Detailed information for compound 695313

Basic information

Technical information
  • TDR Targets ID: 695313
  • Name: N'-(3-methoxyphenyl)-N-[2-[4-methyl-2-(3-meth ylphenyl)-1,3-thiazol-5-yl]ethyl]oxamide
  • MW: 409.501 | Formula: C22H23N3O3S
  • H donors: 2 H acceptors: 3 LogP: 4.23 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cccc(c1)NC(=O)C(=O)NCCc1sc(nc1C)c1cccc(c1)C
  • InChi: 1S/C22H23N3O3S/c1-14-6-4-7-16(12-14)22-24-15(2)19(29-22)10-11-23-20(26)21(27)25-17-8-5-9-18(13-17)28-3/h4-9,12-13H,10-11H2,1-3H3,(H,23,26)(H,25,27)
  • InChiKey: JAXOPYBTGOTCMW-UHFFFAOYSA-N  

Network

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Synonyms

  • N'-(3-methoxyphenyl)-N-[2-[4-methyl-2-(3-methylphenyl)thiazol-5-yl]ethyl]oxamide
  • N'-(3-methoxyphenyl)-N-[2-[4-methyl-2-(3-methylphenyl)-5-thiazolyl]ethyl]oxamide
  • N'-(3-methoxyphenyl)-N-[2-[4-methyl-2-(3-methylphenyl)-1,3-thiazol-5-yl]ethyl]ethanediamide
  • ZINC04392878
  • G856-3045
  • NCGC00135943-01

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens microtubule-associated protein tau Starlite/ChEMBL No references
Homo sapiens mechanistic target of rapamycin (serine/threonine kinase) Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum FKBP12-rapamycin complex-associated protein, putative Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania major target of rapamycin (TOR) kinase 1, putative Get druggable targets OG5_127212 All targets in OG5_127212
Candida albicans frameshifted from upsteam TOR2 CDS (CaP19.9461) Get druggable targets OG5_127212 All targets in OG5_127212
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related Get druggable targets OG5_127212 All targets in OG5_127212
Giardia lamblia GTOR Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Echinococcus granulosus microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Schistosoma japonicum ko:K07203 FKBP12-rapamycin complex-associated protein, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma congolense Phosphatidylinositol 3-kinase tor1 Get druggable targets OG5_127212 All targets in OG5_127212
Candida albicans similar to internal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) protein/phosphatidylinositol kinases involved in n Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma mansoni microtubule-associated protein tau Get druggable targets OG5_133504 All targets in OG5_133504
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania donovani Phosphatidylinositol 3-kinase tor2 Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative Get druggable targets OG5_127212 All targets in OG5_127212
Candida albicans similar to N terminal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) putative protein/phosphatidylinositol kinases in Get druggable targets OG5_127212 All targets in OG5_127212
Candida albicans similar to N terminal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) putative protein/phosphatidylinositol kinases in Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma congolense Phosphatidylinositol 3-kinase tor2 Get druggable targets OG5_127212 All targets in OG5_127212
Loa Loa (eye worm) phosphatidylinositol 3 Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma brucei gambiense phosphatidylinositol 3 kinase, putative Get druggable targets OG5_127212 All targets in OG5_127212
Toxoplasma gondii target of rapamycin (TOR), putative Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania mexicana phosphatidylinositol 3-kinase (tor2)-like protein Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127212 All targets in OG5_127212
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania braziliensis target of rapamycin (TOR) kinase 2, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania major target of rapamycin (TOR) kinase 2, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania infantum target of rapamycin (TOR) kinase 2, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Candida albicans similar to internal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) protein/phosphatidylinositol kinases involved in n Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 Get druggable targets OG5_127212 All targets in OG5_127212
Neospora caninum Phosphatidylinositol 3-kinase tor2, related Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania donovani Phosphatidylinositol 3-kinase tor1 Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania infantum target of rapamycin (TOR) kinase 1, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma brucei phosphatidylinositol 4-kinase, putative Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania mexicana phosphatidylinositol 3 kinase, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Echinococcus multilocularis microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Schistosoma japonicum FKBP12-rapamycin complex-associated protein, putative Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma japonicum ko:K04380 microtubule-associated protein tau, putative Get druggable targets OG5_133504 All targets in OG5_133504
Echinococcus granulosus FKBP12 rapamycin complex associated protein Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma brucei gambiense phosphatidylinositol 3-kinase tor, putative Get druggable targets OG5_127212 All targets in OG5_127212
Candida albicans frameshifted from upstream TOR2 CDS (CaP19.1905) Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma japonicum FKBP12-rapamycin complex-associated protein, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Echinococcus multilocularis FKBP12 rapamycin complex associated protein Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212

By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Schistosoma mansoni hypothetical protein 0.0293 0.2001 0.2001
Echinococcus multilocularis polycomb protein SCMH1 0.0048 0.0264 0.0234
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0021 0.0078 0.0039
Echinococcus multilocularis pyruvate kinase 0.0017 0.0048 0.0018
Echinococcus granulosus bloom syndrome protein 0.002 0.007 0.004
Plasmodium falciparum acyl-CoA synthetase 0.0054 0.0311 0.3986
Loa Loa (eye worm) hypothetical protein 0.0023 0.0091 0.049
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0054 0.0311 0.5583
Entamoeba histolytica acyl-coA synthetase, putative 0.0073 0.0441 0.7909
Trypanosoma brucei DNA polymerase kappa, putative 0.01 0.0632 0.7616
Echinococcus granulosus pyruvate kinase 0.0033 0.0163 0.0133
Trypanosoma brucei DNA polymerase kappa, putative 0.0049 0.0275 0.2901
Schistosoma mansoni DNA polymerase eta 0.0125 0.0812 0.0812
Trypanosoma brucei DNA polymerase kappa, putative 0.008 0.0491 0.575
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0134 0.202
Echinococcus granulosus dual specificity 0.0089 0.0557 0.0528
Trichomonas vaginalis PIKK family atypical protein kinase 0.0054 0.0311 0.4855
Echinococcus granulosus fmrfamide receptor 0.0034 0.0166 0.0136
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0022 0.0083 0.0158
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0056 0.0766
Brugia malayi putative neuropeptide receptor NPR1 0.0034 0.0166 0.0619
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0021 0.0078 0.0959
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0034 0.0166 0.0619
Schistosoma mansoni neuropeptide f receptor 76f 0.0034 0.0166 0.0166
Plasmodium falciparum DNA repair protein REV1, putative 0.0023 0.0088 0.0602
Mycobacterium ulcerans pyruvate kinase 0.0033 0.0163 0.0259
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0073 0.0441 0.0978
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0021 0.021
Loa Loa (eye worm) hypothetical protein 0.0034 0.0166 0.089
Mycobacterium ulcerans hypothetical protein 0.0073 0.0441 0.0978
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0034 0.0166 0.0166
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0021 0.0078 0.1093
Mycobacterium ulcerans acetyl-CoA synthetase 0.0021 0.0078 0.0039
Onchocerca volvulus 0.0034 0.0166 0.2024
Mycobacterium tuberculosis Conserved hypothetical protein 0.0104 0.0661 0.156
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0063 0.0772
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0034 0.0166 0.089
Schistosoma mansoni neuropeptide F-like receptor 0.0034 0.0166 0.0166
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0157 0.2379
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0073 0.0441 0.0991
Trypanosoma cruzi DNA damage repair protein, putative 0.0023 0.0088 0.108
Onchocerca volvulus 0.0034 0.0166 0.2024
Brugia malayi Aminopeptidase W07G4.4 in chromosome V 0.0022 0.0083 0.0158
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0018 0.0056 0.0011
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0056 0.0766
Onchocerca volvulus 0.0034 0.0166 0.2024
Brugia malayi hypothetical protein 0.0034 0.0166 0.0619
Schistosoma mansoni ap endonuclease 0.0019 0.0063 0.0063
Echinococcus multilocularis pyruvate kinase 0.0033 0.0163 0.0133
Mycobacterium tuberculosis Conserved hypothetical protein 0.0104 0.0661 0.156
Loa Loa (eye worm) hypothetical protein 0.0089 0.0554 0.2967
Loa Loa (eye worm) neuropeptide F receptor 0.0034 0.0166 0.089
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0063 0.0033
Echinococcus multilocularis microtubule associated protein 2 0.1424 1 1
Schistosoma mansoni hypothetical protein 0.0034 0.0166 0.0166
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0021 0.0078 0.0959
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0232 0.3596
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0073 0.0441 0.0978
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0034 0.0166 0.0136
Echinococcus granulosus neuropeptide s receptor 0.0034 0.0166 0.0136
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0134 0.202
Entamoeba histolytica deoxycytidyl transferase, putative 0.0073 0.0444 0.7977
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.007 0.0186
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0213 0.3278
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0054 0.0311 0.3372
Brugia malayi Tachykinin-like peptides receptor 99D 0.0034 0.0166 0.0619
Echinococcus granulosus g-protein coupled receptor 0.0034 0.0166 0.0136
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17 0.0022 0.0083 0.0353
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0073 0.0441 0.0942
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0134 0.2025
Loa Loa (eye worm) hypothetical protein 0.0034 0.0166 0.089
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0034 0.0166 0.0166
Schistosoma mansoni opsin-like receptor 0.0034 0.0166 0.0166
Schistosoma mansoni histamine h1 receptor 0.0034 0.0166 0.0166
Schistosoma mansoni cpg binding protein 0.0062 0.0366 0.0366
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0157 0.2379
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0078 0.0132
Loa Loa (eye worm) hypothetical protein 0.0054 0.0311 0.1665
Echinococcus multilocularis rhodopsin orphan GPCR 0.0034 0.0166 0.0136
Echinococcus granulosus somatostatin receptor 0.0034 0.0166 0.0136
Onchocerca volvulus 0.0034 0.0166 0.2024
Leishmania major pyruvate kinase 0.0033 0.0163 0.1411
Entamoeba histolytica protein kinase, putative 0.0089 0.0557 1
Loa Loa (eye worm) hypothetical protein 0.0034 0.0166 0.089
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0034 0.0166 0.0136
Echinococcus multilocularis rhodopsin orphan GPCR 0.0034 0.0166 0.0136
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0054 0.0311 0.3372
Brugia malayi G-protein coupled receptor 0.0034 0.0166 0.0619
Loa Loa (eye worm) hypothetical protein 0.0034 0.0166 0.089
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0034 0.0166 0.0166
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0029 0.0134 0.1883
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.007 0.0186
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0034 0.0166 0.0136
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0054 0.0311 0.1418
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0034 0.0166 0.0619
Schistosoma mansoni neuropeptide receptor 0.0034 0.0166 0.0166
Schistosoma mansoni biogenic amine receptor 0.0034 0.0166 0.0166
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.002 0.007 0.0333
Brugia malayi cytosol aminopeptidase 0.0022 0.0083 0.0158
Onchocerca volvulus 0.0034 0.0166 0.2024
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0021 0.021
Loa Loa (eye worm) hypothetical protein 0.0034 0.0166 0.089
Loa Loa (eye worm) hypothetical protein 0.0034 0.0166 0.089
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0034 0.0166 0.0136
Loa Loa (eye worm) hypothetical protein 0.0034 0.0166 0.089
Loa Loa (eye worm) hypothetical protein 0.0048 0.0264 0.1414
Loa Loa (eye worm) aminopeptidase in chromosome V 0.0022 0.0083 0.0443
Plasmodium vivax pyruvate kinase 2, putative 0.0017 0.0048 0.068
Trypanosoma cruzi DNA polymerase kappa, putative 0.01 0.0632 0.778
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0054 0.0311 0.0282
Echinococcus granulosus G protein coupled receptor 139 0.0034 0.0166 0.0136
Loa Loa (eye worm) hypothetical protein 0.001 0.000000000058882 0.00000000031548
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0034 0.0166 0.0619
Echinococcus multilocularis neuropeptide FF receptor 2 0.0034 0.0166 0.0136
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.002 0.007 0.0333
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0021 0.0078 0.0039
Trypanosoma brucei pyruvate kinase 1, putative 0.0033 0.0163 0.1411
Toxoplasma gondii propionate-CoA ligase 0.0021 0.0078 0.1093
Echinococcus granulosus neuropeptide FF receptor 2 0.0034 0.0166 0.0136
Brugia malayi hypothetical protein 0.0034 0.0166 0.0619
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0054 0.031 0.0281
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0078 0.0054
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0034 0.0166 0.0166
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0021 0.0078 0.0054
Echinococcus granulosus leucyl aminopeptidase 0.0022 0.0083 0.0053
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0034 0.0166 0.0136
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0063 0.0033
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0054 0.031 0.1415
Brugia malayi Protein kinase domain containing protein 0.0089 0.0557 0.2776
Echinococcus granulosus neuropeptide Y receptor 0.0034 0.0166 0.0136
Loa Loa (eye worm) hypothetical protein 0.0073 0.0441 0.2361
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0023 0.0092 0.0076
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0048 0.0265 0.1166
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0157 0.2379
Echinococcus granulosus pyruvate kinase 0.0017 0.0048 0.0018
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0034 0.0166 0.0166
Schistosoma mansoni PwLAP aminopeptidase (M17 family) 0.0022 0.0083 0.0083
Echinococcus multilocularis neuropeptides capa receptor 0.0034 0.0166 0.0136
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0078 0.0054
Loa Loa (eye worm) hypothetical protein 0.0034 0.0166 0.089
Echinococcus multilocularis bloom syndrome protein 0.002 0.007 0.004
Entamoeba histolytica protein kinase domain containing protein 0.0089 0.0557 1
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0018 0.0056 0.0026
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0054 0.0311 0.5583
Loa Loa (eye worm) hypothetical protein 0.0034 0.0166 0.089
Trypanosoma brucei DNA damage repair protein, putative 0.0023 0.0088 0.042
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0134 0.2025
Entamoeba histolytica acyl-CoA synthetase, putative 0.0073 0.0441 0.7909
Loa Loa (eye worm) hypothetical protein 0.0034 0.0166 0.089
Schistosoma mansoni neuropeptide F-like receptor 0.0034 0.0166 0.0166
Brugia malayi follicle stimulating hormone receptor 0.0274 0.1866 1
Loa Loa (eye worm) hypothetical protein 0.0034 0.0166 0.089
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0078 0.0132
Chlamydia trachomatis cytosol aminopeptidase 0.011 0.0707 1
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0021 0.0078 0.0054
Plasmodium vivax DNA repair protein REV1, putative 0.0023 0.0088 0.1241
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0043 0.0233 0.2338
Echinococcus granulosus biogenic amine 5HT receptor 0.0034 0.0166 0.0136
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0232 0.3596
Loa Loa (eye worm) phosphatidylinositol 3 0.0018 0.0056 0.03
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0021 0.021
Schistosoma mansoni acetyl-CoA synthetase 0.0021 0.0078 0.0078
Echinococcus multilocularis pyruvate kinase 0.0033 0.0163 0.0133
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0213 0.3278
Loa Loa (eye worm) pyruvate kinase-PB 0.0023 0.0091 0.049
Loa Loa (eye worm) hypothetical protein 0.0125 0.0812 0.4353
Trypanosoma brucei DNA polymerase kappa, putative 0.01 0.0632 0.7616
Trypanosoma brucei DNA polymerase kappa, putative 0.0057 0.033 0.3629
Echinococcus multilocularis somatostatin receptor 0.0034 0.0166 0.0136
Brugia malayi ImpB/MucB/SamB family protein 0.0125 0.0812 0.4185
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0021 0.0078 0.0048
Loa Loa (eye worm) hypothetical protein 0.0034 0.0166 0.089
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0023 0.0092 0.1293
Echinococcus multilocularis g protein coupled receptor 0.0034 0.0166 0.0136
Chlamydia trachomatis pyruvate kinase 0.0033 0.0163 0.1145
Echinococcus granulosus g protein coupled receptor 0.0034 0.0166 0.0136
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.008 0.0491 0.1122
Brugia malayi hypothetical protein 0.0034 0.0166 0.0619
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0034 0.0166 0.0166
Plasmodium falciparum M17 leucyl aminopeptidase 0.011 0.0707 1
Leishmania major DNA damage repair protein, putative 0.0023 0.0088 0.042
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0034 0.0166 0.0136
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0034 0.0166 0.0166
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0021 0.0078 0.0132
Loa Loa (eye worm) neuropeptide F receptor 0.0034 0.0166 0.089
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17 0.0022 0.0083 0.0353
Loa Loa (eye worm) hypothetical protein 0.0034 0.0166 0.089
Trichomonas vaginalis pyruvate kinase, putative 0.0033 0.0163 0.2477
Mycobacterium ulcerans hypothetical protein 0.0104 0.0661 0.1547
Echinococcus multilocularis allatostatin A receptor 0.0034 0.0166 0.0136
Brugia malayi AMP-binding enzyme family protein 0.0073 0.0441 0.2133
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0018 0.0056 0.0025
Brugia malayi Dopamine receptor protein 1 0.0034 0.0166 0.0619
Wolbachia endosymbiont of Brugia malayi N-acetylglucosamine-1-phosphate uridyltransferase 0.0565 0.3926 1
Loa Loa (eye worm) hypothetical protein 0.0034 0.0166 0.089
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.002 0.007 0.0089
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.01 0.0632 1
Echinococcus multilocularis serotonin receptor 0.0034 0.0166 0.0136
Brugia malayi Bloom's syndrome protein homolog 0.002 0.007 0.0089
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0034 0.0166 0.0136
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0034 0.0166 0.0136
Trichomonas vaginalis DNA polymerase eta, putative 0.01 0.0632 1
Loa Loa (eye worm) hypothetical protein 0.0034 0.0166 0.089
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0021 0.0078 0.0418
Schistosoma mansoni leucine aminopeptidase 0.0022 0.0083 0.0083
Echinococcus granulosus rhodopsin orphan GPCR 0.0034 0.0166 0.0136
Toxoplasma gondii exonuclease III APE 0.0019 0.0063 0.0879
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0034 0.0166 0.089
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0023 0.0092 0.067
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0021 0.0078 0.0039
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0232 0.3596
Trypanosoma cruzi hypothetical protein, conserved 0.0023 0.0088 0.108
Loa Loa (eye worm) ATP-dependent DNA helicase 0.002 0.007 0.0375
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0023 0.0087 0.0406
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0013 0.0021 0.021
Loa Loa (eye worm) hypothetical protein 0.0089 0.0554 0.2967
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0023 0.0092 0.0091
Schistosoma mansoni neuropeptide receptor 0.0034 0.0166 0.0166
Loa Loa (eye worm) hypothetical protein 0.0034 0.0166 0.089
Echinococcus multilocularis neuropeptide Y receptor 0.0034 0.0166 0.0136
Loa Loa (eye worm) hypothetical protein 0.0034 0.0166 0.089
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0018 0.0056 0.0688
Loa Loa (eye worm) hypothetical protein 0.0034 0.0166 0.089
Echinococcus multilocularis orexin receptor type 2 0.0034 0.0166 0.0136
Echinococcus granulosus rhodopsin orphan GPCR 0.0034 0.0166 0.0136
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0034 0.0166 0.0166
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0078 0.0039
Loa Loa (eye worm) hypothetical protein 0.0034 0.0166 0.089
Echinococcus multilocularis dro:myosuppressin receptor 0.0034 0.0166 0.0136
Loa Loa (eye worm) hypothetical protein 0.0054 0.0311 0.1665
Trichomonas vaginalis DNA helicase recq, putative 0.002 0.007 0.0992
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0163 0.1942
Echinococcus multilocularis dual specificity 0.0089 0.0557 0.0528
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0176 0.2697
Loa Loa (eye worm) hypothetical protein 0.0034 0.0166 0.089
Onchocerca volvulus 0.0034 0.0166 0.2024
Loa Loa (eye worm) hypothetical protein 0.0034 0.0166 0.089
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0021 0.0078 0.0453
Echinococcus granulosus tm gpcr rhodopsin 0.0034 0.0166 0.0136
Trypanosoma cruzi DNA polymerase eta, putative 0.0125 0.0812 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0051 0.029 0.0602
Echinococcus multilocularis leucyl aminopeptidase 0.0022 0.0083 0.0053
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0021 0.0078 0.0048
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0034 0.0166 0.0136
Trypanosoma cruzi cytosolic leucyl aminopeptidase, putative 0.011 0.0707 0.8705
Leishmania major DNA polymerase eta, putative 0.0125 0.0812 1
Loa Loa (eye worm) hypothetical protein 0.0034 0.0166 0.089
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0213 0.3278
Mycobacterium ulcerans molybdopterin-guanine dinucleotide biosynthesis protein A 0.0104 0.0661 0.1547
Trypanosoma brucei DNA polymerase kappa, putative 0.01 0.0632 0.7616
Schistosoma mansoni hypothetical protein 0.0836 0.5837 0.5837
Schistosoma mansoni amine GPCR 0.0034 0.0166 0.0166
Echinococcus granulosus rhodopsin orphan GPCR 0.0034 0.0166 0.0136
Echinococcus multilocularis neuropeptide receptor A26 0.0034 0.0166 0.0136
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.002 0.007 0.0089
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0043 0.0233 0.2338
Echinococcus multilocularis leucyl aminopeptidase 0.0022 0.0083 0.0053
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0154 0.2343
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0078 0.0039
Echinococcus multilocularis neuropeptide receptor 0.0034 0.0166 0.0136
Trichomonas vaginalis antibiotic synthetase, putative 0.0021 0.0078 0.1119
Echinococcus granulosus pyruvate kinase 0.0017 0.0048 0.0018
Echinococcus multilocularis pyruvate kinase 0.0026 0.0113 0.0083
Mycobacterium ulcerans hypothetical protein 0.0104 0.0661 0.1547
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0021 0.021
Echinococcus granulosus dna polymerase eta 0.0125 0.0812 0.0785
Echinococcus granulosus SAM and MBT domain containing protein 0.0048 0.0264 0.0234
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0073 0.0444 0.2381
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0163 0.0871
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0054 0.0311 0.0282
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0089 0.0557 0.6857
Echinococcus multilocularis rhodopsin orphan GPCR 0.0034 0.0166 0.0136
Echinococcus granulosus tm gpcr rhodopsin 0.0034 0.0166 0.0136
Loa Loa (eye worm) hypothetical protein 0.0034 0.0166 0.089
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0073 0.0441 0.0978
Plasmodium vivax acyl-CoA synthetase, putative 0.0054 0.0311 0.4395
Trypanosoma brucei DNA polymerase kappa, putative 0.01 0.0632 0.7616
Echinococcus granulosus rhodopsin orphan GPCR 0.0034 0.0166 0.0136
Echinococcus granulosus orexin receptor type 2 0.0034 0.0166 0.0136
Giardia lamblia DINP protein human, muc B family 0.008 0.0491 1
Loa Loa (eye worm) oxidoreductase 0.0021 0.0078 0.0418
Loa Loa (eye worm) hypothetical protein 0.0034 0.0166 0.089
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0054 0.0311 0.0656
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0021 0.021
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0034 0.0166 0.0166
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17 0.0022 0.0083 0.0353
Trichomonas vaginalis PIKK family atypical protein kinase 0.0054 0.0311 0.4855
Trypanosoma brucei metallo-peptidase, Clan MF, Family M17 0.0022 0.0083 0.0353
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.003 0.0354
Giardia lamblia Sgs1 DNA helicase, putative 0.002 0.007 0.0496
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0213 0.3278
Brugia malayi Pyruvate kinase, M2 isozyme 0.0033 0.0163 0.06
Schistosoma mansoni biogenic amine receptor 0.0034 0.0166 0.0166
Echinococcus granulosus L aminoadipate semialdehyde 0.0083 0.0514 0.0485
Loa Loa (eye worm) hypothetical protein 0.0034 0.0166 0.089
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0034 0.0166 0.0166
Schistosoma mansoni DNA helicase recq1 0.002 0.007 0.007
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0078 0.0039
Mycobacterium tuberculosis Conserved hypothetical protein 0.0073 0.0444 0.1001
Brugia malayi hypothetical protein 0.0034 0.0166 0.0619
Loa Loa (eye worm) hypothetical protein 0.0034 0.0166 0.089
Loa Loa (eye worm) hypothetical protein 0.0034 0.0166 0.089
Brugia malayi Melatonin receptor type 1A 0.0034 0.0166 0.0619
Trypanosoma brucei DNA polymerase kappa, putative 0.01 0.0632 0.7616
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17, putative 0.011 0.0707 0.8705
Echinococcus granulosus pyruvate kinase 0.0033 0.0163 0.0133
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0023 0.0092 0.0076
Echinococcus multilocularis dnaJ subfamily B 0.0836 0.5837 0.5825
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0078 0.0054
Brugia malayi Dopamine receptor protein 2 0.0034 0.0166 0.0619
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0021 0.0078 0.0291
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0034 0.0166 0.089
Echinococcus multilocularis histone acetyltransferase MYST2 0.0054 0.031 0.0281
Toxoplasma gondii pyruvate kinase PyK1 0.0033 0.0163 0.228
Schistosoma mansoni opsin-like receptor 0.0034 0.0166 0.0166
Onchocerca volvulus 0.0048 0.0264 0.4264
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0011 0.0008 0.0114
Loa Loa (eye worm) hypothetical protein 0.0034 0.0166 0.089
Trypanosoma brucei DNA polymerase IV, putative 0.01 0.0632 0.7616
Loa Loa (eye worm) RecQ helicase 0.002 0.007 0.0375
Schistosoma mansoni sex comb on midleg homolog 0.0048 0.0264 0.0264
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0063 0.1126
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0021 0.0078 0.0039
Loa Loa (eye worm) G-protein coupled receptor 0.0034 0.0166 0.089
Trypanosoma brucei DNA polymerase eta, putative 0.0125 0.0812 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.0265 0.0236
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0034 0.0166 0.0166
Leishmania major DNA polymerase eta, putative 0.0075 0.0456 0.5285
Mycobacterium leprae Probable pyruvate kinase PykA 0.0033 0.0163 0.022
Loa Loa (eye worm) hypothetical protein 0.0049 0.0275 0.1476
Echinococcus multilocularis SAM and MBT domain containing protein 0.0048 0.0264 0.0234
Brugia malayi mbt repeat family protein 0.0048 0.0264 0.1158
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0274 0.1866 1
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0073 0.0441 0.0942
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0021 0.0078 0.0054
Loa Loa (eye worm) G-protein coupled receptor 0.0034 0.0166 0.089
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.002 0.007 0.0981
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0213 0.3278
Loa Loa (eye worm) hypothetical protein 0.0034 0.0166 0.089
Loa Loa (eye worm) hypothetical protein 0.0054 0.031 0.1663
Brugia malayi RE15519p 0.0034 0.0166 0.0619
Schistosoma mansoni alpha-1 adrenergic receptor 0.0034 0.0166 0.0166
Loa Loa (eye worm) hypothetical protein 0.0011 0.0008 0.0043
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0034 0.0166 0.0619
Entamoeba histolytica hypothetical protein 0.0023 0.0092 0.1656
Echinococcus granulosus 7TM GPCR rhodopsin 0.0034 0.0166 0.0136
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0021 0.021
Schistosoma mansoni amine GPCR 0.0034 0.0166 0.0166
Brugia malayi CXXC zinc finger family protein 0.0059 0.0342 0.159
Wolbachia endosymbiont of Brugia malayi leucyl aminopeptidase 0.011 0.0707 0.1668
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0021 0.0078 0.0959
Mycobacterium ulcerans leucyl aminopeptidase 0.011 0.0707 0.1668
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0023 0.0092 0.1293
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0078 0.0039
Echinococcus granulosus dna polymerase kappa 0.01 0.0632 0.0604
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0073 0.0441 0.0991
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0265 0.0265
Loa Loa (eye worm) melatonin receptor type 1A 0.0034 0.0166 0.089
Loa Loa (eye worm) MBCTL1 0.0054 0.031 0.1663
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.0265 0.0236
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0073 0.0444 0.0444
Brugia malayi AMP-binding enzyme family protein 0.0073 0.0441 0.2133
Leishmania major DNA polymerase kappa, putative 0.0023 0.0088 0.042
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0034 0.0166 0.0136
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0034 0.0166 0.0166
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0034 0.0166 0.0166
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0054 0.0311 0.3372
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0089 0.0557 0.6857
Mycobacterium ulcerans hypothetical protein 0.0023 0.0088 0.0065
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0015 0.003 0.003
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0034 0.0166 0.0136
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0023 0.0092 0.1397
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0054 0.0311 0.0642
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0021 0.021
Brugia malayi G protein-coupled receptor 0.0034 0.0166 0.0619
Loa Loa (eye worm) hypothetical protein 0.0034 0.0166 0.089
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0034 0.0166 0.0136
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0034 0.0166 0.0166
Loa Loa (eye worm) hypothetical protein 0.0034 0.0166 0.089
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0021 0.021
Schistosoma mansoni cpg binding protein 0.0059 0.0342 0.0342
Mycobacterium ulcerans bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase 0.0565 0.3926 1
Leishmania major acetyl-CoA synthetase, putative 0.0021 0.0078 0.0291
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0063 0.0772
Trypanosoma brucei DNA polymerase IV, putative 0.0093 0.0586 0.7
Onchocerca volvulus 0.0034 0.0166 0.2024
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0213 0.3278
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0048 0.0264 0.0264
Loa Loa (eye worm) hypothetical protein 0.002 0.007 0.0375
Trichomonas vaginalis antibiotic synthetase, putative 0.0021 0.0078 0.1119
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0163 0.0871
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0034 0.0166 0.0136
Onchocerca volvulus 0.0034 0.0166 0.2024
Brugia malayi hypothetical protein 0.0034 0.0166 0.0619
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0021 0.021
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0078 0.0039
Trypanosoma brucei DNA polymerase kappa, putative 0.0057 0.033 0.3629
Plasmodium vivax M17 leucyl aminopeptidase, putative 0.011 0.0707 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0056 0.0766
Toxoplasma gondii target of rapamycin (TOR), putative 0.004 0.0213 0.2981
Echinococcus multilocularis leucyl aminopeptidase 0.0022 0.0083 0.0053
Loa Loa (eye worm) hypothetical protein 0.0054 0.0311 0.1665
Trypanosoma brucei DNA polymerase kappa, putative 0.01 0.0632 0.7616
Schistosoma mansoni biogenic amine (5HT) receptor 0.0034 0.0166 0.0166
Loa Loa (eye worm) hypothetical protein 0.0021 0.0078 0.0418
Leishmania major acetyl-CoA synthetase, putative 0.0021 0.0078 0.0291
Echinococcus granulosus cpg binding protein 0.0062 0.0366 0.0337
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0078 0.0132
Trypanosoma cruzi DNA polymerase kappa, putative 0.01 0.0632 0.778
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0054 0.0311 0.3554
Schistosoma mansoni neuropeptide receptor 0.0034 0.0166 0.0166
Mycobacterium leprae Probable cytosol aminopeptidase PepB 0.011 0.0707 0.1635
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0056 0.0766
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.002 0.007 0.0981
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.007 0.0862
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0078 0.0132
Brugia malayi mbt repeat family protein 0.0048 0.0264 0.1158
Schistosoma mansoni hypothetical protein 0.0346 0.2376 0.2376
Brugia malayi AMP-binding enzyme family protein 0.0073 0.0441 0.2133
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0163 0.1942
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0021 0.021
Schistosoma mansoni amine GPCR 0.0034 0.0166 0.0166
Trichomonas vaginalis DNA helicase recq, putative 0.002 0.007 0.0992
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0021 0.0078 0.0039
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0134 0.2025
Echinococcus granulosus rhodopsin orphan GPCR 0.0034 0.0166 0.0136
Schistosoma mansoni biogenic amine receptor 0.0034 0.0166 0.0166
Echinococcus granulosus peptide allatostatin:somatostatin 0.0034 0.0166 0.0136
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.008 0.0491 0.575
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0063 0.009
Brugia malayi G-protein coupled receptor 0.0034 0.0166 0.0619
Loa Loa (eye worm) CXXC zinc finger family protein 0.0059 0.0342 0.1833
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0051 0.029 0.0602
Echinococcus granulosus sex peptide receptor 0.0034 0.0166 0.0136
Onchocerca volvulus 0.0034 0.0166 0.2024
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0063 0.009
Loa Loa (eye worm) TYRA-2 protein 0.0034 0.0166 0.089
Brugia malayi ImpB/MucB/SamB family protein 0.0073 0.0444 0.2154
Schistosoma mansoni biogenic amine (5HT) receptor 0.0034 0.0166 0.0166
Echinococcus multilocularis L aminoadipate semialdehyde 0.0083 0.0514 0.0485
Echinococcus multilocularis neuropeptide receptor 0.0034 0.0166 0.0136
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0034 0.0166 0.2024
Leishmania major 4-coumarate:coa ligase-like protein 0.0073 0.0441 0.5084
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0021 0.021
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0023 0.0092 0.1304
Echinococcus granulosus pyruvate kinase 0.0017 0.0048 0.0018
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0021 0.0078 0.0054
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0034 0.0166 0.0136
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0063 0.0875
Giardia lamblia DNA damage repair protein 0.0023 0.0088 0.0896
Schistosoma mansoni opsin-like receptor 0.0034 0.0166 0.0166
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0089 0.0557 0.6624
Loa Loa (eye worm) hypothetical protein 0.0011 0.0005 0.0029
Echinococcus granulosus tachykinin peptides receptor 99D 0.0034 0.0166 0.0136
Brugia malayi GnHR receptor homolog 0.0034 0.0166 0.0619
Loa Loa (eye worm) hypothetical protein 0.0034 0.0166 0.089
Toxoplasma gondii leucyl aminopeptidase LAP 0.011 0.0707 0.9914
Brugia malayi larval opioid receptor 0.0034 0.0166 0.0619
Trypanosoma cruzi hypothetical protein, conserved 0.0023 0.0088 0.108
Schistosoma mansoni hypothetical protein 0.0346 0.2376 0.2376
Leishmania major 4-coumarate:coa ligase-like protein 0.0073 0.0441 0.5084
Leishmania major pyruvate kinase 0.0033 0.0163 0.1411
Loa Loa (eye worm) mbt repeat family protein 0.0048 0.0264 0.1414
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0034 0.0166 0.0166
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0063 0.0015
Loa Loa (eye worm) phosphatidylinositol 3 0.0054 0.0311 0.1666
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17 0.0022 0.0083 0.1018
Toxoplasma gondii histone lysine methyltransferase SET1 0.0111 0.0713 1
Trypanosoma brucei DNA polymerase kappa, putative 0.01 0.0632 0.7616
Echinococcus granulosus dro:myosuppressin receptor 0.0034 0.0166 0.0136
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0033 0.0163 0.0273
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0034 0.0166 0.0166
Trichomonas vaginalis PIKK family atypical protein kinase 0.0046 0.0255 0.3955
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.002 0.007 0.004
Giardia lamblia GTOR 0.0054 0.0311 0.5937
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0213 0.3278
Onchocerca volvulus 0.0073 0.0441 0.8317
Brugia malayi hypothetical protein 0.0034 0.0166 0.0619
Echinococcus granulosus rhodopsin orphan GPCR 0.0034 0.0166 0.0136
Entamoeba histolytica pyruvate kinase, putative 0.0023 0.0091 0.1641
Onchocerca volvulus 0.0034 0.0166 0.2024
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0021 0.0078 0.0291
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0232 0.3596
Brugia malayi AKH receptor 0.0034 0.0166 0.0619
Onchocerca volvulus Neuropeptide F receptor homolog 0.0034 0.0166 0.2024
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0034 0.0166 0.0136
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.002 0.007 0.004
Schistosoma mansoni microtubule-associated protein tau 0.1424 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0134 0.2025
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0021 0.021
Entamoeba histolytica protein kinase, putative 0.0089 0.0557 1
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0021 0.0078 0.0959
Echinococcus multilocularis fmrfamide receptor 0.0034 0.0166 0.0136
Loa Loa (eye worm) hypothetical protein 0.0034 0.0166 0.089
Schistosoma mansoni ap endonuclease 0.0019 0.0063 0.0063
Schistosoma mansoni amine GPCR 0.0034 0.0166 0.0166
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0026 0.0109 0.0698
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0078 0.0039
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0021 0.0078 0.0039
Echinococcus granulosus biogenic amine 5HT receptor 0.0034 0.0166 0.0136
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0063 0.0336
Echinococcus granulosus hypothetical protein 0.0034 0.0166 0.0136
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0265 0.0265
Trypanosoma brucei chrX additional, unordered contigs 0.0023 0.0088 0.042
Trypanosoma brucei unspecified product 0.005 0.0284 0.3013
Brugia malayi polk-prov protein 0.0049 0.0275 0.1222
Schistosoma mansoni serine/threonine protein kinase 0.0089 0.0557 0.0557
Trypanosoma brucei hypothetical protein, conserved 0.0023 0.0088 0.042
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0054 0.0311 0.3372
Onchocerca volvulus 0.0059 0.0342 0.6059
Onchocerca volvulus 0.0034 0.0166 0.2024
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0063 0.0875
Echinococcus granulosus leucyl aminopeptidase 0.0022 0.0083 0.0053
Echinococcus multilocularis g-protein coupled receptor 0.0034 0.0166 0.0136
Trichomonas vaginalis helicase, putative 0.0013 0.0021 0.021
Brugia malayi sulfakinin receptor protein 0.0034 0.0166 0.0619
Echinococcus granulosus polycomb protein SCMH1 0.0048 0.0264 0.0234
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0034 0.0166 0.0136
Trypanosoma brucei metallo-peptidase, Clan MF, Family M17 0.0022 0.0083 0.0353
Brugia malayi hypothetical protein 0.0034 0.0166 0.0619
Echinococcus granulosus neuropeptides capa receptor 0.0034 0.0166 0.0136
Loa Loa (eye worm) hypothetical protein 0.0021 0.0078 0.0418
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0018 0.0056 0.0056
Echinococcus multilocularis rhodopsin orphan GPCR 0.0034 0.0166 0.0136
Plasmodium vivax acetyl-CoA synthetase, putative 0.0021 0.0078 0.1102
Echinococcus multilocularis dna polymerase eta 0.0125 0.0812 0.0785
Brugia malayi neuropeptide F receptor 0.0034 0.0166 0.0619
Brugia malayi Pyruvate kinase, muscle isozyme 0.0033 0.0163 0.06
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0034 0.0166 0.0136
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0063 0.0048
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0021 0.0078 0.1399
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0075 0.0456 0.6389
Echinococcus granulosus neuropeptides capa receptor 0.0034 0.0166 0.0136
Leishmania major phosphopantetheinyl transferase-like protein 0.0023 0.0092 0.048
Mycobacterium tuberculosis Probable aminopeptidase PepB 0.011 0.0707 0.168
Loa Loa (eye worm) hypothetical protein 0.0034 0.0166 0.089
Trypanosoma cruzi DNA polymerase kappa, putative 0.01 0.0632 0.778
Giardia lamblia Pyruvate kinase 0.0033 0.0163 0.2587
Loa Loa (eye worm) hypothetical protein 0.0034 0.0166 0.089
Echinococcus multilocularis geminin 0.0346 0.2376 0.2352
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0054 0.0311 0.0311
Plasmodium vivax pyruvate kinase, putative 0.0033 0.0163 0.23
Onchocerca volvulus 0.0034 0.0166 0.2024
Loa Loa (eye worm) histone methyltransferase 0.0018 0.0056 0.0298
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0034 0.0166 0.0166
Schistosoma mansoni hypothetical protein 0.0034 0.0166 0.0166
Echinococcus granulosus leucine aminopeptidase protein 0.011 0.0707 0.0679
Loa Loa (eye worm) hypothetical protein 0.0034 0.0166 0.089
Echinococcus granulosus neuropeptide receptor A26 0.0034 0.0166 0.0136
Loa Loa (eye worm) hypothetical protein 0.0034 0.0166 0.089
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0034 0.0166 0.0166
Mycobacterium tuberculosis Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU 0.0565 0.3926 1
Brugia malayi Serotonin receptor 0.0034 0.0166 0.0619
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.0265 0.0236
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.0265 0.0236
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0034 0.0166 0.0136
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0163 0.1942
Mycobacterium leprae Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU 0.0565 0.3926 1
Trypanosoma brucei hypothetical protein, conserved 0.0023 0.0092 0.048
Onchocerca volvulus 0.0034 0.0166 0.2024
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0163 0.0871
Echinococcus granulosus neuropeptide receptor 0.0034 0.0166 0.0136
Echinococcus granulosus neuropeptide Y receptor 0.0034 0.0166 0.0136
Mycobacterium ulcerans acyl-CoA synthetase 0.0073 0.0441 0.0978
Trypanosoma cruzi target of rapamycin kinase 3 0.0043 0.0233 0.2865
Loa Loa (eye worm) hypothetical protein 0.0034 0.0166 0.089
Echinococcus multilocularis g protein coupled receptor 0.0034 0.0166 0.0136
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0034 0.0166 0.0166
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0023 0.0088 0.123
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0013 0.0021 0.021
Leishmania major 4-coumarate:coa ligase-like protein 0.0073 0.0441 0.5084
Echinococcus multilocularis rhodopsin orphan GPCR 0.0034 0.0166 0.0136
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0034 0.0166 0.0136
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0034 0.0166 0.0136
Echinococcus granulosus ATP dependent DNA helicase Q1 0.002 0.007 0.004
Brugia malayi Serotonin receptor 0.0034 0.0166 0.0619
Echinococcus granulosus dnaJ subfamily B 0.0836 0.5837 0.5825
Echinococcus granulosus tm gpcr rhodopsin 0.0034 0.0166 0.0136
Brugia malayi neuropeptide F receptor 0.0034 0.0166 0.0619
Loa Loa (eye worm) hypothetical protein 0.0054 0.0311 0.1665
Trypanosoma cruzi pyruvate kinase 2, putative 0.0033 0.0163 0.2002
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0021 0.0078 0.1093
Brugia malayi G protein-coupled receptor F59B2.13 0.0034 0.0166 0.0619
Echinococcus multilocularis neuropeptides capa receptor 0.0034 0.0166 0.0136
Onchocerca volvulus 0.0083 0.0514 1
Loa Loa (eye worm) hypothetical protein 0.0034 0.0166 0.089
Brugia malayi Aminopeptidase ZK353.6 in chromosome III 0.0022 0.0083 0.0158
Trypanosoma brucei unspecified product 0.0093 0.0586 0.7
Trichomonas vaginalis pyruvate kinase, putative 0.0033 0.0163 0.2477
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0034 0.0166 0.0166
Trypanosoma cruzi DNA damage repair protein, putative 0.0023 0.0088 0.108
Brugia malayi hypothetical protein 0.0034 0.0166 0.0619
Mycobacterium ulcerans acyl-CoA synthetase 0.0073 0.0441 0.0978
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0034 0.0166 0.0619
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0048 0.0265 0.1422
Loa Loa (eye worm) hypothetical protein 0.0034 0.0166 0.089
Trichomonas vaginalis PIKK family atypical protein kinase 0.0054 0.0311 0.4855
Echinococcus granulosus ATP dependent DNA helicase Q5 0.002 0.007 0.004
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0034 0.0166 0.0166
Brugia malayi Dopamine receptor 0.0034 0.0166 0.0619
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0078 0.0054
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0063 0.0887
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0021 0.0078 0.0291
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0078 0.0039
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0185 0.283
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0051 0.029 0.0602
Schistosoma mansoni terminal deoxycytidyl transferase 0.0073 0.0444 0.0444
Schistosoma mansoni amine GPCR 0.0034 0.0166 0.0166
Echinococcus granulosus alpha 1A adrenergic receptor 0.0034 0.0166 0.0136
Trypanosoma brucei aminopeptidase, putative 0.0022 0.0083 0.0353
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0063 0.0331
Echinococcus multilocularis rhodopsin orphan GPCR 0.0034 0.0166 0.0136
Echinococcus multilocularis G-protein coupled receptor, putative 0.0034 0.0166 0.0136
Trypanosoma brucei DNA polymerase IV, putative 0.01 0.0632 0.7616
Echinococcus granulosus ankyrin repeat domain containing protein 17 0.0022 0.0083 0.0053
Mycobacterium ulcerans acyl-CoA synthetase 0.0073 0.0441 0.0978
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0021 0.0078 0.0039
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0051 0.029 0.0602
Loa Loa (eye worm) hypothetical protein 0.0083 0.0514 0.2754
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0232 0.3596
Brugia malayi ORL1-like opioid receptor 0.0034 0.0166 0.0619
Schistosoma mansoni cpg binding protein 0.0062 0.0366 0.0366
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0034 0.0166 0.089
Trypanosoma brucei DNA polymerase kappa, putative 0.01 0.0632 0.7616
Entamoeba histolytica acyl-CoA synthetase, putative 0.0073 0.0441 0.7909
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0021 0.0078 0.0418
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0054 0.0311 0.3828
Echinococcus multilocularis serotonin receptor 0.0034 0.0166 0.0136
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0023 0.0092 0.0076
Mycobacterium leprae conserved hypothetical protein 0.0023 0.0092 0.0037
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0154 0.2343
Mycobacterium ulcerans DNA polymerase IV 0.01 0.0632 0.1474
Schistosoma mansoni pyruvate kinase 0.0017 0.0048 0.0048
Trypanosoma brucei pyruvate kinase 1 0.0033 0.0163 0.1411
Schistosoma mansoni adenoreceptor 0.0034 0.0166 0.0166
Trichomonas vaginalis DNA helicase recq1, putative 0.002 0.007 0.0992
Echinococcus multilocularis rhodopsin orphan GPCR 0.0034 0.0166 0.0136
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0021 0.0078 0.0054
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0021 0.021
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0078 0.0039
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0089 0.0557 0.2985
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0021 0.021
Loa Loa (eye worm) hypothetical protein 0.0034 0.0166 0.089
Loa Loa (eye worm) hypothetical protein 0.0073 0.0441 0.2361
Toxoplasma gondii eukaryotic initiation factor-2B, gamma subunit, putative 0.0104 0.0661 0.9259
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0073 0.0444 0.0415
Plasmodium falciparum pyruvate kinase 0.0033 0.0163 0.1738
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17 0.0022 0.0083 0.1018
Echinococcus multilocularis sex peptide receptor 0.0034 0.0166 0.0136
Trypanosoma brucei metallo-peptidase, Clan MF, Family M17 0.011 0.0707 0.8609
Leishmania major DNA polymerase kappa, putative 0.008 0.0491 0.575
Echinococcus granulosus 7tm_1 domain containing protein 0.0034 0.0166 0.0136
Loa Loa (eye worm) hypothetical protein 0.0054 0.0311 0.1665
Trypanosoma brucei DNA polymerase kappa, putative 0.01 0.0632 0.7616
Echinococcus granulosus serotonin receptor 0.0034 0.0166 0.0136
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0056 0.0766
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0073 0.0441 0.0978
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0021 0.0078 0.0054
Loa Loa (eye worm) hypothetical protein 0.0034 0.0166 0.089
Treponema pallidum licC protein (licC) 0.0104 0.0661 1
Loa Loa (eye worm) hypothetical protein 0.0073 0.0441 0.2361
Echinococcus multilocularis leucine aminopeptidase protein 0.011 0.0707 0.0679
Schistosoma mansoni hypothetical protein 0.0034 0.0166 0.0166
Trypanosoma cruzi pyruvate kinase 2, putative 0.0033 0.0163 0.2002
Loa Loa (eye worm) hypothetical protein 0.0034 0.0166 0.089
Echinococcus multilocularis fmrfamide receptor 0.0034 0.0166 0.0136
Echinococcus granulosus histone acetyltransferase MYST2 0.0054 0.031 0.0281
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0124 0.0807 0.0807
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0134 0.202
Toxoplasma gondii pyruvate kinase PyKII 0.0017 0.0048 0.0674
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0018 0.0056 0.0026
Entamoeba histolytica recQ family helicase, putative 0.002 0.007 0.1257
Echinococcus multilocularis rhodopsin orphan GPCR 0.0034 0.0166 0.0136
Echinococcus granulosus allatostatin A receptor 0.0034 0.0166 0.0136
Echinococcus multilocularis pyruvate kinase 0.0017 0.0048 0.0018
Schistosoma mansoni DNA polymerase IV / kappa 0.0023 0.0088 0.0088
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0018 0.0056 0.0025
Loa Loa (eye worm) hypothetical protein 0.0033 0.0163 0.0871
Schistosoma mansoni growth hormone secretagogue receptor 0.0034 0.0166 0.0166
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0021 0.0078 0.0039
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0083 0.0514 0.0514
Schistosoma mansoni pyruvate kinase 0.0033 0.0163 0.0163
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0054 0.031 0.0281
Brugia malayi hypothetical protein 0.0034 0.0166 0.0619
Leishmania major cytosolic leucyl aminopeptidase,metallo-peptidase, Clan MF, Family M17 0.011 0.0707 0.8609
Echinococcus granulosus geminin 0.0346 0.2376 0.2352
Loa Loa (eye worm) aminopeptidase in chromosome III 0.0022 0.0083 0.0443
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0021 0.021
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0073 0.0444 0.0415
Echinococcus granulosus rhodopsin orphan GPCR 0.0034 0.0166 0.0136
Entamoeba histolytica hypothetical protein 0.0089 0.0557 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0265 0.0265
Echinococcus granulosus neuropeptide receptor 0.0034 0.0166 0.0136
Brugia malayi putative neuropeptide receptor 0.0034 0.0166 0.0619
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0048 0.0264 0.4264
Schistosoma mansoni myelin transcription factor 1 myt1 0.0054 0.031 0.031
Trypanosoma brucei hypothetical protein, conserved 0.0023 0.0088 0.042
Schistosoma mansoni hypothetical protein 0.0034 0.0166 0.0166
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0191 0.1281 0.1255
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0191 0.1281 0.1255
Brugia malayi hypothetical protein 0.0034 0.0166 0.0619
Echinococcus multilocularis cpg binding protein 0.0062 0.0366 0.0337
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0018 0.0056 0.0688
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0083 0.0514 0.2538
Schistosoma mansoni sex comb on midleg homolog 0.0048 0.0264 0.0264
Echinococcus multilocularis pyruvate kinase 0.0017 0.0048 0.0018
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0021 0.0078 0.0132
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0063 0.095
Echinococcus multilocularis G protein coupled receptor 139 0.0034 0.0166 0.0136
Schistosoma mansoni myosin xvIII 0.0034 0.0166 0.0166
Schistosoma mansoni pyruvate kinase 0.0033 0.0163 0.0163
Echinococcus multilocularis g protein coupled receptor 0.0034 0.0166 0.0136
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0054 0.0311 0.3828
Schistosoma mansoni DNA helicase recq5 0.002 0.007 0.007
Onchocerca volvulus 0.0034 0.0166 0.2024
Echinococcus multilocularis dna polymerase kappa 0.01 0.0632 0.0604
Trypanosoma brucei unspecified product 0.005 0.0284 0.3013
Onchocerca volvulus 0.0034 0.0166 0.2024
Echinococcus granulosus g protein coupled receptor 0.0034 0.0166 0.0136
Trypanosoma brucei DNA polymerase kappa, putative 0.0057 0.033 0.3629
Loa Loa (eye worm) hypothetical protein 0.0034 0.0166 0.089
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0063 0.0222
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0089 0.0557 0.6624
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0021 0.0078 0.0054
Schistosoma mansoni neuropeptide receptor 0.0034 0.0166 0.0166
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0034 0.0166 0.0166
Mycobacterium ulcerans DNA polymerase IV 0.01 0.0632 0.1474
Trypanosoma brucei DNA polymerase kappa, putative 0.0049 0.0275 0.2901
Onchocerca volvulus 0.0034 0.0166 0.2024
Trypanosoma brucei DNA damage repair protein, putative 0.0023 0.0088 0.042
Echinococcus multilocularis neuropeptide Y receptor 0.0034 0.0166 0.0136
Loa Loa (eye worm) hypothetical protein 0.0034 0.0166 0.089
Echinococcus granulosus g protein coupled receptor 0.0034 0.0166 0.0136
Echinococcus multilocularis neuropeptide s receptor 0.0034 0.0166 0.0136
Trypanosoma cruzi DNA polymerase kappa, putative 0.01 0.0632 0.778
Trypanosoma cruzi DNA polymerase eta, putative 0.0075 0.0456 0.561
Onchocerca volvulus 0.0034 0.0166 0.2024

Activities

Activity type Activity value Assay description Source Reference
Potency (binding) = 2.8184 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 13.0918 uM PUBCHEM_BIOASSAY: Acumen qHTS Assay for Inhibitors of the mTORC1 Signaling Pathway in MEF (Tsc2-/-, p53-/-) Cells: Sytravon. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2660, AID2666, AID2667, AID2668, AID2681, AID504465] ChEMBL. No reference
Potency (functional) 23.2809 uM PUBCHEM_BIOASSAY: IN Cell qHTS Assay for Inhibitors of the mTORC1 Signaling Pathway in MEF (Tsc2-/-, p53-/-) Cells: Sytravon. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2660, AID2666, AID2667, AID2668, AID2681, AID493208] ChEMBL. No reference
Potency (functional) 23.9341 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) 35.4813 uM PubChem BioAssay. qHTS Assay to Identify Small Molecule Activators of BRCA1 Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 39.8107 uM PubChem BioAssay. A Novel Cell-Based Assay to Identify Small Molecules for B -Galactocerebrosidase. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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