Detailed information for compound 729353

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 423.569 | Formula: C21H33N3O4S
  • H donors: 1 H acceptors: 2 LogP: 1.81 Rotable bonds: 12
    Rule of 5 violations (Lipinski): 1
  • SMILES: CSCCC(=O)N1CCC(CC1)Oc1cc(ccc1OC)C(=O)NCCN(C)C
  • InChi: 1S/C21H33N3O4S/c1-23(2)13-10-22-21(26)16-5-6-18(27-3)19(15-16)28-17-7-11-24(12-8-17)20(25)9-14-29-4/h5-6,15,17H,7-14H2,1-4H3,(H,22,26)
  • InChiKey: TYSGABKIIWNWPF-UHFFFAOYSA-N  


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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii thioredoxin reductase 0.0054 0.0486 0.5544
Brugia malayi Peptidase family M1 containing protein 0.0024 0.0177 0.0323
Trichomonas vaginalis pyruvate kinase, putative 0.0035 0.0292 0.0516
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0039 0.0326 0.259
Trichomonas vaginalis inositol monophosphatase, putative 0.0036 0.0301 0.0532
Trypanosoma brucei Importin-beta N-terminal domain/HEAT-like repeat, putative 0.0017 0.0101 0.0392
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0024 0.0176 0.1127
Trichomonas vaginalis glucosylceramidase, putative 0.0348 0.3568 0.6506
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0065 0.0608 0.0598
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0065 0.0608 0.5138
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.015 0.0256
Toxoplasma gondii histone lysine methyltransferase SET1 0.0056 0.0513 0.5857
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0063 0.0581 0.0571
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0122 0.0606
Onchocerca volvulus 0.0035 0.029 0.0531
Loa Loa (eye worm) aminopeptidase N 0.0069 0.0648 0.0648
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0039 0.0326 0.2151
Schistosoma mansoni cpg binding protein 0.0029 0.0221 0.0211
Toxoplasma gondii pyruvate kinase PyKII 0.0018 0.0112 0.1148
Mycobacterium tuberculosis Conserved protein 0.0035 0.029 0.1237
Echinococcus granulosus importin 5 0.0017 0.0101 0.0091
Plasmodium vivax glutathione reductase, putative 0.0054 0.0486 0.5042
Toxoplasma gondii HEAT repeat-containing protein 0.009 0.0866 1
Brugia malayi hypothetical protein 0.0024 0.0177 0.0323
Loa Loa (eye worm) hypothetical protein 0.0035 0.029 0.029
Schistosoma mansoni hypothetical protein 0.0027 0.0205 0.0195
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0069 0.0648 0.1166
Plasmodium vivax SET domain protein, putative 0.0064 0.0595 0.6459
Loa Loa (eye worm) importin-beta domain-containing protein 0.0017 0.0101 0.0101
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0019 0.0118 0.0559
Leishmania major GTP-binding protein, putative 0.0066 0.0617 0.5231
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0326 0.0578
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0024 0.0177 0.0167
Loa Loa (eye worm) hypothetical protein 0.0009 0.0014 0.0014
Trichomonas vaginalis glucosylceramidase, putative 0.0348 0.3568 0.6506
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0009 0.0021 0.0011
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0035 0.0292 0.1246
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.029 0.0281
Loa Loa (eye worm) DIX domain-containing protein 0.0009 0.0014 0.0014
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.029 0.0513
Trypanosoma brucei pyruvate kinase 1 0.0035 0.0292 0.226
Loa Loa (eye worm) hypothetical protein 0.0035 0.029 0.029
Schistosoma mansoni dishevelled 0.0009 0.0014 0.0004
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.0024 0.0177 0.0614
Echinococcus granulosus importin subunit beta 1 0.009 0.0866 0.0857
Echinococcus multilocularis cpg binding protein 0.003 0.0238 0.0228
Mycobacterium leprae Probable pyruvate kinase PykA 0.0035 0.0292 0.2102
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0039 0.0326 0.2287
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0039 0.0326 0.259
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0326 0.0578
Entamoeba histolytica hypothetical protein 0.0109 0.1059 1
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0036 0.0301 0.1071
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.002 0.0131 0.0307
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0019 0.0118 0.0559
Leishmania major phosphatidylinositol 3-kinase, putative 0.0039 0.0326 0.2287
Echinococcus multilocularis muscleblind protein 1 0.0158 0.158 0.1572
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.029 0.0513
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.015 0.0256
Trypanosoma brucei variant surface glycoprotein (VSG), putative 0.0111 0.1087 1
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0032 0.0261 0.111
Echinococcus granulosus aminopeptidase N 0.0069 0.0648 0.0638
Loa Loa (eye worm) tumor suppressor 0.032 0.3271 0.3271
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0137 0.1353 1
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.002 0.0131 0.0533
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0039 0.0326 0.0595
Echinococcus multilocularis Pleckstrin G protein, interacting region 0.0009 0.0014 0.0004
Onchocerca volvulus 0.0069 0.0648 0.1218
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0069 0.0648 0.0638
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0052 0.0468 0.0458
Trypanosoma cruzi importin beta-1 subunit, putative 0.0073 0.0687 0.5876
Mycobacterium ulcerans glutaminase 0.0268 0.2729 1
Echinococcus multilocularis pyruvate kinase 0.0018 0.0112 0.0102
Loa Loa (eye worm) hypothetical protein 0.0025 0.018 0.018
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0039 0.0326 0.2151
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0022 0.015 0.014
Loa Loa (eye worm) TAR-binding protein 0.0062 0.057 0.057
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0024 0.0177 0.0614
Plasmodium vivax thioredoxin reductase, putative 0.0054 0.0486 0.5042
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0039 0.0326 0.2355
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0065 0.0608 0.5291
Loa Loa (eye worm) hypothetical protein 0.0035 0.0292 0.0292
Schistosoma mansoni cpg binding protein 0.003 0.0238 0.0228
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.0131 0.0687
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0017 0.0098 0.0088
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0024 0.0177 0.0614
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0024 0.0177 0.0167
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.029 0.1237
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0326 0.0578
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0122 0.0113
Echinococcus granulosus pyruvate kinase 0.0018 0.0112 0.0102
Mycobacterium leprae Probable lipase LipE 0.0035 0.029 0.2087
Echinococcus granulosus transcription factor Dp 1 0.0038 0.0319 0.0309
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0326 0.0578
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0039 0.0326 0.0317
Trichomonas vaginalis glucosylceramidase, putative 0.0348 0.3568 0.6506
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0111 0.1087 1
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0024 0.0177 0.1001
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0122 0.0606
Onchocerca volvulus 0.0024 0.0177 0.0313
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0066 0.0617 0.0617
Echinococcus granulosus regulator of G protein signaling 7 0.0009 0.0014 0.0004
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0111 0.1087 1
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0039 0.0326 0.2355
Schistosoma mansoni DNA polymerase eta 0.0019 0.0122 0.0113
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0608 0.5052
Loa Loa (eye worm) phosphatidylinositol 3 0.0039 0.0326 0.0326
Echinococcus multilocularis segment polarity protein dishevelled 0.0009 0.0014 0.0004
Echinococcus multilocularis pyruvate kinase 0.0035 0.0292 0.0283
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0111 0.1087 1
Toxoplasma gondii FATC domain-containing protein 0.0053 0.0477 0.5436
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0326 0.0578
Toxoplasma gondii HEAT repeat-containing protein 0.0017 0.0101 0.1013
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0066 0.0617 0.0607
Echinococcus granulosus leukotriene A 4 hydrolase 0.0024 0.0177 0.0167
Entamoeba histolytica Ran family GTPase 0.0066 0.0617 0.5386
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0122 0.0228
Mycobacterium ulcerans aminopeptidase N PepN 0.0024 0.0177 0.0615
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0179 0.1797 0.3427
Echinococcus multilocularis inositol monophosphatase 1 0.0036 0.0301 0.0291
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0137 0.1353 0.5928
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0066 0.0617 0.6744
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0039 0.0326 0.2151
Echinococcus granulosus cpg binding protein 0.003 0.0238 0.0228
Loa Loa (eye worm) hypothetical protein 0.0024 0.0177 0.0177
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0122 0.0606
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0024 0.0177 0.1001
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0066 0.0617 0.1126
Brugia malayi hypothetical protein 0.0009 0.0014 0.0026
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0326 0.0578
Brugia malayi CXXC zinc finger family protein 0.0029 0.0221 0.0403
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0122 0.0205
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.029 0.1237
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.029 0.053
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0069 0.0648 0.0638
Brugia malayi FAT domain containing protein 0.0017 0.0098 0.0179
Trichomonas vaginalis glucosylceramidase, putative 0.053 0.5479 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0177 0.0177
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0036 0.0301 1
Mycobacterium ulcerans lipase LipD 0.0035 0.029 0.1031
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0052 0.0468 0.0458
Loa Loa (eye worm) pyruvate kinase 0.0035 0.0292 0.0292
Echinococcus granulosus pyruvate kinase 0.0018 0.0112 0.0102
Loa Loa (eye worm) peptidase family M1 containing protein 0.0024 0.0177 0.0177
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0019 0.0118 0.0396
Mycobacterium tuberculosis Conserved protein 0.0035 0.029 0.1237
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0039 0.0326 0.2287
Schistosoma mansoni tar DNA-binding protein 0.0062 0.057 0.0561
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0065 0.0608 0.1109
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0301 0.2346
Echinococcus granulosus pyruvate kinase 0.0035 0.0292 0.0283
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0009 0.0014 0.0026
Schistosoma mansoni glutaminase 0.0268 0.2729 0.2721
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.029 0.2241
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0301 0.2033
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0122 0.0606
Brugia malayi Pyruvate kinase, alpha/beta domain containing protein 0.0011 0.0034 0.0062
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0326 0.0578
Loa Loa (eye worm) kap beta 3 protein 0.0017 0.0101 0.0101
Brugia malayi Pre-SET motif family protein 0.0444 0.4575 0.835
Echinococcus granulosus segment polarity protein dishevelled 0.0009 0.0014 0.0004
Plasmodium falciparum thioredoxin reductase 0.0054 0.0486 0.5042
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0069 0.0648 0.0638
Echinococcus multilocularis pyruvate kinase 0.0018 0.0112 0.0102
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0122 0.005
Trichomonas vaginalis PIKK family atypical protein kinase 0.0014 0.0072 0.0114
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0066 0.0617 0.5147
Brugia malayi Thioredoxin reductase 0.0054 0.0486 0.0888
Entamoeba histolytica protein kinase rad3, putative 0.0022 0.015 0.0516
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0301 0.0532
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0046 0.0399 0.2906
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0326 0.0578
Brugia malayi glutaminase DH11.1 0.0268 0.2729 0.498
Loa Loa (eye worm) hypothetical protein 0.0158 0.158 0.158
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0326 0.0578
Mycobacterium tuberculosis Probable dehydrogenase 0.0123 0.121 0.5294
Echinococcus multilocularis snurportin 1 0.0962 1 1
Leishmania major trypanothione reductase 0.0054 0.0486 0.3911
Trichomonas vaginalis glucosylceramidase, putative 0.0348 0.3568 0.6506
Echinococcus multilocularis segment polarity protein dishevelled 0.0009 0.0014 0.0004
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0326 0.0578
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0122 0.0606
Treponema pallidum exodeoxyribonuclease (exoA) 0.002 0.0131 1
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0022 0.015 0.0516
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0122 0.0606
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0019 0.0118 0.0215
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0019 0.0118 0.0108
Trypanosoma cruzi aminopeptidase, putative 0.0024 0.0177 0.0614
Echinococcus multilocularis importin subunit beta 1 0.009 0.0866 0.0857
Schistosoma mansoni hypothetical protein 0.0109 0.1059 0.105
Loa Loa (eye worm) histone methyltransferase 0.0011 0.0039 0.0039
Echinococcus multilocularis pyruvate kinase 0.0028 0.0214 0.0204
Loa Loa (eye worm) pyruvate kinase 0.0035 0.0292 0.0292
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0052 0.0468 0.0458
Brugia malayi beta-lactamase family protein 0.0035 0.029 0.053
Schistosoma mansoni importin beta-1 0.009 0.0866 0.0857
Brugia malayi glutathione reductase 0.0054 0.0486 0.0888
Loa Loa (eye worm) hypothetical protein 0.0035 0.029 0.029
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.015 0.0256
Brugia malayi hypothetical protein 0.0027 0.0205 0.0375
Loa Loa (eye worm) hypothetical protein 0.0022 0.015 0.015
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0022 0.015 0.0274
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.029 0.0513
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.015 0.0256
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0014 0.0066 0.012
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0019 0.0118 0.0108
Trichomonas vaginalis ran, putative 0.0066 0.0617 0.1109
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.002 0.0131 0.0371
Echinococcus multilocularis leukotriene A 4 hydrolase 0.0024 0.0177 0.0167
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.029 0.0513
Trichomonas vaginalis glucosylceramidase, putative 0.053 0.5479 1
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0111 0.1087 1
Echinococcus multilocularis protein quaking 0.0027 0.0205 0.0195
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0019 0.0118 0.0559
Loa Loa (eye worm) hypothetical protein 0.0045 0.0393 0.0393
Brugia malayi Importin beta-1 subunit 0.009 0.0866 0.1581
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0122 0.0606
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0122 0.0496
Chlamydia trachomatis pyruvate kinase 0.0035 0.0292 1
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.053 0.5479 0.5479
Onchocerca volvulus 0.0035 0.029 0.0531
Loa Loa (eye worm) hypothetical protein 0.0009 0.0014 0.0014
Echinococcus granulosus regulator of G protein signaling 7 0.0009 0.0014 0.0004
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0326 0.0578
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0064 0.0595 0.0585
Treponema pallidum NADH oxidase 0.0019 0.0118 0.8908
Trypanosoma brucei calpain, putative 0.0111 0.1087 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0326 0.0578
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0122 0.0223
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0009 0.0021 0.0011
Schistosoma mansoni tar DNA-binding protein 0.0062 0.057 0.0561
Plasmodium falciparum glutathione reductase 0.0054 0.0486 0.5042
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0019 0.0118 0.0173
Toxoplasma gondii aminopeptidase N protein 0.0024 0.0177 0.1913
Leishmania major aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0069 0.0648 0.5545
Echinococcus granulosus pyruvate kinase 0.0018 0.0112 0.0102
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0131 0.0136
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0123 0.121 0.5294
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0065 0.0608 0.0608
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0123 0.121 0.5294
Mycobacterium tuberculosis Probable oxidoreductase 0.0137 0.1353 0.5928
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.057 0.057
Toxoplasma gondii pyruvate kinase PyK1 0.0035 0.0292 0.3265
Echinococcus granulosus mixed lineage leukemia protein mll 0.0009 0.0021 0.0011
Brugia malayi Peptidase family M1 containing protein 0.0069 0.0648 0.1182
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0073 0.0687 0.1239
Echinococcus multilocularis regulator of G protein signaling 7 0.0009 0.0014 0.0004
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0069 0.0648 0.5545
Schistosoma mansoni inositol monophosphatase 0.0036 0.0301 0.0291
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0131 0.0221
Schistosoma mansoni fkbp-rapamycin associated protein 0.0022 0.015 0.014
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0066 0.0617 0.5418
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0111 0.1087 1
Giardia lamblia GTOR 0.0039 0.0326 0.4243
Plasmodium falciparum importin beta, putative 0.009 0.0866 1
Giardia lamblia Pyruvate kinase 0.0035 0.0292 0.3572
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0039 0.0326 0.2287
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0326 0.0578
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0053 0.0477 0.3708
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0011 0.0039 0.0029
Schistosoma mansoni tar DNA-binding protein 0.0062 0.057 0.0561
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0024 0.0177 0.0777
Plasmodium vivax pyruvate kinase, putative 0.0035 0.0292 0.2506
Echinococcus granulosus dnaJ subfamily B 0.0407 0.4182 0.4176
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0064 0.0595 0.0585
Entamoeba histolytica exodeoxyribonuclease III, putative 0.002 0.0131 0.0316
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0122 0.005
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0064 0.0595 0.6817
Trichomonas vaginalis mercuric reductase, putative 0.0019 0.0118 0.0197
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.015 0.0256
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0131 0.0395
Schistosoma mansoni ap endonuclease 0.002 0.0131 0.0121
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.0045 0.0393 0.2836
Echinococcus granulosus protein quaking 0.0027 0.0205 0.0195
Brugia malayi kap beta 3 protein 0.0017 0.0101 0.0183
Echinococcus granulosus tar DNA binding protein 0.0062 0.057 0.0561
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.057 0.1041
Onchocerca volvulus Pyruvate kinase homolog 0.0035 0.0292 0.0535
Loa Loa (eye worm) hypothetical protein 0.0017 0.0098 0.0098
Brugia malayi Pyruvate kinase, muscle isozyme 0.0035 0.0292 0.0534
Mycobacterium ulcerans hypothetical protein 0.0035 0.029 0.1031
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.0024 0.0177 0.0167
Leishmania major DNA polymerase kappa, putative 0.0019 0.0122 0.0222
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0444 0.4575 0.4575
Brugia malayi Temporarily assigned gene name protein 44 0.0027 0.0205 0.0375
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0122 0.0606
Loa Loa (eye worm) hypothetical protein 0.009 0.0866 0.0866
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0064 0.0595 0.0585
Trypanosoma brucei trypanothione reductase 0.0054 0.0486 0.415
Loa Loa (eye worm) hypothetical protein 0.0024 0.0176 0.0176
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0019 0.0118 0.0173
Echinococcus granulosus pyruvate kinase 0.0035 0.0292 0.0283
Trypanosoma cruzi pyruvate kinase 2, putative 0.0035 0.0292 0.1802
Trypanosoma cruzi aminopeptidase, putative 0.0069 0.0648 0.5467
Leishmania major phosphatidylinositol kinase related protein, putative 0.0039 0.0327 0.2295
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0019 0.0118 0.0396
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0073 0.0687 0.1239
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0039 0.0326 0.0317
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0131 0.0221
Trypanosoma brucei Aminopeptidase M1, putative 0.0069 0.0648 0.572
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0326 0.0578
Echinococcus multilocularis thioredoxin glutathione reductase 0.0054 0.0486 0.0477
Echinococcus multilocularis translational activator gcn1 0.0017 0.0101 0.0091
Echinococcus granulosus transportin 1 0.0017 0.0101 0.0091
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0052 0.0468 0.0458
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0065 0.0608 0.0598
Brugia malayi Muscleblind-like protein 0.0158 0.158 0.2885
Trichomonas vaginalis glutathione reductase, putative 0.0019 0.0118 0.0197
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0069 0.0648 0.0638
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0032 0.0261 0.1872
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0061 0.0564 0.0554
Brugia malayi Peptidase family M1 containing protein 0.0069 0.0648 0.1182
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0221 0.0221
Brugia malayi regulator of G-protein signaling egl-10 0.0009 0.0014 0.0026
Toxoplasma gondii HEAT repeat-containing protein 0.0017 0.0101 0.1013
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0019 0.0118 0.0173
Echinococcus multilocularis serine protein kinase ATM 0.0053 0.0477 0.0468
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0109 0.1059 0.105
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0122 0.0205
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.029 0.1237
Brugia malayi RNA, U transporter 1 0.0256 0.2607 0.4757
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0039 0.0327 0.2159
Toxoplasma gondii aminopeptidase N, putative 0.0024 0.0177 0.1913
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0301 0.0532
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0069 0.0648 0.0638
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0122 0.0223
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0122 0.0113
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0017 0.0098 0.0088
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.029 0.0513
Schistosoma mansoni ap endonuclease 0.002 0.0131 0.0121
Trichomonas vaginalis esterase, putative 0.0035 0.029 0.0513
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0021 0.0011
Loa Loa (eye worm) glutathione reductase 0.0054 0.0486 0.0486
Brugia malayi hypothetical protein 0.0009 0.0014 0.0026
Entamoeba histolytica hypothetical protein 0.0073 0.0687 0.6124
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0326 0.0578
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0019 0.0118 0.0223
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0019 0.0118 0.3694
Schistosoma mansoni hypothetical protein 0.0529 0.547 0.5465
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0066 0.0617 0.6744
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0019 0.0118 0.0173
Trypanosoma brucei aminopeptidase, putative 0.0024 0.0177 0.1139
Trypanosoma brucei ULK family serine/threonine-protein kinase, putative 0.0017 0.0101 0.0392
Toxoplasma gondii ABC1 family protein 0.0035 0.029 0.3242
Loa Loa (eye worm) hypothetical protein 0.0045 0.0393 0.0393
Schistosoma mansoni cpg binding protein 0.003 0.0238 0.0228
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0019 0.0118 0.0396
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.015 0.0256
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0039 0.0326 0.259
Trichomonas vaginalis glucosylceramidase, putative 0.053 0.5479 1
Plasmodium falciparum M1-family alanyl aminopeptidase 0.0024 0.0177 0.1001
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0111 0.1087 1
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0019 0.0118 0.0108
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.029 0.1237
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0608 0.5329
Echinococcus granulosus histone lysine methyltransferase setb 0.0064 0.0595 0.0585
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0122 0.0113
Loa Loa (eye worm) hypothetical protein 0.0035 0.029 0.029
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0019 0.0118 0.0223
Schistosoma mansoni hypothetical protein 0.0027 0.0205 0.0195
Mycobacterium ulcerans pyruvate kinase 0.0035 0.0292 0.1038
Leishmania major DNA polymerase eta, putative 0.0019 0.0122 0.0222
Brugia malayi Pre-SET motif family protein 0.0064 0.0595 0.1086
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0122 0.0122
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0024 0.0176 0.1899
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0137 0.1353 0.5928
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0066 0.0617 0.5147
Mycobacterium tuberculosis Probable reductase 0.0123 0.121 0.5294
Plasmodium falciparum pyruvate kinase 0.0035 0.0292 0.2506
Trypanosoma cruzi trypanothione reductase, putative 0.0054 0.0486 0.3803
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.029 0.1031
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0069 0.0648 0.0638
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0225 0.2276 1
Entamoeba histolytica hypothetical protein 0.0109 0.1059 1
Loa Loa (eye worm) leukotriene A4 hydrolase 0.0024 0.0177 0.0177
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0064 0.0595 0.0585
Schistosoma mansoni transcription factor LCR-F1 0.0109 0.1059 0.105
Echinococcus granulosus GTP binding nuclear protein Ran 0.0066 0.0617 0.0607
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0036 0.0301 0.2094
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0039 0.0326 0.0317
Mycobacterium ulcerans aminopeptidase N PepN 0.0069 0.0648 0.2346
Trypanosoma brucei hypothetical protein 0.0111 0.1087 1
Schistosoma mansoni pyruvate kinase 0.0035 0.0292 0.0283
Trypanosoma cruzi target of rapamycin kinase 3 0.0039 0.0326 0.2151
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.053 0.5479 1
Onchocerca volvulus Pyruvate kinase homolog 0.0035 0.0292 0.0535
Schistosoma mansoni hypothetical protein 0.0407 0.4182 0.4176
Entamoeba histolytica hypothetical protein 0.0109 0.1059 1
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0301 0.1893
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0111 0.1087 1
Loa Loa (eye worm) inositol-1 0.0036 0.0301 0.0301
Schistosoma mansoni z-protein (S1r protein) 0.0009 0.0014 0.0004
Trypanosoma cruzi Aminopeptidase M1, putative 0.0069 0.0648 0.5467
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0069 0.0648 0.0638
Loa Loa (eye worm) hypothetical protein 0.0035 0.029 0.029
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0122 0.0606
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0039 0.0326 0.0317
Echinococcus granulosus segment polarity protein dishevelled 0.0009 0.0014 0.0004
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0098 0.0161
Trichomonas vaginalis importin beta-1, putative 0.0073 0.0687 0.1239
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0064 0.0595 0.0585
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0111 0.1087 1
Echinococcus multilocularis tar DNA binding protein 0.0062 0.057 0.0561
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0036 0.0301 0.3369
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0065 0.0608 0.0598
Loa Loa (eye worm) RNA binding protein 0.0062 0.057 0.057
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0122 0.0606
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0045 0.0393 0.0383
Schistosoma mansoni family M1 non-peptidase homologue (M01 family) 0.0045 0.0393 0.0383
Onchocerca volvulus Glucosylceramidase homolog 0.0348 0.3568 0.6831
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0111 0.1087 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0326 0.0578
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0039 0.0326 0.0595
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0021 0.0011
Loa Loa (eye worm) hypothetical protein 0.0019 0.0122 0.0122
Onchocerca volvulus 0.0029 0.0221 0.0398
Giardia lamblia NADH oxidase lateral transfer candidate 0.0019 0.0118 0.0109
Schistosoma mansoni ran 0.0066 0.0617 0.0607
Echinococcus granulosus Pleckstrin G protein interacting region 0.0009 0.0014 0.0004
Schistosoma mansoni regulator of G protein signaling 0.0009 0.0014 0.0004
Plasmodium falciparum thioredoxin reductase 0.0019 0.0118 0.0223
Toxoplasma gondii NADPH-glutathione reductase 0.0019 0.0118 0.1213
Trichomonas vaginalis PIKK family atypical protein kinase 0.0053 0.0477 0.0854
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0019 0.0118 0.0223
Echinococcus multilocularis geminin 0.0529 0.547 0.5465
Mycobacterium tuberculosis Conserved protein 0.0035 0.029 0.1237
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.002 0.0131 0.4147
Echinococcus granulosus thioredoxin glutathione reductase 0.0054 0.0486 0.0477
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0072 0.0114
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0066 0.0617 0.7074
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0052 0.0468 0.0458
Entamoeba histolytica hypothetical protein 0.0109 0.1059 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.015 0.0256
Entamoeba histolytica pyruvate kinase, putative 0.0025 0.018 0.0832
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0608 0.5052
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.029 0.1031
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0053 0.0477 0.0468
Trichomonas vaginalis glucosylceramidase, putative 0.0348 0.3568 0.6506
Plasmodium falciparum pyruvate kinase 2 0.0018 0.0112 0.0151
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0039 0.0326 0.0317
Brugia malayi Pyruvate kinase, M2 isozyme 0.0035 0.0292 0.0534
Loa Loa (eye worm) hypothetical protein 0.0158 0.158 0.158
Schistosoma mansoni dep domain containing protein 0.0009 0.0014 0.0004
Loa Loa (eye worm) TATA binding protein associated factor 0.0024 0.0177 0.0177
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0019 0.0118 0.0559
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0022 0.015 0.014
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0122 0.005
Brugia malayi tumor suppressor. 0.032 0.3271 0.5971
Schistosoma mansoni Tata binding protein associated factor (M01 family) 0.0024 0.0177 0.0167
Loa Loa (eye worm) pyruvate kinase-PB 0.0025 0.018 0.018
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.029 0.1782
Brugia malayi hypothetical protein 0.0069 0.0648 0.1182
Onchocerca volvulus Pyruvate kinase homolog 0.0035 0.0292 0.0535
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0123 0.121 0.5294
Schistosoma mansoni fyve finger-containing phosphoinositide kinase fyv1 0.0009 0.0014 0.0004
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0014 0.0066 0.012
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0024 0.0177 0.0306
Onchocerca volvulus 0.0069 0.0648 0.1218
Trichomonas vaginalis glucosylceramidase, putative 0.053 0.5479 1
Echinococcus multilocularis pyruvate kinase 0.0018 0.0112 0.0102
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0131 0.0131
Toxoplasma gondii aminopeptidase n, putative 0.0024 0.0177 0.1913
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0806 0.8367 0.8366
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0052 0.0468 0.0854
Leishmania major pyruvate kinase 0.0035 0.0292 0.1944
Brugia malayi F/Y-rich N-terminus family protein 0.0011 0.0038 0.0069
Onchocerca volvulus 0.0035 0.029 0.0531
Brugia malayi Inositol-1 0.0036 0.0301 0.055
Schistosoma mansoni aminopeptidase A (M01 family) 0.0024 0.0177 0.0167
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0122 0.0113
Schistosoma mansoni pyruvate kinase 0.0018 0.0112 0.0102
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0019 0.0118 0.3694
Schistosoma mansoni pyruvate kinase 0.0035 0.0292 0.0283
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0123 0.121 0.893
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.029 0.0281
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0326 0.0578
Plasmodium vivax importin-beta 2, putative 0.009 0.0866 1
Echinococcus multilocularis dnaJ subfamily B 0.0407 0.4182 0.4176
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0039 0.0326 0.0317
Echinococcus multilocularis aminopeptidase N 0.0069 0.0648 0.0638
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0111 0.1087 1
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0024 0.0177 0.0614
Trichomonas vaginalis glucosylceramidase, putative 0.0367 0.3764 0.6865
Loa Loa (eye worm) hypothetical protein 0.0064 0.0595 0.0595
Schistosoma mansoni importin-beta 2 0.0017 0.0101 0.0091
Loa Loa (eye worm) hypothetical protein 0.0035 0.029 0.029
Plasmodium vivax pyruvate kinase 2, putative 0.0018 0.0112 0.0151
Plasmodium vivax hypothetical protein, conserved 0.0035 0.029 0.2481
Loa Loa (eye worm) pyruvate kinase 0.0035 0.0292 0.0292
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0326 0.0578
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0326 0.0578
Loa Loa (eye worm) beta-lactamase 0.0035 0.029 0.029
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.029 0.0281
Echinococcus granulosus dna polymerase eta 0.0019 0.0122 0.0113
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0122 0.0113
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0019 0.0118 0.0475
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0122 0.0222
Echinococcus multilocularis dna polymerase eta 0.0019 0.0122 0.0113
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0326 0.0578
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0052 0.0468 0.0468
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0019 0.0118 0.0223
Plasmodium falciparum glutathione reductase 0.0019 0.0118 0.0223
Echinococcus granulosus translational activator gcn1 0.0017 0.0101 0.0091
Loa Loa (eye worm) thioredoxin reductase 0.0054 0.0486 0.0486
Mycobacterium ulcerans beta-lactamase 0.0035 0.029 0.1031
Schistosoma mansoni dishevelled 0.0009 0.0014 0.0004
Trypanosoma cruzi pyruvate kinase 2, putative 0.0035 0.0292 0.1802
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.029 0.1237
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0111 0.1087 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0122 0.005
Echinococcus multilocularis transportin 1 0.0017 0.0101 0.0091
Echinococcus multilocularis importin 5 0.0017 0.0101 0.0091
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0069 0.0648 0.0638
Trypanosoma brucei importin beta-1 subunit, putative 0.009 0.0866 0.7844
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0069 0.0648 0.5467
Brugia malayi hypothetical protein 0.0109 0.1059 0.1933
Loa Loa (eye worm) hypothetical protein 0.0179 0.1797 0.1797
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0122 0.0606
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.029 0.1237
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0176 0.0304
Trichomonas vaginalis glucosylceramidase, putative 0.0348 0.3568 0.6506
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0131 0.0136
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0131 0.0395
Entamoeba histolytica hypothetical protein 0.0053 0.0477 0.393
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0009 0.0014 0.0026
Echinococcus granulosus hypothetical protein 0.0027 0.0205 0.0195
Loa Loa (eye worm) hypothetical protein 0.0045 0.0393 0.0393
Schistosoma mansoni hypothetical protein 0.0529 0.547 0.5465
Brugia malayi beta-lactamase 0.0035 0.029 0.053
Brugia malayi RNA binding protein 0.0062 0.057 0.1041
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0052 0.0468 0.0458
Echinococcus multilocularis transcription factor Dp 1 0.0038 0.0319 0.0309
Giardia lamblia DINP protein human, muc B family 0.0019 0.0122 0.0205
Plasmodium falciparum M1-family alanyl aminopeptidase, putative 0.0024 0.0177 0.1001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0326 0.0578
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0039 0.0326 0.2151
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0962 1 1
Echinococcus multilocularis muscleblind protein 0.0158 0.158 0.1572
Mycobacterium leprae conserved hypothetical protein 0.0035 0.029 0.2087
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0131 0.0121
Brugia malayi TATA binding protein associated factor 0.0024 0.0177 0.0323
Trypanosoma brucei calpain-like protein, putative 0.0111 0.1087 1
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0009 0.0014 0.0014
Leishmania major importin beta-1 subunit, putative 0.0073 0.0687 0.5947
Echinococcus granulosus dna polymerase kappa 0.0019 0.0122 0.0113
Echinococcus multilocularis Peptidase M1, membrane alanine aminopeptidase, N terminal 0.0069 0.0648 0.0638
Brugia malayi beta-lactamase family protein 0.0035 0.029 0.053
Trypanosoma brucei pyruvate kinase 1, putative 0.0035 0.0292 0.226
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0011 0.0039 0.0029
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0326 0.0578
Trichomonas vaginalis pyruvate kinase, putative 0.0035 0.0292 0.0516
Toxoplasma gondii exonuclease III APE 0.002 0.0131 0.1368
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0326 0.0578
Onchocerca volvulus 0.0505 0.5217 1
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0069 0.0648 0.0638
Brugia malayi N-terminal motif family protein 0.0179 0.1797 0.328
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0326 0.0578
Loa Loa (eye worm) hypothetical protein 0.0024 0.0177 0.0177
Echinococcus granulosus geminin 0.0529 0.547 0.5465
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0122 0.0413
Trichomonas vaginalis glutaminase, putative 0.0268 0.2729 0.4971
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0111 0.1087 1
Schistosoma mansoni ran 0.0066 0.0617 0.0607
Schistosoma mansoni inositol monophosphatase 0.0036 0.0301 0.0291
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0053 0.0477 0.406
Loa Loa (eye worm) phosphatidylinositol 3 0.0039 0.0326 0.0326
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0123 0.121 0.5294
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0326 0.0578
Onchocerca volvulus 0.0064 0.0595 0.1116
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0022 0.015 0.0334
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.029 0.029
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0122 0.005
Schistosoma mansoni tar DNA-binding protein 0.0062 0.057 0.0561
Schistosoma mansoni cytosol alanyl aminopeptidase (M01 family) 0.0069 0.0648 0.0638
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0122 0.0496
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0069 0.0648 0.1166
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0122 0.0413
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0326 0.0578
Brugia malayi TAR-binding protein 0.0062 0.057 0.1041
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0053 0.0477 0.0871
Loa Loa (eye worm) glutaminase 2 0.0268 0.2729 0.2729
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0326 0.0578
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0039 0.0326 0.259
Leishmania major hypothetical protein, conserved 0.0035 0.029 0.1924
Trypanosoma brucei metallo-peptidase, Clan MA(E) Family M1 0.0069 0.0648 0.572
Loa Loa (eye worm) glutaminase 0.0268 0.2729 0.2729
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0069 0.0648 0.0638
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.029 0.1237
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0176 0.0304
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0109 0.1059 0.105
Trichomonas vaginalis set domain proteins, putative 0.0505 0.5217 0.952
Trichomonas vaginalis glucosylceramidase, putative 0.053 0.5479 1
Trypanosoma brucei importin beta-1 subunit, putative 0.009 0.0866 0.7844
Schistosoma mansoni hypothetical protein 0.0017 0.0098 0.0088
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0111 0.1087 1
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0064 0.0595 0.0585
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0039 0.0326 0.2287
Entamoeba histolytica aminopeptidase, putative 0.0069 0.0648 0.571
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0326 0.0578
Trichomonas vaginalis glucosylceramidase, putative 0.0367 0.3764 0.6865
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.002 0.0131 0.0444
Trichomonas vaginalis hypothetical protein 0.0017 0.0101 0.0165
Loa Loa (eye worm) hypothetical protein 0.0046 0.0399 0.0399
Echinococcus multilocularis pyruvate kinase 0.0035 0.0292 0.0283
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0066 0.0617 1
Leishmania major pyruvate kinase 0.0035 0.0292 0.1944
Echinococcus granulosus inositol monophosphatase 1 0.0036 0.0301 0.0291
Schistosoma mansoni hypothetical protein 0.0962 1 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0122 0.0606
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.029 0.0281
Loa Loa (eye worm) hypothetical protein 0.0027 0.0205 0.0205
Schistosoma mansoni tar DNA-binding protein 0.0062 0.057 0.0561
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0111 0.1087 1
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0131 0.0121
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.029 0.1782
Echinococcus granulosus muscleblind protein 0.0158 0.158 0.1572
Echinococcus multilocularis regulator of G protein signaling 7 0.0009 0.0014 0.0004
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0122 0.0606
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0052 0.0468 0.0458
Trichomonas vaginalis glucosylceramidase, putative 0.053 0.5479 1
Trypanosoma brucei unspecified product 0.0019 0.0122 0.0606
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0326 0.0578
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0301 0.1893
Loa Loa (eye worm) hypothetical protein 0.0009 0.0014 0.0014
Trichomonas vaginalis glucosylceramidase, putative 0.0348 0.3568 0.6506
Brugia malayi DIX domain containing protein 0.0009 0.0014 0.0026
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0019 0.0118 0.1213
Trypanosoma brucei Aminopeptidase M1, putative 0.0069 0.0648 0.572
Leishmania major puromycin-sensitive aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0024 0.0177 0.0777
Echinococcus granulosus serine protein kinase ATM 0.0053 0.0477 0.0468
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0122 0.0606
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0039 0.0326 0.259
Toxoplasma gondii target of rapamycin (TOR), putative 0.0039 0.0326 0.3663
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0054 0.0486 0.2103
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0131 0.0239

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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