Detailed information for compound 705606

Basic information

Technical information
  • TDR Targets ID: 705606
  • Name: N-(3-fluorophenyl)-N',N'-dimethyl-1-phenylpyr azolo[4,5-e]pyrimidine-4,6-diamine
  • MW: 348.377 | Formula: C19H17FN6
  • H donors: 1 H acceptors: 3 LogP: 4.28 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Fc1cccc(c1)Nc1nc(nc2c1cnn2c1ccccc1)N(C)C
  • InChi: 1S/C19H17FN6/c1-25(2)19-23-17(22-14-8-6-7-13(20)11-14)16-12-21-26(18(16)24-19)15-9-4-3-5-10-15/h3-12H,1-2H3,(H,22,23,24)
  • InChiKey: ZWOPASNGYPFNTE-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(3-fluorophenyl)-N',N'-dimethyl-1-phenyl-pyrazolo[4,5-e]pyrimidine-4,6-diamine
  • (6-dimethylamino-1-phenyl-pyrazolo[4,5-e]pyrimidin-4-yl)-(3-fluorophenyl)amine

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0068 0.0655 0.5382
Echinococcus granulosus solute carrier family 22 0.0031 0.0257 0.1119
Trypanosoma brucei metacaspase 5, putative 0.0019 0.0127 0.1025
Echinococcus multilocularis Smad4 0.0008 0.0014 0.0063
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0096 0.0953 0.4151
Schistosoma mansoni 6-phosphofructokinase 0.012 0.1215 0.529
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0061 0.0477
Leishmania major histidyl-tRNA synthetase, putative 0.0007 0.0004 0.0003
Trypanosoma cruzi sugar transporter, putative 0.0031 0.0257 0.2095
Toxoplasma gondii aldehyde dehydrogenase 0.0061 0.0576 0.0864
Echinococcus multilocularis solute carrier family 22 0.0031 0.0257 0.1119
Onchocerca volvulus Cell death protein 3 homolog 0.0063 0.0602 1
Schistosoma mansoni hypothetical protein 0.0015 0.0088 0.0383
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0257 0.1107
Giardia lamblia Glycyl-tRNA synthetase 0.0012 0.0057 0.0849
Trichomonas vaginalis phosphofructokinase, putative 0.012 0.1215 0.5283
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0327 0.141
Mycobacterium leprae Probable lipase LipE 0.0038 0.0327 0.2431
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0125 0.1934
Plasmodium falciparum calcium-dependent protein kinase 4 0.0068 0.0656 0.0653
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0013 0.0061 0.0477
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.0578 0.2517
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0125 0.0342
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0084 0.0829 0.3205
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0257 0.1107
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0357 0.3763 0.3761
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0019 0.0127 0.0542
Leishmania major lysyl-tRNA synthetase, putative 0.0049 0.0453 0.3713
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.012 0.1215 0.4774
Trichomonas vaginalis mercuric reductase, putative 0.0013 0.0061 0.0252
Chlamydia trachomatis threonine--tRNA ligase 0.0012 0.0057 0.1193
Trypanosoma cruzi glycyl-tRNA synthetase, putative 0.0007 0.0004 0.0003
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0127 0.0542
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0257 0.1107
Loa Loa (eye worm) major facilitator superfamily transporter 0.0031 0.0257 0.1107
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0009 0.0024 0.0093
Brugia malayi major facilitator superfamily protein 0.0031 0.0257 0.1107
Loa Loa (eye worm) hypothetical protein 0.0038 0.0327 0.141
Echinococcus multilocularis musashi 0.0027 0.0213 0.0928
Mycobacterium tuberculosis Probable esterase LipL 0.0038 0.0327 0.116
Plasmodium vivax proline--tRNA ligase, putative 0.0077 0.0753 0.075
Loa Loa (eye worm) MH1 domain-containing protein 0.0008 0.0014 0.0049
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0031 0.0257 0.0254
Brugia malayi MH1 domain containing protein 0.0008 0.0014 0.0049
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0015 0.0088 0.0383
Trypanosoma cruzi metacaspase 5, putative 0.0019 0.0127 0.1025
Echinococcus multilocularis lamin dm0 0.0027 0.0213 0.0928
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0066 0.0635 0.2766
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0257 0.1107
Schistosoma mansoni aspartyl-tRNA synthetase 0.0007 0.0003 0.0014
Trypanosoma brucei glucose transporter, putative 0.0069 0.0659 0.5415
Onchocerca volvulus 0.0031 0.0257 0.1127
Trypanosoma brucei glycyl-tRNA synthetase, putative 0.0012 0.0057 0.0443
Schistosoma mansoni intermediate filament proteins 0.0027 0.0213 0.0928
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0013 0.0061 0.2275
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0019 0.0127 0.0555
Toxoplasma gondii histidyl-tRNA synthetase (HisRS), putative 0.0007 0.0004 0.0001
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0257 0.1107
Schistosoma mansoni smad1 5 8 and 0.0008 0.0014 0.0063
Giardia lamblia NADH oxidase lateral transfer candidate 0.0013 0.0061 0.0914
Echinococcus granulosus smad 0.0008 0.0014 0.0063
Echinococcus multilocularis mothers against decapentaplegic 5 0.0008 0.0014 0.0063
Loa Loa (eye worm) hypothetical protein 0.0031 0.0257 0.1107
Schistosoma mansoni cpg binding protein 0.0029 0.0232 0.101
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0077 0.0753 0.6191
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0068 0.0655 0.2854
Onchocerca volvulus 0.0031 0.0257 0.1127
Toxoplasma gondii lysine-tRNA ligase 0.0049 0.0453 0.0678
Plasmodium vivax glutathione reductase, putative 0.0037 0.032 0.0317
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0257 0.1107
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0049 0.0453 0.1962
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0013 0.0061 0.0252
Trypanosoma cruzi metacaspase, putative 0.0019 0.0127 0.1025
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0257 0.1107
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0257 0.1107
Onchocerca volvulus 0.0031 0.0257 0.1127
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0125 0.0533
Brugia malayi glutathione reductase 0.0037 0.032 0.1383
Trypanosoma brucei glucose transporter, putative 0.0069 0.0659 0.5415
Loa Loa (eye worm) glutathione reductase 0.0037 0.032 0.1383
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0357 0.3763 0.5671
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0059 0.0556 0.4565
Echinococcus multilocularis calcium dependent protein kinase 0.0063 0.0605 0.2635
Loa Loa (eye worm) hypothetical protein 0.0013 0.0058 0.0239
Schistosoma mansoni glucose transport protein 0.0221 0.2296 1
Trichomonas vaginalis CMGC family protein kinase 0.0059 0.0556 0.2412
Echinococcus granulosus mitogen activated protein kinase 0.0059 0.0556 0.2423
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0066 0.0635 0.5217
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0013 0.0061 0.0477
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0257 0.1107
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0576 0.2507
Toxoplasma gondii glycyl-tRNA synthetase 0.0012 0.0057 0.0081
Loa Loa (eye worm) 6-phosphofructokinase 0.012 0.1215 0.5283
Chlamydia trachomatis histidine--tRNA ligase 0.0007 0.0004 0.0008
Schistosoma mansoni protein kinase 0.0068 0.0655 0.2854
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0257 0.1107
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.0031 0.0257 0.0878
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.004 0.0351 0.1528
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0032 0.0272 0.4257
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0041 0.0166
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0576 0.2507
Schistosoma mansoni lamin 0.0027 0.0213 0.0928
Loa Loa (eye worm) hypothetical protein 0.0044 0.0398 0.1724
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0084 0.0829 0.3205
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0061 0.0477
Trypanosoma cruzi hypothetical protein, conserved 0.0011 0.0041 0.0315
Trypanosoma cruzi histidyl-tRNA synthetase 0.0007 0.0004 0.0003
Trichomonas vaginalis sugar transporter, putative 0.0069 0.0659 0.2861
Echinococcus multilocularis lysyl tRNA synthetase 0.0049 0.0453 0.1973
Echinococcus granulosus histidyl tRNA synthetase 0.0007 0.0004 0.0015
Plasmodium falciparum glutathione reductase 0.0037 0.032 0.0317
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0059 0.0556 0.4565
Brugia malayi Latrophilin receptor protein 2 0.0015 0.0088 0.0369
Trichomonas vaginalis conserved hypothetical protein 0.0069 0.0659 0.2861
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0013 0.0061 0.0477
Onchocerca volvulus 0.0031 0.0257 0.1127
Trypanosoma brucei Aminoacyl-tRNA editing domain containing protein, putative 0.0011 0.0041 0.0315
Echinococcus multilocularis smad 0.0008 0.0014 0.0063
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0049 0.0453 0.3713
Loa Loa (eye worm) hypothetical protein 0.0038 0.0327 0.141
Loa Loa (eye worm) glycyl-tRNA synthetase 0.0012 0.0057 0.0234
Mycobacterium ulcerans threonyl-tRNA synthetase 0.0012 0.0057 0.0443
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0576 0.4726
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0059 0.0556 0.2412
Schistosoma mansoni glucose transporter 0.0031 0.0257 0.1119
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0013 0.0061 0.0477
Brugia malayi hypothetical protein 0.0031 0.0257 0.1107
Toxoplasma gondii transporter, major facilitator family protein 0.0031 0.0257 0.0383
Brugia malayi Sugar transporter family protein 0.0031 0.0257 0.1107
Echinococcus multilocularis caspase 2 0.0063 0.0602 0.2624
Plasmodium vivax 6-phosphofructokinase, putative 0.0032 0.0272 0.0269
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0257 0.1107
Brugia malayi Calcitonin receptor-like protein seb-1 0.0048 0.0443 0.1919
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0042 0.0373 0.135
Loa Loa (eye worm) Smad1 0.0008 0.0014 0.0049
Brugia malayi major facilitator superfamily protein 0.0031 0.0257 0.1107
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0068 0.0655 0.2844
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0213 0.0916
Onchocerca volvulus 0.0031 0.0257 0.1127
Mycobacterium tuberculosis Conserved protein 0.0038 0.0327 0.116
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0077 0.0753 0.6191
Echinococcus granulosus asparaginyl tRNA synthetase cytoplasmic 0.0007 0.0003 0.0014
Trypanosoma cruzi Aminoacyl-tRNA editing domain containing protein, putative 0.0011 0.0041 0.0315
Echinococcus multilocularis asparaginyl tRNA synthetase, cytoplasmic 0.0007 0.0003 0.0014
Entamoeba histolytica hypothetical protein 0.004 0.0351 0.2869
Trypanosoma cruzi metacaspase, putative 0.0019 0.0127 0.1025
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0127 0.0542
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0032 0.0272 0.5981
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0013 0.0061 0.0477
Plasmodium vivax hexose transporter 0.0221 0.2296 0.2294
Giardia lamblia Kinase, CMGC MAPK 0.0059 0.0556 0.8751
Schistosoma mansoni ap endonuclease 0.0019 0.0125 0.0546
Plasmodium vivax CDK-related protein kinase 6, putative 0.0938 1 1
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0061 0.0576 0.4726
Loa Loa (eye worm) hypothetical protein 0.0031 0.0257 0.1107
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0221 0.2296 1
Schistosoma mansoni transcription factor LCR-F1 0.004 0.0351 0.1528
Trypanosoma brucei sugar transporter, putative 0.0031 0.0257 0.2095
Echinococcus granulosus thioredoxin glutathione reductase 0.0037 0.0326 0.1418
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0221 0.2296 1
Loa Loa (eye worm) hypothetical protein 0.0013 0.0058 0.0239
Echinococcus granulosus lysyl tRNA synthetase 0.0049 0.0453 0.1973
Mycobacterium tuberculosis Probable lipase LipD 0.0038 0.0327 0.116
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0031 0.0257 0.2095
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0327 0.2669
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0257 0.1107
Mycobacterium tuberculosis Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase)(ThrRS) (threonine-tRNA ligase) 0.0012 0.0057 0.0063
Mycobacterium ulcerans esterase/lipase LipP 0.0038 0.0327 0.2669
Loa Loa (eye worm) hypothetical protein 0.0031 0.0257 0.1107
Plasmodium falciparum calcium-dependent protein kinase 2 0.0068 0.0656 0.0653
Loa Loa (eye worm) hypothetical protein 0.0031 0.0257 0.1107
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0013 0.0061 0.1284
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0125 0.0533
Trypanosoma brucei glucose transporter, putative 0.0069 0.0659 0.5415
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0077 0.0753 0.1131
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0019 0.0127 0.0542
Trypanosoma cruzi hexose transporter, putative 0.0069 0.0659 0.5415
Leishmania major hypothetical protein, conserved 0.0011 0.0041 0.0315
Loa Loa (eye worm) threonyl-tRNA synthetase 0.0012 0.0057 0.0234
Echinococcus granulosus glycyl tRNA synthetase 0.0012 0.0057 0.0248
Onchocerca volvulus 0.0031 0.0257 0.1127
Giardia lamblia Hexose transporter 0.0031 0.0257 0.4016
Trichomonas vaginalis glucose transporter, putative 0.0031 0.0257 0.1107
Trypanosoma brucei glucose transporter 2A 0.0069 0.0659 0.5415
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0257 0.1107
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0125 0.0546
Plasmodium falciparum lysine--tRNA ligase 0.0049 0.0453 0.045
Loa Loa (eye worm) hypothetical protein 0.0031 0.0257 0.1107
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0038 0.0327 0.116
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0059 0.0556 0.4565
Leishmania major metacaspase, putative 0.0019 0.0127 0.1025
Schistosoma mansoni threonyl-tRNA synthetase 0.0007 0.0004 0.0015
Schistosoma mansoni serine/threonine protein kinase 0.0068 0.0655 0.2854
Trichomonas vaginalis sugar transporter, putative 0.0069 0.0659 0.2861
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0019 0.0127 0.0542
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0257 0.1107
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0257 0.1107
Entamoeba histolytica threonyl-tRNA synthetase, putative 0.0012 0.0057 0.0443
Trichomonas vaginalis sugar transport protein, putative 0.0031 0.0257 0.1107
Plasmodium vivax hypothetical protein, conserved 0.0038 0.0327 0.0323
Loa Loa (eye worm) sugar transporter 0.0221 0.2296 1
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0221 0.2296 1
Schistosoma mansoni smad1 5 8 and 0.0008 0.0014 0.0063
Trypanosoma brucei glucose transporter 1E 0.0069 0.0659 0.5415
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0125 0.0533
Mycobacterium ulcerans beta-lactamase 0.0038 0.0327 0.2669
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0576 0.4726
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0257 0.1107
Plasmodium falciparum thioredoxin reductase 0.0013 0.0061 0.0058
Mycobacterium tuberculosis Probable hydrolase 0.0038 0.0327 0.116
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0257 0.1107
Loa Loa (eye worm) hypothetical protein 0.0066 0.0635 0.2756
Loa Loa (eye worm) hypothetical protein 0.0015 0.0088 0.0369
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0008 0.0014 0.0063
Plasmodium falciparum thioredoxin reductase 0.0037 0.032 0.0317
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0068 0.0655 0.2854
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0042 0.0373 0.135
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0013 0.0061 0.0265
Schistosoma mansoni glucose transport protein 0.0221 0.2296 1
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0094 0.093 0.7575
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0272 0.1173
Schistosoma mansoni aspartyl-tRNA synthetase 0.0007 0.0003 0.0014
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0019 0.0127 0.0542
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0019 0.0127 0.0555
Trypanosoma cruzi hexose transporter, putative 0.0069 0.0659 0.5415
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0125 0.1009
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0096 0.0953 0.4151
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0257 0.1107
Onchocerca volvulus 0.0031 0.0257 0.1127
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0257 0.1107
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0327 0.141
Brugia malayi Cam kinase protein 1 0.0068 0.0655 0.2844
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0221 0.2296 1
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0257 0.1107
Leishmania major hypothetical protein, conserved 0.0031 0.0257 0.2095
Echinococcus multilocularis mitogen activated protein kinase 0.0059 0.0556 0.2423
Treponema pallidum threonyl-tRNA synthetase 0.0012 0.0057 0.0443
Onchocerca volvulus 0.0038 0.0327 0.2912
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0019 0.0127 0.0187
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0038 0.0327 0.116
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0043 0.0388 0.1677
Echinococcus multilocularis histidyl tRNA synthetase 0.0007 0.0004 0.0015
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0257 0.1107
Trichomonas vaginalis phosphofructokinase, putative 0.012 0.1215 0.5283
Echinococcus multilocularis GPCR, family 2 0.0015 0.0088 0.0383
Echinococcus multilocularis cpg binding protein 0.003 0.025 0.1087
Leishmania major hypothetical protein, conserved 0.0038 0.0327 0.2669
Onchocerca volvulus Putative transporter 0.0031 0.0257 0.1127
Schistosoma mansoni glucose transport protein 0.0221 0.2296 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0015 0.0088 0.0383
Giardia lamblia Sugar-proton symporter 0.0031 0.0257 0.4016
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0049 0.0453 0.3713
Onchocerca volvulus 0.0031 0.0257 0.1127
Brugia malayi hypothetical protein 0.0031 0.0257 0.1107
Echinococcus granulosus cpg binding protein 0.003 0.025 0.1087
Loa Loa (eye worm) hypothetical protein 0.0031 0.0257 0.1107
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0213 0.0916
Toxoplasma gondii 6-phosphofructokinase 0.0032 0.0272 0.0406
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0221 0.2296 1
Brugia malayi Sugar transporter family protein 0.0221 0.2296 1
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0094 0.093 0.3616
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.012 0.1215 1
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0032 0.0272 0.2221
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0257 0.1107
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0125 0.1009
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0013 0.0061 0.008
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0013 0.0061 0.0477
Echinococcus granulosus mothers against decapentaplegic 5 0.0008 0.0014 0.0063
Brugia malayi Major Facilitator Superfamily protein 0.0031 0.0257 0.1107
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0019 0.0127 0.0542
Schistosoma mansoni caspase-7 (C14 family) 0.0019 0.0127 0.0555
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0257 0.1107
Loa Loa (eye worm) hypothetical protein 0.0031 0.0257 0.1107
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0257 0.1107
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.012 0.1215 1
Trypanosoma cruzi hexose transporter, putative 0.0069 0.0659 0.5415
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0019 0.0127 0.0555
Schistosoma mansoni aspartyl-tRNA synthetase 0.0007 0.0003 0.0014
Schistosoma mansoni hypothetical protein 0.004 0.0351 0.1528
Schistosoma mansoni hypothetical protein 0.0015 0.0088 0.0383
Loa Loa (eye worm) latrophilin receptor protein 2 0.0015 0.0088 0.0369
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0127 0.0542
Echinococcus multilocularis asparaginyl tRNA synthetase, cytoplasmic 0.0007 0.0003 0.0014
Trypanosoma brucei glucose transporter, putative 0.0069 0.0659 0.5415
Loa Loa (eye worm) thioredoxin reductase 0.0037 0.032 0.1383
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0066 0.0635 0.5062
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0066 0.0635 0.2756
Echinococcus multilocularis apoptotic protease activating factor 1 0.0044 0.0398 0.1735
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0257 0.1107
Brugia malayi hypothetical protein 0.0031 0.0257 0.1107
Echinococcus granulosus mitogen activated protein kinase 3 0.0059 0.0556 0.2423
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0257 0.1107
Trichomonas vaginalis conserved hypothetical protein 0.0069 0.0659 0.2861
Treponema pallidum NADH oxidase 0.0013 0.0061 0.0477
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0013 0.0061 0.2275
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0257 0.1107
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0068 0.0655 0.2854
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0068 0.0655 0.2844
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0125 0.0546
Entamoeba histolytica histidyl-tRNA synthetase, putative 0.0007 0.0004 0.0003
Plasmodium falciparum calcium-dependent protein kinase 5 0.0068 0.0656 0.0653
Leishmania major glucose transporter, lmgt2 0.0069 0.0659 0.5415
Plasmodium vivax 6-phosphofructokinase, putative 0.0032 0.0272 0.0269
Echinococcus granulosus Sugar transporter ERD6 protein 0.0031 0.0257 0.1119
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0079 0.0329
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0257 0.1107
Brugia malayi Major Facilitator Superfamily protein 0.0031 0.0257 0.1107
Entamoeba histolytica protein kinase, putative 0.0068 0.0655 0.5382
Plasmodium vivax calcium-dependent protein kinase, putative 0.0068 0.0656 0.0653
Treponema pallidum prolyl-tRNA synthetase 0.0023 0.0175 0.1417
Schistosoma mansoni protein kinase 0.0068 0.0655 0.2854
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0327 0.2669
Mycobacterium leprae conserved hypothetical protein 0.0038 0.0327 0.2431
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0013 0.0061 0.0058
Brugia malayi glycyl-tRNA synthetase 0.0012 0.0057 0.0234
Echinococcus multilocularis caspase 8 0.0019 0.0127 0.0555
Trypanosoma cruzi trypanothione reductase, putative 0.0013 0.0061 0.0477
Echinococcus granulosus beta LACTamase domain containing family member 0.0038 0.0327 0.1422
Brugia malayi lysyl-tRNA synthetase 0.0049 0.0453 0.1962
Plasmodium vivax thioredoxin reductase, putative 0.0037 0.032 0.0317
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0257 0.1107
Brugia malayi CXXC zinc finger family protein 0.0029 0.0232 0.0998
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0015 0.0088 0.0383
Brugia malayi 6-phosphofructokinase 0.012 0.1215 0.5283
Loa Loa (eye worm) 6-phosphofructokinase 0.012 0.1215 0.5283
Loa Loa (eye worm) hypothetical protein 0.0068 0.0655 0.2844
Loa Loa (eye worm) hypothetical protein 0.0033 0.0279 0.1202
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0059 0.0556 0.4565
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0049 0.0453 0.3713
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0068 0.0656 0.0984
Loa Loa (eye worm) hypothetical protein 0.0066 0.0635 0.2756
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0027 0.0216 0.0926
Giardia lamblia Lysyl-tRNA synthetase 0.0049 0.0453 0.7117
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0096 0.0953 0.4151
Entamoeba histolytica hypothetical protein 0.0049 0.0453 0.3713
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0068 0.0656 0.0984
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0127 0.0542
Schistosoma mansoni sugar transporter 0.0031 0.0257 0.1119
Mycobacterium ulcerans integral membrane transport protein 0.0031 0.0257 0.2095
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0013 0.0061 0.0058
Onchocerca volvulus 0.0038 0.0327 0.2912
Trichomonas vaginalis glycyl-tRNA synthetase, putative 0.0007 0.0004 0.0002
Mycobacterium ulcerans prolyl-tRNA synthetase 0.0023 0.0175 0.1417
Echinococcus granulosus GPCR family 2 0.0015 0.0088 0.0383
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0125 0.1009
Onchocerca volvulus 0.0044 0.0398 0.4759
Toxoplasma gondii ABC1 family protein 0.0038 0.0327 0.0488
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0257 0.1107
Trypanosoma cruzi hexose transporter, putative 0.0037 0.0326 0.2661
Trypanosoma brucei threonyl-tRNA synthetase, putative 0.0012 0.0057 0.0443
Loa Loa (eye worm) hypothetical protein 0.0038 0.0327 0.141
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0068 0.0655 0.2854
Mycobacterium ulcerans sugar transporter 0.0031 0.0257 0.2095
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0257 0.1107
Trichomonas vaginalis phosphofructokinase, putative 0.012 0.1215 0.5283
Chlamydia trachomatis proline--tRNA ligase 0.0023 0.0175 0.3815
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0068 0.0656 0.0984
Leishmania major trypanothione reductase 0.0037 0.032 0.2618
Trypanosoma cruzi metacaspase, putative 0.0019 0.0127 0.1025
Loa Loa (eye worm) hypothetical protein 0.0049 0.0453 0.1962
Trypanosoma cruzi metacaspase, putative 0.0019 0.0127 0.1025
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0031 0.0257 0.1119
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0013 0.0061 0.0477
Trypanosoma brucei glucose transporter, putative 0.0069 0.0659 0.5415
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0038 0.0327 0.116
Echinococcus granulosus caspase 0.0019 0.0127 0.0555
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0079 0.0329
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0013 0.0061 0.0265
Loa Loa (eye worm) hypothetical protein 0.0031 0.0257 0.1107
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.012 0.1215 1
Trypanosoma brucei glucose transporter, putative 0.0069 0.0659 0.5415
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0221 0.2296 1
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0327 0.141
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0066 0.0635 0.2756
Loa Loa (eye worm) hypothetical protein 0.0031 0.0257 0.1107
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0232 0.0998
Echinococcus granulosus lamin dm0 0.0027 0.0213 0.0928
Entamoeba histolytica glycyl-tRNA synthetase, putative 0.0012 0.0057 0.0443
Toxoplasma gondii threonyl-tRNA synthetase family protein 0.0012 0.0057 0.0081
Wolbachia endosymbiont of Brugia malayi prolyl-tRNA synthetase 0.0012 0.0057 0.2114
Brugia malayi hypothetical protein 0.0044 0.0398 0.1724
Echinococcus multilocularis 6 phosphofructokinase 0.012 0.1215 0.529
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0015 0.0088 0.0383
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0019 0.0127 0.0187
Echinococcus granulosus solute carrier family 22 0.0031 0.0257 0.1119
Mycobacterium ulcerans histidyl-tRNA synthetase 0.0007 0.0004 0.0003
Schistosoma mansoni serine/threonine protein kinase 0.0059 0.0556 0.2423
Loa Loa (eye worm) beta-lactamase 0.0038 0.0327 0.141
Brugia malayi Major Facilitator Superfamily protein 0.0031 0.0257 0.1107
Echinococcus granulosus TGF beta signal transducer SmadC 0.0008 0.0014 0.0063
Toxoplasma gondii protein kinase, putative 0.0625 0.6633 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0008 0.0014 0.0049
Echinococcus multilocularis Threonyl tRNA synthetase, C 0.0012 0.0057 0.0248
Mycobacterium leprae Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase) (ThrRS) (Threonine-tRNA ligase) 0.0012 0.0057 0.0132
Schistosoma mansoni aspartyl-tRNA synthetase 0.0007 0.0003 0.0014
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0125 0.0122
Schistosoma mansoni caspase-3 (C14 family) 0.0019 0.0127 0.0555
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0272 0.1173
Loa Loa (eye worm) histidyl-tRNA synthetase 0.0007 0.0004 0.0002
Schistosoma mansoni smad 0.0008 0.0014 0.0063
Loa Loa (eye worm) hypothetical protein 0.0031 0.0257 0.1107
Mycobacterium tuberculosis Conserved protein 0.0038 0.0327 0.116
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0061 0.0576 0.2507
Trypanosoma cruzi hypothetical protein, conserved 0.0011 0.0041 0.0315
Toxoplasma gondii exonuclease III APE 0.0019 0.0125 0.0184
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0019 0.0127 0.0542
Loa Loa (eye worm) hypothetical protein 0.0012 0.0057 0.0234
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0066 0.0635 0.2766
Schistosoma mansoni glycyl-tRNA synthetase 0.0012 0.0057 0.0248
Onchocerca volvulus 0.0029 0.0232 0.0483
Echinococcus granulosus solute carrier family 22 0.0031 0.0257 0.1119
Trichomonas vaginalis CAMK family protein kinase 0.0068 0.0655 0.2844
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0061 0.0477
Schistosoma mansoni histidyl-tRNA synthetase 0.0007 0.0004 0.0015
Plasmodium vivax threonine--tRNA ligase, putative 0.0012 0.0057 0.0054
Plasmodium falciparum hexose transporter 0.0221 0.2296 0.2294
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0066 0.0635 0.2766
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0048 0.0443 0.1919
Echinococcus multilocularis synaptic vesicle 2 protein 0.0031 0.0257 0.1119
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0041 0.0166
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0084 0.0829 0.3205
Brugia malayi MH2 domain containing protein 0.0124 0.126 0.5482
Trypanosoma brucei hypothetical protein, conserved 0.0038 0.0327 0.2669
Echinococcus granulosus General substrate transporter 0.019 0.1963 0.8547
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0061 0.0477
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0032 0.0272 0.0269
Giardia lamblia Prolyl-tRNA synthetase 0.0066 0.0635 1
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0125 0.1009
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0127 0.0542
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0059 0.0556 0.4565
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0019 0.0127 0.0542
Brugia malayi beta-lactamase 0.0038 0.0327 0.141
Schistosoma mansoni aspartyl-tRNA synthetase 0.0007 0.0003 0.0014
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0096 0.0953 0.4151
Trichomonas vaginalis phosphofructokinase, putative 0.012 0.1215 0.5283
Leishmania major hypothetical protein, conserved 0.0011 0.0041 0.0315
Trypanosoma brucei trypanothione reductase 0.0037 0.032 0.2618
Trichomonas vaginalis myo-inositol transporter, putative 0.0031 0.0257 0.1107
Loa Loa (eye worm) hypothetical protein 0.0031 0.0257 0.1107
Toxoplasma gondii sugar transporter ST1 0.0031 0.0257 0.0383
Giardia lamblia Threonyl-tRNA synthetase 0.0012 0.0057 0.0849
Onchocerca volvulus 0.0031 0.0257 0.1127
Loa Loa (eye worm) hypothetical protein 0.0054 0.0502 0.2174
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0068 0.0655 0.2844
Toxoplasma gondii YbaK/proline-tRNA ligase associated domain-containing protein 0.0011 0.0041 0.0058
Leishmania major protein kinase, putative 0.0068 0.0655 0.5382
Trypanosoma brucei THT1 - hexose transporter, putative 0.0069 0.0659 0.5415
Brugia malayi MH1 domain containing protein 0.0008 0.0014 0.0049
Echinococcus multilocularis thioredoxin glutathione reductase 0.0037 0.0326 0.1418
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0031 0.0257 0.2095
Schistosoma mansoni ap endonuclease 0.0019 0.0125 0.0546
Trichomonas vaginalis CMGC family protein kinase 0.0059 0.0556 0.2412
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0257 0.1107
Plasmodium falciparum metacaspase 1 0.0019 0.0127 0.0124
Schistosoma mansoni sugar transporter 0.0031 0.0257 0.1119
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0068 0.0656 0.0653
Schistosoma mansoni sugar transporter 0.0031 0.0257 0.1119
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0013 0.0061 0.0058
Mycobacterium ulcerans hypothetical protein 0.0011 0.0041 0.0315
Plasmodium vivax hypothetical protein, conserved 0.0019 0.0127 0.0124
Wolbachia endosymbiont of Brugia malayi threonyl-tRNA synthetase 0.0012 0.0057 0.2114
Loa Loa (eye worm) sugar transporter 0.0031 0.0257 0.1107
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0009 0.0024 0.0093
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0063 0.0275
Trichomonas vaginalis sugar transporter, putative 0.0069 0.0659 0.2861
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0068 0.0655 0.2854
Trichomonas vaginalis CMGC family protein kinase 0.0059 0.0556 0.2412
Trypanosoma brucei THT1 - hexose transporter, putative 0.0069 0.0659 0.5415
Trichomonas vaginalis esterase, putative 0.0038 0.0327 0.141
Echinococcus multilocularis General substrate transporter 0.019 0.1963 0.8547
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0061 0.0477
Brugia malayi beta-lactamase family protein 0.0038 0.0327 0.141
Plasmodium vivax sugar transporter, putative 0.0031 0.0257 0.0254
Leishmania major glucose transporter/membrane transporter D2, putative 0.0069 0.0659 0.5415
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0068 0.0655 0.2854
Loa Loa (eye worm) transcription factor SMAD2 0.0124 0.126 0.5482
Schistosoma mansoni lysyl-tRNA synthetase 0.0049 0.0453 0.1973
Echinococcus granulosus caspase 2 0.0063 0.0602 0.2624
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0013 0.0061 0.0087
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0257 0.1107
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0257 0.1107
Loa Loa (eye worm) major facilitator superfamily transporter 0.0031 0.0257 0.1107
Echinococcus multilocularis asparaginyl tRNA synthetase 0.0007 0.0003 0.0014
Plasmodium falciparum mitogen-activated protein kinase 2 0.0357 0.3763 0.3761
Schistosoma mansoni hypothetical protein 0.0044 0.0398 0.1735
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0125 0.0533
Loa Loa (eye worm) hypothetical protein 0.0031 0.0257 0.1107
Toxoplasma gondii sugar transporter ST3 0.0031 0.0257 0.0383
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0257 0.1107
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0013 0.0061 0.0265
Onchocerca volvulus 0.0031 0.0257 0.1127
Loa Loa (eye worm) hypothetical protein 0.0038 0.0327 0.141
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0096 0.0953 0.4151
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0077 0.0753 0.6191
Trichomonas vaginalis glutathione reductase, putative 0.0013 0.0061 0.0252
Leishmania major glucose transporter, lmgt3 0.0069 0.0659 0.5415
Toxoplasma gondii thioredoxin reductase 0.0037 0.032 0.0478
Schistosoma mansoni hypothetical protein 0.0033 0.0279 0.1214
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0061 0.0576 0.2507
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0125 0.1009
Schistosoma mansoni aspartyl-tRNA synthetase 0.0007 0.0003 0.0014
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0032 0.0272 0.0269
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0048 0.0443 0.1919
Plasmodium vivax lysine--tRNA ligase, putative 0.0049 0.0453 0.045
Loa Loa (eye worm) MH2 domain-containing protein 0.0124 0.126 0.5482
Mycobacterium ulcerans lipase LipD 0.0038 0.0327 0.2669
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0019 0.0068
Trypanosoma brucei metacaspase 0.0019 0.0127 0.1025
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0096 0.0953 0.4143
Echinococcus multilocularis solute carrier family 22 0.0031 0.0257 0.1119
Schistosoma mansoni histidyl-tRNA synthetase 0.0007 0.0004 0.0015
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0213 0.0916
Echinococcus granulosus Threonyl tRNA synthetase C 0.0012 0.0057 0.0248
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0049 0.0453 0.3509
Brugia malayi beta-lactamase family protein 0.0038 0.0327 0.141
Schistosoma mansoni aspartyl-tRNA synthetase 0.0007 0.0003 0.0014
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0008 0.0014 0.0063
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0221 0.2296 1
Schistosoma mansoni Smad4 0.0008 0.0014 0.0063
Echinococcus multilocularis solute carrier family 22 0.0031 0.0257 0.1119
Echinococcus granulosus caspase 8 0.0019 0.0127 0.0555
Echinococcus multilocularis lamin 0.0027 0.0213 0.0928
Trichomonas vaginalis glucose transporter, putative 0.0069 0.0659 0.2861
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0257 0.1107
Loa Loa (eye worm) hypothetical protein 0.0027 0.0213 0.0916
Leishmania major threonyl-tRNA synthetase, putative 0.0012 0.0057 0.0443
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0063 0.0275
Leishmania major ATP-dependent phosphofructokinase 0.012 0.1215 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0096 0.0953 0.4151
Plasmodium falciparum glutathione reductase 0.0013 0.0061 0.0058
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0068 0.0655 0.2854
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0031 0.0257 1
Toxoplasma gondii phosphofructokinase PFKII 0.0032 0.0272 0.0406
Echinococcus granulosus synaptic vesicle 2 protein 0.0031 0.0257 0.1119
Echinococcus multilocularis solute carrier family 22 0.0031 0.0257 0.1119
Trypanosoma cruzi hexose transporter 0.0069 0.0659 0.5415
Trichomonas vaginalis interferon-induced, double-stranded RNA-activated protein kinase, putative 0.0007 0.0004 0.0002
Mycobacterium ulcerans glycyl-tRNA synthetase 0.0012 0.0057 0.0443
Brugia malayi Smad1 0.0008 0.0014 0.0049
Plasmodium falciparum threonine--tRNA ligase 0.0012 0.0057 0.0054
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0013 0.0061 0.0477
Trichomonas vaginalis glucose transporter, putative 0.0069 0.0659 0.2861
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0221 0.2296 1
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0032 0.0272 0.1173
Mycobacterium tuberculosis Probable reductase 0.0084 0.0829 0.3205
Loa Loa (eye worm) hypothetical protein 0.0031 0.0257 0.1107
Trypanosoma brucei glucose transporter, putative 0.0069 0.0659 0.5415
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0013 0.0061 0.0477
Schistosoma mansoni 6-phosphofructokinase 0.012 0.1215 0.529
Entamoeba histolytica hypothetical protein 0.004 0.0351 0.2869
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0257 0.1107
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0068 0.0655 0.2854
Trypanosoma cruzi glucose transporter, putative 0.0031 0.0257 0.2095
Echinococcus multilocularis beta LACTamase domain containing family member 0.0038 0.0327 0.1422
Trypanosoma cruzi hexose transporter, putative 0.0031 0.0257 0.2095
Echinococcus multilocularis mitogen activated protein kinase 3 0.0059 0.0556 0.2423
Brugia malayi MH2 domain containing protein 0.0008 0.0014 0.0049
Loa Loa (eye worm) hypothetical protein 0.0038 0.0327 0.141
Loa Loa (eye worm) hypothetical protein 0.0013 0.0063 0.0262
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0013 0.0061 0.0477
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0037 0.032 0.1136
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0272 0.1173
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0032 0.0272 0.2221
Schistosoma mansoni protein kinase 0.0068 0.0655 0.2854
Schistosoma mansoni caspase-7 (C14 family) 0.0063 0.0602 0.2624
Entamoeba histolytica phosphofructokinase, putative 0.012 0.1215 1
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0272 0.1173
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.0012 0.0057 0.0443
Onchocerca volvulus 0.0031 0.0257 0.1127
Onchocerca volvulus 0.0031 0.0257 0.1127
Plasmodium falciparum metacaspase-like protein 0.0019 0.0127 0.0124
Loa Loa (eye worm) phosphofructokinase 0.012 0.1215 0.5283
Echinococcus multilocularis glycyl tRNA synthetase 0.0012 0.0057 0.0248
Mycobacterium tuberculosis Possible penicillin-binding protein 0.024 0.2499 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0125 0.1009
Wolbachia endosymbiont of Brugia malayi histidyl-tRNA synthetase 0.0007 0.0004 0.0014
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0038 0.0327 0.141
Schistosoma mansoni smad1 5 8 and 0.0008 0.0014 0.0063
Plasmodium vivax glycine--tRNA ligase, putative 0.0012 0.0057 0.0054
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0019 0.0082
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0127 0.0542
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0049 0.0453 0.3713
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0019 0.0127 0.0542
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0077 0.0753 0.6191
Schistosoma mansoni aspartyl-tRNA synthetase 0.0007 0.0003 0.0014
Entamoeba histolytica hypothetical protein 0.004 0.0351 0.2869
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0066 0.0635 0.2766
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0084 0.0829 0.6713
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0257 0.1107
Schistosoma mansoni hypothetical protein 0.0015 0.0088 0.0383
Echinococcus granulosus solute carrier family 22 0.0031 0.0257 0.1119
Schistosoma mansoni sugar transporter 0.0031 0.0257 0.1119
Echinococcus granulosus calcium dependent protein kinase 0.0063 0.0605 0.2635
Schistosoma mansoni lamin 0.0027 0.0213 0.0928
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0125 0.1009
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0031 0.0257 0.1119
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0015 0.0088 0.0369
Leishmania major glycyl tRNA synthetase, putative 0.0007 0.0004 0.0003
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0084 0.0829 0.3205
Brugia malayi MAP kinase sur-1 0.0059 0.0556 0.2412
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.004 0.0351 0.1528
Plasmodium falciparum calcium-dependent protein kinase 1 0.0068 0.0656 0.0653
Trypanosoma brucei metacaspase MCA2 0.0019 0.0127 0.1025
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0272 0.1173
Trypanosoma brucei metacaspase MCA3 0.0019 0.0127 0.1025
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0019 0.0127 0.0542
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0041 0.0166
Plasmodium falciparum calcium-dependent protein kinase 3 0.0068 0.0656 0.0653
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0019 0.0082
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0013 0.0061 0.0477
Brugia malayi MH2 domain containing protein 0.0008 0.0014 0.0049
Echinococcus granulosus intermediate filament protein 0.0027 0.0213 0.0928
Trypanosoma brucei glucose transporter, putative 0.0069 0.0659 0.5415
Mycobacterium tuberculosis Probable oxidoreductase 0.0094 0.093 0.3616
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0257 0.1107
Schistosoma mansoni lysyl-tRNA synthetase 0.0049 0.0453 0.1973
Entamoeba histolytica phosphofructokinase, putative 0.012 0.1215 1
Schistosoma mansoni cpg binding protein 0.003 0.025 0.1087
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0096 0.0953 0.4151
Entamoeba histolytica phosphofructokinase, putative 0.012 0.1215 1
Schistosoma mansoni hypothetical protein 0.0221 0.2296 1
Plasmodium falciparum protein kinase 7 0.0625 0.6633 0.6632
Trypanosoma cruzi glycyl-tRNA synthetase, putative 0.0007 0.0004 0.0003
Onchocerca volvulus 0.0031 0.0257 0.1127
Echinococcus granulosus asparaginyl tRNA synthetase, cytoplasmic 0.0007 0.0003 0.0014
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0327 0.141
Echinococcus granulosus 6 phosphofructokinase 0.012 0.1215 0.529
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0059 0.0556 0.4565
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0327 0.141
Toxoplasma gondii histone lysine methyltransferase SET1 0.0054 0.0508 0.0761
Loa Loa (eye worm) hypothetical protein 0.0048 0.0443 0.1919
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0125 0.4816
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0019 0.0127 0.0187
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0061 0.0477
Onchocerca volvulus 0.0038 0.0327 0.2912
Trypanosoma brucei THT1 - hexose transporter, putative 0.0069 0.0659 0.5415
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0066 0.0635 0.2756
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0032 0.0272 0.5981
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0094 0.093 0.3616
Loa Loa (eye worm) hypothetical protein 0.0038 0.0327 0.141
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0576 0.4726
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0327 0.1422
Trichomonas vaginalis conserved hypothetical protein 0.0221 0.2296 1
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0077 0.0753 0.6191
Echinococcus granulosus lamin 0.0027 0.0213 0.0928
Loa Loa (eye worm) hypothetical protein 0.0063 0.0602 0.2613
Toxoplasma gondii anticodon binding domain-containing protein 0.0007 0.0004 0.0001
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0013 0.0061 0.0477
Brugia malayi Thioredoxin reductase 0.0037 0.032 0.1383
Onchocerca volvulus 0.0031 0.0257 0.1127
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0125 0.0122
Chlamydia trachomatis lysine--tRNA ligase 0.0049 0.0453 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0208 0.0892
Loa Loa (eye worm) hypothetical protein 0.0019 0.0127 0.0542
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0059 0.0556 0.0834
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0031 0.0257 0.0878
Leishmania major glucose transporter, lmgt1 0.0069 0.0659 0.5415
Trypanosoma cruzi trypanothione reductase, putative 0.0037 0.032 0.2618
Trichomonas vaginalis threonyl-tRNA synthetase, putative 0.0012 0.0057 0.0234
Plasmodium vivax metacaspase 1, putative 0.0019 0.0127 0.0124
Loa Loa (eye worm) hypothetical protein 0.0031 0.0257 0.1107
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.0012 0.0057 0.0443
Brugia malayi Sugar transporter family protein 0.0031 0.0257 0.1107
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0279 0.1202
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0013 0.0061 0.0477
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0272 0.1173
Echinococcus granulosus apoptotic protease activating factor 1 0.0044 0.0398 0.1735
Echinococcus granulosus aspartyl tRNA synthetase cytoplasmic 0.0007 0.0003 0.0014
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0327 0.1422
Treponema pallidum glycyl-tRNA synthetase 0.0007 0.0004 0.0003
Trypanosoma cruzi Aminoacyl-tRNA editing domain containing protein, putative 0.0011 0.0041 0.0315
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0019 0.0127 0.0542
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0031 0.0257 0.2095
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0013 0.0061 0.0058
Brugia malayi probable proline-trna synthetase - fission yeast, putative 0.0012 0.0057 0.0234
Mycobacterium tuberculosis Conserved protein 0.0038 0.0327 0.116
Brugia malayi intermediate filament protein 0.0027 0.0213 0.0916
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0059 0.0556 0.4565
Echinococcus multilocularis caspase 0.0019 0.0127 0.0555
Schistosoma mansoni hypothetical protein 0.0015 0.0088 0.0383
Echinococcus multilocularis aspartyl tRNA synthetase, cytoplasmic 0.0007 0.0003 0.0014
Mycobacterium ulcerans hypothetical protein 0.0038 0.0327 0.2669
Brugia malayi phosphofructokinase 0.012 0.1215 0.5283
Echinococcus granulosus Smad4 0.0008 0.0014 0.0063
Trypanosoma brucei protein kinase, putative 0.0059 0.0556 0.4565
Brugia malayi hypothetical protein 0.004 0.0351 0.1516
Toxoplasma gondii sugar transporter ST2 0.0031 0.0257 0.0383
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0096 0.0953 0.4143
Trypanosoma brucei Metacaspase-4 0.0019 0.0127 0.1025
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0018 0.0063
Mycobacterium tuberculosis Probable lipase LipE 0.0038 0.0327 0.116
Toxoplasma gondii facilitative glucose transporter GT1 0.0221 0.2296 0.3459
Brugia malayi threonyl-tRNA synthetase, cytoplasmic 0.0012 0.0057 0.0234
Onchocerca volvulus 0.0031 0.0257 0.1127
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.012 0.1215 1
Schistosoma mansoni cpg binding protein 0.003 0.025 0.1087
Plasmodium falciparum proline--tRNA ligase 0.0077 0.0753 0.075
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0042 0.0373 0.2828
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0038 0.0327 0.2669
Brugia malayi Cell death protein 3 precursor 0.0063 0.0602 0.2613
Onchocerca volvulus 0.0031 0.0257 0.1127
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0061 0.0576 0.2175
Entamoeba histolytica protein kinase, putative 0.0068 0.0655 0.5382
Mycobacterium tuberculosis Probable dehydrogenase 0.0084 0.0829 0.3205
Trichomonas vaginalis CMGC family protein kinase 0.0059 0.0556 0.2412
Brugia malayi 6-phosphofructokinase 0.012 0.1215 0.5283
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0038 0.0327 0.141
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0257 0.1107
Entamoeba histolytica hypothetical protein 0.004 0.0351 0.2869
Mycobacterium ulcerans 6-phosphofructokinase 0.012 0.1215 1
Toxoplasma gondii NADPH-glutathione reductase 0.0013 0.0061 0.0087
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0068 0.0656 0.0653
Trypanosoma cruzi metacaspase 5, putative 0.0019 0.0127 0.1025
Leishmania major myo-inositol/proton symporter (MIT) 0.0031 0.0257 0.2095
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0032 0.0272 0.0406
Loa Loa (eye worm) hypothetical protein 0.0031 0.0257 0.1107
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0068 0.0656 0.0653
Trypanosoma brucei histidyl-tRNA synthetase 0.0007 0.0004 0.0003

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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