Detailed information for compound 70292

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 514.469 | Formula: C20H31N6O8P
  • H donors: 8 H acceptors: 7 LogP: -5.23 Rotable bonds: 13
    Rule of 5 violations (Lipinski): 3
  • SMILES: NC(=O)CC(C(=O)N)NC(=O)C1(CCCCC1)NC(=O)C(Cc1ccc(c(c1)N)OP(=O)(O)O)N
  • InChi: 1S/C20H31N6O8P/c21-12-8-11(4-5-15(12)34-35(31,32)33)9-13(22)18(29)26-20(6-2-1-3-7-20)19(30)25-14(17(24)28)10-16(23)27/h4-5,8,13-14H,1-3,6-7,9-10,21-22H2,(H2,23,27)(H2,24,28)(H,25,30)(H,26,29)(H2,31,32,33)
  • InChiKey: YJYFCZXVXPEVDA-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium ulcerans inosine 5'-monophosphate dehydrogenase 0.1103 1 1
Mycobacterium leprae PROBABLE INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE GUAB1(IMP DEHYDROGENASE) (IMPDH) (IMPD) 0.0524 0.4689 0.4643
Echinococcus multilocularis lysine specific demethylase 5A 0.0068 0.0507 0.0507
Trichomonas vaginalis cyclin A, putative 0.0069 0.0513 0.1854
Echinococcus granulosus JmjC domain containing protein 4 0.0018 0.005 0.005
Trypanosoma cruzi chloride channel protein, putative 0.0066 0.0485 0.0437
Brugia malayi Sex muscle abnormal protein 5 0.0173 0.1471 0.144
Brugia malayi jmjC domain containing protein 0.0018 0.005 0.0014
Brugia malayi inosine-5'-monophosphate dehydrogenase 0.0459 0.4088 0.4066
Schistosoma mansoni hypothetical protein 0.0018 0.0051 0.0051
Echinococcus granulosus ecdysone induced protein 78C 0.0036 0.0209 0.0209
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0029 0.015 0.0114
Brugia malayi Protein kinase domain containing protein 0.0024 0.0104 0.0068
Brugia malayi steroid hormone receptor 0.0036 0.0209 0.0174
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0036 0.0209 0.0209
Brugia malayi STAT protein, DNA binding domain containing protein 0.0023 0.0092 0.0056
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.0065 0.0479 0.3184
Loa Loa (eye worm) SH2 domain-containing protein 0.0023 0.0092 0.0056
Loa Loa (eye worm) hypothetical protein 0.0017 0.0037 0.0001
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0071 0.0532 0.0532
Echinococcus multilocularis cyclin dependent kinase 5 0.005 0.0341 0.0341
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0058 0.0412 0.0377
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0036 0.0209 0.0174
Brugia malayi jmjC domain containing protein 0.0018 0.005 0.0014
Leishmania major methionine aminopeptidase 2, putative 0.0177 0.1505 0.1462
Onchocerca volvulus 0.0024 0.0104 0.0167
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0023 0.0092 0.0092
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0159 0.1345 0.1345
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0341 0.1109
Echinococcus granulosus 5' AMP activated protein kinase subunit gamma 0.0066 0.0485 0.0485
Trypanosoma brucei mitotic cyclin 6 0.0069 0.0513 0.0465
Loa Loa (eye worm) hypothetical protein 0.0023 0.0092 0.0056
Plasmodium falciparum cyclin 0.004 0.0254 0.0218
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0036 0.0209 0.0209
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0036 0.0209 0.0174
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0056 0.0394 0.036
Loa Loa (eye worm) steroid hormone receptor 0.0036 0.0209 0.0174
Entamoeba histolytica cyclin, putative 0.0069 0.0513 0.3407
Schistosoma mansoni protein kinase subunit gamma 0.0066 0.0485 0.0485
Loa Loa (eye worm) hypothetical protein 0.0025 0.0114 0.0079
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0177 0.1505 0.6155
Loa Loa (eye worm) SH2 domain-containing protein 0.0023 0.0092 0.0056
Mycobacterium ulcerans cytoplasmic peptidase PepQ 0.0022 0.0085 0.0034
Trypanosoma cruzi CYC2-like cyclin, putative 0.0069 0.0513 0.0465
Mycobacterium tuberculosis Conserved hypothetical membrane protein 0.0066 0.0485 0.0403
Toxoplasma gondii proliferation-associated protein 2G4, putative 0.0022 0.0085 0.0035
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.005 0.0341 0.0292
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0034 0.02 0.02
Echinococcus granulosus SH2 domain containing adapter protein F 0.0023 0.0092 0.0092
Loa Loa (eye worm) DR-78 0.0017 0.0037 0.0001
Plasmodium vivax inosine-5'-monophosphate dehydrogenase, putative 0.1038 0.9399 1
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0071 0.0532 0.0532
Echinococcus granulosus H:Cl exchange transporter 4 0.0066 0.0485 0.0485
Trypanosoma brucei Metallopeptidase family M24, putative 0.0022 0.0085 0.0035
Trichomonas vaginalis cyclin B, putative 0.004 0.0254 0.0732
Echinococcus multilocularis SH2 motif 0.0023 0.0092 0.0092
Echinococcus granulosus suppressor of cytokine signaling 7 0.0023 0.0092 0.0092
Schistosoma mansoni hypothetical protein 0.0018 0.0051 0.0051
Mycobacterium ulcerans dipeptidase 0.0022 0.0085 0.0034
Trypanosoma cruzi Metallopeptidase family M24, putative 0.0022 0.0085 0.0035
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0068 0.0507 0.0507
Brugia malayi Latrophilin receptor protein 2 0.0018 0.0051 0.0015
Loa Loa (eye worm) chloride channel 3 0.0066 0.0485 0.045
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0017 0.0037 0.0037
Echinococcus multilocularis methionyl aminopeptidase 1 (M24 family) 0.0022 0.0085 0.0085
Loa Loa (eye worm) hypothetical protein 0.0023 0.0092 0.0056
Echinococcus granulosus xaa Pro dipeptidase 0.0022 0.0085 0.0085
Echinococcus granulosus xaa pro aminopeptidase 0.0022 0.0085 0.0085
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0024 0.0104 0.069
Echinococcus multilocularis cyclins 0.004 0.0254 0.0254
Schistosoma mansoni tyrosine kinase 0.0034 0.0199 0.0199
Onchocerca volvulus 0.0017 0.0037 0.0003
Plasmodium falciparum methionine aminopeptidase 2 0.0177 0.1505 0.1556
Mycobacterium ulcerans transcriptional regulator 0.0066 0.0485 0.0435
Echinococcus granulosus survival motor neuron protein 1 0.0273 0.2388 0.2388
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0017 0.0037 0.0037
Loa Loa (eye worm) hypothetical protein 0.0069 0.0513 0.0478
Loa Loa (eye worm) hypothetical protein 0.0031 0.0172 0.0137
Loa Loa (eye worm) TK/FER protein kinase 0.0024 0.0104 0.0068
Loa Loa (eye worm) hypothetical protein 0.0039 0.0245 0.0209
Loa Loa (eye worm) TK/FER protein kinase 0.0024 0.0104 0.0068
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0071 0.0532 0.0451
Echinococcus multilocularis G protein coupled receptor kinase 1 0.0095 0.0759 0.0759
Brugia malayi hypothetical protein 0.0024 0.0104 0.0068
Brugia malayi Protein kinase domain containing protein 0.0024 0.0104 0.0068
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0071 0.0532 0.0485
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0018 0.0051 0.0015
Loa Loa (eye worm) hypothetical protein 0.0036 0.0209 0.0174
Echinococcus multilocularis cyclin b3 0.004 0.0254 0.0254
Wolbachia endosymbiont of Brugia malayi Mg/Co/Ni transporter MgtE 0.0066 0.0485 0.0403
Schistosoma mansoni growth factor receptor-bound protein 0.0173 0.1471 0.1471
Schistosoma mansoni serine/threonine protein kinase 0.0106 0.0859 0.0859
Schistosoma mansoni protein phosphatase 2C 0.0018 0.005 0.005
Entamoeba histolytica methionine aminopeptidase, putative 0.0177 0.1505 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0058 0.0412 0.0377
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0036 0.0209 0.0174
Schistosoma mansoni serine/threonine protein kinase 0.0065 0.0479 0.0479
Loa Loa (eye worm) hypothetical protein 0.0024 0.0104 0.0068
Echinococcus multilocularis geminin 0.0196 0.1678 0.1678
Brugia malayi Nuclear hormone receptor E75 0.0017 0.0037 0.0001
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.005 0.0341 0.0306
Brugia malayi Cytochrome P450 family protein 0.0018 0.0051 0.0016
Trypanosoma brucei cytochrome P450, putative 0.0018 0.0051 0.0002
Loa Loa (eye worm) hypothetical protein 0.0017 0.0037 0.0001
Loa Loa (eye worm) hypothetical protein 0.0017 0.0037 0.0001
Loa Loa (eye worm) cytochrome P450 family protein 0.0018 0.0051 0.0016
Trichomonas vaginalis cyclins, putative 0.0069 0.0513 0.1854
Trypanosoma cruzi Metallopeptidase family M24, putative 0.0022 0.0085 0.0035
Mycobacterium tuberculosis Conserved hypothetical membrane protein 0.0066 0.0485 0.0403
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0036 0.0209 0.0174
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0024 0.0104 0.0104
Schistosoma mansoni hypothetical protein 0.0023 0.0092 0.0092
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0036 0.0209 0.0174
Echinococcus granulosus Xaa Pro aminopeptidase 3 0.0022 0.0085 0.0085
Brugia malayi nuclear hormone receptor 0.0017 0.0037 0.0001
Echinococcus multilocularis cyclins 0.004 0.0254 0.0254
Giardia lamblia Kinase, CMGC CDK 0.005 0.0341 0.1801
Schistosoma mansoni jumonji domain containing protein 0.0068 0.0507 0.0507
Echinococcus multilocularis SH2 motif 0.0023 0.0092 0.0092
Trypanosoma cruzi Metallopeptidase family M24/FACT complex subunit (SPT16/CDC68)/Histone chaperone Rttp106-like, putative 0.0022 0.0085 0.0035
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0177 0.1505 0.6155
Schistosoma mansoni tyrosine kinase 0.0024 0.0104 0.0104
Loa Loa (eye worm) hypothetical protein 0.0066 0.0485 0.045
Loa Loa (eye worm) SRC-1 0.0034 0.0199 0.0163
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0034 0.0199 0.0199
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0036 0.0209 0.0209
Echinococcus granulosus phd:f box containing protein 0.0018 0.005 0.005
Loa Loa (eye worm) hypothetical protein 0.0017 0.0037 0.0001
Trypanosoma cruzi metallo- peptidase, Clan MG, Family M24 0.0022 0.0085 0.0035
Loa Loa (eye worm) TK/FER protein kinase 0.0024 0.0104 0.0068
Onchocerca volvulus 0.0023 0.0092 0.0139
Loa Loa (eye worm) hypothetical protein 0.0023 0.0092 0.0056
Loa Loa (eye worm) hypothetical protein 0.0023 0.0092 0.0056
Echinococcus multilocularis tensin 0.0031 0.0172 0.0172
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0017 0.0037 0.0037
Trypanosoma brucei Xaa-Pro aminopeptidase, putative 0.0022 0.0085 0.0035
Mycobacterium ulcerans dipeptidase PepE 0.0022 0.0085 0.0034
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0068 0.0507 0.0507
Loa Loa (eye worm) jmjC domain-containing protein 0.0068 0.0507 0.0472
Echinococcus multilocularis NCK adaptor protein 0.0033 0.0187 0.0187
Echinococcus multilocularis 0.0023 0.0092 0.0092
Echinococcus granulosus SNF4:AMP activated protein kinase gamma subunit 0.0066 0.0485 0.0485
Loa Loa (eye worm) initiation factor 2-associated protein 0.0177 0.1505 0.1474
Mycobacterium leprae Probable cystathionine beta-synthase CBS (Serine sulfhydrase) (Beta-thionase) (Hemoprotein H-450) 0.0066 0.0485 0.0403
Brugia malayi Protein kinase domain containing protein 0.0024 0.0104 0.0068
Loa Loa (eye worm) metallopeptidase family M24 containing protein 0.0022 0.0085 0.0049
Echinococcus granulosus H:Cl exchange transporter 3 0.0066 0.0485 0.0485
Onchocerca volvulus Putative GMP reductase 0.0459 0.4088 1
Loa Loa (eye worm) IMP dehydrogenase 1 0.1103 1 1
Treponema pallidum hemolysin (tlyC) 0.0066 0.0485 1
Schistosoma mansoni SH2A 0.0023 0.0092 0.0092
Echinococcus granulosus lamin dm0 0.0054 0.038 0.038
Echinococcus granulosus nuclear receptor nhr 48 0.0017 0.0037 0.0037
Loa Loa (eye worm) hypothetical protein 0.0022 0.0085 0.0049
Loa Loa (eye worm) TK/FER protein kinase 0.0024 0.0104 0.0068
Echinococcus granulosus tyrosine protein kinase Srms 0.0024 0.0104 0.0104
Loa Loa (eye worm) jmjC domain-containing protein 0.0018 0.005 0.0014
Brugia malayi ecdysteroid receptor 0.0036 0.0209 0.0174
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0018 0.0051 0.0051
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0033 0.0187 0.0152
Echinococcus multilocularis FACT complex subunit SPT16 0.0022 0.0085 0.0085
Mycobacterium ulcerans methionine aminopeptidase 0.0022 0.0085 0.0034
Schistosoma mansoni phd/f-box containing protein 0.0018 0.005 0.005
Trypanosoma cruzi cdc2-related kinase 3 0.005 0.0341 0.0292
Echinococcus multilocularis G2:mitotic specific cyclin B3 0.004 0.0254 0.0254
Mycobacterium leprae Probable inosine-5'-monophosphate dehydrogenase GuaB3 (IMP dehydrogenase 2) (inosinic acid dehydrogenase) (inosinate dehydrogena 0.0579 0.5195 0.5154
Loa Loa (eye worm) TK/FER protein kinase 0.0024 0.0104 0.0068
Onchocerca volvulus 0.0023 0.0092 0.0139
Trypanosoma cruzi cytochrome P450, putative 0.0018 0.0051 0.0002
Trichomonas vaginalis AGC family protein kinase 0.0065 0.0479 0.1708
Trichomonas vaginalis cyclins, putative 0.0069 0.0513 0.1854
Schistosoma mansoni steroid hormone receptor ad4bp 0.0036 0.0209 0.0209
Echinococcus multilocularis SH2 motif 0.0023 0.0092 0.0092
Loa Loa (eye worm) hypothetical protein 0.0019 0.0056 0.002
Echinococcus multilocularis cyclins 0.004 0.0254 0.0254
Echinococcus multilocularis cyclin dependent kinase 1 0.005 0.0341 0.0341
Entamoeba histolytica protein kinase, putative 0.0065 0.0479 0.3184
Schistosoma mansoni AMP-activated protein kinase gamma regulatory subunit 0.0066 0.0485 0.0485
Echinococcus multilocularis Ankyrin 0.0017 0.0037 0.0037
Plasmodium vivax SET domain protein, putative 0.0034 0.02 0.016
Echinococcus multilocularis cyclin dependent kinase 0.005 0.0341 0.0341
Schistosoma mansoni methionyl aminopeptidase 2 (M24 family) 0.0177 0.1505 0.1505
Schistosoma mansoni jumonji/arid domain-containing protein 0.0068 0.0507 0.0507
Onchocerca volvulus Protein ultraspiracle homolog 0.0036 0.0209 0.0428
Plasmodium vivax methionine aminopeptidase 2, putative 0.0177 0.1505 0.1556
Entamoeba histolytica cyclin family protein 0.004 0.0254 0.1687
Brugia malayi jmjC domain containing protein 0.0018 0.005 0.0014
Plasmodium falciparum FACT complex subunit SPT16, putative 0.0022 0.0085 0.0038
Toxoplasma gondii aurora kinase 0.0065 0.0479 0.0431
Echinococcus multilocularis nuclear receptor nhr 48 0.0017 0.0037 0.0037
Brugia malayi nuclear receptor RXR 0.0019 0.0056 0.002
Brugia malayi jmjC domain containing protein 0.0068 0.0507 0.0472
Loa Loa (eye worm) hypothetical protein 0.0019 0.0056 0.002
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0017 0.0037 0.0037
Trypanosoma cruzi metallo-peptidase, Clan MG, Family M24 0.0022 0.0085 0.0035
Echinococcus granulosus FACT complex subunit SPT16 0.0022 0.0085 0.0085
Brugia malayi ecdysone receptor 0.0017 0.0037 0.0001
Trypanosoma brucei metallo-peptidase, Clan MG, Family M24 0.0022 0.0085 0.0035
Onchocerca volvulus 0.0023 0.0092 0.0139
Schistosoma mansoni adapter molecule crk 0.0033 0.0187 0.0187
Echinococcus multilocularis musashi 0.0054 0.038 0.038
Mycobacterium tuberculosis Probable cystathionine beta-synthase Cbs (serine sulfhydrase) (beta-thionase) (hemoprotein H-450) 0.0066 0.0485 0.0403
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0026 0.0123 0.0123
Loa Loa (eye worm) chloride channel protein 7 0.0066 0.0485 0.045
Echinococcus granulosus AMP activated protein kinase gamma regulatory 0.0066 0.0485 0.0485
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0034 0.02 0.0151
Schistosoma mansoni RAR-like nuclear receptor 0.0036 0.0209 0.0209
Echinococcus granulosus SHC transforming protein 3 0.0031 0.0172 0.0172
Trypanosoma cruzi chloride channel protein, putative 0.0066 0.0485 0.0437
Wolbachia endosymbiont of Brugia malayi Mg2+/Co2+ transporter 0.0066 0.0485 0.0403
Onchocerca volvulus 0.0017 0.0037 0.0003
Toxoplasma gondii peptidase D, putative 0.0022 0.0085 0.0035
Onchocerca volvulus 0.0024 0.0104 0.0167
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0036 0.0209 0.0209
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0036 0.0209 0.0174
Brugia malayi serine/threonine protein kinase 6 0.0065 0.0479 0.0445
Loa Loa (eye worm) cytokine inducible SH2-containing protein 5 0.0023 0.0092 0.0056
Echinococcus multilocularis xaa Pro dipeptidase 0.0022 0.0085 0.0085
Loa Loa (eye worm) hypothetical protein 0.0031 0.0164 0.0128
Echinococcus multilocularis thyroid hormone receptor alpha 0.0036 0.0209 0.0209
Echinococcus granulosus Proliferation associated protein 2G4 0.0022 0.0085 0.0085
Chlamydia trachomatis Mg++ transporter 0.0066 0.0485 1
Echinococcus multilocularis cyclins 0.004 0.0254 0.0254
Giardia lamblia Manganese-dependent inorganic pyrophosphatase, putative 0.0066 0.0485 0.2813
Echinococcus granulosus lamin 0.0054 0.038 0.038
Echinococcus granulosus cyclin dependent kinase 5 0.005 0.0341 0.0341
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0017 0.0037 0.0001
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0018 0.0051 0.0051
Schistosoma mansoni intermediate filament proteins 0.0054 0.038 0.038
Wolbachia endosymbiont of Brugia malayi hemolysin 0.0066 0.0485 0.0403
Leishmania major aminopeptidase P1, putative,metallo-peptidase, Clan MG, Family M24 0.0022 0.0085 0.0035
Schistosoma mansoni ankyrin 23/unc44 0.0017 0.0036 0.0036
Plasmodium vivax peptidase, putative 0.0022 0.0085 0.0038
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0033 0.0187 0.0187
Brugia malayi Intermediate filament tail domain containing protein 0.0054 0.038 0.0346
Onchocerca volvulus 0.0066 0.0485 0.1107
Trypanosoma cruzi metallo-peptidase, Clan MG, Family M24 0.0177 0.1505 0.1462
Entamoeba histolytica cyclin, putative 0.004 0.0254 0.1687
Brugia malayi Protein kinase domain containing protein 0.0018 0.0048 0.0012
Schistosoma mansoni vav2 0.0025 0.0114 0.0114
Loa Loa (eye worm) hypothetical protein 0.0036 0.0209 0.0174
Brugia malayi DNA-binding protein, 42 kDa containing protein 0.0022 0.0085 0.0049
Echinococcus multilocularis phosphatidylinositol 3 kinase regulatory subunit 0.0023 0.0092 0.0092
Leishmania major protein kinase, putative 0.0065 0.0479 0.0431
Echinococcus multilocularis H(+):Cl() exchange transporter 4 0.0066 0.0485 0.0485
Loa Loa (eye worm) hypothetical protein 0.0019 0.0056 0.002
Trypanosoma brucei metallo-peptidase, Clan MG, Family M24 0.0022 0.0085 0.0035
Trypanosoma cruzi cdc2-related kinase 1 0.005 0.0341 0.0292
Echinococcus multilocularis tyrosine protein kinase Abl 0.0034 0.0199 0.0199
Loa Loa (eye worm) hypothetical protein 0.0066 0.0485 0.045
Echinococcus granulosus hypothetical protein 0.0023 0.0092 0.0092
Echinococcus granulosus cyclins 0.004 0.0254 0.0254
Brugia malayi SH2 domain containing protein 0.0024 0.0104 0.0068
Schistosoma mansoni cyclin B 0.0069 0.0513 0.0513
Trypanosoma brucei methionine aminopeptidase 2, putative 0.0177 0.1505 0.1462
Echinococcus granulosus Nuclear hormone receptor HR96 0.0017 0.0037 0.0037
Echinococcus multilocularis tyrosine protein kinase Blk 0.0024 0.0104 0.0104
Loa Loa (eye worm) hypothetical protein 0.0023 0.0092 0.0056
Brugia malayi tRNA modification GTPase TrmE family protein 0.0023 0.0092 0.0056
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0036 0.0209 0.0174
Schistosoma mansoni phosphatidylserine receptor 0.0018 0.005 0.005
Loa Loa (eye worm) hypothetical protein 0.0053 0.0371 0.0336
Brugia malayi hypothetical protein 0.0019 0.0056 0.002
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0018 0.0051 0.0051
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0026 0.0123 0.0123
Schistosoma mansoni proliferation-associated protein 2G4 38kDa (M24 family) 0.0022 0.0085 0.0085
Loa Loa (eye worm) cytochrome P450 family protein 0.0018 0.0051 0.0016
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0071 0.0532 0.0532
Loa Loa (eye worm) hypothetical protein 0.0017 0.0037 0.0001
Onchocerca volvulus FACT complex subunit SPT16 homolog 0.0022 0.0085 0.0121
Echinococcus granulosus FTZ F1 alpha 0.0036 0.0209 0.0209
Entamoeba histolytica hypothetical protein 0.0072 0.0546 0.3629
Echinococcus granulosus tyrosine protein kinase Fyn 0.0034 0.0199 0.0199
Trypanosoma brucei metallo- peptidase, Clan MG, Family M24 0.0022 0.0085 0.0035
Loa Loa (eye worm) DNA-binding protein 0.0022 0.0085 0.0049
Mycobacterium leprae conserved hypothetical protein 0.0066 0.0485 0.0403
Loa Loa (eye worm) hypothetical protein 0.0069 0.0513 0.0478
Echinococcus granulosus tyrosine protein kinase Src64B 0.0034 0.0199 0.0199
Loa Loa (eye worm) hypothetical protein 0.0273 0.2388 0.236
Echinococcus multilocularis xaa Pro dipeptidase 0.0022 0.0085 0.0085
Giardia lamblia G2/mitotic-specific cyclin B 0.0069 0.0513 0.3012
Schistosoma mansoni tensin 0.0023 0.0092 0.0092
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0034 0.0199 0.0199
Brugia malayi Variant SH3 domain containing protein 0.0033 0.0187 0.0152
Loa Loa (eye worm) nuclear receptor NHR-67 0.0017 0.0037 0.0001
Onchocerca volvulus 0.0054 0.038 0.085
Schistosoma mansoni tensin 0.0023 0.0092 0.0092
Trypanosoma cruzi metallo-peptidase, Clan MG, Family M24 0.0022 0.0085 0.0035
Loa Loa (eye worm) hypothetical protein 0.0028 0.0143 0.0107
Mycobacterium ulcerans methionine aminopeptidase MapB 0.0022 0.0085 0.0034
Loa Loa (eye worm) hypothetical protein 0.0023 0.0092 0.0056
Loa Loa (eye worm) loechrig isoform VII 0.0066 0.0485 0.045
Brugia malayi nuclear hormone receptor family member odr-7 0.0017 0.0037 0.0001
Echinococcus granulosus tyrosine protein kinase ABL1 0.0024 0.0104 0.0104
Entamoeba histolytica cyclin family protein 0.004 0.0254 0.1687
Plasmodium falciparum methionine aminopeptidase 1a, putative 0.0022 0.0085 0.0038
Schistosoma mansoni tyrosine kinase 0.0034 0.0199 0.0199
Echinococcus granulosus cyclin B3 1 0.004 0.0254 0.0254
Schistosoma mansoni lamin 0.0054 0.038 0.038
Brugia malayi Tensin 0.0023 0.0092 0.0056
Echinococcus granulosus SH2 motif 0.0023 0.0092 0.0092
Echinococcus granulosus cyclins 0.004 0.0254 0.0254
Trypanosoma brucei cdc2-related kinase 1 0.005 0.0341 0.0292
Chlamydia trachomatis CBS domain-containing protein 0.0066 0.0485 1
Loa Loa (eye worm) hypothetical protein 0.0066 0.0485 0.045
Brugia malayi loechrig isoform VII 0.0066 0.0485 0.045
Onchocerca volvulus 0.0056 0.0394 0.0885
Leishmania major guanosine monophosphate reductase 0.1103 1 1
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0085 0.0664 0.0664
Schistosoma mansoni tyrosine kinase 0.0024 0.0105 0.0105
Leishmania major cyclin 0.0069 0.0513 0.0465
Brugia malayi nuclear receptor NHR-88 0.0017 0.0037 0.0001
Echinococcus multilocularis methionyl aminopeptidase 1 (M24 family) 0.0022 0.0085 0.0085
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0173 0.1471 0.144
Brugia malayi Cyclin, N-terminal domain containing protein 0.004 0.0254 0.0219
Brugia malayi nuclear receptor NHR-88 0.0036 0.0209 0.0174
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0036 0.0209 0.0209
Echinococcus multilocularis aurora kinase A 0.0065 0.0479 0.0479
Brugia malayi Steroid receptor seven-up type 2 0.0036 0.0209 0.0174
Echinococcus granulosus beta-adrenergic receptor kinase 0.0106 0.0859 0.0859
Echinococcus multilocularis SH2 domain containing protein 7 0.0023 0.0092 0.0092
Echinococcus granulosus tyrosine protein kinase Lyn 0.0036 0.0211 0.0211
Trypanosoma cruzi metallo-peptidase, Clan MG, Family M24, putative 0.0022 0.0085 0.0035
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.0159 0.1345 0.1345
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0034 0.0199 0.0199
Echinococcus multilocularis cyclins 0.004 0.0254 0.0254
Schistosoma mansoni aminopeptidase P homologue (M24 family) 0.0022 0.0085 0.0085
Echinococcus granulosus thyroid hormone receptor alpha 0.0017 0.0037 0.0037
Schistosoma mansoni retinoic acid receptor RXR 0.0036 0.0209 0.0209
Loa Loa (eye worm) AUR protein kinase 0.0065 0.0479 0.0445
Echinococcus multilocularis cyclin dependent kinase 1 0.005 0.0341 0.0341
Schistosoma mansoni hypothetical protein 0.0023 0.0092 0.0092
Brugia malayi Tyrosine-protein kinase abl-1 0.0034 0.0199 0.0163
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0106 0.0859 0.0826
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0071 0.0532 0.0483
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.005 0.0341 0.0341
Echinococcus granulosus cyclin B 0.0069 0.0513 0.0513
Trichomonas vaginalis cyclins, putative 0.0069 0.0513 0.1854
Echinococcus multilocularis growth factor receptor bound protein 2 0.0173 0.1471 0.1471
Giardia lamblia Cyclin A 0.004 0.0254 0.1189
Trichomonas vaginalis AGC family protein kinase 0.0065 0.0479 0.1708
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.1103 1 1
Toxoplasma gondii hypothetical protein 0.0031 0.0165 0.0115
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0024 0.0104 0.0692
Brugia malayi RhoGAP domain containing protein 0.0023 0.0092 0.0056
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0036 0.0209 0.0174
Trypanosoma cruzi GMP reductase 0.1103 1 1
Onchocerca volvulus Bile acid receptor homolog 0.0036 0.0209 0.0428
Brugia malayi SH2 domain containing protein 0.0023 0.0092 0.0056
Mycobacterium tuberculosis Hypoxic response protein 1 Hrp1 0.0066 0.0485 0.0403
Brugia malayi Protein kinase domain containing protein 0.0024 0.0104 0.0068
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0072 0.0546 0.0546
Trypanosoma brucei methionine aminopeptidase, type I, putative 0.0022 0.0085 0.0035
Loa Loa (eye worm) hypothetical protein 0.0018 0.005 0.0014
Schistosoma mansoni inosine-5-monophosphate dehydrogenase 0.1103 1 1
Trypanosoma brucei Voltage-gated Chloride channel Like 3 0.0066 0.0485 0.0437
Echinococcus granulosus lysine specific demethylase 5A 0.0068 0.0507 0.0507
Brugia malayi serine/threonine-protein kinase 6 0.0065 0.0479 0.0445
Loa Loa (eye worm) TK/FER protein kinase 0.0024 0.0104 0.0068
Loa Loa (eye worm) jmjC domain-containing protein 0.0018 0.005 0.0014
Trypanosoma cruzi cyclin 6, putative 0.0069 0.0513 0.0465
Echinococcus granulosus cyclins 0.004 0.0254 0.0254
Schistosoma mansoni jumonji domain containing protein 0.0018 0.005 0.005
Schistosoma mansoni hypothetical protein 0.0018 0.0051 0.0051
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0034 0.0199 0.0199
Brugia malayi nuclear hormone receptor family member nhr-6 0.0017 0.0037 0.0001
Trypanosoma cruzi cyclin, putative 0.0069 0.0513 0.0465
Echinococcus multilocularis survival motor neuron protein 1 0.0273 0.2388 0.2388
Trichomonas vaginalis AGC family protein kinase 0.0065 0.0479 0.1708
Leishmania major aminopeptidase P1, putative,metallo-peptidase, Clan MG, Family M24 0.0022 0.0085 0.0035
Echinococcus multilocularis cyclins 0.004 0.0254 0.0254
Giardia lamblia Methionine aminopeptidase 0.0177 0.1505 1
Echinococcus granulosus suppressor of cytokine signaling 6 0.0023 0.0092 0.0092
Echinococcus granulosus cyclins 0.004 0.0254 0.0254
Trypanosoma cruzi chloride channel protein, putative 0.0066 0.0485 0.0437
Mycobacterium ulcerans cystathionine beta-synthase 0.0066 0.0485 0.0435
Echinococcus multilocularis methionine aminopeptidase, type I 0.0022 0.0085 0.0085
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0254 0.0732
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0036 0.0209 0.0209
Echinococcus granulosus SH2 domain containing protein 7 0.0023 0.0092 0.0092
Brugia malayi Protein kinase domain containing protein 0.005 0.0341 0.0306
Loa Loa (eye worm) hypothetical protein 0.0066 0.0485 0.045
Echinococcus granulosus cyclin dependent kinase 0.005 0.0341 0.0341
Entamoeba histolytica protein kinase, putative 0.0024 0.0104 0.0692
Schistosoma mansoni methionyl aminopeptidase 1 (M24 family) 0.0022 0.0085 0.0085
Brugia malayi chloride channel protein 7 0.0066 0.0485 0.045
Brugia malayi nuclear receptor RXR 0.0017 0.0037 0.0001
Loa Loa (eye worm) hypothetical protein 0.0017 0.0037 0.0001
Echinococcus multilocularis JmjC domain containing protein 4 0.0018 0.005 0.005
Brugia malayi hypothetical protein 0.0017 0.0037 0.0001
Trichomonas vaginalis cyclins, putative 0.0069 0.0513 0.1854
Echinococcus granulosus tyrosine kinase 0.0024 0.0104 0.0104
Echinococcus multilocularis tyrosine protein kinase shark 0.0024 0.0105 0.0105
Plasmodium falciparum inosine-5'-monophosphate dehydrogenase 0.1038 0.9399 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.0092 0.0056
Schistosoma mansoni suppressor of cytokine signaling 0.0023 0.0092 0.0092
Echinococcus multilocularis lysine specific demethylase 6a 0.0018 0.005 0.005
Toxoplasma gondii chloride transporter, chloride channel (ClC) family protein 0.0066 0.0485 0.0437
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0017 0.0037 0.0037
Mycobacterium ulcerans hypothetical protein 0.0066 0.0485 0.0435
Brugia malayi SH2 domain containing protein 0.0023 0.0092 0.0056
Schistosoma mansoni coup transcription factor 0.0036 0.0209 0.0209
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0036 0.0209 0.0174
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0024 0.0104 0.0104
Trypanosoma cruzi Domain of unknown function DUF21, putative 0.0066 0.0485 0.0437
Brugia malayi ancient conserved domain protein 2 0.0066 0.0485 0.045
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.02 0.02
Echinococcus granulosus signal transduction protein lnk realted 0.0023 0.0092 0.0092
Loa Loa (eye worm) hypothetical protein 0.0036 0.0209 0.0174
Loa Loa (eye worm) latrophilin receptor protein 2 0.0018 0.0051 0.0015
Loa Loa (eye worm) hypothetical protein 0.0019 0.0056 0.002
Brugia malayi orphan nuclear receptor NR2E1 0.0017 0.0037 0.0001
Mycobacterium leprae Probable inosine-5'-monophosphate dehydrogenase GuaB2 (IMP dehydrogenase) (IMPDH) (IMPD) 0.1103 1 1
Giardia lamblia 5-AMP-activated protein kinase, gamma-1 subunit 0.0066 0.0485 0.2813
Schistosoma mansoni nuclear hormone receptor 0.0017 0.0037 0.0037
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0036 0.0209 0.0209
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0072 0.0546 0.0546
Schistosoma mansoni proliferation-associated protein 2G4 38kDa (M24 family) 0.0022 0.0085 0.0085
Leishmania major aminopeptidase P1, putative,metallo-peptidase, Clan MG, Family M24 0.0022 0.0085 0.0035
Schistosoma mansoni hypothetical protein 0.0196 0.1678 0.1678
Onchocerca volvulus 0.0023 0.0092 0.0139
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0071 0.0532 0.0498
Loa Loa (eye worm) hypothetical protein 0.0033 0.0187 0.0152
Brugia malayi latrophilin 2 splice variant baaae 0.0039 0.0245 0.0209
Trypanosoma cruzi metallo-peptidase, Clan MG, Family M24, putative 0.0022 0.0085 0.0035
Brugia malayi tailless protein 0.0017 0.0037 0.0001
Loa Loa (eye worm) hypothetical protein 0.0022 0.0085 0.0049
Toxoplasma gondii methionine aminopeptidase 0.0022 0.0085 0.0035
Brugia malayi SH2 domain containing protein 0.0023 0.0092 0.0056
Brugia malayi Cytochrome P450 family protein 0.0018 0.0051 0.0016
Schistosoma mansoni tensin 0.0023 0.0092 0.0092
Onchocerca volvulus 0.0022 0.0085 0.0121
Mycobacterium ulcerans inosine 5-monophosphate dehydrogenase 0.0524 0.4689 0.4661
Echinococcus granulosus Ankyrin 0.0017 0.0037 0.0037
Schistosoma mansoni AMP-activated protein kinase gamma regulatory subunit 0.0066 0.0485 0.0485
Echinococcus multilocularis tensin 0.0023 0.0092 0.0092
Plasmodium vivax methionine aminopeptidase 1c, putative 0.0022 0.0085 0.0038
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.1103 1 1
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0036 0.0209 0.0174
Echinococcus granulosus tyrosine protein kinase Src42A 0.0034 0.0199 0.0199
Loa Loa (eye worm) hypothetical protein 0.0017 0.0037 0.0001
Brugia malayi Nuclear hormone receptor E75 0.0017 0.0037 0.0001
Echinococcus granulosus cyclin b3 0.004 0.0254 0.0254
Schistosoma mansoni chloride channel protein 0.0066 0.0485 0.0485
Loa Loa (eye worm) nuclear hormone receptor 0.0017 0.0037 0.0001
Schistosoma mansoni nuclear hormone receptor 0.0036 0.0209 0.0209
Loa Loa (eye worm) hypothetical protein 0.0023 0.0092 0.0056
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0034 0.02 0.02
Toxoplasma gondii CBS domain-containing protein 0.0066 0.0485 0.0437
Trichomonas vaginalis cyclin B3, putative 0.004 0.0254 0.0732
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0036 0.0209 0.0209
Schistosoma mansoni aminopeptidase P1 (M24 family) 0.0022 0.0085 0.0085
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0065 0.0479 0.0479
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0023 0.0092 0.0092
Schistosoma mansoni tyrosine-protein kinase zap-70 0.0023 0.0092 0.0092
Giardia lamblia Manganese-dependent inorganic pyrophosphatase, putative 0.0066 0.0485 0.2813
Trypanosoma brucei cdc2-related kinase 3 0.005 0.0341 0.0292
Schistosoma mansoni transcription factor LCR-F1 0.0072 0.0546 0.0546
Echinococcus multilocularis beta adrenergic receptor kinase 0.0106 0.0859 0.0859
Schistosoma mansoni zinc finger protein 0.0017 0.0037 0.0037
Echinococcus granulosus methionyl aminopeptidase 1 M24 family 0.0022 0.0085 0.0085
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0036 0.0209 0.0174
Onchocerca volvulus Suppressor of cytokine signaling at 36E homolog 0.0023 0.0092 0.0139
Brugia malayi Pre-SET motif family protein 0.024 0.2087 0.2059
Echinococcus granulosus Nuclear hormone receptor HR96 0.0017 0.0037 0.0037
Loa Loa (eye worm) TK/FER protein kinase 0.0024 0.0104 0.0068
Loa Loa (eye worm) hypothetical protein 0.0023 0.0092 0.0056
Brugia malayi Variant SH3 domain containing protein 0.0023 0.0092 0.0056
Loa Loa (eye worm) GMP reductase 0.0459 0.4088 0.4066
Echinococcus granulosus G2:mitotic specific cyclin B3 0.004 0.0254 0.0254
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0036 0.0209 0.0174
Loa Loa (eye worm) cyclin domain-containing protein 0.004 0.0254 0.0219
Loa Loa (eye worm) hypothetical protein 0.0023 0.0092 0.0056
Loa Loa (eye worm) hypothetical protein 0.0017 0.0037 0.0001
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0036 0.0209 0.0174
Echinococcus multilocularis jumonji domain containing 1A 0.0018 0.005 0.005
Loa Loa (eye worm) hypothetical protein 0.0036 0.0209 0.0174
Toxoplasma gondii methionine aminopeptidase 0.0022 0.0085 0.0035
Brugia malayi SH2 domain containing protein 0.0023 0.0092 0.0056
Plasmodium vivax methionine aminopeptidase 1b, putative 0.0022 0.0085 0.0038
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0024 0.0104 0.0104
Brugia malayi conserved hypotetical protein 0.0017 0.0037 0.0001
Loa Loa (eye worm) TK/FER protein kinase 0.0024 0.0104 0.0068
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0017 0.0037 0.0037
Brugia malayi Nuclear hormone receptor-like 1 0.0036 0.0209 0.0174
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0159 0.1345 0.1345
Schistosoma mansoni nuclear receptor nhr-48 0.0017 0.0037 0.0037
Entamoeba histolytica protein kinase, putative 0.0065 0.0479 0.3184
Onchocerca volvulus 0.0024 0.0104 0.0167
Echinococcus granulosus N chimaerin 0.0023 0.0092 0.0092
Leishmania major chloride channel protein, putative 0.0066 0.0485 0.0437
Brugia malayi jmjC domain containing protein 0.0068 0.0507 0.0472
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0017 0.0037 0.0037
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0019 0.0056 0.0056
Echinococcus granulosus histone lysine methyltransferase setb 0.0034 0.02 0.02
Echinococcus multilocularis Proliferation associated protein 2G4 0.0022 0.0085 0.0085
Echinococcus multilocularis tyrosine protein kinase Srms 0.0024 0.0104 0.0104
Mycobacterium tuberculosis Probable conserved transmembrane protein 0.0066 0.0485 0.0403
Entamoeba histolytica Xaa-Pro dipeptidase, putative 0.0022 0.0085 0.0565
Loa Loa (eye worm) hypothetical protein 0.0018 0.005 0.0014
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0341 0.1109
Brugia malayi Pre-SET motif family protein 0.0034 0.02 0.0164
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0036 0.0209 0.0209
Echinococcus granulosus lysine specific demethylase 6a 0.0018 0.005 0.005
Plasmodium falciparum proliferation-associated protein 2g4, putative 0.0022 0.0085 0.0038
Brugia malayi hypothetical protein 0.0019 0.0056 0.002
Echinococcus multilocularis suppressor of cytokine signaling 6 0.0023 0.0092 0.0092
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.0065 0.0479 0.3184
Brugia malayi initiation factor 2-associated protein. 0.0177 0.1505 0.1474
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0017 0.0037 0.0037
Brugia malayi Cyclin, N-terminal domain containing protein 0.0069 0.0513 0.0478
Onchocerca volvulus 0.0024 0.0104 0.0167
Echinococcus granulosus intermediate filament protein 0.0054 0.038 0.038
Echinococcus multilocularis SH2 domain containing adapter protein F 0.0023 0.0092 0.0092
Entamoeba histolytica hypothetical protein 0.0072 0.0546 0.3629
Echinococcus multilocularis netrin receptor unc 5 0.0017 0.0036 0.0036
Plasmodium vivax proliferation-associated protein 2g4, putative 0.0022 0.0085 0.0038
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.1103 1 1
Loa Loa (eye worm) CYP4Cod1 0.0018 0.0051 0.0016
Entamoeba histolytica hypothetical protein 0.0072 0.0546 0.3629
Schistosoma mansoni methionyl aminopeptidase 1 (M24 family) 0.0022 0.0085 0.0085
Schistosoma mansoni cyclin B3 0.004 0.0254 0.0254
Echinococcus granulosus tyrosine protein kinase Src42A 0.0023 0.0092 0.0092
Leishmania major transcription factor-like protein 0.0022 0.0085 0.0035
Echinococcus multilocularis lamin 0.0054 0.038 0.038
Echinococcus granulosus tyrosine protein kinase Fyn 0.0034 0.0199 0.0199
Entamoeba histolytica hypothetical protein, conserved 0.0022 0.0085 0.0565
Trichomonas vaginalis cyclin B, putative 0.0069 0.0513 0.1854
Trypanosoma brucei GMP reductase 0.1103 1 1
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.024 0.2087 0.2059
Echinococcus multilocularis N chimaerin 0.0023 0.0092 0.0092
Loa Loa (eye worm) jmjC domain-containing protein 0.0018 0.005 0.0014
Schistosoma mansoni survival motor neuron protein 0.0056 0.0394 0.0394
Echinococcus granulosus tyrosine protein kinase Fyn 0.0034 0.0199 0.0199
Toxoplasma gondii transcriptional elongation factor FACT140 0.0022 0.0085 0.0035
Plasmodium vivax FACT complex subunit SPT16, putative 0.0022 0.0085 0.0038
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0034 0.0199 0.0199
Trichomonas vaginalis cyclin B, putative 0.0069 0.0513 0.1854
Schistosoma mansoni nuclear receptor 0.0017 0.0037 0.0037
Brugia malayi metallopeptidase family M24 containing protein 0.0022 0.0085 0.0049
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0034 0.0199 0.0199
Loa Loa (eye worm) hypothetical protein 0.0017 0.0037 0.0001
Trypanosoma brucei inosine-5'-monophosphate dehydrogenase 0.1103 1 1
Trichomonas vaginalis cyclin B, putative 0.0069 0.0513 0.1854
Schistosoma mansoni hypothetical protein 0.0196 0.1678 0.1678
Brugia malayi Variant SH3 domain containing protein 0.0033 0.0187 0.0152
Loa Loa (eye worm) hypothetical protein 0.0036 0.0209 0.0174
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0036 0.0209 0.0209
Mycobacterium tuberculosis Probable inosine-5'-monophosphate dehydrogenase GuaB2 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase 0.1103 1 1
Entamoeba histolytica aminopeptidase, putative 0.0022 0.0085 0.0565
Mycobacterium ulcerans hypothetical protein 0.0066 0.0485 0.0435
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0023 0.0092 0.0092
Echinococcus multilocularis methionyl aminopeptidase 2 0.0177 0.1505 0.1505
Trypanosoma cruzi AMP-activated protein kinase, gamma regulatory subunit 0.0066 0.0485 0.0437
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0017 0.0036 0.0036
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0024 0.0104 0.0104
Schistosoma mansoni thyroid hormone receptor 0.0036 0.0209 0.0209
Loa Loa (eye worm) STAT protein 0.0023 0.0092 0.0056
Echinococcus multilocularis tyrosine kinase 0.0024 0.0104 0.0104
Schistosoma mansoni chloride channel protein 0.0066 0.0485 0.0485
Trypanosoma cruzi chloride channel protein, putative 0.0066 0.0485 0.0437
Toxoplasma gondii CBS family protein 0.0066 0.0485 0.0437
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative 0.0069 0.0513 0.0465
Trypanosoma cruzi UDP-glucoronosyl and UDP-glucosyl transferase, putative 0.0031 0.0164 0.0114
Onchocerca volvulus 0.0036 0.0209 0.0428
Echinococcus granulosus death domain containing protein 0.0017 0.0036 0.0036
Entamoeba histolytica cell division protein kinase 2, putative 0.005 0.0341 0.2265
Schistosoma mansoni protein kinase 0.0065 0.0479 0.0479
Trypanosoma cruzi GMP reductase 0.1103 1 1
Brugia malayi Nuclear hormone receptor-like 1 0.0019 0.0056 0.002
Onchocerca volvulus 0.0034 0.02 0.0404
Treponema pallidum Mg2+ transport protein (mgtE) 0.0066 0.0485 1
Echinococcus granulosus tensin C1 domain containing phosphatase 0.0023 0.0092 0.0092
Echinococcus granulosus geminin 0.0196 0.1678 0.1678
Leishmania major chloride channel protein, putative 0.0066 0.0485 0.0437
Echinococcus granulosus aurora kinase A 0.0065 0.0479 0.0479
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0036 0.0209 0.0209
Trypanosoma cruzi cdc2-related kinase 1 0.005 0.0341 0.0292
Brugia malayi SH2 domain containing protein 0.0024 0.0104 0.0068
Echinococcus multilocularis phd:f box containing protein 0.0018 0.005 0.005
Loa Loa (eye worm) hypothetical protein 0.0018 0.0051 0.0015
Brugia malayi CLC chloride channel protein 0.0066 0.0485 0.045
Brugia malayi Protein kinase domain containing protein 0.0024 0.0104 0.0068
Entamoeba histolytica peptidase, putative 0.0022 0.0085 0.0565
Mycobacterium ulcerans hypothetical protein 0.0066 0.0485 0.0435
Loa Loa (eye worm) TK/FER protein kinase 0.0024 0.0104 0.0068
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0017 0.0037 0.0037
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0036 0.0209 0.0174
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.005 0.0341 0.0306
Loa Loa (eye worm) hypothetical protein 0.0017 0.0037 0.0001
Wolbachia endosymbiont of Brugia malayi IMP dehydrogenase 0.1103 1 1
Loa Loa (eye worm) hypothetical protein 0.0054 0.038 0.0346
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0054 0.038 0.0346
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0036 0.0209 0.0209
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0034 0.0199 0.0199
Schistosoma mansoni chromatin-specific transcription elongation factor 140 kDa subunit (M24 family) 0.0022 0.0085 0.0085
Trypanosoma cruzi cyclin, putative 0.0069 0.0513 0.0465
Trypanosoma brucei Voltage-gated Chloride channel Like 1 0.0066 0.0485 0.0437
Loa Loa (eye worm) hypothetical protein 0.0025 0.0114 0.0079
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0018 0.005 0.005
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0023 0.0092 0.0092
Loa Loa (eye worm) methionine aminopeptidase type I 0.0022 0.0085 0.0049
Schistosoma mansoni hypothetical protein 0.0039 0.0245 0.0245
Brugia malayi Variant SH3 domain containing protein 0.0025 0.0114 0.0078
Trypanosoma brucei methionine aminopeptidase, putative 0.0022 0.0085 0.0035
Echinococcus multilocularis xaa pro aminopeptidase 0.0022 0.0085 0.0085
Plasmodium falciparum methionine aminopeptidase 1b, putative 0.0022 0.0085 0.0038
Echinococcus granulosus xaa Pro dipeptidase 0.0022 0.0085 0.0085
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0023 0.0092 0.0092
Schistosoma mansoni thyroid hormone receptor 0.0036 0.0209 0.0209
Echinococcus multilocularis FTZ F1 alpha 0.0036 0.0209 0.0209
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0025 0.0114 0.0078
Echinococcus granulosus tyrosine protein kinase Blk 0.0024 0.0104 0.0104
Entamoeba histolytica SH2 domain containing protein 0.0023 0.0092 0.0612
Loa Loa (eye worm) hypothetical protein 0.0026 0.0123 0.0088
Brugia malayi jmjC domain containing protein 0.0018 0.005 0.0014
Trypanosoma cruzi aminopeptidase P1, putative 0.0022 0.0085 0.0035
Brugia malayi SH2 domain containing protein 0.0023 0.0092 0.0056
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0034 0.0199 0.0199
Brugia malayi Cyclin, N-terminal domain containing protein 0.0069 0.0513 0.0478
Echinococcus multilocularis GPCR, family 2 0.0018 0.0051 0.0051
Echinococcus multilocularis SHC transforming protein 3 0.0031 0.0172 0.0172
Leishmania major CBS domain protein, conserved 0.0066 0.0485 0.0437
Loa Loa (eye worm) hypothetical protein 0.0036 0.0209 0.0174
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0341 0.1109
Schistosoma mansoni shc transforming protein 0.0031 0.0172 0.0172
Schistosoma mansoni serine/threonine protein kinase 0.005 0.0341 0.0341
Echinococcus granulosus tyrosine protein kinase shark 0.0024 0.0105 0.0105
Schistosoma mansoni Xaa-Pro dipeptidase (M24 family) 0.0022 0.0085 0.0085
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.02 0.02
Brugia malayi cytoplasmic intermediate filament protein 0.0029 0.015 0.0114
Trypanosoma cruzi cdc2-related kinase 3 0.005 0.0341 0.0292
Echinococcus granulosus phosphatidylinositol 3 kinase regulatory subunit 0.0023 0.0092 0.0092
Brugia malayi hypothetical protein 0.0273 0.2388 0.236
Trypanosoma cruzi cytochrome P450, putative 0.0018 0.0051 0.0002
Trypanosoma cruzi aurora B kinase, putative 0.0065 0.0479 0.0431
Echinococcus granulosus SH2 motif 0.0023 0.0092 0.0092
Schistosoma mansoni tensin-related 0.0031 0.0172 0.0172
Brugia malayi intermediate filament protein 0.0054 0.038 0.0346
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0018 0.0051 0.0051
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0019 0.0056 0.0056
Leishmania major cytochrome p450-like protein 0.0018 0.0051 0.0002
Onchocerca volvulus Suppressor of cytokine signaling 7 homolog 0.0023 0.0092 0.0139
Leishmania major hypothetical protein, conserved 0.0022 0.0085 0.0035
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0034 0.02 0.02
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0017 0.0037 0.0003
Brugia malayi CBS domain containing protein 0.0066 0.0485 0.045
Brugia malayi Nuclear hormone receptor-like 1 0.0019 0.0056 0.002
Echinococcus granulosus netrin receptor unc 5 0.0017 0.0036 0.0036
Onchocerca volvulus 0.0069 0.0513 0.1176
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0159 0.1345 0.1345
Trypanosoma brucei Facilitates chromatin transcription complex subunit spt16 0.0022 0.0085 0.0035
Echinococcus granulosus growth factor receptor bound protein 2 0.0173 0.1471 0.1471
Mycobacterium tuberculosis Conserved protein 0.0066 0.0485 0.0403
Brugia malayi photoreceptor-specific nuclear receptor 0.0036 0.0209 0.0174
Trypanosoma brucei aurora B kinase 0.0065 0.0479 0.0431
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0034 0.0199 0.0199
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0033 0.0188 0.0188
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0065 0.0479 0.0459
Loa Loa (eye worm) cyclin domain-containing protein 0.0278 0.2434 0.2407
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0023 0.0092 0.0056
Entamoeba histolytica cell division protein kinase 2, putative 0.005 0.0341 0.2265
Plasmodium vivax methionine aminopeptidase 1a, putative 0.0022 0.0085 0.0038
Brugia malayi hypothetical protein 0.0023 0.0092 0.0056
Onchocerca volvulus 0.0023 0.0092 0.0139
Leishmania major inosine-5-monophosphate dehydrogenase 0.1103 1 1
Brugia malayi Death domain containing protein 0.0017 0.0036 0.000000022145
Loa Loa (eye worm) hypothetical protein 0.0017 0.0037 0.0001
Onchocerca volvulus 0.0024 0.0104 0.0167
Mycobacterium ulcerans inosine 5-monophosphate dehydrogenase 0.1038 0.9399 0.9396
Loa Loa (eye worm) hypothetical protein 0.0019 0.0056 0.002
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0034 0.0199 0.0199
Schistosoma mansoni chloride channel protein 0.0066 0.0485 0.0485
Echinococcus granulosus c src tyrosine kinase 0.0034 0.0199 0.0199
Echinococcus multilocularis cyclin B 0.0069 0.0513 0.0513
Schistosoma mansoni peptidase 0.0022 0.0085 0.0085
Toxoplasma gondii IMP dehydrogenas 0.1103 1 1
Mycobacterium tuberculosis Conserved protein 0.0066 0.0485 0.0403
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0036 0.0209 0.0174
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0036 0.0209 0.0174
Onchocerca volvulus 0.0023 0.0092 0.0139
Trichomonas vaginalis cyclins, putative 0.004 0.0254 0.0732
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0034 0.0199 0.0199
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0023 0.0092 0.0092
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MG, Family M24 0.0022 0.0085 0.0035
Brugia malayi SH2 domain containing protein 0.0023 0.0092 0.0056
Toxoplasma gondii methionine aminopeptidase 2, putative 0.0177 0.1505 0.1462
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0017 0.0037 0.0037
Loa Loa (eye worm) hypothetical protein 0.0036 0.0209 0.0174
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0036 0.0209 0.0428
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0036 0.0209 0.0174
Schistosoma mansoni hypothetical protein 0.0104 0.0836 0.0836
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0017 0.0036 0.0036
Mycobacterium tuberculosis Conserved protein 0.0066 0.0485 0.0403
Trypanosoma cruzi aminopeptidase P, putative 0.0022 0.0085 0.0035
Schistosoma mansoni growth factor receptor-bound protein 0.0173 0.1471 0.1471
Trichomonas vaginalis cyclin D, putative 0.004 0.0254 0.0732
Entamoeba histolytica protein kinase domain containing protein 0.0065 0.0479 0.3184
Echinococcus granulosus expressed conserved protein 0.0023 0.0092 0.0092
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0036 0.0209 0.0174
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0023 0.0092 0.0092
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0019 0.0056 0.0056
Brugia malayi Uncoordinated protein 44 0.0017 0.0036 0.000000022145
Onchocerca volvulus 0.0274 0.2393 0.5818
Echinococcus multilocularis 5' AMP activated protein kinase subunit gamma 0.0066 0.0485 0.0485
Echinococcus multilocularis H(+):Cl() exchange transporter 7 0.0066 0.0485 0.0485
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0036 0.0209 0.0209
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0019 0.0056 0.0056
Schistosoma mansoni suppressor of cytokine signaling 0.0023 0.0092 0.0092
Schistosoma mansoni tyrosine kinase 0.0034 0.0199 0.0199
Chlamydia trachomatis GutQ/KpsF family sugar-phosphate isomerase 0.0066 0.0485 1
Echinococcus granulosus tyrosine kinase 0.0024 0.0104 0.0104
Schistosoma mansoni AMP-activated protein kinase gamma regulatory subunit 0.0066 0.0485 0.0485
Loa Loa (eye worm) hypothetical protein 0.0058 0.0412 0.0377
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0177 0.1505 0.6155
Echinococcus multilocularis cyclin B3 1 0.004 0.0254 0.0254
Leishmania major methionine aminopeptidase, putative,metallo-peptidase, Clan MG, Family M24 0.0022 0.0085 0.0035
Loa Loa (eye worm) hypothetical protein 0.0023 0.0092 0.0056
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0065 0.0479 0.0479
Leishmania major aminopeptidase P, putative,metallo-peptidase, Clan MG, Family M24 0.0022 0.0085 0.0035
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0024 0.0104 0.0104
Loa Loa (eye worm) SH2 domain-containing protein 0.0023 0.0092 0.0056
Giardia lamblia Hypothetical protein 0.0066 0.0485 0.2813
Trypanosoma brucei AMP-activated protein kinase, gamma regulatory subunit 0.0066 0.0485 0.0437
Echinococcus granulosus cyclins 0.004 0.0254 0.0254
Echinococcus multilocularis SNF4:AMP activated protein kinase gamma subunit 0.0066 0.0485 0.0485
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.005 0.0341 0.0292
Brugia malayi cell division control protein 2 homolog 0.005 0.0341 0.0306
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0017 0.0037 0.0003
Schistosoma mansoni serine/threonine protein kinase 0.0106 0.0859 0.0859
Schistosoma mansoni hypothetical protein 0.0056 0.0394 0.0394
Brugia malayi inosine-5'-monophosphate dehydrogenase 0.0459 0.4088 0.4066
Schistosoma mansoni nuclear receptor 0.0017 0.0037 0.0037
Brugia malayi SH2 domain containing protein 0.0023 0.0092 0.0056
Schistosoma mansoni hypothetical protein 0.0018 0.0051 0.0051
Onchocerca volvulus Methionine aminopeptidase 2 homolog 0.0177 0.1505 0.3625
Trichomonas vaginalis AGC family protein kinase 0.0065 0.0479 0.1708
Schistosoma mansoni signal transduction protein lnk-related 0.0023 0.0092 0.0092
Schistosoma mansoni nuclear hormone receptor 0.0017 0.0037 0.0037
Plasmodium falciparum methionine aminopeptidase 1c, putative 0.0022 0.0085 0.0038
Echinococcus multilocularis H(+):Cl() exchange transporter 3 0.0066 0.0485 0.0485
Loa Loa (eye worm) TK/FER protein kinase 0.0024 0.0104 0.0068
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0036 0.0209 0.0209
Echinococcus granulosus cyclin dependent kinase 1 0.005 0.0341 0.0341
Brugia malayi nuclear receptor NHR-67 0.0017 0.0037 0.0001
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0034 0.0199 0.0199
Echinococcus granulosus methionine aminopeptidase type I 0.0022 0.0085 0.0085
Loa Loa (eye worm) hypothetical protein 0.0034 0.02 0.0164
Brugia malayi Cyclin, N-terminal domain containing protein 0.0278 0.2434 0.2407
Trichomonas vaginalis set domain proteins, putative 0.0274 0.2392 1
Schistosoma mansoni tensin-related 0.0031 0.0172 0.0172
Schistosoma mansoni jumonji/arid domain-containing protein 0.0068 0.0507 0.0507
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.02 0.02
Brugia malayi metallopeptidase family M24 containing protein 0.0022 0.0085 0.0049
Plasmodium falciparum serine/threonine protein kinase, putative 0.0065 0.0479 0.0459
Brugia malayi SRC-1 0.0034 0.0199 0.0163
Giardia lamblia Aurora kinase 0.0065 0.0479 0.2776
Brugia malayi cytokine inducible SH2-containing protein 5 0.0023 0.0092 0.0056
Schistosoma mansoni tyrosine kinase 0.0034 0.0199 0.0199
Loa Loa (eye worm) hypothetical protein 0.0018 0.005 0.0014
Loa Loa (eye worm) hypothetical protein 0.0025 0.0114 0.0078
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0018 0.005 0.005
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0036 0.0209 0.0209
Echinococcus multilocularis inosine 5' monophosphate dehydrogenase 2 0.1103 1 1
Loa Loa (eye worm) TK/ABL protein kinase 0.0024 0.0104 0.0068
Schistosoma mansoni cyclins 0.004 0.0254 0.0254
Echinococcus multilocularis ecdysone induced protein 78C 0.0036 0.0209 0.0209
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0159 0.1345 0.1314
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0036 0.0209 0.0209
Brugia malayi hypothetical protein 0.0017 0.0037 0.0001
Schistosoma mansoni nck2/grb4 0.0033 0.0187 0.0187
Brugia malayi Calcitonin receptor-like protein seb-1 0.0058 0.0412 0.0377
Toxoplasma gondii creatinase domain-containing protein 0.0022 0.0085 0.0035
Plasmodium vivax protein kinase Crk2 0.005 0.0341 0.0311
Loa Loa (eye worm) hypothetical protein 0.0049 0.0329 0.0294
Trypanosoma cruzi metallo-peptidase, Clan MG, Family M24 0.0177 0.1505 0.1462
Toxoplasma gondii methionine aminopeptidase, type i, putative 0.0022 0.0085 0.0035
Trichomonas vaginalis cyclin B, putative 0.0069 0.0513 0.1854
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0034 0.0199 0.0199
Echinococcus granulosus nuclear factor of activated T cells 5 0.0085 0.0664 0.0664
Plasmodium falciparum protein kinase 5 0.005 0.0341 0.0311
Brugia malayi serine/threonine kinase 12 0.0065 0.0479 0.0445
Echinococcus granulosus tensin 0.0023 0.0092 0.0092
Mycobacterium tuberculosis Probable conserved transmembrane alanine and leucine rich protein 0.0066 0.0485 0.0403
Onchocerca volvulus Dipeptidase C homolog 0.0022 0.0085 0.0121
Loa Loa (eye worm) AUR protein kinase 0.0065 0.0479 0.0445
Brugia malayi nuclear hormone receptor 0.0036 0.0209 0.0174
Toxoplasma gondii CBS domain-containing protein 0.0066 0.0485 0.0437
Onchocerca volvulus 0.0024 0.0104 0.0167
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0017 0.0037 0.0001
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0071 0.0532 0.0483
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0177 0.1505 0.6155
Loa Loa (eye worm) hypothetical protein 0.0017 0.0037 0.0001
Echinococcus granulosus H:Cl exchange transporter 7 0.0066 0.0485 0.0485
Brugia malayi Methionine aminopeptidase protein type I 0.0022 0.0085 0.0049
Echinococcus multilocularis cyclins 0.004 0.0254 0.0254
Brugia malayi Voltage gated chloride channel family protein 0.0066 0.0485 0.045
Echinococcus granulosus methionyl aminopeptidase 2 0.0177 0.1505 0.1505
Echinococcus granulosus inosine 5' monophosphate dehydrogenase 2 0.1103 1 1
Giardia lamblia Kinase, CMGC CDK 0.005 0.0341 0.1801
Echinococcus multilocularis c src tyrosine kinase 0.0034 0.0199 0.0199
Loa Loa (eye worm) hypothetical protein 0.0017 0.0037 0.0001
Schistosoma mansoni hypothetical protein 0.0072 0.0546 0.0546
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0019 0.0056 0.002
Trichomonas vaginalis cyclin D, putative 0.004 0.0254 0.0732
Trypanosoma brucei metallo-peptidase, Clan MG, Family M24 0.0177 0.1505 0.1462
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.005 0.0341 0.0292
Schistosoma mansoni serine/threonine protein kinase 0.005 0.0341 0.0341
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.005 0.0341 0.0306
Mycobacterium tuberculosis Probable inosine-5'-monophosphate dehydrogenase GuaB3 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase 0.0579 0.5195 0.5154
Entamoeba histolytica protein kinase , putative 0.0065 0.0479 0.3184
Leishmania major hypothetical protein, conserved 0.0066 0.0485 0.0437
Mycobacterium ulcerans aminopeptidase 0.0022 0.0085 0.0034
Echinococcus multilocularis signal transduction protein lnk realted 0.0023 0.0092 0.0092
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0036 0.0209 0.0209
Brugia malayi ancient conserved domain protein 4 0.0066 0.0485 0.045
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0159 0.1345 0.1345
Plasmodium falciparum aminopeptidase P 0.0022 0.0085 0.0038
Loa Loa (eye worm) hypothetical protein 0.0017 0.0037 0.0001
Echinococcus multilocularis lamin dm0 0.0054 0.038 0.038
Trypanosoma cruzi AMP-activated protein kinase, gamma regulatory subunit 0.0066 0.0485 0.0437
Echinococcus multilocularis Xaa Pro aminopeptidase 3 0.0022 0.0085 0.0085
Brugia malayi hypothetical protein 0.0072 0.0546 0.0512
Loa Loa (eye worm) hypothetical protein 0.0023 0.0092 0.0056
Brugia malayi metallopeptidase family M24 containing protein 0.0022 0.0085 0.0049
Brugia malayi GMP reductase 0.0459 0.4088 0.4066
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0036 0.0209 0.0174
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.0065 0.0479 0.3184
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0018 0.005 0.005
Loa Loa (eye worm) hypothetical protein 0.0036 0.0209 0.0174
Schistosoma mansoni hypothetical protein 0.0017 0.0036 0.0036
Echinococcus granulosus G protein coupled receptor kinase 1 0.0095 0.0759 0.0759
Loa Loa (eye worm) intermediate filament protein 0.0054 0.038 0.0346
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0062 0.045 0.0416
Schistosoma mansoni netrin receptor unc5 0.0017 0.0036 0.0036
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0159 0.1345 0.1314
Echinococcus granulosus jumonji domain containing 1A 0.0018 0.005 0.005
Trichomonas vaginalis cyclins, putative 0.0038 0.0232 0.0637
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0034 0.0199 0.0199
Entamoeba histolytica hypothetical protein 0.0072 0.0546 0.3629
Schistosoma mansoni lamin 0.0054 0.038 0.038
Echinococcus granulosus GPCR family 2 0.0018 0.0051 0.0051
Brugia malayi protein-tyrosine kinase 0.0024 0.0104 0.0068
Loa Loa (eye worm) hypothetical protein 0.0022 0.0085 0.0049
Echinococcus granulosus NCK adaptor protein 0.0033 0.0187 0.0187
Onchocerca volvulus 0.0054 0.038 0.085
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0036 0.0209 0.0209
Plasmodium falciparum protein MAM3, putative 0.0066 0.0485 0.0465
Trypanosoma cruzi metallo- peptidase, Clan MG, Family M24 0.0022 0.0085 0.0035
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0036 0.0209 0.0174
Schistosoma mansoni GTPase activating protein 0.0023 0.0092 0.0092
Giardia lamblia Hypothetical protein 0.004 0.0254 0.1189
Loa Loa (eye worm) TK protein kinase 0.0024 0.0104 0.0068
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0036 0.0209 0.0209
Loa Loa (eye worm) AUR protein kinase 0.0065 0.0479 0.0445

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.004 nM Inhibition of binding to Growth factor receptor bound protein 2 (Grb2) SH2 domain ChEMBL. 9599224
IC50 (binding) = 0.97 nM Inhibition of binding to N-terminal p85 SH2 domain ChEMBL. 9599224
IC50 (binding) = 1 nM Inhibition of binding to Grb2 SH2 domain ChEMBL. 9599224
IC50 (binding) > 5 nM Inhibition of interaction between the activated tyrosine kinase receptors and Shp2 SH2 domains in the Ras signal transduction pathway. ChEMBL. 9599224
IC50 (binding) > 5 nM Inhibition of binding to SH2 domain of SHC-PTB ChEMBL. 9599224
IC50 (binding) = 6.24 nM Inhibition of binding to p56 Lck tyrosine kinase SH2 domain ChEMBL. 9599224

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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