Detailed information for compound 722359

Basic information

Technical information
  • TDR Targets ID: 722359
  • Name: (4-nitrophenyl)methyl 2-aminobenzoate
  • MW: 272.256 | Formula: C14H12N2O4
  • H donors: 1 H acceptors: 3 LogP: 2.97 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(c1ccccc1N)OCc1ccc(cc1)[N+](=O)[O-]
  • InChi: 1S/C14H12N2O4/c15-13-4-2-1-3-12(13)14(17)20-9-10-5-7-11(8-6-10)16(18)19/h1-8H,9,15H2
  • InChiKey: HAJJWPQZNBCOTL-UHFFFAOYSA-N  


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Synonyms

  • 2-aminobenzoic acid (4-nitrophenyl)methyl ester
  • 2-aminobenzoic acid (4-nitrobenzyl) ester
  • 4-nitrobenzyl 2-aminobenzoate
  • MLS000624941
  • SMR000293701
  • ZINC01112526

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references
Homo sapiens Rap guanine nucleotide exchange factor (GEF) 3 Starlite/ChEMBL No references
Equus caballus Ferritin light chain Starlite/ChEMBL No references
Photinus pyralis Luciferin 4-monooxygenase Starlite/ChEMBL No references
Homo sapiens breast cancer 1, early onset Starlite/ChEMBL No references
Homo sapiens RAB9A, member RAS oncogene family Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain fatty-acid CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131726 All targets in OG5_131726
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Onchocerca volvulus Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium berghei acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium knowlesi acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-coA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium falciparum acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium yoelii peroxisomal-coenzyme a synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog Get druggable targets OG5_131726 All targets in OG5_131726
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania braziliensis 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium vivax acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi N-terminal motif family protein Get druggable targets OG5_131726 All targets in OG5_131726
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 493 aa 20.7 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 480 aa 21.5 %
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase Luciferin 4-monooxygenase   550 aa 536 aa 24.4 %
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 509 aa 22.6 %
Echinococcus granulosus expressed protein Ferritin light chain   175 aa 146 aa 28.8 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 490 aa 23.3 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 505 aa 28.1 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 545 aa 24.9 %
Babesia bovis long-chain acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 445 aa 21.8 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD23 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 542 aa 23.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Toxoplasma gondii type I fatty acid synthase, putative Luciferin 4-monooxygenase   550 aa 514 aa 19.8 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 459 aa 27.0 %
Cryptosporidium parvum acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 25.7 %
Schistosoma mansoni ferritin Ferritin light chain   175 aa 171 aa 44.4 %
Schistosoma japonicum Ferritin, putative Ferritin light chain   175 aa 144 aa 24.3 %
Leishmania infantum long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Onchocerca volvulus Lysine-specific histone demethylase 1A homolog Luciferin 4-monooxygenase   550 aa 550 aa 22.5 %
Toxoplasma gondii propionate-CoA ligase Luciferin 4-monooxygenase   550 aa 550 aa 21.1 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD28 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 484 aa 20.5 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 443 aa 26.4 %
Mycobacterium leprae FATTY-ACID-CoA LIGASE FADD26 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 533 aa 22.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 499 aa 19.2 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 22.9 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE Luciferin 4-monooxygenase   550 aa 502 aa 22.5 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD34 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 537 aa 20.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 22.6 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 526 aa 22.4 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 466 aa 21.7 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 480 aa 25.2 %
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein Luciferin 4-monooxygenase   550 aa 476 aa 22.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Mycobacterium leprae PROBABLE FATTY-ACID--CoA LIGASE FADD21 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 565 aa 22.8 %
Echinococcus granulosus long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 476 aa 20.8 %
Mycobacterium ulcerans putative fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 576 aa 20.8 %
Leishmania braziliensis long-chain-fatty-acid-CoA ligase, putative Luciferin 4-monooxygenase   550 aa 504 aa 25.6 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 4, putative Luciferin 4-monooxygenase   550 aa 497 aa 23.7 %
Entamoeba histolytica acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 446 aa 22.0 %
Schistosoma mansoni apoferritin-2 Ferritin light chain   175 aa 146 aa 28.8 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 24.7 %
Echinococcus multilocularis long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 593 aa 22.1 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 544 aa 21.5 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD11 Luciferin 4-monooxygenase   550 aa 498 aa 23.5 %
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 Luciferin 4-monooxygenase   550 aa 493 aa 22.1 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 484 aa 26.0 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 507 aa 20.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 478 aa 21.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 576 aa 19.8 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 497 aa 24.7 %
Mycobacterium leprae Probable long-chain-fatty-acid-CoA ligase FadD15 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 484 aa 23.3 %
Schistosoma mansoni apoferritin-2 Ferritin light chain   175 aa 142 aa 29.6 %
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 535 aa 23.2 %
Schistosoma mansoni ferritin Ferritin light chain   175 aa 171 aa 43.9 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 494 aa 23.9 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD32 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 442 aa 23.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD29 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 617 aa 22.2 %
Dictyostelium discoideum acetyl-CoA ligase Luciferin 4-monooxygenase   550 aa 549 aa 22.2 %
Mycobacterium ulcerans non-ribosomal peptide synthetase Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF Luciferin 4-monooxygenase   550 aa 558 aa 20.1 %
Onchocerca volvulus Matrilysin homolog Luciferin 4-monooxygenase   550 aa 466 aa 24.2 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 527 aa 25.0 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 494 aa 24.3 %
Cryptosporidium parvum acetyl-coenzyme A synthetase Luciferin 4-monooxygenase   550 aa 545 aa 22.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD29 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 529 aa 22.3 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 487 aa 23.8 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 577 aa 22.2 %
Neospora caninum Short-chain dehydrogenase/reductase SDR, related Luciferin 4-monooxygenase   550 aa 518 aa 19.1 %
Trichomonas vaginalis AMP dependent ligase, putative Luciferin 4-monooxygenase   550 aa 445 aa 26.1 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 603 aa 22.6 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD32 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase). Also shown to have acyl-ACP ligase activity. Luciferin 4-monooxygenase   550 aa 487 aa 22.4 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 596 aa 21.1 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 504 aa 22.6 %
Cryptosporidium parvum putative long chain fatty acyl CoA synthetase having a signal peptide Luciferin 4-monooxygenase   550 aa 472 aa 24.8 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 550 aa 20.9 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 24.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 530 aa 23.8 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 501 aa 24.4 %
Leishmania donovani long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Loa Loa (eye worm) AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 489 aa 23.3 %
Cryptosporidium hominis acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 26.1 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.8 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD25 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 475 aa 21.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Leishmania major long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 23.2 %
Candida albicans similar to S. cerevisiae FAA4 (YMR246W) long-chain fatty acid--CoA synthetase Luciferin 4-monooxygenase   550 aa 478 aa 23.4 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 476 aa 23.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 21.7 %
Leishmania mexicana acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 559 aa 20.6 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 482 aa 24.3 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 480 aa 22.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Theileria parva long-chain fatty acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 507 aa 23.5 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase, FadD11 Luciferin 4-monooxygenase   550 aa 492 aa 24.6 %
Trypanosoma brucei fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 462 aa 23.8 %
Babesia bovis fatty acyl-CoA synthetase family protein Luciferin 4-monooxygenase   550 aa 461 aa 23.4 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 497 aa 19.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 558 aa 20.4 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.5 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD21 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 586 aa 24.4 %
Plasmodium falciparum ras-related protein Rab-5B RAB9A, member RAS oncogene family 201 aa 165 aa 30.9 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 466 aa 27.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 492 aa 23.6 %
Schistosoma mansoni FAA1 Long-chain-fatty-acid--CoA ligase 1 Luciferin 4-monooxygenase   550 aa 494 aa 26.3 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 581 aa 21.2 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 517 aa 24.8 %
Trypanosoma congolense fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 500 aa 22.4 %
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 461 aa 22.3 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Leishmania braziliensis long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 496 aa 22.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD24 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 526 aa 21.9 %
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 509 aa 21.8 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 502 aa 24.9 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 Luciferin 4-monooxygenase   550 aa 463 aa 21.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 463 aa 23.5 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 531 aa 19.0 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD26 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 560 aa 21.4 %
Neospora caninum acetyl-coenzyme a synthetase, putative Luciferin 4-monooxygenase   550 aa 549 aa 20.9 %
Leishmania mexicana long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 483 aa 23.8 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 524 aa 24.0 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 582 aa 22.3 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 601 aa 22.5 %
Trypanosoma cruzi fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 495 aa 22.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Echinococcus multilocularis expressed protein Ferritin light chain   175 aa 146 aa 30.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 452 aa 26.1 %
Cryptosporidium hominis acetyl-CoenzymeA synthetase (acetate--coa ligase) (acyl-activating enzyme) Luciferin 4-monooxygenase   550 aa 549 aa 22.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Schistosoma japonicum ko:K08745 solute carrier family 27 (fatty acid transporter), member 1, putative Luciferin 4-monooxygenase   550 aa 501 aa 24.6 %
Mycobacterium tuberculosis Probable acyl-CoA ligase FadD31 (acyl-CoA synthetase) (acyl-CoA synthase) Luciferin 4-monooxygenase   550 aa 592 aa 20.4 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis phenylalanyl-tRNA synthetase alpha chain, putative 0.0133 0.0811 0.3577
Echinococcus multilocularis 6 phosphofructokinase 0.0114 0.0687 0.2158
Onchocerca volvulus 0.0029 0.0113 0.0812
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.0243 0.0763
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0024 0.0079 0.0349
Schistosoma mansoni zinc finger protein 0.0016 0.0028 0.0124
Entamoeba histolytica hypothetical protein 0.0043 0.0212 0.0936
Schistosoma mansoni sex comb on midleg homolog 0.005 0.0257 0.1132
Wolbachia endosymbiont of Brugia malayi phenylalanyl-tRNA synthetase subunit beta 0.0037 0.0169 0.0169
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0031 0.0127 0.0561
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0024 0.0079 0.0249
Schistosoma mansoni phenylalanyl-tRNA synthetase mitochondrial 0.0233 0.1489 0.6565
Schistosoma mansoni sex comb on midleg homolog 0.005 0.0257 0.1132
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.005 0.0257 0.1132
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0113 0.0496
Schistosoma mansoni hypothetical protein 0.0016 0.0028 0.0124
Treponema pallidum phenylalanyl-tRNA synthetase subunit alpha 0.0349 0.2269 1
Loa Loa (eye worm) phenylalanyl-tRNA synthetase 0.0233 0.1489 0.6565
Loa Loa (eye worm) hypothetical protein 0.0043 0.0208 0.0915
Plasmodium vivax phenylalanine--tRNA ligase, putative 0.0133 0.0811 0.3577
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.005 0.0257 0.1852
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0057 0.0303 0.0953
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0127 0.0561
Entamoeba histolytica acyl-coA synthetase, putative 0.0029 0.0113 0.0496
Trypanosoma cruzi ISWI complex protein 0.0016 0.0028 0.0124
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0113 0.0377
Echinococcus multilocularis SAM and MBT domain containing protein 0.005 0.0257 0.0806
Brugia malayi N-terminal motif family protein 0.0218 0.1386 0.6111
Loa Loa (eye worm) hypothetical protein 0.004 0.0191 0.0841
Echinococcus multilocularis neuropeptide s receptor 0.0485 0.3184 1
Loa Loa (eye worm) mbt repeat family protein 0.005 0.0257 0.1132
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0212 0.0667
Loa Loa (eye worm) bromodomain containing protein 0.0019 0.0045 0.0197
Entamoeba histolytica phenylalanyl-tRNA synthetase alpha subunit, putative 0.0349 0.2269 1
Echinococcus multilocularis phenylalanyl tRNA synthetase alpha chain B 0.0349 0.2269 0.7124
Schistosoma mansoni myelin transcription factor 1 myt1 0.0057 0.0303 0.1337
Echinococcus granulosus neuropeptide receptor A26 0.0485 0.3184 1
Plasmodium falciparum phenylalanine--tRNA ligase alpha subunit 0.0349 0.2269 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0113 0.0377
Echinococcus multilocularis histone acetyltransferase MYST2 0.0057 0.0303 0.0953
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0031 0.0127 0.0561
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0048 0.0243 0.1071
Trichomonas vaginalis phosphofructokinase, putative 0.0114 0.0687 0.303
Schistosoma mansoni phenylalanyl-tRNA synthetase subunit alpha 0.0133 0.0811 0.3577
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.0113 0.0818
Schistosoma mansoni 6-phosphofructokinase 0.0114 0.0687 0.303
Schistosoma mansoni bromodomain containing protein 0.0066 0.0367 0.1617
Chlamydia trachomatis phenylalanine--tRNA ligase subunit beta 0.0037 0.0169 0.0169
Trichomonas vaginalis phosphofructokinase, putative 0.0114 0.0687 0.303
Entamoeba histolytica hypothetical protein 0.0043 0.0212 0.0936
Loa Loa (eye worm) hypothetical protein 0.0029 0.0113 0.0496
Echinococcus granulosus histone lysine methyltransferase setb 0.0018 0.004 0.0127
Toxoplasma gondii Ferredoxin-fold anticodon binding domain-containing protein 0.0233 0.1489 0.6565
Schistosoma mansoni 6-phosphofructokinase 0.0114 0.0687 0.303
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0114 0.0687 0.303
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0197 0.1247 0.3916
Plasmodium vivax phenylalanine--tRNA ligase, putative 0.0233 0.1489 0.6565
Schistosoma mansoni hypothetical protein 0.0022 0.0066 0.029
Wolbachia endosymbiont of Brugia malayi phenylalanyl-tRNA synthetase subunit alpha 0.1499 1 1
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0113 0.0496
Brugia malayi phosphofructokinase 0.0114 0.0687 0.303
Trypanosoma cruzi phenylalanyl-tRNA synthetase alpha chain, putative 0.0349 0.2269 1
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0038 0.0174 0.0545
Loa Loa (eye worm) hypothetical protein 0.0074 0.0419 0.1848
Trypanosoma cruzi ISWI complex protein 0.0016 0.0028 0.0124
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0113 0.0377
Loa Loa (eye worm) hypothetical protein 0.0021 0.0064 0.0282
Loa Loa (eye worm) MBCTL1 0.0057 0.0303 0.1337
Giardia lamblia Phenylalanyl-tRNA synthetase alpha chain 0.0349 0.2269 1
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0057 0.0303 0.0953
Loa Loa (eye worm) 6-phosphofructokinase 0.0114 0.0687 0.303
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0114 0.0687 0.0635
Echinococcus multilocularis zinc finger protein 0.0021 0.0058 0.0183
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0114 0.0687 0.303
Leishmania major phenylalanyl-tRNA synthetase alpha chain, putative 0.0349 0.2269 1
Brugia malayi mbt repeat family protein 0.005 0.0257 0.1132
Trichomonas vaginalis phosphofructokinase, putative 0.0114 0.0687 0.303
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0057 0.0303 0.1337
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0197 0.1247 0.3916
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0031 0.0127 0.0127
Loa Loa (eye worm) hypothetical protein 0.0021 0.0064 0.0282
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0127 0.0561
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.004 0.0178
Mycobacterium ulcerans phenylalanyl-tRNA synthetase subunit beta 0.0037 0.0169 0.0169
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0021 0.0064 0.0064
Schistosoma mansoni phenylalanyl-tRNA synthetase subunit alpha 0.0349 0.2269 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0018 0.004 0.0178
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0212 0.0667
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0114 0.0687 0.4991
Brugia malayi hypothetical protein 0.0043 0.0212 0.0936
Plasmodium vivax phenylalanine--tRNA ligase alpha subunit, putative 0.0349 0.2269 1
Loa Loa (eye worm) hypothetical protein 0.0349 0.2269 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0243 0.1071
Echinococcus granulosus methyl CpG binding domain protein 2 0.0018 0.004 0.0127
Plasmodium vivax acyl-CoA synthetase, putative 0.0021 0.0064 0.0282
Plasmodium vivax 6-phosphofructokinase, putative 0.0031 0.0127 0.0561
Trichomonas vaginalis phosphofructokinase, putative 0.0114 0.0687 0.303
Mycobacterium ulcerans phenylalanyl-tRNA synthetase subunit alpha 0.1499 1 1
Echinococcus multilocularis polycomb protein SCMH1 0.005 0.0257 0.0806
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0127 0.0561
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0218 0.1386 1
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0127 0.0561
Schistosoma mansoni hypothetical protein 0.0043 0.0212 0.0936
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0029 0.0113 0.0113
Echinococcus granulosus histone acetyltransferase MYST2 0.0057 0.0303 0.0953
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0113 0.0496
Plasmodium falciparum phenylalanine--tRNA ligase 0.0233 0.1489 0.6565
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0127 0.0561
Plasmodium falciparum phenylalanine--tRNA ligase 0.017 0.106 0.4674
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0031 0.0127 0.0561
Plasmodium vivax 6-phosphofructokinase, putative 0.0031 0.0127 0.0561
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0113 0.0113
Entamoeba histolytica hypothetical protein 0.0043 0.0212 0.0936
Loa Loa (eye worm) 6-phosphofructokinase 0.0114 0.0687 0.303
Loa Loa (eye worm) hypothetical protein 0.005 0.0257 0.1132
Brugia malayi PHD-finger family protein 0.0026 0.0096 0.0423
Trichomonas vaginalis phenylalanyl-tRNA synthetase alpha chain, putative 0.0133 0.0811 0.3577
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0114 0.0687 0.303
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.0243 0.0763
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0113 0.0113
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0029 0.0113 0.0113
Loa Loa (eye worm) hypothetical protein 0.0045 0.0221 0.0975
Onchocerca volvulus 0.005 0.0257 0.1852
Entamoeba histolytica phosphofructokinase, putative 0.0114 0.0687 0.303
Echinococcus granulosus fetal alzheimer antigen falz 0.0024 0.0079 0.0249
Trypanosoma brucei phenylalanyl-tRNA synthetase alpha chain, putative 0.0349 0.2269 1
Toxoplasma gondii phosphofructokinase PFKII 0.0031 0.0127 0.0561
Toxoplasma gondii 6-phosphofructokinase 0.0031 0.0127 0.0561
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0243 0.1071
Echinococcus granulosus polycomb protein SCMH1 0.005 0.0257 0.0806
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0063 0.0341 0.1072
Mycobacterium tuberculosis Probable phenylalanyl-tRNA synthetase, beta chain PheT 0.0037 0.0169 0.0113
Echinococcus granulosus 6 phosphofructokinase 0.0114 0.0687 0.2158
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0021 0.0064 0.0064
Loa Loa (eye worm) phosphofructokinase 0.0114 0.0687 0.303
Echinococcus granulosus SAM and MBT domain containing protein 0.005 0.0257 0.0806
Echinococcus granulosus phenylalanyl tRNA synthetase 0.0233 0.1489 0.4677
Brugia malayi 6-phosphofructokinase 0.0114 0.0687 0.303
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0031 0.0127 0.0127
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0031 0.0127 0.0561
Brugia malayi phenylalanyl-tRNA synthetase, mitochondrial precursor, putative 0.0233 0.1489 0.6565
Brugia malayi mbt repeat family protein 0.005 0.0257 0.1132
Echinococcus granulosus zinc finger protein 0.0021 0.0058 0.0183
Schistosoma mansoni zinc finger protein 0.0021 0.0058 0.0257
Entamoeba histolytica phosphofructokinase, putative 0.0114 0.0687 0.303
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.0113 0.0818
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0212 0.0936
Echinococcus multilocularis phenylalanyl tRNA synthetase 0.0233 0.1489 0.4677
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0048 0.0243 0.1071
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0029 0.0113 0.0113
Loa Loa (eye worm) hypothetical protein 0.0029 0.0113 0.0496
Mycobacterium ulcerans hypothetical protein 0.0029 0.0113 0.0113
Leishmania major ATP-dependent phosphofructokinase 0.0114 0.0687 0.2943
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0063 0.0341 0.1072
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0018 0.004 0.0127
Mycobacterium leprae Probable phenylalanyl-tRNA synthetase, alpha chain PheS 0.0217 0.1377 1
Echinococcus granulosus phenylalanyl tRNA synthetase alpha chain B 0.0349 0.2269 0.7124
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0031 0.0127 0.0561
Brugia malayi Bromodomain containing protein 0.004 0.019 0.0839
Brugia malayi Bromodomain containing protein 0.0079 0.0449 0.1981
Schistosoma mansoni hypothetical protein 0.0304 0.1967 0.867
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.0113 0.0057
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0029 0.0113 0.0113
Loa Loa (eye worm) hypothetical protein 0.0021 0.0064 0.0282
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0018 0.004 0.0127
Mycobacterium tuberculosis Probable phenylalanyl-tRNA synthetase, alpha chain PheS 0.1499 1 1
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0113 0.0496
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0018 0.004 0.0178
Brugia malayi 6-phosphofructokinase 0.0114 0.0687 0.303
Echinococcus multilocularis neuropeptide receptor A26 0.0485 0.3184 1
Trypanosoma brucei ISWI complex protein 0.0016 0.0028 0.0124
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0127 0.0561
Trichomonas vaginalis phenylalanyl-tRNA synthetase alpha chain, putative 0.0349 0.2269 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.0243 0.0763
Entamoeba histolytica hypothetical protein 0.0043 0.0212 0.0936
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0113 0.0113
Loa Loa (eye worm) hypothetical protein 0.0057 0.0303 0.1337
Entamoeba histolytica phosphofructokinase, putative 0.0114 0.0687 0.303
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0038 0.0174 0.0545
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0243 0.1071
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0031 0.0127 0.0561
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0021 0.0064 0.0008
Loa Loa (eye worm) hypothetical protein 0.0018 0.004 0.0178
Brugia malayi phenylalanyl (f) trna synthetase protein 1 0.0349 0.2269 1
Mycobacterium ulcerans 6-phosphofructokinase 0.0114 0.0687 0.0687
Plasmodium falciparum acyl-CoA synthetase 0.0021 0.0064 0.0282
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.0243 0.0763
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.004 0.0178
Loa Loa (eye worm) PHD-finger family protein 0.0022 0.0066 0.029
Toxoplasma gondii phenylalanyl-tRNA synthetase alpha chain A, putative 0.0349 0.2269 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0113 0.0496
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0113 0.0496
Loa Loa (eye worm) hypothetical protein 0.0021 0.0064 0.0282
Echinococcus granulosus neuropeptide s receptor 0.0485 0.3184 1
Loa Loa (eye worm) hypothetical protein 0.0218 0.1386 0.6111
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0031 0.0127 0.0561
Loa Loa (eye worm) hypothetical protein 0.0021 0.0064 0.0282
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0029 0.0113 0.0057

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 3.1623 uM PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 3 (EPAC1): primary screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 3.9811 um PUBCHEM_BIOASSAY: qHTS Assay for Rab9 Promoter Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.5821 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 12.5893 uM PubChem BioAssay. qHTS Assay to Identify Small Molecule Activators of BRCA1 Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 13.1154 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 13.4591 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (binding) = 14.1254 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference
Potency (functional) 20.5878 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that induce genotoxicity in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493106, AID493143] ChEMBL. No reference
Potency (functional) 20.5878 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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