm) ctsf protein 0.0016 0.0029 0.0066
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.002 0.008 0.0207
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0027 0.0187 0.0481
Trichomonas vaginalis 60S ribosomal protein L19, putative 0.0025 0.0163 0.0381
Schistosoma mansoni DNA polymerase IV / kappa 0.0018 0.005 0.005
Loa Loa (eye worm) hypothetical protein 0.0027 0.0187 0.043
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0542 0.7769 1
Toxoplasma gondii ribosomal protein RPL19 0.0025 0.0163 0.0325
Loa Loa (eye worm) hypothetical protein 0.0048 0.0504 0.116
Leishmania major DNA polymerase eta, putative 0.0082 0.1004 0.2529
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0027 0.0187 0.0481
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.002 0.008 0.0173
Schistosoma mansoni cathepsin F (C01 family) 0.0016 0.0029 0.0029
Echinococcus multilocularis dna polymerase eta 0.0082 0.1004 0.1004
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0027 0.0187 0.0187
Plasmodium falciparum glutathione reductase 0.0214 0.2937 1
Giardia lamblia DNA damage repair protein 0.0018 0.005 0.0094
Leishmania major NADH dehydrogenase, putative 0.002 0.008 0.0133
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0698 0.1689
Toxoplasma gondii 1,3(4)-beta-glucanase 0.0019 0.0072 0.0104
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0282 0.3946 1
Echinococcus multilocularis cathepsin L cysteine protease 0.0016 0.0029 0.0029
Loa Loa (eye worm) hypothetical protein 0.0019 0.0072 0.0165
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.002 0.008 0.008
Schistosoma mansoni glutamate synthase 0.002 0.008 0.008
Brugia malayi Thioredoxin reductase 0.0214 0.2937 0.7562
Trichomonas vaginalis set domain proteins, putative 0.0238 0.3295 0.8345
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0029 0.004
Trichomonas vaginalis CAMK family protein kinase 0.0138 0.1817 0.4586
Echinococcus granulosus thioredoxin glutathione reductase 0.0215 0.2952 0.2952
Plasmodium falciparum glutathione reductase 0.0074 0.0881 0.293
Trypanosoma cruzi hypothetical protein, conserved 0.002 0.008 0.0173
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0171 0.2309 0.5836
Echinococcus granulosus phosphoglycerate kinase 1 0.0171 0.2309 0.2309
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0059 0.0654 0.0746
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0074 0.0881 0.3679
Schistosoma mansoni ephrin receptor 0.0062 0.0706 0.0706
Loa Loa (eye worm) PAN domain-containing protein 0.0019 0.0072 0.0165
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0054 0.0592 0.1524
Leishmania major cathepsin L-like protease 0.0062 0.0698 0.1735
Brugia malayi PAN domain containing protein 0.0019 0.0072 0.0185
Echinococcus multilocularis SUMO activating enzyme subunit 1 0.0048 0.0504 0.0504
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0282 0.3946 1
Trichomonas vaginalis disulfide oxidoreductase, putative 0.002 0.008 0.017
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0016 0.0029 0.004
Onchocerca volvulus 0.0027 0.0187 0.041
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0074 0.0881 0.2211
Schistosoma mansoni thyroid hormone receptor 0.0027 0.0187 0.0187
Leishmania major 2,4-dienoyl-coa reductase-like protein 0.002 0.008 0.0133
Toxoplasma gondii non-proton pumping type-II NADH dehydrogenase I 0.002 0.008 0.0124
Brugia malayi Pre-SET motif family protein 0.003 0.0232 0.0599
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0027 0.0187 0.0187
Schistosoma mansoni thyroid hormone receptor 0.0027 0.0187 0.0187
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0654 0.0654
Echinococcus granulosus sulfide:quinone oxidoreductase 0.002 0.008 0.008
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0488 0.6968 0.8958
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.002 0.008 0.0173
Mycobacterium ulcerans monoxygenase 0.002 0.008 0.0132
Mycobacterium ulcerans glutamate synthase subunit beta 0.002 0.008 0.0132
Trypanosoma cruzi DNA polymerase kappa, putative 0.0057 0.0627 0.1586
Brugia malayi Papain family cysteine protease containing protein 0.0016 0.0029 0.0074
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0029 0.004
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0282 0.3946 1
Trypanosoma brucei 60S ribosomal protein L19, putative 0.0025 0.0163 0.0294
Leishmania major hypothetical protein, conserved 0.002 0.008 0.0133
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0057 0.0627 0.0627
Trypanosoma cruzi DNA polymerase kappa, putative 0.0057 0.0627 0.1586
Toxoplasma gondii PAN domain-containing protein 0.0019 0.0072 0.0104
Brugia malayi TAR-binding protein 0.0062 0.0698 0.1797
Toxoplasma gondii PAN/Apple domain-containing protein 0.0019 0.0072 0.0104
Plasmodium falciparum importin beta, putative 0.0029 0.0217 0.0648
Giardia lamblia Kinase, PLK 0.0278 0.3884 0.9842
Schistosoma mansoni serine/threonine protein kinase 0.0278 0.3884 0.3884
Onchocerca volvulus 0.0019 0.0072 0.0111
Trichomonas vaginalis mercuric reductase, putative 0.0074 0.0881 0.2207
Trypanosoma cruzi polo-like protein kinase, putative 0.0278 0.3884 1
Trypanosoma cruzi hypothetical protein, conserved 0.002 0.008 0.0173
Trypanosoma cruzi 2,4-dienoyl-coa reductase fadh1, putative 0.002 0.008 0.0173
Leishmania major hypothetical protein, conserved 0.002 0.008 0.0133
Brugia malayi Cathepsin L-like precursor 0.0016 0.0029 0.0074
Loa Loa (eye worm) hypothetical protein 0.0171 0.2309 0.5314
Echinococcus multilocularis geminin 0.0164 0.22 0.22
Loa Loa (eye worm) hypothetical protein 0.0027 0.0187 0.043
Trichomonas vaginalis disulfide oxidoreductase, putative 0.002 0.008 0.017
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0027 0.0187 0.0187
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0057 0.0627 0.1561
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0232 0.0232
Trypanosoma cruzi DNA polymerase kappa, putative 0.0057 0.0627 0.1586
Onchocerca volvulus Serine\/threonine kinase homolog 0.0278 0.3884 1
Trypanosoma cruzi NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.002 0.008 0.0173
Loa Loa (eye worm) hypothetical protein 0.002 0.008 0.0185
Trypanosoma brucei DNA polymerase eta, putative 0.0082 0.1004 0.2487
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0074 0.0881 0.293
Mycobacterium tuberculosis Probable dehydrogenase 0.0488 0.6968 0.8958
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0214 0.2937 0.3716
Plasmodium falciparum DNA repair protein REV1, putative 0.0018 0.005 0.0074
Echinococcus granulosus geminin 0.0164 0.22 0.22
Trypanosoma cruzi 60S ribosomal protein L19, putative 0.0025 0.0163 0.0387
Onchocerca volvulus 0.002 0.008 0.0133
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0029 0.004
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0027 0.0187 0.0481
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0027 0.0187 0.043
Loa Loa (eye worm) hypothetical protein 0.0027 0.0187 0.043
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0029 0.004
Loa Loa (eye worm) hypothetical protein 0.0062 0.0696 0.1602
Entamoeba histolytica cysteine protease, putative 0.0016 0.0029 0.004
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0059 0.0654 0.1622
Brugia malayi nuclear hormone receptor 0.0027 0.0187 0.0481
Entamoeba histolytica hypothetical protein 0.0035 0.0302 0.0735
Toxoplasma gondii microneme protein MIC17C 0.0019 0.0072 0.0104
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.002 0.008 0.017
Schistosoma mansoni glutamate synthase 0.002 0.008 0.008
Echinococcus granulosus cathepsin l cysteine peptidase 0.0016 0.0029 0.0029
Brugia malayi Importin beta-1 subunit 0.0029 0.0217 0.056
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0698 0.1689
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.002 0.008 0.017
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0027 0.0187 0.0481
Onchocerca volvulus 0.003 0.0232 0.0528
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0027 0.0187 0.0187
Onchocerca volvulus Bile acid receptor homolog 0.0027 0.0187 0.041
Onchocerca volvulus 0.0019 0.0072 0.0111
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0027 0.0187 0.0481
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0074 0.0881 0.2242
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0368 0.0827
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.002 0.008 0.0185
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0488 0.6968 0.8958
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0074 0.0881 0.2242
Echinococcus granulosus cathepsin L cysteine proteinase 0.0016 0.0029 0.0029
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.0654 0.1515
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0027 0.0187 0.0187
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.002 0.008 0.017
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0309 0.4345 1
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.002 0.008 0.008
Echinococcus multilocularis ribosomal protein L19 0.0025 0.0163 0.0163
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0074 0.0881 0.0881
Giardia lamblia Glycerol-3-phosphate dehydrogenase 0.002 0.008 0.017
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0217 0.0457
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0074 0.0881 0.2211
Loa Loa (eye worm) hypothetical protein 0.0144 0.1915 0.4407
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0074 0.0881 0.2167
Trichomonas vaginalis glutamate synthase, putative 0.002 0.008 0.017
Trichomonas vaginalis CAMK family protein kinase 0.0278 0.3884 0.9842
Giardia lamblia Fructose-bisphosphate aldolase 0.0282 0.3946 1
Schistosoma mansoni apoptosis regulator bax 0.0163 0.2193 0.2193
Brugia malayi Phosphoglycerate kinase 0.0171 0.2309 0.5944
Onchocerca volvulus 0.0062 0.0696 0.173
Trichomonas vaginalis glutathione reductase, putative 0.0074 0.0881 0.2207
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0282 0.3946 1
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0027 0.0187 0.0187
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0654 0.2673
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0043 0.0427 0.0965
Toxoplasma gondii selenide, water dikinase 0.002 0.008 0.0124
Echinococcus granulosus muscleblind protein 0.0144 0.1915 0.1915
Trypanosoma cruzi DNA damage repair protein, putative 0.0018 0.005 0.0096
Loa Loa (eye worm) hypothetical protein 0.0163 0.2193 0.5048
Plasmodium vivax phosphoglycerate kinase, putative 0.0171 0.2309 0.7839
Trypanosoma brucei DNA polymerase kappa, putative 0.0057 0.0627 0.1504
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.002 0.008 0.008
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0302 0.0302
Toxoplasma gondii phosphoglycerate kinase PGKI 0.0171 0.2309 0.5525
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0368 0.0827
Schistosoma mansoni RAR-like nuclear receptor 0.0027 0.0187 0.0187
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0217 0.0436
Echinococcus multilocularis SUMO activating enzyme subunit 2 0.0032 0.026 0.026
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0027 0.0187 0.0481
Schistosoma mansoni sulfide quinone reductase 0.002 0.008 0.008
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0209 0.287 0.6605
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0029 0.004
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0232 0.0232
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0027 0.0187 0.0187
Plasmodium vivax NAD(P)H-dependent glutamate synthase, putative 0.002 0.008 0.0177
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0074 0.0881 0.2167
Echinococcus granulosus tar DNA binding protein 0.0062 0.0698 0.0698
Trichomonas vaginalis CAMK family protein kinase 0.0138 0.1817 0.4586
Schistosoma mansoni sumo-1-activating enzyme E1a 0.0048 0.0504 0.0504
Trypanosoma brucei DNA polymerase kappa, putative 0.0057 0.0627 0.1504
Mycobacterium ulcerans NADH dehydrogenase Ndh 0.002 0.008 0.0132
Trypanosoma brucei DNA polymerase kappa, putative 0.0057 0.0627 0.1504
Loa Loa (eye worm) thioredoxin reductase 0.0214 0.2937 0.676
Onchocerca volvulus 0.0019 0.0072 0.0111
Echinococcus granulosus dna polymerase kappa 0.0057 0.0627 0.0627
Schistosoma mansoni 60S ribosomal protein L19 0.0025 0.0163 0.0163
Wolbachia endosymbiont of Brugia malayi phosphoglycerate kinase 0.0171 0.2309 1
Echinococcus multilocularis thioredoxin glutathione reductase 0.0215 0.2952 0.2952
Leishmania major phosphoglycerate kinase B, cytosolic 0.0171 0.2309 0.5914
Loa Loa (eye worm) hypothetical protein 0.0019 0.0072 0.0165
Brugia malayi ecdysteroid receptor 0.0027 0.0187 0.0481
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0542 0.7769 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0072 0.0165
Echinococcus granulosus sumo-activating enzyme subunit 2 0.0032 0.026 0.026
Schistosoma mansoni retinoic acid receptor RXR 0.0027 0.0187 0.0187
Trypanosoma brucei phosphoglycerate kinase, putative 0.0063 0.0715 0.1734
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0302 0.0302
Trypanosoma brucei DNA polymerase IV, putative 0.0057 0.0627 0.1504
Trypanosoma cruzi 60S ribosomal protein L19, putative 0.0025 0.0163 0.0387
Mycobacterium ulcerans NADH dehydrogenase Ndh1 0.002 0.008 0.0132
Brugia malayi Phosphoglycerate kinase 0.0063 0.0715 0.1841
Echinococcus granulosus snurportin 1 0.0309 0.4345 0.4345
Loa Loa (eye worm) hypothetical protein 0.0031 0.0251 0.0579
Trypanosoma cruzi cruzipain precursor, putative 0.0062 0.0698 0.1768
Trypanosoma brucei DNA polymerase kappa, putative 0.0057 0.0627 0.1504
Loa Loa (eye worm) hypothetical protein 0.0027 0.0187 0.043
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.0163 0.2193 0.5647
Trypanosoma brucei phosphoglycerate kinase 0.0171 0.2309 0.5891
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0057 0.0627 0.0627
Echinococcus multilocularis muscleblind protein 0.0144 0.1915 0.1915
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0278 0.3884 1
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.0654 0.0654
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0063 0.0715 0.1813
Brugia malayi PAN domain containing protein 0.0019 0.0072 0.0185
Onchocerca volvulus 0.0019 0.0072 0.0111
Schistosoma mansoni hypothetical protein 0.002 0.008 0.008
Schistosoma mansoni DNA polymerase eta 0.0082 0.1004 0.1004
Trypanosoma cruzi ubiquitin-activating enzyme, putative 0.0027 0.0195 0.0468
Loa Loa (eye worm) hypothetical protein 0.0027 0.0187 0.043
Schistosoma mansoni hypothetical protein 0.0164 0.22 0.22
Brugia malayi serine/threonine-protein kinase plk-2 0.0278 0.3884 1
Brugia malayi Steroid receptor seven-up type 2 0.0027 0.0187 0.0481
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0074 0.0881 0.293
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.002 0.008 0.0124
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0698 0.0698
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0029 0.004
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0027 0.0187 0.0187
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0654 0.2673
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0027 0.0187 0.043
Brugia malayi PAN domain containing protein 0.0019 0.0072 0.0185
Trichomonas vaginalis disulfide oxidoreductase, putative 0.002 0.008 0.017
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0027 0.0187 0.043
Entamoeba histolytica glutamate synthase beta subunit, putative 0.002 0.008 0.017
Trichomonas vaginalis glutamate synthase, putative 0.002 0.008 0.017
Loa Loa (eye worm) programmed cell death 8 0.002 0.008 0.0185
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0698 0.0698
Onchocerca volvulus 0.0019 0.0072 0.0111
Brugia malayi steroid hormone receptor 0.0027 0.0187 0.0481
Loa Loa (eye worm) hypothetical protein 0.0027 0.0187 0.043
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0027 0.0187 0.0187
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0029 0.004
Leishmania major phosphoglycerate kinase C, glycosomal 0.0171 0.2309 0.5914
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0282 0.3946 1
Leishmania major hypothetical protein, conserved 0.002 0.008 0.0133
Toxoplasma gondii microneme protein MIC17A 0.0019 0.0072 0.0104
Trichomonas vaginalis disulfide oxidoreductase, putative 0.002 0.008 0.017
Echinococcus multilocularis ephrin type A receptor 4 A 0.0062 0.0706 0.0706
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0302 0.0302
Plasmodium vivax ferrodoxin reductase, putative 0.002 0.008 0.0177
Loa Loa (eye worm) hypothetical protein 0.0027 0.0187 0.043
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0057 0.0627 0.0627
Schistosoma mansoni hypothetical protein 0.0163 0.2193 0.2193
Echinococcus multilocularis cathepsin L cysteine protease 0.0016 0.0029 0.0029
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.002 0.008 0.0124
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.0163 0.2193 0.2193
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0027 0.0187 0.0481
Mycobacterium tuberculosis Probable reductase 0.0488 0.6968 0.8958
Echinococcus multilocularis cysteine protease 0.0016 0.0029 0.0029
Trichomonas vaginalis 60S ribosomal protein L19, putative 0.0025 0.0163 0.0381
Loa Loa (eye worm) fibroinase 0.0016 0.0029 0.0066
Echinococcus multilocularis phosphoglycerate kinase 1 0.0171 0.2309 0.2309
Mycobacterium tuberculosis Conserved hypothetical protein 0.0057 0.0627 0.0711
Schistosoma mansoni coup transcription factor 0.0027 0.0187 0.0187
Toxoplasma gondii subtilisin SUB12 0.0019 0.0072 0.0104
Echinococcus multilocularis glutamate synthase 0.002 0.008 0.008
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0029 0.004
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0074 0.0881 0.2242
Trypanosoma brucei DNA polymerase kappa, putative 0.0057 0.0627 0.1504
Trypanosoma cruzi DNA damage repair protein, putative 0.0018 0.005 0.0096
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0029 0.004
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.002 0.008 0.0132
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0027 0.0187 0.0187
Trypanosoma cruzi hypothetical protein, conserved 0.0018 0.005 0.0096
Entamoeba histolytica deoxycytidyl transferase, putative 0.0057 0.0627 0.1561
Entamoeba histolytica hypothetical protein 0.0035 0.0302 0.0735
Schistosoma mansoni sumo-1-activating enzyme E1a 0.0044 0.0438 0.0438
Mycobacterium ulcerans hypothetical protein 0.002 0.008 0.0132
Brugia malayi Nuclear hormone receptor-like 1 0.0027 0.0187 0.0481
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.002 0.008 0.008
Trypanosoma brucei 60S ribosomal protein L19, putative 0.0025 0.0163 0.0294
Leishmania major DNA damage repair protein, putative 0.0018 0.005 0.0056
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.0163 0.2193 0.2193
Treponema pallidum fructose-bisphosphate aldolase 0.0282 0.3946 1
Trypanosoma brucei trypanothione reductase 0.0214 0.2937 0.753
Plasmodium falciparum phosphoglycerate kinase 0.0171 0.2309 0.7839
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0232 0.0232
Loa Loa (eye worm) hypothetical protein 0.0019 0.0072 0.0165
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0698 0.1689
Trichomonas vaginalis CAMK family protein kinase 0.0278 0.3884 0.9842
Trypanosoma cruzi ubiquitin-activating enzyme, putative 0.0032 0.026 0.0638
Brugia malayi RNA binding protein 0.0062 0.0698 0.1797
Trichomonas vaginalis CAMK family protein kinase 0.0278 0.3884 0.9842
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0029 0.004
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0027 0.0187 0.0481
Plasmodium falciparum ferrodoxin reductase-like protein 0.002 0.008 0.0177
Giardia lamblia Glutamate synthase 0.002 0.008 0.017
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0029 0.004
Schistosoma mansoni kinase 0.0141 0.1871 0.1871
Mycobacterium ulcerans DNA polymerase IV 0.0057 0.0627 0.2554
Plasmodium vivax 60S ribosomal protein L19, putative 0.0025 0.0163 0.0462
Trichomonas vaginalis disulfide oxidoreductase, putative 0.002 0.008 0.017
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0282 0.3946 1
Toxoplasma gondii NADPH-glutathione reductase 0.0074 0.0881 0.2065
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0542 0.7769 1
Echinococcus granulosus ribosomal protein L19 0.0025 0.0163 0.0163
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0074 0.0881 0.2242
Onchocerca volvulus 0.0019 0.0072 0.0111
Brugia malayi ImpB/MucB/SamB family protein 0.0082 0.1004 0.2585
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0368 0.0827
Plasmodium vivax glutathione reductase, putative 0.0214 0.2937 1
Trypanosoma brucei hypothetical protein, conserved 0.002 0.008 0.0078
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0698 0.1689
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0016 0.0029 0.0029
Plasmodium falciparum thioredoxin reductase 0.0074 0.0881 0.293
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0027 0.0187 0.0481
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0217 0.0217
Mycobacterium ulcerans NADH dehydrogenase 0.002 0.008 0.0132
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.002 0.008 0.0207
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0029 0.004
Toxoplasma gondii ThiF family protein 0.0032 0.026 0.056
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0029 0.004
Brugia malayi PAN domain containing protein 0.0019 0.0072 0.0185
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.0698 0.1768
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0074 0.0881 0.2167
Trypanosoma brucei DNA polymerase kappa, putative 0.0057 0.0627 0.1504
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0488 0.6968 0.8958
Trypanosoma cruzi NADH dehydrogenase, putative 0.002 0.008 0.0173
Echinococcus granulosus dna polymerase eta 0.0082 0.1004 0.1004
Giardia lamblia Thioredoxin reductase 0.002 0.008 0.017
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0057 0.0627 0.1443
Echinococcus multilocularis ribosomal protein L19 0.0025 0.0163 0.0163
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0027 0.0187 0.0187
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0029 0.004
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0698 0.1689
Echinococcus multilocularis microtubule associated protein 2 0.0694 1 1
Trypanosoma brucei ubiquitin-activating enzyme E1, putative 0.0032 0.026 0.0547
Schistosoma mansoni terminal deoxycytidyl transferase 0.0057 0.0627 0.0627
Trypanosoma brucei NADH dehydrogenase 0.002 0.008 0.0078
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0137 0.0319
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0027 0.0187 0.0481
Brugia malayi ThiF family protein 0.0032 0.026 0.067
Echinococcus multilocularis muscleblind protein 1 0.0144 0.1915 0.1915
Brugia malayi Cathepsin L-like precursor 0.0016 0.0029 0.0074
Echinococcus multilocularis snurportin 1 0.0309 0.4345 0.4345
Plasmodium vivax type II NADH:ubiquinone oxidoreductase, putative 0.002 0.008 0.0177
Plasmodium falciparum 60S ribosomal protein L19 0.0025 0.0163 0.0462
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0027 0.0187 0.043
Trypanosoma brucei NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.002 0.008 0.0078
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0018 0.005 0.0052
Trichomonas vaginalis CAMK family protein kinase 0.0278 0.3884 0.9842
Loa Loa (eye worm) hypothetical protein 0.0016 0.0029 0.0066
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0074 0.0881 0.1042
Plasmodium vivax ubiquitin activating enzyme, putative 0.0048 0.0504 0.1634
Trichomonas vaginalis disulfide oxidoreductase, putative 0.002 0.008 0.017
Leishmania major 60S ribosomal protein L19, putative 0.0025 0.0163 0.0348
Trypanosoma brucei DNA polymerase IV, putative 0.0057 0.0627 0.1504
Trypanosoma brucei unspecified product 0.0057 0.0627 0.1504
Plasmodium vivax DNA repair protein REV1, putative 0.0018 0.005 0.0074
Trypanosoma brucei phosphoglycerate kinase 0.0063 0.0715 0.1734
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0282 0.3946 1
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0063 0.0715 0.1813
Onchocerca volvulus 0.0019 0.0072 0.0111
Brugia malayi Muscleblind-like protein 0.0144 0.1915 0.4929
Loa Loa (eye worm) PAN domain-containing protein 0.0019 0.0072 0.0165
Loa Loa (eye worm) PAN domain-containing protein 0.0019 0.0072 0.0165
Loa Loa (eye worm) ThiF family protein 0.0032 0.026 0.0599
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0137 0.0314
Leishmania major 2,4-dienoyl-coa reductase fadh1, putative 0.002 0.008 0.0133
Loa Loa (eye worm) RNA binding protein 0.0062 0.0698 0.1607
Loa Loa (eye worm) hypothetical protein 0.0027 0.0187 0.043
Echinococcus multilocularis dna polymerase kappa 0.0057 0.0627 0.0627

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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