Detailed information for compound 700730

Basic information

Technical information
  • TDR Targets ID: 700730
  • Name: N-(2,5-difluorophenyl)-1-[(4-fluorophenyl)met hyl]-2-oxo-1,8-naphthyridine-3-carboxamide
  • MW: 409.361 | Formula: C22H14F3N3O2
  • H donors: 1 H acceptors: 3 LogP: 3.62 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: Fc1ccc(cc1)Cn1c(=O)c(cc2c1nccc2)C(=O)Nc1cc(F)ccc1F
  • InChi: 1S/C22H14F3N3O2/c23-15-5-3-13(4-6-15)12-28-20-14(2-1-9-26-20)10-17(22(28)30)21(29)27-19-11-16(24)7-8-18(19)25/h1-11H,12H2,(H,27,29)
  • InChiKey: WDSVYIXEAHZBDC-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(2,5-difluorophenyl)-1-(4-fluorobenzyl)-2-keto-1,8-naphthyridine-3-carboxamide
  • ZINC05305034

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0371 0.1081 0.1081
Treponema pallidum exodeoxyribonuclease (exoA) 0.0038 0.0046 0.5
Schistosoma mansoni ap endonuclease 0.0038 0.0046 0.0225
Schistosoma mansoni hypothetical protein 0.0192 0.0525 0.2558
Onchocerca volvulus 0.0046 0.0072 0.0254
Schistosoma mansoni ap endonuclease 0.0038 0.0046 0.0225
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0371 0.1081 0.5265
Brugia malayi Helix-loop-helix DNA-binding domain containing protein 0.0106 0.0257 0.0901
Loa Loa (eye worm) hypothetical protein 0.0117 0.0292 0.1021
Echinococcus granulosus FTZ F1 alpha 0.003 0.0021 0.0073
Onchocerca volvulus 0.003 0.0021 0.0074
Loa Loa (eye worm) PHD-finger family protein 0.0028 0.0016 0.0055
Brugia malayi RNA recognition motif domain containing protein 0.0193 0.0529 0.1852
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0142 0.0369 0.1798
Onchocerca volvulus 0.0096 0.0227 0.0807
Echinococcus granulosus microtubule associated protein 2 0.0684 0.2053 0.7187
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0046 0.0072 0.0168
Brugia malayi Latrophilin receptor protein 2 0.0062 0.012 0.0419
Echinococcus granulosus histone lysine methyltransferase setb 0.0117 0.0292 0.1021
Leishmania major 4-coumarate:coa ligase-like protein 0.0046 0.0072 0.1939
Echinococcus granulosus intermediate filament protein 0.0053 0.0092 0.0322
Schistosoma mansoni hypothetical protein 0.0062 0.012 0.0583
Schistosoma mansoni smad1 5 8 and 0.0025 0.0005 0.0022
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0128 0.3469
Schistosoma mansoni survival motor neuron protein 0.0192 0.0525 0.2558
Onchocerca volvulus 0.0037 0.0042 0.015
Loa Loa (eye worm) jmjC domain-containing protein 0.0034 0.0034 0.0119
Echinococcus multilocularis jumonji domain containing protein 0.0039 0.005 0.005
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0062 0.012 0.012
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0077 0.0168 0.0168
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0029 0.0069
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.003 0.0021 0.0073
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0113 0.0278 0.0974
Brugia malayi Bromodomain containing protein 0.0028 0.0016 0.0055
Loa Loa (eye worm) hypothetical protein 0.003 0.0021 0.0073
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0142 0.0369 0.0868
Echinococcus multilocularis transcription factor eb 0.0106 0.0257 0.0257
Loa Loa (eye worm) hypothetical protein 0.0046 0.0072 0.0251
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0195 0.0534 0.1869
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0033 0.0031 0.0109
Loa Loa (eye worm) TAR-binding protein 0.0193 0.0529 0.1852
Brugia malayi hypothetical protein 0.0311 0.0895 0.3134
Echinococcus multilocularis peregrin 0.0028 0.0016 0.0016
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0046 0.0072 0.0168
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0037 0.0044 0.1199
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0371 0.1081 0.5265
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0117 0.0292 0.0292
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0025 0.0007 0.0025
Brugia malayi Nuclear hormone receptor family member nhr-40 0.003 0.0021 0.0073
Brugia malayi cytoplasmic intermediate filament protein 0.0028 0.0016 0.0055
Echinococcus granulosus retinoic acid receptor rxr beta a 0.003 0.0021 0.0073
Schistosoma mansoni RAR-like nuclear receptor 0.003 0.0021 0.0102
Echinococcus granulosus nuclear receptor 2DBD gamma 0.003 0.0021 0.0073
Loa Loa (eye worm) MH2 domain-containing protein 0.0362 0.1055 0.3692
Schistosoma mansoni cellular tumor antigen P53 0.0098 0.0234 0.114
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0038 0.0046 0.0046
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.003 0.0021 0.0102
Echinococcus granulosus peregrin 0.0028 0.0016 0.0055
Loa Loa (eye worm) RNA binding protein 0.0193 0.0529 0.1852
Trichomonas vaginalis D-aminoacylase, putative 0.0142 0.0369 0.1311
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0037 0.0043 0.0462
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0035 0.0035 0.0083
Echinococcus granulosus ecdysone induced protein 78C 0.003 0.0021 0.0073
Loa Loa (eye worm) hypothetical protein 0.0133 0.0342 0.1198
Trichomonas vaginalis set domain proteins, putative 0.0929 0.2815 1
Echinococcus multilocularis inositol monophosphatase 1 0.0036 0.0041 0.0041
Onchocerca volvulus Huntingtin homolog 0.012 0.0302 0.1073
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0036 0.0041 0.0097
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.003 0.0021 0.0102
Schistosoma mansoni intermediate filament proteins 0.0053 0.0092 0.0448
Mycobacterium tuberculosis Transcriptional regulatory repressor protein (TetR-family) EthR 0.1391 0.4253 1
Brugia malayi Steroid receptor seven-up type 2 0.003 0.0021 0.0073
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.003 0.0021 0.0073
Loa Loa (eye worm) MH1 domain-containing protein 0.0025 0.0005 0.0016
Echinococcus multilocularis survival motor neuron protein 1 0.0942 0.2857 0.2857
Onchocerca volvulus Protein ultraspiracle homolog 0.003 0.0021 0.0074
Brugia malayi Glycosyl hydrolases family 31 protein 0.0037 0.0043 0.0149
Schistosoma mansoni lamin 0.0053 0.0092 0.0448
Plasmodium vivax acyl-CoA synthetase, putative 0.0035 0.0035 0.0955
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0041 0.1116
Brugia malayi Nuclear hormone receptor family member nhr-14 0.003 0.0021 0.0073
Schistosoma mansoni alpha glucosidase 0.0037 0.0043 0.0208
Loa Loa (eye worm) hypothetical protein 0.0098 0.0234 0.0819
Trypanosoma cruzi PAB1-binding protein , putative 0.0074 0.0158 0.429
Loa Loa (eye worm) hypothetical protein 0.0035 0.0035 0.0123
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0046 0.0072 0.0168
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0041 0.1116
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0037 0.0044 0.0044
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0041 0.0146
Brugia malayi hypothetical protein 0.032 0.0923 0.3232
Brugia malayi steroid hormone receptor 0.003 0.0021 0.0073
Echinococcus multilocularis ubiquitin specific protease 41 0.0037 0.0044 0.0044
Echinococcus multilocularis neutral alpha glucosidase AB 0.0037 0.0043 0.0043
Echinococcus granulosus tumor protein p63 0.0673 0.202 0.707
Onchocerca volvulus 0.0142 0.0369 0.1311
Loa Loa (eye worm) hypothetical protein 0.0046 0.0072 0.0251
Brugia malayi Nuclear hormone receptor family member nhr-1 0.003 0.0021 0.0073
Schistosoma mansoni tar DNA-binding protein 0.0193 0.0529 0.2577
Plasmodium falciparum acyl-CoA synthetase 0.0035 0.0035 0.2226
Echinococcus multilocularis PHD finger protein rhinoceros 0.0028 0.0016 0.0016
Echinococcus granulosus GPCR family 2 0.0062 0.012 0.0419
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0117 0.0292 0.7902
Trypanosoma cruzi PAB1-binding protein , putative 0.0074 0.0158 0.429
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0371 0.1081 0.3784
Giardia lamblia PHD finger protein 15 0.0028 0.0016 0.3365
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0193 0.0529 0.1852
Echinococcus granulosus geminin 0.0492 0.1458 0.5102
Onchocerca volvulus 0.0142 0.0369 0.1311
Loa Loa (eye worm) hypothetical protein 0.0142 0.0369 0.1292
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0046 0.0164
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0062 0.012 0.0419
Loa Loa (eye worm) hypothetical protein 0.0048 0.0078 0.0274
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0043 0.0152
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0062 0.012 0.0419
Loa Loa (eye worm) hypothetical protein 0.003 0.0021 0.0073
Brugia malayi Pre-SET motif family protein 0.0117 0.0292 0.1021
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0037 0.0044 0.0216
Brugia malayi Pre-SET motif family protein 0.0816 0.2465 0.8628
Brugia malayi Nuclear hormone receptor family member nhr-3 0.003 0.0021 0.0073
Loa Loa (eye worm) intermediate filament protein 0.0053 0.0092 0.0322
Echinococcus granulosus Smad4 0.0025 0.0005 0.0016
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0077 0.0168 0.059
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0077 0.0168 0.0396
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0033 0.0031 0.0031
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0371 0.1081 0.3784
Loa Loa (eye worm) hypothetical protein 0.003 0.0021 0.0073
Loa Loa (eye worm) hypothetical protein 0.003 0.0021 0.0073
Mycobacterium ulcerans esterase/lipase LipP 0.0142 0.0369 0.0868
Loa Loa (eye worm) inositol-1 0.0036 0.0041 0.0144
Brugia malayi Nuclear hormone receptor-like 1 0.003 0.0021 0.0073
Mycobacterium ulcerans TetR family transcriptional regulator 0.1391 0.4253 1
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0046 0.0072 0.0168
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.003 0.0021 0.0073
Leishmania major 4-coumarate:coa ligase-like protein 0.0046 0.0072 0.1939
Loa Loa (eye worm) hypothetical protein 0.0142 0.0369 0.1292
Trypanosoma brucei PAB1-binding protein , putative 0.0074 0.0158 0.429
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0036 0.0041 0.0446
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0128 0.3469
Brugia malayi MH1 domain containing protein 0.0025 0.0005 0.0016
Onchocerca volvulus 0.0142 0.0369 0.1311
Loa Loa (eye worm) hypothetical protein 0.003 0.0021 0.0073
Echinococcus granulosus inositol monophosphatase 1 0.0036 0.0041 0.0144
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0092 0.0215 0.0215
Loa Loa (eye worm) hypothetical protein 0.003 0.0021 0.0073
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0044 0.1199
Trypanosoma brucei hypothetical protein, conserved 0.0142 0.0369 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0128 0.3469
Schistosoma mansoni jumonji/arid domain-containing protein 0.0034 0.0034 0.0166
Schistosoma mansoni steroid hormone receptor ad4bp 0.003 0.0021 0.0102
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0371 0.1081 0.3784
Onchocerca volvulus 0.0098 0.0234 0.0831
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0038 0.0046 0.0109
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.003 0.0021 0.0073
Brugia malayi Nuclear hormone receptor family member nhr-19 0.003 0.0021 0.0073
Schistosoma mansoni gabp alpha 0.0074 0.0158 0.0769
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0077 0.0168 0.059
Echinococcus multilocularis thyroid hormone receptor alpha 0.003 0.0021 0.0021
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.003 0.0021 0.0021
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0037 0.0044 0.9561
Loa Loa (eye worm) hypothetical protein 0.0035 0.0035 0.0123
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.003 0.0021 0.0021
Onchocerca volvulus Alhambra homolog 0.0028 0.0016 0.0055
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0077 0.0168 0.0396
Mycobacterium tuberculosis Conserved protein 0.0142 0.0369 0.0868
Schistosoma mansoni tar DNA-binding protein 0.0193 0.0529 0.2577
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0117 0.0292 0.0292
Schistosoma mansoni thyroid hormone receptor 0.003 0.0021 0.0102
Schistosoma mansoni tar DNA-binding protein 0.0193 0.0529 0.2577
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0044 0.0157
Loa Loa (eye worm) hypothetical protein 0.0025 0.0007 0.0025
Echinococcus granulosus beta LACTamase domain containing family member 0.0142 0.0369 0.1292
Mycobacterium tuberculosis Conserved protein 0.0142 0.0369 0.0868
Entamoeba histolytica hypothetical protein 0.032 0.0923 1
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0044 0.1199
Echinococcus multilocularis musashi 0.0053 0.0092 0.0092
Loa Loa (eye worm) hypothetical protein 0.0037 0.0044 0.0155
Trypanosoma cruzi hypothetical protein, conserved 0.0142 0.0369 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0128 0.3469
Schistosoma mansoni jumonji/arid domain-containing protein 0.0034 0.0034 0.0166
Brugia malayi Nuclear hormone receptor family member nhr-41 0.003 0.0021 0.0073
Trichomonas vaginalis sucrase-isomaltase, putative 0.0037 0.0043 0.0152
Brugia malayi photoreceptor-specific nuclear receptor 0.003 0.0021 0.0073
Toxoplasma gondii PHD-finger domain-containing protein 0.0028 0.0016 0.0422
Loa Loa (eye worm) hypothetical protein 0.0142 0.0369 0.1292
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0037 0.0043 0.0152
Mycobacterium ulcerans acyl-CoA synthetase 0.0046 0.0072 0.0168
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0037 0.0044 0.0155
Loa Loa (eye worm) hypothetical protein 0.0195 0.0534 0.1869
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0046 0.0072 0.0168
Mycobacterium tuberculosis Probable lipase LipD 0.0142 0.0369 0.0868
Loa Loa (eye worm) helix-loop-helix DNA-binding domain-containing protein 0.0106 0.0256 0.0896
Brugia malayi Nuclear hormone receptor family member nhr-19 0.003 0.0021 0.0073
Toxoplasma gondii LsmAD domain-containing protein 0.0074 0.0158 0.429
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0038 0.0046 0.0162
Echinococcus granulosus TGF beta signal transducer SmadC 0.0025 0.0005 0.0016
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0041 0.0146
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0907 0.2747 0.646
Loa Loa (eye worm) transcription factor SMAD2 0.0362 0.1055 0.3692
Brugia malayi Calcitonin receptor-like protein seb-1 0.0195 0.0534 0.1869
Trichomonas vaginalis esterase, putative 0.0142 0.0369 0.1311
Echinococcus multilocularis ecdysone induced protein 78C 0.003 0.0021 0.0021
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0046 0.0164
Loa Loa (eye worm) hypothetical protein 0.0035 0.0035 0.0123
Schistosoma mansoni alpha-glucosidase 0.0143 0.0373 0.1818
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0166 0.0445 0.1559
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.032 0.0923 0.3232
Echinococcus multilocularis lysosomal alpha glucosidase 0.0166 0.0445 0.0445
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0142 0.0369 0.1798
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0037 0.0044 0.0155
Echinococcus granulosus lamin dm0 0.0053 0.0092 0.0322
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0142 0.0369 0.1292
Mycobacterium tuberculosis Conserved protein 0.0142 0.0369 0.0868
Brugia malayi latrophilin 2 splice variant baaae 0.0133 0.0342 0.1198
Schistosoma mansoni hypothetical protein 0.0492 0.1458 0.71
Leishmania major hypothetical protein, conserved 0.0142 0.0369 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0046 0.0072 0.1939
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0043 0.0152
Schistosoma mansoni hypothetical protein 0.0133 0.0342 0.1666
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0037 0.0043 0.1156
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.003 0.0021 0.0073
Loa Loa (eye worm) hypothetical protein 0.0046 0.0072 0.0251
Echinococcus granulosus nuclear receptor 2DBD gamma 0.003 0.0021 0.0073
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0041 0.1116
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0074 0.0158 0.0553
Loa Loa (eye worm) hypothetical protein 0.003 0.0021 0.0073
Mycobacterium tuberculosis Probable esterase LipL 0.0142 0.0369 0.0868
Brugia malayi Nuclear hormone receptor family member nhr-25 0.003 0.0021 0.0073
Echinococcus multilocularis Smad4 0.0025 0.0005 0.0005
Brugia malayi beta-lactamase 0.0142 0.0369 0.1292
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0037 0.0044 0.0479
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.003 0.0021 0.0073
Brugia malayi AMP-binding enzyme family protein 0.0046 0.0072 0.0251
Mycobacterium ulcerans acyl-CoA synthetase 0.0046 0.0072 0.0168
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0077 0.0168 0.082
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0128 0.3469
Trypanosoma cruzi cruzipain precursor, putative 0.0064 0.0128 0.3469
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0028 0.0016 0.0055
Schistosoma mansoni jumonji domain containing protein 0.0073 0.0156 0.076
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0092 0.0215 0.0753
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0037 0.0043 0.0149
Brugia malayi hypothetical protein 0.0074 0.0158 0.0554
Leishmania major alpha glucosidase II subunit, putative 0.0037 0.0043 0.1156
Loa Loa (eye worm) hypothetical protein 0.0053 0.0092 0.0322
Schistosoma mansoni hypothetical protein 0.0033 0.0031 0.0152
Brugia malayi intermediate filament protein 0.0053 0.0092 0.0322
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0046 0.0072 0.0168
Brugia malayi Glycosyl hydrolases family 31 protein 0.0166 0.0445 0.1559
Entamoeba histolytica hypothetical protein 0.032 0.0923 1
Onchocerca volvulus 0.0192 0.0525 0.1866
Brugia malayi MH2 domain containing protein 0.0025 0.0005 0.0016
Onchocerca volvulus 0.0117 0.0292 0.1036
Echinococcus multilocularis geminin 0.0492 0.1458 0.1458
Echinococcus granulosus mothers against decapentaplegic 5 0.0025 0.0005 0.0016
Brugia malayi jmjC domain containing protein 0.0034 0.0034 0.0119
Brugia malayi RNA binding protein 0.0193 0.0529 0.1852
Echinococcus granulosus GA binding protein alpha chain 0.0074 0.0158 0.0553
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.003 0.0021 0.0073
Entamoeba histolytica acyl-CoA synthetase, putative 0.0046 0.0072 0.0776
Trypanosoma cruzi cysteine peptidase, putative 0.0064 0.0128 0.3469
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0062 0.012 0.0419
Echinococcus multilocularis lamin 0.0053 0.0092 0.0092
Mycobacterium ulcerans hypothetical protein 0.0046 0.0072 0.0168
Schistosoma mansoni hypothetical protein 0.0062 0.012 0.0583
Brugia malayi Inositol-1 0.0036 0.0041 0.0144
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0037 0.0044 0.0044
Mycobacterium leprae Probable lipase LipE 0.0142 0.0369 0.0868
Loa Loa (eye worm) hypothetical protein 0.0106 0.0256 0.0896
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0035 0.0035 0.5
Loa Loa (eye worm) hypothetical protein 0.0028 0.0016 0.0055
Echinococcus multilocularis GA binding protein alpha chain 0.0074 0.0158 0.0158
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0077 0.0168 0.4562
Brugia malayi hypothetical protein 0.0048 0.0077 0.0268
Schistosoma mansoni retinoid-x-receptor (RXR) 0.003 0.0021 0.0102
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0053 0.0092 0.0322
Brugia malayi Smad1 0.0025 0.0005 0.0016
Schistosoma mansoni smad 0.0025 0.0005 0.0022
Brugia malayi MH1 domain containing protein 0.0025 0.0005 0.0016
Trichomonas vaginalis D-aminoacylase, putative 0.0142 0.0369 0.1311
Plasmodium vivax ataxin-2 like protein, putative 0.0074 0.0158 0.429
Echinococcus multilocularis lamin dm0 0.0053 0.0092 0.0092
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0043 0.1156
Loa Loa (eye worm) latrophilin receptor protein 2 0.0062 0.012 0.0419
Schistosoma mansoni transcription factor LCR-F1 0.032 0.0923 0.4497
Brugia malayi Ets-domain containing protein 0.0074 0.0158 0.0553
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0038 0.0046 1
Trichomonas vaginalis maltase-glucoamylase, putative 0.0037 0.0043 0.0152
Plasmodium falciparum ataxin-2 like protein, putative 0.0074 0.0158 1
Mycobacterium tuberculosis Probable hydrolase 0.0142 0.0369 0.0868
Trypanosoma cruzi cysteine peptidase, putative 0.0064 0.0128 0.3469
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.003 0.0021 0.0073
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0036 0.0041 0.1116
Schistosoma mansoni hypothetical protein 0.0492 0.1458 0.71
Mycobacterium ulcerans hypothetical protein 0.0142 0.0369 0.0868
Toxoplasma gondii PHD-finger domain-containing protein 0.0028 0.0016 0.0422
Schistosoma mansoni hypothetical protein 0.032 0.0923 0.4497
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0117 0.0292 0.1421
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0029 0.0069
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0033 0.0029 0.0069
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.003 0.0021 0.0073
Loa Loa (eye worm) hypothetical protein 0.0142 0.0369 0.1292
Loa Loa (eye worm) hypothetical protein 0.0942 0.2857 1
Echinococcus multilocularis microtubule associated protein 2 0.0684 0.2053 0.2053
Mycobacterium ulcerans lipase LipD 0.0142 0.0369 0.0868
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0128 0.3469
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.003 0.0021 0.0073
Brugia malayi beta-lactamase family protein 0.0142 0.0369 0.1292
Plasmodium falciparum phd finger protein, putative 0.0028 0.0016 0.0983
Leishmania major hypothetical protein, conserved 0.0074 0.0158 0.429
Brugia malayi ecdysteroid receptor 0.003 0.0021 0.0073
Plasmodium falciparum ataxin-2 like protein, putative 0.0074 0.0158 1
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.003 0.0021 0.0074
Schistosoma mansoni alpha-glucosidase 0.0143 0.0373 0.1818
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0142 0.0369 0.0868
Loa Loa (eye worm) hypothetical protein 0.0025 0.0004 0.0014
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0046 0.0072 0.0168
Loa Loa (eye worm) hypothetical protein 0.012 0.0302 0.1057
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0371 0.1081 0.5265
Echinococcus multilocularis beta LACTamase domain containing family member 0.0142 0.0369 0.0369
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0038 0.0046 0.1254
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0046 0.0072 0.0168
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0128 0.3469
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0043 0.0152
Loa Loa (eye worm) hypothetical protein 0.0052 0.0089 0.0312
Brugia malayi nuclear receptor NHR-88 0.003 0.0021 0.0073
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0117 0.0292 0.1421
Brugia malayi Nuclear hormone receptor family member nhr-25 0.003 0.0021 0.0073
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0117 0.0292 0.1421
Echinococcus multilocularis smad 0.0025 0.0005 0.0005
Entamoeba histolytica acyl-CoA synthetase, putative 0.0046 0.0072 0.0776
Onchocerca volvulus 0.0053 0.0092 0.0327
Echinococcus granulosus lysosomal alpha glucosidase 0.0166 0.0445 0.1559
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0025 0.0005 0.0005
Leishmania major cathepsin L-like protease 0.0064 0.0128 0.3469
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.003 0.0021 0.0073
Leishmania major cathepsin L-like protease 0.0064 0.0128 0.3469
Loa Loa (eye worm) hypothetical protein 0.0142 0.0369 0.1292
Schistosoma mansoni thyroid hormone receptor 0.003 0.0021 0.0102
Loa Loa (eye worm) hypothetical protein 0.012 0.0302 0.1057
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.003 0.0021 0.0021
Brugia malayi Fli-1 protein 0.0225 0.0626 0.2192
Loa Loa (eye worm) hypothetical protein 0.0062 0.012 0.0419
Brugia malayi jmjC domain containing protein 0.0092 0.0215 0.0753
Mycobacterium leprae Probable transcriptional regulatory repressor protein (TetR-family) EthR 0.1391 0.4253 1
Schistosoma mansoni hypothetical protein 0.0062 0.012 0.0583
Loa Loa (eye worm) hypothetical protein 0.0311 0.0895 0.3134
Echinococcus granulosus lysine specific demethylase 5A 0.0034 0.0034 0.0119
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.003 0.0021 0.0021
Loa Loa (eye worm) hypothetical protein 0.003 0.0021 0.0073
Brugia malayi AMP-binding enzyme family protein 0.0046 0.0072 0.0251
Echinococcus granulosus jumonji domain containing protein 0.0039 0.005 0.0175
Entamoeba histolytica hypothetical protein 0.032 0.0923 1
Echinococcus granulosus survival motor neuron protein 1 0.0942 0.2857 1
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0059 0.0111 0.2999
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0036 0.0041 0.8902
Trichomonas vaginalis penicillin-binding protein, putative 0.0142 0.0369 0.1311
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0371 0.1081 0.3784
Plasmodium vivax SET domain protein, putative 0.0117 0.0292 0.7902
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0043 0.1156
Trypanosoma brucei glucosidase, putative 0.0037 0.0043 0.1156
Trichomonas vaginalis inositol monophosphatase, putative 0.0036 0.0041 0.0146
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0062 0.012 0.012
Loa Loa (eye worm) MH2 domain-containing protein 0.0025 0.0005 0.0016
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0028 0.0016 0.0076
Onchocerca volvulus Huntingtin homolog 0.012 0.0302 0.1073
Echinococcus granulosus smad 0.0025 0.0005 0.0016
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0128 0.3469
Mycobacterium tuberculosis Probable lipase LipE 0.0142 0.0369 0.0868
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0038 0.0046 0.0109
Brugia malayi exodeoxyribonuclease III family protein 0.0038 0.0046 0.0162
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0128 0.3469
Trypanosoma cruzi major cysteine proteinase, putative 0.0051 0.0085 0.2309
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0037 0.0044 0.0157
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0038 0.0046 1
Loa Loa (eye worm) fli-1 protein 0.0225 0.0626 0.2192
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0038 0.0046 0.0162
Brugia malayi nuclear hormone receptor 0.003 0.0021 0.0073
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.032 0.0923 0.0923
Schistosoma mansoni lamin 0.0053 0.0092 0.0448
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.003 0.0021 0.0021
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0037 0.0044 0.0216
Toxoplasma gondii exonuclease III APE 0.0038 0.0046 0.1254
Loa Loa (eye worm) hypothetical protein 0.0035 0.0035 0.0123
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0041 0.1116
Brugia malayi MH2 domain containing protein 0.0362 0.1055 0.3692
Mycobacterium ulcerans transcriptional regulator 0.1391 0.4253 1
Echinococcus multilocularis GPCR, family 2 0.0062 0.012 0.012
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0046 0.1254
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0038 0.0046 0.1254
Schistosoma mansoni tar DNA-binding protein 0.0193 0.0529 0.2577
Brugia malayi Nuclear hormone receptor family member nhr-31 0.003 0.0021 0.0073
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0142 0.0369 0.1292
Schistosoma mansoni coup transcription factor 0.003 0.0021 0.0102
Loa Loa (eye worm) hypothetical protein 0.0025 0.0004 0.0014
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0025 0.0007 0.0007
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0035 0.0035 0.0083
Loa Loa (eye worm) jmjC domain-containing protein 0.0058 0.0109 0.0382
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0128 0.3469
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0043 0.0152
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.003 0.0021 0.0073
Brugia malayi Intermediate filament tail domain containing protein 0.0053 0.0092 0.0322
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0142 0.0369 0.0868
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0038 0.0046 0.0501
Brugia malayi MH2 domain containing protein 0.0025 0.0005 0.0016
Onchocerca volvulus Bile acid receptor homolog 0.003 0.0021 0.0074
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.003 0.0021 0.0021
Loa Loa (eye worm) hypothetical protein 0.0063 0.0125 0.0436
Mycobacterium leprae conserved hypothetical protein 0.0142 0.0369 0.0868
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0033 0.0029 0.0069
Echinococcus granulosus tar DNA binding protein 0.0193 0.0529 0.1852
Brugia malayi PHD-finger family protein 0.0028 0.0016 0.0055
Echinococcus multilocularis FTZ F1 alpha 0.003 0.0021 0.0021
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0037 0.0044 0.0157
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.003 0.0021 0.0102
Plasmodium vivax hypothetical protein, conserved 0.0028 0.0016 0.0422
Schistosoma mansoni hypothetical protein 0.0028 0.0016 0.0076
Echinococcus granulosus transcription factor eb 0.0106 0.0257 0.0901
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0142 0.0369 0.0868
Loa Loa (eye worm) hypothetical protein 0.0142 0.0369 0.1292
Loa Loa (eye worm) beta-lactamase 0.0142 0.0369 0.1292
Brugia malayi beta-lactamase family protein 0.0142 0.0369 0.1292
Schistosoma mansoni hypothetical protein 0.0062 0.012 0.0583
Schistosoma mansoni smad1 5 8 and 0.0025 0.0005 0.0022
Brugia malayi TAR-binding protein 0.0193 0.0529 0.1852
Echinococcus multilocularis mothers against decapentaplegic 5 0.0025 0.0005 0.0005
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0371 0.1081 0.1081
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.003 0.0021 0.0073
Onchocerca volvulus 0.0929 0.2815 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0043 0.0152
Entamoeba histolytica hypothetical protein 0.032 0.0923 1
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0037 0.0043 0.0152
Schistosoma mansoni retinoic acid receptor RXR 0.003 0.0021 0.0102
Brugia malayi hypothetical protein 0.0942 0.2857 1
Schistosoma mansoni inositol monophosphatase 0.0036 0.0041 0.0201
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0037 0.0044 0.0155
Schistosoma mansoni nuclear hormone receptor 0.003 0.0021 0.0102
Plasmodium vivax hypothetical protein, conserved 0.0142 0.0369 1
Echinococcus granulosus lamin 0.0053 0.0092 0.0322
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.003 0.0021 0.0102
Loa Loa (eye worm) steroid hormone receptor 0.003 0.0021 0.0073
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0037 0.0043 0.0462
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0038 0.0046 0.1254
Loa Loa (eye worm) hypothetical protein 0.0074 0.0158 0.0554
Brugia malayi Ets-domain containing protein 0.0074 0.0158 0.0553
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0054 0.0096 0.0337
Loa Loa (eye worm) hypothetical protein 0.0035 0.0035 0.0123
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0816 0.2465 0.8628
Onchocerca volvulus 0.0053 0.0092 0.0327
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0046 0.2922
Mycobacterium ulcerans acyl-CoA synthetase 0.0046 0.0072 0.0168
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0192 0.0525 0.1839
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0038 0.0046 0.1254
Echinococcus multilocularis lysosomal alpha glucosidase 0.0166 0.0445 0.0445
Loa Loa (eye worm) Smad1 0.0025 0.0005 0.0016
Leishmania major cathepsin L-like protease 0.0064 0.0128 0.3469
Schistosoma mansoni Tr4/Tr2 (homologue) 0.003 0.0021 0.0102
Trypanosoma cruzi cysteine peptidase, putative 0.0064 0.0128 0.3469
Schistosoma mansoni ets-related 0.0225 0.0626 0.305
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0029 0.0069
Mycobacterium ulcerans AcrR family transcriptional regulator 0.1391 0.4253 1
Brugia malayi hypothetical protein 0.012 0.0302 0.1057
Mycobacterium ulcerans beta-lactamase 0.0142 0.0369 0.0868
Brugia malayi Nuclear hormone receptor family member nhr-49 0.003 0.0021 0.0073
Toxoplasma gondii ABC1 family protein 0.0142 0.0369 1
Echinococcus granulosus ubiquitin specific protease 41 0.0037 0.0044 0.0155
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0077 0.0168 0.0396
Echinococcus granulosus neutral alpha glucosidase AB 0.0037 0.0043 0.0149
Schistosoma mansoni tar DNA-binding protein 0.0193 0.0529 0.2577
Schistosoma mansoni Smad4 0.0025 0.0005 0.0022
Schistosoma mansoni inositol monophosphatase 0.0036 0.0041 0.0201
Echinococcus multilocularis lysine specific demethylase 5A 0.0034 0.0034 0.0034
Trichomonas vaginalis penicillin-binding protein, putative 0.0142 0.0369 0.1311
Trypanosoma cruzi hypothetical protein, conserved 0.0142 0.0369 1
Echinococcus multilocularis tumor protein p63 0.0673 0.202 0.202
Brugia malayi AMP-binding enzyme family protein 0.0046 0.0072 0.0251
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0029 0.0069
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0128 0.3469
Schistosoma mansoni smad1 5 8 and 0.0025 0.0005 0.0022
Echinococcus multilocularis tar DNA binding protein 0.0193 0.0529 0.0529
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0195 0.0534 0.1869
Schistosoma mansoni microtubule-associated protein tau 0.0684 0.2053 1
Echinococcus granulosus PHD finger protein rhinoceros 0.0028 0.0016 0.0055
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0025 0.0005 0.0022
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0044 0.1199
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0117 0.0292 0.1421
Trichomonas vaginalis D-aminoacylase, putative 0.0142 0.0369 0.1311
Onchocerca volvulus 0.0311 0.0895 0.318
Entamoeba histolytica acyl-coA synthetase, putative 0.0046 0.0072 0.0776

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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