Detailed information for compound 685805

Basic information

Technical information
  • TDR Targets ID: 685805
  • Name: N-[2-[4-(3-chlorophenyl)piperazin-1-yl]sulfon ylethyl]-4-(trifluoromethyl)benzamide
  • MW: 475.912 | Formula: C20H21ClF3N3O3S
  • H donors: 1 H acceptors: 3 LogP: 3.59 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1cccc(c1)N1CCN(CC1)S(=O)(=O)CCNC(=O)c1ccc(cc1)C(F)(F)F
  • InChi: 1S/C20H21ClF3N3O3S/c21-17-2-1-3-18(14-17)26-9-11-27(12-10-26)31(29,30)13-8-25-19(28)15-4-6-16(7-5-15)20(22,23)24/h1-7,14H,8-13H2,(H,25,28)
  • InChiKey: BEHUQOJPSJYZCE-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-[2-[[4-(3-chlorophenyl)-1-piperazinyl]sulfonyl]ethyl]-4-(trifluoromethyl)benzamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0026 0.0021 0.028
Echinococcus multilocularis hexokinase 0.0082 0.0184 0.3692
Loa Loa (eye worm) hypothetical protein 0.004 0.0061 0.081
Brugia malayi hexokinase 0.0082 0.0184 0.2375
Echinococcus multilocularis peregrin 0.0033 0.0041 0.0748
Echinococcus granulosus lysine specific demethylase 6a 0.0026 0.0022 0.0363
Trypanosoma brucei ubiquitin-conjugating enzyme E2, putative 0.0026 0.0022 0.0639
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0189 0.049 1
Loa Loa (eye worm) ube2i2 protein 0.0026 0.0022 0.0287
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.003 0.0035 0.1126
Giardia lamblia PHD finger protein 15 0.003 0.0034 0.979
Brugia malayi hypothetical protein 0.0026 0.0021 0.0217
Leishmania major ubiquitin-conjugating enzyme e2, putative 0.0026 0.0022 0.035
Toxoplasma gondii ThiF family protein 0.0033 0.0042 0.0437
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0058 0.0115 0.1013
Onchocerca volvulus 0.0052 0.0096 0.0993
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0026 0.0022 0.0663
Echinococcus granulosus ubiquitin conjugating enzyme e2 i 0.0026 0.0022 0.035
Brugia malayi Hexokinase family protein 0.0025 0.0021 0.021
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0035 0.0396
Loa Loa (eye worm) hexokinase 0.0025 0.0021 0.0273
Treponema pallidum replicative DNA helicase (dnaB) 0.0399 0.1094 1
Entamoeba histolytica ubiquitin-conjugating enzyme family protein 0.0026 0.0022 0.0639
Mycobacterium leprae Conserved hypothetical protein 0.1178 0.3327 1
Trichomonas vaginalis phosphofructokinase, putative 0.0112 0.027 0.3519
Chlamydia trachomatis replicative DNA helicase 0.0399 0.1094 1
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0026 0.0022 0.0026
Brugia malayi Bromodomain containing protein 0.0033 0.0041 0.0481
Onchocerca volvulus 0.0247 0.0656 1
Echinococcus granulosus SUMO activating enzyme subunit 1 0.005 0.0091 0.1768
Loa Loa (eye worm) jmjC domain-containing protein 0.0026 0.0022 0.0296
Mycobacterium ulcerans replicative DNA helicase DnaB 0.0399 0.1094 1
Brugia malayi PHD-finger family protein 0.0026 0.0021 0.0221
Loa Loa (eye worm) hypothetical protein 0.0073 0.0157 0.2075
Schistosoma mansoni phosphatidylserine receptor 0.0026 0.0022 0.0161
Wolbachia endosymbiont of Brugia malayi replicative DNA helicase 0.0399 0.1094 1
Mycobacterium leprae RECA PROTEIN (RECOMBINASE A) [CONTAINS: Mle RECA INTEIN]. 0.0112 0.0268 0.0376
Loa Loa (eye worm) 6-phosphofructokinase 0.0112 0.027 0.356
Echinococcus granulosus hexokinase 0.0082 0.0184 0.3692
Mycobacterium tuberculosis Conserved hypothetical protein 0.09 0.2529 0.2526
Mycobacterium ulcerans aldehyde dehydrogenase 0.0189 0.049 0.4453
Trichomonas vaginalis phosphofructokinase, putative 0.0112 0.027 0.3519
Trichomonas vaginalis phosphofructokinase, putative 0.0112 0.027 0.3519
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0037 0.0054 0.1017
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.016 0.0407 0.8288
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.016 0.0407 0.8288
Echinococcus granulosus sumo-activating enzyme subunit 2 0.0033 0.0042 0.076
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0021 0.0618
Entamoeba histolytica hexokinase 1 0.0082 0.0184 0.6751
Echinococcus multilocularis PHD finger protein rhinoceros 0.003 0.0034 0.0603
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0026 0.0022 0.0026
Schistosoma mansoni protein phosphatase 2C 0.0026 0.0022 0.0161
Loa Loa (eye worm) twinkle helicase 0.0114 0.0275 0.3627
Echinococcus granulosus phd:f box containing protein 0.0026 0.0022 0.0363
Mycobacterium tuberculosis Probable serine acetyltransferase CysE (sat) 0.0073 0.0156 0.0151
Loa Loa (eye worm) hypothetical protein 0.002 0.0005 0.0064
Entamoeba histolytica ubiquitin-conjugating enzyme family protein 0.0026 0.0022 0.0639
Echinococcus granulosus histone lysine methyltransferase setb 0.0049 0.0087 0.1704
Echinococcus multilocularis ubiquitin conjugating enzyme e2 i 0.0026 0.0022 0.035
Mycobacterium leprae PROBABLE REPLICATIVE DNA HELICASE DNAB replicative DNA helicase 0.0399 0.1094 0.2975
Trichomonas vaginalis phosphofructokinase, putative 0.0112 0.027 0.3519
Schistosoma mansoni jumonji/arid domain-containing protein 0.01 0.0234 0.2103
Treponema pallidum recombinase A 0.0112 0.0268 0.22
Loa Loa (eye worm) hypothetical protein 0.0056 0.0109 0.1434
Brugia malayi jmjC domain containing protein 0.0026 0.0022 0.0233
Plasmodium falciparum SUMO-activating enzyme subunit 2 0.0033 0.0042 0.1258
Wolbachia endosymbiont of Brugia malayi recombinase A 0.0112 0.0268 0.1189
Brugia malayi Pre-SET motif family protein 0.0217 0.057 0.7501
Echinococcus multilocularis JmjC domain containing protein 4 0.0026 0.0022 0.0363
Loa Loa (eye worm) hypothetical protein 0.0044 0.0074 0.0977
Echinococcus granulosus lysine specific demethylase 5A 0.01 0.0234 0.4723
Brugia malayi 6-phosphofructokinase 0.0112 0.027 0.3519
Loa Loa (eye worm) jmjC domain-containing protein 0.01 0.0234 0.3083
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0047 0.0083 0.1098
Mycobacterium ulcerans aldehyde dehydrogenase 0.0189 0.049 0.4453
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0112 0.027 0.0383
Trypanosoma cruzi ubiquitin-activating enzyme, putative 0.0028 0.0029 0.0894
Loa Loa (eye worm) PHD-finger family protein 0.0021 0.0009 0.0116
Entamoeba histolytica phosphofructokinase, putative 0.0112 0.027 1
Brugia malayi jmjC domain containing protein 0.0026 0.0022 0.0233
Brugia malayi phosphofructokinase 0.0112 0.027 0.3519
Onchocerca volvulus 0.0082 0.0184 0.2408
Entamoeba histolytica ankyrin, putative 0.0073 0.0156 0.5707
Loa Loa (eye worm) hexokinase 0.0082 0.0184 0.2424
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0083 0.072
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0021 0.0618
Schistosoma mansoni 6-phosphofructokinase 0.0112 0.027 0.2435
Plasmodium vivax SET domain protein, putative 0.0031 0.0037 0.0963
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0026 0.0022 0.0663
Trichomonas vaginalis set domain proteins, putative 0.0247 0.0656 0.8642
Toxoplasma gondii phosphofructokinase PFKII 0.003 0.0035 0.0288
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0035 0.0396
Schistosoma mansoni Replicative DNA helicase 0.0399 0.1094 1
Leishmania major ATP-dependent phosphofructokinase 0.0112 0.027 0.5468
Trypanosoma brucei hexokinase 0.0082 0.0184 0.6751
Echinococcus granulosus JmjC domain containing protein 4 0.0026 0.0022 0.0363
Trypanosoma cruzi ubiquitin-conjugating enzyme E2, putative 0.0026 0.0022 0.0639
Schistosoma mansoni jumonji domain containing protein 0.014 0.0349 0.3156
Giardia lamblia UBC3 0.0026 0.0022 0.5677
Loa Loa (eye worm) hypothetical protein 0.0049 0.0087 0.1153
Mycobacterium ulcerans transferase 0.007 0.0148 0.1317
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0083 0.1617
Plasmodium vivax hypothetical protein, conserved 0.003 0.0034 0.079
Echinococcus multilocularis zinc finger protein 0.002 0.0006 0.0017
Loa Loa (eye worm) glutaminase 0.0283 0.0758 1
Toxoplasma gondii hypothetical protein 0.005 0.0091 0.148
Chlamydia trachomatis recombinase RecA 0.0112 0.0268 0.22
Brugia malayi Hexokinase family protein 0.0082 0.0184 0.2375
Loa Loa (eye worm) hypothetical protein 0.0026 0.0022 0.0296
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0049 0.0087 0.0759
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0034 0.0274
Schistosoma mansoni hexokinase 0.0082 0.0184 0.1644
Brugia malayi ThiF family protein 0.005 0.0091 0.1138
Echinococcus multilocularis jumonji domain containing 1A 0.0026 0.0022 0.0363
Loa Loa (eye worm) hypothetical protein 0.0026 0.0023 0.0299
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0037 0.0294
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0047 0.0083 0.1041
Toxoplasma gondii phosphofructokinase domain-containing protein 0.003 0.0035 0.0288
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0083 0.072
Plasmodium vivax hexokinase, putative 0.0082 0.0184 1
Loa Loa (eye worm) hexokinase 0.0052 0.0096 0.1263
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0035 0.0396
Onchocerca volvulus 0.0082 0.0184 0.2408
Entamoeba histolytica hexokinase 2 0.0082 0.0184 0.6751
Trichomonas vaginalis ubiquitin-conjugating enzyme rad6, putative 0.0026 0.0022 0.0225
Trypanosoma brucei hexokinase, putative 0.0082 0.0184 0.6751
Echinococcus granulosus hexokinase type 2 0.0082 0.0184 0.3692
Trypanosoma cruzi hexokinase, putative 0.0082 0.0184 0.6751
Loa Loa (eye worm) jmjC domain-containing protein 0.0026 0.0022 0.0296
Entamoeba histolytica acetyltransferase, putative 0.0073 0.0156 0.5707
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0058 0.0115 0.2275
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0034 0.0274
Onchocerca volvulus 0.0082 0.0184 0.2408
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0112 0.027 0.2222
Toxoplasma gondii 6-phosphofructokinase 0.003 0.0035 0.0288
Echinococcus granulosus hexokinase 0.0082 0.0184 0.3692
Schistosoma mansoni aldehyde dehydrogenase 0.0189 0.049 0.4453
Schistosoma mansoni sumo-1-activating enzyme E1a 0.0045 0.0077 0.0667
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0083 0.1617
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0112 0.027 0.0265
Schistosoma mansoni sumo-1-activating enzyme E1a 0.005 0.0091 0.0787
Loa Loa (eye worm) hypothetical protein 0.0026 0.0023 0.0299
Toxoplasma gondii aldehyde dehydrogenase 0.0189 0.049 1
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0217 0.057 0.7517
Echinococcus multilocularis SUMO activating enzyme subunit 1 0.005 0.0091 0.1768
Trichomonas vaginalis 6-phosphofructokinase, putative 0.003 0.0035 0.0396
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0021 0.0618
Mycobacterium ulcerans glutaminase 0.0283 0.0758 0.692
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0023 0.0014 0.0198
Loa Loa (eye worm) hexokinase type II 0.0082 0.0184 0.2424
Echinococcus multilocularis 6 phosphofructokinase 0.0112 0.027 0.5468
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0028 0.0028 0.0479
Trypanosoma cruzi DNA repair protein, putative 0.0034 0.0046 0.1557
Trypanosoma cruzi DNA repair protein, putative 0.0034 0.0046 0.1557
Loa Loa (eye worm) hypothetical protein 0.003 0.0034 0.0449
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0189 0.049 0.0485
Onchocerca volvulus 0.0031 0.0037 0.0045
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0028 0.0028 0.0479
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.003 0.0035 0.0829
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0058 0.0115 0.2275
Echinococcus multilocularis jumonji domain containing protein 0.0042 0.0068 0.1301
Echinococcus multilocularis SUMO activating enzyme subunit 2 0.0033 0.0042 0.076
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0035 0.0396
Echinococcus granulosus fetal alzheimer antigen falz 0.0023 0.0014 0.0198
Echinococcus multilocularis phd:f box containing protein 0.0026 0.0022 0.0363
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0023 0.0014 0.0088
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0058 0.0115 0.1013
Loa Loa (eye worm) PHD-finger family protein 0.003 0.0034 0.0449
Echinococcus granulosus dynactin 5 p25 0.0073 0.0156 0.3121
Mycobacterium ulcerans 6-phosphofructokinase 0.0112 0.027 0.2435
Trypanosoma cruzi hexokinase, putative 0.0082 0.0184 0.6751
Loa Loa (eye worm) hypothetical protein 0.0026 0.0022 0.0296
Entamoeba histolytica phosphofructokinase, putative 0.0112 0.027 1
Loa Loa (eye worm) ThiF family protein 0.0033 0.0042 0.055
Echinococcus multilocularis hexokinase 0.0082 0.0184 0.3692
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0058 0.0115 0.1013
Echinococcus granulosus hexokinase 0.0082 0.0184 0.3692
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0058 0.0115 0.2275
Schistosoma mansoni ubiquitin-conjugating enzyme E2 I 0.0026 0.0022 0.0156
Echinococcus multilocularis hexokinase type 2 0.0082 0.0184 0.3692
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.003 0.0035 0.0829
Loa Loa (eye worm) 6-phosphofructokinase 0.0112 0.027 0.356
Plasmodium vivax JmjC domain containing protein 0.0026 0.0022 0.0074
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0035 0.0396
Plasmodium falciparum SUMO-activating enzyme subunit 1 0.005 0.0091 0.4265
Leishmania major hexokinase, putative 0.0082 0.0184 0.3692
Echinococcus multilocularis lysine specific demethylase 5A 0.0098 0.0228 0.4606
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0026 0.0022 0.0663
Echinococcus multilocularis lysine specific demethylase 6a 0.0026 0.0022 0.0363
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0058 0.0115 0.011
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0037 0.0054 0.1017
Schistosoma mansoni zinc finger protein 0.002 0.0006 0.0008
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0058 0.0115 0.1464
Loa Loa (eye worm) hypothetical protein 0.0042 0.0068 0.0902
Echinococcus granulosus zinc finger protein 0.002 0.0006 0.0017
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0037 0.0334
Plasmodium vivax ubiquitin activating enzyme, putative 0.005 0.0091 0.4265
Brugia malayi Hexokinase family protein 0.0052 0.0096 0.1207
Brugia malayi PHD-finger family protein 0.003 0.0034 0.0388
Schistosoma mansoni jumonji/arid domain-containing protein 0.01 0.0234 0.2103
Schistosoma mansoni 6-phosphofructokinase 0.0112 0.027 0.2435
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0189 0.049 1
Brugia malayi jmjC domain containing protein 0.01 0.0234 0.3039
Leishmania major hypothetical protein, conserved 0.0026 0.0022 0.0363
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0005 0.0064
Trypanosoma cruzi ubiquitin-conjugating enzyme E2, putative 0.0026 0.0022 0.0639
Brugia malayi ube2i2 protein 0.0026 0.0022 0.0225
Mycobacterium ulcerans aldehyde dehydrogenase 0.0189 0.049 0.4453
Plasmodium vivax SUMO-conjugating enzyme UBC9, putative 0.0026 0.0022 0.0035
Brugia malayi Bromodomain containing protein 0.004 0.0061 0.0748
Mycobacterium tuberculosis RecA protein (recombinase A) [contains: endonuclease PI-MTUI (MTU RecA intein)]. 0.3216 0.9174 0.9173
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0049 0.0087 0.0759
Leishmania major hexokinase, putative 0.0082 0.0184 0.3692
Echinococcus granulosus PHD finger protein rhinoceros 0.003 0.0034 0.0603
Trypanosoma brucei ubiquitin-activating enzyme E1, putative 0.0033 0.0042 0.1389
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0083 0.1617
Schistosoma mansoni jumonji domain containing protein 0.0026 0.0022 0.0161
Toxoplasma gondii hexokinase 0.0082 0.0184 0.3471
Brugia malayi Bromodomain containing protein 0.0078 0.017 0.2192
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0026 0.0022 0.0161
Echinococcus granulosus 6 phosphofructokinase 0.0112 0.027 0.5468
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.003 0.0035 1
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.003 0.0034 0.0268
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0083 0.1617
Plasmodium falciparum hexokinase 0.0082 0.0184 1
Leishmania major hypothetical protein, conserved 0.0026 0.0021 0.0338
Schistosoma mansoni phd/f-box containing protein 0.0026 0.0022 0.0161
Brugia malayi jmjC domain containing protein 0.0026 0.0022 0.0233
Plasmodium vivax SUMO-activating enzyme subunit 2, putative 0.0033 0.0042 0.1258
Echinococcus multilocularis hexokinase 0.0082 0.0184 0.3692
Entamoeba histolytica phosphofructokinase, putative 0.0112 0.027 1
Trichomonas vaginalis conserved hypothetical protein 0.007 0.0148 0.1903
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0189 0.049 1
Schistosoma mansoni hypothetical protein 0.003 0.0034 0.0268
Leishmania major ubiquitin-activating enzyme-like protein 0.0033 0.0042 0.076
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0062 0.0125 0.2471
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0112 0.027 1
Schistosoma mansoni ubiquitin-activating enzyme E1b 0.0033 0.0042 0.0338
Loa Loa (eye worm) jmjC domain-containing protein 0.0026 0.0022 0.0296
Trypanosoma brucei recA bacterial DNA recombination protein, putative 0.0034 0.0046 0.1557
Plasmodium falciparum SUMO-conjugating enzyme UBC9 0.0026 0.0022 0.0035
Brugia malayi hexokinase type II 0.0026 0.0023 0.0237
Treponema pallidum hexokinase (hxk) 0.0082 0.0184 0.1408
Onchocerca volvulus 0.007 0.0148 0.1835
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0049 0.0087 0.1704
Loa Loa (eye worm) hypothetical protein 0.0068 0.0143 0.1882
Plasmodium vivax 6-phosphofructokinase, putative 0.003 0.0035 0.0829
Plasmodium falciparum phd finger protein, putative 0.003 0.0034 0.079
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0037 0.0294
Brugia malayi Pre-SET motif family protein 0.0031 0.0037 0.0425
Mycobacterium ulcerans recombinase A 0.0112 0.0268 0.2413
Plasmodium falciparum JmjC domain-containing protein, putative 0.0026 0.0022 0.0074
Brugia malayi glutaminase DH11.1 0.0283 0.0758 1
Trypanosoma brucei hexokinase 0.0082 0.0184 0.6751
Schistosoma mansoni aldehyde dehydrogenase 0.0189 0.049 0.4453
Loa Loa (eye worm) hexokinase 0.0082 0.0184 0.2424
Schistosoma mansoni bromodomain containing protein 0.0065 0.0135 0.1198
Brugia malayi jmjC domain containing protein 0.016 0.0407 0.5333
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0112 0.027 1
Echinococcus granulosus jumonji domain containing 1A 0.0026 0.0022 0.0363
Echinococcus granulosus peregrin 0.0033 0.0041 0.0748
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0035 0.0396
Trichomonas vaginalis glutaminase, putative 0.0283 0.0758 1
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0062 0.0125 0.2471
Schistosoma mansoni hypothetical protein 0.0021 0.0009 0.0036
Brugia malayi ThiF family protein 0.0033 0.0042 0.0489
Loa Loa (eye worm) phosphofructokinase 0.0112 0.027 0.356
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0034 0.0593
Schistosoma mansoni glutaminase 0.0283 0.0758 0.692
Onchocerca volvulus Hexokinase homolog 0.0052 0.0096 0.0993
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0037 0.0661
Loa Loa (eye worm) glutaminase 2 0.0283 0.0758 1
Loa Loa (eye worm) hypothetical protein 0.005 0.0091 0.1194
Brugia malayi jmjC domain containing protein 0.0026 0.0022 0.0233
Toxoplasma gondii ubiquitin-conjugating enzyme subfamily protein 0.0026 0.0022 0.0012
Echinococcus granulosus jumonji domain containing protein 0.0042 0.0068 0.1301
Loa Loa (eye worm) jmjC domain-containing protein 0.0062 0.0126 0.1663
Plasmodium vivax 6-phosphofructokinase, putative 0.003 0.0035 0.0829
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0083 0.072
Trypanosoma cruzi ubiquitin-activating enzyme, putative 0.0033 0.0042 0.1389
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0054 0.0104 0.137
Trichomonas vaginalis maltose O-acetyltransferase, putative 0.007 0.0148 0.1903
Brugia malayi 6-phosphofructokinase 0.0112 0.027 0.3519

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.