Detailed information for compound 724850

Basic information

Technical information
  • TDR Targets ID: 724850
  • Name: N-[4-[4-(furan-2-carbonyl)piperazine-1-carbon yl]phenyl]propanamide
  • MW: 355.388 | Formula: C19H21N3O4
  • H donors: 1 H acceptors: 3 LogP: 1.36 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCC(=O)Nc1ccc(cc1)C(=O)N1CCN(CC1)C(=O)c1ccco1
  • InChi: 1S/C19H21N3O4/c1-2-17(23)20-15-7-5-14(6-8-15)18(24)21-9-11-22(12-10-21)19(25)16-4-3-13-26-16/h3-8,13H,2,9-12H2,1H3,(H,20,23)
  • InChiKey: HIUXVEDHLDBPNU-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-[4-[[4-(2-furyl-oxomethyl)-1-piperazinyl]-oxomethyl]phenyl]propanamide
  • N-[4-[4-(furan-2-carbonyl)piperazine-1-carbonyl]phenyl]propionamide
  • N-[4-(4-furan-2-ylcarbonylpiperazin-1-yl)carbonylphenyl]propanamide
  • MLS000674176
  • N-(4-{[4-(2-furoyl)-1-piperazinyl]carbonyl}phenyl)propanamide
  • SMR000297072
  • ZINC04814409
  • STK218143

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi hypothetical protein 0.0712 0.4255 0.9816
Toxoplasma gondii NADPH-glutathione reductase 0.0015 0.0024 0.0041
Loa Loa (eye worm) hypothetical protein 0.0019 0.0051 0.0113
Toxoplasma gondii zinc carboxypeptidase superfamily protein 0.0022 0.0066 0.0183
Brugia malayi Carboxypeptidase A2 precursor 0.0022 0.0066 0.0153
Trichomonas vaginalis CMGC family protein kinase 0.0022 0.0066 0.0144
Brugia malayi glutathione reductase 0.0044 0.0198 0.0458
Plasmodium vivax glutathione reductase, putative 0.0044 0.0198 0.063
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0091 0.0207
Schistosoma mansoni metallocarboxypeptidase D peptidase unit 2 (M14 family) 0.0022 0.0066 0.0062
Giardia lamblia Nuclear ATP/GTP-binding protein 0.0022 0.0066 0.0097
Brugia malayi LD47325p 0.0019 0.0051 0.0117
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0015 0.0024 0.0078
Loa Loa (eye worm) hypothetical protein 0.0042 0.0185 0.0422
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0121 0.067 0.0667
Schistosoma mansoni aryl hydrocarbon receptor 0.0045 0.0206 0.0202
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0012 0.0005 0.0011
Plasmodium falciparum basic transcription factor 3b, putative 0.0034 0.0141 0.0428
Echinococcus multilocularis cytosolic carboxypeptidase protein 5 0.0022 0.0066 0.0063
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0164 0.037
Loa Loa (eye worm) ICD-1 protein 0.0034 0.0141 0.0322
Mycobacterium ulcerans aldehyde dehydrogenase 0.0121 0.067 0.1542
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0053 0.0255 0.0251
Loa Loa (eye worm) hypothetical protein 0.0022 0.0066 0.0149
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0018 0.004 0.0036
Loa Loa (eye worm) hypothetical protein 0.0712 0.4255 0.9815
Loa Loa (eye worm) glutathione reductase 0.0044 0.0198 0.0454
Trypanosoma cruzi kinesin, putative 0.0019 0.0045 0.0149
Schistosoma mansoni arginase 0.017 0.0967 0.0964
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0019 0.0045 0.0149
Echinococcus multilocularis calpain A 0.0066 0.0332 0.0328
Schistosoma mansoni transcription factor btf3 0.0034 0.0141 0.0137
Trichomonas vaginalis CMGC family protein kinase 0.0022 0.0066 0.0144
Schistosoma mansoni blooms syndrome DNA helicase 0.0016 0.0027 0.0023
Echinococcus multilocularis transcription factor btf3 0.0034 0.0141 0.0138
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0015 0.0024 0.0078
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0019 0.0045 0.0149
Trichomonas vaginalis hypothetical protein 0.0014 0.0018 0.0034
Leishmania major protein kinase, putative 0.0012 0.0005 0.0011
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.005 0.0233 0.0535
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0026 0.0092 0.0205
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0091 0.0483 0.0479
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0015 0.0024 0.0056
Plasmodium vivax ubiquitin-conjugating enzyme E2 N, putative 0.0496 0.2947 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.0066 0.0149
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0012 0.0005 0.0011
Schistosoma mansoni cpg binding protein 0.0123 0.0679 0.0675
Schistosoma mansoni calpain (C02 family) 0.0019 0.0045 0.0041
Loa Loa (eye worm) hypothetical protein 0.003 0.0116 0.0264
Onchocerca volvulus 0.0044 0.0199 0.0452
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0093 0.0271
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0111 0.0607 0.1352
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0027 0.0094 0.0091
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0015 0.0024 0.003
Plasmodium falciparum glutathione reductase 0.0015 0.0024 0.003
Trichomonas vaginalis Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase 0.0022 0.0066 0.0145
Echinococcus granulosus transcription factor btf3 0.0034 0.0141 0.0138
Loa Loa (eye worm) hypothetical protein 0.0071 0.0363 0.0834
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0015 0.0024 1
Schistosoma mansoni hypothetical protein 0.0032 0.013 0.0125
Onchocerca volvulus Carboxypeptidase D homolog 0.0042 0.0185 0.0418
Brugia malayi hypothetical protein 0.0113 0.0617 0.1424
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0015 0.0024 0.003
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.013 0.0126
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0091 0.0483 0.0479
Trichomonas vaginalis CMGC family protein kinase 0.0022 0.0066 0.0144
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0038 0.0164 0.055
Echinococcus multilocularis neuropeptide s receptor 0.0452 0.2677 0.2675
Trypanosoma brucei hypothetical protein, conserved 0.0055 0.0266 0.0898
Schistosoma mansoni ap endonuclease 0.0038 0.0164 0.0159
Onchocerca volvulus 0.0093 0.0497 0.1139
Toxoplasma gondii thioredoxin reductase 0.0044 0.0198 0.0633
Trichomonas vaginalis Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase 0.0022 0.0066 0.0145
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0006 0.0007
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0483 0.0478
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0019 0.0045 0.0149
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0022 0.0066 0.0218
Trichomonas vaginalis Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase 0.0022 0.0066 0.0145
Trypanosoma brucei kinesin, putative 0.0019 0.0045 0.0149
Leishmania major kinesin, putative 0.0019 0.0045 0.0149
Brugia malayi Zinc carboxypeptidase family protein 0.0042 0.0185 0.0426
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0121 0.067 0.0667
Trypanosoma cruzi kinesin, putative 0.0019 0.0045 0.0149
Schistosoma mansoni hypothetical protein 0.0022 0.0066 0.0062
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0725 0.4335 1
Echinococcus multilocularis bloom syndrome protein 0.002 0.0052 0.0049
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0093 0.031
Trichomonas vaginalis conserved hypothetical protein 0.017 0.0967 0.2226
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0015 0.0024 0.0078
Brugia malayi calpain family protein 1 0.0063 0.0312 0.072
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0015 0.0024 0.0078
Echinococcus granulosus arginase 2 mitochondrial 0.017 0.0967 0.0964
Onchocerca volvulus 0.003 0.0116 0.0259
Trypanosoma cruzi ubiquitin-conjugating enzyme E2, putative 0.0496 0.2947 1
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0038 0.0164 0.0323
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1593 0.9611 0.9611
Brugia malayi F/Y-rich N-terminus family protein 0.0037 0.0154 0.0356
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0092 0.0205
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.003 0.0114 0.0111
Echinococcus granulosus neuropeptide s receptor 0.0452 0.2677 0.2675
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0116 0.0111
Loa Loa (eye worm) ubiquitin conjugating enzyme protein 13 0.0496 0.2947 0.6798
Trypanosoma cruzi metallo-peptidase, Clan MC, Family M14, putative 0.0022 0.0066 0.022
Toxoplasma gondii aldehyde dehydrogenase 0.0121 0.067 0.224
Leishmania major zinc carboxypeptidase, putative,metallo-peptidase, Clan MC, Family M14 0.0022 0.0066 0.022
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0038 0.0164 0.016
Schistosoma mansoni intermediate filament proteins 0.0026 0.0091 0.0087
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0015 0.0024 0.0053
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0019 0.0045 0.0149
Loa Loa (eye worm) hypothetical protein 0.0016 0.0028 0.0061
Mycobacterium ulcerans aldehyde dehydrogenase 0.0121 0.067 0.1542
Echinococcus multilocularis calpain 0.0019 0.0045 0.0042
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0012 0.0003 0.0007
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0015 0.0024 0.0078
Trypanosoma cruzi Enriched in surface-labeled proteome protein 12 0.0055 0.0266 0.0898
Echinococcus granulosus 3'partial|arginase 2 mitochondrial 0.017 0.0967 0.0964
Schistosoma mansoni Mername-AA248 (C02 family) 0.0019 0.0045 0.0041
Leishmania major protein kinase, putative 0.0012 0.0005 0.0011
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0091 0.0483 0.1113
Brugia malayi CXXC zinc finger family protein 0.0116 0.0639 0.1474
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0015 0.0024 0.0078
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0026 0.0092 0.0205
Brugia malayi latrophilin 2 splice variant baaae 0.007 0.0359 0.0827
Toxoplasma gondii zinc carboxypeptidase, putative 0.0022 0.0066 0.0183
Leishmania major trypanothione reductase 0.0044 0.0198 0.0668
Onchocerca volvulus 0.0222 0.1281 0.295
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0195 0.1119 0.2579
Mycobacterium tuberculosis Putative ferredoxin reductase 0.01 0.0539 0.1195
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0026 0.0092 0.0205
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0053 0.0255 0.0589
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0012 0.0004 0.0001
Trypanosoma cruzi ISWI complex protein 0.0012 0.0006 0.0017
Schistosoma mansoni aldehyde dehydrogenase 0.0121 0.067 0.0666
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0037 0.0157 0.0154
Trichomonas vaginalis Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase 0.0022 0.0066 0.0145
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0725 0.4335 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.0066 0.0149
Loa Loa (eye worm) hypothetical protein 0.0026 0.0088 0.02
Loa Loa (eye worm) zinc carboxypeptidase 0.0042 0.0185 0.0422
Brugia malayi Thioredoxin reductase 0.0044 0.0198 0.0458
Plasmodium falciparum arginase 0.017 0.0967 0.3247
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0015 0.0024 0.0053
Leishmania major hypothetical protein, conserved 0.0026 0.0093 0.031
Loa Loa (eye worm) hypothetical protein 0.0063 0.0312 0.0717
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0019 0.0045 0.0149
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0164 0.037
Trypanosoma cruzi Carboxypeptidase-like protein 0.0022 0.0066 0.022
Leishmania major arginase 0.017 0.0967 0.3279
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.003 0.0114 0.0111
Schistosoma mansoni hypothetical protein 0.0032 0.013 0.0125
Loa Loa (eye worm) calpain 0.0019 0.0045 0.0101
Loa Loa (eye worm) hypothetical protein 0.0022 0.0066 0.0149
Toxoplasma gondii ubiquitin-conjugating enzyme subfamily protein 0.0496 0.2947 1
Trypanosoma brucei antigen, putative 0.0019 0.0045 0.0149
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0091 0.021
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0066 0.0332 0.0327
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0012 0.0005 0.0011
Loa Loa (eye worm) calpain family protein 1 0.0063 0.0312 0.0717
Echinococcus granulosus mixed lineage leukemia protein mll 0.003 0.0114 0.0111
Trichomonas vaginalis set domain proteins, putative 0.0222 0.1281 0.295
Plasmodium vivax calpain, putative 0.0019 0.0045 0.0109
Echinococcus multilocularis 0.017 0.0967 0.0964
Schistosoma mansoni hypothetical protein 0.007 0.0359 0.0354
Schistosoma mansoni calpain-7 (C02 family) 0.0019 0.0045 0.0041
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0116 0.0112
Toxoplasma gondii NAC domain-containing protein 0.0034 0.0141 0.0438
Echinococcus multilocularis geminin 0.0675 0.4032 0.403
Brugia malayi bHLH-PAS transcription factor 0.0033 0.0135 0.0311
Trypanosoma cruzi arginase, putative 0.0062 0.0309 0.1044
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0015 0.0024 0.0078
Echinococcus multilocularis muscleblind protein 1 0.0147 0.0824 0.0821
Schistosoma mansoni ubiquitin conjugating enzyme 13 0.0496 0.2947 0.2944
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0022 0.0066 0.0218
Trichomonas vaginalis helicase, putative 0.0026 0.0092 0.0205
Trypanosoma brucei agmatinase, putative 0.0062 0.0309 0.1044
Loa Loa (eye worm) thioredoxin reductase 0.0044 0.0198 0.0454
Echinococcus granulosus GPCR family 2 0.0032 0.013 0.0126
Onchocerca volvulus 0.0022 0.0066 0.0145
Schistosoma mansoni peptidase 0.0022 0.0066 0.0062
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0026 0.0092 0.0205
Schistosoma mansoni myst-related protein 0.0014 0.0016 0.0011
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0111 0.0607 0.1352
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0038 0.0164 0.0374
Trypanosoma brucei calpain-like protein, putative 0.0019 0.0045 0.0149
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0164 0.0504
Loa Loa (eye worm) hypothetical protein 0.007 0.0359 0.0824
Onchocerca volvulus 0.0033 0.0135 0.0304
Echinococcus multilocularis survival motor neuron protein 1 0.0712 0.4255 0.4253
Brugia malayi calpain 5 0.0019 0.0045 0.0105
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0116 0.0352
Trypanosoma cruzi agmatinase, putative 0.0062 0.0309 0.1044
Treponema pallidum exodeoxyribonuclease (exoA) 0.0038 0.0164 1
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0092 0.0205
Leishmania major zinc carboxypeptidase, putative,metallo-peptidase, Clan MC, Family M14 0.0022 0.0066 0.022
Brugia malayi Zinc carboxypeptidase family protein 0.0022 0.0066 0.0153
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0015 0.0024 0.0021
Loa Loa (eye worm) calpain 5 0.0019 0.0045 0.0101
Trichomonas vaginalis Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase 0.0022 0.0066 0.0145
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0006 0.0007
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0019 0.0045 0.0149
Onchocerca volvulus 0.0725 0.4335 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.0066 0.0149
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0483 0.0478
Trypanosoma brucei Carboxypeptidase-like protein 0.0022 0.0066 0.022
Leishmania major agmatinase-like protein 0.0062 0.0309 0.1044
Echinococcus granulosus calpain 0.0019 0.0045 0.0042
Echinococcus multilocularis musashi 0.0026 0.0091 0.0088
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0053 0.0255 0.0861
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.0496 0.2947 0.6797
Plasmodium falciparum thioredoxin reductase 0.0044 0.0198 0.0623
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0121 0.067 0.1497
Onchocerca volvulus Subfamily M14A unassigned peptidase homolog 0.0093 0.0497 0.1139
Trichomonas vaginalis Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase 0.0022 0.0066 0.0145
Loa Loa (eye worm) zinc carboxypeptidase 0.0022 0.0066 0.0149
Trypanosoma brucei calpain-like protein, putative 0.0019 0.0045 0.0149
Brugia malayi Bloom's syndrome protein homolog 0.002 0.0052 0.0121
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0121 0.067 0.2269
Loa Loa (eye worm) zinc carboxypeptidase 0.0022 0.0066 0.0149
Schistosoma mansoni serine/threonine protein kinase 0.0022 0.0066 0.0061
Echinococcus granulosus lamin dm0 0.0026 0.0091 0.0088
Echinococcus granulosus mitogen activated protein kinase 0.0022 0.0066 0.0062
Onchocerca volvulus Cytosolic carboxypeptidase 1 homolog 0.0022 0.0066 0.0145
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0092 0.0205
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0093 0.0263
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0038 0.0164 0.0323
Trichomonas vaginalis DNA helicase recq1, putative 0.002 0.0052 0.0113
Trypanosoma cruzi transcription factor btf3, putative 0.0034 0.0141 0.0474
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0044 0.0198 0.0404
Trypanosoma brucei metallo-peptidase, Clan MC, Family M14, putative 0.0022 0.0066 0.022
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.01 0.0539 0.8878
Trypanosoma cruzi zinc carboxypeptidase, putative 0.0022 0.0066 0.022
Echinococcus multilocularis GPCR, family 2 0.0032 0.013 0.0126
Echinococcus multilocularis mitogen activated protein kinase 0.0022 0.0066 0.0062
Schistosoma mansoni single-minded 0.0045 0.0206 0.0202
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.0496 0.2947 0.6797
Loa Loa (eye worm) RecQ helicase 0.002 0.0052 0.0117
Trichomonas vaginalis carboxypeptidase regulatory region-containing protein, putative 0.0019 0.0051 0.0109
Trypanosoma cruzi Enriched in surface-labeled proteome protein 12 0.0055 0.0266 0.0898
Trypanosoma brucei Enriched in surface-labeled proteome protein 12 0.0055 0.0266 0.0898
Trypanosoma brucei hypothetical protein, conserved 0.0055 0.0266 0.0898
Onchocerca volvulus 0.0026 0.0091 0.0202
Echinococcus multilocularis hypothetical protein 0.0019 0.0045 0.0042
Brugia malayi beta-NAC-like protein 0.0034 0.0141 0.0325
Plasmodium vivax thioredoxin reductase, putative 0.0044 0.0198 0.063
Echinococcus multilocularis calpain family protein 1, d 0.0044 0.0199 0.0196
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0019 0.0045 0.0149
Mycobacterium ulcerans putative regulatory protein 0.0033 0.0135 0.0308
Loa Loa (eye worm) hypothetical protein 0.0022 0.0066 0.0149
Echinococcus granulosus calpain A 0.0019 0.0045 0.0042
Echinococcus multilocularis calpain 7 (C02 family) 0.0019 0.0045 0.0042
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0017 0.0038 0.0075
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0022 0.0066 0.0218
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.013 0.0296
Brugia malayi Zinc carboxypeptidase family protein 0.0022 0.0066 0.0153
Schistosoma mansoni protease m14 carboxypeptidase 0.0022 0.0066 0.0062
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0091 0.0207
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0015 0.0024 0.0038
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0141 0.0318
Trypanosoma brucei calpain-like protein, putative 0.0019 0.0045 0.0149
Loa Loa (eye worm) hypothetical protein 0.0026 0.0091 0.0207
Brugia malayi follicle stimulating hormone receptor 0.0242 0.1404 0.324
Trichomonas vaginalis Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase 0.0022 0.0066 0.0145
Echinococcus granulosus mitogen activated protein kinase 3 0.0022 0.0066 0.0062
Brugia malayi hypoxia-induced factor 1 0.014 0.078 0.1799
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0015 0.0024 0.0078
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0092 0.0205
Leishmania major basic transcription factor 3a, putative 0.0034 0.0141 0.0474
Echinococcus multilocularis lamin dm0 0.0026 0.0091 0.0088
Loa Loa (eye worm) hypothetical protein 0.0026 0.0093 0.0211
Onchocerca volvulus 0.0093 0.0497 0.1139
Brugia malayi Ubiquitin conjugating enzyme protein 13 0.0496 0.2947 0.6799
Schistosoma mansoni cpg binding protein 0.0116 0.0639 0.0635
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.01 0.0539 0.1195
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0037 0.0157 0.0154
Loa Loa (eye worm) hypothetical protein 0.0147 0.0824 0.1899
Echinococcus multilocularis mixed lineage leukemia protein mll 0.003 0.0114 0.0111
Brugia malayi hypothetical protein 0.0017 0.0036 0.0083
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0242 0.1404 0.3237
Trypanosoma brucei ubiquitin-protein ligase, putative 0.0496 0.2947 1
Echinococcus multilocularis mitogen activated protein kinase 3 0.0022 0.0066 0.0062
Echinococcus multilocularis subfamily M14A unassigned peptidase 0.0093 0.0497 0.0494
Mycobacterium tuberculosis Probable oxidoreductase 0.0111 0.0607 0.1352
Entamoeba histolytica ubiquitin-conjugating enzyme family protein 0.0496 0.2947 0.6788
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0091 0.0483 0.0479
Echinococcus granulosus cytosolic carboxypeptidase 1 0.0022 0.0066 0.0063
Trichomonas vaginalis Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase 0.0022 0.0066 0.0145
Schistosoma mansoni subfamily M14A unassigned peptidase (M14 family) 0.0093 0.0497 0.0493
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0093 0.031
Entamoeba histolytica transcription factor BTF3, putative 0.0034 0.0141 0.029
Brugia malayi ubiquitin conjugating enzyme protein 13 0.0496 0.2947 0.6799
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0038 0.0164 0.016
Echinococcus granulosus thioredoxin glutathione reductase 0.0044 0.0198 0.0195
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0015 0.0024 0.0078
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0092 0.0205
Echinococcus multilocularis muscleblind protein 0.0147 0.0824 0.0821
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0053 0.0255 0.0252
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0019 0.0045 0.0149
Mycobacterium ulcerans aldehyde dehydrogenase 0.0121 0.067 0.1542
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0725 0.4335 1
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0725 0.4335 1
Echinococcus multilocularis cpg binding protein 0.0123 0.0679 0.0676
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0092 0.0205
Loa Loa (eye worm) hypothetical protein 0.0063 0.0312 0.0717
Trichomonas vaginalis Arginase, putative 0.017 0.0967 0.2226
Echinococcus multilocularis transfer RNA-Lys 0.0033 0.0135 0.0132
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0038 0.0164 0.055
Loa Loa (eye worm) ubiquitin conjugating enzyme protein 13 0.0496 0.2947 0.6798
Brugia malayi hypothetical protein 0.0151 0.0851 0.1963
Mycobacterium tuberculosis Probable reductase 0.01 0.0539 0.1195
Brugia malayi PAS domain containing protein 0.0045 0.0206 0.0475
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0012 0.0003 0.0004
Trypanosoma cruzi Enriched in surface-labeled proteome protein 12 0.0055 0.0266 0.0898
Trypanosoma brucei transcription factor BTF3, putative 0.0034 0.0141 0.0474
Trypanosoma brucei protein kinase, putative 0.0022 0.0066 0.0218
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0019 0.0045 0.0149
Echinococcus granulosus geminin 0.0675 0.4032 0.403
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0093 0.0274
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0015 0.0024 0.002
Giardia lamblia Low molecular weight protein-tyrosine-phosphatase 0.0725 0.4335 1
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0038 0.0164 0.0342
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.013 0.0126
Brugia malayi Cytochrome P450 family protein 0.0011 0.0001 0.0003
Brugia malayi Pre-SET motif family protein 0.003 0.0116 0.0267
Entamoeba histolytica hypothetical protein 0.0034 0.0141 0.029
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0015 0.0024 0.0078
Loa Loa (eye worm) calpain family protein 1 0.0044 0.0199 0.0456
Trypanosoma brucei calpain-like protein, putative 0.0019 0.0045 0.0149
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0091 0.0483 0.0479
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0038 0.0164 0.0374
Giardia lamblia Kinase, CMGC MAPK 0.0022 0.0066 0.0096
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.0066 0.0332 0.0328
Echinococcus multilocularis 0.0022 0.0066 0.0063
Loa Loa (eye worm) histone methyltransferase 0.0037 0.0157 0.0359
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0092 0.0205
Loa Loa (eye worm) hypothetical protein 0.0103 0.0556 0.1279
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0116 0.0112
Echinococcus granulosus single minded 2 0.0033 0.0135 0.0132
Trichomonas vaginalis mercuric reductase, putative 0.0015 0.0024 0.0049
Echinococcus multilocularis microtubule associated protein 2 0.0678 0.4053 0.4051
Trichomonas vaginalis Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase 0.0022 0.0066 0.0145
Echinococcus granulosus neuropeptide receptor A26 0.0452 0.2677 0.2675
Giardia lamblia Nuclear ATP/GTP-binding protein 0.0022 0.0066 0.0097
Schistosoma mansoni hypothetical protein 0.1657 1 1
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0015 0.0024 0.0021
Echinococcus granulosus muscleblind protein 0.0147 0.0824 0.0821
Trypanosoma brucei trypanothione reductase 0.0044 0.0198 0.0668
Brugia malayi Zinc carboxypeptidase family protein 0.0022 0.0066 0.0153
Echinococcus multilocularis arginase 2, mitochondrial 0.017 0.0967 0.0964
Schistosoma mansoni carboxypeptidase N (M14 family) 0.0022 0.0066 0.0062
Loa Loa (eye worm) hypothetical protein 0.0013 0.0009 0.0017
Toxoplasma gondii zinc carboxypeptidase superfamily protein 0.0022 0.0066 0.0183
Echinococcus granulosus cytosolic carboxypeptidase protein 5 0.0022 0.0066 0.0063
Echinococcus granulosus ubiquitin conjugating enzyme E2 N 0.0496 0.2947 0.2945
Trichomonas vaginalis DNA helicase recq, putative 0.002 0.0052 0.0113
Echinococcus granulosus intermediate filament protein 0.0026 0.0091 0.0088
Plasmodium falciparum ubiquitin-conjugating enzyme E2 N, putative 0.0496 0.2947 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0038 0.0164 0.055
Trichomonas vaginalis glutathione reductase, putative 0.0015 0.0024 0.0049
Plasmodium falciparum thioredoxin reductase 0.0015 0.0024 0.003
Onchocerca volvulus 0.0093 0.0497 0.1139
Echinococcus granulosus cpg binding protein 0.0123 0.0679 0.0676
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0103 0.0556 0.1282
Schistosoma mansoni aldehyde dehydrogenase 0.0121 0.067 0.0666
Schistosoma mansoni mixed-lineage leukemia protein mll 0.003 0.0114 0.011
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0116 0.0111
Echinococcus granulosus Zinc carboxypeptidase family protein 0.0022 0.0066 0.0063
Loa Loa (eye worm) hypothetical protein 0.0022 0.0066 0.0149
Trichomonas vaginalis CMGC family protein kinase 0.0022 0.0066 0.0144
Schistosoma mansoni peptidase 0.0022 0.0066 0.0062
Giardia lamblia Nuclear ATP/GTP-binding protein 0.0022 0.0066 0.0097
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0012 0.0004 0.0001
Schistosoma mansoni ap endonuclease 0.0038 0.0164 0.0159
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0009 0.0005
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0093 0.031
Brugia malayi Zinc carboxypeptidase family protein 0.0042 0.0185 0.0426
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0012 0.0003 0.0007
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0014 0.0018 0.0034
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0022 0.0066 0.0218
Trichomonas vaginalis Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase 0.0022 0.0066 0.0145
Onchocerca volvulus 0.0026 0.0091 0.0202
Brugia malayi intermediate filament protein 0.0026 0.0091 0.021
Loa Loa (eye worm) CXXC zinc finger family protein 0.0116 0.0639 0.1472
Echinococcus granulosus subfamily M14A unassigned peptidase 0.0093 0.0497 0.0494
Echinococcus multilocularis neuropeptide receptor A26 0.0452 0.2677 0.2675
Loa Loa (eye worm) hypothetical protein 0.0032 0.013 0.0296
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0017 0.0037
Entamoeba histolytica calpain large subunit domain III containing protein 0.0019 0.0045 0.0069
Mycobacterium ulcerans phosphotyrosine protein phosphatase PtpA 0.0725 0.4335 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.013 0.0126
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0015 0.0024 0.0078
Brugia malayi Calcitonin receptor-like protein seb-1 0.0103 0.0556 0.1282
Echinococcus granulosus survival motor neuron protein 1 0.0712 0.4255 0.4253
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0022 0.0066 0.0148
Trypanosoma cruzi trypanothione reductase, putative 0.0044 0.0198 0.0668
Toxoplasma gondii exonuclease III APE 0.0038 0.0164 0.0515
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0725 0.4335 1
Trypanosoma cruzi transcription factor btf3, putative 0.0034 0.0141 0.0474
Brugia malayi Zinc carboxypeptidase family protein 0.0022 0.0066 0.0153
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0092 0.0205
Loa Loa (eye worm) hypothetical protein 0.0012 0.0006 0.001
Brugia malayi Zinc carboxypeptidase family protein 0.0022 0.0066 0.0153
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0022 0.0066 0.0218
Loa Loa (eye worm) hypothetical protein 0.0294 0.1718 0.3961
Echinococcus multilocularis dnaJ subfamily B 0.1657 1 1
Loa Loa (eye worm) hypothetical protein 0.0151 0.0851 0.196
Echinococcus granulosus bloom syndrome protein 0.002 0.0052 0.0049
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0015 0.0024 0.0078
Plasmodium vivax SET domain protein, putative 0.003 0.0116 0.0349
Schistosoma mansoni hypothetical protein 0.0032 0.013 0.0125
Echinococcus granulosus calpain 7 C02 family 0.0019 0.0045 0.0042
Brugia malayi MAP kinase sur-1 0.0022 0.0066 0.0152
Schistosoma mansoni cpg binding protein 0.0123 0.0679 0.0675
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0038 0.0164 1
Trypanosoma cruzi Enriched in surface-labeled proteome protein 12 0.0055 0.0266 0.0898
Brugia malayi Zinc carboxypeptidase family protein 0.0022 0.0066 0.0153
Loa Loa (eye worm) hypothetical protein 0.0044 0.0199 0.0456
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0015 0.0024 0.0078
Trypanosoma cruzi metallo-peptidase, Clan MC, Family M14 0.0022 0.0066 0.022
Brugia malayi exodeoxyribonuclease III family protein 0.0038 0.0164 0.0377
Echinococcus granulosus calpain A 0.0066 0.0332 0.0328
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0019 0.0045 0.0149
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0019 0.0045 0.0149
Schistosoma mansoni hypothetical protein 0.0032 0.013 0.0125
Echinococcus multilocularis ubiquitin conjugating enzyme E2 N 0.0496 0.2947 0.2945
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0248 0.1438 0.1434
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0022 0.0066 0.0181
Brugia malayi calpain family protein 1 0.0063 0.0312 0.072
Loa Loa (eye worm) hypothetical protein 0.0012 0.0003 0.0004
Schistosoma mansoni peptidase 0.0022 0.0066 0.0062
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0015 0.0024 0.0041
Schistosoma mansoni memapsin-2 (A01 family) 0.0152 0.0856 0.0853
Schistosoma mansoni hypothetical protein 0.0675 0.4032 0.4029
Echinococcus multilocularis lamin 0.0026 0.0091 0.0088
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0116 0.0111
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0015 0.0024 0.0053
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0015 0.0024 0.0078
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0038 0.0164 0.055
Loa Loa (eye worm) hypothetical protein 0.0012 0.0006 0.001
Mycobacterium tuberculosis Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase) 0.0725 0.4335 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0012 0.0006 0.0007
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0019 0.0045 0.0149
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0026 0.0092 0.0205
Leishmania major zinc carboxypeptidase, putative,metallo-peptidase, Clan MC, Family M14 0.0022 0.0066 0.022
Trypanosoma brucei metallo-peptidase, Clan MC, Family M14, putative 0.0022 0.0066 0.022
Schistosoma mansoni calpain C (C02 family) 0.0019 0.0045 0.0041
Plasmodium vivax arginase, putative 0.017 0.0967 0.3252
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0103 0.0556 0.1279
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0116 0.0112
Echinococcus granulosus microtubule associated protein 2 0.0678 0.4053 0.4051
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0053 0.0255 0.0585
Schistosoma mansoni hypothetical protein 0.0675 0.4032 0.4029
Plasmodium vivax hypothetical protein, conserved 0.0022 0.0066 0.018
Echinococcus multilocularis Zinc carboxypeptidase family protein 0.0022 0.0066 0.0063
Trypanosoma cruzi trypanothione reductase, putative 0.0015 0.0024 0.0078
Entamoeba histolytica Arginase, putative 0.017 0.0967 0.2204
Onchocerca volvulus 0.0116 0.0639 0.1468
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0092 0.0205
Brugia malayi Pre-SET motif family protein 0.0195 0.1119 0.2582
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.01 0.0539 0.1195
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0093 0.0263
Loa Loa (eye worm) hypothetical protein 0.0022 0.0066 0.0149
Echinococcus multilocularis calpain 5 0.0019 0.0045 0.0042
Leishmania major ubiquitin-conjugating enzyme e2, putative 0.0496 0.2947 1
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0019 0.0045 0.0149
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0015 0.0024 0.0078
Trichomonas vaginalis Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase 0.0022 0.0066 0.0145
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0725 0.4335 1
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0725 0.4335 1
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0164 0.0512
Schistosoma mansoni calpain-7 (C02 family) 0.0019 0.0045 0.0041
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0015 0.0024 0.0078
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0091 0.0483 0.111
Trypanosoma brucei ISWI complex protein 0.0012 0.0006 0.0017
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0017 0.004
Schistosoma mansoni family M14 non-peptidase homologue (M14 family) 0.0022 0.0066 0.0062
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0053 0.0255 0.0585
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0022 0.0066 0.0218
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0022 0.0066 0.0218
Schistosoma mansoni lamin 0.0026 0.0091 0.0087
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0018 0.0034
Trypanosoma cruzi agmatinase, putative 0.0062 0.0309 0.1044
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0066 0.0332 0.0327
Toxoplasma gondii histone lysine methyltransferase SET1 0.0221 0.1278 0.4311
Trichomonas vaginalis conserved hypothetical protein 0.017 0.0967 0.2226
Brugia malayi calpain 7 0.0019 0.0045 0.0105
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0012 0.0005 0.0011
Trypanosoma cruzi Enriched in surface-labeled proteome protein 12 0.0055 0.0266 0.0898
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.0066 0.0332 0.0328
Loa Loa (eye worm) phosphotyrosine protein phosphatase 0.0725 0.4335 1
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0015 0.0024 0.0038
Brugia malayi Cytochrome P450 family protein 0.0011 0.0001 0.0003
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0009 0.0005
Leishmania major calpain, putative,cysteine peptidase, Clan CA, family C2, putative 0.0019 0.0045 0.0149
Schistosoma mansoni myst-related protein 0.0014 0.0016 0.0011
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0019 0.0045 0.0149
Schistosoma mansoni hypothetical protein 0.0145 0.0814 0.081
Brugia malayi Low molecular weight phosphotyrosine protein phosphatase containing protein 0.0725 0.4335 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.013 0.0126
Toxoplasma gondii flagellar/basal body protein 0.0022 0.0066 0.0183
Entamoeba histolytica protein kinase, putative 0.0019 0.0047 0.0071
Trypanosoma cruzi metallo-peptidase, Clan MC, Family M14, putative 0.0022 0.0066 0.022
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0141 0.0318
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0111 0.0607 1
Brugia malayi Latrophilin receptor protein 2 0.0032 0.013 0.0299
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0145 0.0814 0.1878
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0053 0.0255 0.0252
Mycobacterium tuberculosis Probable dehydrogenase 0.01 0.0539 0.1195
Echinococcus granulosus lamin 0.0026 0.0091 0.0088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0483 0.0478
Brugia malayi hypothetical protein 0.0026 0.0093 0.0214
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0012 0.0003 0.0007
Plasmodium vivax basic transcription factor 3b, putative 0.0034 0.0141 0.0435
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0141 0.0318
Plasmodium falciparum glutathione reductase 0.0044 0.0198 0.0623
Trypanosoma cruzi arginase, putative 0.0062 0.0309 0.1044
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0026 0.0092 0.0205
Loa Loa (eye worm) hypothetical protein 0.0044 0.0199 0.0456
Loa Loa (eye worm) hypoxia-induced factor 1 0.014 0.078 0.1796
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0063 0.0312 0.0308
Echinococcus granulosus calpain 5 0.0019 0.0045 0.0042
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0053 0.0255 0.0535
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.01 0.0539 0.1195
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.013 0.0299
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0026 0.0092 0.0205
Onchocerca volvulus 0.0093 0.0497 0.1139
Onchocerca volvulus 0.0022 0.0066 0.0145
Echinococcus multilocularis thioredoxin glutathione reductase 0.0044 0.0198 0.0195
Schistosoma mansoni lamin 0.0026 0.0091 0.0087
Trypanosoma cruzi ubiquitin-conjugating enzyme E2, putative 0.0496 0.2947 1
Onchocerca volvulus 0.0145 0.0814 0.1871
Schistosoma mansoni survival motor neuron protein 0.0145 0.0814 0.081
Schistosoma mansoni microtubule-associated protein tau 0.0678 0.4053 0.4051
Loa Loa (eye worm) hypothetical protein 0.0147 0.0824 0.1899
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0026 0.0092 0.0205
Loa Loa (eye worm) hypothetical protein 0.0022 0.0066 0.0149
Brugia malayi Muscleblind-like protein 0.0147 0.0824 0.1902
Loa Loa (eye worm) zinc carboxypeptidase 0.0022 0.0066 0.0149
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0725 0.4335 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0116 0.0111

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 25.28246152 um PUBCHEM_BIOASSAY: Dose Response Confirmation for Calpain Inhibitors. (Class of assay: confirmatory) [Related pubchem assays: 1236 (Primary screen preceding this confirmatory assay.)] ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.