Detailed information for compound 69357

Basic information

Technical information
  • TDR Targets ID: 69357
  • Name: 2-(2-propan-2-yl-1H-imidazol-5-yl)ethanamine
  • MW: 153.225 | Formula: C8H15N3
  • H donors: 2 H acceptors: 1 LogP: 0.58 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: NCCc1nc([nH]c1)C(C)C
  • InChi: 1S/C8H15N3/c1-6(2)8-10-5-7(11-8)3-4-9/h5-6H,3-4,9H2,1-2H3,(H,10,11)
  • InChiKey: VVACTURLJWWFGU-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-(2-isopropyl-1H-imidazol-5-yl)ethanamine
  • 2-(2-isopropyl-1H-imidazol-5-yl)ethylamine
  • 2-(2-propan-2-yl-3H-imidazol-4-yl)ethanamine
  • 2-(2-isopropyl-3H-imidazol-4-yl)ethanamine
  • 2-(2-isopropyl-3H-imidazol-4-yl)ethylamine

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0255783 0.0163327 0.0287172
Echinococcus granulosus sphingomyelin synthase protein 1 0.0253723 0.0161159 0.028336
Echinococcus granulosus fetal alzheimer antigen falz 0.0204082 0.010889 0.0191457
Echinococcus multilocularis Sterile alpha motif SAM 0.0253723 0.0161159 0.028336
Brugia malayi coiled-coil like protein 1 0.0253723 0.0161159 0.0274305
Schistosoma mansoni bromodomain containing protein 0.0204082 0.010889 0.0106553
Schistosoma mansoni lar interacting protein (lip)-related protein 0.0253723 0.0161159 0.0158834
Brugia malayi CHD4 protein 0.0306992 0.0217247 0.0369772
Plasmodium falciparum EELM2 domain-containing protein, putative 0.0204082 0.010889 0.508317
Loa Loa (eye worm) hypothetical protein 0.010291 0.000236219 0.000402064
Schistosoma mansoni dpf3 0.0204082 0.010889 0.0106553
Trypanosoma brucei Present in the outer mitochondrial membrane proteome 24 0.0253723 0.0161159 1
Schistosoma mansoni SET domain protein 0.0204082 0.010889 0.0106553
Loa Loa (eye worm) hypothetical protein 0.0253723 0.0161159 0.0274305
Trichomonas vaginalis conserved hypothetical protein 0.0204082 0.010889 0.670843
Onchocerca volvulus 0.0428184 0.0344856 0.0586972
Plasmodium falciparum JmjC domain-containing protein, putative 0.0301943 0.0211932 1
Schistosoma mansoni myelin transcription factor 1 myt1 0.129464 0.125718 0.125512
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0204082 0.010889 0.0191457
Schistosoma mansoni hypothetical protein 0.0253723 0.0161159 0.0158834
Trichomonas vaginalis c2h2 zinc finger protein, putative 0.0253723 0.0161159 1
Loa Loa (eye worm) hypothetical protein 0.0253723 0.0161159 0.0274305
Brugia malayi SET domain containing protein 0.0204082 0.010889 0.0185339
Echinococcus multilocularis sterile alpha and tir motif containing protein 0.0253723 0.0161159 0.028336
Schistosoma mansoni hypothetical protein 0.0204082 0.010889 0.0106553
Echinococcus granulosus sterile alpha and tir motif containing protein 0.0253723 0.0161159 0.028336
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.033785 0.0249739 0.653183
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0428184 0.0344856 0.0586972
Schistosoma mansoni fyve-containing 0.0204082 0.010889 0.0106553
Loa Loa (eye worm) hypothetical protein 0.0204082 0.010889 0.0185339
Echinococcus multilocularis histone acetyltransferase MYST2 0.129464 0.125718 0.221046
Trichomonas vaginalis conserved hypothetical protein 0.0253723 0.0161159 1
Brugia malayi hypothetical protein 0.0253723 0.0161159 0.0274305
Onchocerca volvulus 0.010291 0.000236219 0.000402064
Echinococcus granulosus cpg binding protein 0.0204082 0.010889 0.0191457
Echinococcus granulosus remodeling and spacing factor 1 0.0204082 0.010889 0.0191457
Plasmodium falciparum SNF2 helicase, putative 0.0204082 0.010889 0.508317
Loa Loa (eye worm) hypothetical protein 0.0428184 0.0344856 0.0586972
Echinococcus granulosus zinc finger protein 0.0204082 0.010889 0.0191457
Echinococcus granulosus polycomb protein SCMH1 0.305483 0.311054 0.546915
Echinococcus multilocularis SAM and MBT domain containing protein 0.472755 0.487182 0.856593
Trichomonas vaginalis conserved hypothetical protein 0.0204082 0.010889 0.670843
Brugia malayi jmjC domain containing protein 0.0255783 0.0163327 0.0277996
Trichomonas vaginalis cgi-62, putative 0.0253723 0.0161159 1
Brugia malayi sterile alpha and TIR motif containing protein 1 isoform a 0.0253723 0.0161159 0.0274305
Echinococcus multilocularis sphingomyelin synthase protein 1 0.0253723 0.0161159 0.028336
Echinococcus multilocularis Chromobox protein 3 0.010291 0.000236219 0.000415335
Loa Loa (eye worm) hypothetical protein 0.010291 0.000236219 0.000402064
Echinococcus multilocularis lysine specific demethylase 5A 0.0802524 0.0739011 0.129937
Schistosoma mansoni myst-related protein 0.0204082 0.010889 0.0106553
Plasmodium vivax protein kinase, putative 0.0253723 0.0161159 0.757729
Brugia malayi PHD-finger family protein 0.0204082 0.010889 0.0185339
Loa Loa (eye worm) acetylcholinesterase 1 0.033946 0.0251435 0.0427963
Brugia malayi cask-interacting protein 2 0.0253723 0.0161159 0.0274305
Schistosoma mansoni jumonji/arid domain-containing protein 0.100661 0.0953897 0.0951759
Onchocerca volvulus 0.0253723 0.0161159 0.0274305
Brugia malayi PHD-finger family protein 0.0204082 0.010889 0.0185339
Brugia malayi hypothetical protein 0.010291 0.000236219 0.000402064
Brugia malayi mbt repeat family protein 0.328788 0.335593 0.571206
Schistosoma mansoni lip-related protein (liprin) alpha 0.0253723 0.0161159 0.0158834
Trypanosoma brucei SAM domain (Sterile alpha motif), putative 0.0253723 0.0161159 1
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.129464 0.125718 0.221046
Onchocerca volvulus 0.010291 0.000236219 0.000402064
Loa Loa (eye worm) hypothetical protein 0.0253723 0.0161159 0.0274305
Brugia malayi Heterochromatin protein 1 0.010291 0.000236219 0.000402064
Loa Loa (eye worm) PHD-finger family protein 0.0204082 0.010889 0.0185339
Echinococcus granulosus phd finger protein 12 0.0204082 0.010889 0.0191457
Onchocerca volvulus 0.0253723 0.0161159 0.0274305
Echinococcus multilocularis PHD and RING finger domain containing protein 1 0.0204082 0.010889 0.0191457
Loa Loa (eye worm) hypothetical protein 0.129464 0.125718 0.213982
Echinococcus multilocularis cpg binding protein 0.0204082 0.010889 0.0191457
Echinococcus granulosus lysine specific demethylase 5B 0.0204082 0.010889 0.0191457
Brugia malayi Carboxylesterase family protein 0.033946 0.0251435 0.0427963
Schistosoma mansoni jumonji/arid domain-containing protein 0.100661 0.0953897 0.0951759
Schistosoma mansoni chromobox protein 0.197031 0.196862 0.196672
Echinococcus granulosus polyhomeotic proximal chromatin protein 0.0253723 0.0161159 0.028336
Trichomonas vaginalis conserved hypothetical protein 0.0204082 0.010889 0.670843
Echinococcus multilocularis histone acetyltransferase myst3 0.0457805 0.0376044 0.0661184
Loa Loa (eye worm) hypothetical protein 0.010291 0.000236219 0.000402064
Loa Loa (eye worm) hypothetical protein 0.033946 0.0251435 0.0427963
Echinococcus multilocularis lysine specific demethylase 5B 0.0204082 0.010889 0.0191457
Schistosoma mansoni sex comb on midleg homolog 0.305483 0.311054 0.310892
Schistosoma mansoni cpg binding protein 0.0204082 0.010889 0.0106553
Schistosoma mansoni sodium/chloride dependent transporter 0.0428184 0.0344856 0.0342574
Loa Loa (eye worm) heterochromatin protein 1 0.010291 0.000236219 0.000402064
Toxoplasma gondii PHD-finger domain-containing protein 0.0204082 0.010889 0.28128
Loa Loa (eye worm) carboxylesterase 0.033946 0.0251435 0.0427963
Echinococcus multilocularis acetylcholinesterase 0.033946 0.0251435 0.0442089
Echinococcus multilocularis acetylcholinesterase 0.033946 0.0251435 0.0442089
Echinococcus multilocularis serotonin transporter 0.0428184 0.0344856 0.0606346
Echinococcus multilocularis polyhomeotic proximal chromatin protein 0.0253723 0.0161159 0.028336
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0204082 0.010889 0.0106553
Trypanosoma cruzi Kinesin-13 5, putative 0.0253723 0.0161159 1
Echinococcus multilocularis chromobox protein 1 0.010291 0.000236219 0.000415335
Echinococcus granulosus endonuclease exonuclease phosphatase 0.550217 0.568744 1
Trichomonas vaginalis conserved hypothetical protein 0.0204082 0.010889 0.670843
Brugia malayi hypothetical protein 0.0253723 0.0161159 0.0274305
Echinococcus multilocularis histone acetyltransferase myst4 0.0204082 0.010889 0.0191457
Onchocerca volvulus 0.0253723 0.0161159 0.0274305
Schistosoma mansoni bromodomain containing protein 0.0204082 0.010889 0.0106553
Brugia malayi Protein cec-1. 0.010291 0.000236219 0.000402064
Echinococcus granulosus Chromo domain 0.010291 0.000236219 0.000415335
Brugia malayi SET domain containing protein 0.010291 0.000236219 0.000402064
Loa Loa (eye worm) hypothetical protein 0.010291 0.000236219 0.000402064
Schistosoma mansoni hypothetical protein 0.0204082 0.010889 0.0106553
Schistosoma mansoni hypothetical protein 0.0204082 0.010889 0.0106553
Brugia malayi PHD-finger family protein 0.0204082 0.010889 0.0185339
Loa Loa (eye worm) hypothetical protein 0.0204082 0.010889 0.0185339
Echinococcus multilocularis phd finger protein 10 0.0204082 0.010889 0.0191457
Loa Loa (eye worm) PHD-finger family protein 0.0204082 0.010889 0.0185339
Loa Loa (eye worm) hypothetical protein 0.0204082 0.010889 0.0185339
Echinococcus granulosus chromobox protein 1 0.010291 0.000236219 0.000415335
Echinococcus granulosus histone acetyltransferase MYST2 0.129464 0.125718 0.221046
Loa Loa (eye worm) hypothetical protein 0.0204082 0.010889 0.0185339
Toxoplasma gondii hypothetical protein 0.0269641 0.017792 0.463549
Echinococcus granulosus liprin alpha 2 0.0253723 0.0161159 0.028336
Brugia malayi PHD-finger family protein 0.0204082 0.010889 0.0185339
Brugia malayi jmjC domain containing protein 0.14692 0.144098 0.245266
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.123826 0.119781 0.210607
Brugia malayi mbt repeat family protein 0.568046 0.587517 1
Schistosoma mansoni phd finger protein 0.0457805 0.0376044 0.037377
Plasmodium vivax hypothetical protein, conserved 0.0204082 0.010889 0.508317
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.129464 0.125718 0.213982
Schistosoma mansoni myst histone acetyltransferase 0.0204082 0.010889 0.0106553
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.550217 0.568744 1
Treponema pallidum sodium- and chloride- dependent transporter 0.0428184 0.0344856 0.5
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.123826 0.119781 0.210607
Echinococcus granulosus Sterile alpha motif type 0.0253723 0.0161159 0.028336
Loa Loa (eye worm) hypothetical protein 0.0204082 0.010889 0.0185339
Echinococcus multilocularis polycomb protein SCMH1 0.305483 0.311054 0.546915
Schistosoma mansoni Protein aveugle 0.0253723 0.0161159 0.0158834
Echinococcus multilocularis Chromo domain 0.010291 0.000236219 0.000415335
Loa Loa (eye worm) hypothetical protein 0.0204082 0.010889 0.0185339
Echinococcus granulosus SAM and MBT domain containing protein 0.472755 0.487182 0.856593
Echinococcus granulosus liprin alpha 2 0.0253723 0.0161159 0.028336
Loa Loa (eye worm) hypothetical protein 0.0204082 0.010889 0.0185339
Entamoeba histolytica hypothetical protein 0.0204082 0.010889 1
Brugia malayi M-phase phosphoprotein, mpp8 0.010291 0.000236219 0.000402064
Loa Loa (eye worm) hypothetical protein 0.568046 0.587517 1
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.472755 0.487182 0.487061
Loa Loa (eye worm) F/Y-rich family protein 0.0204082 0.010889 0.0185339
Onchocerca volvulus 0.010291 0.000236219 0.000402064
Echinococcus multilocularis carboxylesterase 5A 0.033946 0.0251435 0.0442089
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.568046 0.587517 1
Brugia malayi Carboxylesterase family protein 0.033946 0.0251435 0.0427963
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0142135 0.00436638 0.109054
Brugia malayi Bromodomain containing protein 0.0204082 0.010889 0.0185339
Echinococcus multilocularis zinc finger protein 0.0204082 0.010889 0.0191457
Echinococcus granulosus tumor suppressor p53 binding protein 1 0.434852 0.447272 0.78642
Loa Loa (eye worm) hypothetical protein 0.134323 0.130834 0.222689
Loa Loa (eye worm) mbt repeat family protein 0.328788 0.335593 0.571206
Echinococcus granulosus polyhomeotic protein 2 0.0253723 0.0161159 0.028336
Echinococcus multilocularis liprin alpha 2 0.0253723 0.0161159 0.028336
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.129464 0.125718 0.221046
Loa Loa (eye worm) hypothetical protein 0.0253723 0.0161159 0.0274305
Onchocerca volvulus 0.0204082 0.010889 0.0185339
Schistosoma mansoni hypothetical protein 0.0204082 0.010889 0.0106553
Onchocerca volvulus 0.0204082 0.010889 0.0185339
Echinococcus granulosus serotonin transporter 0.0428184 0.0344856 0.0606346
Brugia malayi chromobox protein homolog 3 0.010291 0.000236219 0.000402064
Schistosoma mansoni zinc finger protein 0.0204082 0.010889 0.0106553
Loa Loa (eye worm) hypothetical protein 0.0253723 0.0161159 0.0274305
Brugia malayi F/Y-rich N-terminus family protein 0.0204082 0.010889 0.0185339
Plasmodium vivax SNF2 family N-terminal domain containing protein 0.0204082 0.010889 0.508317
Trypanosoma cruzi Kinesin-13 5, putative 0.0253723 0.0161159 1
Echinococcus multilocularis pdz domain containing protein 0.0253723 0.0161159 0.028336
Echinococcus granulosus lysine specific demethylase 5A 0.100661 0.0953897 0.16772
Trypanosoma cruzi hypothetical protein 0.0253723 0.0161159 1
Loa Loa (eye worm) hypothetical protein 0.010291 0.000236219 0.000402064
Schistosoma mansoni polyhomeotic 0.0253723 0.0161159 0.0158834
Echinococcus multilocularis tumor suppressor p53 binding protein 1 0.434852 0.447272 0.78642
Brugia malayi Bromodomain associated family protein 0.0204082 0.010889 0.0185339
Schistosoma mansoni requim req/dpf2 0.0204082 0.010889 0.0106553
Onchocerca volvulus 0.0253723 0.0161159 0.0274305
Onchocerca volvulus 0.0204082 0.010889 0.0185339
Loa Loa (eye worm) hypothetical protein 0.0204082 0.010889 0.0185339
Toxoplasma gondii PLU-1 family protein 0.0462594 0.0381087 1
Echinococcus multilocularis uro adherence factor A 0.0204082 0.010889 0.0191457
Onchocerca volvulus 0.0204082 0.010889 0.0185339
Onchocerca volvulus 0.35416 0.362308 0.616678
Brugia malayi Sphingomyelin synthase-related 1 0.0253723 0.0161159 0.0274305
Onchocerca volvulus 0.0253723 0.0161159 0.0274305
Loa Loa (eye worm) helicase 0.010291 0.000236219 0.000402064
Echinococcus multilocularis remodeling and spacing factor 1 0.0204082 0.010889 0.0191457
Loa Loa (eye worm) serotonin transporter b 0.0428184 0.0344856 0.0586972
Schistosoma mansoni zinc finger protein 0.0204082 0.010889 0.0106553
Schistosoma mansoni jumonji domain containing protein 0.0255783 0.0163327 0.0161003
Echinococcus granulosus phd finger protein 10 0.0204082 0.010889 0.0191457
Trichomonas vaginalis inhibitor of growth, putative 0.0204082 0.010889 0.670843
Brugia malayi hypothetical protein 0.0204082 0.010889 0.0185339
Brugia malayi Liprin-alpha 2 0.0253723 0.0161159 0.0274305
Onchocerca volvulus 0.0253723 0.0161159 0.0274305
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0204082 0.010889 0.0191457
Loa Loa (eye worm) hypothetical protein 0.010291 0.000236219 0.000402064
Echinococcus multilocularis Sterile alpha motif type 0.0253723 0.0161159 0.028336
Toxoplasma gondii PHD-finger domain-containing protein 0.0204082 0.010889 0.28128
Brugia malayi bicaudal-C 0.0253723 0.0161159 0.0274305
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0204082 0.010889 0.0191457
Loa Loa (eye worm) CHromoDomain protein family member 0.0306992 0.0217247 0.0369772
Echinococcus granulosus PHD finger protein 14 0.0204082 0.010889 0.0191457
Echinococcus multilocularis liprin alpha 2 0.0253723 0.0161159 0.028336
Schistosoma mansoni cpg binding protein 0.0204082 0.010889 0.0106553
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0306992 0.0217247 0.0381978
Schistosoma mansoni hypothetical protein 0.0253723 0.0161159 0.0158834
Echinococcus multilocularis PHD finger protein 14 0.0204082 0.010889 0.0191457
Onchocerca volvulus Heterochromatin protein 1 homolog 0.010291 0.000236219 0.000402064
Toxoplasma gondii PHD-finger domain-containing protein 0.0204082 0.010889 0.28128
Echinococcus multilocularis polyhomeotic protein 2 0.0253723 0.0161159 0.028336
Loa Loa (eye worm) hypothetical protein 0.0204082 0.010889 0.0185339
Loa Loa (eye worm) MBCTL1 0.129464 0.125718 0.213982
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0204082 0.010889 0.0191457
Loa Loa (eye worm) solute carrier family 6 member 4 0.0428184 0.0344856 0.0586972
Loa Loa (eye worm) hypothetical protein 0.0253723 0.0161159 0.0274305
Schistosoma mansoni hepatitis B virus X associated protein hbxa 0.0204082 0.010889 0.0106553
Echinococcus multilocularis phd finger protein 12 0.0204082 0.010889 0.0191457
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0306992 0.0217247 0.0381978
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0428184 0.0344856 0.0342574
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.010291 0.000236219 0.000415335
Giardia lamblia Kinesin-13 0.0253723 0.0161159 0.5
Schistosoma mansoni DNAj-like protein 0.0253723 0.0161159 0.0158834
Echinococcus granulosus uro adherence factor A 0.0204082 0.010889 0.0191457
Onchocerca volvulus 0.0204082 0.010889 0.0185339
Schistosoma mansoni zinc finger protein 0.0204082 0.010889 0.0106553
Loa Loa (eye worm) hypothetical protein 0.033946 0.0251435 0.0427963
Echinococcus granulosus TAF3 RNA polymerase II TATA box binding protein 0.0204082 0.010889 0.0191457
Plasmodium vivax JmjC domain containing protein 0.0301943 0.0211932 1
Loa Loa (eye worm) hypothetical protein 0.0204082 0.010889 0.0185339
Giardia lamblia Giardia trophozoite antigen GTA-1 0.0253723 0.0161159 0.5
Brugia malayi PHD-finger family protein 0.0204082 0.010889 0.0185339
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0306992 0.0217247 0.0214936
Echinococcus granulosus histone acetyltransferase myst3 0.0457805 0.0376044 0.0661184
Loa Loa (eye worm) hypothetical protein 0.0253723 0.0161159 0.0274305
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0255783 0.0163327 0.0287172
Loa Loa (eye worm) hypothetical protein 0.0253723 0.0161159 0.0274305
Echinococcus granulosus PHD and RING finger domain containing protein 1 0.0204082 0.010889 0.0191457
Onchocerca volvulus Heterochromatin protein 1 homolog 0.010291 0.000236219 0.000402064
Echinococcus granulosus histone acetyltransferase myst4 0.0204082 0.010889 0.0191457
Echinococcus multilocularis chromobox protein 2 0.197031 0.196862 0.346135
Schistosoma mansoni phd finger protein 0.0204082 0.010889 0.0106553
Schistosoma mansoni hypothetical protein 0.959791 1 1
Brugia malayi hypothetical protein 0.0204082 0.010889 0.0185339
Echinococcus granulosus acetylcholinesterase 0.033946 0.0251435 0.0442089
Loa Loa (eye worm) jmjC domain-containing protein 0.14692 0.144098 0.245266
Loa Loa (eye worm) hypothetical protein 0.0428184 0.0344856 0.0586972
Schistosoma mansoni myst-related protein 0.0204082 0.010889 0.0106553
Loa Loa (eye worm) hypothetical protein 0.010291 0.000236219 0.000402064
Trichomonas vaginalis conserved hypothetical protein 0.0204082 0.010889 0.670843
Echinococcus granulosus carboxylesterase 5A 0.033946 0.0251435 0.0442089
Brugia malayi PHD-finger family protein 0.0204082 0.010889 0.0185339
Echinococcus granulosus chromobox protein 1 0.010291 0.000236219 0.000415335
Brugia malayi Type III restriction enzyme, res subunit family protein 0.010291 0.000236219 0.000402064
Plasmodium falciparum histone-lysine N-methyltransferase, H3 lysine-4 specific 0.0204082 0.010889 0.508317
Brugia malayi Shank2E 0.0253723 0.0161159 0.0274305
Schistosoma mansoni spingomyelin synthetase-related 0.0253723 0.0161159 0.0158834
Plasmodium falciparum zinc finger protein, putative 0.0204082 0.010889 0.508317
Trichomonas vaginalis conserved hypothetical protein 0.0204082 0.010889 0.670843
Brugia malayi Hypothetical C28H8.9 in chromosome III 0.0204082 0.010889 0.0185339
Brugia malayi Valyl-tRNA synthetase 0.010291 0.000236219 0.000402064
Onchocerca volvulus Tankyrase homolog 0.0253723 0.0161159 0.0274305
Toxoplasma gondii SWI2/SNF2-containing PHD finger protein 0.0204082 0.010889 0.28128
Loa Loa (eye worm) hypothetical protein 0.0204082 0.010889 0.0185339
Trichomonas vaginalis conserved hypothetical protein 0.0204082 0.010889 0.670843
Loa Loa (eye worm) norepinephrine transporter 0.0428184 0.0344856 0.0586972
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0204082 0.010889 0.0191457
Loa Loa (eye worm) hypothetical protein 0.134323 0.130834 0.222689
Schistosoma mansoni sex comb on midleg homolog 0.305483 0.311054 0.310892
Schistosoma mansoni hypothetical protein 0.0204082 0.010889 0.0106553
Brugia malayi AIDA-1b 0.0253723 0.0161159 0.0274305
Schistosoma mansoni hypothetical protein 0.434852 0.447272 0.447141
Schistosoma mansoni PHD zinc finger protein XAP135-related 0.0204082 0.010889 0.0106553
Schistosoma mansoni Protein aveugle 0.0253723 0.0161159 0.0158834
Loa Loa (eye worm) hypothetical protein 0.0428184 0.0344856 0.0586972
Echinococcus granulosus chromobox protein 2 0.197031 0.196862 0.346135
Loa Loa (eye worm) hypothetical protein 0.010291 0.000236219 0.000402064
Loa Loa (eye worm) tnks protein 0.0253723 0.0161159 0.0274305
Loa Loa (eye worm) hypothetical protein 0.0204082 0.010889 0.0185339
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.033946 0.0251435 0.0249132
Echinococcus granulosus pdz domain containing protein 0.0253723 0.0161159 0.028336
Toxoplasma gondii AP2 domain transcription factor AP2VIIa-7 0.0204082 0.010889 0.28128
Echinococcus multilocularis TAF3 RNA polymerase II, TATA box binding protein 0.0204082 0.010889 0.0191457
Echinococcus granulosus acetylcholinesterase 0.033946 0.0251435 0.0442089
Echinococcus granulosus Sterile alpha motif SAM 0.0253723 0.0161159 0.028336
Brugia malayi Associated with TFs and helicases family protein 0.010291 0.000236219 0.000402064
Echinococcus multilocularis chromobox protein 1 0.010291 0.000236219 0.000415335
Echinococcus granulosus Zinc finger DBF type 0.0204082 0.010889 0.0191457
Echinococcus granulosus Chromobox protein 3 0.010291 0.000236219 0.000415335
Loa Loa (eye worm) toll and interleukin 1 receptor domain-containing protein isoform f 0.0253723 0.0161159 0.0274305
Loa Loa (eye worm) AIDA-1b 0.0253723 0.0161159 0.0274305
Echinococcus multilocularis Zinc finger, DBF type 0.0204082 0.010889 0.0191457
Toxoplasma gondii PHD-finger domain-containing protein 0.0204082 0.010889 0.28128
Trichomonas vaginalis conserved hypothetical protein 0.0204082 0.010889 0.670843
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.010291 0.000236219 0.000415335

Activities

Activity type Activity value Assay description Source Reference
Dose (functional) = 100 mg kg-1 In vivo antimalarial activity of compound against Plasmodium berghei infected in mice model. Compound active at given dose. ChEMBL. 12067541
Dose (functional) = 100 mg kg-1 In vivo antimalarial activity of compound against Plasmodium berghei infected in mice model. Compound active at given dose. ChEMBL. 12067541
IC50 (functional) = 4.7 uM In vitro for antimalarial activity against chloroquine sensitive Plasmodium falciparum strain ChEMBL. 12067541
IC50 (functional) = 4.7 uM In vitro for antimalarial activity against chloroquine sensitive Plasmodium falciparum strain ChEMBL. 12067541
IC50 (functional) = 4.8 uM Compound was evaluated in vitro for antimalarial activity against chloroquine resistant Plasmodium falciparum strain ChEMBL. 12067541
IC50 (functional) = 4.8 uM Compound was evaluated in vitro for antimalarial activity against chloroquine resistant Plasmodium falciparum strain ChEMBL. 12067541

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23 12067541

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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