TDR Targets

Basic information

Technical information

TDR Targets ID: 695313
Name: N'-(3-methoxyphenyl)-N-[2-[4-methyl-2-(3-meth ylphenyl)-1,3-thiazol-5-yl]ethyl]oxamide
MW: 409.501 | Formula: C22H23N3O3S
H donors: 2 H acceptors: 3 LogP: 4.23 Rotable bonds: 9
Rule of 5 violations (Lipinski): 1
SMILES: COc1cccc(c1)NC(=O)C(=O)NCCc1sc(nc1C)c1cccc(c1)C
InChi: 1S/C22H23N3O3S/c1-14-6-4-7-16(12-14)22-24-15(2)19(29-22)10-11-23-20(26)21(27)25-17-8-5-9-18(13-17)28-3/h4-9,12-13H,10-11H2,1-3H3,(H,23,26)(H,25,27)
InChiKey: JAXOPYBTGOTCMW-UHFFFAOYSA-N

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N'-(3-methoxyphenyl)-N-[2-[4-methyl-2-(3-methylphenyl)thiazol-5-yl]ethyl]oxamide
N'-(3-methoxyphenyl)-N-[2-[4-methyl-2-(3-methylphenyl)-5-thiazolyl]ethyl]oxamide
N'-(3-methoxyphenyl)-N-[2-[4-methyl-2-(3-methylphenyl)-1,3-thiazol-5-yl]ethyl]ethanediamide
ZINC04392878
G856-3045
NCGC00135943-01

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	microtubule-associated protein tau	Starlite/ChEMBL	No references
Homo sapiens	mechanistic target of rapamycin (serine/threonine kinase)	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trypanosoma congolense	Phosphatidylinositol 3-kinase tor1	Get druggable targets OG5_127212	All targets in OG5_127212
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Leishmania donovani	Phosphatidylinositol 3-kinase tor1	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Leishmania infantum	target of rapamycin (TOR) kinase 2, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Schistosoma japonicum	ko:K04380 microtubule-associated protein tau, putative	Get druggable targets OG5_133504	All targets in OG5_133504
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Schistosoma japonicum	FKBP12-rapamycin complex-associated protein, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Candida albicans	frameshifted from upstream TOR2 CDS (CaP19.1905)	Get druggable targets OG5_127212	All targets in OG5_127212
Leishmania braziliensis	target of rapamycin (TOR) kinase 2, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Trypanosoma brucei gambiense	phosphatidylinositol 3-kinase tor, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Leishmania mexicana	phosphatidylinositol 3 kinase, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Toxoplasma gondii	target of rapamycin (TOR), putative	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	Get druggable targets OG5_127212	All targets in OG5_127212
Candida albicans	similar to internal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) protein/phosphatidylinositol kinases involved in n	Get druggable targets OG5_127212	All targets in OG5_127212
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127212	All targets in OG5_127212
Candida albicans	similar to N terminal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) putative protein/phosphatidylinositol kinases in	Get druggable targets OG5_127212	All targets in OG5_127212
Candida albicans	similar to internal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) protein/phosphatidylinositol kinases involved in n	Get druggable targets OG5_127212	All targets in OG5_127212
Candida albicans	similar to N terminal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) putative protein/phosphatidylinositol kinases in	Get druggable targets OG5_127212	All targets in OG5_127212
Echinococcus granulosus	microtubule associated protein 2	Get druggable targets OG5_133504	All targets in OG5_133504
Candida albicans	frameshifted from upsteam TOR2 CDS (CaP19.9461)	Get druggable targets OG5_127212	All targets in OG5_127212
Neospora caninum	Phosphatidylinositol 3-kinase tor2, related	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Leishmania major	target of rapamycin (TOR) kinase 1, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Echinococcus multilocularis	microtubule associated protein 2	Get druggable targets OG5_133504	All targets in OG5_133504
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	Get druggable targets OG5_127212	All targets in OG5_127212
Loa Loa (eye worm)	phosphatidylinositol 3	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Leishmania infantum	target of rapamycin (TOR) kinase 1, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Leishmania mexicana	phosphatidylinositol 3-kinase (tor2)-like protein	Get druggable targets OG5_127212	All targets in OG5_127212
Leishmania donovani	Phosphatidylinositol 3-kinase tor2	Get druggable targets OG5_127212	All targets in OG5_127212
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Giardia lamblia	GTOR	Get druggable targets OG5_127212	All targets in OG5_127212
Schistosoma japonicum	ko:K07203 FKBP12-rapamycin complex-associated protein, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	Get druggable targets OG5_127212	All targets in OG5_127212
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trypanosoma brucei	phosphatidylinositol 3-kinase tor, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trypanosoma congolense	Phosphatidylinositol 3-kinase tor2	Get druggable targets OG5_127212	All targets in OG5_127212
Schistosoma japonicum	FKBP12-rapamycin complex-associated protein, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	Get druggable targets OG5_127212	All targets in OG5_127212
Schistosoma japonicum	FKBP12-rapamycin complex-associated protein, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Schistosoma mansoni	microtubule-associated protein tau	Get druggable targets OG5_133504	All targets in OG5_133504
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	Get druggable targets OG5_127212	All targets in OG5_127212
Leishmania major	target of rapamycin (TOR) kinase 2, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Trypanosoma brucei gambiense	phosphatidylinositol 3 kinase, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	Get druggable targets OG5_127212	All targets in OG5_127212

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	0.0054	0.0311	0.5583
Mycobacterium ulcerans	phenyloxazoline synthase MbtB	0.0021	0.0078	0.0039
Trypanosoma brucei	metallo-peptidase, Clan MF, Family M17	0.011	0.0707	0.8609
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0013	0.0021	0.021
Treponema pallidum	4'-phosphopantetheinyl transferase	0.0023	0.0092	0.1397
Schistosoma mansoni	biogenic amine receptor	0.0034	0.0166	0.0166
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0078	0.0418
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0166	0.089
Leishmania major	DNA damage repair protein, putative	0.0023	0.0088	0.042
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0034	0.0166	0.0136
Loa Loa (eye worm)	oxidoreductase	0.0021	0.0078	0.0418
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0166	0.089
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0166	0.089
Mycobacterium leprae	Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU	0.0565	0.3926	1
Echinococcus granulosus	g protein coupled receptor	0.0034	0.0166	0.0136
Entamoeba histolytica	protein kinase, putative	0.0089	0.0557	1
Echinococcus multilocularis	serotonin receptor	0.0034	0.0166	0.0136
Mycobacterium ulcerans	acyl-CoA synthetase	0.0021	0.0078	0.0039
Trypanosoma cruzi	long-chain-fatty-acid-CoA ligase, putative	0.0021	0.0078	0.0959
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0034	0.0166	0.0136
Onchocerca volvulus		0.0034	0.0166	0.2024
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0034	0.0166	0.0619
Trypanosoma cruzi	pyruvate kinase 2, putative	0.0033	0.0163	0.2002
Trypanosoma brucei	DNA polymerase kappa, putative	0.01	0.0632	0.7616
Trypanosoma cruzi	long-chain-fatty-acid-CoA ligase, putative	0.0021	0.0078	0.0959
Echinococcus granulosus	g-protein coupled receptor	0.0034	0.0166	0.0136
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0034	0.0166	0.0136
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0018	0.0056	0.0688
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0019	0.0063	0.009
Schistosoma mansoni	biogenic amine receptor	0.0034	0.0166	0.0166
Brugia malayi	hypothetical protein	0.0034	0.0166	0.0619
Echinococcus multilocularis	phosphatidylinositol 3 and 4 kinase	0.0018	0.0056	0.0026
Trypanosoma cruzi	DNA polymerase kappa, putative	0.01	0.0632	0.778
Loa Loa (eye worm)	AMP-binding enzyme family protein	0.0021	0.0078	0.0418
Trichomonas vaginalis	conserved hypothetical protein	0.0013	0.0021	0.021
Echinococcus granulosus	leucyl aminopeptidase	0.0022	0.0083	0.0053
Mycobacterium ulcerans	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase	0.0565	0.3926	1
Brugia malayi	Melatonin receptor type 1A	0.0034	0.0166	0.0619
Trypanosoma brucei	DNA damage repair protein, putative	0.0023	0.0088	0.042
Echinococcus multilocularis	acetyl coenzyme A synthetase, cytoplasmic	0.0021	0.0078	0.0048
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0054	0.0311	0.4855
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0166	0.089
Loa Loa (eye worm)	TYRA-2 protein	0.0034	0.0166	0.089
Leishmania major	acetyl-CoA synthetase, putative	0.0021	0.0078	0.0291
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0034	0.0166	0.089
Echinococcus multilocularis	serotonin receptor	0.0034	0.0166	0.0136
Leishmania major	target of rapamycin (TOR) kinase 1, putative	0.0054	0.0311	0.3372
Trichomonas vaginalis	PIKK family atypical protein kinase	0.004	0.0213	0.3278
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0056	0.0766
Echinococcus multilocularis	neuropeptide s receptor	0.0034	0.0166	0.0136
Trypanosoma brucei	DNA polymerase kappa, putative	0.0049	0.0275	0.2901
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	0.0054	0.0311	0.3828
Trypanosoma cruzi	acetyl-CoA synthetase, putative	0.0021	0.0078	0.0959
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0034	0.0166	0.0136
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0073	0.0441	0.0978
Plasmodium falciparum	acetyl-CoA synthetase, putative	0.0021	0.0078	0.0453
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0166	0.089
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0059	0.0342	0.1833
Brugia malayi	G-protein coupled receptor	0.0034	0.0166	0.0619
Trypanosoma brucei	DNA polymerase kappa, putative	0.01	0.0632	0.7616
Trypanosoma cruzi	ATP-dependent DEAD/H DNA helicase recQ, putative	0.002	0.007	0.0862
Brugia malayi	AMP-binding enzyme family protein	0.0073	0.0441	0.2133
Trichomonas vaginalis	PIKK family atypical protein kinase	0.004	0.0213	0.3278
Wolbachia endosymbiont of Brugia malayi	N-acetylglucosamine-1-phosphate uridyltransferase	0.0565	0.3926	1
Trichomonas vaginalis	conserved hypothetical protein	0.0013	0.0021	0.021
Mycobacterium tuberculosis	Probable aminopeptidase PepB	0.011	0.0707	0.168
Echinococcus multilocularis	pyruvate kinase	0.0033	0.0163	0.0133
Echinococcus multilocularis	neuropeptide receptor A26	0.0034	0.0166	0.0136
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0166	0.089
Echinococcus multilocularis	g protein coupled receptor	0.0034	0.0166	0.0136
Leishmania major	DNA polymerase kappa, putative	0.0023	0.0088	0.042
Echinococcus granulosus	g protein coupled receptor	0.0034	0.0166	0.0136
Brugia malayi	Dopamine receptor	0.0034	0.0166	0.0619
Echinococcus granulosus	phosphatidylinositol 3 and 4 kinase	0.0018	0.0056	0.0026
Echinococcus multilocularis	bloom syndrome protein	0.002	0.007	0.004
Echinococcus multilocularis	terminal deoxycytidyl transferase rev1	0.0073	0.0444	0.0415
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0034	0.0166	0.0136
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0034	0.0166	0.0136
Plasmodium falciparum	DNA repair protein REV1, putative	0.0023	0.0088	0.0602
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0311	0.1665
Brugia malayi	Pyruvate kinase, muscle isozyme	0.0033	0.0163	0.06
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0034	0.0166	0.089
Plasmodium vivax	acyl-CoA synthetase, putative	0.0054	0.0311	0.4395
Brugia malayi	larval opioid receptor	0.0034	0.0166	0.0619
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0073	0.0441	0.0978
Leishmania major	4-coumarate:coa ligase-like protein	0.0073	0.0441	0.5084
Onchocerca volvulus		0.0034	0.0166	0.2024
Brugia malayi	hypothetical protein	0.0034	0.0166	0.0619
Schistosoma mansoni	hypothetical protein	0.0034	0.0166	0.0166
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0048	0.0265	0.1166
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0034	0.0166	0.0136
Plasmodium vivax	pyruvate kinase, putative	0.0033	0.0163	0.23
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.0054	0.0311	0.3372
Onchocerca volvulus		0.0034	0.0166	0.2024
Echinococcus granulosus	suppression of tumorigenicity 18 protein	0.0054	0.031	0.0281
Plasmodium vivax	holo-[acyl-carrier-protein] synthase, putative	0.0023	0.0092	0.1304
Echinococcus multilocularis	dna polymerase eta	0.0125	0.0812	0.0785
Brugia malayi	Serotonin receptor	0.0034	0.0166	0.0619
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0166	0.089
Trichomonas vaginalis	PIKK family atypical protein kinase	0.004	0.0213	0.3278
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0111	0.0713	1
Echinococcus granulosus	neuropeptide receptor	0.0034	0.0166	0.0136
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0166	0.089
Loa Loa (eye worm)	AMP-binding enzyme family protein	0.0021	0.0078	0.0418
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0019	0.0063	0.009
Leishmania major	ATP-dependent DEAD/H DNA helicase recQ, putative	0.002	0.007	0.0186
Brugia malayi	ImpB/MucB/SamB family protein	0.0073	0.0444	0.2154
Mycobacterium leprae	Probable pyruvate kinase PykA	0.0033	0.0163	0.022
Trypanosoma brucei	DNA polymerase kappa, putative	0.0057	0.033	0.3629
Loa Loa (eye worm)	aminopeptidase in chromosome III	0.0022	0.0083	0.0443
Echinococcus granulosus	dna polymerase eta	0.0125	0.0812	0.0785
Mycobacterium ulcerans	acetyl-CoA synthetase	0.0021	0.0078	0.0039
Plasmodium falciparum	ADP-dependent DNA helicase RecQ	0.002	0.007	0.0333
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0166	0.089
Onchocerca volvulus		0.0059	0.0342	0.6059
Echinococcus multilocularis	pyruvate kinase	0.0017	0.0048	0.0018
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0034	0.0166	0.0136
Trichomonas vaginalis	DNA helicase recq1, putative	0.002	0.007	0.0992
Schistosoma mansoni	hypothetical protein	0.0034	0.0166	0.0166
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0034	0.0166	0.0136
Echinococcus multilocularis	g-protein coupled receptor	0.0034	0.0166	0.0136
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	0.0054	0.0311	0.5583
Mycobacterium ulcerans	non-ribosomal peptide synthetase MbtF	0.0021	0.0078	0.0039
Echinococcus multilocularis	orexin receptor type 2	0.0034	0.0166	0.0136
Mycobacterium ulcerans	hypothetical protein	0.0023	0.0088	0.0065
Schistosoma mansoni	myelin transcription factor 1 myt1	0.0054	0.031	0.031
Brugia malayi	ATP-dependent DNA helicase, RecQ family protein	0.002	0.007	0.0089
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0034	0.0166	0.0166
Trichomonas vaginalis	ap endonuclease, putative	0.0019	0.0063	0.0875
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0021	0.0078	0.0132
Leishmania major	target of rapamycin kinase (TOR) kinase 3	0.0043	0.0233	0.2338
Schistosoma mansoni	microtubule-associated protein tau	0.1424	1	1
Loa Loa (eye worm)	pyruvate kinase	0.0033	0.0163	0.0871
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0166	0.089
Echinococcus multilocularis	microtubule associated protein 2	0.1424	1	1
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0166	0.089
Echinococcus granulosus	ankyrin repeat domain containing protein 17	0.0022	0.0083	0.0053
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0034	0.0166	0.0166
Schistosoma mansoni	hypothetical protein	0.0293	0.2001	0.2001
Plasmodium vivax	M17 leucyl aminopeptidase, putative	0.011	0.0707	1
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0034	0.0166	0.0136
Brugia malayi	AMP-binding enzyme family protein	0.0073	0.0441	0.2133
Schistosoma mansoni	pyruvate kinase	0.0033	0.0163	0.0163
Mycobacterium tuberculosis	Peptide synthetase MbtE (peptide synthase)	0.0021	0.0078	0.0054
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0034	0.0166	0.2024
Brugia malayi	hypothetical protein	0.0034	0.0166	0.0619
Schistosoma mansoni	ap endonuclease	0.0019	0.0063	0.0063
Brugia malayi	Bloom's syndrome protein homolog	0.002	0.007	0.0089
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.0043	0.0233	0.2338
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0034	0.0166	0.0166
Toxoplasma gondii	exonuclease III APE	0.0019	0.0063	0.0879
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0073	0.0441	0.0991
Leishmania major	4-coumarate:coa ligase-like protein	0.0073	0.0441	0.5084
Trichomonas vaginalis	PIKK family atypical protein kinase	0.004	0.0213	0.3278
Echinococcus multilocularis	ATP dependent DNA helicase Q5	0.002	0.007	0.004
Trypanosoma cruzi	target of rapamycin kinase 3	0.0043	0.0233	0.2865
Onchocerca volvulus		0.0034	0.0166	0.2024
Brugia malayi	cytosol aminopeptidase	0.0022	0.0083	0.0158
Onchocerca volvulus		0.0083	0.0514	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0054	0.0311	0.4855
Trypanosoma brucei	DNA polymerase kappa, putative	0.01	0.0632	0.7616
Entamoeba histolytica	acyl-coA synthetase, putative	0.0073	0.0441	0.7909
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0015	0.003	0.0354
Trypanosoma brucei	long-chain-fatty-acid-CoA ligase, putative	0.0021	0.0078	0.0291
Loa Loa (eye worm)	RecQ helicase	0.002	0.007	0.0375
Trypanosoma brucei	DNA polymerase kappa, putative	0.008	0.0491	0.575
Trypanosoma brucei	unspecified product	0.0093	0.0586	0.7
Mycobacterium ulcerans	hypothetical protein	0.0104	0.0661	0.1547
Leishmania major	cytosolic leucyl aminopeptidase,metallo-peptidase, Clan MF, Family M17	0.011	0.0707	0.8609
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0275	0.1476
Echinococcus granulosus	neuropeptide receptor A26	0.0034	0.0166	0.0136
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0018	0.0056	0.0025
Toxoplasma gondii	4'-phosphopantetheinyl transferase superfamily protein	0.0023	0.0092	0.1293
Mycobacterium leprae	conserved hypothetical protein	0.0023	0.0092	0.0037
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0166	0.089
Onchocerca volvulus		0.0034	0.0166	0.2024
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0043	0.0232	0.3596
Onchocerca volvulus		0.0034	0.0166	0.2024
Echinococcus multilocularis	g protein coupled receptor	0.0034	0.0166	0.0136
Loa Loa (eye worm)	neuropeptide F receptor	0.0034	0.0166	0.089
Trypanosoma brucei	DNA polymerase kappa, putative	0.01	0.0632	0.7616
Trichomonas vaginalis	pyruvate kinase, putative	0.0033	0.0163	0.2477
Schistosoma mansoni	neuropeptide receptor	0.0034	0.0166	0.0166
Mycobacterium ulcerans	acyl-CoA synthetase	0.0073	0.0441	0.0978
Brugia malayi	hypothetical protein	0.0034	0.0166	0.0619
Giardia lamblia	DNA damage repair protein	0.0023	0.0088	0.0896
Loa Loa (eye worm)	hypothetical protein	0.002	0.007	0.0375
Toxoplasma gondii	non-specific serine/threonine protein kinase	0.0011	0.0008	0.0114
Echinococcus granulosus	rhodopsin orphan GPCR	0.0034	0.0166	0.0136
Echinococcus granulosus	g protein coupled receptor	0.0034	0.0166	0.0136
Echinococcus multilocularis	fmrfamide receptor	0.0034	0.0166	0.0136
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0034	0.0166	0.0166
Schistosoma mansoni	sex comb on midleg homolog	0.0048	0.0264	0.0264
Schistosoma mansoni	pyruvate kinase	0.0017	0.0048	0.0048
Echinococcus granulosus	ATP dependent DNA helicase Q1	0.002	0.007	0.004
Echinococcus granulosus	biogenic amine 5HT receptor	0.0034	0.0166	0.0136
Echinococcus multilocularis	sex peptide receptor	0.0034	0.0166	0.0136
Schistosoma mansoni	myosin xvIII	0.0034	0.0166	0.0166
Entamoeba histolytica	deoxycytidyl transferase, putative	0.0073	0.0444	0.7977
Toxoplasma gondii	Acetyl-coenzyme A synthetase 2, putative	0.0021	0.0078	0.1093
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0019	0.0063	0.0772
Trypanosoma cruzi	hypothetical protein, conserved	0.0023	0.0088	0.108
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0056	0.0766
Onchocerca volvulus		0.0034	0.0166	0.2024
Mycobacterium ulcerans	molybdopterin-guanine dinucleotide biosynthesis protein A	0.0104	0.0661	0.1547
Onchocerca volvulus		0.0034	0.0166	0.2024
Mycobacterium ulcerans	acyl-CoA synthetase	0.0021	0.0078	0.0039
Schistosoma mansoni	hypothetical protein	0.0034	0.0166	0.0166
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0034	0.0166	0.0136
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0034	0.0166	0.0136
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0029	0.0134	0.2025
Trypanosoma brucei	acetyl-CoA synthetase, putative	0.0021	0.0078	0.0291
Brugia malayi	RE15519p	0.0034	0.0166	0.0619
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0166	0.089
Brugia malayi	G protein-coupled receptor F59B2.13	0.0034	0.0166	0.0619
Loa Loa (eye worm)	MBCTL1	0.0054	0.031	0.1663
Mycobacterium ulcerans	acyl-CoA synthetase	0.0021	0.0078	0.0039
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0166	0.089
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0034	0.0166	0.0136
Schistosoma mansoni	DNA polymerase IV / kappa	0.0023	0.0088	0.0088
Leishmania major	pyruvate kinase	0.0033	0.0163	0.1411
Brugia malayi	Pyruvate kinase, M2 isozyme	0.0033	0.0163	0.06
Schistosoma mansoni	acetyl-CoA synthetase	0.0021	0.0078	0.0078
Leishmania major	acetyl-CoA synthetase, putative	0.0021	0.0078	0.0291
Mycobacterium leprae	Probable cytosol aminopeptidase PepB	0.011	0.0707	0.1635
Brugia malayi	hypothetical protein	0.0034	0.0166	0.0619
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0056	0.0766
Trichomonas vaginalis	conserved hypothetical protein	0.0013	0.0021	0.021
Brugia malayi	neuropeptide F receptor	0.0034	0.0166	0.0619
Echinococcus granulosus	pyruvate kinase	0.0017	0.0048	0.0018
Schistosoma mansoni	cpg binding protein	0.0059	0.0342	0.0342
Brugia malayi	hypothetical protein	0.0034	0.0166	0.0619
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0029	0.0134	0.2025
Schistosoma mansoni	neuropeptide receptor	0.0034	0.0166	0.0166
Trypanosoma cruzi	metallo-peptidase, Clan MF, Family M17	0.0022	0.0083	0.1018
Toxoplasma gondii	4'-phosphopantetheinyl transferase domain-containing protein	0.0023	0.0092	0.1293
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0034	0.0166	0.0136
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0034	0.0166	0.0136
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0166	0.089
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0019	0.0063	0.095
Brugia malayi	Aminopeptidase ZK353.6 in chromosome III	0.0022	0.0083	0.0158
Trypanosoma brucei	DNA polymerase kappa, putative	0.01	0.0632	0.7616
Schistosoma mansoni	amine GPCR	0.0034	0.0166	0.0166
Echinococcus multilocularis	geminin	0.0346	0.2376	0.2352
Schistosoma mansoni	aminoadipate-semialdehyde dehydrogenase	0.0083	0.0514	0.0514
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0034	0.0166	0.0136
Onchocerca volvulus		0.0034	0.0166	0.2024
Echinococcus granulosus	terminal deoxycytidyl transferase rev1	0.0073	0.0444	0.0415
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0013	0.0021	0.021
Trypanosoma cruzi	metallo-peptidase, Clan MF, Family M17	0.0022	0.0083	0.1018
Trypanosoma cruzi	cytosolic leucyl aminopeptidase, putative	0.011	0.0707	0.8705
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0021	0.0078	0.0039
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0073	0.0441	0.7909
Echinococcus multilocularis	dro:myosuppressin receptor	0.0034	0.0166	0.0136
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0166	0.089
Leishmania major	DNA polymerase eta, putative	0.0125	0.0812	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0043	0.0232	0.3596
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0018	0.0056	0.0025
Echinococcus granulosus	neuropeptides capa receptor	0.0034	0.0166	0.0136
Brugia malayi	putative neuropeptide receptor NPR1	0.0034	0.0166	0.0619
Loa Loa (eye worm)	G-protein coupled receptor	0.0034	0.0166	0.089
Trichomonas vaginalis	conserved hypothetical protein	0.0013	0.0021	0.021
Schistosoma mansoni	cpg binding protein	0.0062	0.0366	0.0366
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0018	0.0056	0.0688
Trichomonas vaginalis	PIKK family atypical protein kinase	0.004	0.0213	0.3278
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.0073	0.0444	0.2381
Echinococcus granulosus	neuropeptide receptor	0.0034	0.0166	0.0136
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0311	0.1665
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0311	0.1665
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0166	0.089
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0311	0.1665
Trypanosoma brucei	DNA damage repair protein, putative	0.0023	0.0088	0.042
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0034	0.0166	0.0166
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0013	0.0021	0.021
Brugia malayi	neuropeptide F receptor	0.0034	0.0166	0.0619
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0034	0.0166	0.0166
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0029	0.0134	0.2025
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0051	0.029	0.0602
Schistosoma mansoni	adenoreceptor	0.0034	0.0166	0.0166
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0048	0.0265	0.0236
Echinococcus granulosus	rhodopsin orphan GPCR	0.0034	0.0166	0.0136
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0019	0.0063	0.0015
Echinococcus granulosus	fmrfamide receptor	0.0034	0.0166	0.0136
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0073	0.0441	0.0978
Schistosoma mansoni	DNA helicase recq5	0.002	0.007	0.007
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0166	0.089
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0034	0.0166	0.0166
Echinococcus granulosus	pyruvate kinase	0.0033	0.0163	0.0133
Echinococcus multilocularis	pyruvate kinase	0.0017	0.0048	0.0018
Brugia malayi	AMP-binding enzyme family protein	0.0021	0.0078	0.0132
Schistosoma mansoni	leucine aminopeptidase	0.0022	0.0083	0.0083
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0166	0.089
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.0054	0.0311	0.3554
Brugia malayi	aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase	0.0083	0.0514	0.2538
Echinococcus multilocularis	neuropeptide receptor	0.0034	0.0166	0.0136
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0166	0.089
Schistosoma mansoni	pyruvate kinase	0.0033	0.0163	0.0163
Echinococcus multilocularis	pyruvate kinase	0.0026	0.0113	0.0083
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0104	0.0661	0.156
Mycobacterium ulcerans	pyruvate kinase	0.0033	0.0163	0.0259
Trypanosoma brucei	unspecified product	0.005	0.0284	0.3013
Echinococcus granulosus	rhodopsin orphan GPCR	0.0034	0.0166	0.0136
Echinococcus granulosus	histone acetyltransferase MYST2	0.0054	0.031	0.0281
Mycobacterium ulcerans	hypothetical protein	0.0073	0.0441	0.0978
Trypanosoma brucei	ATP-dependent DEAD/H DNA helicase recQ, putative	0.002	0.007	0.0186
Echinococcus granulosus	tm gpcr rhodopsin	0.0034	0.0166	0.0136
Schistosoma mansoni	hypothetical protein	0.0836	0.5837	0.5837
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0013	0.0021	0.021
Schistosoma mansoni	amine GPCR	0.0034	0.0166	0.0166
Giardia lamblia	DINP protein human, muc B family	0.008	0.0491	1
Toxoplasma gondii	eukaryotic initiation factor-2B, gamma subunit, putative	0.0104	0.0661	0.9259
Loa Loa (eye worm)	hypothetical protein	0.0125	0.0812	0.4353
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0166	0.089
Brugia malayi	Aminopeptidase W07G4.4 in chromosome V	0.0022	0.0083	0.0158
Echinococcus granulosus	sex peptide receptor	0.0034	0.0166	0.0136
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0073	0.0441	0.0978
Echinococcus granulosus	ATP dependent DNA helicase Q5	0.002	0.007	0.004
Schistosoma mansoni	neuropeptide F-like receptor	0.0034	0.0166	0.0166
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0034	0.0166	0.0136
Mycobacterium tuberculosis	Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0021	0.0078	0.0054
Trichomonas vaginalis	DNA helicase recq, putative	0.002	0.007	0.0992
Mycobacterium tuberculosis	Phenyloxazoline synthase MbtB (phenyloxazoline synthetase)	0.0021	0.0078	0.0054
Trichomonas vaginalis	PIKK family atypical protein kinase	0.004	0.0213	0.3278
Trypanosoma brucei	DNA polymerase kappa, putative	0.0057	0.033	0.3629
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0048	0.0265	0.1422
Onchocerca volvulus		0.0034	0.0166	0.2024
Toxoplasma gondii	ImpB/MucB/SamB family protein	0.0023	0.0088	0.123
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0078	0.0418
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0166	0.089
Trypanosoma brucei	metallo-peptidase, Clan MF, Family M17	0.0022	0.0083	0.0353
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0034	0.0166	0.0136
Trypanosoma brucei	phosphatidylinositol 3-kinase tor, putative	0.0026	0.0109	0.0698
Echinococcus granulosus	rhodopsin orphan GPCR	0.0034	0.0166	0.0136
Giardia lamblia	GTOR	0.0054	0.0311	0.5937
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0019	0.0063	0.0336
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0035	0.0176	0.2697
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0019	0.0063	0.0887
Trichomonas vaginalis	helicase, putative	0.0013	0.0021	0.021
Trypanosoma brucei	hypothetical protein, conserved	0.0023	0.0088	0.042
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0034	0.0166	0.0136
Schistosoma mansoni	DNA helicase recq1	0.002	0.007	0.007
Loa Loa (eye worm)	histone methyltransferase	0.0018	0.0056	0.0298
Plasmodium falciparum	ATP-dependent DNA helicase Q1	0.002	0.007	0.0333
Mycobacterium ulcerans	acyl-CoA synthetase	0.0021	0.0078	0.0039
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0034	0.0166	0.0136
Echinococcus multilocularis	endonuclease exonuclease phosphatase	0.0191	0.1281	0.1255
Mycobacterium ulcerans	4'-phosphopantetheinyl transferase	0.0023	0.0092	0.0076
Leishmania major	phosphopantetheinyl transferase-like protein	0.0023	0.0092	0.048
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.0054	0.0311	0.0311
Brugia malayi	AMP-binding enzyme family protein	0.0021	0.0078	0.0132
Brugia malayi	polk-prov protein	0.0049	0.0275	0.1222
Schistosoma mansoni	sex comb on midleg homolog	0.0048	0.0264	0.0264
Trypanosoma brucei	aminopeptidase, putative	0.0022	0.0083	0.0353
Toxoplasma gondii	AMP-binding enzyme domain-containing protein	0.0021	0.0078	0.1093
Toxoplasma gondii	propionate-CoA ligase	0.0021	0.0078	0.1093
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0034	0.0166	0.0136
Trypanosoma cruzi	hypothetical protein, conserved	0.0023	0.0088	0.108
Schistosoma mansoni	neuropeptide f receptor 76f	0.0034	0.0166	0.0166
Leishmania major	DNA polymerase kappa, putative,DNA polymerase IV, putative	0.008	0.0491	0.575
Onchocerca volvulus	Pyruvate kinase homolog	0.0033	0.0163	0.1942
Schistosoma mansoni	neuropeptide F-like receptor	0.0034	0.0166	0.0166
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0034	0.0166	0.0619
Echinococcus granulosus	rhodopsin orphan GPCR	0.0034	0.0166	0.0136
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0166	0.089
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0166	0.089
Echinococcus granulosus	neuropeptides capa receptor	0.0034	0.0166	0.0136
Echinococcus multilocularis	leucyl aminopeptidase	0.0022	0.0083	0.0053
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0166	0.089
Mycobacterium tuberculosis	Probable peptide synthetase Nrp (peptide synthase)	0.0021	0.0078	0.0054
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0163	0.0871
Brugia malayi	hypothetical protein	0.0034	0.0166	0.0619
Trichomonas vaginalis	ap endonuclease, putative	0.0019	0.0063	0.0875
Loa Loa (eye worm)	melatonin receptor type 1A	0.0034	0.0166	0.089
Loa Loa (eye worm)	aminopeptidase in chromosome V	0.0022	0.0083	0.0443
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0034	0.0166	0.0136
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0166	0.089
Leishmania major	aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17	0.0022	0.0083	0.0353
Onchocerca volvulus		0.0034	0.0166	0.2024
Schistosoma mansoni	histamine h1 receptor	0.0034	0.0166	0.0166
Leishmania major	aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17	0.0022	0.0083	0.0353
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0021	0.0078	0.0054
Trypanosoma cruzi	DNA damage repair protein, putative	0.0023	0.0088	0.108
Trypanosoma brucei	FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative	0.0023	0.0087	0.0406
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0046	0.0255	0.3955
Mycobacterium tuberculosis	Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed))	0.008	0.0491	0.1122
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0166	0.089
Loa Loa (eye worm)	G-protein coupled receptor	0.0034	0.0166	0.089
Leishmania major	aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17	0.0022	0.0083	0.0353
Trichomonas vaginalis	DNA polymerase eta, putative	0.01	0.0632	1
Echinococcus granulosus	allatostatin A receptor	0.0034	0.0166	0.0136
Brugia malayi	AMP-binding enzyme family protein	0.0073	0.0441	0.2133
Echinococcus granulosus	tm gpcr rhodopsin	0.0034	0.0166	0.0136
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0034	0.0166	0.0166
Brugia malayi	CXXC zinc finger family protein	0.0059	0.0342	0.159
Trichomonas vaginalis	conserved hypothetical protein	0.0013	0.0021	0.021
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0166	0.089
Mycobacterium ulcerans	acyl-CoA synthetase	0.0021	0.0078	0.0039
Echinococcus granulosus	endonuclease exonuclease phosphatase	0.0191	0.1281	0.1255
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0048	0.0265	0.0265
Trichomonas vaginalis	PIKK family atypical protein kinase	0.004	0.0213	0.3278
Trypanosoma brucei	unspecified product	0.005	0.0284	0.3013
Schistosoma mansoni	opsin-like receptor	0.0034	0.0166	0.0166
Echinococcus granulosus	dual specificity	0.0089	0.0557	0.0528
Entamoeba histolytica	protein kinase, putative	0.0089	0.0557	1
Echinococcus granulosus	pyruvate kinase	0.0017	0.0048	0.0018
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	0.0054	0.0311	0.0282
Trypanosoma cruzi	DNA damage repair protein, putative	0.0023	0.0088	0.108
Plasmodium vivax	DNA repair protein REV1, putative	0.0023	0.0088	0.1241
Mycobacterium ulcerans	acyl-CoA synthetase	0.0021	0.0078	0.0039
Loa Loa (eye worm)	neuropeptide F receptor	0.0034	0.0166	0.089
Echinococcus granulosus	cpg binding protein	0.0062	0.0366	0.0337
Trypanosoma cruzi	DNA polymerase eta, putative	0.0075	0.0456	0.561
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0034	0.0166	0.2024
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0091	0.049
Echinococcus multilocularis	dna polymerase kappa	0.01	0.0632	0.0604
Schistosoma mansoni	hypothetical protein	0.0346	0.2376	0.2376
Trypanosoma brucei	hypothetical protein, conserved	0.0023	0.0088	0.042
Loa Loa (eye worm)	pyruvate kinase	0.0033	0.0163	0.0871
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0029	0.0134	0.202
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0034	0.0166	0.0166
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0034	0.0166	0.0136
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0036	0.0185	0.283
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0013	0.0021	0.021
Trichomonas vaginalis	antibiotic synthetase, putative	0.0021	0.0078	0.1119
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0166	0.089
Onchocerca volvulus	Pyruvate kinase homolog	0.0033	0.0163	0.1942
Brugia malayi	ImpB/MucB/SamB family protein	0.0125	0.0812	0.4185
Mycobacterium ulcerans	DNA polymerase IV	0.01	0.0632	0.1474
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0054	0.0311	0.1418
Echinococcus multilocularis	pyruvate kinase	0.0033	0.0163	0.0133
Mycobacterium tuberculosis	Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0021	0.0078	0.0054
Brugia malayi	C2-HC type zinc finger protein C.e-MyT1	0.0054	0.031	0.1415
Mycobacterium tuberculosis	Peptide synthetase MbtF (peptide synthase)	0.0021	0.0078	0.0054
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0013	0.0021	0.021
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0032	0.0154	0.2343
Toxoplasma gondii	leucyl aminopeptidase LAP	0.011	0.0707	0.9914
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0166	0.089
Brugia malayi	sulfakinin receptor protein	0.0034	0.0166	0.0619
Mycobacterium tuberculosis	Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU	0.0565	0.3926	1
Onchocerca volvulus	Pyruvate kinase homolog	0.0033	0.0163	0.1942
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0034	0.0166	0.0166
Loa Loa (eye worm)	hypothetical protein	0.0089	0.0554	0.2967
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	0.0054	0.0311	0.3828
Trypanosoma brucei	DNA polymerase IV, putative	0.01	0.0632	0.7616
Leishmania major	DNA polymerase kappa, putative	0.008	0.0491	0.575
Echinococcus granulosus	hypothetical protein	0.0034	0.0166	0.0136
Schistosoma mansoni	amine GPCR	0.0034	0.0166	0.0166
Treponema pallidum	licC protein (licC)	0.0104	0.0661	1
Trichomonas vaginalis	pyruvate kinase, putative	0.0033	0.0163	0.2477
Echinococcus multilocularis	polycomb protein SCMH1	0.0048	0.0264	0.0234
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0441	0.2361
Trypanosoma brucei	pyruvate kinase 1, putative	0.0033	0.0163	0.1411
Loa Loa (eye worm)	phosphatidylinositol 3	0.0054	0.0311	0.1666
Chlamydia trachomatis	pyruvate kinase	0.0033	0.0163	0.1145
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0274	0.1866	1
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0034	0.0166	0.0166
Trypanosoma brucei	DNA polymerase kappa, putative	0.01	0.0632	0.7616
Onchocerca volvulus		0.0073	0.0441	0.8317
Loa Loa (eye worm)	mbt repeat family protein	0.0048	0.0264	0.1414
Trypanosoma brucei	DNA polymerase kappa, putative	0.01	0.0632	0.7616
Toxoplasma gondii	target of rapamycin (TOR), putative	0.004	0.0213	0.2981
Brugia malayi	AMP-binding enzyme family protein	0.0021	0.0078	0.0132
Echinococcus multilocularis	neuropeptide Y receptor	0.0034	0.0166	0.0136
Echinococcus multilocularis	somatostatin receptor	0.0034	0.0166	0.0136
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.002	0.007	0.0981
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0034	0.0166	0.0136
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0056	0.0766
Echinococcus granulosus	orexin receptor type 2	0.0034	0.0166	0.0136
Schistosoma mansoni	ap endonuclease	0.0019	0.0063	0.0063
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0034	0.0166	0.0136
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0073	0.0441	0.0942
Leishmania major	pyruvate kinase	0.0033	0.0163	0.1411
Plasmodium vivax	pyruvate kinase 2, putative	0.0017	0.0048	0.068
Trypanosoma cruzi	acetyl-CoA synthetase, putative	0.0021	0.0078	0.0959
Schistosoma mansoni	serine/threonine protein kinase	0.0089	0.0557	0.0557
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0032	0.0154	0.2343
Mycobacterium ulcerans	hypothetical protein	0.0104	0.0661	0.1547
Mycobacterium tuberculosis	Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase	0.0021	0.0078	0.0054
Schistosoma mansoni	hypothetical protein	0.0346	0.2376	0.2376
Loa Loa (eye worm)	hypothetical protein	0.0083	0.0514	0.2754
Brugia malayi	mbt repeat family protein	0.0048	0.0264	0.1158
Loa Loa (eye worm)	CMGC/DYRK/DYRK1 protein kinase	0.0089	0.0557	0.2985
Echinococcus multilocularis	dual specificity	0.0089	0.0557	0.0528
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0034	0.0166	0.0166
Trypanosoma cruzi	DNA polymerase kappa, putative	0.01	0.0632	0.778
Entamoeba histolytica	pyruvate kinase, putative	0.0023	0.0091	0.1641
Toxoplasma gondii	BRCA1 C Terminus (BRCT) domain-containing protein	0.0029	0.0134	0.1883
Schistosoma mansoni	amine GPCR	0.0034	0.0166	0.0166
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0034	0.0166	0.0136
Echinococcus granulosus	polycomb protein SCMH1	0.0048	0.0264	0.0234
Schistosoma mansoni	opsin-like receptor	0.0034	0.0166	0.0166
Echinococcus granulosus	neuropeptide Y receptor	0.0034	0.0166	0.0136
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0054	0.0311	0.0656
Echinococcus granulosus	SAM and MBT domain containing protein	0.0048	0.0264	0.0234
Brugia malayi	AMP-binding enzyme family protein	0.0021	0.0078	0.0132
Schistosoma mansoni	opsin-like receptor	0.0034	0.0166	0.0166
Trypanosoma cruzi	pyruvate kinase 2, putative	0.0033	0.0163	0.2002
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0441	0.2361
Trichomonas vaginalis	conserved hypothetical protein	0.0013	0.0021	0.021
Trypanosoma brucei	DNA polymerase kappa, putative	0.0057	0.033	0.3629
Onchocerca volvulus		0.0034	0.0166	0.2024
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0034	0.0166	0.0166
Loa Loa (eye worm)	pyruvate kinase-PB	0.0023	0.0091	0.049
Onchocerca volvulus		0.0034	0.0166	0.2024
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0034	0.0166	0.0166
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0034	0.0166	0.0166
Echinococcus multilocularis	histone acetyltransferase MYST2	0.0054	0.031	0.0281
Echinococcus granulosus	dro:myosuppressin receptor	0.0034	0.0166	0.0136
Brugia malayi	ATP-dependent DNA helicase, RecQ family protein	0.002	0.007	0.0089
Loa Loa (eye worm)	hypothetical protein	0.0054	0.031	0.1663
Trypanosoma brucei	CMGC/DYRK protein kinase, putative	0.0089	0.0557	0.6624
Echinococcus granulosus	leucyl aminopeptidase	0.0022	0.0083	0.0053
Trypanosoma cruzi	CMGC/DYRK protein kinase, putative	0.0089	0.0557	0.6857
Schistosoma mansoni	PwLAP aminopeptidase (M17 family)	0.0022	0.0083	0.0083
Mycobacterium tuberculosis	Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase)	0.0021	0.0078	0.0054
Echinococcus granulosus	7tm_1 domain containing protein	0.0034	0.0166	0.0136
Leishmania major	long-chain-fatty-acid-CoA ligase, putative	0.0021	0.0078	0.0291
Mycobacterium tuberculosis	Probable pyruvate kinase PykA	0.0033	0.0163	0.0273
Echinococcus multilocularis	leucyl aminopeptidase	0.0022	0.0083	0.0053
Trypanosoma brucei	DNA polymerase kappa, putative	0.01	0.0632	0.7616
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0019	0.0063	0.0033
Echinococcus granulosus	biogenic amine 5HT receptor	0.0034	0.0166	0.0136
Trypanosoma brucei	DNA polymerase kappa, putative	0.01	0.0632	0.7616
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0264	0.1414
Brugia malayi	G-protein coupled receptor	0.0034	0.0166	0.0619
Mycobacterium ulcerans	leucyl aminopeptidase	0.011	0.0707	0.1668
Schistosoma mansoni	terminal deoxycytidyl transferase	0.0073	0.0444	0.0444
Echinococcus granulosus	pyruvate kinase	0.0017	0.0048	0.0018
Giardia lamblia	Pyruvate kinase	0.0033	0.0163	0.2587
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0051	0.029	0.0602
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0032	0.0157	0.2379
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0166	0.089
Echinococcus granulosus	somatostatin receptor	0.0034	0.0166	0.0136
Entamoeba histolytica	long-chain-fatty-acid--CoA ligase, putative	0.0021	0.0078	0.1399
Echinococcus multilocularis	g protein coupled receptor	0.0034	0.0166	0.0136
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0034	0.0166	0.0136
Brugia malayi	GnHR receptor homolog	0.0034	0.0166	0.0619
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0054	0.0311	0.4855
Schistosoma mansoni	phosphatidylinositol 3-and 4-kinase	0.0018	0.0056	0.0056
Brugia malayi	mbt repeat family protein	0.0048	0.0264	0.1158
Onchocerca volvulus		0.0034	0.0166	0.2024
Entamoeba histolytica	hypothetical protein	0.0089	0.0557	1
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0019	0.0063	0.0033
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0019	0.0063	0.0772
Echinococcus multilocularis	pyruvate kinase	0.0017	0.0048	0.0018
Wolbachia endosymbiont of Brugia malayi	leucyl aminopeptidase	0.011	0.0707	0.1668
Entamoeba histolytica	hypothetical protein	0.0023	0.0092	0.1656
Brugia malayi	acetyl-Coenzyme A synthetase 2	0.0021	0.0078	0.0132
Echinococcus granulosus	dna polymerase kappa	0.01	0.0632	0.0604
Echinococcus multilocularis	SAM and MBT domain containing protein	0.0048	0.0264	0.0234
Trichomonas vaginalis	conserved hypothetical protein	0.0013	0.0021	0.021
Echinococcus multilocularis	L aminoadipate semialdehyde	0.0083	0.0514	0.0485
Echinococcus granulosus	neuropeptide FF receptor 2	0.0034	0.0166	0.0136
Echinococcus granulosus	leucine aminopeptidase protein	0.011	0.0707	0.0679
Echinococcus multilocularis	suppression of tumorigenicity 18 protein	0.0054	0.031	0.0281
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0034	0.0166	0.089
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0029	0.0134	0.2025
Echinococcus granulosus	bloom syndrome protein	0.002	0.007	0.004
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0034	0.0166	0.0136
Toxoplasma gondii	ImpB/MucB/SamB family protein	0.0075	0.0456	0.6389
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0166	0.089
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0034	0.0166	0.0136
Trypanosoma cruzi	CMGC/DYRK protein kinase, putative	0.0089	0.0557	0.6857
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0166	0.089
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0034	0.0166	0.0166
Echinococcus multilocularis	fmrfamide receptor	0.0034	0.0166	0.0136
Mycobacterium ulcerans	acyl-CoA synthetase	0.0073	0.0441	0.0978
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	0.0022	0.0083	0.0158
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0034	0.0166	0.0136
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0043	0.0232	0.3596
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0029	0.0134	0.202
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0048	0.0265	0.0236
Mycobacterium ulcerans	O-succinylbenzoic acid--CoA ligase	0.0021	0.0078	0.0039
Toxoplasma gondii	pyruvate kinase PyK1	0.0033	0.0163	0.228
Loa Loa (eye worm)	ATP-dependent DNA helicase	0.002	0.007	0.0375
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0034	0.0166	0.0166
Schistosoma mansoni	neuropeptide receptor	0.0034	0.0166	0.0166
Trypanosoma brucei	DNA polymerase IV, putative	0.0093	0.0586	0.7
Schistosoma mansoni	scm-relatedprotein containing 4 mbt domains (sfmbt)	0.0048	0.0264	0.0264
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0166	0.089
Brugia malayi	ORL1-like opioid receptor	0.0034	0.0166	0.0619
Mycobacterium ulcerans	acyl-CoA synthetase	0.0073	0.0441	0.0978
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0166	0.089
Mycobacterium ulcerans	non-ribosomal peptide synthetase MbtE	0.0021	0.0078	0.0039
Echinococcus multilocularis	cpg binding protein	0.0062	0.0366	0.0337
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0104	0.0661	0.156
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0166	0.089
Plasmodium falciparum	holo-[acyl-carrier-protein] synthase, putative	0.0023	0.0092	0.067
Onchocerca volvulus		0.0034	0.0166	0.2024
Brugia malayi	Dopamine receptor protein 1	0.0034	0.0166	0.0619
Onchocerca volvulus	Polycomb protein Sfmbt homolog	0.0048	0.0264	0.4264
Mycobacterium ulcerans	acyl-CoA synthetase	0.0021	0.0078	0.0039
Echinococcus granulosus	dnaJ subfamily B	0.0836	0.5837	0.5825
Loa Loa (eye worm)	hypothetical protein	0.001	0.000000000058882	0.00000000031548
Echinococcus multilocularis	G protein coupled receptor 139	0.0034	0.0166	0.0136
Trypanosoma brucei	pyruvate kinase 1	0.0033	0.0163	0.1411
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0166	0.089
Mycobacterium tuberculosis	Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0021	0.0078	0.0054
Schistosoma mansoni	biogenic amine receptor	0.0034	0.0166	0.0166
Leishmania major	DNA polymerase eta, putative	0.0075	0.0456	0.5285
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0166	0.089
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0032	0.0157	0.2379
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0034	0.0166	0.0136
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0032	0.0157	0.2379
Trichomonas vaginalis	conserved hypothetical protein	0.0013	0.0021	0.021
Echinococcus granulosus	neuropeptide s receptor	0.0034	0.0166	0.0136
Echinococcus multilocularis	leucyl aminopeptidase	0.0022	0.0083	0.0053
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0034	0.0166	0.0619
Toxoplasma gondii	pyruvate kinase PyKII	0.0017	0.0048	0.0674
Entamoeba histolytica	recQ family helicase, putative	0.002	0.007	0.1257
Plasmodium falciparum	acyl-CoA synthetase	0.0054	0.0311	0.3986
Leishmania major	serine/threonine-protein kinase, putative,protein kinase, putative	0.0089	0.0557	0.6624
Trichomonas vaginalis	conserved hypothetical protein	0.0013	0.0021	0.021
Mycobacterium tuberculosis	holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie	0.0023	0.0092	0.0091
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0034	0.0166	0.0166
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0048	0.0265	0.0236
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0034	0.0166	0.0166
Brugia malayi	hypothetical protein	0.0034	0.0166	0.0619
Trypanosoma cruzi	DNA polymerase eta, putative	0.0125	0.0812	1
Loa Loa (eye worm)	phosphatidylinositol 3	0.0018	0.0056	0.03
Trypanosoma brucei	metallo-peptidase, Clan MF, Family M17	0.0022	0.0083	0.0353
Trypanosoma cruzi	DNA polymerase kappa, putative	0.01	0.0632	0.778
Brugia malayi	Dopamine receptor protein 2	0.0034	0.0166	0.0619
Brugia malayi	hypothetical protein	0.0034	0.0166	0.0619
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0166	0.089
Schistosoma mansoni	hypothetical protein	0.0034	0.0166	0.0166
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	0.0054	0.0311	0.0282
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.002	0.007	0.0981
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0166	0.089
Echinococcus granulosus	neuropeptide Y receptor	0.0034	0.0166	0.0136
Brugia malayi	AKH receptor	0.0034	0.0166	0.0619
Brugia malayi	hypothetical protein	0.0034	0.0166	0.0619
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0034	0.0166	0.0166
Loa Loa (eye worm)	pyruvate kinase	0.0033	0.0163	0.0871
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0034	0.0166	0.0166
Mycobacterium ulcerans	phosphopantetheinyl transferase, PptII	0.0023	0.0092	0.0076
Leishmania major	target of rapamycin (TOR) kinase 2, putative	0.0054	0.0311	0.3372
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0013	0.0021	0.021
Echinococcus granulosus	geminin	0.0346	0.2376	0.2352
Echinococcus multilocularis	neuropeptides capa receptor	0.0034	0.0166	0.0136
Entamoeba histolytica	protein kinase domain containing protein	0.0089	0.0557	1
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0005	0.0029
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0073	0.0444	0.1001
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0034	0.0166	0.0136
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0008	0.0043
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0073	0.0441	0.7909
Mycobacterium ulcerans	acyl-CoA synthetase	0.0021	0.0078	0.0039
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0034	0.0166	0.0166
Trypanosoma brucei	DNA polymerase kappa, putative	0.0049	0.0275	0.2901
Plasmodium vivax	acetyl-CoA synthetase, putative	0.0021	0.0078	0.1102
Echinococcus granulosus	7TM GPCR rhodopsin	0.0034	0.0166	0.0136
Brugia malayi	Protein kinase domain containing protein	0.0089	0.0557	0.2776
Echinococcus granulosus	rhodopsin orphan GPCR	0.0034	0.0166	0.0136
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0054	0.0311	0.0642
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0034	0.0166	0.0166
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0029	0.0134	0.202
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0311	0.1665
Onchocerca volvulus		0.0034	0.0166	0.2024
Trypanosoma cruzi	metallo-peptidase, Clan MF, Family M17, putative	0.011	0.0707	0.8705
Trypanosoma brucei	chrX additional, unordered contigs	0.0023	0.0088	0.042
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0166	0.089
Schistosoma mansoni	growth hormone secretagogue receptor	0.0034	0.0166	0.0166
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0051	0.029	0.0602
Trypanosoma brucei	DNA polymerase IV, putative	0.01	0.0632	0.7616
Echinococcus granulosus	tm gpcr rhodopsin	0.0034	0.0166	0.0136
Trichomonas vaginalis	DNA helicase recq, putative	0.002	0.007	0.0992
Loa Loa (eye worm)	hypothetical protein	0.0089	0.0554	0.2967
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0166	0.089
Mycobacterium ulcerans	bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase	0.0021	0.0078	0.0039
Echinococcus granulosus	pyruvate kinase	0.0033	0.0163	0.0133
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0166	0.089
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0034	0.0166	0.0619
Schistosoma mansoni	cpg binding protein	0.0062	0.0366	0.0366
Echinococcus granulosus	G protein coupled receptor 139	0.0034	0.0166	0.0136
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0019	0.0063	0.0222
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0166	0.089
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0018	0.0056	0.0011
Wolbachia endosymbiont of Brugia malayi	4'-phosphopantetheinyl transferase	0.0023	0.0092	0.0076
Trypanosoma brucei	hypothetical protein, conserved	0.0023	0.0092	0.048
Echinococcus multilocularis	dnaJ subfamily B	0.0836	0.5837	0.5825
Plasmodium falciparum	M17 leucyl aminopeptidase	0.011	0.0707	1
Giardia lamblia	Sgs1 DNA helicase, putative	0.002	0.007	0.0496
Onchocerca volvulus		0.0034	0.0166	0.2024
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0073	0.0441	0.0942
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0051	0.029	0.0602
Schistosoma mansoni	DNA polymerase eta	0.0125	0.0812	0.0812
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0034	0.0166	0.0136
Echinococcus multilocularis	allatostatin A receptor	0.0034	0.0166	0.0136
Brugia malayi	follicle stimulating hormone receptor	0.0274	0.1866	1
Leishmania major	4-coumarate:coa ligase-like protein	0.0073	0.0441	0.5084
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0043	0.0232	0.3596
Trypanosoma brucei	DNA polymerase eta, putative	0.0125	0.0812	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0048	0.0265	0.0265
Echinococcus granulosus	serotonin receptor	0.0034	0.0166	0.0136
Echinococcus multilocularis	ATP dependent DNA helicase Q1	0.002	0.007	0.004
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0034	0.0166	0.0619
Echinococcus granulosus	L aminoadipate semialdehyde	0.0083	0.0514	0.0485
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0019	0.0063	0.1126
Echinococcus multilocularis	leucine aminopeptidase protein	0.011	0.0707	0.0679
Mycobacterium ulcerans	DNA polymerase IV	0.01	0.0632	0.1474
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0015	0.003	0.003
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0166	0.089
Trichomonas vaginalis	DNA polymerase IV / kappa, putative	0.01	0.0632	1
Brugia malayi	G protein-coupled receptor	0.0034	0.0166	0.0619
Mycobacterium ulcerans	peptide synthetase Nrp (peptide synthase)	0.0021	0.0078	0.0039
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0034	0.0166	0.0166
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0019	0.0063	0.0331
Trichomonas vaginalis	antibiotic synthetase, putative	0.0021	0.0078	0.1119
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0013	0.0021	0.021
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0043	0.0232	0.3596
Mycobacterium ulcerans	long-chain-acyl-CoA synthetase	0.0021	0.0078	0.0039
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0441	0.2361
Onchocerca volvulus		0.0048	0.0264	0.4264
Trypanosoma cruzi	DNA polymerase kappa, putative	0.01	0.0632	0.778
Echinococcus multilocularis	neuropeptides capa receptor	0.0034	0.0166	0.0136
Brugia malayi	putative neuropeptide receptor	0.0034	0.0166	0.0619
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0034	0.0166	0.089
Plasmodium falciparum	pyruvate kinase	0.0033	0.0163	0.1738
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0034	0.0166	0.0619
Echinococcus granulosus	acetyl coenzyme A synthetase cytoplasmic	0.0021	0.0078	0.0048
Echinococcus multilocularis	neuropeptide receptor	0.0034	0.0166	0.0136
Echinococcus granulosus	rhodopsin orphan GPCR	0.0034	0.0166	0.0136
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0048	0.0265	0.0265
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.0073	0.0444	0.0444
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0054	0.0311	0.3372
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0034	0.0166	0.0166
Brugia malayi	exodeoxyribonuclease III family protein	0.0019	0.0063	0.0048
Brugia malayi	Serotonin receptor	0.0034	0.0166	0.0619
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0048	0.0265	0.0236
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0056	0.0766
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0124	0.0807	0.0807
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0073	0.0441	0.0991
Chlamydia trachomatis	cytosol aminopeptidase	0.011	0.0707	1
Schistosoma mansoni	neuropeptide receptor	0.0034	0.0166	0.0166
Schistosoma mansoni	amine GPCR	0.0034	0.0166	0.0166
Echinococcus multilocularis	neuropeptide Y receptor	0.0034	0.0166	0.0136
Mycobacterium tuberculosis	P-hydroxybenzoyl-AMP ligase FadD22	0.0021	0.0078	0.0054

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (binding)	= 2.8184 um	PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ]	ChEMBL.	No reference
Potency (functional)	13.0918 uM	PUBCHEM_BIOASSAY: Acumen qHTS Assay for Inhibitors of the mTORC1 Signaling Pathway in MEF (Tsc2-/-, p53-/-) Cells: Sytravon. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2660, AID2666, AID2667, AID2668, AID2681, AID504465]	ChEMBL.	No reference
Potency (functional)	23.2809 uM	PUBCHEM_BIOASSAY: IN Cell qHTS Assay for Inhibitors of the mTORC1 Signaling Pathway in MEF (Tsc2-/-, p53-/-) Cells: Sytravon. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2660, AID2666, AID2667, AID2668, AID2681, AID493208]	ChEMBL.	No reference
Potency (functional)	23.9341 uM	PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411]	ChEMBL.	No reference
Potency (functional)	35.4813 uM	PubChem BioAssay. qHTS Assay to Identify Small Molecule Activators of BRCA1 Expression. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	39.8107 uM	PubChem BioAssay. A Novel Cell-Based Assay to Identify Small Molecules for B -Galactocerebrosidase. (Class of assay: confirmatory)	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1473441
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Bibliographic References

No literature references available for this target.

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Detailed information for compound 695313