Detailed information for compound 689894

Basic information

Technical information
  • TDR Targets ID: 689894
  • Name: ethyl 4-[(4-chlorophenyl)methoxy]-6-oxo-1-phe nylpyridazine-3-carboxylate
  • MW: 384.813 | Formula: C20H17ClN2O4
  • H donors: 0 H acceptors: 2 LogP: 3.97 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOC(=O)c1nn(c2ccccc2)c(=O)cc1OCc1ccc(cc1)Cl
  • InChi: 1S/C20H17ClN2O4/c1-2-26-20(25)19-17(27-13-14-8-10-15(21)11-9-14)12-18(24)23(22-19)16-6-4-3-5-7-16/h3-12H,2,13H2,1H3
  • InChiKey: BDZRYQXZUALNHW-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • ethyl 4-[(4-chlorophenyl)methoxy]-6-oxo-1-phenyl-pyridazine-3-carboxylate
  • 4-[(4-chlorophenyl)methoxy]-6-oxo-1-phenyl-3-pyridazinecarboxylic acid ethyl ester
  • 4-(4-chlorobenzyl)oxy-6-keto-1-phenyl-pyridazine-3-carboxylic acid ethyl ester
  • ZINC05255097

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.0949 0.1545
Onchocerca volvulus Huntingtin homolog 0.0261 0.284 0.3147
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0032 0.0256 0.0255
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.043 0.0504
Schistosoma mansoni survival motor neuron protein 0.0047 0.043 0.0619
Schistosoma mansoni serine/threonine protein kinase 0.0288 0.3139 0.5453
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0035 0.0289 0.0288
Loa Loa (eye worm) cytochrome P450 family protein 0.0041 0.0358 0.0418
Brugia malayi isocitrate dehydrogenase 0.0032 0.0256 0.0301
Schistosoma mansoni hypothetical protein 0.0032 0.0256 0.0308
Onchocerca volvulus Huntingtin homolog 0.0261 0.284 0.3147
Entamoeba histolytica hypothetical protein 0.0072 0.0714 0.1327
Trypanosoma cruzi NIMA-related kinase, putative 0.0288 0.3139 1
Onchocerca volvulus 0.0296 0.3229 0.3614
Loa Loa (eye worm) hypothetical protein 0.0068 0.0669 0.0782
Loa Loa (eye worm) hypothetical protein 0.0032 0.0256 0.0298
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0026 0.0194 0.0192
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0511 0.5655 0.6628
Leishmania major cytochrome p450-like protein 0.0041 0.0358 0.0693
Leishmania major hypothetical protein, conserved 0.0077 0.0768 0.2064
Echinococcus granulosus histone acetyltransferase KAT2B 0.0142 0.1495 0.2628
Loa Loa (eye worm) pigment dispersing factor receptor c 0.01 0.1024 0.1199
Echinococcus multilocularis mothers against decapentaplegic 5 0.0016 0.0083 0.0082
Brugia malayi acetyltransferase, GNAT family protein 0.0146 0.1541 0.1807
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0043 0.0383 0.0025
Brugia malayi Cytochrome P450 family protein 0.0102 0.1053 0.1234
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0054 0.0508 0.0594
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0073 0.0726 0.1926
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0043 0.0383 0.0776
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0032 0.0256 0.2157
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.0256 0.0448
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0073 0.0726 0.1269
Echinococcus granulosus cpg binding protein 0.0031 0.0246 0.043
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0032 0.0256 0.0309
Entamoeba histolytica hypothetical protein 0.0072 0.0714 0.1327
Trichomonas vaginalis alpha-glucosidase, putative 0.0113 0.1177 0.2901
Loa Loa (eye worm) hypothetical protein 0.0026 0.0194 0.0225
Trichomonas vaginalis alpha-glucosidase, putative 0.0113 0.1177 0.2901
Loa Loa (eye worm) hypothetical protein 0.0025 0.0183 0.0212
Loa Loa (eye worm) inositol-1 0.0073 0.0726 0.085
Loa Loa (eye worm) hypothetical protein 0.0054 0.0508 0.0594
Brugia malayi Inositol-1 0.0073 0.0726 0.0851
Echinococcus granulosus inositol monophosphatase 1 0.0073 0.0726 0.1275
Echinococcus granulosus neutral alpha glucosidase AB 0.0113 0.1177 0.2068
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0073 0.0726 0.1269
Schistosoma mansoni cpg binding protein 0.0031 0.0246 0.029
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0113 0.1177 0.2985
Echinococcus multilocularis GPCR, family 2 0.0032 0.0256 0.0255
Plasmodium falciparum NIMA related kinase 2 0.0288 0.3139 1
Toxoplasma gondii NEK kinase 0.0288 0.3139 1
Brugia malayi hypothetical protein 0.0261 0.284 0.3329
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0113 0.1177 0.1378
Brugia malayi CXXC zinc finger family protein 0.0029 0.0227 0.0266
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.0256 0.0255
Plasmodium falciparum NIMA related kinase 4 0.0288 0.3139 1
Echinococcus granulosus Smad4 0.0016 0.0083 0.0144
Echinococcus granulosus lamin 0.0054 0.0508 0.0892
Loa Loa (eye worm) hypothetical protein 0.0767 0.8532 1
Echinococcus granulosus lamin dm0 0.0054 0.0508 0.0892
Trypanosoma brucei cytochrome P450, putative 0.0041 0.0358 0.0693
Schistosoma mansoni hypothetical protein 0.0072 0.0714 0.1125
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0072 0.0714 0.0712
Brugia malayi Latrophilin receptor protein 2 0.0032 0.0256 0.03
Echinococcus multilocularis neutral alpha glucosidase AB 0.0113 0.1177 0.1176
Onchocerca volvulus 0.0054 0.0508 0.0339
Brugia malayi cytoplasmic intermediate filament protein 0.0029 0.0226 0.0265
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.0949 0.1545
Trypanosoma cruzi PAB1-binding protein , putative 0.0077 0.0768 0.2064
Loa Loa (eye worm) hypothetical protein 0.0261 0.284 0.3328
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.0256 0.0448
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0032 0.0256 0.0353
Brugia malayi Intermediate filament tail domain containing protein 0.0054 0.0508 0.0596
Brugia malayi Isocitrate dehydrogenase 0.0032 0.0256 0.0301
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.0256 0.0255
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0113 0.1177 0.2901
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.0593 0.0911
Trypanosoma cruzi hypothetical protein, conserved 0.0113 0.1177 0.3435
Schistosoma mansoni hypothetical protein 0.0035 0.0289 0.0368
Onchocerca volvulus 0.0047 0.043 0.0245
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0042 0.0376 0.0752
Loa Loa (eye worm) nuclear factor I 0.0009 0.0001 0.0000087179
Brugia malayi hypothetical protein 0.005 0.046 0.0539
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.0256 0.03
Brugia malayi Smad1 0.0016 0.0083 0.0097
Trichomonas vaginalis sucrase-isomaltase, putative 0.0113 0.1177 0.2901
Toxoplasma gondii LsmAD domain-containing protein 0.0077 0.0768 0.2064
Schistosoma mansoni hypothetical protein 0.0068 0.0669 0.1045
Trypanosoma brucei glycosyl hydrolase-like protein 0.0042 0.0376 0.0752
Brugia malayi MH1 domain containing protein 0.0016 0.0083 0.0097
Trypanosoma cruzi hypothetical protein, conserved 0.0113 0.1177 0.3435
Echinococcus multilocularis survival motor neuron protein 1 0.0231 0.2498 0.2497
Trypanosoma cruzi PAB1-binding protein , putative 0.0077 0.0768 0.2064
Plasmodium vivax serine/threonine-protein kinase NEK4, putative 0.0288 0.3139 1
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0032 0.0256 0.0353
Leishmania major glycosyl hydrolase-like protein 0.0042 0.0376 0.0752
Loa Loa (eye worm) hypothetical protein 0.0261 0.284 0.3328
Schistosoma mansoni inositol monophosphatase 0.0073 0.0726 0.1148
Schistosoma mansoni alpha-glucosidase 0.044 0.4854 0.8514
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0093 0.0949 0.1666
Plasmodium vivax serine/threonine-protein kinase Nek1, putative 0.0288 0.3139 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0093 0.0949 0.0947
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0073 0.0726 1
Trypanosoma brucei NIMA-related protein kinase 0.0288 0.3139 1
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0146 0.1541 0.154
Echinococcus granulosus mothers against decapentaplegic 5 0.0016 0.0083 0.0144
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0042 0.0376 0.0119
Toxoplasma gondii isocitrate dehydrogenase 0.0032 0.0256 0.0353
Echinococcus multilocularis lysosomal alpha glucosidase 0.0511 0.5655 0.5654
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0073 0.0726 0.1926
Plasmodium falciparum histone acetyltransferase GCN5 0.0039 0.0343 0.0299
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0041 0.0358 0.3598
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0042 0.0376 0.0179
Schistosoma mansoni hypothetical protein 0.0032 0.0256 0.0308
Brugia malayi hypothetical protein 0.0231 0.2498 0.2928
Brugia malayi MH1 domain containing protein 0.0016 0.0083 0.0097
Echinococcus multilocularis lysosomal alpha glucosidase 0.0511 0.5655 0.5654
Schistosoma mansoni transcription factor LCR-F1 0.0072 0.0714 0.1125
Echinococcus multilocularis smad 0.0016 0.0083 0.0082
Brugia malayi Cytochrome P450 family protein 0.0022 0.0151 0.0177
Echinococcus granulosus intermediate filament protein 0.0054 0.0508 0.0892
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0073 0.0726 0.1926
Trypanosoma cruzi cytochrome P450, putative 0.0041 0.0358 0.0693
Schistosoma mansoni hypothetical protein 0.0047 0.043 0.0619
Schistosoma mansoni lamin 0.0054 0.0508 0.0759
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0073 0.0726 0.1926
Leishmania major serine/threonine-protein kinase, putative 0.0288 0.3139 1
Brugia malayi hypothetical protein 0.0077 0.0768 0.09
Schistosoma mansoni inositol monophosphatase 0.0073 0.0726 0.1148
Trichomonas vaginalis bromodomain-containing protein, putative 0.0043 0.0383 0.0025
Entamoeba histolytica serine/threonine protein kinase, putative 0.0288 0.3139 1
Brugia malayi Cytochrome P450 family protein 0.0041 0.0358 0.042
Schistosoma mansoni alpha-glucosidase 0.044 0.4854 0.8514
Entamoeba histolytica hypothetical protein 0.0072 0.0714 0.1327
Loa Loa (eye worm) hypothetical protein 0.0042 0.0376 0.0439
Schistosoma mansoni hypothetical protein 0.0022 0.0151 0.0121
Loa Loa (eye worm) isocitrate dehydrogenase 0.0032 0.0256 0.0299
Schistosoma mansoni hypothetical protein 0.0032 0.0256 0.0308
Echinococcus granulosus TGF beta signal transducer SmadC 0.0016 0.0083 0.0144
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0029 0.0226 0.0263
Brugia malayi Glycosyl hydrolases family 31 protein 0.0042 0.0376 0.044
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0073 0.0726 0.5
Echinococcus multilocularis inositol monophosphatase 1 0.0073 0.0726 0.0725
Echinococcus granulosus GPCR family 2 0.0032 0.0256 0.0448
Brugia malayi MH1 domain containing protein 0.0009 0.0001 0.0002
Echinococcus multilocularis Smad4 0.0016 0.0083 0.0082
Brugia malayi Glycosyl hydrolases family 31 protein 0.0113 0.1177 0.138
Brugia malayi Calcitonin receptor-like protein seb-1 0.01 0.1024 0.1201
Echinococcus multilocularis lamin dm0 0.0054 0.0508 0.0507
Echinococcus multilocularis 0.0022 0.0151 0.015
Echinococcus granulosus histone acetyltransferase KAT2B 0.0043 0.0383 0.0671
Loa Loa (eye worm) MH2 domain-containing protein 0.0016 0.0083 0.0096
Toxoplasma gondii NEK kinase 0.0288 0.3139 1
Schistosoma mansoni cpg binding protein 0.0029 0.0227 0.0257
Schistosoma mansoni hypothetical protein 0.0514 0.5686 1
Trichomonas vaginalis CAMK family protein kinase 0.0288 0.3139 1
Echinococcus granulosus serine:threonine protein kinase Nek1 0.0281 0.3056 0.5374
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.01 0.1024 0.1201
Brugia malayi hypothetical protein 0.0767 0.8532 1
Trichomonas vaginalis CAMK family protein kinase 0.0288 0.3139 1
Trichomonas vaginalis CAMK family protein kinase 0.0288 0.3139 1
Echinococcus multilocularis serine:threonine protein kinase Nek1 0.0281 0.3056 0.3055
Loa Loa (eye worm) hypothetical protein 0.0053 0.0497 0.0581
Trypanosoma cruzi Serine/threonine-protein kinase NEK16, putative 0.0288 0.3139 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.0256 0.0255
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0016 0.0083 0.0082
Brugia malayi Glycosyl hydrolases family 31 protein 0.0511 0.5655 0.6628
Onchocerca volvulus 0.0767 0.8532 1
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0146 0.1541 0.2602
Schistosoma mansoni hypothetical protein 0.0514 0.5686 1
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0043 0.0383 0.0776
Schistosoma mansoni hypothetical protein 0.0414 0.4555 0.798
Entamoeba histolytica hypothetical protein 0.0072 0.0714 0.1327
Loa Loa (eye worm) cytochrome P450 0.0022 0.0151 0.0175
Loa Loa (eye worm) MH1 domain-containing protein 0.0016 0.0083 0.0096
Echinococcus granulosus lysosomal alpha glucosidase 0.0511 0.5655 0.9945
Trypanosoma brucei PAB1-binding protein , putative 0.0077 0.0768 0.2064
Brugia malayi MH2 domain containing protein 0.0016 0.0083 0.0097
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.0256 0.0298
Trichomonas vaginalis CAMK family protein kinase 0.0288 0.3139 1
Echinococcus granulosus smad 0.0016 0.0083 0.0144
Plasmodium falciparum ataxin-2 like protein, putative 0.0077 0.0768 0.1774
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0042 0.0376 0.0752
Trypanosoma cruzi Serine/threonine-protein kinase NEK11, putative 0.0288 0.3139 1
Echinococcus multilocularis cpg binding protein 0.0031 0.0246 0.0244
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0093 0.0949 0.1112
Trypanosoma cruzi cytochrome P450, putative 0.0041 0.0358 0.0693
Trypanosoma cruzi protein kinase, putative 0.0281 0.3056 0.9724
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0043 0.0383 0.0438
Loa Loa (eye worm) intermediate filament protein 0.0054 0.0508 0.0594
Trypanosoma cruzi Serine/threonine-protein kinase NEK11, putative 0.0288 0.3139 1
Echinococcus multilocularis isocitrate dehydrogenase 0.0032 0.0256 0.0255
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0113 0.1177 0.2901
Giardia lamblia Kinase, NEK 0.0288 0.3139 1
Schistosoma mansoni alpha glucosidase 0.0113 0.1177 0.1953
Leishmania major protein kinase, putative 0.0288 0.3139 1
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0032 0.0256 0.0353
Toxoplasma gondii NEK kinase 0.0288 0.3139 1
Toxoplasma gondii histone lysine methyltransferase SET1 0.0059 0.056 0.1367
Echinococcus granulosus survival motor neuron protein 1 0.0231 0.2498 0.4392
Brugia malayi cytochrome P450 0.0022 0.0151 0.0177
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0066 0.064 1
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0026 0.0194 0.0338
Echinococcus multilocularis geminin 0.0514 0.5686 0.5686
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0113 0.1177 0.2985
Loa Loa (eye worm) acetyltransferase 0.0146 0.1541 0.1805
Loa Loa (eye worm) hypothetical protein 0.0231 0.2498 0.2927
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0073 0.0726 0.1926
Schistosoma mansoni cpg binding protein 0.0031 0.0246 0.029
Brugia malayi MH2 domain containing protein 0.0239 0.2585 0.303
Loa Loa (eye worm) cytochrome P450 family protein 0.0041 0.0358 0.0418
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0032 0.0256 0.0449
Echinococcus multilocularis dnaJ subfamily B 0.0414 0.4555 0.4554
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.0256 0.0255
Toxoplasma gondii isocitrate dehydrogenase 0.0032 0.0256 0.0353
Echinococcus granulosus geminin 0.0514 0.5686 1
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0113 0.1177 0.3435
Loa Loa (eye worm) MH2 domain-containing protein 0.0239 0.2585 0.3029
Loa Loa (eye worm) hypothetical protein 0.0025 0.0183 0.0212
Trypanosoma brucei Serine/threonine-protein kinase NEK16, putative 0.0288 0.3139 1
Schistosoma mansoni cytochrome P450 0.0022 0.0151 0.0121
Brugia malayi latrophilin 2 splice variant baaae 0.0068 0.0669 0.0784
Brugia malayi MH1 domain containing protein 0.0009 0.0001 0.0002
Plasmodium vivax ataxin-2 like protein, putative 0.0077 0.0768 0.1774
Loa Loa (eye worm) hypothetical protein 0.0009 0.0001 0.0000087179
Leishmania major protein kinase, putative,serine/threonine-protein kinase Nek1, putative 0.0288 0.3139 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0077 0.0768 0.1774
Trichomonas vaginalis alpha-glucosidase, putative 0.0113 0.1177 0.2901
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.0949 0.1545
Echinococcus multilocularis musashi 0.0054 0.0508 0.0507
Trichomonas vaginalis STE family protein kinase 0.0288 0.3139 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0093 0.0949 0.1666
Loa Loa (eye worm) Smad1 0.0016 0.0083 0.0096
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0066 0.064 1
Loa Loa (eye worm) CYP4Cod1 0.0041 0.0358 0.0418
Leishmania major alpha glucosidase II subunit, putative 0.0113 0.1177 0.3435
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0072 0.0714 0.1253
Schistosoma mansoni lamin 0.0054 0.0508 0.0759
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0035 0.0289 0.0507
Brugia malayi hypothetical protein 0.0072 0.0714 0.0837
Echinococcus granulosus dnaJ subfamily B 0.0414 0.4555 0.8009
Trichomonas vaginalis inositol monophosphatase, putative 0.0073 0.0726 0.1269
Schistosoma mansoni hypothetical protein 0.0032 0.0256 0.0308
Trichomonas vaginalis alpha-glucosidase, putative 0.0113 0.1177 0.2901
Loa Loa (eye worm) hypothetical protein 0.01 0.1024 0.1199
Loa Loa (eye worm) hypothetical protein 0.0018 0.0107 0.0124
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0093 0.0949 0.0947
Brugia malayi MH2 domain containing protein 0.0016 0.0083 0.0097
Echinococcus granulosus cytochrome P450 2K1 0.0022 0.0151 0.0263
Brugia malayi Cytochrome P450 family protein 0.0041 0.0358 0.042
Schistosoma mansoni intermediate filament proteins 0.0054 0.0508 0.0759
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.0256 0.0255
Echinococcus multilocularis lamin 0.0054 0.0508 0.0507
Trypanosoma brucei glucosidase, putative 0.0113 0.1177 0.3435
Loa Loa (eye worm) hypothetical protein 0.0077 0.0768 0.0898
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0073 0.0726 0.1372
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0032 0.0256 0.0353
Loa Loa (eye worm) cytochrome P450 family protein 0.0102 0.1053 0.1232
Loa Loa (eye worm) transcription factor SMAD2 0.0239 0.2585 0.3029
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0032 0.0256 0.0353
Trichomonas vaginalis alpha-glucosidase, putative 0.0113 0.1177 0.2901
Trypanosoma brucei Serine/threonine-protein kinase NEK11, putative 0.0288 0.3139 1
Onchocerca volvulus 0.0054 0.0508 0.0339
Brugia malayi intermediate filament protein 0.0054 0.0508 0.0596
Trichomonas vaginalis maltase-glucoamylase, putative 0.0113 0.1177 0.2901
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0093 0.0949 0.111
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0227 0.0265

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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