TDR Targets

Basic information

Technical information

TDR Targets ID: 73756
Name: 3-methyl-10H-imidazo[4,5-a]carbazole
MW: 221.257 | Formula: C14H11N3
H donors: 1 H acceptors: 1 LogP: 2.9 Rotable bonds: 0
Rule of 5 violations (Lipinski): 1
SMILES: Cn1cnc2c1ccc1c2[nH]c2c1cccc2
InChi: 1S/C14H11N3/c1-17-8-15-14-12(17)7-6-10-9-4-2-3-5-11(9)16-13(10)14/h2-8,16H,1H3
InChiKey: IVCANFWWMQEZLF-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Mycobacterium leprae	conserved hypothetical protein	0.0035	0.0168	0.2019
Mycobacterium ulcerans	acyl-CoA synthetase	0.0023	0.0094	0.1106
Plasmodium falciparum	plasmepsin IX	0.0091	0.0514	0.5008
Mycobacterium ulcerans	hypothetical protein	0.0035	0.0168	0.2019
Brugia malayi	hypothetical protein	0.0011	0.0021	0.0148
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0016	0.0052	0.0356
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0035	0.0168	0.2019
Plasmodium falciparum	plasmepsin V	0.0091	0.0514	0.5008
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0098	0.0556	0.3954
Schistosoma mansoni	endothelin-converting enzyme-related	0.0023	0.0091	0.0164
Schistosoma mansoni	hypothetical protein	0.0024	0.0101	0.0182
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0009	0.0005	0.0008
Brugia malayi	Carboxylesterase family protein	0.0011	0.0021	0.0148
Schistosoma mansoni	neprilysin	0.0024	0.0101	0.0182
Echinococcus granulosus	geminin	0.0506	0.3085	0.4977
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0035	0.0168	0.1225
Schistosoma mansoni	BC026374 protein (S09 family)	0.0011	0.0021	0.0037
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0224	0.1336	1
Schistosoma mansoni	hypothetical protein	0.0031	0.0142	0.0256
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0094	0.0374
Plasmodium vivax	ataxin-2 like protein, putative	0.0025	0.0103	0.0493
Toxoplasma gondii	aspartyl protease ASP1	0.0164	0.0968	1
Schistosoma mansoni	ferritin	0.0009	0.0004	0.0008
Brugia malayi	peptidase family M13 containing protein	0.0023	0.0091	0.0649
Loa Loa (eye worm)	acetyltransferase	0.0141	0.0826	0.3292
Echinococcus granulosus	dnaJ subfamily B	0.0404	0.2452	0.3955
Echinococcus multilocularis	ceramide glucosyltransferase	0.0235	0.1407	0.1407
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0011	0.0021	0.0037
Echinococcus multilocularis	cathepsin d (lysosomal aspartyl protease)	0.0164	0.0968	0.0968
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0011	0.0021	0.0037
Echinococcus multilocularis	endothelin converting enzyme 1	0.0093	0.0528	0.0528
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0168	0.0668
Echinococcus multilocularis	acetylcholinesterase	0.0067	0.0365	0.0365
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0057	0.0305	0.2337
Onchocerca volvulus		0.0091	0.0514	0.3555
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0388	0.1545
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0091	0.0514	0.0924
Echinococcus granulosus	endothelin converting enzyme 1	0.0093	0.0528	0.0852
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0011	0.0021	0.0037
Schistosoma mansoni	ferritin	0.0009	0.0004	0.0008
Plasmodium falciparum	plasmepsin III	0.0091	0.0514	0.5008
Echinococcus granulosus	beta LACTamase domain containing family member	0.0035	0.0168	0.027
Echinococcus granulosus	expressed protein	0.0009	0.0004	0.0007
Schistosoma mansoni	gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2	0.0141	0.0826	0.1485
Schistosoma mansoni	memapsin-2 (A01 family)	0.0906	0.556	1
Brugia malayi	Hypothetical zinc metalloproteinase T16A9.4	0.0093	0.0528	0.3753
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.0168	0.0954
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0035	0.0168	0.0301
Schistosoma mansoni	hypothetical protein	0.0024	0.0101	0.0182
Loa Loa (eye worm)	hypothetical protein	0.0093	0.0528	0.2106
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0023	0.0094	0.1106
Echinococcus granulosus	lamin	0.0026	0.0114	0.0183
Brugia malayi	beta-lactamase	0.0035	0.0168	0.1191
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0168	0.0668
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0021	0.0083
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0037	0.0179	0.0179
Onchocerca volvulus		0.0023	0.0094	0.0527
Echinococcus granulosus	GPCR family 2	0.0031	0.0142	0.023
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0285	0.1715	1
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0023	0.0094	0.0671
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0091	0.0514	0.0924
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0142	0.0568
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0021	0.0083
Loa Loa (eye worm)	hypothetical protein	0.0413	0.2508	1
Echinococcus multilocularis	cytoplasmic intermediate filament protein	0.0013	0.0029	0.0029
Onchocerca volvulus		0.0026	0.0114	0.0669
Plasmodium vivax	aspartyl proteinase, putative	0.0164	0.0968	1
Brugia malayi	aspartic protease BmAsp-1, identical	0.0091	0.0514	0.365
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0058	0.023
Giardia lamblia	Fructose-bisphosphate aldolase	0.0285	0.1715	1
Brugia malayi	Tyrosyl-DNA phosphodiesterase family protein	0.0064	0.0349	0.2481
Schistosoma mansoni	ferritin light chain	0.0009	0.0004	0.0008
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0026	0.0114	0.0453
Mycobacterium ulcerans	fructose-bisphosphate aldolase	0.0139	0.0813	1
Loa Loa (eye worm)	transcription factor SMAD2	0.0117	0.0674	0.2685
Mycobacterium tuberculosis	Conserved protein	0.0035	0.0168	0.1225
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0388	0.1545
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0285	0.1715	1
Brugia malayi	hypothetical protein	0.0091	0.0514	0.365
Echinococcus granulosus	BC026374 protein S09 family	0.0011	0.0021	0.0034
Schistosoma mansoni	apoferritin-2	0.0009	0.0004	0.0008
Mycobacterium ulcerans	acyl-CoA synthetase	0.0023	0.0094	0.1106
Plasmodium falciparum	histone acetyltransferase GCN5	0.0038	0.0187	0.1416
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0029	0.0117
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0098	0.0556	0.2219
Loa Loa (eye worm)	aspartyl protease 6	0.0091	0.0514	0.2048
Brugia malayi	Carboxylesterase family protein	0.0067	0.0365	0.2595
Loa Loa (eye worm)	hypothetical protein	0.0069	0.0377	0.1505
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0388	0.1545
Brugia malayi	beta-lactamase family protein	0.0035	0.0168	0.1191
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0031	0.0142	0.023
Entamoeba histolytica	hypothetical protein	0.0037	0.0179	0.0524
Schistosoma mansoni	cpg binding protein	0.003	0.0136	0.0245
Echinococcus multilocularis	family S9 non peptidase ue (S09 family)	0.0011	0.0021	0.0021
Entamoeba histolytica	hypothetical protein	0.0037	0.0179	0.0524
Onchocerca volvulus		0.0028	0.0126	0.0761
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0035	0.0168	0.0668
Echinococcus multilocularis	neuroligin	0.0011	0.0021	0.0021
Schistosoma mansoni	hypothetical protein	0.0031	0.0142	0.0256
Schistosoma mansoni	Nep2 peptidase (M13 family)	0.0047	0.0242	0.0435
Loa Loa (eye worm)	hypothetical protein	0.0091	0.0514	0.2048
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.0017	0.0058	0.5
Mycobacterium ulcerans	carboxylesterase, LipT	0.0011	0.0021	0.0202
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0285	0.1715	1
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0098	0.0556	0.3954
Schistosoma mansoni	hypothetical protein	0.0037	0.0179	0.0322
Onchocerca volvulus		0.0035	0.0168	0.1059
Schistosoma mansoni	lamin	0.0026	0.0114	0.0204
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.0168	0.0954
Leishmania major	tyrosyl-DNA phosphodiesterase 1	0.0064	0.0349	1
Loa Loa (eye worm)	hypothetical protein	0.0093	0.0528	0.2106
Plasmodium vivax	plasmepsin IV, putative	0.0164	0.0968	1
Mycobacterium tuberculosis	Probable zinc metalloprotease Zmp1	0.0093	0.0528	0.3932
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0028	0.0126	0.0504
Plasmodium falciparum	plasmepsin X	0.0091	0.0514	0.5008
Schistosoma mansoni	transcription factor LCR-F1	0.0037	0.0179	0.0322
Brugia malayi	Pepsin A precursor	0.0091	0.0514	0.365
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0168	0.0668
Toxoplasma gondii	ABC1 family protein	0.0035	0.0168	0.0751
Brugia malayi	aspartic protease BmAsp-2, identical	0.0091	0.0514	0.365
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0091	0.0514	0.0924
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0285	0.1715	1
Schistosoma mansoni	hypothetical protein	0.0404	0.2452	0.441
Loa Loa (eye worm)	aspartic protease BmAsp-2	0.0164	0.0968	0.3861
Loa Loa (eye worm)	aspartic protease BmAsp-1	0.0091	0.0514	0.2048
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0285	0.1715	1
Echinococcus multilocularis	expressed protein	0.0009	0.0004	0.0004
Schistosoma mansoni	ferritin	0.0009	0.0004	0.0008
Schistosoma mansoni	ferritin light chain	0.0009	0.0004	0.0008
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0067	0.0365	0.0657
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0011	0.0021	0.0122
Loa Loa (eye worm)	carboxylesterase	0.0067	0.0365	0.1456
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0168	0.0668
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0035	0.0168	0.1225
Onchocerca volvulus		0.0035	0.0168	0.1059
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0164	0.0968	0.1742
Mycobacterium ulcerans	acyl-CoA synthetase	0.0023	0.0094	0.1106
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0031	0.0142	0.0568
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0026	0.0105
Schistosoma mansoni	family M13 unassigned peptidase (M13 family)	0.0023	0.0091	0.0164
Mycobacterium tuberculosis	Probable hydrolase	0.0035	0.0168	0.1225
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0021	0.0083
Plasmodium falciparum	plasmepsin II	0.0164	0.0968	1
Loa Loa (eye worm)	beta-lactamase	0.0035	0.0168	0.0668
Brugia malayi	acetyltransferase, GNAT family protein	0.0141	0.0826	0.5867
Echinococcus granulosus	Solute carrier family 22 5	0.101	0.6199	1
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0042	0.0208	0.0336
Mycobacterium tuberculosis	Probable esterase LipL	0.0035	0.0168	0.1225
Plasmodium vivax	plasmepsin V, putative	0.0091	0.0514	0.5008
Echinococcus granulosus	acetylcholinesterase	0.0067	0.0365	0.0589
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0365	0.1456
Mycobacterium leprae	Probable lipase LipE	0.0035	0.0168	0.2019
Trichomonas vaginalis	penicillin-binding protein, putative	0.0035	0.0168	0.0954
Trypanosoma brucei	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0064	0.0349	1
Schistosoma mansoni	hypothetical protein	0.0031	0.0142	0.0256
Schistosoma mansoni	apoferritin-2	0.0009	0.0004	0.0008
Schistosoma mansoni	hypothetical protein	0.0031	0.0142	0.0256
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0111	0.0441
Echinococcus granulosus	carboxylesterase 5A	0.0067	0.0365	0.0589
Echinococcus multilocularis	ferritin	0.0009	0.0004	0.0004
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0017	0.0058	0.0399
Mycobacterium tuberculosis	Conserved protein	0.0035	0.0168	0.1225
Schistosoma mansoni	lamin	0.0026	0.0114	0.0204
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0388	0.1545
Mycobacterium ulcerans	hypothetical protein	0.0023	0.0094	0.1106
Plasmodium vivax	aspartyl proteinase, putative	0.0091	0.0514	0.5008
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0285	0.1715	1
Echinococcus multilocularis	musashi	0.0026	0.0114	0.0114
Echinococcus multilocularis	carboxylesterase 5A	0.0067	0.0365	0.0365
Schistosoma mansoni	hypothetical protein	0.0024	0.0101	0.0182
Brugia malayi	hypothetical protein	0.0016	0.0049	0.0347
Echinococcus multilocularis	cpg binding protein	0.003	0.0136	0.0136
Trypanosoma brucei	hypothetical protein, conserved	0.0035	0.0168	0.2637
Plasmodium vivax	aspartyl protease, putative	0.0091	0.0514	0.5008
Loa Loa (eye worm)	zinc metallopeptidase 4	0.0023	0.0091	0.0364
Mycobacterium tuberculosis	Probable lipase LipD	0.0035	0.0168	0.1225
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0365	0.1455
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0011	0.0021	0.0122
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0035	0.0168	0.1191
Loa Loa (eye worm)	acetylcholinesterase 1	0.0067	0.0365	0.1456
Schistosoma mansoni	ceramide glucosyltransferase	0.0235	0.1407	0.2531
Brugia malayi	AMP-binding enzyme family protein	0.0023	0.0094	0.0667
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0016	0.0052	0.0356
Loa Loa (eye worm)	hypothetical protein	0.0413	0.2508	1
Plasmodium falciparum	plasmepsin VI	0.0164	0.0968	1
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0091	0.0514	0.0924
Trichomonas vaginalis	esterase, putative	0.0035	0.0168	0.0954
Echinococcus granulosus	family S9 non peptidase ue S09 family	0.0011	0.0021	0.0034
Brugia malayi	hypothetical protein	0.0025	0.0103	0.0729
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0103	0.0409
Brugia malayi	beta-lactamase family protein	0.0035	0.0168	0.1191
Echinococcus multilocularis	geminin	0.0506	0.3085	0.3085
Trichomonas vaginalis	carboxylesterase domain containing protein, putative	0.0011	0.0021	0.0095
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0091	0.0514	0.0924
Echinococcus granulosus	neuroligin	0.0011	0.0021	0.0034
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.0168	0.0954
Loa Loa (eye worm)	hypothetical protein	0.0069	0.0377	0.1505
Leishmania major	hypothetical protein, conserved	0.0025	0.0103	0.0341
Schistosoma mansoni	intermediate filament proteins	0.0026	0.0114	0.0204
Echinococcus granulosus	ferritin	0.0009	0.0004	0.0007
Echinococcus granulosus	ceramide glucosyltransferase	0.0235	0.1407	0.227
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0031	0.0142	0.023
Plasmodium vivax	histone acetyltransferase GCN5, putative	0.0042	0.0208	0.1651
Entamoeba histolytica	acetyltransferase, GNAT family	0.0038	0.0187	0.0572
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0064	0.0349	1
Schistosoma mansoni	cathepsin D (A01 family)	0.0352	0.2128	0.3828
Schistosoma mansoni	family M13 unassigned peptidase (M13 family)	0.0023	0.0091	0.0164
Trichomonas vaginalis	spcc417.12 protein, putative	0.0011	0.0021	0.0095
Trypanosoma cruzi	hypothetical protein, conserved	0.0035	0.0168	0.2637
Echinococcus granulosus	cpg binding protein	0.003	0.0136	0.022
Loa Loa (eye worm)	MH2 domain-containing protein	0.0117	0.0674	0.2685
Echinococcus granulosus	tyrosyl DNA phosphodiesterase 1	0.0064	0.0349	0.0563
Toxoplasma gondii	eukaryotic aspartyl protease superfamily protein	0.0091	0.0514	0.4749
Loa Loa (eye worm)	hypothetical protein	0.0098	0.0556	0.2219
Brugia malayi	hypothetical protein	0.0037	0.0179	0.127
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0016	0.0052	0.0356
Echinococcus multilocularis	Ataxin 2, N terminal,domain containing protein	0.0011	0.0019	0.0019
Entamoeba histolytica	hypothetical protein	0.0037	0.0179	0.0524
Echinococcus granulosus	transcription factor Dp 1	0.0037	0.0181	0.0293
Schistosoma mansoni	family M13 unassigned peptidase (M13 family)	0.0047	0.0242	0.0435
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0023	0.0094	0.1106
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0021	0.0083
Onchocerca volvulus	Ceramide glucosyltransferase homolog	0.0235	0.1407	1
Plasmodium vivax	aspartyl protease, putative	0.0091	0.0514	0.5008
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0035	0.0168	0.1225
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0016	0.0052	0.0356
Echinococcus granulosus	acetylcholinesterase	0.0067	0.0365	0.0589
Toxoplasma gondii	histone lysine acetyltransferase GCN5-A	0.0042	0.0208	0.1218
Schistosoma mansoni	hypothetical protein	0.0011	0.0019	0.0034
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0365	0.1456
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0285	0.1715	1
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0091	0.0514	0.0924
Mycobacterium leprae	probable zinc metalloprotease	0.0093	0.0528	0.6481
Toxoplasma gondii	aspartyl protease ASP3	0.0091	0.0514	0.4749
Toxoplasma gondii	aspartyl proteinase (eimepsin), putative	0.0164	0.0968	1
Loa Loa (eye worm)	peptidase family M13 containing protein	0.0069	0.0377	0.1505
Echinococcus multilocularis	GPCR, family 2	0.0031	0.0142	0.0142
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0094	0.0374
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0091	0.0514	0.0924
Brugia malayi	Carboxylesterase family protein	0.0011	0.0021	0.0148
Mycobacterium ulcerans	zinc metalloprotease	0.0093	0.0528	0.6481
Schistosoma mansoni	family M13 unassigned peptidase (M13 family)	0.0024	0.0101	0.0182
Schistosoma mansoni	hypothetical protein	0.0024	0.0101	0.0182
Schistosoma mansoni	hypothetical protein	0.0067	0.0365	0.0656
Echinococcus granulosus	Ataxin 2 N terminaldomain containing protein	0.0011	0.0019	0.003
Plasmodium falciparum	plasmepsin I	0.0164	0.0968	1
Schistosoma mansoni	cathepsin D (A01 family)	0.0352	0.2128	0.3828
Mycobacterium tuberculosis	Probable fructose-bisphosphate aldolase Fba	0.0139	0.0813	0.6068
Plasmodium falciparum	plasmepsin VII	0.0091	0.0514	0.5008
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.006	0.0323	0.0581
Schistosoma mansoni	cpg binding protein	0.0028	0.0126	0.0227
Entamoeba histolytica	hypothetical protein	0.0037	0.0179	0.0524
Echinococcus granulosus	cytoplasmic intermediate filament protein	0.0013	0.0029	0.0047
Brugia malayi	Intermediate filament tail domain containing protein	0.0026	0.0114	0.0807
Loa Loa (eye worm)	peptidase family M13 containing protein	0.0069	0.0377	0.1505
Mycobacterium leprae	Probable fructose bisphosphate aldolase Fba	0.0139	0.0813	1
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0023	0.0094	0.1106
Loa Loa (eye worm)	hypothetical protein	0.0069	0.0377	0.1505
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0014	0.0038	0.0151
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0021	0.0083
Mycobacterium tuberculosis	Probable lipase LipE	0.0035	0.0168	0.1225
Loa Loa (eye worm)	hypothetical protein	0.0091	0.0514	0.2048
Trichomonas vaginalis	Clan AA, family A1, cathepsin D-like aspartic peptidase	0.0164	0.0968	0.5635
Plasmodium vivax	aspartyl protease, putative	0.0091	0.0514	0.5008
Brugia malayi	AMP-binding enzyme family protein	0.0023	0.0094	0.0667
Schistosoma mansoni	endothelin-converting enzyme-like 1 (damage-induced neuronal endopeptidase)	0.0023	0.0091	0.0164
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0023	0.0094	0.1106
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0031	0.0142	0.1012
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0031	0.0142	0.0142
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0031	0.0142	0.0142
Schistosoma mansoni	ferritin	0.0009	0.0004	0.0008
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0023	0.0094	0.1106
Trichomonas vaginalis	cat eye syndrome critical region protein 2, cscr2, putative	0.0042	0.0208	0.119
Leishmania major	hypothetical protein, conserved	0.0035	0.0168	0.2888
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0168	0.0668
Schistosoma mansoni	family M13 non-peptidase homologue (M13 family)	0.0023	0.0091	0.0164
Schistosoma mansoni	cpg binding protein	0.003	0.0136	0.0245
Mycobacterium ulcerans	lipase LipD	0.0035	0.0168	0.2019
Toxoplasma gondii	histone lysine acetyltransferase GCN5-B	0.0042	0.0208	0.1218
Echinococcus granulosus	lamin dm0	0.0026	0.0114	0.0183
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0026	0.0105
Onchocerca volvulus		0.0091	0.0514	0.3555
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0035	0.0168	0.0168
Echinococcus multilocularis	transcription factor Dp 1	0.0037	0.0181	0.0181
Toxoplasma gondii	aspartyl protease	0.0091	0.0514	0.4749
Brugia malayi	intermediate filament protein	0.0026	0.0114	0.0807
Schistosoma mansoni	gliotactin	0.0011	0.0021	0.0037
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0114	0.0453
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0388	0.1545
Brugia malayi	cytoplasmic intermediate filament protein	0.0014	0.0038	0.027
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0058	0.023
Brugia malayi	latrophilin 2 splice variant baaae	0.0067	0.0365	0.2592
Echinococcus multilocularis	lamin dm0	0.0026	0.0114	0.0114
Mycobacterium ulcerans	esterase/lipase LipP	0.0035	0.0168	0.2019
Onchocerca volvulus		0.0046	0.0237	0.1558
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0285	0.1715	1
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0091	0.0514	0.0924
Loa Loa (eye worm)	hypothetical protein	0.0093	0.0528	0.2106
Loa Loa (eye worm)	tyrosyl-DNA phosphodiesterase	0.0064	0.0349	0.1392
Schistosoma mansoni	neprilysin-2 (M13 family)	0.0047	0.0242	0.0435
Toxoplasma gondii	peptidase family M13 protein	0.0093	0.0528	0.4916
Loa Loa (eye worm)	ceramide glucosyltransferase	0.0235	0.1407	0.5611
Schistosoma mansoni	hypothetical protein	0.0024	0.0101	0.0182
Brugia malayi	CXXC zinc finger family protein	0.0028	0.0126	0.0898
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0023	0.0094	0.0671
Brugia malayi	Ceramide glucosyltransferase	0.0235	0.1407	1
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0023	0.0094	0.1106
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0058	0.023
Loa Loa (eye worm)	hypothetical protein	0.0164	0.0968	0.3861
Echinococcus multilocularis	lamin	0.0026	0.0114	0.0114
Entamoeba histolytica	tyrosyl-DNA phosphodiesterase, putative	0.0064	0.0349	0.1575
Schistosoma mansoni	ceramide glucosyltransferase	0.0235	0.1407	0.2531
Echinococcus multilocularis	gcn5proteinral control of amino acid synthesis	0.0141	0.0826	0.0826
Plasmodium falciparum	ataxin-2 like protein, putative	0.0025	0.0103	0.0493
Schistosoma mansoni	family M13 non-peptidase homologue (M13 family)	0.0047	0.0242	0.0435
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0137	0.0801	0.1292
Wolbachia endosymbiont of Brugia malayi	bacterioferritin/cytochrome b1	0.0009	0.0004	0.5
Schistosoma mansoni	tyrosyl-DNA phosphodiesterase	0.0064	0.0349	0.0628
Plasmodium falciparum	plasmepsin VIII, putative	0.0091	0.0514	0.5008
Loa Loa (eye worm)	histone methyltransferase	0.0009	0.0005	0.002
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0042	0.0208	0.119
Trypanosoma cruzi	hypothetical protein, conserved	0.0035	0.0168	0.2637
Brugia malayi	Peptidase family M13 containing protein	0.0093	0.0528	0.3753
Echinococcus multilocularis	BC026374 protein (S09 family)	0.0011	0.0021	0.0021
Loa Loa (eye worm)	carboxylesterase	0.0011	0.0021	0.0083
Mycobacterium tuberculosis	Conserved protein	0.0035	0.0168	0.1225
Trichomonas vaginalis	penicillin-binding protein, putative	0.0035	0.0168	0.0954
Plasmodium falciparum	ataxin-2 like protein, putative	0.0025	0.0103	0.0493
Brugia malayi	Latrophilin receptor protein 2	0.0031	0.0142	0.1012
Onchocerca volvulus		0.0026	0.0114	0.0669
Echinococcus multilocularis	tyrosyl DNA phosphodiesterase 1	0.0064	0.0349	0.0349
Brugia malayi	Carboxylesterase family protein	0.0011	0.0021	0.0148
Schistosoma mansoni	hypothetical protein	0.0506	0.3085	0.555
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0009	0.0005	0.0005
Brugia malayi	AMP-binding enzyme family protein	0.0023	0.0094	0.0667
Mycobacterium ulcerans	beta-lactamase	0.0035	0.0168	0.2019
Schistosoma mansoni	hypothetical protein	0.0506	0.3085	0.555
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0168	0.0668
Brugia malayi	Carboxylesterase family protein	0.0067	0.0365	0.2595
Echinococcus multilocularis	acetylcholinesterase	0.0067	0.0365	0.0365
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0021	0.0083
Schistosoma mansoni	acetylcholinesterase	0.0011	0.0021	0.0037
Echinococcus multilocularis	dnaJ subfamily B	0.0404	0.2452	0.2452
Brugia malayi	MH2 domain containing protein	0.0117	0.0674	0.4786
Loa Loa (eye worm)	carboxylesterase	0.0011	0.0021	0.0083
Loa Loa (eye worm)	hypothetical protein	0.0069	0.0377	0.1505
Schistosoma mansoni	neuroligin 3 (S09 family)	0.0011	0.0021	0.0037
Schistosoma mansoni	family M13 unassigned peptidase (M13 family)	0.0047	0.0242	0.0435
Schistosoma mansoni	hypothetical protein	0.0024	0.0101	0.0182
Echinococcus granulosus	cathepsin d lysosomal aspartyl protease	0.0164	0.0968	0.1562
Schistosoma mansoni	family M13 unassigned peptidase (M13 family)	0.0093	0.0528	0.095
Plasmodium vivax	hypothetical protein, conserved	0.0035	0.0168	0.1207
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0285	0.1715	1
Brugia malayi	hypothetical protein	0.0091	0.0514	0.365
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0388	0.1545
Schistosoma mansoni	family M13 unassigned peptidase (M13 family)	0.0023	0.0091	0.0164
Onchocerca volvulus		0.0035	0.0168	0.1059
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0285	0.1715	1
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0037	0.0179	0.0288
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0064	0.0349	1
Brugia malayi	F/Y-rich N-terminus family protein	0.0009	0.0004	0.0031
Echinococcus granulosus	intermediate filament protein	0.0026	0.0114	0.0183
Brugia malayi	Carboxylesterase family protein	0.0011	0.0021	0.0148
Giardia lamblia	Ceramide glucosyltransferase	0.0107	0.0611	0.2777
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0094	0.0374
Brugia malayi	Eukaryotic aspartyl protease family protein	0.0091	0.0514	0.365
Treponema pallidum	fructose-bisphosphate aldolase	0.0285	0.1715	1
Mycobacterium tuberculosis	Carboxylesterase LipT	0.0011	0.0021	0.0122
Plasmodium falciparum	plasmepsin IV	0.0164	0.0968	1
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0058	0.023
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0017	0.0058	0.0658
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0035	0.0168	0.0301
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0237	0.0944
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0021	0.0083
Echinococcus multilocularis	para nitrobenzyl esterase	0.0011	0.0021	0.0021
Loa Loa (eye worm)	intermediate filament protein	0.0026	0.0114	0.0453
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0058	0.023
Echinococcus granulosus	para nitrobenzyl esterase	0.0011	0.0021	0.0034

Activities

Activity type	Activity value	Assay description	Source	Reference
Activity (functional)	= 4 %	Glutathione peroxidase-like activity in relation to Ebselen glutathione peroxidase-like activity	ChEMBL.	10794693
Activity (functional)	= 20 uM	Glutathione peroxidase-like activity at 10x(E -2) M concentration as NADP+/L/min	ChEMBL.	10794693
Activity (functional)	= 29 uM	Glutathione peroxidase-like activity at 10x(E -4) M concentration measured as NADP+/L/min	ChEMBL.	10794693
Activity (functional)	= 29 uM	Glutathione peroxidase-like activity at 10x(E -4) M concentration measured as NADP+/L/min	ChEMBL.	10794693
Activity (functional)	= 42 uM	Glutathione peroxidase-like activity at 10x(E -3) M concentration as NADP+/L/min	ChEMBL.	10794693
Effective molarity (functional)	= 0.00001 M l-1	Antioxidative property against stable murine-murine hybridoma (Mark 3) cell line	ChEMBL.	10794693
Effective molarity (functional)	= 0.00001 M l-1	Antioxidative property against stable murine-murine hybridoma (Mark 3) cell line	ChEMBL.	10794693

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL52221
PubChem: 10609004

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 73756