Detailed information for compound 71367

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 411.449 | Formula: C26H21NO4
  • H donors: 2 H acceptors: 2 LogP: 6.02 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(c2c1cc(o2)c1ccc([nH]1)c1ccc(c2c1cccc2)C(=O)O)CC
  • InChi: 1S/C26H21NO4/c1-3-15-8-13-23(30-2)20-14-24(31-25(15)20)22-12-11-21(27-22)18-9-10-19(26(28)29)17-7-5-4-6-16(17)18/h4-14,27H,3H2,1-2H3,(H,28,29)
  • InChiKey: SCNJILJYLFUEPC-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0018 0.003 0.003
Toxoplasma gondii endonuclease IV APN 0.0079 0.0359 1
Schistosoma mansoni voltage-gated cation channel 0.0192 0.0968 0.0968
Brugia malayi cytochrome P450 0.0018 0.0033 0.0033
Onchocerca volvulus Netrin receptor homolog 0.0018 0.0028 0.0025
Brugia malayi Fibronectin type III domain containing protein 0.0016 0.002 0.002
Echinococcus multilocularis nuclear receptor nhr 48 0.0042 0.0158 0.0158
Loa Loa (eye worm) hypothetical protein 0.0042 0.0158 0.0158
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.01 0.0476 0.0476
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0013 0.0004 0.0004
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0088 0.0409 0.0409
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0088 0.0409 0.0409
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0018 0.0033 0.0033
Leishmania major hypothetical protein, conserved 0.0026 0.0073 0.2586
Loa Loa (eye worm) hypothetical protein 0.0042 0.0158 0.0158
Loa Loa (eye worm) hypothetical protein 0.0088 0.0409 0.0409
Loa Loa (eye worm) cytochrome P450 0.0018 0.0033 0.0033
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0088 0.0409 0.0409
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0133 0.0133
Loa Loa (eye worm) hypothetical protein 0.0015 0.0016 0.0016
Plasmodium vivax hypothetical protein, conserved 0.0015 0.0016 0.0129
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0038 0.0137 0.0137
Echinococcus granulosus twitchin 0.0014 0.0007 0.0007
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0073 0.1797
Echinococcus granulosus phd:f box containing protein 0.0016 0.0021 0.0021
Echinococcus granulosus neuroglian 0.0014 0.0007 0.0007
Brugia malayi nuclear receptor NHR-88 0.0042 0.0158 0.0158
Loa Loa (eye worm) hypothetical protein 0.007 0.0312 0.0312
Echinococcus granulosus ecdysone induced protein 78C 0.0088 0.0409 0.0409
Giardia lamblia MRP-like ABC transporter 0.0014 0.001 0.0001
Schistosoma mansoni tyrosine kinase 0.0058 0.0247 0.0247
Schistosoma mansoni lamin 0.0028 0.0083 0.0083
Schistosoma mansoni glycogen phosphorylase 0.1865 1 1
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0027 0.0078 0.1952
Loa Loa (eye worm) hypothetical protein 0.0013 0.0003 0.0003
Schistosoma mansoni multiple ankyrin repeats single kh domain protein 0.0092 0.0432 0.0432
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.0105 0.0105
Schistosoma mansoni nuclear hormone receptor 0.0042 0.0158 0.0158
Echinococcus multilocularis endonuclease reverse transcriptase 0.0015 0.0016 0.0016
Echinococcus multilocularis epidermal growth factor receptor 0.0096 0.0451 0.0451
Mycobacterium tuberculosis Probable glycogen phosphorylase GlgP 0.0806 0.4286 1
Loa Loa (eye worm) hypothetical protein 0.0192 0.0968 0.0968
Loa Loa (eye worm) hypothetical protein 0.0016 0.002 0.002
Echinococcus granulosus neuropeptide receptor A26 0.0938 0.4999 0.4999
Schistosoma mansoni nuclear receptor 0.0042 0.0158 0.0158
Loa Loa (eye worm) ABC transporter transmembrane region family protein 0.0014 0.001 0.001
Trichomonas vaginalis guanylate cyclase, putative 0.0013 0.0004 0.0004
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0015 0.0013 0.0013
Brugia malayi latrophilin 2 splice variant baaae 0.0069 0.0304 0.0304
Loa Loa (eye worm) hypothetical protein 0.0013 0.0006 0.0006
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0076 0.0342 0.0342
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0088 0.0409 0.0409
Echinococcus granulosus endonuclease reverse transcriptase 0.0015 0.0016 0.0016
Entamoeba histolytica hypothetical protein 0.0015 0.0016 0.0005
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0016 0.0021 0.0021
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0018 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.0046 0.0185 0.0185
Echinococcus multilocularis Ankyrin 0.0015 0.0014 0.0014
Brugia malayi conserved hypotetical protein 0.0042 0.0158 0.0158
Schistosoma mansoni ap endonuclease 0.0039 0.0144 0.0144
Plasmodium vivax JmjC domain containing protein 0.0016 0.0021 0.0279
Echinococcus granulosus insulin receptor 0.0058 0.0247 0.0247
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0088 0.0409 0.0409
Schistosoma mansoni hypothetical protein 0.0018 0.0033 0.0033
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0018 0.0033 0.1071
Toxoplasma gondii GCC2 and GCC3 domain-containing protein 0.0015 0.0016 0.0156
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0042 0.0158 0.0158
Entamoeba histolytica hypothetical protein 0.0037 0.0133 0.0123
Brugia malayi GCC2 and GCC3 family protein 0.0015 0.0016 0.0016
Giardia lamblia CEGP1 protein 0.0015 0.0016 0.0006
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.0103 0.0103
Loa Loa (eye worm) hypothetical protein 0.0042 0.0158 0.0158
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0039 0.0144 0.0144
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0014 0.0014
Schistosoma mansoni single-minded 0.005 0.0203 0.0203
Toxoplasma gondii hypothetical protein 0.0015 0.0016 0.0156
Treponema pallidum exodeoxyribonuclease (exoA) 0.0039 0.0144 0.5
Schistosoma mansoni tyrosine kinase 0.0096 0.0451 0.0451
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0037 0.0132 0.0233
Brugia malayi Protein kinase domain containing protein 0.0015 0.0013 0.0013
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0073 0.1136
Echinococcus multilocularis neuroglian 0.0014 0.0007 0.0007
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0039 0.0144 0.0134
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0042 0.0158 0.0158
Plasmodium falciparum flap endonuclease 1 0.0027 0.0078 0.1825
Onchocerca volvulus 0.0028 0.0083 0.0079
Echinococcus multilocularis 0.0018 0.0033 0.0033
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0033 0.0033
Entamoeba histolytica hypothetical protein, conserved 0.0015 0.0016 0.0005
Loa Loa (eye worm) hypothetical protein 0.0013 0.0004 0.0004
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0088 0.0409 0.0409
Schistosoma mansoni netrin receptor unc5 0.0018 0.0033 0.0033
Onchocerca volvulus 0.0042 0.0158 0.0154
Echinococcus multilocularis cpg binding protein 0.0031 0.0102 0.0102
Echinococcus granulosus thyroid hormone receptor alpha 0.0042 0.0158 0.0158
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0013 0.0006 0.0006
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0192 0.0968 0.0968
Schistosoma mansoni voltage-gated potassium channel 0.0046 0.0183 0.0183
Brugia malayi nuclear receptor RXR 0.0042 0.0158 0.0158
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0043 0.0164 0.0164
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0046 0.0185 0.0185
Brugia malayi Nuclear hormone receptor-like 1 0.0046 0.0185 0.0185
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0073 0.169
Loa Loa (eye worm) CYP4Cod1 0.0037 0.0132 0.0132
Echinococcus multilocularis histone acetyltransferase myst3 0.0012 0.0001 0.0001
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0063 0.0273 0.0273
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0093 0.0093
Trichomonas vaginalis flap endonuclease-1, putative 0.0027 0.0078 0.0078
Echinococcus granulosus tumor protein p63 0.0347 0.1807 0.1807
Leishmania major ATP-binding cassette protein subfamily C, member 1, putative 0.0014 0.001 0.0232
Toxoplasma gondii kringle domain-containing protein 0.0015 0.0016 0.0156
Brugia malayi hypothetical protein 0.0017 0.0024 0.0024
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0016 0.0021 0.0299
Echinococcus multilocularis lamin 0.0028 0.0083 0.0083
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0039 0.0144 0.5
Giardia lamblia Multidrug resistance-associated protein 1 0.0014 0.001 0.0001
Echinococcus multilocularis voltage gated potassium channel 0.0016 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0015 0.0016 0.0016
Toxoplasma gondii exonuclease III APE 0.0039 0.0144 0.3833
Schistosoma mansoni ap endonuclease 0.0039 0.0144 0.0144
Giardia lamblia ABC transporter, putative 0.0014 0.001 0.0001
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0088 0.0409 0.0409
Loa Loa (eye worm) hypothetical protein 0.0028 0.0083 0.0083
Echinococcus granulosus FTZ F1 alpha 0.0088 0.0409 0.0409
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0016 0.0016
Echinococcus multilocularis multidrug resistance associated protein 7 0.0014 0.001 0.001
Trichomonas vaginalis set domain proteins, putative 0.0244 0.125 0.125
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0088 0.0409 0.0409
Loa Loa (eye worm) hypothetical protein 0.0042 0.0158 0.0158
Loa Loa (eye worm) hypothetical protein 0.0046 0.0185 0.0185
Loa Loa (eye worm) hypothetical protein 0.0104 0.0495 0.0495
Echinococcus granulosus glycogen phosphorylase 0.1865 1 1
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0027 0.0078 0.2758
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.027 0.0559
Entamoeba histolytica glycogenphosphorylase, putative 0.0806 0.4286 0.428
Brugia malayi Nuclear hormone receptor E75 0.0042 0.0158 0.0158
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0039 0.0144 0.2395
Loa Loa (eye worm) hypothetical protein 0.0035 0.0122 0.0122
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0016 0.0021 0.0299
Loa Loa (eye worm) hypothetical protein 0.0088 0.0409 0.0409
Loa Loa (eye worm) hypothetical protein 0.0032 0.0105 0.0105
Echinococcus granulosus epidermal growth factor receptor 0.0176 0.0885 0.0885
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0015 0.0014 0.0014
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0039 0.0144 0.0261
Mycobacterium ulcerans putative regulatory protein 0.0037 0.0133 0.0237
Brugia malayi Cytochrome P450 family protein 0.0037 0.0132 0.0132
Brugia malayi GCC2 and GCC3 family protein 0.0015 0.0016 0.0016
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0021 0.0021
Brugia malayi CXXC zinc finger family protein 0.0029 0.0093 0.0093
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0021 0.0021
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0088 0.0409 0.0409
Echinococcus granulosus voltage dependent calcium channel 0.0042 0.0161 0.0161
Brugia malayi nuclear hormone receptor 0.0088 0.0409 0.0409
Brugia malayi steroid hormone receptor 0.0088 0.0409 0.0409
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0043 0.0166 0.0166
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0064 0.0278 0.0278
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0083 0.0083
Mycobacterium leprae PROBABLE ENDONUCLEASE IV END (ENDODEOXYRIBONUCLEASE IV) (APURINASE) 0.0079 0.0359 1
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0016 0.0019 0.0019
Loa Loa (eye worm) cytochrome P450 family protein 0.0037 0.0132 0.0132
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0103 0.0103
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0033 0.0033
Brugia malayi orphan nuclear receptor NR2E1 0.0042 0.0158 0.0158
Mycobacterium tuberculosis Conserved hypothetical protein 0.0021 0.0046 0.003
Echinococcus multilocularis roundabout 2 0.0022 0.0054 0.0054
Onchocerca volvulus Putative hydroxypyruvate isomerase 0.0021 0.0046 0.0042
Schistosoma mansoni thyroid hormone receptor 0.0088 0.0409 0.0409
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.006 0.026 0.026
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0088 0.0409 0.0409
Loa Loa (eye worm) hypothetical protein 0.0017 0.0026 0.0026
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0088 0.0409 0.0409
Trichomonas vaginalis adenylate cyclase, type VII, putative 0.0013 0.0004 0.0004
Plasmodium vivax cysteine repeat modular protein 3, putative 0.0015 0.0016 0.0129
Brugia malayi CHD4 protein 0.0013 0.0006 0.0006
Echinococcus multilocularis neuropeptide s receptor 0.0938 0.4999 0.4999
Giardia lamblia Hypothetical protein 0.0015 0.0016 0.0006
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0088 0.0409 0.0409
Echinococcus multilocularis lysine specific demethylase 5A 0.006 0.026 0.026
Trichomonas vaginalis ap endonuclease, putative 0.0039 0.0144 0.0144
Brugia malayi Cytochrome P450 family protein 0.0018 0.0033 0.0033
Echinococcus multilocularis microtubule associated protein 2 0.0709 0.3759 0.3759
Onchocerca volvulus 0.0028 0.0083 0.0079
Echinococcus granulosus histone acetyltransferase myst3 0.0012 0.0001 0.0001
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0088 0.0409 0.0409
Loa Loa (eye worm) hypothetical protein 0.0016 0.0021 0.0021
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0013 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0051 0.0208 0.0208
Loa Loa (eye worm) nuclear hormone receptor 0.0042 0.0158 0.0158
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0015 0.0014 0.0014
Brugia malayi exodeoxyribonuclease III family protein 0.0039 0.0144 0.0144
Echinococcus granulosus Glycosyl transferase family 35 0.1865 1 1
Echinococcus multilocularis JmjC domain containing protein 4 0.0016 0.0021 0.0021
Echinococcus granulosus glycogen phosphorylase 0.1865 1 1
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.027 0.027
Loa Loa (eye worm) hypothetical protein 0.0015 0.0016 0.0016
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0046 0.0185 0.0185
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0088 0.0409 0.0409
Trichomonas vaginalis ap endonuclease, putative 0.0039 0.0144 0.0144
Schistosoma mansoni RAR-like nuclear receptor 0.0088 0.0409 0.0409
Schistosoma mansoni aryl hydrocarbon receptor 0.005 0.0203 0.0203
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0018 0.0033 0.0511
Loa Loa (eye worm) hypothetical protein 0.0031 0.0103 0.0103
Trichomonas vaginalis adenylate cyclase, putative 0.0013 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0015 0.0014 0.0014
Onchocerca volvulus 0.0043 0.0166 0.0162
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.006 0.026 0.026
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0013 0.0004 0.0004
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.027 0.0559
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0088 0.0409 0.0409
Loa Loa (eye worm) pigment dispersing factor receptor c 0.01 0.0476 0.0476
Schistosoma mansoni ankyrin 23/unc44 0.0015 0.0013 0.0013
Schistosoma mansoni voltage-gated potassium channel 0.0016 0.0019 0.0019
Echinococcus granulosus flap endonuclease 1 0.0027 0.0078 0.0078
Schistosoma mansoni multiple ankyrin repeats single kh domain protein 0.0092 0.0432 0.0432
Echinococcus multilocularis tumor protein p63 0.0347 0.1807 0.1807
Entamoeba histolytica glycogen phosphorylase, putative 0.1865 1 1
Mycobacterium leprae Conserved hypothetical protein 0.0018 0.0033 0.0813
Schistosoma mansoni steroid hormone receptor ad4bp 0.0088 0.0409 0.0409
Loa Loa (eye worm) hypothetical protein 0.0088 0.0409 0.0409
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0062 0.027 0.027
Echinococcus multilocularis lamin dm0 0.0028 0.0083 0.0083
Trypanosoma cruzi cytochrome P450, putative 0.0037 0.0132 0.227
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0043 0.0164 0.0164
Schistosoma mansoni tyrosine kinase 0.0176 0.0885 0.0885
Schistosoma mansoni protein phosphatase 2C 0.0016 0.0021 0.0021
Schistosoma mansoni nuclear hormone receptor 0.0042 0.0158 0.0158
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0039 0.0144 0.0261
Loa Loa (eye worm) hypothetical protein 0.0042 0.0158 0.0158
Loa Loa (eye worm) hypothetical protein 0.0016 0.0021 0.0021
Entamoeba histolytica hypothetical protein 0.0037 0.0133 0.0123
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.027 0.0559
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0043 0.0164 0.0164
Schistosoma mansoni voltage-gated potassium channel 0.0016 0.0019 0.0019
Echinococcus granulosus Ankyrin 0.0015 0.0014 0.0014
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0088 0.0409 0.0409
Echinococcus multilocularis GPCR, family 2 0.0032 0.0105 0.0105
Brugia malayi Immunoglobulin I-set domain containing protein 0.0018 0.0033 0.0033
Onchocerca volvulus 0.0161 0.0802 0.0798
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0214 0.1091 0.1091
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0096 0.0451 0.0451
Echinococcus granulosus multidrug resistance associated protein 7 0.0014 0.001 0.001
Schistosoma mansoni tyrosine kinase 0.0092 0.0432 0.0432
Echinococcus multilocularis epidermal growth factor receptor 0.0176 0.0885 0.0885
Brugia malayi Nuclear hormone receptor-like 1 0.0046 0.0185 0.0185
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0248 0.127 0.127
Echinococcus granulosus nuclear factor of activated T cells 5 0.0076 0.0342 0.0342
Leishmania major ATP-binding cassette protein subfamily C, member 5, putative 0.0014 0.001 0.0232
Brugia malayi Furin-like cysteine rich region family protein 0.0176 0.0885 0.0885
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0033 0.0033
Brugia malayi hypothetical protein 0.0037 0.0133 0.0133
Schistosoma mansoni voltage-gated potassium channel 0.0046 0.0183 0.0183
Toxoplasma gondii histone lysine methyltransferase SET1 0.0057 0.0241 0.6638
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0192 0.0968 0.0968
Brugia malayi hypothetical protein 0.0026 0.0073 0.0073
Leishmania major cytochrome p450-like protein 0.0037 0.0132 0.4755
Brugia malayi PAS domain containing protein 0.005 0.0203 0.0203
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0103 0.2658
Plasmodium vivax flap endonuclease 1, putative 0.0027 0.0078 0.193
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.0042 0.0158 0.0158
Schistosoma mansoni multidrug resistance protein 0.0014 0.001 0.001
Onchocerca volvulus 0.0029 0.0093 0.0089
Entamoeba histolytica protein kinase, putative 0.0015 0.0016 0.0005
Echinococcus granulosus microtubule associated protein 2 0.0709 0.3759 0.3759
Schistosoma mansoni multidrug resistance protein 0.0014 0.001 0.001
Schistosoma mansoni retinoic acid receptor RXR 0.0088 0.0409 0.0409
Leishmania major ATP-binding cassette protein subfamily C, member 2, putative 0.0014 0.001 0.0232
Brugia malayi hypothetical protein 0.0042 0.0158 0.0158
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0004 0.0004
Schistosoma mansoni ephrin receptor 0.0141 0.0696 0.0696
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.0105 0.0105
Entamoeba histolytica hypothetical protein 0.0037 0.0133 0.0123
Loa Loa (eye worm) voltage-dependent calcium channel 0.0042 0.0161 0.0161
Giardia lamblia Glycogen phosphorylase 0.1865 1 1
Brugia malayi ABC transporter transmembrane region family protein 0.0014 0.001 0.001
Echinococcus multilocularis aryl hydrocarbon receptor 0.0013 0.0004 0.0004
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0035 0.0125 0.0125
Brugia malayi Immunoglobulin I-set domain containing protein 0.0179 0.0898 0.0898
Loa Loa (eye worm) hypothetical protein 0.0088 0.0409 0.0409
Loa Loa (eye worm) CHromoDomain protein family member 0.0013 0.0006 0.0006
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0039 0.0144 0.3735
Echinococcus granulosus Nuclear hormone receptor HR96 0.0042 0.0158 0.0158
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0088 0.0409 0.0409
Trypanosoma cruzi multidrug resistance-associated protein, putative 0.0014 0.001 0.0111
Loa Loa (eye worm) glycogen phosphorylase 0.1865 1 1
Brugia malayi Protein kinase domain containing protein 0.0058 0.0247 0.0247
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0088 0.0409 0.0409
Loa Loa (eye worm) hypothetical protein 0.0042 0.0158 0.0158
Toxoplasma gondii transporter, cation channel family protein 0.0042 0.0161 0.4326
Brugia malayi Nuclear hormone receptor-like 1 0.0088 0.0409 0.0409
Loa Loa (eye worm) hypothetical protein 0.0014 0.001 0.001
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0016 0.0019 0.0019
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0103 0.0103
Entamoeba histolytica glycogen phosphorylase, putative 0.1865 1 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0016 0.0016
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0013 0.0004 0.0004
Echinococcus granulosus single minded 2 0.004 0.0152 0.0152
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0088 0.0409 0.0409
Plasmodium vivax apurinic/apyrimidinic endonuclease Apn1, putative 0.0079 0.0359 1
Brugia malayi jmjC domain containing protein 0.006 0.026 0.026
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0083 0.038 0.038
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0055 0.023 0.023
Leishmania major ABC-thiol transporter 0.0014 0.001 0.0232
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0039 0.0144 0.5192
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0046 0.0185 0.0185
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0042 0.0158 0.0154
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0088 0.0409 0.0409
Echinococcus granulosus cytochrome P450 2K1 0.0018 0.0033 0.0033
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0033 0.0033
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0088 0.0409 0.0409
Loa Loa (eye worm) hypothetical protein 0.0016 0.0021 0.0021
Loa Loa (eye worm) nuclear receptor NHR-67 0.0042 0.0158 0.0158
Echinococcus multilocularis lysine specific demethylase 6a 0.0016 0.0021 0.0021
Schistosoma mansoni hypothetical protein 0.0341 0.1777 0.1777
Schistosoma mansoni vesicular amine transporter 0.0018 0.0032 0.0032
Echinococcus granulosus death domain containing protein 0.0015 0.0013 0.0013
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0039 0.0144 0.0134
Loa Loa (eye worm) TK/INSR protein kinase 0.0058 0.0247 0.0247
Loa Loa (eye worm) hypothetical protein 0.0046 0.0185 0.0185
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0088 0.0409 0.0409
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0042 0.0158 0.0154
Echinococcus granulosus roundabout 2 0.0022 0.0054 0.0054
Schistosoma mansoni glycogen phosphorylase 0.0806 0.4286 0.4286
Echinococcus granulosus jumonji domain containing 1A 0.0016 0.0021 0.0021
Brugia malayi nuclear receptor NHR-88 0.0088 0.0409 0.0409
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0088 0.0409 0.0409
Brugia malayi Cytochrome P450 family protein 0.0037 0.0132 0.0132
Brugia malayi photoreceptor-specific nuclear receptor 0.0088 0.0409 0.0409
Brugia malayi Cytochrome P450 family protein 0.0058 0.0244 0.0244
Leishmania major hypothetical protein, conserved 0.0016 0.0021 0.0626
Echinococcus granulosus nuclear receptor nhr 48 0.0042 0.0158 0.0158
Brugia malayi Flap endonuclease-1 0.0027 0.0078 0.0078
Schistosoma mansoni jumonji/arid domain-containing protein 0.0062 0.0269 0.0269
Loa Loa (eye worm) cytochrome P450 family protein 0.0037 0.0132 0.0132
Loa Loa (eye worm) hypothetical protein 0.0042 0.0158 0.0158
Schistosoma mansoni nuclear hormone receptor 0.0088 0.0409 0.0409
Schistosoma mansoni flap endonuclease-1 0.0024 0.0064 0.0064
Loa Loa (eye worm) TK/EPH protein kinase 0.0179 0.09 0.09
Plasmodium falciparum apurinic/apyrimidinic endonuclease Apn1, putative 0.0079 0.0359 1
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0042 0.0158 0.0158
Loa Loa (eye worm) hypothetical protein 0.0013 0.0003 0.0003
Leishmania major cytochrome p450-like protein 0.0018 0.0033 0.1071
Schistosoma mansoni nuclear receptor 0.0042 0.0158 0.0158
Brugia malayi hypothetical protein 0.0104 0.0496 0.0496
Loa Loa (eye worm) hypothetical protein 0.0046 0.0185 0.0185
Onchocerca volvulus 0.0104 0.0495 0.0492
Giardia lamblia Flap structure-specific endonuclease 0.0027 0.0078 0.0069
Brugia malayi multidrug resistance related protein 1 0.0014 0.001 0.001
Mycobacterium leprae putative cytochrome p450 0.0018 0.0033 0.0813
Brugia malayi nuclear hormone receptor family member nhr-6 0.0042 0.0158 0.0158
Echinococcus granulosus geminin 0.0341 0.1777 0.1777
Brugia malayi GCC2 and GCC3 family protein 0.0015 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.0042 0.0158 0.0158
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0088 0.0409 0.0409
Plasmodium falciparum JmjC domain-containing protein, putative 0.0016 0.0021 0.0151
Echinococcus multilocularis flap endonuclease 1 0.0027 0.0078 0.0078
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0088 0.0409 0.0409
Echinococcus granulosus lysine specific demethylase 5A 0.0062 0.0269 0.0269
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0088 0.0409 0.0409
Trichomonas vaginalis glycogen phosphorylase, putative 0.1865 1 1
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0027 0.0078 0.1219
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0063 0.0275 0.0275
Entamoeba histolytica glycogen phosphorylase, putative 0.0806 0.4286 0.428
Echinococcus multilocularis glycogen phosphorylase 0.1865 1 1
Onchocerca volvulus 0.0015 0.0016 0.0012
Echinococcus granulosus JmjC domain containing protein 4 0.0016 0.0021 0.0021
Brugia malayi nuclear receptor NHR-67 0.0042 0.0158 0.0158
Schistosoma mansoni thyroid hormone receptor 0.0088 0.0409 0.0409
Brugia malayi hypothetical protein 0.0046 0.0185 0.0185
Brugia malayi intermediate filament protein 0.0028 0.0083 0.0083
Loa Loa (eye worm) hypothetical protein 0.0042 0.0158 0.0158
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0073 0.1234
Echinococcus granulosus neuropeptide s receptor 0.0938 0.4999 0.4999
Loa Loa (eye worm) hypothetical protein 0.0088 0.0409 0.0409
Mycobacterium tuberculosis Probable endonuclease IV End (endodeoxyribonuclease IV) (apurinase) 0.0079 0.0359 0.0766
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0042 0.0158 0.0158
Schistosoma mansoni hypothetical protein 0.0341 0.1777 0.1777
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0006 0.0006
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0192 0.0968 0.0968
Schistosoma mansoni hypothetical protein 0.0069 0.0304 0.0304
Loa Loa (eye worm) jmjC domain-containing protein 0.0062 0.0269 0.0269
Leishmania major pentamidine resistance protein 1 0.0014 0.001 0.0232
Loa Loa (eye worm) hypothetical protein 0.0088 0.0409 0.0409
Trypanosoma cruzi multidrug resistance-associated protein, putative 0.0014 0.001 0.0111
Mycobacterium leprae conserved hypothetical protein 0.0021 0.0046 0.1174
Schistosoma mansoni cytochrome P450 0.0018 0.0033 0.0033
Echinococcus multilocularis multidrug resistance associated protein 1 0.0014 0.001 0.001
Brugia malayi bHLH-PAS transcription factor 0.0037 0.0133 0.0133
Loa Loa (eye worm) hypothetical protein 0.0018 0.0033 0.0033
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0039 0.0144 0.2479
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0035 0.0125 0.0125
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0046 0.0185 0.0185
Loa Loa (eye worm) hypothetical protein 0.0168 0.0838 0.0838
Schistosoma mansoni hypothetical protein 0.042 0.2201 0.2201
Loa Loa (eye worm) hypothetical protein 0.0104 0.0496 0.0496
Schistosoma mansoni intermediate filament proteins 0.0028 0.0083 0.0083
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0103 0.0103
Echinococcus granulosus multidrug resistance associated protein 1 0.0014 0.001 0.001
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0073 0.1819
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0192 0.0968 0.0968
Brugia malayi Nuclear hormone receptor E75 0.0042 0.0158 0.0158
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0088 0.0409 0.0409
Schistosoma mansoni microtubule-associated protein tau 0.0709 0.3759 0.3759
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0063 0.0273 0.0273
Loa Loa (eye worm) hypothetical protein 0.0021 0.0046 0.0046
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0006 0.0006
Echinococcus multilocularis 0.0054 0.0224 0.0224
Brugia malayi Pre-SET motif family protein 0.0031 0.0103 0.0103
Echinococcus granulosus GPCR family 2 0.0032 0.0105 0.0105
Echinococcus multilocularis dnaJ subfamily B 0.042 0.2201 0.2201
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0088 0.0409 0.0405
Schistosoma mansoni coup transcription factor 0.0088 0.0409 0.0409
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0063 0.0275 0.0275
Brugia malayi Latrophilin receptor protein 2 0.0032 0.0105 0.0105
Brugia malayi Pre-SET motif family protein 0.0214 0.1091 0.1091
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0088 0.0409 0.0409
Echinococcus granulosus aryl hydrocarbon receptor 0.0013 0.0004 0.0004
Onchocerca volvulus 0.0042 0.0158 0.0154
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0088 0.0409 0.0409
Toxoplasma gondii hypothetical protein 0.0035 0.0122 0.3201
Brugia malayi ecdysone receptor 0.0042 0.0158 0.0158
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0063 0.0273 0.0273
Schistosoma mansoni cpg binding protein 0.0029 0.0093 0.0093
Onchocerca volvulus Tyrosine kinase homolog 0.0167 0.0835 0.0832
Echinococcus granulosus intermediate filament protein 0.0028 0.0083 0.0083
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0063 0.0273 0.0565
Echinococcus granulosus netrin receptor unc 5 0.0018 0.0033 0.0033
Loa Loa (eye worm) hypothetical protein 0.0042 0.0158 0.0158
Echinococcus granulosus voltage gated potassium channel 0.0016 0.0019 0.0019
Schistosoma mansoni zinc finger protein 0.0042 0.0158 0.0158
Loa Loa (eye worm) hypothetical protein 0.0014 0.0011 0.0011
Brugia malayi ephrin receptor 1 precursor 0.0068 0.0303 0.0303
Brugia malayi Immunoglobulin I-set domain containing protein 0.0016 0.002 0.002
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0033 0.0033
Echinococcus multilocularis phd:f box containing protein 0.0016 0.0021 0.0021
Brugia malayi hypothetical protein 0.0046 0.0185 0.0185
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0042 0.0158 0.0158
Brugia malayi jmjC domain containing protein 0.0016 0.0021 0.0021
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.0105 0.0105
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0014 0.0011 0.0011
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0039 0.0144 0.2479
Echinococcus multilocularis jumonji domain containing 1A 0.0016 0.0021 0.0021
Echinococcus multilocularis transfer RNA-Lys 0.0037 0.0133 0.0133
Echinococcus multilocularis Glycosyl transferase, family 35 0.1865 1 1
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0013 0.0004 0.0004
Echinococcus granulosus Ankyrin repeat domain containing protein 0.0092 0.0432 0.0432
Plasmodium vivax SET domain protein, putative 0.0031 0.0103 0.2638
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0192 0.0968 0.0968
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0015 0.0013 0.0013
Mycobacterium ulcerans glycogen phosphorylase GlgP 0.0806 0.4286 1
Trypanosoma cruzi cytochrome P450, putative 0.0037 0.0132 0.227
Schistosoma mansoni cpg binding protein 0.0031 0.0102 0.0102
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0027 0.0078 0.1317
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0046 0.0185 0.0185
Entamoeba histolytica hypothetical protein 0.0037 0.0133 0.0123
Brugia malayi ecdysteroid receptor 0.0088 0.0409 0.0409
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0042 0.0158 0.0158
Schistosoma mansoni hypothetical protein 0.0032 0.0105 0.0105
Echinococcus granulosus cpg binding protein 0.0031 0.0102 0.0102
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0133 0.0133
Onchocerca volvulus 0.0088 0.0409 0.0405
Brugia malayi SET domain containing protein 0.0013 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0015 0.0013 0.0013
Schistosoma mansoni hypothetical protein 0.0032 0.0105 0.0105
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0063 0.0273 0.0565
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0103 0.0103
Loa Loa (eye worm) hypothetical protein 0.0016 0.002 0.002
Onchocerca volvulus 0.0104 0.0495 0.0492
Loa Loa (eye worm) hypothetical protein 0.0088 0.0409 0.0409
Echinococcus granulosus Nuclear hormone receptor HR96 0.0042 0.0158 0.0158
Loa Loa (eye worm) hypothetical protein 0.0079 0.0359 0.0359
Echinococcus multilocularis netrin receptor unc 5 0.0018 0.0033 0.0033
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0013 0.0006 0.0006
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0088 0.0409 0.0409
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.0105 0.0105
Brugia malayi Uncoordinated protein 44 0.0015 0.0013 0.0013
Schistosoma mansoni lamin 0.0028 0.0083 0.0083
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0018 0.0033 0.0511
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0083 0.0083
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0088 0.0409 0.0409
Onchocerca volvulus 0.0138 0.0677 0.0674
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0039 0.0144 0.0144
Echinococcus multilocularis glycogen phosphorylase 0.1865 1 1
Schistosoma mansoni cell adhesion molecule 0.002 0.0039 0.0039
Echinococcus granulosus lamin dm0 0.0028 0.0083 0.0083
Loa Loa (eye worm) hypothetical protein 0.0014 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0069 0.0304 0.0304
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0088 0.0409 0.0409
Schistosoma mansoni hypothetical protein 0.0032 0.0105 0.0105
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0016 0.0021 0.0305
Loa Loa (eye worm) hypothetical protein 0.0016 0.002 0.002
Echinococcus granulosus lamin 0.0028 0.0083 0.0083
Echinococcus multilocularis voltage dependent calcium channel 0.0192 0.0968 0.0968
Loa Loa (eye worm) transcription factor SMAD2 0.0118 0.0571 0.0571
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0063 0.0273 1
Brugia malayi nuclear hormone receptor 0.0042 0.0158 0.0158
Echinococcus multilocularis sodium channel protein 0.0083 0.038 0.038
Schistosoma mansoni phd finger protein 0.0012 0.0001 0.0001
Schistosoma mansoni nephrin 0.0019 0.0035 0.0035
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.0105 0.0105
Leishmania major p-glycoprotein e 0.0014 0.001 0.0232
Schistosoma mansoni multidrug resistance protein 0.0014 0.001 0.001
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0015 0.0016 0.0129
Loa Loa (eye worm) hypoxia-induced factor 1 0.0155 0.0768 0.0768
Plasmodium vivax hypothetical protein, conserved 0.0015 0.0016 0.0129
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.0117 0.0568 1
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0018 0.0033 0.0405
Loa Loa (eye worm) hypothetical protein 0.0026 0.0073 0.0073
Onchocerca volvulus Protein ultraspiracle homolog 0.0088 0.0409 0.0405
Toxoplasma gondii cytochrome p450 superfamily protein 0.0018 0.0033 0.0649
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.0105 0.0105
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0042 0.0158 0.0158
Schistosoma mansoni hypothetical protein 0.0015 0.0016 0.0016
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0093 0.0093
Brugia malayi nuclear hormone receptor family member odr-7 0.0042 0.0158 0.0158
Echinococcus multilocularis ecdysone induced protein 78C 0.0088 0.0409 0.0409
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0088 0.0409 0.0409
Plasmodium vivax cysteine repeat modular protein 2, putative 0.0015 0.0016 0.0129
Brugia malayi Hypothetical 29.7 kDa protein C05D11.5 in chromosome III 0.0021 0.0046 0.0046
Echinococcus multilocularis FTZ F1 alpha 0.0088 0.0409 0.0409
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0018 0.0033 0.0033
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0039 0.0144 0.3816
Trypanosoma brucei cytochrome P450, putative 0.0037 0.0132 0.2184
Mycobacterium ulcerans hypothetical protein 0.0021 0.0046 0.003
Loa Loa (eye worm) TK/EGFR protein kinase 0.0176 0.0885 0.0885
Onchocerca volvulus 0.0015 0.0016 0.0012
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0192 0.0968 0.0968
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0018 0.0033 0.0511
Loa Loa (eye worm) hypothetical protein 0.0042 0.0158 0.0158
Brugia malayi hypothetical protein 0.0016 0.002 0.002
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0033 0.0033
Mycobacterium ulcerans endonuclease IV 0.0079 0.0359 0.0766
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0088 0.0409 0.0409
Onchocerca volvulus 0.0244 0.1251 0.1248
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.0103 0.0103
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0063 0.0273 0.0273
Brugia malayi nuclear receptor RXR 0.0046 0.0185 0.0185
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0013 0.0004 0.0004
Brugia malayi jmjC domain containing protein 0.0016 0.0021 0.0021
Brugia malayi hypothetical protein 0.0042 0.0158 0.0158
Brugia malayi DNA-(Apurinic or apyrimidinic site) lyase 0.0079 0.0359 0.0359
Echinococcus granulosus dnaJ subfamily B 0.042 0.2201 0.2201
Mycobacterium ulcerans epimerase 0.0021 0.0046 0.003
Onchocerca volvulus 0.0037 0.0133 0.013
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.027 0.027
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0042 0.0158 0.0158
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0015 0.0016 0.0016
Loa Loa (eye worm) steroid hormone receptor 0.0088 0.0409 0.0409
Echinococcus multilocularis musashi 0.0028 0.0083 0.0083
Schistosoma mansoni tyrosine kinase 0.0058 0.0247 0.0247
Loa Loa (eye worm) hypothetical protein 0.0138 0.0677 0.0677
Schistosoma mansoni cellular tumor antigen P53 0.0051 0.0208 0.0208
Schistosoma mansoni tyrosine kinase 0.0092 0.0432 0.0432
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0133 0.0133
Brugia malayi hypoxia-induced factor 1 0.0155 0.0768 0.0768
Loa Loa (eye worm) hypothetical protein 0.0042 0.0161 0.0161
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0062 0.027 0.0559
Brugia malayi Calcitonin receptor-like protein seb-1 0.01 0.0476 0.0476
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0063 0.0273 0.0565
Echinococcus granulosus voltage dependent calcium channel 0.0192 0.0968 0.0968
Schistosoma mansoni hypothetical protein 0.0015 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0016 0.0019 0.0019
Brugia malayi follicle stimulating hormone receptor 0.0248 0.127 0.127
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0083 0.0083
Chlamydia trachomatis endonuclease IV 0.0079 0.0359 0.0355
Echinococcus multilocularis insulin receptor 0.0058 0.0247 0.0247
Brugia malayi jmjC domain containing protein 0.0062 0.0269 0.0269
Echinococcus multilocularis neuropeptide receptor A26 0.0938 0.4999 0.4999
Schistosoma mansoni nuclear receptor nhr-48 0.0042 0.0158 0.0158
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0013 0.0006 0.0006
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0088 0.0409 0.0409
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0004 0.0004
Echinococcus granulosus lysine specific demethylase 6a 0.0016 0.0021 0.0021
Brugia malayi GCC2 and GCC3 family protein 0.0015 0.0016 0.0016
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0088 0.0409 0.0409
Echinococcus granulosus ephrin type A receptor 4 A 0.0156 0.0778 0.0778
Brugia malayi MH2 domain containing protein 0.0118 0.0571 0.0571
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0039 0.0144 0.0144
Schistosoma mansoni tyrosine kinase 0.0096 0.0451 0.0451
Schistosoma mansoni jumonji/arid domain-containing protein 0.0062 0.0269 0.0269
Entamoeba histolytica hypothetical protein 0.0015 0.0016 0.0005
Entamoeba histolytica cysteine-rich surface protein, putative 0.0015 0.0016 0.0005
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0013 0.0004 0.0004
Entamoeba histolytica Flap nuclease, putative 0.0027 0.0078 0.0068
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0073 0.169
Schistosoma mansoni tyrosine kinase 0.0092 0.0432 0.0432
Mycobacterium ulcerans sugar phosphate isomerases/epimerases 0.0021 0.0046 0.003
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0192 0.0968 0.0968
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0042 0.0158 0.0158
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0015 0.0013 0.0013
Entamoeba histolytica glycogen phosphorylase, putative 0.0806 0.4286 0.428
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0016 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0046 0.0185 0.0185
Leishmania major ATP-binding cassette protein subfamily C, member 6, putative 0.0014 0.001 0.0232
Loa Loa (eye worm) cytochrome P450 family protein 0.0058 0.0244 0.0244
Brugia malayi jmjC domain containing protein 0.0016 0.0021 0.0021
Giardia lamblia Multidrug resistance-associated protein 1 0.0014 0.001 0.0001
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0088 0.0409 0.0409
Schistosoma mansoni jumonji domain containing protein 0.0016 0.0021 0.0021
Schistosoma mansoni multidrug resistance protein 0.0014 0.001 0.001
Echinococcus multilocularis thyroid hormone receptor alpha 0.0088 0.0409 0.0409
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0192 0.0968 0.0968
Loa Loa (eye worm) hypothetical protein 0.0042 0.0158 0.0158
Echinococcus granulosus epidermal growth factor receptor 0.0096 0.0451 0.0451
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0088 0.0409 0.0409
Loa Loa (eye worm) DR-78 0.0042 0.0158 0.0158
Onchocerca volvulus 0.0051 0.0208 0.0204
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0016 0.0021 0.0305
Schistosoma mansoni hypothetical protein 0.0037 0.0133 0.0133
Leishmania major protein kinase, putative 0.0018 0.0031 0.1003
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0021 0.0021
Chlamydia trachomatis glycogen phosphorylase 0.1865 1 1
Loa Loa (eye worm) calcium channel 0.0192 0.0968 0.0968
Brugia malayi Death domain containing protein 0.0015 0.0013 0.0013
Onchocerca volvulus Bile acid receptor homolog 0.0088 0.0409 0.0405
Schistosoma mansoni phosphatidylserine receptor 0.0016 0.0021 0.0021
Toxoplasma gondii aldehyde dehydrogenase 0.0062 0.027 0.7467
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0179 0.0898 0.0898
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0088 0.0409 0.0409
Loa Loa (eye worm) hypothetical protein 0.0035 0.0122 0.0122
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0016 0.0021 0.019
Onchocerca volvulus Glycogen phosphorylase homolog 0.1865 1 1
Schistosoma mansoni cpg binding protein 0.0031 0.0102 0.0102
Schistosoma mansoni phd/f-box containing protein 0.0016 0.0021 0.0021
Trichomonas vaginalis glycogen phosphorylase, putative 0.1865 1 1
Loa Loa (eye worm) flap endonuclease-1 0.0027 0.0078 0.0078
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0042 0.0158 0.0158
Echinococcus multilocularis geminin 0.0341 0.1777 0.1777
Echinococcus multilocularis Ankyrin repeat domain containing protein 0.0092 0.0432 0.0432
Leishmania major cytochrome p450-like protein 0.0018 0.0033 0.1071
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0062 0.027 0.027
Loa Loa (eye worm) hypothetical protein 0.0027 0.0081 0.0081
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0192 0.0968 0.0968
Brugia malayi Steroid receptor seven-up type 2 0.0088 0.0409 0.0409
Loa Loa (eye worm) hypothetical protein 0.01 0.0476 0.0476
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0043 0.0164 0.0164
Echinococcus multilocularis voltage dependent calcium channel 0.0192 0.0968 0.0968
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.0117 0.0568 1
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0192 0.0968 0.0968
Brugia malayi jmjC domain containing protein 0.0016 0.0021 0.0021
Loa Loa (eye worm) MH2 domain-containing protein 0.0118 0.0571 0.0571
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0062 0.027 0.9895
Trichomonas vaginalis guanylate cyclase, putative 0.0013 0.0004 0.0004
Schistosoma mansoni glycogen phosphorylase 0.1865 1 1
Brugia malayi M-phase phosphoprotein, mpp8 0.0104 0.0495 0.0495
Schistosoma mansoni hypothetical protein 0.0053 0.022 0.022
Brugia malayi tailless protein 0.0042 0.0158 0.0158
Loa Loa (eye worm) hypothetical protein 0.0014 0.0009 0.0009
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0042 0.0158 0.0158
Schistosoma mansoni jumonji domain containing protein 0.006 0.026 0.026
Brugia malayi hypothetical protein 0.0168 0.0838 0.0838
Echinococcus multilocularis ephrin type A receptor 4 A 0.0156 0.0778 0.0778
Trypanosoma cruzi multidrug resistance protein E, putative 0.0014 0.001 0.0111
Loa Loa (eye worm) hypothetical protein 0.0017 0.0026 0.0026
Loa Loa (eye worm) hypothetical protein 0.0088 0.0409 0.0409
Schistosoma mansoni hypothetical protein 0.0032 0.0105 0.0105
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0073 0.1234

Activities

Activity type Activity value Assay description Source Reference
Relative IC50 (functional) > 1000 Inhibition of LPS-induced mouse B-lymphocyte proliferation in relation to IC50 of all-trans retinoic acid. ChEMBL. 12067552

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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