TDR Targets

Basic information

Technical information

TDR Targets ID: 726975
Name: 4-bromo-N-methyl-N-[[3-(3-nitrophenyl)-1,2,4- oxadiazol-5-yl]methyl]benzenesulfonamide
MW: 453.267 | Formula: C16H13BrN4O5S
H donors: 0 H acceptors: 6 LogP: 3 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: Brc1ccc(cc1)S(=O)(=O)N(Cc1onc(n1)c1cccc(c1)[N+](=O)[O-])C
InChi: 1S/C16H13BrN4O5S/c1-20(27(24,25)14-7-5-12(17)6-8-14)10-15-18-16(19-26-15)11-3-2-4-13(9-11)21(22)23/h2-9H,10H2,1H3
InChiKey: YPYVTYAPQRQJEP-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

CBKinase1_011823
CBKinase1_024223
ZINC01064902
STK322706

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0193	0.0558
Leishmania major	acetyl-CoA synthetase, putative	0.0039	0.0108	0.0345
Mycobacterium ulcerans	esterase/lipase LipP	0.0072	0.0273	0.0846
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0273	0.079
Echinococcus multilocularis	smad	0.0027	0.0047	0.0041
Loa Loa (eye worm)	AMP-binding enzyme family protein	0.0039	0.0108	0.0313
Echinococcus granulosus	neuropeptide receptor	0.0151	0.0667	0.0662
Mycobacterium ulcerans	non-ribosomal peptide synthetase MbtE	0.0039	0.0108	0.0324
Mycobacterium ulcerans	acyl-CoA synthetase	0.0056	0.0193	0.0592
Mycobacterium leprae	Probable lipase LipE	0.0072	0.0273	0.0576
Brugia malayi	acetyl-Coenzyme A synthetase 2	0.0039	0.0108	0.0297
Trypanosoma cruzi	long-chain-fatty-acid-CoA ligase, putative	0.0039	0.0108	0.034
Leishmania major	4-coumarate:coa ligase-like protein	0.0056	0.0193	0.0631
Entamoeba histolytica	hypothetical protein	0.0073	0.0277	0.0977
Mycobacterium tuberculosis	Phenyloxazoline synthase MbtB (phenyloxazoline synthetase)	0.0039	0.0108	0.0345
Plasmodium vivax	ataxin-2 like protein, putative	0.0053	0.0176	0.6358
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0046	0.0143	0.0464
Schistosoma mansoni	hypothetical protein	0.002	0.0014	0.0009
Brugia malayi	AMP-binding enzyme family protein	0.0056	0.0193	0.0542
Brugia malayi	MH2 domain containing protein	0.0027	0.0047	0.0119
Echinococcus multilocularis	zinc finger protein	0.0019	0.0009	0.0003
Brugia malayi	AMP-binding enzyme family protein	0.0039	0.0108	0.0297
Mycobacterium tuberculosis	PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.003	0.0063	0.0192
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0273	0.079
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0072	0.0273	0.0901
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0056	0.0193	0.0592
Toxoplasma gondii	HEAT repeat-containing protein	0.0029	0.0061	0.2049
Plasmodium vivax	thioredoxin reductase, putative	0.0046	0.0143	0.5146
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0073	0.0277	0.0272
Mycobacterium tuberculosis	Probable oxidoreductase	0.0117	0.0495	0.1648
Trypanosoma brucei	hypothetical protein, conserved	0.0072	0.0273	1
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0577	0.2783	1
Leishmania major	hypothetical protein, conserved	0.0053	0.0176	0.0573
Loa Loa (eye worm)	GTP-binding nuclear protein RAN/TC4	0.0022	0.0022	0.0064
Mycobacterium ulcerans	acyl-CoA synthetase	0.0039	0.0108	0.0324
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0145	0.0637	0.1829
Trypanosoma cruzi	hypothetical protein, conserved	0.0072	0.0273	0.0887
Trypanosoma cruzi	fatty acid transporter protein-like, putative	0.0624	0.3017	1
Trichomonas vaginalis	importin beta-1, putative	0.0024	0.0033	0.0098
Trichomonas vaginalis	penicillin-binding protein, putative	0.0072	0.0273	0.0962
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0577	0.2783	1
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0072	0.0273	0.0267
Schistosoma mansoni	ran	0.0022	0.0022	0.0016
Brugia malayi	MH2 domain containing protein	0.0391	0.1856	0.5365
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0072	0.0273	0.0267
Mycobacterium tuberculosis	Probable dehydrogenase	0.0105	0.0437	0.1452
Toxoplasma gondii	GTP-binding nuclear protein ran/tc4	0.0022	0.0022	0.0605
Schistosoma mansoni	importin beta-1	0.0029	0.0061	0.0055
Echinococcus granulosus	zinc finger protein	0.0019	0.0009	0.0003
Plasmodium falciparum	glutathione reductase	0.0046	0.0143	0.8093
Mycobacterium ulcerans	acyl-CoA synthetase	0.0039	0.0108	0.0324
Echinococcus multilocularis	long chain fatty acid transport protein 4	0.0624	0.3017	0.3013
Entamoeba histolytica	hypothetical protein	0.0024	0.0033	0.0098
Leishmania major	hypothetical protein, conserved	0.0072	0.0273	0.0901
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0039	0.0108	0.0324
Plasmodium falciparum	thioredoxin reductase	0.0046	0.0143	0.8093
Trypanosoma cruzi	trypanothione reductase, putative	0.0046	0.0143	0.0457
Mycobacterium ulcerans	acyl-CoA synthetase	0.0039	0.0108	0.0324
Echinococcus granulosus	Ataxin 2 N terminaldomain containing protein	0.0024	0.0032	0.0026
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0117	0.0495	0.135
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0045	0.0129
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0035	0.0088	0.0083
Trypanosoma cruzi	fatty acid transporter protein-like, putative	0.0624	0.3017	1
Schistosoma mansoni	aldehyde dehydrogenase	0.0061	0.0216	0.021
Echinococcus granulosus	Smad4	0.0027	0.0047	0.0041
Mycobacterium tuberculosis	Peptide synthetase MbtF (peptide synthase)	0.0039	0.0108	0.0345
Mycobacterium ulcerans	hypothetical protein	0.0056	0.0193	0.0592
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0072	0.0273	0.0901
Loa Loa (eye worm)	glutathione reductase	0.0046	0.0143	0.0415
Leishmania major	importin beta-1 subunit, putative	0.0024	0.0033	0.0091
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0056	0.0193	0.0674
Trypanosoma brucei	PAB1-binding protein , putative	0.0053	0.0176	0.6358
Schistosoma mansoni	bromodomain containing protein	0.0062	0.0221	0.0215
Trypanosoma cruzi	hypothetical protein, conserved	0.0072	0.0273	0.0887
Mycobacterium tuberculosis	Probable fructose-bisphosphate aldolase Fba	0.0282	0.1316	0.4416
Mycobacterium ulcerans	hypothetical protein	0.0072	0.0273	0.0846
Schistosoma mansoni	smad1 5 8 and	0.0027	0.0047	0.0041
Brugia malayi	hypothetical protein	0.0053	0.0176	0.0493
Schistosoma mansoni	hypothetical protein	0.0168	0.0749	0.0744
Loa Loa (eye worm)	hypothetical protein	0.004	0.0112	0.0323
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0061	0.0216	0.021
Echinococcus granulosus	long chain fatty acid transport protein 4	0.0624	0.3017	0.3013
Plasmodium vivax	glutathione reductase, putative	0.0046	0.0143	0.5146
Schistosoma mansoni	acetyl-CoA C-acetyltransferase	0.0022	0.0024	0.0018
Loa Loa (eye worm)	MH1 domain-containing protein	0.0027	0.0047	0.0135
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0072	0.0273	0.079
Trypanosoma brucei	long-chain-fatty-acid-CoA ligase, putative	0.0039	0.0108	0.3831
Schistosoma mansoni	survival motor neuron protein	0.0145	0.0637	0.0631
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0176	0.0509
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0056	0.0193	0.0296
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0577	0.2783	1
Mycobacterium ulcerans	phenyloxazoline synthase MbtB	0.0039	0.0108	0.0324
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0046	0.0143	0.0138
Leishmania major	long-chain-fatty-acid-CoA ligase, putative	0.0039	0.0108	0.0345
Mycobacterium ulcerans	peptide synthetase Nrp (peptide synthase)	0.0039	0.0108	0.0324
Onchocerca volvulus		0.0145	0.0637	1
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0061	0.0216	0.0664
Leishmania major	GTP-binding protein, putative	0.0022	0.0022	0.0055
Loa Loa (eye worm)	MH2 domain-containing protein	0.0027	0.0047	0.0135
Giardia lamblia	Fructose-bisphosphate aldolase	0.0577	0.2783	1
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0577	0.2783	1
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0058	0.0203	0.0198
Mycobacterium ulcerans	non-ribosomal peptide synthetase MbtF	0.0039	0.0108	0.0324
Schistosoma mansoni	FFA transport protein	0.0624	0.3017	0.3013
Mycobacterium tuberculosis	Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0039	0.0108	0.0345
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0121	0.035
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0072	0.0273	0.0846
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.0105	0.0437	0.1146
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0273	0.079
Brugia malayi	Importin beta-1 subunit	0.0029	0.0061	0.0159
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0105	0.0437	0.1452
Trypanosoma cruzi	PAB1-binding protein , putative	0.0053	0.0176	0.0564
Trichomonas vaginalis	D-aminoacylase, putative	0.0072	0.0273	0.0962
Mycobacterium ulcerans	acyl-CoA synthetase	0.0056	0.0193	0.0592
Onchocerca volvulus		0.0072	0.0273	0.312
Plasmodium vivax	acyl-CoA synthetase, putative	0.0026	0.0045	0.1449
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0022	0.0022	0.0054
Mycobacterium ulcerans	acyl-CoA synthetase	0.0039	0.0108	0.0324
Plasmodium falciparum	ataxin-2 like protein, putative	0.0053	0.0176	1
Echinococcus granulosus	acetyl coenzyme A synthetase cytoplasmic	0.0039	0.0108	0.0102
Brugia malayi	MH1 domain containing protein	0.0027	0.0047	0.0119
Schistosoma mansoni	TGF-beta signal transducer Smad2	0.0027	0.0047	0.0041
Plasmodium falciparum	acyl-CoA synthetase	0.0026	0.0045	0.2279
Mycobacterium tuberculosis	Probable lipase LipE	0.0072	0.0273	0.0901
Toxoplasma gondii	propionate-CoA ligase	0.0039	0.0108	0.3831
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0108	0.0313
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0061	0.0216	0.0664
Schistosoma mansoni	transcription factor LCR-F1	0.0073	0.0277	0.0272
Mycobacterium tuberculosis	Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0039	0.0108	0.0345
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0273	0.079
Mycobacterium tuberculosis	Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase	0.0039	0.0108	0.0345
Onchocerca volvulus		0.0072	0.0273	0.312
Brugia malayi	AMP-binding enzyme family protein	0.0056	0.0193	0.0542
Brugia malayi	MH2 domain containing protein	0.0027	0.0047	0.0119
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0072	0.0273	0.0901
Mycobacterium tuberculosis	Probable esterase LipL	0.0072	0.0273	0.0901
Toxoplasma gondii	ABC1 family protein	0.0072	0.0273	1
Mycobacterium tuberculosis	Conserved protein	0.0072	0.0273	0.0901
Plasmodium vivax	acetyl-CoA synthetase, putative	0.0039	0.0108	0.3831
Brugia malayi	beta-lactamase family protein	0.0072	0.0273	0.0775
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0024	0.0033	0.0098
Loa Loa (eye worm)	oxidoreductase	0.0039	0.0108	0.0313
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0022	0.0022	0.0054
Brugia malayi	PHD-finger family protein	0.0024	0.0035	0.0085
Schistosoma mansoni	hypothetical protein	0.0168	0.0749	0.0744
Echinococcus multilocularis	neuropeptide receptor	0.0151	0.0667	0.0662
Brugia malayi	Bromodomain containing protein	0.0073	0.0277	0.0787
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0577	0.2783	1
Entamoeba histolytica	long-chain-fatty-acid--CoA ligase, putative	0.0039	0.0108	0.0369
Schistosoma mansoni	smad1 5 8 and	0.0027	0.0047	0.0041
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0039	0.0108	0.0297
Echinococcus granulosus	smad	0.0027	0.0047	0.0041
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0577	0.2783	1
Giardia lamblia	GTP-binding nuclear protein RAN/TC4	0.0022	0.0022	0.0058
Echinococcus multilocularis	importin subunit beta 1	0.0029	0.0061	0.0055
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0056	0.0193	0.0592
Schistosoma mansoni	microtubule-associated protein tau	0.203	1	1
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0056	0.0193	0.0592
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0045	0.0129
Toxoplasma gondii	thioredoxin reductase	0.0046	0.0143	0.5146
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0045	0.0129
Schistosoma mansoni	aldehyde dehydrogenase	0.0061	0.0216	0.021
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0061	0.0216	0.0664
Mycobacterium ulcerans	acyl-CoA synthetase	0.0039	0.0108	0.0324
Brugia malayi	GTP-binding nuclear protein RAN/TC4	0.0022	0.0022	0.0047
Entamoeba histolytica	hypothetical protein	0.0073	0.0277	0.0977
Toxoplasma gondii	AMP-binding enzyme domain-containing protein	0.0039	0.0108	0.3831
Schistosoma mansoni	hypothetical protein	0.0145	0.0637	0.0631
Trypanosoma brucei	trypanothione reductase	0.0046	0.0143	0.5146
Brugia malayi	AMP-binding enzyme family protein	0.0039	0.0108	0.0297
Mycobacterium leprae	possible long-chain acyl-CoA synthase	0.0615	0.2972	1
Mycobacterium ulcerans	bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase	0.0039	0.0108	0.0324
Mycobacterium ulcerans	acyl-CoA synthetase	0.0039	0.0108	0.0324
Mycobacterium ulcerans	long-chain-acyl-CoA synthetase	0.0654	0.3166	1
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0117	0.0495	0.1648
Entamoeba histolytica	hypothetical protein	0.0073	0.0277	0.0977
Echinococcus granulosus	GTP binding nuclear protein Ran	0.0022	0.0022	0.0016
Mycobacterium tuberculosis	Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase)	0.0039	0.0108	0.0345
Plasmodium falciparum	acetyl-CoA synthetase, putative	0.0039	0.0108	0.6025
Loa Loa (eye worm)	MH2 domain-containing protein	0.0391	0.1856	0.5373
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0056	0.0193	0.0631
Brugia malayi	Smad1	0.0027	0.0047	0.0119
Mycobacterium tuberculosis	Conserved protein	0.0072	0.0273	0.0901
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0026	0.0045	0.0131
Echinococcus granulosus	TGF beta signal transducer SmadC	0.0027	0.0047	0.0041
Mycobacterium ulcerans	fructose-bisphosphate aldolase	0.0282	0.1316	0.4146
Brugia malayi	beta-lactamase family protein	0.0072	0.0273	0.0775
Trypanosoma brucei	GTP-binding nuclear protein rtb2, putative	0.0022	0.0022	0.0605
Mycobacterium leprae	conserved hypothetical protein	0.0072	0.0273	0.0576
Onchocerca volvulus		0.0072	0.0273	0.312
Onchocerca volvulus		0.0056	0.0193	0.1603
Schistosoma mansoni	hypothetical protein	0.0314	0.1474	0.1469
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0273	0.079
Plasmodium falciparum	importin beta, putative	0.0029	0.0061	0.3223
Leishmania major	trypanothione reductase	0.0046	0.0143	0.0464
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0193	0.0558
Entamoeba histolytica	hypothetical protein	0.0073	0.0277	0.0977
Toxoplasma gondii	aldehyde dehydrogenase	0.0061	0.0216	0.7851
Echinococcus multilocularis	GTP binding nuclear protein Ran	0.0022	0.0022	0.0016
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0056	0.0193	0.0674
Echinococcus multilocularis	acetyl coenzyme A synthetase, cytoplasmic	0.0039	0.0108	0.0102
Schistosoma mansoni	Smad4	0.0027	0.0047	0.0041
Leishmania major	fatty acid transporter protein-like protein	0.0615	0.2972	1
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0058	0.0203	0.0198
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0061	0.0216	0.0707
Mycobacterium ulcerans	O-succinylbenzoic acid--CoA ligase	0.0039	0.0108	0.0324
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0018	0.0006	0.5
Mycobacterium ulcerans	lipase LipD	0.0072	0.0273	0.0846
Trichomonas vaginalis	ran, putative	0.0022	0.0022	0.0058
Trichomonas vaginalis	D-aminoacylase, putative	0.0072	0.0273	0.0962
Loa Loa (eye worm)	hypothetical protein	0.0037	0.01	0.029
Trichomonas vaginalis	esterase, putative	0.0072	0.0273	0.0962
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0061	0.0175
Leishmania major	acetyl-CoA synthetase, putative	0.0039	0.0108	0.0345
Loa Loa (eye worm)	thioredoxin reductase	0.0046	0.0143	0.0415
Echinococcus granulosus	fetal alzheimer antigen falz	0.0022	0.0024	0.0018
Leishmania major	4-coumarate:coa ligase-like protein	0.0056	0.0193	0.0631
Mycobacterium ulcerans	acyl-CoA synthetase	0.0039	0.0108	0.0324
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0056	0.0193	0.0631
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0073	0.0277	0.0272
Plasmodium falciparum	GTP-binding nuclear protein RAN/TC4	0.0022	0.0022	0.0952
Trypanosoma cruzi	importin beta-1 subunit, putative	0.0024	0.0033	0.009
Mycobacterium tuberculosis	Conserved protein	0.0072	0.0273	0.0901
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0072	0.0273	0.0775
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0108	0.0313
Loa Loa (eye worm)	beta-lactamase	0.0072	0.0273	0.079
Schistosoma mansoni	acetyl-CoA synthetase	0.0039	0.0108	0.0102
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0117	0.0495	0.1648
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0577	0.2783	1
Trichomonas vaginalis	penicillin-binding protein, putative	0.0072	0.0273	0.0962
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0056	0.0193	0.0592
Entamoeba histolytica	acyl-coA synthetase, putative	0.0056	0.0193	0.0674
Brugia malayi	beta-lactamase	0.0072	0.0273	0.0775
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0273	0.079
Mycobacterium tuberculosis	P-hydroxybenzoyl-AMP ligase FadD22	0.0039	0.0108	0.0345
Brugia malayi	Bromodomain containing protein	0.0037	0.01	0.0273
Trypanosoma brucei	importin beta-1 subunit, putative	0.0029	0.0061	0.2049
Mycobacterium ulcerans	acetyl-CoA synthetase	0.0039	0.0108	0.0324
Mycobacterium tuberculosis	Probable peptide synthetase Nrp (peptide synthase)	0.0039	0.0108	0.0345
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0039	0.0108	0.0345
Loa Loa (eye worm)	PHD-finger family protein	0.002	0.0014	0.0042
Brugia malayi	Thioredoxin reductase	0.0046	0.0143	0.0399
Mycobacterium tuberculosis	Probable hydrolase	0.0072	0.0273	0.0901
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0061	0.0216	0.0707
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0026	0.0045	0.0123
Schistosoma mansoni	ran	0.0022	0.0022	0.0016
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0024	0.0033	0.0098
Trypanosoma cruzi	long-chain-fatty-acid-CoA ligase, putative	0.0039	0.0108	0.034
Brugia malayi	MH1 domain containing protein	0.0027	0.0047	0.0119
Echinococcus multilocularis	TGF beta signal transducer SmadC	0.0027	0.0047	0.0041
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0045	0.0129
Plasmodium vivax	importin-beta 2, putative	0.0029	0.0061	0.2049
Plasmodium vivax	hypothetical protein, conserved	0.0072	0.0273	1
Echinococcus granulosus	beta LACTamase domain containing family member	0.0072	0.0273	0.0267
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0056	0.0193	0.0296
Toxoplasma gondii	LsmAD domain-containing protein	0.0053	0.0176	0.6358
Trypanosoma brucei	acetyl-CoA synthetase, putative	0.0039	0.0108	0.3831
Plasmodium vivax	GTP-binding nuclear protein RAN/TC4, putative	0.0022	0.0022	0.0605
Echinococcus granulosus	mothers against decapentaplegic 5	0.0027	0.0047	0.0041
Treponema pallidum	fructose-bisphosphate aldolase	0.0577	0.2783	1
Trichomonas vaginalis	antibiotic synthetase, putative	0.0039	0.0108	0.0369
Schistosoma mansoni	neuropeptide receptor	0.0151	0.0667	0.0662
Echinococcus granulosus	snurportin 1	0.0314	0.1474	0.1469
Echinococcus granulosus	survival motor neuron protein 1	0.0713	0.3455	0.3451
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0072	0.0273	0.0267
Loa Loa (eye worm)	hypothetical protein	0.0713	0.3455	1
Echinococcus multilocularis	snurportin 1	0.0314	0.1474	0.1469
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0577	0.2783	1
Echinococcus multilocularis	geminin	0.0168	0.0749	0.0744
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0018	0.0006	0.0017
Mycobacterium ulcerans	acyl-CoA synthetase	0.0056	0.0193	0.0592
Loa Loa (eye worm)	transcription factor SMAD2	0.0391	0.1856	0.5373
Mycobacterium ulcerans	acyl-CoA synthetase	0.0039	0.0108	0.0324
Entamoeba histolytica	Ran family GTPase	0.0022	0.0022	0.0058
Loa Loa (eye worm)	Smad1	0.0027	0.0047	0.0135
Echinococcus granulosus	importin subunit beta 1	0.0029	0.0061	0.0055
Brugia malayi	AMP-binding enzyme family protein	0.0654	0.3166	0.9161
Echinococcus multilocularis	microtubule associated protein 2	0.203	1	1
Echinococcus multilocularis	Smad4	0.0027	0.0047	0.0041
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0105	0.0437	0.1452
Brugia malayi	hypothetical protein	0.0713	0.3455	1
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD6 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0615	0.2972	1
Plasmodium falciparum	ataxin-2 like protein, putative	0.0053	0.0176	1
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.0026	0.0045	0.5
Schistosoma mansoni	hypothetical protein	0.0024	0.0032	0.0026
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0061	0.0216	0.021
Trichomonas vaginalis	antibiotic synthetase, putative	0.0039	0.0108	0.0369
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0035	0.0088	0.0083
Mycobacterium ulcerans	beta-lactamase	0.0072	0.0273	0.0846
Loa Loa (eye worm)	AMP-binding enzyme family protein	0.0654	0.3166	0.9162
Brugia malayi	hypothetical protein	0.0034	0.0083	0.0224
Brugia malayi	AMP-binding enzyme family protein	0.0039	0.0108	0.0297
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0314	0.1474	0.4266
Trypanosoma brucei	importin beta-1 subunit, putative	0.0029	0.0061	0.2049
Mycobacterium tuberculosis	Probable lipase LipD	0.0072	0.0273	0.0901
Schistosoma mansoni	smad	0.0027	0.0047	0.0041
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0461	0.2205	0.7415
Brugia malayi	glutathione reductase	0.0046	0.0143	0.0399
Echinococcus multilocularis	fetal alzheimer antigen, falz	0.0022	0.0024	0.0018
Toxoplasma gondii	Acetyl-coenzyme A synthetase 2, putative	0.0039	0.0108	0.3831
Trichomonas vaginalis	D-aminoacylase, putative	0.0072	0.0273	0.0962
Echinococcus granulosus	thioredoxin glutathione reductase	0.0046	0.0143	0.0138
Trypanosoma cruzi	PAB1-binding protein , putative	0.0053	0.0176	0.0564
Echinococcus multilocularis	G protein coupled receptor 139	0.0151	0.0667	0.0662
Echinococcus multilocularis	mothers against decapentaplegic 5	0.0027	0.0047	0.0041
Trypanosoma cruzi	acetyl-CoA synthetase, putative	0.0039	0.0108	0.034
Brugia malayi	AMP-binding enzyme family protein	0.0056	0.0193	0.0542
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0577	0.2783	1
Brugia malayi	hypothetical protein	0.0073	0.0277	0.0787
Mycobacterium leprae	Probable fructose bisphosphate aldolase Fba	0.0282	0.1316	0.4217
Schistosoma mansoni	hypothetical protein	0.0073	0.0277	0.0272
Echinococcus multilocularis	Ataxin 2, N terminal,domain containing protein	0.0024	0.0032	0.0026
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0577	0.2783	1
Trypanosoma cruzi	acetyl-CoA synthetase, putative	0.0039	0.0108	0.034
Echinococcus granulosus	geminin	0.0168	0.0749	0.0744
Leishmania major	4-coumarate:coa ligase-like protein	0.0056	0.0193	0.0631
Mycobacterium tuberculosis	Probable reductase	0.0105	0.0437	0.1452
Schistosoma mansoni	smad1 5 8 and	0.0027	0.0047	0.0041
Mycobacterium tuberculosis	Peptide synthetase MbtE (peptide synthase)	0.0039	0.0108	0.0345
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0193	0.0558
Schistosoma mansoni	zinc finger protein	0.0019	0.0009	0.0003
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0045	0.0129
Mycobacterium tuberculosis	Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0039	0.0108	0.0345
Echinococcus multilocularis	survival motor neuron protein 1	0.0713	0.3455	0.3451
Brugia malayi	RNA, U transporter 1	0.0084	0.033	0.094
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0105	0.0437	0.1452
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0105	0.0437	0.1452
Loa Loa (eye worm)	hypothetical protein	0.0069	0.0257	0.0743

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Search by Saint Jude

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 726975