Detailed information for compound 700000

Basic information

Technical information
  • TDR Targets ID: 700000
  • Name: N-[4,5-dimethyl-3-(methylcarbamoyl)thiophen-2 -yl]-2,3-dihydro-1,4-benzodioxine-2-carboxami de
  • MW: 346.401 | Formula: C17H18N2O4S
  • H donors: 2 H acceptors: 2 LogP: 3.18 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CNC(=O)c1c(NC(=O)C2COc3c(O2)cccc3)sc(c1C)C
  • InChi: 1S/C17H18N2O4S/c1-9-10(2)24-17(14(9)16(21)18-3)19-15(20)13-8-22-11-6-4-5-7-12(11)23-13/h4-7,13H,8H2,1-3H3,(H,18,21)(H,19,20)
  • InChiKey: ZPOQQRYZFGANMP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[4,5-dimethyl-3-(methylcarbamoyl)-2-thienyl]-2,3-dihydro-1,4-benzodioxine-2-carboxamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0024 0.0051 0.0092
Plasmodium falciparum threonine--tRNA ligase 0.0025 0.0053 0.0032
Plasmodium falciparum proline--tRNA ligase 0.0153 0.075 0.073
Schistosoma mansoni pyruvate kinase 0.0037 0.0118 0.0255
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0163 0.0806 0.9954
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0194 0.0974 0.21
Trichomonas vaginalis pyruvate kinase, putative 0.0037 0.0118 0.0516
Trichomonas vaginalis D-aminoacylase, putative 0.0041 0.0143 0.0622
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0131 0.0632 0.2754
Entamoeba histolytica hypothetical protein 0.0113 0.0533 0.2425
Trichomonas vaginalis sugar transporter, putative 0.0062 0.0253 0.1104
Onchocerca volvulus 0.0062 0.0253 0.2286
Schistosoma mansoni pyruvate kinase 0.0037 0.0118 0.0255
Schistosoma mansoni sugar transporter 0.0062 0.0253 0.0546
Mycobacterium ulcerans thioredoxin reductase TrxB2 0.0164 0.0809 1
Toxoplasma gondii LsmAD domain-containing protein 0.0054 0.0213 0.0289
Loa Loa (eye worm) hypothetical protein 0.0062 0.0253 0.0973
Entamoeba histolytica pyruvate kinase, putative 0.0026 0.0058 0.0094
Brugia malayi hypothetical protein 0.0062 0.0253 0.0973
Trichomonas vaginalis conserved hypothetical protein 0.0437 0.2294 1
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0037 0.0163
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0437 0.2294 0.4133
Onchocerca volvulus 0.0062 0.0253 0.2286
Echinococcus granulosus synaptic vesicle 2 protein 0.0062 0.0253 0.0456
Trichomonas vaginalis sugar transporter, putative 0.0062 0.0253 0.1104
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0062 0.0253 0.0546
Echinococcus multilocularis glycyl tRNA synthetase 0.0025 0.0053 0.0095
Toxoplasma gondii PHD-finger domain-containing protein 0.0035 0.0108 0.0131
Loa Loa (eye worm) hypothetical protein 0.0152 0.0744 0.2858
Echinococcus multilocularis pyruvate kinase 0.0019 0.0022 0.0039
Trichomonas vaginalis sugar transporter, putative 0.0136 0.0656 0.2859
Loa Loa (eye worm) hypothetical protein 0.0026 0.0058 0.0224
Trichomonas vaginalis sugar transporter, putative 0.0062 0.0253 0.1104
Trypanosoma cruzi PAB1-binding protein , putative 0.0054 0.0213 0.2837
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0134 0.0647 0.0627
Echinococcus granulosus intermediate filament protein 0.0082 0.0366 0.0659
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0153 0.075 1
Brugia malayi hypothetical protein 0.0035 0.0109 0.0418
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0111 0.0482
Loa Loa (eye worm) hypothetical protein 0.0062 0.0253 0.0973
Leishmania major hypothetical protein, conserved 0.0022 0.0037 0.0499
Schistosoma mansoni transient receptor potential channel 4 0.0216 0.1091 0.2351
Loa Loa (eye worm) hypothetical protein 0.0494 0.2603 1
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0098 0.045 0.534
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0081 0.0351
Leishmania major glucose transporter/membrane transporter D2, putative 0.0136 0.0656 0.8746
Trypanosoma brucei DNA polymerase IV, putative 0.0022 0.0039 0.0522
Onchocerca volvulus 0.0062 0.0253 0.2286
Plasmodium falciparum ataxin-2 like protein, putative 0.0054 0.0213 0.0192
Brugia malayi Cam kinase protein 1 0.0134 0.0647 0.2485
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0098 0.0428
Brugia malayi hypothetical protein 0.0062 0.0253 0.0973
Brugia malayi hypothetical protein 0.0494 0.2603 1
Trypanosoma brucei glucose transporter, putative 0.0136 0.0656 0.8746
Echinococcus multilocularis musashi 0.0082 0.0366 0.0659
Toxoplasma gondii transporter, major facilitator family protein 0.0062 0.0253 0.0351
Brugia malayi Sugar transporter family protein 0.0062 0.0253 0.0973
Brugia malayi follicle stimulating hormone receptor 0.0224 0.1138 0.4372
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0035 0.0108 0.0233
Trypanosoma cruzi sugar transporter, putative 0.0062 0.0253 0.3378
Onchocerca volvulus Pyruvate kinase homolog 0.0037 0.0118 0.0164
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0163 0.0806 0.9954
Echinococcus multilocularis solute carrier family 22 0.0062 0.0253 0.0456
Loa Loa (eye worm) PHD-finger family protein 0.0035 0.0108 0.0415
Loa Loa (eye worm) MH1 domain-containing protein 0.0018 0.0016 0.0062
Echinococcus granulosus survival motor neuron protein 1 0.0494 0.2603 0.4688
Schistosoma mansoni sugar transporter 0.0062 0.0253 0.0546
Echinococcus granulosus lamin 0.0082 0.0366 0.0659
Loa Loa (eye worm) major facilitator superfamily transporter 0.0062 0.0253 0.0973
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0437 0.2294 0.4133
Toxoplasma gondii ABC1 family protein 0.0041 0.0143 0.0184
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0098 0.0428
Trichomonas vaginalis sugar transporter, putative 0.0062 0.0253 0.1104
Brugia malayi ImpB/MucB/SamB family protein 0.0022 0.0039 0.015
Toxoplasma gondii lysine-tRNA ligase 0.0098 0.045 0.0648
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0041 0.0143 0.1366
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0131 0.0632 0.1362
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0044 0.0159 0.0609
Loa Loa (eye worm) hypothetical protein 0.008 0.0355 0.1365
Schistosoma mansoni glycyl-tRNA synthetase 0.0025 0.0053 0.0114
Schistosoma mansoni hypothetical protein 0.087 0.4641 1
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0437 0.2294 0.4133
Echinococcus multilocularis General substrate transporter 0.0376 0.1961 0.3531
Trichomonas vaginalis sugar transporter, putative 0.0062 0.0253 0.1104
Loa Loa (eye worm) hypothetical protein 0.0216 0.1091 0.4193
Mycobacterium leprae Probable lipase LipE 0.0041 0.0143 0.1366
Trichomonas vaginalis sugar transporter, putative 0.0062 0.0253 0.1104
Trichomonas vaginalis sugar transporter, putative 0.0062 0.0253 0.1104
Onchocerca volvulus 0.0041 0.0143 0.0548
Trichomonas vaginalis myo-inositol transporter, putative 0.0062 0.0253 0.1104
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0044 0.016 0.2131
Loa Loa (eye worm) hypothetical protein 0.0129 0.0622 0.2389
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0334 0.1733 0.7555
Trypanosoma brucei PAB1-binding protein , putative 0.0054 0.0213 0.2837
Loa Loa (eye worm) hypothetical protein 0.0062 0.0253 0.0973
Loa Loa (eye worm) hypothetical protein 0.0041 0.0143 0.0549
Trypanosoma cruzi PAB1-binding protein , putative 0.0054 0.0213 0.2837
Echinococcus multilocularis dna polymerase eta 0.0022 0.0039 0.0071
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0037 0.0118 0.0619
Loa Loa (eye worm) phosphatidylinositol 3 0.0044 0.016 0.0614
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0125 0.0543
Plasmodium vivax sugar transporter, putative 0.0062 0.0253 0.0232
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0075 0.0329
Echinococcus multilocularis pyruvate kinase 0.0029 0.0076 0.0138
Brugia malayi hypothetical protein 0.0054 0.0213 0.0817
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0131 0.0632 0.2428
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0041 0.0143 0.0805
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0134 0.0647 0.1165
Giardia lamblia Lysyl-tRNA synthetase 0.0098 0.045 0.2082
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0134 0.0647 0.2485
Onchocerca volvulus 0.0062 0.0253 0.2286
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0153 0.075 1
Echinococcus multilocularis smad 0.0018 0.0016 0.0029
Echinococcus multilocularis mothers against decapentaplegic 5 0.0018 0.0016 0.0029
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0098 0.0428
Echinococcus granulosus PHD finger protein rhinoceros 0.0035 0.0108 0.0195
Brugia malayi MH1 domain containing protein 0.0018 0.0016 0.0062
Brugia malayi PHD-finger family protein 0.0035 0.0108 0.0415
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0039 0.0522
Onchocerca volvulus Pyruvate kinase homolog 0.0037 0.0118 0.0164
Loa Loa (eye worm) hypothetical protein 0.0098 0.045 0.1727
Giardia lamblia Thioredoxin reductase 0.0164 0.0809 0.3831
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0039 0.0522
Loa Loa (eye worm) hypothetical protein 0.0038 0.0127 0.0487
Trypanosoma cruzi hexose transporter, putative 0.0136 0.0656 0.8746
Schistosoma mansoni cellular tumor antigen P53 0.0152 0.0744 0.1603
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0031 0.0089 0.0193
Schistosoma mansoni sugar transporter 0.0062 0.0253 0.0546
Echinococcus multilocularis chaperonin containing TCP1, subunit 2 (beta) 0.0027 0.0064 0.0115
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.0164 0.0809 0.3526
Loa Loa (eye worm) hypothetical protein 0.006 0.0243 0.0933
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0044 0.016 0.2131
Trypanosoma cruzi hexose transporter 0.0136 0.0656 0.8746
Trypanosoma brucei glucose transporter, putative 0.0136 0.0656 0.8746
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0062 0.0253 0.265
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0044 0.016 0.2131
Trichomonas vaginalis sugar transporter, putative 0.0062 0.0253 0.1104
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0098 0.0428
Brugia malayi MH2 domain containing protein 0.0018 0.0016 0.0062
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0153 0.075 1
Leishmania major glucose transporter, lmgt2 0.0136 0.0656 0.8746
Plasmodium vivax ataxin-2 like protein, putative 0.0054 0.0213 0.0192
Mycobacterium tuberculosis Conserved protein 0.0041 0.0143 0.0805
Trichomonas vaginalis sugar transporter, putative 0.0062 0.0253 0.1104
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0114 0.0537 0.0968
Giardia lamblia Hexose transporter 0.0062 0.0253 0.1128
Trichomonas vaginalis chaperonin, putative 0.0027 0.0064 0.0278
Trypanosoma cruzi pyruvate kinase 2, putative 0.0037 0.0118 0.1579
Echinococcus granulosus Threonyl tRNA synthetase C 0.0025 0.0053 0.0095
Leishmania major T-complex protein 1, beta subunit, putative 0.0027 0.0064 0.0851
Onchocerca volvulus 0.0082 0.0366 0.4057
Trypanosoma brucei glucose transporter 2A 0.0136 0.0656 0.8746
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0082 0.0366 0.1406
Mycobacterium ulcerans lipase LipD 0.0041 0.0143 0.1366
Schistosoma mansoni smad 0.0018 0.0016 0.0035
Mycobacterium tuberculosis Conserved protein 0.0041 0.0143 0.0805
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0134 0.0647 0.1165
Trypanosoma brucei glucose transporter, putative 0.0136 0.0656 0.8746
Brugia malayi jmjC domain containing protein 0.0114 0.0537 0.2064
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0131 0.0632 0.1138
Echinococcus multilocularis Smad4 0.0018 0.0016 0.0029
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0334 0.1733 0.7555
Echinococcus multilocularis short transient receptor potential channel 6 0.0143 0.0694 0.1251
Onchocerca volvulus 0.0062 0.0253 0.2286
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0334 0.1733 0.8314
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0035 0.0111 0.1478
Trichomonas vaginalis sugar transporter, putative 0.0062 0.0253 0.1104
Trypanosoma cruzi Aminoacyl-tRNA editing domain containing protein, putative 0.0022 0.0037 0.0499
Mycobacterium ulcerans esterase/lipase LipP 0.0041 0.0143 0.1366
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.0062 0.0253 0.1648
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0031 0.0089 0.0161
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0044 0.016 0.0288
Toxoplasma gondii PHD-finger domain-containing protein 0.0035 0.0108 0.0131
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0129 0.0622 0.2389
Loa Loa (eye worm) hypothetical protein 0.0136 0.0655 0.2518
Brugia malayi MH2 domain containing protein 0.0262 0.1341 0.5152
Brugia malayi Latrophilin receptor protein 2 0.0129 0.0622 0.2389
Entamoeba histolytica hypothetical protein 0.0071 0.0307 0.1317
Onchocerca volvulus 0.0062 0.0253 0.2286
Loa Loa (eye worm) hypothetical protein 0.0025 0.0053 0.0204
Brugia malayi Major Facilitator Superfamily protein 0.0062 0.0253 0.0973
Trypanosoma cruzi hexose transporter, putative 0.0074 0.0322 0.4293
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0098 0.045 0.5993
Onchocerca volvulus 0.0041 0.0143 0.0548
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0098 0.0428
Brugia malayi Calcitonin receptor-like protein seb-1 0.0409 0.2139 0.822
Echinococcus multilocularis isocitrate dehydrogenase 0.0031 0.0089 0.0161
Loa Loa (eye worm) MH2 domain-containing protein 0.0262 0.1341 0.5152
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0039 0.0522
Loa Loa (eye worm) hypothetical protein 0.004 0.0135 0.0518
Mycobacterium ulcerans prolyl-tRNA synthetase 0.0046 0.0171 0.1732
Trypanosoma brucei THT1 - hexose transporter, putative 0.0136 0.0656 0.8746
Loa Loa (eye worm) jmjC domain-containing protein 0.0072 0.0309 0.1187
Brugia malayi Sugar transporter family protein 0.0437 0.2294 0.8816
Mycobacterium ulcerans threonyl-tRNA synthetase 0.0025 0.0053 0.0202
Trichomonas vaginalis sugar transporter, putative 0.0062 0.0253 0.1104
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0098 0.0428
Plasmodium falciparum calcium-dependent protein kinase 1 0.0134 0.0647 0.0627
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0044 0.016 0.2131
Brugia malayi hypothetical protein 0.0062 0.0253 0.0973
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0134 0.0647 0.1165
Schistosoma mansoni pyruvate kinase 0.0019 0.0022 0.0046
Plasmodium falciparum phd finger protein, putative 0.0035 0.0108 0.0087
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0114 0.0537 0.0968
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0334 0.1733 0.7555
Echinococcus granulosus tumor protein p63 0.1037 0.5552 1
Echinococcus granulosus solute carrier family 22 0.0062 0.0253 0.0456
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0194 0.0974 0.3744
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0002 0.0026
Leishmania major protein kinase, putative 0.0134 0.0647 0.8622
Loa Loa (eye worm) hypothetical protein 0.0038 0.0127 0.0487
Trypanosoma cruzi hexose transporter, putative 0.0136 0.0656 0.8746
Loa Loa (eye worm) T-complex protein 1 0.0027 0.0064 0.0245
Echinococcus granulosus peregrin 0.0035 0.0108 0.0195
Schistosoma mansoni lamin 0.0082 0.0366 0.0789
Trypanosoma brucei Aminoacyl-tRNA editing domain containing protein, putative 0.0022 0.0037 0.0499
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0194 0.0974 0.21
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0044 0.016 0.2131
Entamoeba histolytica hypothetical protein 0.0071 0.0307 0.1317
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0041 0.0143 0.0549
Echinococcus multilocularis solute carrier family 22 0.0062 0.0253 0.0456
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0039 0.0522
Trichomonas vaginalis sugar transporter, putative 0.0062 0.0253 0.1104
Mycobacterium ulcerans DNA polymerase IV 0.0022 0.0039 0.0022
Echinococcus multilocularis peregrin 0.0035 0.0108 0.0195
Loa Loa (eye worm) sugar transporter 0.0062 0.0253 0.0973
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0027 0.0064 0.0138
Toxoplasma gondii glycyl-tRNA synthetase 0.0025 0.0053 0.0048
Trichomonas vaginalis penicillin-binding protein, putative 0.0041 0.0143 0.0622
Brugia malayi glycyl-tRNA synthetase 0.0025 0.0053 0.0204
Mycobacterium ulcerans sugar transporter 0.0062 0.0253 0.2798
Trypanosoma brucei unspecified product 0.0022 0.0039 0.0522
Trichomonas vaginalis sugar transporter, putative 0.0062 0.0253 0.1104
Loa Loa (eye worm) hypothetical protein 0.0171 0.0846 0.3253
Mycobacterium tuberculosis Conserved protein 0.0041 0.0143 0.0805
Trypanosoma brucei glucose transporter, putative 0.0136 0.0656 0.8746
Schistosoma mansoni hypothetical protein 0.0035 0.0108 0.0233
Echinococcus multilocularis pyruvate kinase 0.0037 0.0118 0.0213
Giardia lamblia GTOR 0.0044 0.016 0.0673
Giardia lamblia DINP protein human, muc B family 0.0022 0.0039 0.0086
Loa Loa (eye worm) hypothetical protein 0.0062 0.0253 0.0973
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0194 0.0974 0.1755
Trichomonas vaginalis esterase, putative 0.0041 0.0143 0.0622
Schistosoma mansoni terminal deoxycytidyl transferase 0.0022 0.0039 0.0084
Echinococcus granulosus dna polymerase kappa 0.0022 0.0039 0.0071
Toxoplasma gondii sugar transporter ST1 0.0062 0.0253 0.0351
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0037 0.0163
Plasmodium falciparum T-complex protein 1 subunit beta 0.0027 0.0064 0.0042
Echinococcus multilocularis pyruvate kinase 0.0037 0.0118 0.0213
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0022 0.0039 0.0071
Brugia malayi Isocitrate dehydrogenase 0.0031 0.0089 0.0343
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0108 0.0087
Onchocerca volvulus 0.0062 0.0253 0.2286
Echinococcus granulosus solute carrier family 22 0.0062 0.0253 0.0456
Leishmania major pyruvate kinase 0.0037 0.0118 0.1579
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0062 0.0253 0.1648
Mycobacterium ulcerans integral membrane transport protein 0.0062 0.0253 0.2798
Leishmania major myo-inositol/proton symporter (MIT) 0.0062 0.0253 0.3378
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0129 0.0622 0.112
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0031 0.0089 0.0161
Onchocerca volvulus 0.0062 0.0253 0.2286
Brugia malayi major facilitator superfamily protein 0.0062 0.0253 0.0973
Echinococcus multilocularis GPCR, family 2 0.0129 0.0622 0.112
Trichomonas vaginalis sugar transporter, putative 0.0136 0.0656 0.2859
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0707 0.3757 0.5653
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0134 0.0647 0.0947
Echinococcus granulosus TGF beta signal transducer SmadC 0.0018 0.0016 0.0029
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0031 0.0089 0.1191
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0131 0.0632 0.2428
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0018 0.0019 0.0256
Echinococcus multilocularis tumor protein p63 0.1037 0.5552 1
Onchocerca volvulus 0.0062 0.0253 0.2286
Mycobacterium tuberculosis Probable thioredoxin reductase TrxB2 (TRXR) (TR) 0.0164 0.0809 0.5892
Loa Loa (eye worm) hypothetical protein 0.0062 0.0253 0.0973
Echinococcus multilocularis lysyl tRNA synthetase 0.0098 0.045 0.081
Schistosoma mansoni smad1 5 8 and 0.0018 0.0016 0.0035
Leishmania major hypothetical protein, conserved 0.0022 0.0037 0.0499
Trypanosoma brucei glucose transporter 1E 0.0136 0.0656 0.8746
Loa Loa (eye worm) jmjC domain-containing protein 0.0042 0.0148 0.0567
Brugia malayi major facilitator superfamily protein 0.0062 0.0253 0.0973
Mycobacterium ulcerans glycyl-tRNA synthetase 0.0025 0.0053 0.0202
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0334 0.1733 0.7555
Trichomonas vaginalis CAMK family protein kinase 0.0134 0.0647 0.2818
Loa Loa (eye worm) hypothetical protein 0.0131 0.0632 0.2428
Trichomonas vaginalis glucose transporter, putative 0.0136 0.0656 0.2859
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0027 0.0064 0.0138
Trypanosoma cruzi hexose transporter, putative 0.0062 0.0253 0.3378
Schistosoma mansoni hypothetical protein 0.0129 0.0622 0.134
Giardia lamblia TCP-1 chaperonin subunit beta 0.0027 0.0064 0.0206
Echinococcus granulosus transient receptor potential gamma protein 0.0216 0.1091 0.1965
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0134 0.0647 0.2485
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0041 0.0143 0.0805
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0098 0.045 0.5993
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0049 0.0214
Toxoplasma gondii isocitrate dehydrogenase 0.0031 0.0089 0.0103
Wolbachia endosymbiont of Brugia malayi thioredoxin reductase 0.0164 0.0809 1
Onchocerca volvulus 0.0062 0.0253 0.2286
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0134 0.0647 0.2485
Echinococcus multilocularis PHD finger protein rhinoceros 0.0035 0.0108 0.0195
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0039 0.0522
Onchocerca volvulus 0.0101 0.0467 0.5641
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0164 0.0809 0.3526
Trypanosoma brucei unspecified product 0.0015 0.0002 0.0026
Echinococcus granulosus mothers against decapentaplegic 5 0.0018 0.0016 0.0029
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0049 0.0214
Echinococcus multilocularis jumonji domain containing protein 0.0048 0.0182 0.0328
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0031 0.0089 0.1191
Brugia malayi cytoplasmic intermediate filament protein 0.0044 0.0159 0.0609
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0044 0.016 0.0288
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0131 0.0632 0.1362
Trypanosoma brucei threonyl-tRNA synthetase, putative 0.0025 0.0053 0.0706
Schistosoma mansoni serine/threonine protein kinase 0.0134 0.0647 0.1393
Trichomonas vaginalis threonyl-tRNA synthetase, putative 0.0025 0.0053 0.0231
Schistosoma mansoni hypothetical protein 0.0071 0.0307 0.0663
Schistosoma mansoni hypothetical protein 0.0024 0.0051 0.011
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0101 0.0467 0.1793
Trypanosoma cruzi DNA polymerase eta, putative 0.0022 0.0039 0.0522
Trichomonas vaginalis sugar transporter, putative 0.0062 0.0253 0.1104
Brugia malayi Smad1 0.0018 0.0016 0.0062
Trypanosoma brucei hypothetical protein, conserved 0.0041 0.0143 0.1904
Schistosoma mansoni jumonji/arid domain-containing protein 0.0042 0.0148 0.0318
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0037 0.0163
Trypanosoma brucei glucose transporter, putative 0.0136 0.0656 0.8746
Schistosoma mansoni lysyl-tRNA synthetase 0.0098 0.045 0.0969
Loa Loa (eye worm) hypothetical protein 0.0062 0.0253 0.0973
Schistosoma mansoni survival motor neuron protein 0.0101 0.0467 0.1006
Schistosoma mansoni protein kinase 0.0134 0.0647 0.1393
Trichomonas vaginalis sugar transporter, putative 0.0062 0.0253 0.1104
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.016 0.0697
Plasmodium falciparum calcium-dependent protein kinase 4 0.0134 0.0647 0.0627
Trichomonas vaginalis sugar transporter, putative 0.0062 0.0253 0.1104
Trypanosoma brucei T-complex protein 1, beta subunit, putative 0.0027 0.0064 0.0851
Echinococcus multilocularis survival motor neuron protein 1 0.0494 0.2603 0.4688
Brugia malayi Pyruvate kinase, muscle isozyme 0.0037 0.0118 0.0455
Leishmania major lysyl-tRNA synthetase, putative 0.0098 0.045 0.5993
Schistosoma mansoni smad1 5 8 and 0.0018 0.0016 0.0035
Plasmodium vivax pyruvate kinase, putative 0.0037 0.0118 0.0097
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0039 0.0522
Trypanosoma cruzi hypothetical protein, conserved 0.0022 0.0037 0.0499
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0194 0.0974 0.1755
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0002 0.0026
Loa Loa (eye worm) MH2 domain-containing protein 0.0018 0.0016 0.0062
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0062 0.0253 0.0456
Onchocerca volvulus 0.0062 0.0253 0.2286
Brugia malayi isocitrate dehydrogenase 0.0031 0.0089 0.0343
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0437 0.2294 0.4133
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0129 0.0622 0.112
Trichomonas vaginalis sugar transporter, putative 0.0062 0.0253 0.1104
Plasmodium falciparum mitogen-activated protein kinase 2 0.0707 0.3757 0.3744
Chlamydia trachomatis lysine--tRNA ligase 0.0098 0.045 0.5244
Plasmodium falciparum ataxin-2 like protein, putative 0.0054 0.0213 0.0192
Echinococcus granulosus Sugar transporter ERD6 protein 0.0062 0.0253 0.0456
Trichomonas vaginalis D-aminoacylase, putative 0.0041 0.0143 0.0622
Plasmodium vivax CDK-related protein kinase 6, putative 0.1857 1 1
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0134 0.0647 0.1165
Trypanosoma cruzi T-complex protein 1, beta subunit, putative 0.0027 0.0064 0.0851
Trypanosoma brucei THT1 - hexose transporter, putative 0.0136 0.0656 0.8746
Trichomonas vaginalis D-aminoacylase, putative 0.0041 0.0143 0.0622
Loa Loa (eye worm) hypothetical protein 0.0062 0.0253 0.0973
Plasmodium vivax hypothetical protein, conserved 0.0041 0.0143 0.0122
Echinococcus granulosus TRP transient receptor potential channel 0.008 0.0355 0.064
Leishmania major threonyl-tRNA synthetase, putative 0.0025 0.0053 0.0706
Schistosoma mansoni intermediate filament proteins 0.0082 0.0366 0.0789
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0062 0.0253 0.2798
Onchocerca volvulus 0.0082 0.0366 0.4057
Giardia lamblia Glycyl-tRNA synthetase 0.0025 0.0053 0.0153
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0163 0.0806 0.5865
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0031 0.0089 0.1191
Trypanosoma brucei DNA polymerase IV, putative 0.0022 0.0039 0.0522
Mycobacterium leprae Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase) (ThrRS) (Threonine-tRNA ligase) 0.0025 0.0053 0.0202
Brugia malayi Sugar transporter family protein 0.0062 0.0253 0.0973
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0164 0.0809 0.3526
Echinococcus granulosus pyruvate kinase 0.0019 0.0022 0.0039
Echinococcus multilocularis synaptic vesicle 2 protein 0.0062 0.0253 0.0456
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0044 0.016 0.0592
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0031 0.0089 0.1191
Brugia malayi beta-lactamase family protein 0.0041 0.0143 0.0549
Schistosoma mansoni transient receptor potential channel 0.0143 0.0694 0.1496
Schistosoma mansoni glucose transport protein 0.0437 0.2294 0.4944
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0224 0.1138 0.4372
Trichomonas vaginalis sugar transporter, putative 0.0062 0.0253 0.1104
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0044 0.016 0.0592
Trypanosoma brucei glucose transporter, putative 0.0136 0.0656 0.8746
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0098 0.045 0.1959
Schistosoma mansoni glucose transport protein 0.0437 0.2294 0.4944
Chlamydia trachomatis thioredoxin reductase 0.0164 0.0809 1
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0031 0.0089 0.0068
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0062 0.0253 0.2798
Schistosoma mansoni glucose transport protein 0.0437 0.2294 0.4944
Loa Loa (eye worm) hypothetical protein 0.0062 0.0253 0.0973
Echinococcus granulosus transient receptor potential ion channel A 0.0209 0.1052 0.1895
Trichomonas vaginalis sugar transport protein, putative 0.0062 0.0253 0.1104
Echinococcus granulosus short transient receptor potential channel 6 0.0143 0.0694 0.1251
Giardia lamblia Fructose-bisphosphate aldolase 0.0334 0.1733 0.8328
Entamoeba histolytica protein kinase, putative 0.0134 0.0647 0.2981
Trichomonas vaginalis sugar transporter, putative 0.0062 0.0253 0.1104
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0031 0.0089 0.0068
Onchocerca volvulus Putative transporter 0.0062 0.0253 0.2286
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0063 0.0275
Onchocerca volvulus 0.0062 0.0253 0.2286
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0134 0.0647 0.1165
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0022 0.0039 0.0013
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0071 0.0307 0.0554
Treponema pallidum prolyl-tRNA synthetase 0.0046 0.0171 0.0703
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0083 0.037 0.2536
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0039 0.0522
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0063 0.0275
Mycobacterium tuberculosis Conserved hypothetical protein 0.0022 0.0039 0.0013
Brugia malayi Intermediate filament tail domain containing protein 0.0082 0.0366 0.1406
Leishmania major pyruvate kinase 0.0037 0.0118 0.1579
Trypanosoma brucei DNA polymerase IV, putative 0.0022 0.0039 0.0522
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0334 0.1733 0.7555
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.0025 0.0053 0.0706
Echinococcus granulosus geminin 0.087 0.4641 0.8359
Entamoeba histolytica glycyl-tRNA synthetase, putative 0.0025 0.0053 0.0068
Trichomonas vaginalis sugar transporter, putative 0.0062 0.0253 0.1104
Brugia malayi beta-lactamase 0.0041 0.0143 0.0549
Echinococcus multilocularis solute carrier family 22 0.0062 0.0253 0.0456
Echinococcus multilocularis lysine specific demethylase 5A 0.0042 0.0148 0.0266
Giardia lamblia PHD finger protein 15 0.0035 0.0108 0.0421
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0054 0.0212 0.0814
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0194 0.0974 0.1755
Schistosoma mansoni jumonji domain containing protein 0.009 0.041 0.0884
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0134 0.0647 0.0947
Leishmania major DNA polymerase kappa, putative 0.0022 0.0039 0.0522
Giardia lamblia Pyruvate kinase 0.0037 0.0118 0.0471
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0194 0.0974 0.3744
Chlamydia trachomatis pyruvate kinase 0.0037 0.0118 0.0866
Loa Loa (eye worm) hypothetical protein 0.0107 0.0498 0.1915
Echinococcus multilocularis transient receptor potential ion channel A 0.0209 0.1052 0.1895
Giardia lamblia Prolyl-tRNA synthetase 0.0131 0.0632 0.2969
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0098 0.045 0.534
Trypanosoma cruzi hexose transporter, putative 0.0136 0.0656 0.8746
Mycobacterium tuberculosis Probable esterase LipL 0.0041 0.0143 0.0805
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0035 0.0111 0.1478
Trypanosoma cruzi hypothetical protein, conserved 0.0022 0.0037 0.0499
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0041 0.0143 0.0549
Loa Loa (eye worm) pyruvate kinase 0.0037 0.0118 0.0455
Chlamydia trachomatis proline--tRNA ligase 0.0046 0.0171 0.1562
Plasmodium falciparum calcium-dependent protein kinase 5 0.0134 0.0647 0.0627
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0044 0.016 0.0614
Echinococcus multilocularis transient receptor potential gamma protein 0.0216 0.1091 0.1965
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0153 0.075 1
Echinococcus multilocularis beta LACTamase domain containing family member 0.0041 0.0143 0.0257
Echinococcus granulosus smad 0.0018 0.0016 0.0029
Entamoeba histolytica T-complex protein 1 beta subunit, putative 0.0027 0.0064 0.0121
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0022 0.0039 0.0084
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0039 0.0522
Trypanosoma brucei glucose transporter, putative 0.0136 0.0656 0.8746
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0049 0.0214
Brugia malayi Bromodomain containing protein 0.0035 0.0108 0.0415
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0041 0.0143 0.0308
Trichomonas vaginalis sugar transporter, putative 0.0062 0.0253 0.1104
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0131 0.0632 0.7704
Loa Loa (eye worm) hypothetical protein 0.0081 0.0358 0.1375
Echinococcus granulosus calcium activated potassium channel 0.0016 0.0004 0.0007
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0409 0.2139 0.822
Trichomonas vaginalis conserved hypothetical protein 0.0062 0.0253 0.1104
Loa Loa (eye worm) hypothetical protein 0.0022 0.0039 0.015
Brugia malayi Transient-receptor-potential like protein 0.008 0.0355 0.1365
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0334 0.1733 0.8314
Echinococcus granulosus Smad4 0.0018 0.0016 0.0029
Schistosoma mansoni hypothetical protein 0.087 0.4641 1
Toxoplasma gondii protein kinase, putative 0.1236 0.663 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0334 0.1733 0.7555
Loa Loa (eye worm) hypothetical protein 0.0041 0.0143 0.0549
Loa Loa (eye worm) hypothetical protein 0.028 0.1437 0.5521
Loa Loa (eye worm) major facilitator superfamily transporter 0.0062 0.0253 0.0973
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0129 0.0622 0.112
Brugia malayi intermediate filament protein 0.0082 0.0366 0.1406
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0134 0.0647 0.1165
Schistosoma mansoni transient receptor potential channel 0.0216 0.1091 0.2351
Echinococcus granulosus lamin dm0 0.0082 0.0366 0.0659
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0134 0.0647 0.8622
Trichomonas vaginalis sugar transporter, putative 0.0062 0.0253 0.1104
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0153 0.075 1
Loa Loa (eye worm) hypothetical protein 0.0073 0.0316 0.1215
Schistosoma mansoni hypothetical protein 0.0101 0.0467 0.1006
Mycobacterium leprae Probable pyruvate kinase PykA 0.0037 0.0118 0.105
Brugia malayi Pyruvate kinase, M2 isozyme 0.0037 0.0118 0.0455
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0027 0.0064 0.0138
Loa Loa (eye worm) latrophilin receptor protein 2 0.0129 0.0622 0.2389
Schistosoma mansoni hypothetical protein 0.0129 0.0622 0.134
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0143 0.1904
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.004 0.0135 0.0243
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0062 0.0253 0.0232
Trichomonas vaginalis sugar transporter, putative 0.0062 0.0253 0.1104
Plasmodium falciparum calcium-dependent protein kinase 3 0.0134 0.0647 0.0627
Mycobacterium ulcerans DNA polymerase IV 0.0022 0.0039 0.0022
Toxoplasma gondii isocitrate dehydrogenase 0.0031 0.0089 0.0103
Mycobacterium ulcerans hypothetical protein 0.0041 0.0143 0.1366
Echinococcus granulosus muscleblind protein 0.0171 0.0846 0.1525
Loa Loa (eye worm) sugar transporter 0.0437 0.2294 0.8816
Loa Loa (eye worm) hypothetical protein 0.0041 0.0143 0.0549
Loa Loa (eye worm) hypothetical protein 0.0054 0.0213 0.0817
Toxoplasma gondii threonyl-tRNA synthetase family protein 0.0025 0.0053 0.0048
Brugia malayi jmjC domain containing protein 0.0042 0.0148 0.0567
Plasmodium vivax proline--tRNA ligase, putative 0.0153 0.075 0.073
Echinococcus multilocularis solute carrier family 22 0.0062 0.0253 0.0456
Loa Loa (eye worm) pyruvate kinase 0.0037 0.0118 0.0455
Plasmodium falciparum calcium-dependent protein kinase 2 0.0134 0.0647 0.0627
Toxoplasma gondii pyruvate kinase PyK1 0.0037 0.0118 0.0147
Schistosoma mansoni glucose transporter 0.0062 0.0253 0.0546
Toxoplasma gondii t-complex protein beta subunit 0.0027 0.0064 0.0064
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0024 0.0051 0.0092
Loa Loa (eye worm) hypothetical protein 0.0082 0.0366 0.1406
Echinococcus granulosus pyruvate kinase 0.0019 0.0022 0.0039
Entamoeba histolytica hypothetical protein 0.0098 0.045 0.2014
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0021 0.0033 0.0441
Trichomonas vaginalis sugar transporter, putative 0.0062 0.0253 0.1104
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0063 0.0275
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.0025 0.0053 0.0706
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0044 0.016 0.0344
Giardia lamblia Sugar-proton symporter 0.0062 0.0253 0.1128
Trichomonas vaginalis DNA polymerase eta, putative 0.0022 0.0039 0.0171
Entamoeba histolytica hypothetical protein 0.0071 0.0307 0.1317
Mycobacterium ulcerans beta-lactamase 0.0041 0.0143 0.1366
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0022 0.0039 0.0171
Mycobacterium tuberculosis Probable lipase LipE 0.0041 0.0143 0.0805
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0134 0.0647 0.0627
Plasmodium falciparum lysine--tRNA ligase 0.0098 0.045 0.0429
Brugia malayi latrophilin 2 splice variant baaae 0.028 0.1437 0.5521
Brugia malayi ImpB/MucB/SamB family protein 0.0022 0.0039 0.015
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0334 0.1733 0.7555
Schistosoma mansoni lamin 0.0082 0.0366 0.0789
Echinococcus granulosus pyruvate kinase 0.0037 0.0118 0.0213
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0111 0.0482
Loa Loa (eye worm) glycyl-tRNA synthetase 0.0025 0.0053 0.0204
Loa Loa (eye worm) hypothetical protein 0.0134 0.0647 0.2485
Schistosoma mansoni transcription factor LCR-F1 0.0071 0.0307 0.0663
Loa Loa (eye worm) beta-lactamase 0.0041 0.0143 0.0549
Echinococcus multilocularis TRP (transient receptor potential) channel 0.008 0.0355 0.064
Plasmodium vivax calcium-dependent protein kinase, putative 0.0134 0.0647 0.0627
Loa Loa (eye worm) hypothetical protein 0.0062 0.0253 0.0973
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0134 0.0647 0.0627
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0098 0.045 0.534
Brugia malayi Muscleblind-like protein 0.0171 0.0846 0.3253
Brugia malayi beta-lactamase family protein 0.0041 0.0143 0.0549
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0334 0.1733 0.7555
Plasmodium vivax hexose transporter 0.0437 0.2294 0.2278
Trichomonas vaginalis sugar transporter, putative 0.0062 0.0253 0.1104
Echinococcus granulosus glycyl tRNA synthetase 0.0025 0.0053 0.0095
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0086 0.0384 0.1674
Loa Loa (eye worm) intermediate filament protein 0.0082 0.0366 0.1406
Trichomonas vaginalis sugar transporter, putative 0.0062 0.0253 0.1104
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0131 0.0632 0.1138
Echinococcus granulosus General substrate transporter 0.0376 0.1961 0.3531
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0194 0.0974 0.21
Echinococcus multilocularis short transient receptor potential channel 6 0.0143 0.0694 0.1251
Loa Loa (eye worm) hypothetical protein 0.0062 0.0253 0.0973
Trichomonas vaginalis sugar transporter, putative 0.0136 0.0656 0.2859
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0039 0.0522
Onchocerca volvulus 0.0041 0.0143 0.0548
Trichomonas vaginalis conserved hypothetical protein 0.0062 0.0253 0.1104
Onchocerca volvulus Pyruvate kinase homolog 0.0037 0.0118 0.0164
Trypanosoma brucei glucose transporter, putative 0.0136 0.0656 0.8746
Trichomonas vaginalis chaperonin-60kD, ch60, putative 0.0027 0.0064 0.0278
Loa Loa (eye worm) hypothetical protein 0.0409 0.2139 0.822
Trichomonas vaginalis sugar transporter, putative 0.0062 0.0253 0.1104
Loa Loa (eye worm) pyruvate kinase 0.0037 0.0118 0.0455
Brugia malayi MH1 domain containing protein 0.0018 0.0016 0.0062
Leishmania major glucose transporter, lmgt1 0.0136 0.0656 0.8746
Mycobacterium tuberculosis Probable hydrolase 0.0041 0.0143 0.0805
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0409 0.2139 0.822
Trichomonas vaginalis sugar transporter, putative 0.0062 0.0253 0.1104
Trichomonas vaginalis conserved hypothetical protein 0.0062 0.0253 0.1104
Trypanosoma brucei THT1 - hexose transporter, putative 0.0136 0.0656 0.8746
Trypanosoma brucei pyruvate kinase 1 0.0037 0.0118 0.1579
Trypanosoma brucei sugar transporter, putative 0.0062 0.0253 0.3378
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0164 0.0809 0.3526
Toxoplasma gondii sugar transporter ST2 0.0062 0.0253 0.0351
Brugia malayi T-complex protein 1, beta subunit 0.0027 0.0064 0.0245
Brugia malayi MH2 domain containing protein 0.0018 0.0016 0.0062
Trypanosoma brucei pyruvate kinase 1, putative 0.0037 0.0118 0.1579
Entamoeba histolytica Rad52/22 family double-strand break repair protein, putative 0.0113 0.0533 0.2425
Echinococcus multilocularis muscleblind protein 1 0.0171 0.0846 0.1525
Giardia lamblia DNA repair protein RAD52 0.0397 0.2077 1
Loa Loa (eye worm) hypothetical protein 0.0062 0.0253 0.0973
Plasmodium vivax T-complex protein 1 subunit beta, putative 0.0027 0.0064 0.0042
Toxoplasma gondii target of rapamycin (TOR), putative 0.0033 0.0098 0.0116
Loa Loa (eye worm) pyruvate kinase-PB 0.0026 0.0058 0.0224
Echinococcus multilocularis Threonyl tRNA synthetase, C 0.0025 0.0053 0.0095
Plasmodium vivax lysine--tRNA ligase, putative 0.0098 0.045 0.0429
Mycobacterium leprae conserved hypothetical protein 0.0041 0.0143 0.1366
Loa Loa (eye worm) threonyl-tRNA synthetase 0.0025 0.0053 0.0204
Mycobacterium tuberculosis Probable lipase LipD 0.0041 0.0143 0.0805
Trichomonas vaginalis conserved hypothetical protein 0.0062 0.0253 0.1104
Entamoeba histolytica protein kinase, putative 0.0134 0.0647 0.2981
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0437 0.2294 0.4133
Onchocerca volvulus 0.0062 0.0253 0.2286
Schistosoma mansoni DNA polymerase eta 0.0022 0.0039 0.0084
Plasmodium falciparum protein kinase 7 0.1236 0.663 0.6623
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.016 0.0697
Echinococcus multilocularis lamin 0.0082 0.0366 0.0659
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0022 0.0039 0.0071
Loa Loa (eye worm) hypothetical protein 0.0131 0.0632 0.2428
Trypanosoma cruzi Aminoacyl-tRNA editing domain containing protein, putative 0.0022 0.0037 0.0499
Echinococcus granulosus pyruvate kinase 0.0037 0.0118 0.0213
Entamoeba histolytica DNA repair and recombination protein RAD52, putative 0.0397 0.2077 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0098 0.0428
Echinococcus granulosus lysine specific demethylase 5A 0.0042 0.0148 0.0266
Trypanosoma brucei glycyl-tRNA synthetase, putative 0.0025 0.0053 0.0706
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0111 0.0482
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0049 0.0214
Trichomonas vaginalis penicillin-binding protein, putative 0.0041 0.0143 0.0622
Loa Loa (eye worm) Smad1 0.0018 0.0016 0.0062
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0071 0.0307 0.0554
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0134 0.0647 0.1165
Trichomonas vaginalis sugar transporter, putative 0.0062 0.0253 0.1104
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0039 0.0522
Trichomonas vaginalis glucose transporter, putative 0.0062 0.0253 0.1104
Mycobacterium ulcerans pyruvate kinase 0.0037 0.0118 0.105
Echinococcus multilocularis pyruvate kinase 0.0019 0.0022 0.0039
Plasmodium vivax glycine--tRNA ligase, putative 0.0025 0.0053 0.0032
Mycobacterium tuberculosis Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase)(ThrRS) (threonine-tRNA ligase) 0.0025 0.0053 0.0119
Leishmania major DNA polymerase eta, putative 0.0022 0.0039 0.0522
Echinococcus granulosus cytoplasmic intermediate filament protein 0.004 0.0135 0.0243
Leishmania major hypothetical protein, conserved 0.0062 0.0253 0.3378
Brugia malayi lysyl-tRNA synthetase 0.0098 0.045 0.1727
Leishmania major glucose transporter, lmgt3 0.0136 0.0656 0.8746
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0437 0.2294 0.4133
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0018 0.0016 0.0029
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0031 0.0089 0.0396
Echinococcus granulosus pyruvate kinase 0.0019 0.0022 0.0039
Brugia malayi threonyl-tRNA synthetase, cytoplasmic 0.0025 0.0053 0.0204
Echinococcus granulosus jumonji domain containing protein 0.0048 0.0182 0.0328
Trichomonas vaginalis conserved hypothetical protein 0.0136 0.0656 0.2859
Leishmania major hypothetical protein, conserved 0.0041 0.0143 0.1904
Schistosoma mansoni protein kinase 0.0134 0.0647 0.1393
Brugia malayi probable proline-trna synthetase - fission yeast, putative 0.0025 0.0053 0.0204
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0131 0.0632 0.2909
Trypanosoma cruzi target of rapamycin kinase 3 0.0035 0.0111 0.1478
Trypanosoma cruzi pyruvate kinase 2, putative 0.0037 0.0118 0.1579
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0134 0.0647 0.0947
Loa Loa (eye worm) hypothetical protein 0.0062 0.0253 0.0973
Plasmodium falciparum hexose transporter 0.0437 0.2294 0.2278
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0031 0.0089 0.0161
Brugia malayi hypothetical protein 0.0071 0.0307 0.1181
Schistosoma mansoni hypothetical protein 0.0437 0.2294 0.4944
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0194 0.0974 0.1755
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0039 0.0522
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0049 0.0214
Trichomonas vaginalis conserved hypothetical protein 0.0062 0.0253 0.1104
Echinococcus granulosus short transient receptor potential channel 6 0.0143 0.0694 0.1251
Schistosoma mansoni hypothetical protein 0.0129 0.0622 0.134
Plasmodium vivax threonine--tRNA ligase, putative 0.0025 0.0053 0.0032
Trichomonas vaginalis sugar transporter, putative 0.0062 0.0253 0.1104
Trichomonas vaginalis sugar transporter, putative 0.0062 0.0253 0.1104
Loa Loa (eye worm) hypothetical protein 0.0041 0.0143 0.0549
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0049 0.0214
Onchocerca volvulus 0.0062 0.0253 0.2286
Treponema pallidum fructose-bisphosphate aldolase 0.0334 0.1733 1
Loa Loa (eye worm) transcription factor SMAD2 0.0262 0.1341 0.5152
Loa Loa (eye worm) hypothetical protein 0.0035 0.0108 0.0415
Echinococcus multilocularis pyruvate kinase 0.0019 0.0022 0.0039
Onchocerca volvulus 0.0062 0.0253 0.2286
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.016 0.0697
Trichomonas vaginalis conserved hypothetical protein 0.0136 0.0656 0.2859
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0044 0.016 0.2131
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0002 0.0026
Loa Loa (eye worm) hypothetical protein 0.0037 0.0118 0.0455
Leishmania major hypothetical protein, conserved 0.0054 0.0213 0.2837
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0111 0.0482
Echinococcus granulosus GPCR family 2 0.0129 0.0622 0.112
Toxoplasma gondii sugar transporter ST3 0.0062 0.0253 0.0351
Loa Loa (eye worm) hypothetical protein 0.0062 0.0253 0.0973
Schistosoma mansoni transient receptor potential channel 0.0143 0.0694 0.1496
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0022 0.0039 0.0522
Treponema pallidum thioredoxin reductase (trxB) 0.0164 0.0809 0.4499
Onchocerca volvulus 0.0152 0.0744 1
Mycobacterium leprae THIOREDOXIN TRXC (TRX) (MPT46) 0.0164 0.0809 1
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0031 0.0089 0.0161
Echinococcus granulosus solute carrier family 22 0.0062 0.0253 0.0456
Echinococcus multilocularis dna polymerase kappa 0.0022 0.0039 0.0071
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0049 0.0214
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0062 0.0269
Loa Loa (eye worm) hypothetical protein 0.0041 0.0143 0.0549
Brugia malayi T-complex protein 1, beta subunit 0.0027 0.0064 0.0245
Toxoplasma gondii facilitative glucose transporter GT1 0.0437 0.2294 0.3439
Schistosoma mansoni smad1 5 8 and 0.0018 0.0016 0.0035
Trichomonas vaginalis glucose transporter, putative 0.0136 0.0656 0.2859
Loa Loa (eye worm) hypothetical protein 0.0171 0.0846 0.3253
Schistosoma mansoni jumonji/arid domain-containing protein 0.0042 0.0148 0.0318
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0083 0.037 0.4305
Trichomonas vaginalis sugar transporter, putative 0.0062 0.0253 0.1104
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0031 0.0089 0.0161
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0437 0.2294 0.4133
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0129 0.0622 0.112
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0164 0.0809 0.3526
Trypanosoma brucei unspecified product 0.0015 0.0002 0.0026
Loa Loa (eye worm) hypothetical protein 0.0062 0.0253 0.0973
Loa Loa (eye worm) hypothetical protein 0.0041 0.0143 0.0549
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0022 0.0039 0.015
Schistosoma mansoni lysyl-tRNA synthetase 0.0098 0.045 0.0969
Echinococcus multilocularis geminin 0.087 0.4641 0.8359
Plasmodium falciparum pyruvate kinase 0.0037 0.0118 0.0097
Brugia malayi Major Facilitator Superfamily protein 0.0062 0.0253 0.0973
Echinococcus multilocularis calcium activated potassium channel 0.0016 0.0004 0.0007
Trichomonas vaginalis sugar transporter, putative 0.0062 0.0253 0.1104
Trichomonas vaginalis sugar transporter, putative 0.0062 0.0253 0.1104
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0134 0.0647 0.1165
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0062 0.0269
Schistosoma mansoni hypothetical protein 0.0129 0.0622 0.134
Loa Loa (eye worm) hypothetical protein 0.0062 0.0253 0.0973
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0039 0.0522
Trichomonas vaginalis pyruvate kinase, putative 0.0037 0.0118 0.0516
Schistosoma mansoni protein kinase 0.0134 0.0647 0.1393
Trichomonas vaginalis sugar transporter, putative 0.0062 0.0253 0.1104
Onchocerca volvulus 0.0062 0.0253 0.2286
Echinococcus granulosus chaperonin containing TCP1 subunit 2 beta 0.0027 0.0064 0.0115
Echinococcus multilocularis muscleblind protein 0.0171 0.0846 0.1525
Entamoeba histolytica thioredoxin reductase, putative 0.0164 0.0809 0.3778
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0263 0.1347 1
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0031 0.0089 0.1191
Trypanosoma cruzi glucose transporter, putative 0.0062 0.0253 0.3378
Echinococcus granulosus solute carrier family 22 0.0062 0.0253 0.0456
Echinococcus multilocularis lamin dm0 0.0082 0.0366 0.0659
Entamoeba histolytica threonyl-tRNA synthetase, putative 0.0025 0.0053 0.0068
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0041 0.0143 0.0805
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0039 0.0522
Schistosoma mansoni hypothetical protein 0.028 0.1437 0.3096
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0062 0.0253 0.3378
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0143 0.1904
Trypanosoma brucei DNA polymerase eta, putative 0.0022 0.0039 0.0522
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0083 0.037 0.2536
Echinococcus granulosus lysyl tRNA synthetase 0.0098 0.045 0.081
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0437 0.2294 0.4133
Echinococcus granulosus calcium dependent protein kinase 0.0126 0.0602 0.1084
Loa Loa (eye worm) isocitrate dehydrogenase 0.0031 0.0089 0.0343
Echinococcus granulosus beta LACTamase domain containing family member 0.0041 0.0143 0.0257
Giardia lamblia Threonyl-tRNA synthetase 0.0025 0.0053 0.0153
Schistosoma mansoni sugar transporter 0.0062 0.0253 0.0546
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0041 0.0143 0.0308
Schistosoma mansoni Smad4 0.0018 0.0016 0.0035
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0153 0.075 0.1102
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0018 0.0016 0.0035
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0111 0.0482
Brugia malayi Major Facilitator Superfamily protein 0.0062 0.0253 0.0973
Echinococcus granulosus dna polymerase eta 0.0022 0.0039 0.0071
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0707 0.3757 0.3744
Echinococcus multilocularis calcium dependent protein kinase 0.0126 0.0602 0.1084
Entamoeba histolytica hypothetical protein 0.0071 0.0307 0.1317
Toxoplasma gondii YbaK/proline-tRNA ligase associated domain-containing protein 0.0022 0.0037 0.0024
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0039 0.0522

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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