Detailed information for compound 724491

Basic information

Technical information
  • TDR Targets ID: 724491
  • Name: N-(3-acetylphenyl)-2-[(2,4-dichlorophenyl)-me thylsulfonylamino]acetamide
  • MW: 415.291 | Formula: C17H16Cl2N2O4S
  • H donors: 1 H acceptors: 4 LogP: 2.91 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(CN(S(=O)(=O)C)c1ccc(cc1Cl)Cl)Nc1cccc(c1)C(=O)C
  • InChi: 1S/C17H16Cl2N2O4S/c1-11(22)12-4-3-5-14(8-12)20-17(23)10-21(26(2,24)25)16-7-6-13(18)9-15(16)19/h3-9H,10H2,1-2H3,(H,20,23)
  • InChiKey: QQGMOULOVGZNBF-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(3-acetylphenyl)-2-[(2,4-dichlorophenyl)-methylsulfonyl-amino]acetamide
  • N-(3-acetylphenyl)-2-[(2,4-dichlorophenyl)-mesyl-amino]acetamide
  • 2-[(2,4-dichlorophenyl)-methylsulfonyl-amino]-N-(3-ethanoylphenyl)ethanamide
  • ZINC02871288

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium falciparum phosphoglycerate kinase 0.0169 0.2172 0.7639
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0358 0.0412
Loa Loa (eye worm) hypothetical protein 0.0169 0.2172 0.2542
Trichomonas vaginalis Citrate lyase beta chain, putative 0.0048 0.05 0.0579
Echinococcus multilocularis lysine specific demethylase 5A 0.0075 0.0873 0.0868
Loa Loa (eye worm) transcriptional regulator 0.063 0.8544 1
Echinococcus multilocularis tar DNA binding protein 0.0062 0.0699 0.0693
Entamoeba histolytica hypothetical protein 0.0038 0.0358 0.0412
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0307 0.0352
Brugia malayi transcriptional regulator, Sir2 family protein 0.063 0.8544 1
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.0034 0.0307 0.1078
Trichomonas vaginalis chromobox protein, putative 0.0034 0.0307 0.0352
Plasmodium falciparum type II NADH:ubiquinone oxidoreductase 0.0017 0.0072 0.0253
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0699 0.0751
Plasmodium falciparum transcriptional regulatory protein sir2a 0.0218 0.2843 1
Leishmania major phosphoglycerate kinase B, cytosolic 0.0169 0.2172 0.2542
Leishmania major DNA polymerase eta, putative 0.0064 0.0715 0.0837
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0023 0.0157 0.0403
Loa Loa (eye worm) glutaminase 0.0271 0.3588 0.42
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0066 0.0742 0.0862
Schistosoma mansoni serine/threonine protein kinase 0.0039 0.0374 0.0402
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0039 0.0374 0.0438
Loa Loa (eye worm) MH2 domain-containing protein 0.0119 0.1474 0.1726
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0066 0.0742 0.0868
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0017 0.0072 0.0084
Plasmodium vivax hypothetical protein, conserved 0.0149 0.1895 0.6666
Loa Loa (eye worm) sirtuin 4 0.0149 0.1895 0.2218
Onchocerca volvulus 0.0089 0.1067 0.2009
Echinococcus multilocularis phd:f box containing protein 0.002 0.0112 0.0106
Trypanosoma cruzi hypothetical protein, conserved 0.0418 0.5608 0.6563
Brugia malayi jmjC domain containing protein 0.002 0.0112 0.0131
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0064 0.0726 0.2555
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0041 0.0396 0.0457
Trypanosoma brucei DNA polymerase IV, putative 0.0038 0.0365 0.0428
Trichomonas vaginalis DNA helicase recq, putative 0.0013 0.0012 0.0007
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0017 0.0072 0.0066
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0039 0.0374 0.0438
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0034 0.0307 0.0329
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0472 0.6353 1
Loa Loa (eye worm) programmed cell death 8 0.0017 0.0072 0.0084
Schistosoma mansoni chromobox protein 0.0034 0.0307 0.0329
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0083 0.0977 0.1143
Leishmania major 2,4-dienoyl-coa reductase fadh1, putative 0.0017 0.0072 0.0084
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.063 0.8544 1
Brugia malayi TAR-binding protein 0.0062 0.0699 0.0818
Trichomonas vaginalis DNA helicase recq1, putative 0.0024 0.0165 0.0186
Mycobacterium ulcerans phosphoglycerate kinase 0.0169 0.2172 0.6053
Trichomonas vaginalis DNA polymerase eta, putative 0.0038 0.0365 0.0421
Mycobacterium ulcerans hypothetical protein 0.0048 0.05 0.1394
Leishmania major 2,4-dienoyl-coa reductase-like protein 0.0017 0.0072 0.0084
Schistosoma mansoni z-protein (S1r protein) 0.0038 0.0358 0.0384
Leishmania major DNA polymerase kappa, putative 0.0038 0.0365 0.0428
Schistosoma mansoni regulator of G protein signaling 0.0038 0.0358 0.0384
Trichomonas vaginalis CAMK family protein kinase 0.0186 0.2404 0.2809
Giardia lamblia Thioredoxin reductase 0.0017 0.0072 0.0084
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0062 0.0693 0.0811
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.0699 0.0818
Loa Loa (eye worm) hypothetical protein 0.0038 0.0358 0.0418
Echinococcus multilocularis chromobox protein 1 0.0208 0.2713 0.2709
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0354 0.0408
Brugia malayi M-phase phosphoprotein, mpp8 0.0034 0.0307 0.0359
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0038 0.0358 0.0412
Echinococcus granulosus lysine specific demethylase 6a 0.002 0.0112 0.0106
Plasmodium falciparum thioredoxin reductase 0.0186 0.2406 0.8463
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.002 0.0112 0.0395
Loa Loa (eye worm) hypothetical protein 0.0089 0.1067 0.1249
Trichomonas vaginalis chromobox protein, putative 0.0126 0.1571 0.1833
Brugia malayi Regulator of G protein signaling domain containing protein 0.0038 0.0358 0.0418
Trypanosoma brucei phosphoglycerate kinase 0.0169 0.2172 0.2542
Echinococcus multilocularis thioredoxin glutathione reductase 0.0186 0.2413 0.2408
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0365 0.0428
Trichomonas vaginalis CAMK family protein kinase 0.0186 0.2404 0.2809
Echinococcus granulosus thioredoxin glutathione reductase 0.0186 0.2413 0.2408
Echinococcus multilocularis glutamate synthase 0.0017 0.0072 0.0066
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0066 0.0742 0.0868
Giardia lamblia Nuclear LIM interactor-interacting factor 1 0.0012 0.0006 0.0007
Brugia malayi jmjC domain containing protein 0.002 0.0112 0.0131
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0017 0.0072 0.0077
Onchocerca volvulus 0.0091 0.11 0.2076
Schistosoma mansoni hypothetical protein 0.0062 0.0693 0.0744
Echinococcus multilocularis L aminoadipate semialdehyde 0.0083 0.0977 0.0972
Brugia malayi PXA domain containing protein 0.0038 0.0358 0.0418
Plasmodium vivax hypothetical protein, conserved 0.0062 0.0693 0.2437
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0365 0.0428
Entamoeba histolytica hypothetical protein 0.0034 0.0307 0.0352
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0041 0.0396 0.0457
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0064 0.0726 0.085
Plasmodium falciparum heterochromatin protein 1 0.0034 0.0307 0.1078
Leishmania major NADH dehydrogenase, putative 0.0017 0.0072 0.0084
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0048 0.05 0.1394
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0023 0.0157 0.0135
Giardia lamblia PHD finger protein 15 0.0062 0.0693 0.0811
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0365 0.0428
Loa Loa (eye worm) hypothetical protein 0.0038 0.0358 0.0418
Echinococcus granulosus lysine specific demethylase 5A 0.0077 0.0896 0.089
Trypanosoma cruzi DNA polymerase eta, putative 0.0064 0.0715 0.0837
Trichomonas vaginalis conserved hypothetical protein 0.0083 0.0978 0.1138
Plasmodium vivax heterochromatin protein 1, putative 0.0034 0.0307 0.1078
Echinococcus multilocularis NAD dependent deacetylase sirtuin 6 0.0149 0.1895 0.189
Schistosoma mansoni regulator of G protein signaling 0.0038 0.0358 0.0384
Schistosoma mansoni DNA polymerase eta 0.0064 0.0715 0.0768
Mycobacterium tuberculosis Transcriptional regulatory protein 0.0218 0.2843 0.4412
Entamoeba histolytica serine/threonine protein kinase, putative 0.0375 0.5024 0.5878
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0062 0.0693 0.0811
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0424 0.5699 0.8958
Entamoeba histolytica hypothetical protein 0.0036 0.0329 0.0379
Echinococcus multilocularis transcription factor Dp 1 0.0038 0.036 0.0354
Echinococcus multilocularis microtubule associated protein 2 0.0685 0.9308 0.9308
Echinococcus granulosus chromobox protein 1 0.0208 0.2713 0.2709
Toxoplasma gondii histone deacetylase SIR2 0.0218 0.2843 1
Toxoplasma gondii histone lysine demethylase JMJD6a 0.002 0.0112 0.0395
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0218 0.2843 0.3323
Schistosoma mansoni terminal deoxycytidyl transferase 0.0038 0.0365 0.0393
Loa Loa (eye worm) hypothetical protein 0.0017 0.0072 0.0084
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0064 0.0726 0.2555
Loa Loa (eye worm) thioredoxin reductase 0.0186 0.2406 0.2816
Loa Loa (eye worm) transcriptional regulator 0.0149 0.1895 0.2218
Trichomonas vaginalis chromobox protein, putative 0.0208 0.2713 0.3171
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.006 0.0669 0.0951
Toxoplasma gondii thioredoxin reductase 0.0186 0.2406 0.8463
Trypanosoma brucei unspecified product 0.0026 0.0201 0.0235
Trypanosoma cruzi NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0017 0.0072 0.0084
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0064 0.0726 0.2555
Trypanosoma brucei DNA polymerase IV, putative 0.0038 0.0365 0.0428
Brugia malayi NAD-dependent deacetylase SIRT1 0.0371 0.4967 0.5813
Plasmodium vivax type II NADH:ubiquinone oxidoreductase, putative 0.0017 0.0072 0.0253
Toxoplasma gondii chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 0.0034 0.0307 0.1078
Trichomonas vaginalis CAMK family protein kinase 0.0375 0.5024 0.5878
Schistosoma mansoni axis inhibition protein axin 0.0038 0.0358 0.0384
Mycobacterium ulcerans glutaminase 0.0271 0.3588 1
Mycobacterium ulcerans citrate lyase beta subunit, CitE_2 0.0048 0.05 0.1394
Brugia malayi serine/threonine-protein kinase plk-2 0.0375 0.5024 0.5881
Giardia lamblia NAD-dependent histone deacetylase Sir2 0.0371 0.4967 0.5813
Brugia malayi Valyl-tRNA synthetase 0.0034 0.0307 0.0359
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0064 0.0726 0.085
Plasmodium vivax phosphoglycerate kinase, putative 0.0169 0.2172 0.7639
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0699 0.0751
Trichomonas vaginalis chromobox protein, putative 0.0034 0.0307 0.0352
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0089 0.1067 0.1249
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0017 0.0072 0.0084
Onchocerca volvulus 0.0034 0.0307 0.0474
Mycobacterium ulcerans thioredoxin reductase TrxB2 0.0017 0.0072 0.0201
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0064 0.0726 0.085
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0064 0.0726 0.3116
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0017 0.0072 0.0077
Mycobacterium tuberculosis Conserved protein 0.0048 0.05 0.0682
Mycobacterium tuberculosis Probable reductase 0.0424 0.5699 0.8958
Echinococcus granulosus regulator of G protein signaling 7 0.0038 0.0358 0.0352
Entamoeba histolytica hypothetical protein 0.0036 0.0329 0.0379
Echinococcus granulosus regulator of G protein signaling 3 0.0038 0.0358 0.0352
Loa Loa (eye worm) glutathione reductase 0.0186 0.2406 0.2816
Brugia malayi Bloom's syndrome protein homolog 0.0024 0.0165 0.0193
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0034 0.0307 0.0301
Schistosoma mansoni cpg binding protein 0.003 0.0252 0.0271
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0358 0.0412
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0699 0.0751
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0066 0.0742 0.0868
Loa Loa (eye worm) hypothetical protein 0.0106 0.1305 0.1528
Trichomonas vaginalis chromobox protein, putative 0.0208 0.2713 0.3171
Mycobacterium ulcerans monoxygenase 0.0017 0.0072 0.0201
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0034 0.0307 0.0352
Trichomonas vaginalis apoptosis inducing factor, putative 0.0017 0.0072 0.0077
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0064 0.0726 0.085
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0062 0.0693 0.0811
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0038 0.0365 0.036
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0424 0.5699 0.8958
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0017 0.0072 0.0077
Mycobacterium ulcerans NADH dehydrogenase Ndh1 0.0017 0.0072 0.0201
Echinococcus multilocularis axis inhibition protein axin 0.0038 0.0358 0.0352
Echinococcus multilocularis jumonji domain containing protein 0.0086 0.1029 0.1023
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0375 0.5024 0.5021
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0064 0.0726 0.085
Echinococcus multilocularis regulator of G protein signaling 7 0.0038 0.0358 0.0352
Loa Loa (eye worm) transcriptional regulator 0.0149 0.1895 0.2218
Schistosoma mansoni hypothetical protein 0.0034 0.0307 0.0329
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0064 0.0726 0.085
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0035 0.0315 0.0339
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0064 0.0726 0.085
Trypanosoma cruzi trypanothione reductase, putative 0.0064 0.0726 0.085
Giardia lamblia Phosphoglycerate kinase 0.0169 0.2172 0.2542
Echinococcus granulosus glutamate synthase 0.0017 0.0072 0.0066
Trypanosoma brucei NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0017 0.0072 0.0084
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0038 0.0365 0.036
Leishmania major trypanothione reductase 0.0186 0.2406 0.2816
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0017 0.0072 0.0084
Plasmodium vivax ferrodoxin reductase, putative 0.0017 0.0072 0.0253
Loa Loa (eye worm) hypothetical protein 0.0034 0.0307 0.0359
Schistosoma mansoni disulfide oxidoreductase 0.0017 0.0072 0.0077
Echinococcus multilocularis regulator of G protein signaling 7 0.0038 0.0358 0.0352
Mycobacterium leprae Probable NAD-dependent deacetylase NpdA (Regulatory protein SIR2 homolog) 0.0069 0.0784 0.1133
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0371 0.4967 0.5811
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0017 0.0072 0.0066
Schistosoma mansoni nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) 0.0012 0.0006 0.0006
Schistosoma mansoni axis inhibition protein axin 0.0038 0.0358 0.0384
Onchocerca volvulus 0.0089 0.1067 0.2009
Echinococcus multilocularis NAD dependent deacetylase sirtuin 1 0.0371 0.4967 0.4964
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.063 0.8544 1
Leishmania major hypothetical protein, conserved 0.0017 0.0072 0.0084
Trichomonas vaginalis CAMK family protein kinase 0.0375 0.5024 0.5878
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0038 0.0354 0.0408
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0699 0.0751
Echinococcus granulosus bloom syndrome protein 0.0024 0.0165 0.0159
Treponema pallidum phosphoglycerate kinase 0.0169 0.2172 1
Loa Loa (eye worm) PXA domain-containing protein 0.0038 0.0358 0.0418
Trypanosoma brucei DNA polymerase IV, putative 0.0038 0.0365 0.0428
Plasmodium vivax hypothetical protein, conserved 0.0034 0.0307 0.1078
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0023 0.0157 0.0551
Loa Loa (eye worm) RecQ helicase 0.0024 0.0165 0.0193
Echinococcus multilocularis chromobox protein 2 0.0034 0.0307 0.0301
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0307 0.0352
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0307 0.0352
Brugia malayi hypothetical protein 0.0034 0.0307 0.0359
Plasmodium falciparum phd finger protein, putative 0.0062 0.0693 0.2437
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0669 0.0719
Brugia malayi Carboxy-terminal domain RNA polymerase II polypeptide A smallphosphatase 1 0.0012 0.0006 0.0007
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0022 0.0135 0.0129
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0066 0.0742 0.0797
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0034 0.0307 0.0352
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0017 0.0072 0.0077
Echinococcus multilocularis regulator of G protein signaling 0.0038 0.0358 0.0352
Echinococcus granulosus dna polymerase eta 0.0064 0.0715 0.071
Entamoeba histolytica hypothetical protein 0.0023 0.0157 0.0176
Leishmania major NAD dependent deacetylase, putative,transcriptional regulator, Sir2 family protein, nicotinic acid mononucleotide 5,6-dimethylbe 0.0218 0.2843 0.3328
Trichomonas vaginalis chromobox protein, putative 0.0126 0.1571 0.1833
Trypanosoma cruzi hypothetical protein, conserved 0.0017 0.0072 0.0084
Onchocerca volvulus 0.0089 0.1067 0.2009
Schistosoma mansoni chromobox protein 0.0208 0.2713 0.2915
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0169 0.2172 0.2537
Echinococcus granulosus chromobox protein 1 0.0208 0.2713 0.2709
Loa Loa (eye worm) hypothetical protein 0.0038 0.0358 0.0418
Loa Loa (eye worm) heterochromatin protein 1 0.0208 0.2713 0.3176
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0064 0.0726 0.0721
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0064 0.0726 0.078
Toxoplasma gondii PHD-finger domain-containing protein 0.0062 0.0693 0.2437
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0017 0.0072 0.0066
Schistosoma mansoni chromobox protein 0.0208 0.2713 0.2915
Entamoeba histolytica phosphoglycerate kinase, putative 0.0169 0.2172 0.2537
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0038 0.0365 0.0421
Mycobacterium tuberculosis Conserved hypothetical protein 0.0038 0.0365 0.0467
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0036 0.0329 0.0323
Schistosoma mansoni phosphoglycerate kinase 0.0169 0.2172 0.2333
Mycobacterium ulcerans NADH dehydrogenase Ndh 0.0017 0.0072 0.0201
Toxoplasma gondii Dullard family phosphatase domain-containing protein 0.0012 0.0006 0.0021
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0034 0.0307 0.0329
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0064 0.0726 0.085
Loa Loa (eye worm) hypothetical protein 0.002 0.0112 0.0131
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0062 0.0693 0.0811
Trypanosoma brucei phosphoglycerate kinase 0.0169 0.2172 0.2542
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0358 0.0412
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0169 0.2172 0.2542
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.002 0.0116 0.0407
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0669 0.0719
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0017 0.0072 0.0084
Brugia malayi RNA binding protein 0.0062 0.0699 0.0818
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0017 0.0072 0.0077
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0307 0.0352
Echinococcus granulosus NAD dependent deacetylase sirtuin 7 0.0149 0.1895 0.189
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0038 0.0358 0.0384
Plasmodium falciparum NLI interacting factor-like phosphatase, putative 0.0012 0.0006 0.0021
Trypanosoma brucei DNA polymerase kappa, putative 0.0026 0.0201 0.0235
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0064 0.0726 0.2555
Trichomonas vaginalis CAMK family protein kinase 0.0375 0.5024 0.5878
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0013 0.0012 0.0014
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0203 0.2643 0.2639
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0064 0.0726 0.085
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0064 0.0726 0.085
Entamoeba histolytica hypothetical protein 0.0036 0.0329 0.0379
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0023 0.0157 0.0436
Loa Loa (eye worm) PHD-finger family protein 0.0062 0.0693 0.0811
Loa Loa (eye worm) jmjC domain-containing protein 0.0128 0.1606 0.1879
Toxoplasma gondii phosphoglycerate kinase PGKII 0.0169 0.2172 0.7639
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0017 0.0072 0.0066
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0089 0.1067 0.1249
Trichomonas vaginalis glutaminase, putative 0.0271 0.3588 0.4196
Trypanosoma brucei unspecified product 0.0026 0.0201 0.0235
Brugia malayi Regulator of G protein signaling domain containing protein 0.0038 0.0358 0.0418
Schistosoma mansoni glutamate synthase 0.0017 0.0072 0.0077
Loa Loa (eye worm) jmjC domain-containing protein 0.002 0.0112 0.0131
Echinococcus multilocularis lysine specific demethylase 6a 0.002 0.0112 0.0106
Giardia lamblia Kinase, PLK 0.0375 0.5024 0.5881
Mycobacterium leprae conserved hypothetical protein 0.0023 0.0157 0.0135
Echinococcus granulosus phosphoglycerate kinase 1 0.0169 0.2172 0.2167
Loa Loa (eye worm) hypothetical protein 0.0034 0.0307 0.0359
Brugia malayi transcriptional regulator, Sir2 family protein 0.0149 0.1895 0.2218
Loa Loa (eye worm) hypothetical protein 0.0038 0.0358 0.0418
Echinococcus multilocularis bloom syndrome protein 0.0024 0.0165 0.0159
Schistosoma mansoni serine/threonine protein kinase 0.0039 0.0374 0.0402
Trypanosoma cruzi DNA polymerase kappa, putative 0.0038 0.0365 0.0428
Schistosoma mansoni chromatin regulatory protein sir2 0.0149 0.1895 0.2036
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0017 0.0072 0.0077
Echinococcus multilocularis axis inhibition protein axin 0.0038 0.0358 0.0352
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0066 0.0742 0.0736
Brugia malayi A-kinase anchor protein 10, precursor 0.0038 0.0358 0.0418
Trypanosoma cruzi NADH dehydrogenase, putative 0.0017 0.0072 0.0084
Toxoplasma gondii non-proton pumping type-II NADH dehydrogenase I 0.0017 0.0072 0.0253
Schistosoma mansoni microtubule-associated protein tau 0.0685 0.9308 1
Toxoplasma gondii histone deacetylase SIR2-like 0.0149 0.1895 0.6666
Echinococcus granulosus microtubule associated protein 2 0.0685 0.9308 0.9308
Plasmodium vivax thioredoxin reductase, putative 0.0186 0.2406 0.8463
Trichomonas vaginalis CAMK family protein kinase 0.0375 0.5024 0.5878
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0066 0.0742 0.0868
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0218 0.2843 0.3323
Schistosoma mansoni glutaminase 0.0271 0.3588 0.3855
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.0699 0.0818
Leishmania major hypothetical protein, conserved 0.0418 0.5608 0.6563
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0017 0.0072 0.0066
Trypanosoma brucei DNA polymerase eta, putative 0.0064 0.0715 0.0837
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0017 0.0072 0.0084
Echinococcus multilocularis dna polymerase kappa 0.0038 0.0365 0.036
Echinococcus multilocularis peregrin 0.0062 0.0693 0.0687
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.0017 0.0072 0.0077
Brugia malayi jmjC domain containing protein 0.0203 0.2643 0.3094
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0038 0.0365 0.0393
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0307 0.0352
Schistosoma mansoni chromatin regulatory protein sir2 0.0218 0.2843 0.3054
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0038 0.0365 0.0428
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0038 0.0365 0.0428
Toxoplasma gondii PHD-finger domain-containing protein 0.0062 0.0693 0.2437
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0307 0.0352
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0017 0.0072 0.0253
Giardia lamblia DINP protein human, muc B family 0.0038 0.0365 0.0428
Brugia malayi Common central domain of tyrosinase family protein 0.0089 0.1067 0.1249
Echinococcus granulosus Chromo domain 0.0034 0.0307 0.0301
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0064 0.0726 0.085
Schistosoma mansoni chromatin regulatory protein sir2 0.063 0.8544 0.9179
Chlamydia trachomatis phosphoglycerate kinase 0.0169 0.2172 1
Plasmodium falciparum transcriptional regulatory protein sir2b 0.0149 0.1895 0.6666
Leishmania major sir2-family protein-like protein 0.0149 0.1895 0.2218
Brugia malayi Phosphoglycerate kinase 0.0169 0.2172 0.2542
Mycobacterium ulcerans Sir2-like regulatory protein 0.0149 0.1895 0.5282
Loa Loa (eye worm) TAR-binding protein 0.0062 0.0699 0.0818
Treponema pallidum NADH oxidase 0.0064 0.0726 0.3116
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0358 0.0412
Echinococcus granulosus transcription factor Dp 1 0.0038 0.036 0.0354
Schistosoma mansoni blooms syndrome DNA helicase 0.0019 0.0096 0.0103
Trichomonas vaginalis conserved hypothetical protein 0.0117 0.1449 0.169
Trypanosoma brucei NADH dehydrogenase 0.0017 0.0072 0.0084
Brugia malayi ImpB/MucB/SamB family protein 0.0064 0.0715 0.0837
Echinococcus multilocularis chromatin regulatory protein sir2 0.063 0.8544 0.8543
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0375 0.5024 0.5881
Loa Loa (eye worm) hypothetical protein 0.0371 0.4967 0.5813
Schistosoma mansoni hypothetical protein 0.002 0.0116 0.0124
Loa Loa (eye worm) hypothetical protein 0.002 0.0112 0.0131
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0038 0.0358 0.0418
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0023 0.0157 0.0551
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0023 0.0157 0.0403
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0017 0.0072 0.0201
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0186 0.2406 0.3716
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.002 0.0112 0.0131
Trypanosoma brucei DNA polymerase kappa, putative 0.0026 0.0201 0.0235
Loa Loa (eye worm) jmjC domain-containing protein 0.002 0.0112 0.0131
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0017 0.0072 0.0077
Trypanosoma brucei polo-like protein kinase 0.0375 0.5024 0.5881
Trypanosoma brucei Mitochondrial import inner membrane translocase subunit TIM50 0.0012 0.0006 0.0007
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.063 0.8544 1
Giardia lamblia Transcriptional regulator, Sir2 family 0.0218 0.2843 0.3328
Giardia lamblia Glycerol-3-phosphate dehydrogenase 0.0017 0.0072 0.0084
Toxoplasma gondii aldehyde dehydrogenase 0.006 0.0669 0.2353
Brugia malayi Protein cec-1. 0.0034 0.0307 0.0359
Echinococcus granulosus jumonji domain containing 1A 0.002 0.0112 0.0106
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0371 0.4967 0.5811
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0117 0.1449 0.278
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0036 0.0329 0.0323
Giardia lamblia NADH oxidase lateral transfer candidate 0.0064 0.0726 0.085
Mycobacterium tuberculosis Probable citrate (pro-3S)-lyase (beta subunit) CitE (citrase) (citratase) (citritase) (citridesmolase) (citrase aldolase) 0.0048 0.05 0.0682
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0017 0.0072 0.0066
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0066 0.0742 0.0868
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0669 0.1865
Echinococcus multilocularis Chromo domain 0.0034 0.0307 0.0301
Plasmodium falciparum thioredoxin reductase 0.0064 0.0726 0.2555
Trypanosoma cruzi DNA polymerase kappa, putative 0.0038 0.0365 0.0428
Echinococcus granulosus jumonji domain containing protein 0.0086 0.1029 0.1023
Onchocerca volvulus 0.0035 0.0315 0.0491
Entamoeba histolytica disulphide oxidoreductase, putative 0.0017 0.0072 0.0077
Plasmodium falciparum ferrodoxin reductase-like protein 0.0017 0.0072 0.0253
Trypanosoma cruzi Silent information regulator 2 related protein 3 0.0218 0.2843 0.3328
Trichomonas vaginalis glutamate synthase, putative 0.0017 0.0072 0.0077
Trypanosoma brucei phosphoglycerate kinase 0.0062 0.0693 0.0811
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0064 0.0726 0.2024
Leishmania major phosphoglycerate kinase C, glycosomal 0.0169 0.2172 0.2542
Plasmodium falciparum NAD(P)H-dependent glutamate synthase, putative 0.0017 0.0072 0.0253
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0048 0.05 0.1394
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0064 0.0726 0.3116
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0329 0.0354
Onchocerca volvulus 0.0083 0.0977 0.1827
Echinococcus granulosus NAD dependent deacetylase sirtuin 1 0.0371 0.4967 0.4964
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0017 0.0072 0.0084
Loa Loa (eye worm) helicase 0.0034 0.0307 0.0359
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0016 0.0056 0.0196
Entamoeba histolytica hypothetical protein 0.0036 0.0329 0.0379
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0037 0.035 0.123
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0083 0.0977 0.1049
Echinococcus granulosus regulator of G protein signaling 7 0.0038 0.0358 0.0352
Echinococcus multilocularis NAD dependent deacetylase sirtuin 3 0.063 0.8544 0.8543
Trichomonas vaginalis conserved hypothetical protein 0.0083 0.0978 0.1138
Plasmodium vivax NAD(P)H-dependent glutamate synthase, putative 0.0017 0.0072 0.0253
Mycobacterium ulcerans dehydrogenase 0.0017 0.0072 0.0201
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0424 0.5699 0.8958
Toxoplasma gondii histone lysine methyltransferase SET1 0.0054 0.0582 0.2049
Trichomonas vaginalis glutathione reductase, putative 0.0064 0.0726 0.0844
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0472 0.6353 1
Trypanosoma brucei hypothetical protein, conserved 0.0017 0.0072 0.0084
Brugia malayi glutaminase DH11.1 0.0271 0.3588 0.42
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0034 0.0307 0.1078
Loa Loa (eye worm) tyrosinase 1 0.0089 0.1067 0.1249
Schistosoma mansoni chromatin regulatory protein sir2 0.063 0.8544 0.9179
Entamoeba histolytica hypothetical protein 0.0038 0.0358 0.0412
Schistosoma mansoni jumonji/arid domain-containing protein 0.0077 0.0896 0.0962
Plasmodium vivax JmjC domain containing protein 0.002 0.0112 0.0395
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0038 0.0358 0.0384
Echinococcus granulosus axis inhibition protein axin 0.0038 0.0358 0.0352
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0016 0.0058 0.0205
Echinococcus multilocularis PHD finger protein rhinoceros 0.0062 0.0693 0.0687
Schistosoma mansoni hypothetical protein 0.0012 0.0004 0.0004
Echinococcus multilocularis chromobox protein 1 0.0208 0.2713 0.2709
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.002 0.0112 0.0131
Echinococcus granulosus chromobox protein 2 0.0034 0.0307 0.0301
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0329 0.0324
Brugia malayi Thioredoxin reductase 0.0186 0.2406 0.2816
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0039 0.0374 0.0438
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0365 0.0428
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.006 0.0669 0.0664
Toxoplasma gondii NADH dehydrogenase (NDH2-II) 0.0017 0.0072 0.0253
Schistosoma mansoni jumonji domain containing protein 0.002 0.0112 0.0121
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0034 0.0307 0.0359
Brugia malayi Heterochromatin protein 1 0.0208 0.2713 0.3176
Brugia malayi PHD-finger family protein 0.0062 0.0693 0.0811
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0023 0.0157 0.0436
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0037 0.0348 0.0401
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0041 0.0396 0.0457
Entamoeba histolytica thioredoxin reductase, putative 0.0017 0.0072 0.0077
Brugia malayi Associated with TFs and helicases family protein 0.0034 0.0307 0.0359
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0669 0.1865
Loa Loa (eye worm) hypothetical protein 0.0034 0.0307 0.0359
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0034 0.0307 0.0352
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprB 0.0017 0.0072 0.0201
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0048 0.05 0.0586
Echinococcus multilocularis regulator of G protein signaling 3 0.0038 0.0358 0.0352
Trypanosoma cruzi polo-like protein kinase, putative 0.0375 0.5024 0.5881
Leishmania major DNA polymerase eta, putative 0.0037 0.035 0.0409
Onchocerca volvulus Alhambra homolog 0.0062 0.0693 0.1254
Loa Loa (eye worm) jmjC domain-containing protein 0.002 0.0112 0.0131
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0017 0.0072 0.0077
Brugia malayi CXXC zinc finger family protein 0.0029 0.023 0.0269
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0329 0.0324
Giardia lamblia Hypothetical protein 0.063 0.8544 1
Giardia lamblia Sirtuin type 2 0.0149 0.1895 0.2218
Mycobacterium tuberculosis Probable dehydrogenase 0.0424 0.5699 0.8958
Leishmania major 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0048 0.05 0.0586
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0218 0.2843 0.3323
Trichomonas vaginalis DNA helicase recq, putative 0.0024 0.0165 0.0186
Leishmania major silent information regulator 2, putative 0.063 0.8544 1
Trypanosoma brucei Silent information regulator 2 related protein 1 0.063 0.8544 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0041 0.0396 0.0457
Brugia malayi glutamate synthase 0.0017 0.0072 0.0084
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0047 0.049 0.0573
Brugia malayi regulator of G-protein signaling rgs-7 0.0038 0.0358 0.0418
Loa Loa (eye worm) hypothetical protein 0.0222 0.2907 0.3403
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0022 0.0135 0.0129
Entamoeba histolytica hypothetical protein 0.0034 0.0307 0.0352
Leishmania major phosphopantetheinyl transferase-like protein 0.0023 0.0157 0.0183
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0034 0.0307 0.0352
Brugia malayi Bromodomain containing protein 0.0062 0.0693 0.0811
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0017 0.0072 0.0077
Loa Loa (eye worm) hypothetical protein 0.0022 0.0138 0.0162
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.002 0.0112 0.0121
Trypanosoma brucei SIR2-like protein 4, putative 0.0149 0.1895 0.2218
Echinococcus granulosus PHD finger protein rhinoceros 0.0062 0.0693 0.0687
Echinococcus granulosus cpg binding protein 0.003 0.0252 0.0247
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0036 0.0329 0.0353
Echinococcus granulosus chromatin regulatory protein sir2 0.063 0.8544 0.8543
Loa Loa (eye worm) ShTK domain-containing protein 0.0089 0.1067 0.1249
Wolbachia endosymbiont of Brugia malayi phosphoglycerate kinase 0.0169 0.2172 1
Brugia malayi hypothetical protein 0.0038 0.0358 0.0418
Schistosoma mansoni protein phosphatase 2C 0.002 0.0112 0.0121
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0149 0.1895 0.2213
Plasmodium vivax glutathione reductase, putative 0.0186 0.2406 0.8463
Echinococcus granulosus dna polymerase kappa 0.0038 0.0365 0.036
Loa Loa (eye worm) hypothetical protein 0.0064 0.0715 0.0837
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.063 0.8544 1
Leishmania major hypothetical protein, conserved 0.0017 0.0072 0.0084
Brugia malayi hypothetical protein 0.0036 0.0329 0.0386
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0017 0.0072 0.0253
Brugia malayi PXA domain containing protein 0.0038 0.0358 0.0418
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0034 0.0307 0.1078
Entamoeba histolytica pyridine nucleotide-disulfide oxidoreductase family protein 0.0017 0.0072 0.0077
Entamoeba histolytica hypothetical protein 0.0034 0.0307 0.0352
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.0672 0.0722
Mycobacterium leprae Probable phosphoglycerate kinase Pgk 0.0169 0.2172 0.3343
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0038 0.0358 0.0384
Loa Loa (eye worm) hypothetical protein 0.0089 0.1067 0.1249
Schistosoma mansoni nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) 0.0012 0.0006 0.0006
Trypanosoma cruzi trypanothione reductase, putative 0.0186 0.2406 0.2816
Echinococcus granulosus Chromobox protein 3 0.0034 0.0307 0.0301
Schistosoma mansoni chromatin regulatory protein sir2 0.0149 0.1895 0.2036
Echinococcus granulosus L aminoadipate semialdehyde 0.0083 0.0977 0.0972
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.002 0.0116 0.0135
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0038 0.0365 0.0467
Plasmodium vivax NLI interacting factor-like phosphatase, putative 0.0012 0.0006 0.0021
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0022 0.014 0.0492
Echinococcus granulosus NAD dependent deacetylase sirtuin 3 0.063 0.8544 0.8543
Schistosoma mansoni glutamate synthase 0.0017 0.0072 0.0077
Brugia malayi ShTK domain containing protein 0.0089 0.1067 0.1249
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0064 0.0726 0.1042
Loa Loa (eye worm) ShTK domain-containing protein 0.0089 0.1067 0.1249
Trichomonas vaginalis CAMK family protein kinase 0.0375 0.5024 0.5878
Schistosoma mansoni phd/f-box containing protein 0.002 0.0112 0.0121
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0424 0.5699 0.8958
Trypanosoma brucei Silent information regulator 2 related protein 3 0.0218 0.2843 0.3328
Schistosoma mansoni regulator of G protein signaling 0.0038 0.0358 0.0384
Entamoeba histolytica hypothetical protein 0.0038 0.0358 0.0412
Loa Loa (eye worm) hypothetical protein 0.0034 0.0307 0.0359
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0064 0.0726 0.0721
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0017 0.0072 0.0066
Schistosoma mansoni chromobox protein 0.0034 0.0307 0.0329
Mycobacterium ulcerans ferredoxin reductase 0.0017 0.0072 0.0201
Schistosoma mansoni hypothetical protein 0.0036 0.0329 0.0354
Echinococcus granulosus citrate lyase subunit beta protein 0.0048 0.05 0.0495
Mycobacterium ulcerans glutamate synthase subunit beta 0.0017 0.0072 0.0201
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0371 0.4967 0.5811
Mycobacterium ulcerans hypothetical protein 0.0048 0.05 0.1394
Trypanosoma cruzi polo-like protein kinase, putative 0.0375 0.5024 0.5881
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0034 0.0307 0.1078
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0017 0.0072 0.0253
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0041 0.0396 0.0457
Schistosoma mansoni glutamate synthase 0.0017 0.0072 0.0077
Entamoeba histolytica deoxycytidyl transferase, putative 0.0038 0.0365 0.0421
Brugia malayi transcriptional regulator, Sir2 family protein 0.0149 0.1895 0.2218
Mycobacterium ulcerans NAD-dependent deacetylase 0.0218 0.2843 0.7924
Mycobacterium tuberculosis Probable oxidoreductase 0.0472 0.6353 1
Trypanosoma cruzi NADH dehydrogenase, putative 0.0017 0.0072 0.0084
Loa Loa (eye worm) hypothetical protein 0.0034 0.0307 0.0359
Trypanosoma cruzi 2,4-dienoyl-coa reductase-like protein, putative 0.0017 0.0072 0.0084
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0064 0.0726 0.085
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0017 0.0072 0.0066
Loa Loa (eye worm) CHromoDomain protein family member 0.0036 0.0329 0.0385
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.063 0.8544 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0006 0.0007
Loa Loa (eye worm) hypothetical protein 0.0012 0.0004 0.0004
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0023 0.0157 0.0551
Trichomonas vaginalis hypothetical protein 0.0034 0.0307 0.0352
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0017 0.0072 0.0084
Schistosoma mansoni phosphatidylserine receptor 0.002 0.0112 0.0121
Brugia malayi ImpB/MucB/SamB family protein 0.0038 0.0365 0.0428
Brugia malayi jmjC domain containing protein 0.002 0.0112 0.0131
Schistosoma mansoni chromatin regulatory protein sir2 0.063 0.8544 0.9179
Trypanosoma brucei trypanothione reductase 0.0186 0.2406 0.2816
Brugia malayi SET domain containing protein 0.0035 0.0315 0.0369
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0126 0.1571 0.3027
Trichomonas vaginalis glutamate synthase, putative 0.0017 0.0072 0.0077
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0017 0.0072 0.0066
Trypanosoma brucei hypothetical protein, conserved 0.0023 0.0157 0.0183
Brugia malayi Hypothetical tyrosinase-like protein F21C3.2 in chromosome I 0.0089 0.1067 0.1249
Trypanosoma cruzi hypothetical protein, conserved 0.0017 0.0072 0.0084
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0064 0.0726 0.085
Plasmodium vivax NAD-dependent deacetylase, putative 0.0218 0.2843 1
Brugia malayi hypothetical protein 0.0038 0.0358 0.0418
Loa Loa (eye worm) transcription factor SMAD2 0.0119 0.1474 0.1726
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.0017 0.0072 0.0077
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.006 0.0669 0.0664
Loa Loa (eye worm) hypothetical protein 0.0038 0.0358 0.0418
Schistosoma mansoni jumonji domain containing protein 0.0161 0.2066 0.222
Trypanosoma cruzi DNA polymerase kappa, putative 0.0038 0.0365 0.0428
Loa Loa (eye worm) hypothetical protein 0.0091 0.11 0.1288
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.002 0.0112 0.0131
Brugia malayi jmjC domain containing protein 0.0077 0.0896 0.1048
Plasmodium vivax hypothetical protein, conserved 0.0034 0.0307 0.1078
Plasmodium falciparum JmjC domain-containing protein, putative 0.002 0.0112 0.0395
Onchocerca volvulus 0.0089 0.1067 0.2009
Schistosoma mansoni regulator of G protein signaling 0.0038 0.0358 0.0384
Schistosoma mansoni chromatin regulatory protein sir2 0.0371 0.4967 0.5336
Plasmodium falciparum glutathione reductase 0.0186 0.2406 0.8463
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0064 0.0726 0.085
Echinococcus granulosus NAD dependent deacetylase sirtuin 6 0.0149 0.1895 0.189
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0358 0.0412
Trypanosoma cruzi DNA polymerase kappa, putative 0.0038 0.0365 0.0428
Schistosoma mansoni sulfide quinone reductase 0.0017 0.0072 0.0077
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0023 0.0157 0.0403
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0472 0.6353 1
Echinococcus granulosus peregrin 0.0062 0.0693 0.0687
Echinococcus multilocularis beta adrenergic receptor kinase 0.0039 0.0374 0.0369
Toxoplasma gondii PHD-finger domain-containing protein 0.002 0.0116 0.0407
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0169 0.2172 0.2542
Toxoplasma gondii phosphoglycerate kinase PGKI 0.0169 0.2172 0.7639
Loa Loa (eye worm) RGS-3 protein 0.0038 0.0358 0.0418
Echinococcus multilocularis JmjC domain containing protein 4 0.002 0.0112 0.0106
Echinococcus multilocularis NAD dependent deacetylase sirtuin 7 0.0149 0.1895 0.189
Mycobacterium tuberculosis Probable phosphoglycerate kinase Pgk 0.0169 0.2172 0.3343
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0699 0.0751
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0017 0.0072 0.0084
Loa Loa (eye worm) hypothetical protein 0.012 0.1494 0.1749
Brugia malayi regulator of G-protein signaling egl-10 0.0038 0.0358 0.0418
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0047 0.049 0.0573
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0307 0.0352
Loa Loa (eye worm) hypothetical protein 0.0083 0.0977 0.1143
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0017 0.0072 0.0077
Giardia lamblia Glutamate synthase 0.0017 0.0072 0.0084
Echinococcus multilocularis regulator of G protein signaling 3 0.0038 0.0358 0.0352
Trypanosoma brucei DNA polymerase kappa, putative 0.0026 0.0201 0.0235
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0034 0.0307 0.0352
Entamoeba histolytica recQ family helicase, putative 0.0013 0.0012 0.0007
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0169 0.2172 0.2537
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0034 0.0307 0.0329
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0064 0.0726 0.3116
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0041 0.0396 0.0457
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0358 0.0412
Onchocerca volvulus Serine\/threonine kinase homolog 0.0375 0.5024 1
Schistosoma mansoni serine/threonine protein kinase 0.0375 0.5024 0.5398
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0062 0.0693 0.0811
Plasmodium falciparum glutathione reductase 0.0064 0.0726 0.2555
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0218 0.2843 0.3323
Trichomonas vaginalis CAMK family protein kinase 0.0375 0.5024 0.5878
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0064 0.0726 0.085
Trypanosoma cruzi hypothetical protein, conserved 0.0418 0.5608 0.6563
Loa Loa (eye worm) hypothetical protein 0.0062 0.0693 0.0811
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.063 0.8544 1
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0017 0.0072 0.0077
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0669 0.1865
Leishmania major hypothetical protein, conserved 0.002 0.0112 0.0131
Trypanosoma cruzi 3-phosphoglycerate kinase, glycosomal 0.0062 0.0693 0.0811
Schistosoma mansoni sulfide quinone reductase 0.0017 0.0072 0.0077
Echinococcus multilocularis phosphoglycerate kinase 1 0.0169 0.2172 0.2167
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0017 0.0072 0.0201
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0017 0.0072 0.0066
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.006 0.0669 0.0783
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0038 0.0358 0.0352
Echinococcus multilocularis jumonji domain containing 1A 0.002 0.0112 0.0106
Brugia malayi F/Y-rich N-terminus family protein 0.0029 0.0236 0.0276
Echinococcus granulosus Regulator of G protein signaling 20 0.0038 0.0358 0.0352
Echinococcus multilocularis dna polymerase eta 0.0064 0.0715 0.071
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0365 0.0428
Schistosoma mansoni tyrosinase precursor 0.0089 0.1067 0.1146
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0203 0.2643 0.2639
Echinococcus granulosus regulator of G protein signaling 3 0.0038 0.0358 0.0352
Trypanosoma cruzi hypothetical protein, conserved 0.0012 0.0006 0.0007
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0089 0.1067 0.1249
Mycobacterium ulcerans hypothetical protein 0.0017 0.0072 0.0201
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0375 0.5024 0.5021
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0013 0.0012 0.0014
Schistosoma mansoni cpg binding protein 0.003 0.0252 0.0271
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0424 0.5699 0.8958
Entamoeba histolytica hypothetical protein, conserved 0.0149 0.1895 0.2213
Trypanosoma cruzi Silent information regulator 2 related protein 3 0.0218 0.2843 0.3328
Echinococcus multilocularis Chromobox protein 3 0.0034 0.0307 0.0301
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0371 0.4967 0.5811
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0064 0.0726 0.2024
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0017 0.0072 0.0077
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0048 0.05 0.0586
Loa Loa (eye worm) hypothetical protein 0.0034 0.0307 0.0359
Trypanosoma cruzi 2,4-dienoyl-coa reductase fadh1, putative 0.0017 0.0072 0.0084
Loa Loa (eye worm) hypothetical protein 0.0034 0.0307 0.0359
Plasmodium vivax NLI interacting factor-like phosphatase, putative 0.0012 0.0006 0.0021
Trypanosoma brucei hypothetical protein, conserved 0.0418 0.5608 0.6563
Echinococcus granulosus tar DNA binding protein 0.0062 0.0699 0.0693
Echinococcus granulosus axis inhibition protein axin 0.0038 0.0358 0.0352
Onchocerca volvulus 0.0029 0.023 0.0319
Toxoplasma gondii selenide, water dikinase 0.0017 0.0072 0.0253
Loa Loa (eye worm) jmjC domain-containing protein 0.0077 0.0896 0.1048
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0365 0.0428
Brugia malayi CHD4 protein 0.0036 0.0329 0.0385
Brugia malayi MH2 domain containing protein 0.0119 0.1474 0.1726
Echinococcus granulosus beta-adrenergic receptor kinase 0.0039 0.0374 0.0369
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0013 0.0012 0.0014
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0066 0.0742 0.0736
Leishmania major hypothetical protein, conserved 0.0012 0.0006 0.0007
Echinococcus multilocularis Regulator of G protein signaling 20 0.0038 0.0358 0.0352
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0375 0.5024 0.5881
Trichomonas vaginalis conserved hypothetical protein 0.0117 0.1449 0.169
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0149 0.1895 0.2213
Loa Loa (eye worm) RNA binding protein 0.0062 0.0699 0.0818
Schistosoma mansoni tyrosinase precursor 0.0089 0.1067 0.1146
Loa Loa (eye worm) hypothetical protein 0.0117 0.1449 0.1696
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0017 0.0072 0.0066
Trypanosoma brucei 2,4-dienoyl-coa reductase-like protein 0.0017 0.0072 0.0084
Onchocerca volvulus 0.0034 0.0307 0.0474
Schistosoma mansoni kinase 0.0191 0.2473 0.2656
Mycobacterium ulcerans DNA polymerase IV 0.0038 0.0365 0.1018
Schistosoma mansoni cpg binding protein 0.0029 0.023 0.0247
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0365 0.0428
Loa Loa (eye worm) glutaminase 2 0.0271 0.3588 0.42
Echinococcus granulosus phd:f box containing protein 0.002 0.0112 0.0106
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0023 0.0157 0.0551
Trichomonas vaginalis mercuric reductase, putative 0.0064 0.0726 0.0844
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0365 0.0428
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0041 0.0396 0.0457
Schistosoma mansoni serine/threonine protein kinase 0.0039 0.0374 0.0402
Schistosoma mansoni regulator of G protein signaling 0.0038 0.0358 0.0384
Echinococcus granulosus JmjC domain containing protein 4 0.002 0.0112 0.0106
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0034 0.0307 0.0352
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0064 0.0726 0.085
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0365 0.0428
Trypanosoma cruzi DNA polymerase eta, putative 0.0037 0.035 0.0409
Echinococcus multilocularis expressed protein 0.0735 1 1
Plasmodium vivax hypothetical protein, conserved 0.0022 0.014 0.0492
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0038 0.0358 0.0352
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0365 0.0428
Brugia malayi chromobox protein homolog 3 0.0117 0.1449 0.1696
Loa Loa (eye worm) hypothetical protein 0.0038 0.0358 0.0418
Trypanosoma brucei phosphoglycerate kinase, putative 0.0062 0.0693 0.0811
Schistosoma mansoni jumonji/arid domain-containing protein 0.0077 0.0896 0.0962
Trichomonas vaginalis CAMK family protein kinase 0.0375 0.5024 0.5878
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0064 0.0726 0.2024
Brugia malayi jmjC domain containing protein 0.002 0.0112 0.0131
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0027 0.0214 0.023
Echinococcus multilocularis citrate lyase subunit beta protein 0.0048 0.05 0.0495
Entamoeba histolytica NAD-dependent deacetylase 1, putative 0.0149 0.1895 0.2213
Trichomonas vaginalis Heterochromatin protein, putative 0.0034 0.0307 0.0352
Trypanosoma brucei unspecified product 0.0038 0.0365 0.0428
Mycobacterium ulcerans DNA polymerase IV 0.0038 0.0365 0.1018
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0064 0.0726 0.2555
Schistosoma mansoni hypothetical protein 0.0017 0.0072 0.0077
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.023 0.0269
Echinococcus multilocularis cpg binding protein 0.003 0.0252 0.0247
Toxoplasma gondii NADPH-glutathione reductase 0.0064 0.0726 0.2555
Brugia malayi PHD-finger family protein 0.0022 0.0138 0.0162
Brugia malayi glutathione reductase 0.0186 0.2406 0.2816
Mycobacterium ulcerans NADPH dependent 2,4-dienoyl-CoA reductase FadH 0.0017 0.0072 0.0201
Brugia malayi Phosphoglycerate kinase 0.0062 0.0693 0.0811
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0041 0.0396 0.0457
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0017 0.0072 0.0066
Mycobacterium ulcerans NADH dehydrogenase 0.0017 0.0072 0.0201
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0034 0.0307 0.0301
Schistosoma mansoni phosphoglycerate kinase 0.0169 0.2172 0.2333
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0066 0.0742 0.0868
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0064 0.0726 0.085
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0062 0.0693 0.0744
Trichomonas vaginalis chromobox protein, putative 0.0034 0.0307 0.0352
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0307 0.0352
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0021 0.0125 0.044
Leishmania major hypothetical protein, conserved 0.0017 0.0072 0.0084
Brugia malayi AF-10 protein 0.002 0.0116 0.0135
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.002 0.0116 0.0135

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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