Detailed information for compound 686530

Basic information

Technical information
  • TDR Targets ID: 686530
  • Name: N-(2-ethoxyphenyl)-2-[[1-(2-hydroxyethyl)-2-o xo-6,7-dihydro-5H-cyclopenta[e]pyrimidin-4-yl ]sulfanyl]acetamide
  • MW: 389.469 | Formula: C19H23N3O4S
  • H donors: 2 H acceptors: 3 LogP: 1.63 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: OCCn1c(=O)nc(c2c1CCC2)SCC(=O)Nc1ccccc1OCC
  • InChi: 1S/C19H23N3O4S/c1-2-26-16-9-4-3-7-14(16)20-17(24)12-27-18-13-6-5-8-15(13)22(10-11-23)19(25)21-18/h3-4,7,9,23H,2,5-6,8,10-12H2,1H3,(H,20,24)
  • InChiKey: QWOAULMGFOLIJA-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(2-ethoxyphenyl)-2-[[1-(2-hydroxyethyl)-2-oxo-6,7-dihydro-5H-cyclopenta[e]pyrimidin-4-yl]thio]acetamide
  • N-(2-ethoxyphenyl)-2-[[1-(2-hydroxyethyl)-2-keto-6,7-dihydro-5H-cyclopenta[e]pyrimidin-4-yl]thio]acetamide
  • N-(2-ethoxyphenyl)-2-[[1-(2-hydroxyethyl)-2-oxo-6,7-dihydro-5H-cyclopenta[e]pyrimidin-4-yl]sulfanyl]ethanamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0005 0.0003 0.0008
Trichomonas vaginalis bromodomain-containing protein, putative 0.0041 0.0467 0.1275
Echinococcus granulosus epidermal growth factor receptor 0.0146 0.1792 0.3945
Schistosoma mansoni ran 0.0021 0.0204 0.0384
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0231 0.0628
Echinococcus multilocularis Smad4 0.0008 0.0042 0.0042
Brugia malayi brahma associated protein 60 kDa 0.0011 0.0076 0.021
Onchocerca volvulus 0.0006 0.0015 0.0042
Brugia malayi transcription factor E74 isoform 0.001 0.0072 0.0197
Brugia malayi PXA domain containing protein 0.0019 0.0177 0.0488
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0097 0.1174 0.3123
Echinococcus multilocularis epidermal growth factor receptor 0.0078 0.0935 0.0935
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0016 0.014 0.2947
Loa Loa (eye worm) hypothetical protein 0.0005 0.0007 0.0019
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0013 0.01 0.0268
Schistosoma mansoni z-protein (S1r protein) 0.0019 0.0177 0.0334
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0066 0.0124
Brugia malayi regulator of G-protein signaling egl-10 0.0019 0.0177 0.0488
Echinococcus multilocularis insulin receptor 0.0047 0.0533 0.0533
Brugia malayi Patched family protein 0.0006 0.0015 0.0042
Onchocerca volvulus 0.0006 0.0015 0.0042
Schistosoma mansoni Smad4 0.0008 0.0042 0.0079
Echinococcus granulosus beta-adrenergic receptor kinase 0.002 0.0197 0.0434
Loa Loa (eye worm) TK/EGFR protein kinase 0.0146 0.1792 0.4766
Brugia malayi MH1 domain containing protein 0.0008 0.0042 0.0116
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0066 0.0066
Brugia malayi Patched family protein 0.0006 0.0015 0.0042
Schistosoma mansoni smad1 5 8 and 0.0008 0.0042 0.0079
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0066 0.0124
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.001 0.0064 0.0064
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0301 0.376 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0066 0.0175
Entamoeba histolytica hypothetical protein 0.0035 0.0388 0.1061
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0041 0.0467 0.1275
Loa Loa (eye worm) hypothetical protein 0.0006 0.0015 0.0041
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0066 0.0145
Schistosoma mansoni thyroid hormone receptor 0.001 0.0066 0.0124
Loa Loa (eye worm) hypothetical protein 0.0118 0.1441 0.3832
Loa Loa (eye worm) hypothetical protein 0.0006 0.0015 0.0041
Loa Loa (eye worm) hypothetical protein 0.001 0.0066 0.0175
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.0064 0.1303
Loa Loa (eye worm) RNA binding protein 0.0062 0.0722 0.192
Brugia malayi protein C24B5.3 0.0006 0.0015 0.0042
Schistosoma mansoni ets 0.001 0.0072 0.0134
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0019 0.0177 0.0334
Echinococcus multilocularis Regulator of G protein signaling 20 0.0019 0.0177 0.0177
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0066 0.0181
Plasmodium vivax ras-related protein Rab-5A, putative 0.0005 0.0003 0.0031
Echinococcus granulosus ewsr:fli fusion protein type 0.001 0.0072 0.0158
Loa Loa (eye worm) hypothetical protein 0.0019 0.0177 0.0472
Plasmodium vivax hypothetical protein, conserved 0.0011 0.0076 0.161
Schistosoma mansoni hypothetical protein 0.0067 0.0784 0.1474
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0066 0.0066
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0066 0.0124
Loa Loa (eye worm) hypothetical protein 0.0006 0.0015 0.0041
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0066 0.0175
Echinococcus multilocularis Upstream activation factor subunit UAF30 0.0011 0.0076 0.0076
Giardia lamblia Kinase, PLK 0.0292 0.3639 1
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0005 0.0007 0.0016
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0204 0.0554
Schistosoma mansoni importin beta-1 0.0028 0.0299 0.0562
Brugia malayi TAR-binding protein 0.0062 0.0722 0.1984
Loa Loa (eye worm) hypothetical protein 0.0005 0.0003 0.0008
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0231 0.0628
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0177 0.048
Brugia malayi PXA domain containing protein 0.0019 0.0177 0.0488
Schistosoma mansoni hypothetical protein 0.004 0.0446 0.0839
Loa Loa (eye worm) hypothetical protein 0.0006 0.0015 0.0041
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0204 0.045
Loa Loa (eye worm) hypothetical protein 0.001 0.0066 0.0175
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0509 0.0956
Toxoplasma gondii SWIB/MDM2 domain-containing protein 0.0011 0.0076 0.1567
Chlamydia trachomatis DNA topoisomerase I 0.0011 0.0076 0.5
Echinococcus granulosus ETS transcription factor Elf 5 0.001 0.0072 0.0158
Echinococcus granulosus ETS transcription factor Elf 2 0.001 0.0072 0.0158
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0299 0.6377
Echinococcus granulosus epidermal growth factor receptor 0.0078 0.0935 0.206
Echinococcus multilocularis protein patched 0.0041 0.0465 0.0465
Brugia malayi hypothetical protein 0.0005 0.0003 0.0008
Toxoplasma gondii patched family protein 0.0006 0.0015 0.0246
Schistosoma mansoni polyomavirus enhancer activator 3 pea3 0.001 0.0072 0.0134
Loa Loa (eye worm) patched family protein 0.0006 0.0015 0.0041
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.0011 0.0076 0.1749
Brugia malayi hypothetical protein 0.0035 0.0388 0.1065
Loa Loa (eye worm) brahma associated protein 0.0011 0.0076 0.0203
Echinococcus granulosus Serine:threonine protein kinase PLK4 0.0229 0.2846 0.6266
Brugia malayi brahma associated protein 60 kDa 0.0011 0.0076 0.021
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0465 0.1271
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0066 0.0181
Schistosoma mansoni tyrosine kinase 0.0078 0.0925 0.1739
Echinococcus multilocularis ETS transcription factor Elf 5 0.001 0.0072 0.0072
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0177 0.048
Schistosoma mansoni gabp alpha 0.0071 0.084 0.1578
Onchocerca volvulus Protein patched homolog 0.0006 0.0015 0.0042
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0722 0.1357
Loa Loa (eye worm) hypothetical protein 0.0006 0.0015 0.0041
Brugia malayi MH2 domain containing protein 0.0008 0.0042 0.0116
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0177 0.0334
Loa Loa (eye worm) hypothetical protein 0.001 0.0072 0.019
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0098 0.1181 0.2221
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0509 0.0509
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.0177 0.0177
Loa Loa (eye worm) hypothetical protein 0.0006 0.0015 0.0041
Echinococcus multilocularis ets variant gene 4 0.001 0.0072 0.0072
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0005 0.0004 0.0003
Echinococcus multilocularis transportin 1 0.0005 0.0009 0.0009
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0204 0.0554
Schistosoma mansoni tyrosine kinase 0.0078 0.0935 0.1759
Brugia malayi Patched family protein 0.0006 0.0015 0.0042
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0066 0.0181
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0066 0.0124
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0066 0.0181
Echinococcus multilocularis expressed protein 0.0363 0.4541 0.4541
Echinococcus multilocularis ras-related protein rab-5 0.0005 0.0003 0.0003
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.0177 0.0177
Echinococcus multilocularis GTP binding protein Parf 0.0005 0.0003 0.0003
Brugia malayi hypothetical protein 0.0006 0.0015 0.0042
Loa Loa (eye worm) TAR-binding protein 0.0062 0.0722 0.192
Brugia malayi steroid hormone receptor 0.001 0.0066 0.0181
Echinococcus granulosus insulin receptor 0.0047 0.0533 0.1173
Schistosoma mansoni hypothetical protein 0.0011 0.0076 0.0144
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0.0177 0.0488
Echinococcus multilocularis ewsr:fli fusion protein type 0.001 0.0072 0.0072
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0066 0.0066
Loa Loa (eye worm) patched family protein 0.0006 0.0015 0.0041
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0066 0.0124
Echinococcus granulosus Regulator of G protein signaling 20 0.0019 0.0177 0.0391
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0066 0.0181
Trichomonas vaginalis DNA helicase recq1, putative 0.0024 0.0239 0.0649
Echinococcus multilocularis Niemann Pick C1 protein 0.0138 0.1687 0.1687
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.001 0.0072 0.019
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0204 0.0562
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0097 0.1174 0.3226
Toxoplasma gondii hypothetical protein 0.0006 0.0015 0.0246
Onchocerca volvulus Mitochondrial Rho GTPase homolog 0.0005 0.0003 0.0008
Brugia malayi DNA-binding protein D-ETS-3 0.001 0.0072 0.0197
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0066 0.0145
Echinococcus multilocularis expressed conserved protein 0.0091 0.1088 0.1088
Brugia malayi MH2 domain containing protein 0.0008 0.0042 0.0116
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0509 0.0956
Plasmodium falciparum histone acetyltransferase GCN5 0.0038 0.0423 1
Loa Loa (eye worm) hypothetical protein 0.0006 0.0015 0.0041
Schistosoma mansoni hypothetical protein 0.0011 0.0076 0.0144
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0008 0.0042 0.0079
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0008 0.0042 0.0042
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0066 0.0181
Schistosoma mansoni hypothetical protein 0.004 0.0446 0.0839
Echinococcus multilocularis 0.0045 0.0514 0.0514
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0231 0.0628
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0066 0.0175
Schistosoma mansoni hypothetical protein 0.0035 0.0388 0.0728
Brugia malayi RNA, U transporter 1 0.008 0.0958 0.2633
Schistosoma mansoni elf1 0.001 0.0072 0.0134
Loa Loa (eye worm) hypothetical protein 0.0006 0.0015 0.0041
Schistosoma mansoni smad 0.0008 0.0042 0.0079
Brugia malayi Patched family protein 0.0006 0.0015 0.0042
Loa Loa (eye worm) transcription factor SMAD2 0.0117 0.1422 0.3783
Loa Loa (eye worm) hypothetical protein 0.0019 0.0177 0.0472
Brugia malayi kap beta 3 protein 0.0005 0.0009 0.0024
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0197 0.0371
Schistosoma mansoni serine/threonine protein kinase 0.0292 0.3639 0.6841
Plasmodium vivax SWIB/MDM2 domain-containing protein, putative 0.0011 0.0076 0.161
Trypanosoma brucei ULK family serine/threonine-protein kinase, putative 0.0007 0.0029 0.0071
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0066 0.0175
Echinococcus granulosus GPCR family 2 0.0031 0.0331 0.0729
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0177 0.0334
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0019 0.0177 0.0472
Brugia malayi Patched related family protein 12 0.0006 0.0015 0.0042
Echinococcus multilocularis bloom syndrome protein 0.0024 0.0239 0.0239
Loa Loa (eye worm) hypothetical protein 0.0006 0.0015 0.0041
Schistosoma mansoni hypothetical protein 0.001 0.0072 0.0134
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0331 0.0331
Loa Loa (eye worm) hypothetical protein 0.0019 0.0177 0.0472
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0076 0.0202
Brugia malayi Protein kinase domain containing protein 0.0047 0.0533 0.1463
Brugia malayi CHE-14 protein 0.0041 0.0465 0.1279
Echinococcus granulosus axis inhibition protein axin 0.0019 0.0177 0.0391
Echinococcus granulosus histone acetyltransferase KAT2B 0.0041 0.0467 0.1027
Loa Loa (eye worm) RecQ helicase 0.0024 0.0239 0.0636
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0066 0.0145
Trichomonas vaginalis CAMK family protein kinase 0.0292 0.3639 1
Echinococcus granulosus GA binding protein alpha chain 0.0071 0.084 0.1849
Onchocerca volvulus 0.0006 0.0015 0.0042
Schistosoma mansoni tyrosine kinase 0.0146 0.1792 0.3368
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0066 0.0181
Schistosoma mansoni brg-1 associated factor 0.0011 0.0076 0.0144
Trypanosoma brucei polo-like protein kinase 0.0292 0.3639 1
Echinococcus granulosus mothers against decapentaplegic 5 0.0008 0.0042 0.0093
Entamoeba histolytica recQ family DNA helicase 0.0005 0.0004 0.0007
Loa Loa (eye worm) hypothetical protein 0.001 0.0066 0.0175
Loa Loa (eye worm) hypothetical protein 0.0005 0.0003 0.0008
Loa Loa (eye worm) TK/INSR protein kinase 0.0047 0.0533 0.1416
Loa Loa (eye worm) hypothetical protein 0.0006 0.0015 0.0041
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0177 0.048
Entamoeba histolytica hypothetical protein 0.0035 0.0388 0.1061
Brugia malayi hypothetical protein 0.0019 0.0177 0.0488
Echinococcus granulosus expressed conserved protein 0.0091 0.1088 0.2397
Loa Loa (eye worm) DNA-binding protein D-ETS-3 0.001 0.0072 0.019
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0177 0.0334
Trichomonas vaginalis CAMK family protein kinase 0.0292 0.3639 1
Echinococcus granulosus protein C ets 2 0.001 0.0072 0.0158
Brugia malayi Niemann-Pick C1 protein precursor 0.0096 0.1162 0.3194
Loa Loa (eye worm) hypothetical protein 0.001 0.0066 0.0175
Echinococcus granulosus SWI:SNF matrix associated 0.0011 0.0076 0.0168
Brugia malayi hypothetical protein 0.0006 0.0015 0.0042
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0019 0.0177 0.0391
Echinococcus multilocularis ETS transcription factor Elf 2 0.001 0.0072 0.0072
Toxoplasma gondii HEAT repeat-containing protein 0.0005 0.0009 0.0108
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0066 0.0181
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0013 0.01 0.0268
Schistosoma mansoni importin-beta 2 0.0005 0.0009 0.0017
Loa Loa (eye worm) hypothetical protein 0.0006 0.0015 0.0041
Echinococcus granulosus ATP dependent DNA helicase Q5 0.001 0.0064 0.0141
Brugia malayi Patched family protein 0.0006 0.0015 0.0042
Brugia malayi SWIB/MDM2 domain containing protein 0.0011 0.0076 0.021
Brugia malayi Patched family protein 0.0006 0.0015 0.0042
Loa Loa (eye worm) hypothetical protein 0.0005 0.0007 0.0019
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0177 0.0334
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0041 0.0467 1
Brugia malayi RNA binding protein 0.0062 0.0722 0.1984
Brugia malayi Patched related family protein 10 0.0006 0.0015 0.0042
Chlamydia trachomatis SWIB complex protein 0.0011 0.0076 0.5
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0204 0.4365
Onchocerca volvulus 0.001 0.0066 0.0181
Plasmodium falciparum lipid/sterol:H+ symporter 0.0006 0.0015 0.0294
Plasmodium vivax transportin, putative 0.0005 0.0009 0.0158
Echinococcus granulosus TGF beta signal transducer SmadC 0.0008 0.0042 0.0093
Brugia malayi Ets-domain containing protein 0.0071 0.084 0.2307
Schistosoma mansoni ets-related 0.001 0.0072 0.0134
Loa Loa (eye worm) hypothetical protein 0.0028 0.0299 0.0795
Brugia malayi hypothetical protein 0.0005 0.0007 0.0019
Loa Loa (eye worm) hypothetical protein 0.0006 0.0015 0.0041
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0066 0.0124
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0204 0.0554
Echinococcus multilocularis Niemann Pick C1 protein 0.0096 0.1162 0.1162
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0066 0.0181
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0388 0.0853
Entamoeba histolytica Ran family GTPase 0.0021 0.0204 0.0558
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0047 0.0533 0.0533
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0066 0.0145
Trypanosoma brucei Importin-beta N-terminal domain/HEAT-like repeat, putative 0.0005 0.0009 0.0016
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.0011 0.0076 0.1749
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0722 0.1357
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0066 0.0181
Echinococcus granulosus Smad4 0.0008 0.0042 0.0093
Brugia malayi nuclear hormone receptor 0.001 0.0066 0.0181
Loa Loa (eye worm) ets-domain-containing protein 0.001 0.0072 0.019
Echinococcus granulosus importin subunit beta 1 0.0028 0.0299 0.0658
Loa Loa (eye worm) hypothetical protein 0.0006 0.0015 0.0041
Schistosoma mansoni hypothetical protein 0.0031 0.0331 0.0623
Loa Loa (eye worm) MH2 domain-containing protein 0.0008 0.0042 0.0112
Toxoplasma gondii DNA topoisomerase domain-containing protein 0.0011 0.0076 0.1567
Onchocerca volvulus 0.0006 0.0015 0.0042
Schistosoma mansoni blooms syndrome DNA helicase 0.0019 0.0176 0.0332
Schistosoma mansoni hypothetical protein 0.004 0.0446 0.0839
Echinococcus multilocularis regulator of G protein signaling 0.0019 0.0177 0.0177
Schistosoma mansoni nuclear hormone receptor 0.001 0.0066 0.0124
Brugia malayi Protein kinase domain containing protein 0.0115 0.1403 0.3856
Echinococcus multilocularis mothers against decapentaplegic 5 0.0008 0.0042 0.0042
Loa Loa (eye worm) hypothetical protein 0.0006 0.0015 0.0041
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0141 0.1728 0.1728
Loa Loa (eye worm) hypothetical protein 0.0005 0.0004 0.001
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.0177 0.0391
Loa Loa (eye worm) hypothetical protein 0.0031 0.0331 0.0881
Echinococcus granulosus Protein patched homolog 1 0.0041 0.0465 0.1025
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0204 0.48
Loa Loa (eye worm) hypothetical protein 0.0006 0.0015 0.0041
Brugia malayi hypothetical protein 0.0006 0.0015 0.0042
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0005 0.0007 0.0013
Brugia malayi Furin-like cysteine rich region family protein 0.0146 0.1792 0.4923
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0066 0.0066
Echinococcus granulosus GTP binding protein Parf 0.0005 0.0003 0.0007
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0197 0.0371
Brugia malayi Calcitonin receptor-like protein seb-1 0.0097 0.1174 0.3226
Loa Loa (eye worm) hypothetical protein 0.0006 0.0015 0.0041
Loa Loa (eye worm) importin-beta domain-containing protein 0.0005 0.0009 0.0024
Brugia malayi hypothetical protein 0.0006 0.0015 0.0042
Brugia malayi Fli-1 protein 0.0215 0.2668 0.7332
Loa Loa (eye worm) patched family protein 0.0006 0.0015 0.0041
Schistosoma mansoni hypothetical protein 0.001 0.0072 0.0134
Brugia malayi MH2 domain containing protein 0.0117 0.1422 0.3908
Brugia malayi Myosin head containing protein 0.0006 0.0015 0.0042
Brugia malayi protein C24B5.3 0.0006 0.0015 0.0042
Brugia malayi A-kinase anchor protein 10, precursor 0.0019 0.0177 0.0488
Entamoeba histolytica hypothetical protein 0.0019 0.0177 0.0484
Entamoeba histolytica hypothetical protein 0.0005 0.0003 0.0004
Brugia malayi hypothetical protein 0.0005 0.0007 0.0019
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0019 0.0177 0.048
Loa Loa (eye worm) hypothetical protein 0.001 0.0066 0.0175
Onchocerca volvulus 0.0006 0.0015 0.0042
Entamoeba histolytica hypothetical protein 0.0035 0.0388 0.1061
Leishmania major importin beta-1 subunit, putative 0.0023 0.0231 0.0628
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.1166 0.3197
Onchocerca volvulus Protein patched homolog 0.0006 0.0015 0.0042
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0021 0.0203 0.4763
Entamoeba histolytica acetyltransferase, GNAT family 0.0038 0.0423 0.1158
Echinococcus multilocularis snurportin 1 0.0301 0.376 0.376
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0299 0.0299
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.001 0.0064 0.0064
Loa Loa (eye worm) hypothetical protein 0.0051 0.0583 0.1551
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0016 0.0143 0.3035
Loa Loa (eye worm) hypothetical protein 0.0005 0.0007 0.0019
Echinococcus granulosus smad 0.0008 0.0042 0.0093
Entamoeba histolytica recQ family helicase, putative 0.0013 0.01 0.0272
Schistosoma mansoni smad1 5 8 and 0.0008 0.0042 0.0079
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0066 0.0181
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.0177 0.0391
Loa Loa (eye worm) RGS-3 protein 0.0019 0.0177 0.0472
Onchocerca volvulus Protein ultraspiracle homolog 0.001 0.0066 0.0181
Brugia malayi Patched family protein 0.0006 0.0015 0.0042
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0204 0.0392
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0066 0.0175
Entamoeba histolytica hypothetical protein 0.0005 0.0003 0.0004
Toxoplasma gondii patched family protein 0.0006 0.0015 0.0246
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.001 0.0066 0.0181
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0292 0.3639 0.8014
Echinococcus granulosus expressed protein 0.0363 0.4541 1
Echinococcus multilocularis ETS transcription factor Elf 2 0.001 0.0072 0.0072
Brugia malayi serine/threonine-protein kinase plk-2 0.0292 0.3639 1
Echinococcus granulosus Niemann Pick C1 protein 0.0138 0.1687 0.3714
Schistosoma mansoni axis inhibition protein axin 0.0019 0.0177 0.0334
Onchocerca volvulus Serine\/threonine kinase homolog 0.0292 0.3639 1
Trichomonas vaginalis CAMK family protein kinase 0.0292 0.3639 1
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0066 0.0181
Brugia malayi ecdysteroid receptor 0.001 0.0066 0.0181
Schistosoma mansoni ets-related 0.0215 0.2668 0.5016
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0197 0.0371
Brugia malayi Nuclear hormone receptor-like 1 0.0005 0.0007 0.0019
Echinococcus granulosus ETS transcription factor Elf 1 0.001 0.0072 0.0158
Loa Loa (eye worm) patched family protein 0.0006 0.0015 0.0041
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0005 0.0007 0.0019
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0204 0.0544
Echinococcus multilocularis GPCR, family 2 0.0031 0.0331 0.0331
Loa Loa (eye worm) PXA domain-containing protein 0.0019 0.0177 0.0472
Echinococcus granulosus tar DNA binding protein 0.0062 0.0722 0.159
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.1166 0.3197
Loa Loa (eye worm) hypothetical protein 0.0006 0.0015 0.0041
Brugia malayi Ras-related protein ypt4 0.0005 0.0003 0.0008
Loa Loa (eye worm) hypothetical protein 0.0006 0.0015 0.0041
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0066 0.0066
Echinococcus granulosus sterol regulatory element binding protein 0.0041 0.0465 0.1025
Loa Loa (eye worm) hypothetical protein 0.0096 0.1162 0.3092
Schistosoma mansoni DNA helicase recq5 0.001 0.0064 0.0121
Echinococcus granulosus transportin 1 0.0005 0.0009 0.002
Trichomonas vaginalis CAMK family protein kinase 0.0292 0.3639 1
Echinococcus granulosus Niemann Pick C1 protein 0.0096 0.1162 0.256
Brugia malayi acetyltransferase, GNAT family protein 0.0141 0.1728 0.4747
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.001 0.0064 0.0176
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0041 0.0467 1
Trichomonas vaginalis CAMK family protein kinase 0.0292 0.3639 1
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0066 0.0124
Loa Loa (eye worm) hypothetical protein 0.0019 0.0177 0.0472
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.0722 0.1984
Loa Loa (eye worm) MH1 domain-containing protein 0.0008 0.0042 0.0112
Brugia malayi hypothetical protein 0.0019 0.0177 0.0488
Brugia malayi Smad1 0.0008 0.0042 0.0116
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0388 0.0388
Loa Loa (eye worm) hypothetical protein 0.001 0.0072 0.019
Loa Loa (eye worm) hypothetical protein 0.0061 0.0709 0.1886
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0041 0.0465 0.1238
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0019 0.0177 0.0177
Loa Loa (eye worm) hypothetical protein 0.001 0.0066 0.0175
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0231 0.0628
Echinococcus multilocularis protein dispatched 1 0.0047 0.0539 0.0539
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0331 0.0331
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0331 0.0729
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0066 0.0124
Entamoeba histolytica hypothetical protein 0.0023 0.0231 0.0632
Brugia malayi Patched family protein 0.0006 0.0015 0.0042
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0509 0.112
Trichomonas vaginalis hypothetical protein 0.0005 0.0009 0.0016
Toxoplasma gondii patched family protein 0.0006 0.0015 0.0246
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0299 0.0814
Plasmodium vivax patched family protein, putative 0.0006 0.0015 0.0296
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.0177 0.0391
Loa Loa (eye worm) MH2 domain-containing protein 0.0117 0.1422 0.3783
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0005 0.0007 0.0013
Echinococcus multilocularis leucine rich repeat serine:threonine protein 0.0115 0.1403 0.1403
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0204 0.4336
Echinococcus granulosus rab protein 3 0.0005 0.0003 0.0007
Loa Loa (eye worm) hypothetical protein 0.0006 0.0015 0.0041
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0047 0.0533 0.1173
Brugia malayi Patched family protein 0.0006 0.0015 0.0042
Treponema pallidum ATP-dependent DNA helicase 0.0005 0.0004 0.5
Loa Loa (eye worm) hypothetical protein 0.0067 0.0784 0.2085
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0066 0.0066
Loa Loa (eye worm) hypothetical protein 0.0006 0.0015 0.0041
Entamoeba histolytica hypothetical protein 0.0019 0.0177 0.0484
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.0177 0.0177
Plasmodium falciparum importin beta, putative 0.0028 0.0299 0.705
Echinococcus multilocularis translational activator gcn1 0.0005 0.0009 0.0009
Brugia malayi Ets-domain containing protein 0.0071 0.084 0.2307
Loa Loa (eye worm) hypothetical protein 0.0097 0.1174 0.3123
Schistosoma mansoni tyrosine kinase 0.0078 0.0935 0.1759
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0066 0.0066
Brugia malayi Patched related family protein 4 0.0006 0.0015 0.0042
Loa Loa (eye worm) SWIB/MDM2 domain-containing protein 0.0011 0.0076 0.0203
Loa Loa (eye worm) hypothetical protein 0.0006 0.0015 0.0041
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0005 0.0004 0.0003
Loa Loa (eye worm) hypothetical protein 0.0006 0.0015 0.0041
Brugia malayi Patched family protein 0.0006 0.0015 0.0042
Schistosoma mansoni tyrosine kinase 0.0047 0.0533 0.1001
Leishmania major GTP-binding protein, putative 0.0021 0.0204 0.0554
Trichomonas vaginalis DNA helicase recq, putative 0.0013 0.01 0.0268
Plasmodium vivax importin-beta 2, putative 0.0028 0.0299 0.6395
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0041 0.0467 1
Echinococcus granulosus ETS transcription factor Elf 2 0.001 0.0072 0.0158
Brugia malayi MH1 domain containing protein 0.0008 0.0042 0.0116
Loa Loa (eye worm) D-ets-2 protein 0.001 0.0072 0.019
Loa Loa (eye worm) TKL/LRRK protein kinase 0.0115 0.1403 0.3733
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0066 0.0066
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0066 0.0175
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0722 0.1357
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0078 0.0935 0.206
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0509 0.0509
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0299 0.0814
Brugia malayi Patched family protein 0.0006 0.0015 0.0042
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0509 0.1353
Echinococcus granulosus FTZ F1 alpha 0.001 0.0066 0.0145
Echinococcus multilocularis tar DNA binding protein 0.0062 0.0722 0.0722
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0292 0.3639 0.968
Loa Loa (eye worm) hypothetical protein 0.0006 0.0015 0.0041
Brugia malayi Patched family protein 0.0006 0.0015 0.0042
Schistosoma mansoni DNA helicase recq1 0.001 0.0064 0.0121
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0331 0.0729
Schistosoma mansoni hypothetical protein 0.0031 0.0331 0.0623
Loa Loa (eye worm) hypothetical protein 0.0006 0.0015 0.0041
Loa Loa (eye worm) patched family protein 0.0006 0.0015 0.0041
Brugia malayi nuclear receptor NHR-88 0.001 0.0066 0.0181
Schistosoma mansoni thyroid hormone receptor 0.001 0.0066 0.0124
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0509 0.1398
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0292 0.3639 0.3639
Echinococcus multilocularis SWI:SNF matrix associated 0.0011 0.0076 0.0076
Echinococcus multilocularis rab protein 3 0.0005 0.0003 0.0003
Trypanosoma cruzi polo-like protein kinase, putative 0.0292 0.3639 1
Echinococcus multilocularis ETS transcription factor Elf 1 0.001 0.0072 0.0072
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0177 0.048
Schistosoma mansoni hypothetical protein 0.0031 0.0331 0.0623
Loa Loa (eye worm) hypothetical protein 0.001 0.0066 0.0175
Loa Loa (eye worm) ATP-dependent DNA helicase 0.001 0.0064 0.0171
Onchocerca volvulus Bile acid receptor homolog 0.001 0.0066 0.0181
Loa Loa (eye worm) hypothetical protein 0.0006 0.0015 0.0041
Brugia malayi Ets-domain containing protein 0.001 0.0072 0.0197
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0177 0.048
Echinococcus granulosus ETS domain containing protein Elk 1 0.001 0.0072 0.0158
Loa Loa (eye worm) Smad1 0.0008 0.0042 0.0112
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0331 0.091
Loa Loa (eye worm) hypothetical protein 0.0006 0.0015 0.0041
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0177 0.0334
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0096 0.1162 0.3191
Echinococcus granulosus axis inhibition protein axin 0.0019 0.0177 0.0391
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.0722 0.192
Echinococcus multilocularis GA binding protein alpha chain 0.0071 0.084 0.084
Echinococcus multilocularis Serine:threonine protein kinase PLK4 0.0229 0.2846 0.2846
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0066 0.0181
Echinococcus multilocularis sterol regulatory element binding protein 0.0041 0.0465 0.0465
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0066 0.0066
Schistosoma mansoni hypothetical protein 0.0005 0.0003 0.0006
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0177 0.048
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0509 0.112
Loa Loa (eye worm) hypothetical protein 0.0005 0.0007 0.0019
Entamoeba histolytica serine/threonine protein kinase, putative 0.0292 0.3639 1
Trichomonas vaginalis ran, putative 0.0021 0.0204 0.0554
Plasmodium falciparum transportin 0.0005 0.0009 0.0141
Giardia lamblia Histone acetyltransferase GCN5 0.0038 0.0423 0.1003
Trichomonas vaginalis DNA helicase recq, putative 0.0024 0.0239 0.0649
Onchocerca volvulus 0.0011 0.0076 0.021
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0066 0.0175
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0722 0.1357
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.0177 0.0177
Trypanosoma cruzi polo-like protein kinase, putative 0.0292 0.3639 1
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0.0177 0.0488
Schistosoma mansoni coup transcription factor 0.001 0.0066 0.0124
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.0177 0.0391
Schistosoma mansoni tyrosine kinase 0.0078 0.0925 0.1739
Echinococcus multilocularis SWI:SNF matrix associated 0.0011 0.0076 0.0076
Echinococcus granulosus leucine rich repeat serine:threonine protein 0.0116 0.1413 0.3112
Schistosoma mansoni patched 1 0.0041 0.0465 0.0875
Brugia malayi Importin beta-1 subunit 0.0028 0.0299 0.0821
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0066 0.0145
Echinococcus granulosus translational activator gcn1 0.0005 0.0009 0.002
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0292 0.3639 1
Entamoeba histolytica hypothetical protein 0.0035 0.0388 0.1061
Schistosoma mansoni blooms syndrome DNA helicase 0.0005 0.0004 0.0007
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0066 0.0181
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0019 0.0177 0.0334
Loa Loa (eye worm) fli-1 protein 0.0215 0.2668 0.7098
Brugia malayi latrophilin 2 splice variant baaae 0.0067 0.0784 0.2154
Brugia malayi RAB, member of RAS oncogene family-like 5 0.0005 0.0003 0.0008
Echinococcus granulosus ATP dependent DNA helicase Q1 0.001 0.0064 0.0141
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.002 0.0197 0.0525
Echinococcus multilocularis protein C ets 2 0.001 0.0072 0.0072
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.0064 0.1303
Toxoplasma gondii HEAT repeat-containing protein 0.0005 0.0009 0.0108
Echinococcus granulosus importin 5 0.0005 0.0009 0.002
Schistosoma mansoni axis inhibition protein axin 0.0019 0.0177 0.0334
Schistosoma mansoni kinase 0.0424 0.532 1
Echinococcus multilocularis ETS domain containing protein Elk 1 0.001 0.0072 0.0072
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0066 0.0181
Echinococcus granulosus Upstream activation factor subunit UAF30 0.0011 0.0076 0.0168
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0066 0.0181
Onchocerca volvulus 0.0005 0.0003 0.0008
Loa Loa (eye worm) hypothetical protein 0.001 0.0066 0.0175
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0019 0.0177 0.0334
Loa Loa (eye worm) hypothetical protein 0.0019 0.0177 0.0472
Entamoeba histolytica hypothetical protein 0.0019 0.0177 0.0484
Brugia malayi Patched protein homolog 1 0.0006 0.0015 0.0042
Loa Loa (eye worm) hypothetical protein 0.0019 0.0177 0.0472
Trichomonas vaginalis CAMK family protein kinase 0.0292 0.3639 1
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0388 0.0728
Loa Loa (eye worm) acetyltransferase 0.0141 0.1728 0.4595
Brugia malayi Nuclear hormone receptor-like 1 0.0005 0.0007 0.0019
Onchocerca volvulus 0.0006 0.0015 0.0042
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0141 0.1728 0.3247
Loa Loa (eye worm) hypothetical protein 0.0006 0.0015 0.0041
Loa Loa (eye worm) hypothetical protein 0.0005 0.0007 0.0019
Leishmania major hypothetical protein, conserved 0.0005 0.0009 0.0016
Brugia malayi Patched family protein 0.0006 0.0015 0.0042
Schistosoma mansoni hypothetical protein 0.0031 0.0331 0.0623
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0722 0.1357
Onchocerca volvulus 0.0006 0.0015 0.0042
Brugia malayi regulator of G-protein signaling rgs-7 0.0019 0.0177 0.0488
Trichomonas vaginalis CAMK family protein kinase 0.0292 0.3639 1
Echinococcus multilocularis beta adrenergic receptor kinase 0.002 0.0197 0.0197
Echinococcus granulosus bloom syndrome protein 0.0024 0.0239 0.0526
Schistosoma mansoni smad1 5 8 and 0.0008 0.0042 0.0079
Loa Loa (eye worm) hypothetical protein 0.0006 0.0015 0.0041
Loa Loa (eye worm) hypothetical protein 0.0041 0.0465 0.1238
Echinococcus multilocularis SWI:SNF matrix associated 0.0011 0.0076 0.0076
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0509 0.0956
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0331 0.091
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.002 0.0197 0.0525
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.002 0.0197 0.0542
Toxoplasma gondii patched family protein 0.0006 0.0015 0.0246
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0071 0.084 0.2233
Schistosoma mansoni hypothetical protein 0.0301 0.376 0.7067
Loa Loa (eye worm) hypothetical protein 0.0006 0.0015 0.0041
Loa Loa (eye worm) hypothetical protein 0.001 0.0064 0.0171
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.0177 0.0177
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0066 0.0124
Schistosoma mansoni hypothetical protein 0.0011 0.0076 0.0144
Echinococcus multilocularis importin 5 0.0005 0.0009 0.0009
Echinococcus multilocularis epidermal growth factor receptor 0.0146 0.1792 0.1792
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0066 0.0145
Brugia malayi Patched family protein 0.0006 0.0015 0.0042
Brugia malayi nuclear receptor RXR 0.0005 0.0007 0.0019
Entamoeba histolytica HEAT repeat domain containing protein 0.0005 0.0009 0.002
Loa Loa (eye worm) hypothetical protein 0.0006 0.0015 0.0041
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0331 0.0881
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0204 0.0204
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.0177 0.0177
Echinococcus multilocularis smad 0.0008 0.0042 0.0042
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0066 0.0175
Echinococcus granulosus histone acetyltransferase KAT2B 0.0137 0.1677 0.3694
Loa Loa (eye worm) hypothetical protein 0.0006 0.0015 0.0041
Brugia malayi Patched family protein 0.0006 0.0015 0.0042
Loa Loa (eye worm) kap beta 3 protein 0.0005 0.0009 0.0024
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0066 0.0145
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.001 0.0064 0.1458
Schistosoma mansoni hypothetical protein 0.004 0.0446 0.0839
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0013 0.01 0.0268
Brugia malayi Bloom's syndrome protein homolog 0.0024 0.0239 0.0657
Schistosoma mansoni ran 0.0021 0.0204 0.0384
Schistosoma mansoni tyrosine kinase 0.0047 0.0533 0.1001
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0066 0.0145
Schistosoma mansoni tyrosine kinase 0.0078 0.0925 0.1739
Loa Loa (eye worm) hypothetical protein 0.0006 0.0015 0.0041
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.001 0.0064 0.0176
Echinococcus granulosus snurportin 1 0.0301 0.376 0.8278
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0005 0.0007 0.0007

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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