TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 457.503 | Formula: C21H23N5O5S
H donors: 2 H acceptors: 5 LogP: 0.32 Rotable bonds: 9
Rule of 5 violations (Lipinski): 1
SMILES: COCc1cnc2c(c1SCC(=O)Nc1ccc(cc1)NC(=O)C)c(=O)n(c(=O)n2C)C
InChi: 1S/C21H23N5O5S/c1-12(27)23-14-5-7-15(8-6-14)24-16(28)11-32-18-13(10-31-4)9-22-19-17(18)20(29)26(3)21(30)25(19)2/h5-9H,10-11H2,1-4H3,(H,23,27)(H,24,28)
InChiKey: GUDVWEYJDGFCFA-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	alpha tubulin	0.0377	0.4813	0.745
Echinococcus granulosus	tubulin alpha chain	0.0377	0.4813	0.4813
Trichomonas vaginalis	tubulin, putative	0.05	0.646	1
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0377	0.4813	0.745
Brugia malayi	alpha-tubulin	0.0377	0.4813	0.4813
Loa Loa (eye worm)	T-complex protein 1	0.0025	0.0106	0.0106
Trichomonas vaginalis	tubulin beta chain, putative	0.0377	0.4813	0.745
Loa Loa (eye worm)	carboxylesterase	0.0058	0.0543	0.0543
Trichomonas vaginalis	tubulin beta chain, putative	0.0377	0.4813	0.745
Giardia lamblia	Epsilon tubulin	0.0155	0.1841	0.285
Schistosoma mansoni	eyes absent homolog	0.0178	0.2157	0.3338
Leishmania major	beta tubulin	0.05	0.646	1
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0061	0.0587	0.0587
Trichomonas vaginalis	tubulin gamma chain, putative	0.0129	0.1497	0.2317
Trypanosoma brucei	mitogen activated protein kinase 4, putative	0.0049	0.043	0.0666
Loa Loa (eye worm)	tyrosyl-DNA phosphodiesterase	0.0065	0.0645	0.0645
Leishmania major	alpha tubulin	0.0377	0.4813	0.745
Giardia lamblia	Delta tubulin	0.0129	0.1497	0.2317
Loa Loa (eye worm)	tubulin gamma chain	0.0307	0.3884	0.3884
Echinococcus multilocularis	acetylcholinesterase	0.0058	0.0543	0.0543
Toxoplasma gondii	aldehyde dehydrogenase	0.0061	0.0587	0.0909
Schistosoma mansoni	chaperonin containing t-complex protein 1 beta subunit tcpb	0.0025	0.0106	0.0164
Plasmodium falciparum	tubulin beta chain	0.05	0.646	1
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0129	0.1497	0.2317
Giardia lamblia	Gamma tubulin	0.0307	0.3884	0.6012
Loa Loa (eye worm)	alpha-tubulin	0.0377	0.4813	0.4813
Schistosoma mansoni	tubulin subunit alpha	0.0377	0.4813	0.745
Brugia malayi	beta-tubulin, identical	0.05	0.646	0.646
Echinococcus granulosus	tubulin alpha chain	0.0377	0.4813	0.4813
Plasmodium vivax	tubulin epsilon chain, putative	0.0307	0.3878	0.6004
Echinococcus granulosus	Tubulin beta 2C chain	0.05	0.646	0.646
Echinococcus multilocularis	Tubulin beta 2C chain	0.05	0.646	0.646
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0152	0.1809	0.28
Trichomonas vaginalis	conserved hypothetical protein	0.0129	0.1497	0.2317
Trichomonas vaginalis	inositol monophosphatase, putative	0.0038	0.0282	0.0437
Echinococcus granulosus	tubulin gamma 1 chain	0.0307	0.3884	0.3884
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0377	0.4813	0.4813
Loa Loa (eye worm)	inositol-1	0.0038	0.0282	0.0282
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0059	0.0563	0.0872
Plasmodium falciparum	ataxin-2 like protein, putative	0.0026	0.0115	0.0178
Brugia malayi	RNA recognition motif domain containing protein	0.0127	0.1473	0.1473
Trypanosoma brucei	T-complex protein 1, beta subunit, putative	0.0025	0.0106	0.0164
Echinococcus granulosus	Tubulin beta 2C chain	0.05	0.646	0.646
Treponema pallidum	cell division protein FtsZ	0.0129	0.1497	1
Echinococcus multilocularis	peroxisome assembly protein 26	0.0377	0.4813	0.4813
Schistosoma mansoni	tubulin subunit gamma	0.0307	0.3884	0.6012
Trypanosoma brucei	epsilon tubulin	0.0307	0.3878	0.6004
Trypanosoma brucei	alpha tubulin	0.0377	0.4813	0.745
Echinococcus granulosus	muscleblind protein	0.0764	1	1
Trypanosoma brucei	alpha tubulin, putative	0.0152	0.1809	0.28
Trichomonas vaginalis	tubulin beta chain, putative	0.05	0.646	1
Schistosoma mansoni	inositol monophosphatase	0.0038	0.0282	0.0437
Toxoplasma gondii	inositol(myo)-1(or 4)-monophosphatase 2, putative	0.0038	0.0282	0.0437
Trichomonas vaginalis	set domain proteins, putative	0.047	0.6058	0.9378
Schistosoma mansoni	tar DNA-binding protein	0.0127	0.1473	0.228
Schistosoma mansoni	tar DNA-binding protein	0.0127	0.1473	0.228
Trypanosoma brucei	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0065	0.0645	0.0999
Loa Loa (eye worm)	tubulin beta-2A chain	0.05	0.646	0.646
Brugia malayi	RNA binding protein	0.0127	0.1473	0.1473
Echinococcus granulosus	beta tubulin	0.05	0.646	0.646
Trypanosoma cruzi	tubulin gamma chain	0.0307	0.3884	0.6012
Giardia lamblia	Beta tubulin	0.05	0.646	1
Loa Loa (eye worm)	tubulin beta chain	0.05	0.646	0.646
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0224	0.2775	0.4296
Schistosoma mansoni	tubulin subunit beta	0.05	0.646	1
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0059	0.0563	0.0872
Leishmania major	alpha tubulin	0.0377	0.4813	0.745
Echinococcus multilocularis	tubulin alpha	0.0281	0.3534	0.3534
Leishmania major	beta tubulin	0.05	0.646	1
Trypanosoma cruzi	zeta tubulin, putative	0.0398	0.5104	0.7901
Schistosoma mansoni	aldehyde dehydrogenase	0.0061	0.0587	0.0909
Toxoplasma gondii	LsmAD domain-containing protein	0.0026	0.0115	0.0178
Echinococcus granulosus	tyrosyl DNA phosphodiesterase 1	0.0065	0.0645	0.0645
Trypanosoma brucei	beta tubulin	0.0281	0.3534	0.5471
Plasmodium vivax	delta tubulin, putative	0.0129	0.1497	0.2317
Echinococcus multilocularis	Tubulin beta 2C chain	0.05	0.646	0.646
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0044	0.0364	0.0564
Plasmodium vivax	tubulin gamma chain, putative	0.0307	0.3884	0.6012
Leishmania major	beta tubulin	0.05	0.646	1
Trypanosoma brucei	inositol-1(or 4)-monophosphatase 1, putative	0.0038	0.0282	0.0437
Echinococcus granulosus	tubulin epsilon chain	0.0307	0.3878	0.3878
Trypanosoma brucei	epsilon tubulin	0.0281	0.3534	0.5471
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0059	0.0563	0.0872
Schistosoma mansoni	tubulin subunit beta	0.05	0.646	1
Schistosoma mansoni	chaperonin containing t-complex protein 1 beta subunit tcpb	0.0025	0.0106	0.0164
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0248	0.3087	0.4779
Trichomonas vaginalis	CMGC family protein kinase	0.0049	0.043	0.0666
Trypanosoma cruzi	PAB1-binding protein , putative	0.0026	0.0115	0.0178
Leishmania major	alpha tubulin	0.0377	0.4813	0.745
Leishmania major	T-complex protein 1, beta subunit, putative	0.0025	0.0106	0.0164
Brugia malayi	Carboxylesterase family protein	0.0058	0.0543	0.0543
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0061	0.0587	0.0909
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0044	0.0364	0.0364
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.005	0.0434	0.0434
Trichomonas vaginalis	tubulin alpha chain, putative	0.05	0.646	1
Echinococcus multilocularis	Tubulin beta 2C chain	0.05	0.646	0.646
Trichomonas vaginalis	tubulin gamma chain, putative	0.05	0.646	1
Echinococcus granulosus	Tubulin beta 2C chain	0.05	0.646	0.646
Trichomonas vaginalis	tubulin, putative	0.0155	0.1846	0.2858
Onchocerca volvulus		0.0045	0.0375	0.0619
Loa Loa (eye worm)	tubulin alpha 2	0.0096	0.105	0.105
Brugia malayi	Tubulin alpha chain	0.0377	0.4813	0.4813
Loa Loa (eye worm)	BEN-1 protein	0.05	0.646	0.646
Loa Loa (eye worm)	acetylcholinesterase 1	0.0058	0.0543	0.0543
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0563	0.0563
Toxoplasma gondii	t-complex protein beta subunit	0.0025	0.0106	0.0164
Trichomonas vaginalis	tubulin beta chain, putative	0.0377	0.4813	0.745
Leishmania major	alpha tubulin	0.0377	0.4813	0.745
Mycobacterium leprae	possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ).	0.0034	0.0229	0.1527
Echinococcus granulosus	tubulin alpha 3 chain	0.0377	0.4813	0.4813
Leishmania major	hypothetical protein, conserved	0.0026	0.0115	0.0178
Loa Loa (eye worm)	TAR-binding protein	0.0127	0.1473	0.1473
Leishmania major	zeta tubulin, putative	0.0398	0.5104	0.7901
Echinococcus granulosus	tubulin alpha 1C chain	0.0377	0.4813	0.4813
Echinococcus granulosus	survival motor neuron protein 1	0.0221	0.273	0.273
Plasmodium falciparum	alpha tubulin 2	0.0377	0.4813	0.745
Echinococcus granulosus	tubulin beta 4A class IVa	0.05	0.646	0.646
Echinococcus multilocularis	muscleblind protein 1	0.0764	1	1
Leishmania major	alpha tubulin	0.0377	0.4813	0.745
Leishmania major	beta tubulin	0.05	0.646	1
Brugia malayi	Tubulin gamma chain	0.0307	0.3884	0.3884
Echinococcus granulosus	mitogen activated protein kinase 3	0.0049	0.043	0.043
Entamoeba histolytica	tubulin gamma chain	0.0307	0.3884	0.6012
Trypanosoma cruzi	epsilon tubulin, putative	0.0307	0.3878	0.6004
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0059	0.0563	0.0563
Plasmodium falciparum	ataxin-2 like protein, putative	0.0026	0.0115	0.0178
Trypanosoma cruzi	mitogen activated protein kinase 4, putative	0.0049	0.043	0.0666
Echinococcus multilocularis	muscleblind protein	0.0764	1	1
Echinococcus multilocularis	tubulin alpha chain	0.0377	0.4813	0.4813
Trypanosoma cruzi	mitogen activated protein kinase 2, putative	0.0049	0.043	0.0666
Echinococcus granulosus	tubulin beta 1 chain	0.05	0.646	0.646
Entamoeba histolytica	tyrosyl-DNA phosphodiesterase, putative	0.0065	0.0645	0.0999
Schistosoma mansoni	tubulin subunit epsilon	0.0307	0.3878	0.6004
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0061	0.0587	0.3925
Leishmania major	beta tubulin	0.05	0.646	1
Leishmania major	gamma-tubulin	0.0307	0.3884	0.6012
Trypanosoma cruzi	tubulin delta chain	0.029	0.3654	0.5657
Echinococcus granulosus	Tubulin alpha 1 chain	0.0377	0.4813	0.4813
Schistosoma mansoni	hypothetical protein	0.0045	0.0375	0.058
Entamoeba histolytica	T-complex protein 1 beta subunit, putative	0.0025	0.0106	0.0164
Schistosoma mansoni	tubulin subunit delta	0.0129	0.1497	0.2317
Echinococcus granulosus	acetylcholinesterase	0.0058	0.0543	0.0543
Trypanosoma brucei	alpha tubulin	0.0377	0.4813	0.745
Trypanosoma brucei	protein kinase, putative	0.0049	0.043	0.0666
Echinococcus granulosus	tubulin alpha	0.0281	0.3534	0.3534
Onchocerca volvulus		0.0152	0.1809	0.2986
Leishmania major	beta tubulin	0.05	0.646	1
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0049	0.043	0.0666
Trypanosoma brucei	alpha tubulin	0.0377	0.4813	0.745
Brugia malayi	Tubulin beta chain	0.0129	0.1497	0.1497
Entamoeba histolytica	myo-inositol monophosphatase, putative	0.0038	0.0282	0.0437
Plasmodium vivax	ataxin-2 like protein, putative	0.0026	0.0115	0.0178
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0044	0.0364	0.0364
Echinococcus multilocularis	inositol monophosphatase 1	0.0038	0.0282	0.0282
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0065	0.0645	0.0999
Plasmodium falciparum	tubulin delta chain, putative	0.0129	0.1497	0.2317
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0061	0.0587	0.3925
Schistosoma mansoni	tubulin subunit alpha	0.0377	0.4813	0.745
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0044	0.0364	0.0364
Trypanosoma brucei	epsilon tubulin	0.0307	0.3878	0.6004
Echinococcus multilocularis	tubulin alpha 3 chain	0.0377	0.4813	0.4813
Leishmania major	tyrosyl-DNA phosphodiesterase 1	0.0065	0.0645	0.0999
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0413	0.5295	0.5295
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0038	0.0282	0.0437
Mycobacterium tuberculosis	Inositol-1-monophosphatase SuhB	0.0034	0.0229	0.1527
Trichomonas vaginalis	tubulin gamma chain, putative	0.0307	0.3884	0.6012
Plasmodium falciparum	alpha tubulin 1	0.0377	0.4813	0.745
Loa Loa (eye worm)	tubulin alpha 2	0.0248	0.3087	0.3087
Toxoplasma gondii	beta-tubulin, putative	0.05	0.646	1
Schistosoma mansoni	tubulin subunit beta	0.05	0.646	1
Loa Loa (eye worm)	alpha-tubulin isotype 2	0.0248	0.3087	0.3087
Trichomonas vaginalis	tubulin beta chain, putative	0.0377	0.4813	0.745
Trichomonas vaginalis	CMGC family protein kinase	0.0049	0.043	0.0666
Schistosoma mansoni	tubulin subunit beta	0.05	0.646	1
Echinococcus multilocularis	mitogen activated protein kinase 3	0.0049	0.043	0.043
Echinococcus granulosus	tubulin alpha chain	0.0377	0.4813	0.4813
Toxoplasma gondii	beta tubulin	0.05	0.646	1
Loa Loa (eye worm)	tubulin alpha-3 chain	0.0224	0.2775	0.2775
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0061	0.0587	0.3925
Echinococcus granulosus	transcription factor Dp 1	0.0038	0.0277	0.0277
Echinococcus granulosus	tubulin alpha chain	0.0377	0.4813	0.4813
Brugia malayi	Calcitonin receptor-like protein seb-1	0.005	0.0434	0.0434
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0044	0.0364	0.0564
Schistosoma mansoni	alpha tubulin	0.0377	0.4813	0.745
Schistosoma mansoni	tar DNA-binding protein	0.0127	0.1473	0.228
Trypanosoma cruzi	beta tubulin, putative	0.05	0.646	1
Trichomonas vaginalis	tubulin epsilon chain, putative	0.05	0.646	1
Brugia malayi	Tubulin alpha-2 chain	0.0377	0.4813	0.4813
Mycobacterium leprae	cell division protein FtsZ	0.0129	0.1497	1
Onchocerca volvulus		0.0059	0.0563	0.093
Echinococcus multilocularis	beta tubulin	0.05	0.646	0.646
Trichomonas vaginalis	chaperonin-60kD, ch60, putative	0.0025	0.0106	0.0164
Chlamydia trachomatis	metal transport ATPase	0.0017	0	0.5
Echinococcus granulosus	peroxisome assembly protein 26	0.0377	0.4813	0.4813
Entamoeba histolytica	tubulin alpha chain, putative	0.0377	0.4813	0.745
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0543	0.0543
Toxoplasma gondii	CMGC kinase, MAPK family (ERK) MAPK-1	0.0049	0.043	0.0666
Brugia malayi	hypothetical protein	0.0178	0.2157	0.2157
Loa Loa (eye worm)	hypothetical protein	0.0248	0.3087	0.3087
Leishmania major	beta tubulin	0.05	0.646	1
Loa Loa (eye worm)	hypothetical protein	0.0221	0.273	0.273
Mycobacterium tuberculosis	Cell division protein FtsZ	0.0129	0.1497	1
Trichomonas vaginalis	CMGC family protein kinase	0.0049	0.043	0.0666
Giardia lamblia	Kinase, CMGC MAPK	0.0049	0.043	0.0666
Leishmania major	beta tubulin	0.05	0.646	1
Toxoplasma gondii	tubulin/FtsZ family, GTPase domain-containing protein	0.0281	0.3534	0.5471
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0045	0.0375	0.0375
Trichomonas vaginalis	tubulin, putative	0.0152	0.1809	0.28
Loa Loa (eye worm)	beta-tubulin	0.05	0.646	0.646
Brugia malayi	Tubulin beta chain	0.0152	0.1809	0.1809
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0061	0.0587	0.0587
Trypanosoma cruzi	epsilon tubulin, putative	0.0307	0.3878	0.6004
Loa Loa (eye worm)	hypothetical protein	0.0178	0.2157	0.2157
Trypanosoma brucei	zeta tubulin, putative	0.0398	0.5104	0.7901
Brugia malayi	latrophilin 2 splice variant baaae	0.0034	0.0224	0.0224
Trypanosoma brucei	beta tubulin	0.05	0.646	1
Trichomonas vaginalis	tubulin alpha chain, putative	0.0152	0.1809	0.28
Echinococcus granulosus	carboxylesterase 5A	0.0058	0.0543	0.0543
Echinococcus granulosus	tubulin alpha 3 chain	0.0377	0.4813	0.4813
Schistosoma mansoni	tyrosyl-DNA phosphodiesterase	0.0065	0.0645	0.0999
Trypanosoma cruzi	tubulin delta chain	0.029	0.3654	0.5657
Loa Loa (eye worm)	tubulin alpha 2	0.0248	0.3087	0.3087
Leishmania major	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440	0.0049	0.043	0.0666
Loa Loa (eye worm)	hypothetical protein	0.0764	1	1
Brugia malayi	Cell division protein ftsZ	0.0129	0.1497	0.1497
Brugia malayi	T-complex protein 1, beta subunit	0.0025	0.0106	0.0106
Leishmania major	beta tubulin	0.05	0.646	1
Leishmania major	alpha tubulin	0.0377	0.4813	0.745
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0127	0.1473	0.1473
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0038	0.0282	0.0437
Echinococcus granulosus	tubulin alpha 1C chain	0.0377	0.4813	0.4813
Trypanosoma cruzi	T-complex protein 1, beta subunit, putative	0.0025	0.0106	0.0164
Plasmodium falciparum	tubulin epsilon chain, putative	0.0307	0.3878	0.6004
Echinococcus granulosus	tar DNA binding protein	0.0127	0.1473	0.1473
Leishmania major	beta tubulin	0.05	0.646	1
Echinococcus multilocularis	tar DNA binding protein	0.0127	0.1473	0.1473
Echinococcus granulosus	Tubulin alpha 1 chain	0.0377	0.4813	0.4813
Trichomonas vaginalis	tubulin alpha chain, putative	0.0281	0.3534	0.5471
Echinococcus granulosus	chaperonin containing TCP1 subunit 2 beta	0.0025	0.0106	0.0106
Trichomonas vaginalis	tubulin beta chain, putative	0.0377	0.4813	0.745
Echinococcus granulosus	tubulin subunit beta	0.05	0.646	0.646
Toxoplasma gondii	tubulin/FtsZ family, GTPase domain-containing protein	0.0155	0.1841	0.285
Trichomonas vaginalis	tubulin alpha chain, putative	0.0152	0.1809	0.28
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0057	0.0534	0.0534
Echinococcus multilocularis	tubulin alpha 1C chain	0.0377	0.4813	0.4813
Toxoplasma gondii	tubulin/FtsZ family, GTPase domain-containing protein	0.029	0.3654	0.5657
Toxoplasma gondii	alpha tubulin TUBA1	0.0377	0.4813	0.745
Loa Loa (eye worm)	hypothetical protein	0.005	0.0434	0.0434
Echinococcus multilocularis	carboxylesterase 5A	0.0058	0.0543	0.0543
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0377	0.4813	0.4813
Leishmania major	alpha tubulin	0.0377	0.4813	0.745
Echinococcus multilocularis	Tubulin beta 2C chain	0.05	0.646	0.646
Leishmania major	beta tubulin	0.05	0.646	1
Echinococcus multilocularis	tubulin alpha chain	0.0377	0.4813	0.4813
Trichomonas vaginalis	tubulin, putative	0.0152	0.1809	0.28
Echinococcus multilocularis	tubulin alpha chain	0.0377	0.4813	0.4813
Echinococcus multilocularis	tubulin alpha chain	0.0377	0.4813	0.4813
Loa Loa (eye worm)	tubulin beta-1 chain	0.05	0.646	0.646
Trypanosoma brucei	beta tubulin	0.05	0.646	1
Mycobacterium ulcerans	cell division protein FtsZ	0.0129	0.1497	1
Schistosoma mansoni	hypothetical protein	0.0034	0.0224	0.0348
Plasmodium vivax	T-complex protein 1 subunit beta, putative	0.0025	0.0106	0.0164
Trichomonas vaginalis	tubulin alpha chain, putative	0.0152	0.1809	0.28
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.005	0.0434	0.0434
Echinococcus granulosus	alpha tubulin	0.0377	0.4813	0.4813
Echinococcus multilocularis	beta tubulin	0.05	0.646	0.646
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0543	0.0543
Schistosoma mansoni	tar DNA-binding protein	0.0127	0.1473	0.228
Toxoplasma gondii	tubulin, putative	0.0026	0.0115	0.0179
Plasmodium falciparum	T-complex protein 1 subunit beta	0.0025	0.0106	0.0164
Echinococcus multilocularis	tubulin subunit beta	0.05	0.646	0.646
Brugia malayi	T-complex protein 1, beta subunit	0.0025	0.0106	0.0106
Brugia malayi	hypothetical protein	0.0221	0.273	0.273
Loa Loa (eye worm)	hypothetical protein	0.0764	1	1
Schistosoma mansoni	tar DNA-binding protein	0.0127	0.1473	0.228
Leishmania major	mitogen activated protein kinase, putative,map kinase, putative	0.0049	0.043	0.0666
Schistosoma mansoni	tubulin subunit beta	0.05	0.646	1
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0059	0.0563	0.0563
Echinococcus multilocularis	tubulin epsilon chain	0.0307	0.3878	0.3878
Trypanosoma brucei	tubulin delta chain	0.029	0.3654	0.5657
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0377	0.4813	0.745
Leishmania major	beta tubulin	0.05	0.646	1
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0058	0.0543	0.084
Echinococcus multilocularis	hypothetical protein	0.0377	0.4813	0.4813
Entamoeba histolytica	tubulin family protein	0.05	0.646	1
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0038	0.0282	0.0437
Trypanosoma brucei	beta tubulin	0.05	0.646	1
Schistosoma mansoni	tubulin subunit beta	0.05	0.646	1
Entamoeba histolytica	tubulin alpha-1 chain	0.0377	0.4813	0.745
Brugia malayi	Inositol-1	0.0038	0.0282	0.0282
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0061	0.0587	0.3925
Echinococcus multilocularis	mitogen activated protein kinase	0.0049	0.043	0.043
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0224	0.0224
Leishmania major	delta tubulin, putative	0.029	0.3654	0.5657
Giardia lamblia	Beta tubulin	0.05	0.646	1
Trichomonas vaginalis	tubulin beta-1 chain, putative	0.0129	0.1497	0.2317
Leishmania major	alpha tubulin	0.0377	0.4813	0.745
Schistosoma mansoni	tubulin subunit alpha	0.0377	0.4813	0.745
Loa Loa (eye worm)	BEN-1 protein	0.05	0.646	0.646
Loa Loa (eye worm)	tubulin beta chain	0.0129	0.1497	0.1497
Onchocerca volvulus		0.047	0.6058	1
Plasmodium vivax	tubulin alpha chain, putative	0.0377	0.4813	0.745
Plasmodium vivax	tubulin alpha chain, putative	0.0377	0.4813	0.745
Schistosoma mansoni	survival motor neuron protein	0.0045	0.0375	0.058
Brugia malayi	hypothetical protein	0.0026	0.0115	0.0115
Plasmodium vivax	tubulin beta chain, putative	0.05	0.646	1
Trichomonas vaginalis	conserved hypothetical protein	0.0129	0.1497	0.2317
Mycobacterium ulcerans	extragenic suppressor protein SuhB	0.0038	0.0282	0.1885
Schistosoma mansoni	serine/threonine protein kinase	0.0049	0.043	0.0666
Echinococcus granulosus	tubulin alpha chain	0.0377	0.4813	0.4813
Echinococcus granulosus	Tubulin beta 2C chain	0.05	0.646	0.646
Leishmania major	epsilon tubulin, putative	0.0307	0.3878	0.6004
Echinococcus multilocularis	transcription factor Dp 1	0.0038	0.0277	0.0277
Brugia malayi	Carboxylesterase family protein	0.0058	0.0543	0.0543
Echinococcus multilocularis	tubulin alpha 3 chain	0.0377	0.4813	0.4813
Loa Loa (eye worm)	tubulin alpha chain	0.0377	0.4813	0.4813
Trichomonas vaginalis	tubulin beta chain, putative	0.0377	0.4813	0.745
Trichomonas vaginalis	tubulin beta chain, putative	0.0152	0.1809	0.28
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0115	0.0115
Echinococcus granulosus	acetylcholinesterase	0.0058	0.0543	0.0543
Brugia malayi	Tubulin beta-1 chain	0.05	0.646	0.646
Leishmania major	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0038	0.0282	0.0437
Giardia lamblia	Beta tubulin	0.05	0.646	1
Leishmania major	alpha tubulin	0.0377	0.4813	0.745
Trichomonas vaginalis	tubulin gamma chain, putative	0.0307	0.3878	0.6004
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0044	0.0364	0.0364
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0377	0.4813	0.745
Schistosoma mansoni	tubulin subunit beta	0.0129	0.1497	0.2317
Leishmania major	alpha tubulin	0.0377	0.4813	0.745
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0059	0.0563	0.0872
Trypanosoma brucei	beta tubulin	0.05	0.646	1
Echinococcus multilocularis	tubulin beta 1 chain	0.05	0.646	0.646
Echinococcus multilocularis	chaperonin containing TCP1, subunit 2 (beta)	0.0025	0.0106	0.0106
Brugia malayi	Tubulin alpha chain	0.0129	0.1497	0.1497
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0049	0.043	0.0666
Wolbachia endosymbiont of Brugia malayi	cell division protein FtsZ	0.0129	0.1497	1
Loa Loa (eye worm)	alpha-tubulin	0.0377	0.4813	0.4813
Echinococcus multilocularis	tubulin alpha 1C chain	0.0377	0.4813	0.4813
Entamoeba histolytica	tubulin family protein	0.05	0.646	1
Brugia malayi	Pre-SET motif family protein	0.0413	0.5295	0.5295
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0377	0.4813	0.4813
Leishmania major	beta tubulin	0.05	0.646	1
Trypanosoma cruzi	zeta tubulin, putative	0.0398	0.5104	0.7901
Plasmodium vivax	SET domain protein, putative	0.0059	0.0563	0.0872
Echinococcus granulosus	histone lysine methyltransferase setb	0.0059	0.0563	0.0563
Brugia malayi	tubulin alpha chain - mouse	0.0377	0.4813	0.4813
Echinococcus granulosus	tubulin delta chain	0.0129	0.1497	0.1497
Leishmania major	beta tubulin	0.05	0.646	1
Echinococcus granulosus	beta tubulin	0.05	0.646	0.646
Loa Loa (eye worm)	hypothetical protein	0.0377	0.4813	0.4813
Schistosoma mansoni	aldehyde dehydrogenase	0.0061	0.0587	0.0909
Loa Loa (eye worm)	tubulin alpha-2 chain	0.0377	0.4813	0.4813
Echinococcus multilocularis	tyrosyl DNA phosphodiesterase 1	0.0065	0.0645	0.0645
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0044	0.0364	0.0364
Echinococcus granulosus	Tubulin alpha 1 chain	0.0377	0.4813	0.4813
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0059	0.0563	0.0872
Loa Loa (eye worm)	hypothetical protein	0.0178	0.2157	0.2157
Schistosoma mansoni	alpha tubulin	0.0377	0.4813	0.745
Schistosoma mansoni	chaperonin containing t-complex protein 1 beta subunit tcpb	0.0025	0.0106	0.0164
Trypanosoma cruzi	PAB1-binding protein , putative	0.0026	0.0115	0.0178
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0038	0.0282	0.0437
Brugia malayi	Cytochrome P450 family protein	0.0026	0.0125	0.0125
Brugia malayi	MAP kinase sur-1	0.0049	0.043	0.043
Brugia malayi	Tyrosyl-DNA phosphodiesterase family protein	0.0065	0.0645	0.0645
Echinococcus multilocularis	acetylcholinesterase	0.0058	0.0543	0.0543
Toxoplasma gondii	beta-1 tubulin, putative	0.05	0.646	1
Loa Loa (eye worm)	tubulin alpha chain	0.0377	0.4813	0.4813
Leishmania major	alpha tubulin	0.0377	0.4813	0.745
Echinococcus multilocularis	tubulin gamma 1 chain	0.0307	0.3884	0.3884
Loa Loa (eye worm)	tubulin beta-4 chain	0.05	0.646	0.646
Leishmania major	beta tubulin	0.05	0.646	1
Giardia lamblia	Alpha-tubulin	0.0377	0.4813	0.745
Trypanosoma brucei	zeta tubulin	0.0398	0.5104	0.7901
Trypanosoma brucei	PAB1-binding protein , putative	0.0026	0.0115	0.0178
Trichomonas vaginalis	chaperonin, putative	0.0025	0.0106	0.0164
Echinococcus multilocularis	Tubulin beta 2C chain	0.05	0.646	0.646
Echinococcus multilocularis	tubulin, beta 4A class IVa	0.05	0.646	0.646
Giardia lamblia	Alpha-tubulin	0.0377	0.4813	0.745
Echinococcus granulosus	mitogen activated protein kinase	0.0049	0.043	0.043
Brugia malayi	Pre-SET motif family protein	0.0059	0.0563	0.0563
Leishmania major	beta tubulin	0.05	0.646	1
Plasmodium falciparum	tubulin gamma chain	0.0307	0.3884	0.6012
Echinococcus multilocularis	tubulin subunit TubB	0.0377	0.4813	0.4813
Brugia malayi	tubulin alpha-2 chain	0.0377	0.4813	0.4813
Loa Loa (eye worm)	hypothetical protein	0.0224	0.2775	0.2775
Loa Loa (eye worm)	RNA binding protein	0.0127	0.1473	0.1473
Brugia malayi	TAR-binding protein	0.0127	0.1473	0.1473
Echinococcus multilocularis	survival motor neuron protein 1	0.0221	0.273	0.273
Trypanosoma brucei	tubulin gamma chain	0.0307	0.3884	0.6012
Giardia lamblia	TCP-1 chaperonin subunit beta	0.0025	0.0106	0.0164
Echinococcus multilocularis	tubulin delta chain	0.0129	0.1497	0.1497
Schistosoma mansoni	tubulin subunit alpha	0.0129	0.1497	0.2317
Trichomonas vaginalis	tubulin epsilon chain, putative	0.05	0.646	1
Trypanosoma brucei	alpha tubulin	0.0377	0.4813	0.745
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0044	0.0364	0.0364
Leishmania major	beta tubulin	0.05	0.646	1
Trichomonas vaginalis	CMGC family protein kinase	0.0049	0.043	0.0666
Toxoplasma gondii	alpha-tubulin I, putative	0.0377	0.4813	0.745
Echinococcus granulosus	inositol monophosphatase 1	0.0038	0.0282	0.0282
Echinococcus granulosus	Tubulin beta 2C chain	0.05	0.646	0.646
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0044	0.0364	0.0564
Leishmania major	beta tubulin	0.05	0.646	1
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0065	0.0645	0.0999
Echinococcus multilocularis	tubulin alpha chain	0.0377	0.4813	0.4813
Trypanosoma cruzi	alpha tubulin, putative	0.0377	0.4813	0.745
Schistosoma mansoni	inositol monophosphatase	0.0038	0.0282	0.0437
Loa Loa (eye worm)	CMGC/MAPK/ERK1 protein kinase	0.0049	0.043	0.043
Loa Loa (eye worm)	cytochrome P450 family protein	0.0026	0.0125	0.0125
Brugia malayi	Tubulin alpha-2 chain	0.0377	0.4813	0.4813
Echinococcus granulosus	tubulin subunit TubB	0.0377	0.4813	0.4813
Leishmania major	alpha tubulin	0.0377	0.4813	0.745

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Search by Saint Jude

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 702446