Detailed information for compound 738667

Basic information

Technical information
  • TDR Targets ID: 738667
  • Name: 2-[[5-(2-chlorophenyl)-4-phenyl-1,2,4-triazol -3-yl]sulfanyl]-1-(2,3-dihydroindol-1-yl)etha none
  • MW: 446.952 | Formula: C24H19ClN4OS
  • H donors: 0 H acceptors: 3 LogP: 5.34 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(N1CCc2c1cccc2)CSc1nnc(n1c1ccccc1)c1ccccc1Cl
  • InChi: 1S/C24H19ClN4OS/c25-20-12-6-5-11-19(20)23-26-27-24(29(23)18-9-2-1-3-10-18)31-16-22(30)28-15-14-17-8-4-7-13-21(17)28/h1-13H,14-16H2
  • InChiKey: GGWXJWIIHIPMSP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[[5-(2-chlorophenyl)-4-phenyl-1,2,4-triazol-3-yl]sulfanyl]-1-indolin-1-yl-ethanone
  • 2-[[5-(2-chlorophenyl)-4-phenyl-1,2,4-triazol-3-yl]thio]-1-(1-indolinyl)ethanone
  • 2-[[5-(2-chlorophenyl)-4-phenyl-1,2,4-triazol-3-yl]thio]-1-indolin-1-yl-ethanone
  • CBKinase1_009664
  • STK233026
  • CBKinase1_022064

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium vivax hypothetical protein, conserved 0.0013 0.0073 0.0314
Toxoplasma gondii heat shock protein 90, putative 0.0065 0.0833 0.5115
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0027 0.0053
Chlamydia trachomatis DNA gyrase subunit B 0.0013 0.0073 1
Trichomonas vaginalis receptor histidine kinase, putative 0.0013 0.0073 0.0209
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0027 0.0053
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0027 0.0027
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0027 0.0053
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0407 0.0407
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0162 0.1918
Echinococcus multilocularis lipoxygenase domain containing protein 0.0023 0.0216 0.0216
Echinococcus multilocularis phosphoserine phosphatase 0.0008 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0013 0.0073 0.0153
Trypanosoma brucei heat shock protein 90, putative 0.0065 0.0833 1
Onchocerca volvulus 0.0027 0.0275 0.0808
Trichomonas vaginalis protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative 0.016 0.2236 0.6646
Onchocerca volvulus 0.0027 0.0275 0.0808
Schistosoma mansoni voltage-gated potassium channel 0.0083 0.1098 0.1098
Entamoeba histolytica hypothetical protein 0.0036 0.0407 0.1808
Schistosoma mansoni lamin 0.0027 0.0275 0.0275
Toxoplasma gondii Hsp90 domain-containing protein 0.0027 0.027 0.1645
Echinococcus multilocularis dnaJ subfamily B 0.0408 0.5878 0.5878
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.049 0.5872
Echinococcus multilocularis protein farnesyltransferase alpha subunit 0.016 0.2236 0.2236
Trypanosoma cruzi heat shock protein 85, putative 0.0065 0.0833 1
Echinococcus multilocularis caspase 2 0.0053 0.0658 0.0658
Loa Loa (eye worm) hypothetical protein 0.0012 0.0063 0.013
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0026 0.0026
Schistosoma mansoni cation-transporting atpase worm 0.0008 0.0003 0.0003
Giardia lamblia Heat shock protein HSP 90-alpha 0.0065 0.0833 0.3715
Trichomonas vaginalis set domain proteins, putative 0.0237 0.3362 1
Mycobacterium tuberculosis Possible two component sensor kinase TcrY 0.0013 0.0073 0.1105
Echinococcus multilocularis RUN 0.0023 0.0216 0.0216
Leishmania major developmentally regulated phosphoprotein-like protein 0.0013 0.0073 0.0846
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0.0111 0.1299
Leishmania major heat shock protein 83-1 0.0065 0.0833 1
Trypanosoma brucei hypothetical protein, conserved 0.0042 0.049 0.5872
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0074 0.0859
Brugia malayi DNA gyrase/topoisomerase IV, A subunit family protein 0.0013 0.0073 0.0153
Schistosoma mansoni DNA topoisomerase II 0.0013 0.0073 0.0073
Trichomonas vaginalis sensor histidine kinase, putative 0.0013 0.0073 0.0209
Echinococcus granulosus RUN 0.0023 0.0216 0.0216
Brugia malayi Temporarily assigned gene name protein 44 0.0027 0.0278 0.0599
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0027 0.0027
Entamoeba histolytica heat shock protein 90, putative 0.0065 0.0833 0.3715
Trypanosoma cruzi DNA polymerase eta, putative 0.0045 0.0536 0.6422
Giardia lamblia Rab geranylgeranyltransferase 0.0042 0.049 0.2181
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0162 0.1918
Echinococcus granulosus tumor protein p63 0.0337 0.4835 0.4835
Schistosoma mansoni hypothetical protein 0.0023 0.0216 0.0216
Brugia malayi steroid hormone receptor 0.001 0.0027 0.0053
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.001 0.0028 0.0301
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0033 0.0369 0.0797
Plasmodium vivax heat shock protein 86, putative 0.0065 0.0833 0.3715
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0027 0.0053
Mycobacterium ulcerans two component system membrane associated sensor kinase 0.0013 0.0073 0.1105
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0027 0.0053
Trypanosoma cruzi heat shock protein 90, putative 0.0052 0.0638 0.7659
Echinococcus granulosus hypothetical protein 0.0027 0.0278 0.0278
Schistosoma mansoni Na+/K+ transporting ATPase subunit alpha 0.0008 0.0003 0.0003
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0053 0.0658 0.1425
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0162 0.1918
Brugia malayi Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit 0.0083 0.1098 0.2384
Trypanosoma brucei heat shock protein, putative 0.0065 0.0833 1
Echinococcus granulosus dna polymerase eta 0.0045 0.0536 0.0536
Loa Loa (eye worm) hypothetical protein 0.0026 0.0268 0.0576
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0074 0.0859
Leishmania major metacaspase, putative 0.0053 0.0658 0.7892
Leishmania major heat shock protein 83-1 0.0065 0.0833 1
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.0658 0.1949
Onchocerca volvulus Putative DNA topoisomerase 2, mitochondrial 0.0013 0.0073 0.0209
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0027 0.0027
Echinococcus multilocularis endoplasmin 0.0052 0.0638 0.0638
Leishmania major heat shock protein 83-1 0.0065 0.0833 1
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0013 0.0073 0.0846
Loa Loa (eye worm) hypothetical protein 0.001 0.0027 0.0053
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0027 0.0053
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0052 0.0638 0.7659
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0027 0.0053
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0013 0.0073 0.0209
Echinococcus multilocularis calcium transporting ATPase type 2C member 0.0008 0.0003 0.0003
Leishmania major mitochondrial DNA topoisomerase II 0.0013 0.0073 0.0846
Treponema pallidum DNA gyrase, subunit B (gyrB) 0.0013 0.0073 0.1105
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0033 0.0358 0.1587
Trypanosoma cruzi developmentally regulated phosphoprotein, putative 0.0013 0.0073 0.0846
Leishmania major DNA polymerase eta, putative 0.0031 0.0341 0.4069
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0053 0.0658 0.1949
Echinococcus granulosus heat shock protein 90 0.0065 0.0833 0.0833
Leishmania major DNA topoisomerase ii 0.0013 0.0073 0.0846
Leishmania major DNA polymerase kappa, putative 0.0019 0.0162 0.1918
Trypanosoma brucei unspecified product 0.0013 0.0074 0.0859
Echinococcus granulosus endoplasmin 0.0052 0.0638 0.0638
Echinococcus multilocularis caspase 0.0198 0.2791 0.2791
Schistosoma mansoni DNA polymerase eta 0.0045 0.0536 0.0536
Echinococcus multilocularis DNA topoisomerase 2 alpha 0.0013 0.0073 0.0073
Trichomonas vaginalis rotamase, putative 0.0033 0.0369 0.1089
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0162 0.2504
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0031 0.0341 0.2081
Leishmania major protein farnesyltransferase alpha subunit, putative 0.0042 0.049 0.5872
Echinococcus granulosus phospholipid transporting ATPase VA 0.0008 0.0003 0.0003
Plasmodium vivax endoplasmin, putative 0.0065 0.0833 0.3715
Echinococcus granulosus heat shock protein 90 0.0052 0.0638 0.0638
Leishmania major heat shock protein 83-1 0.0065 0.0833 1
Mycobacterium tuberculosis Two component sensory transduction histidine kinase MtrB 0.0013 0.0073 0.1105
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0027 0.0027
Entamoeba histolytica Rab geranylgeranyltransferase alpha subunit, putative 0.0042 0.049 0.2181
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0027 0.0053
Brugia malayi kinase, mitochondrial precursor 0.0013 0.0073 0.0153
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0016 0.0111 0.0483
Echinococcus multilocularis phosphoserine phosphatase 0.0008 0.0003 0.0003
Onchocerca volvulus 0.0023 0.0216 0.0634
Schistosoma mansoni survival motor neuron protein 0.0048 0.0587 0.0587
Brugia malayi ImpB/MucB/SamB family protein 0.0045 0.0536 0.116
Mycobacterium ulcerans two component system response phosphate sensor kinase, PhoR 0.0013 0.0073 0.1105
Trypanosoma cruzi DNA topoisomerase II, putative 0.0013 0.0073 0.0846
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0198 0.2791 0.2791
Brugia malayi nuclear receptor NHR-88 0.001 0.0027 0.0053
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0016 0.0111 0.1696
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0111 0.1299
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.0658 0.1949
Loa Loa (eye worm) histone methyltransferase 0.001 0.0026 0.0049
Trypanosoma brucei DNA polymerase eta, putative 0.0045 0.0536 0.6422
Echinococcus granulosus caspase 8 0.0053 0.0658 0.0658
Mycobacterium ulcerans two component sensory transduction histidine kinase MtrB 0.0013 0.0073 0.1105
Loa Loa (eye worm) hypothetical protein 0.0088 0.1172 0.2544
Echinococcus granulosus plasma membrane calcium transporting ATPase 2 0.0008 0.0003 0.0003
Trichomonas vaginalis heat shock protein, putative 0.004 0.0464 0.1372
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0052 0.0638 1
Brugia malayi Protein prenyltransferase alpha subunit repeat containing protein 0.0042 0.049 0.106
Echinococcus multilocularis phospholipid transporting ATPase IIB 0.0008 0.0003 0.0003
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.0013 0.007 0.0146
Leishmania major heat shock protein 83-1 0.0065 0.0833 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0326 0.0326
Trypanosoma cruzi metacaspase, putative 0.0053 0.0658 0.7892
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0027 0.0027
Echinococcus multilocularis sarco:endoplasmic reticulum calcium ATPase 0.0008 0.0003 0.0003
Trypanosoma brucei Protein prenyltransferase alpha subunit repeat, putative 0.0042 0.049 0.5872
Toxoplasma gondii peptidylprolyl isomerase 0.0033 0.0358 0.2185
Brugia malayi Pre-SET motif family protein 0.003 0.0326 0.0703
Echinococcus granulosus DNA topoisomerase 2 alpha 0.0013 0.0073 0.0073
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0053 0.0658 0.1949
Wolbachia endosymbiont of Brugia malayi membrane associated signal transduction histidine kinase 0.0013 0.0073 0.0741
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0162 0.1918
Echinococcus granulosus cation transporting ATPase 13A1 0.0008 0.0003 0.0003
Brugia malayi ecdysteroid receptor 0.001 0.0027 0.0053
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.0027 0.027 0.0794
Leishmania major heat shock protein 83-1 0.0065 0.0833 1
Brugia malayi hypothetical protein 0.0023 0.0216 0.0464
Onchocerca volvulus 0.0042 0.049 0.145
Mycobacterium leprae Probable two component sensor kinase MprB 0.0013 0.0073 0.1105
Schistosoma mansoni heat shock protein 0.0027 0.027 0.027
Trichomonas vaginalis protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative 0.0119 0.1625 0.4827
Leishmania major heat shock protein 83-1 0.0065 0.0833 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0027 0.0053
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0162 0.0713
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0027 0.0027
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0275 0.0591
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.0658 0.1949
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0013 0.0073 0.0209
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0052 0.0638 1
Mycobacterium ulcerans heat shock protein 90 0.0052 0.0638 1
Mycobacterium tuberculosis Possible two component sensor kinase 0.0013 0.0073 0.1105
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.016 0.2236 0.6646
Echinococcus granulosus cation transporting atpase worm 0.0008 0.0003 0.0003
Giardia lamblia DINP protein human, muc B family 0.0019 0.0162 0.0713
Schistosoma mansoni phosphoserine phosphatase 0.0008 0.0003 0.0003
Schistosoma mansoni cellular tumor antigen P53 0.0049 0.0605 0.0605
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0027 0.0053
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0162 0.0346
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0301 0.0301
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0053 0.0658 0.0658
Loa Loa (eye worm) hypothetical protein 0.0013 0.0073 0.0153
Echinococcus granulosus geranylgeranyl transferase type 2 subunit alpha 0.0042 0.049 0.049
Echinococcus granulosus expressed protein 0.0033 0.0369 0.0369
Echinococcus multilocularis Polycystic kidney disease protein 0.0023 0.0216 0.0216
Trypanosoma cruzi protein farnesyltransferase alpha subunit, putative 0.0042 0.049 0.5872
Mycobacterium tuberculosis Conserved protein 0.0013 0.0073 0.1105
Schistosoma mansoni hypothetical protein 0.0027 0.0278 0.0278
Echinococcus granulosus copper transporting ATPase 1 0.0008 0.0003 0.0003
Brugia malayi hypothetical protein 0.0023 0.0216 0.0464
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0091 0.0191
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0111 0.0111
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0162 0.1918
Mycobacterium ulcerans two component sensor histidine kinase TrcS 0.0013 0.0073 0.1105
Leishmania major heat shock protein 83-1 0.0065 0.0833 1
Mycobacterium tuberculosis Two component sensor histidine kinase DosT 0.0013 0.0073 0.1105
Trypanosoma brucei DNA topoisomerase ii 0.0013 0.0073 0.0846
Loa Loa (eye worm) hypothetical protein 0.0053 0.0658 0.1425
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0013 0.0073 0.0433
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0162 0.1918
Echinococcus multilocularis protein prenyltransferase alpha subunit 0.0042 0.049 0.049
Leishmania major heat shock protein 83-1 0.0065 0.0833 1
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.016 0.2236 0.6646
Echinococcus multilocularis cation transporting ATPase 13A1 0.0008 0.0003 0.0003
Treponema pallidum heat shock protein 90 0.0052 0.0638 1
Trypanosoma cruzi heat shock protein, putative 0.0027 0.027 0.3215
Loa Loa (eye worm) hypothetical protein 0.001 0.0027 0.0053
Onchocerca volvulus Cell death protein 3 homolog 0.0053 0.0658 0.1949
Mycobacterium tuberculosis Two component sensor histidine kinase PrrB 0.0013 0.0073 0.1105
Schistosoma mansoni intermediate filament proteins 0.0027 0.0275 0.0275
Trypanosoma cruzi Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0013 0.0073 0.0846
Echinococcus granulosus caspase 2 0.0053 0.0658 0.0658
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.0013 0.0073 0.1105
Echinococcus granulosus potassium voltage gated channel protein 0.0083 0.1098 0.1098
Schistosoma mansoni protein farnesyltransferase alpha subunit 0.016 0.2236 0.2236
Trypanosoma brucei heat shock protein, putative 0.0065 0.0833 1
Leishmania major heat shock protein 83-1 0.0065 0.0833 1
Echinococcus multilocularis caspase 3 0.0145 0.2012 0.2012
Brugia malayi F/Y-rich N-terminus family protein 0.001 0.0024 0.0045
Entamoeba histolytica hypothetical protein 0.0036 0.0407 0.1808
Plasmodium vivax metacaspase 1, putative 0.0053 0.0658 0.2932
Trypanosoma brucei metacaspase 5, putative 0.0053 0.0658 0.7892
Schistosoma mansoni endoplasmin 0.0065 0.0833 0.0833
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.007 0.007
Echinococcus multilocularis musashi 0.0027 0.0275 0.0275
Schistosoma mansoni rotamase 0.0033 0.0369 0.0369
Loa Loa (eye worm) hypothetical protein 0.0027 0.0278 0.0599
Echinococcus granulosus lamin 0.0027 0.0275 0.0275
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0091 0.0191
Mycobacterium ulcerans sensor kinase from two component regulatory system 0.0013 0.0073 0.1105
Loa Loa (eye worm) hypothetical protein 0.0023 0.0216 0.0464
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0013 0.0073 0.0846
Echinococcus multilocularis potassium voltage gated channel protein 0.0083 0.1098 0.1098
Schistosoma mansoni cpg binding protein 0.003 0.0324 0.0324
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0027 0.0053
Brugia malayi nuclear hormone receptor 0.001 0.0027 0.0053
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.0027 0.027 0.027
Echinococcus granulosus dna polymerase kappa 0.0019 0.0162 0.0162
Loa Loa (eye worm) hypothetical protein 0.001 0.0027 0.0053
Schistosoma mansoni cpg binding protein 0.003 0.0324 0.0324
Loa Loa (eye worm) TOPoisomerase family member 0.0013 0.0073 0.0153
Plasmodium falciparum DNA topoisomerase 2 0.0013 0.0073 0.0314
Echinococcus multilocularis phosphoserine phosphatase 0.0008 0.0003 0.0003
Mycobacterium tuberculosis Possible two component system response sensor kinase membrane associated PhoR 0.0013 0.0073 0.1105
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0326 0.0326
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0162 0.0474
Trichomonas vaginalis DNA topoisomerase II, putative 0.0013 0.0073 0.0209
Mycobacterium ulcerans DNA gyrase subunit B 0.0013 0.0073 0.1105
Trypanosoma cruzi heat shock protein 85, putative 0.0052 0.0638 0.7659
Echinococcus granulosus Polycystic kidney disease protein 0.0023 0.0216 0.0216
Plasmodium vivax protein prenyltransferase alpha subunit, putative 0.0042 0.049 0.2181
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0033 0.0369 0.0797
Toxoplasma gondii DNA topoisomerase 2, putative 0.0013 0.0073 0.0433
Trypanosoma cruzi DNA topoisomerase II, putative 0.0013 0.0073 0.0846
Loa Loa (eye worm) hypothetical protein 0.0045 0.0536 0.116
Leishmania major heat shock protein 83-1 0.0065 0.0833 1
Echinococcus granulosus FTZ F1 alpha 0.001 0.0027 0.0027
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.0658 0.1949
Loa Loa (eye worm) hypothetical protein 0.003 0.0326 0.0703
Plasmodium falciparum protein farnesyltransferase subunit alpha 0.016 0.2236 1
Leishmania major heat shock protein, putative 0.0027 0.027 0.3215
Trypanosoma cruzi DNA polymerase eta, putative 0.0031 0.0341 0.4069
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0053 0.0658 0.1949
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0027 0.0053
Mycobacterium tuberculosis Two component sensor kinase MprB 0.0013 0.0073 0.1105
Leishmania major heat shock protein 83-1 0.0065 0.0833 1
Mycobacterium tuberculosis Two component sensor histidine kinase DevS 0.0013 0.0073 0.1105
Schistosoma mansoni cpg binding protein 0.0029 0.03 0.03
Echinococcus multilocularis caspase 8 0.0053 0.0658 0.0658
Loa Loa (eye worm) hypothetical protein 0.0083 0.1098 0.2384
Trichomonas vaginalis two component sensor and regulator histidine kinase bacteria, putative 0.0013 0.0073 0.0209
Schistosoma mansoni eyes absent homolog 0.0088 0.1172 0.1172
Schistosoma mansoni loxhd1 0.0023 0.0216 0.0216
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0027 0.0027
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.0658 0.1949
Trichomonas vaginalis receptor histidine kinase, putative 0.0013 0.0073 0.0209
Plasmodium falciparum DNA gyrase subunit B 0.0013 0.0073 0.0314
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0326 0.1992
Trypanosoma cruzi heat shock protein 85, putative 0.0065 0.0833 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0162 0.1918
Trypanosoma brucei protein farnesyltransferase alpha subunit, putative 0.0042 0.049 0.5872
Schistosoma mansoni lamin 0.0027 0.0275 0.0275
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0013 0.0073 0.0073
Schistosoma mansoni cation-transporting ATPase 0.0008 0.0003 0.0003
Plasmodium falciparum metacaspase 1 0.0053 0.0658 0.2932
Mycobacterium tuberculosis Two component sensor histidine kinase TrcS 0.0013 0.0073 0.1105
Trypanosoma brucei unspecified product 0.0019 0.0162 0.1918
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0162 0.0162
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.0658 0.1949
Onchocerca volvulus 0.0237 0.3362 1
Echinococcus multilocularis copper transporting ATPase 1 0.0008 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.001 0.0027 0.0053
Brugia malayi Probable DNA topoisomerase II 0.0013 0.0073 0.0153
Plasmodium vivax DNA gyrase subunit B, putative 0.0013 0.0073 0.0314
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.001 0.0027 0.0072
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0027 0.0027
Entamoeba histolytica hypothetical protein 0.0036 0.0407 0.1808
Plasmodium falciparum heat shock protein 90, putative 0.0027 0.027 0.1195
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0162 0.1918
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0111 0.0111
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0027 0.0027
Toxoplasma gondii heat shock protein 75, putative 0.0027 0.027 0.1645
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0053 0.0658 0.1949
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.007 0.007
Schistosoma mansoni caspase-3 (C14 family) 0.0198 0.2791 0.2791
Echinococcus multilocularis cation transporting ATPase 13A3 0.0008 0.0003 0.0003
Echinococcus granulosus cpg binding protein 0.003 0.0324 0.0324
Trypanosoma cruzi protein farnesyltransferase alpha subunit, putative 0.0042 0.049 0.5872
Giardia lamblia Pms1-like protein 0.0013 0.0073 0.0314
Schistosoma mansoni atpase class VI type 11c 0.0008 0.0003 0.0003
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0053 0.0658 0.1949
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0027 0.0027
Onchocerca volvulus Bile acid receptor homolog 0.001 0.0027 0.0072
Echinococcus multilocularis phospholipid transporting ATPase VA 0.0008 0.0003 0.0003
Toxoplasma gondii hypothetical protein 0.0042 0.049 0.3003
Leishmania major heat shock protein 83-1 0.0065 0.0833 1
Schistosoma mansoni polycystin 1-related 0.0023 0.0216 0.0216
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0111 0.0664
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.0587 0.127
Trypanosoma brucei metacaspase 0.0053 0.0658 0.7892
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0162 0.2504
Plasmodium vivax SET domain protein, putative 0.003 0.0326 0.1447
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.0027 0.0275 0.0591
Echinococcus granulosus cation transporting ATPase 13A3 0.0008 0.0003 0.0003
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0162 0.1918
Schistosoma mansoni lipoxygenase 0.0137 0.1895 0.1895
Toxoplasma gondii PPIC-type PPIASE domain-containing protein 0.001 0.0028 0.0154
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0027 0.0053
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0027 0.0053
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.001 0.0027 0.0053
Schistosoma mansoni ATPase 0.0008 0.0003 0.0003
Echinococcus granulosus protein prenyltransferase alpha subunit 0.0042 0.049 0.049
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0027 0.0027
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0027 0.0027
Schistosoma mansoni hypothetical protein 0.0036 0.0407 0.0407
Echinococcus granulosus protein quaking 0.0027 0.0278 0.0278
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0111 0.1299
Schistosoma mansoni type V p-type atpase isoform 0.0008 0.0003 0.0003
Brugia malayi isocitrate dehydrogenase 0.0016 0.0111 0.0235
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0162 0.1918
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0162 0.0162
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0275 0.0591
Echinococcus granulosus intermediate filament protein 0.0027 0.0275 0.0275
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0111 0.1299
Schistosoma mansoni heat shock protein 0.0065 0.0833 0.0833
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.0789 0.0789
Echinococcus multilocularis heat shock protein 0.0065 0.0833 0.0833
Trypanosoma cruzi metacaspase, putative 0.0053 0.0658 0.7892
Entamoeba histolytica DNA topoisomerase II, putative 0.0013 0.0073 0.0314
Plasmodium falciparum endoplasmin, putative 0.004 0.0464 0.2064
Wolbachia endosymbiont of Brugia malayi DNA gyrase, topoisomerase II, B subunit, GyrB 0.0013 0.0073 0.0741
Trypanosoma brucei DNA topoisomerase II alpha, putative 0.0013 0.0073 0.0846
Plasmodium vivax prenyltransferase alpha subunit, putative 0.016 0.2236 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0027 0.0053
Schistosoma mansoni lipoxygenase 0.0096 0.1289 0.1289
Echinococcus multilocularis lipoxygenase domain containing protein 0.0023 0.0216 0.0216
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0016 0.0111 0.0483
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0111 0.0235
Schistosoma mansoni ATPase 0.0008 0.0003 0.0003
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0027 0.0027
Echinococcus multilocularis phosphoserine phosphatase 0.0008 0.0003 0.0003
Trypanosoma brucei heat shock protein, putative 0.0065 0.0833 1
Mycobacterium ulcerans two component sensor kinase MprB 0.0013 0.0073 0.1105
Onchocerca volvulus 0.003 0.0326 0.0962
Plasmodium vivax heat shock protein 90, putative 0.0027 0.027 0.1195
Trypanosoma brucei heat shock protein, putative 0.0065 0.0833 1
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0013 0.0073 0.0209
Mycobacterium tuberculosis Two component sensor kinase [second part] 0.0013 0.0073 0.1105
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0162 0.0346
Schistosoma mansoni voltage-gated potassium channel 0.0083 0.1098 0.1098
Schistosoma mansoni microtubule-associated protein tau 0.0689 1 1
Mycobacterium ulcerans putative regultory protein 0.0013 0.0073 0.1105
Trypanosoma brucei Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0013 0.0073 0.0846
Echinococcus multilocularis lamin dm0 0.0027 0.0275 0.0275
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0027 0.0027
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0162 0.1918
Loa Loa (eye worm) hypothetical protein 0.0049 0.0605 0.1309
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0407 0.0407
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0033 0.0358 0.4273
Brugia malayi hypothetical protein 0.0236 0.3347 0.7282
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0198 0.2791 0.2791
Schistosoma mansoni endoplasmin 0.0065 0.0833 0.0833
Onchocerca volvulus 0.0029 0.03 0.0885
Echinococcus granulosus Pyruvate dehydrogenase lipoamide kinase 0.0013 0.0073 0.0073
Mycobacterium leprae PUTATIVE TWO COMPONENT SENSOR HISTIDINE KINASE SENX3 0.0013 0.0073 0.1105
Loa Loa (eye worm) hypothetical protein 0.0236 0.3347 0.7282
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.001 0.0028 0.0301
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0326 0.0326
Brugia malayi hypothetical protein 0.0088 0.1172 0.2544
Schistosoma mansoni caspase-7 (C14 family) 0.0053 0.0658 0.0658
Leishmania major peptidyl-prolyl cis-trans isomerase, putative 0.001 0.0028 0.0301
Echinococcus granulosus heat shock protein 0.0065 0.0833 0.0833
Trichomonas vaginalis heat shock protein, putative 0.0027 0.027 0.0794
Echinococcus multilocularis phosphoserine phosphatase 0.0008 0.0003 0.0003
Loa Loa (eye worm) doublecortin family protein 0.0023 0.0216 0.0464
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0162 0.1918
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0162 0.0162
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0162 0.2504
Chlamydia trachomatis DNA gyrase subunit B 0.0013 0.0073 1
Trichomonas vaginalis heat shock protein, putative 0.0052 0.0638 0.1891
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0033 0.0358 0.4273
Toxoplasma gondii histone lysine methyltransferase SET1 0.0055 0.0693 0.4256
Schistosoma mansoni nuclear hormone receptor 0.001 0.0027 0.0027
Onchocerca volvulus 0.0049 0.0605 0.179
Trypanosoma cruzi heat shock protein 85, putative 0.0065 0.0833 1
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0137 0.1895 0.1895
Trypanosoma brucei heat shock protein, putative 0.0065 0.0833 1
Trypanosoma brucei Protein prenyltransferase alpha subunit repeat, putative 0.0042 0.049 0.5872
Echinococcus multilocularis cpg binding protein 0.003 0.0324 0.0324
Trypanosoma cruzi metacaspase 5, putative 0.0053 0.0658 0.7892
Schistosoma mansoni hypothetical protein 0.0027 0.0278 0.0278
Toxoplasma gondii heat shock protein HSP90 0.0065 0.0833 0.5115
Schistosoma mansoni heat shock protein 0.0065 0.0833 0.0833
Brugia malayi Pre-SET motif family protein 0.0208 0.2941 0.6396
Brugia malayi tumor suppressor. 0.0321 0.4596 1
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0013 0.0073 0.0433
Giardia lamblia Grp94/Hsp90 0.0052 0.0638 0.2845
Brugia malayi Endoplasmin precursor 0.0065 0.0833 0.1806
Echinococcus multilocularis cation transporting atpase worm 0.0008 0.0003 0.0003
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.049 0.5872
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0137 0.1895 0.1895
Brugia malayi Hsp90 protein 0.0027 0.027 0.0581
Trichomonas vaginalis rotamase, putative 0.0033 0.0358 0.1055
Schistosoma mansoni hypothetical protein 0.0048 0.0587 0.0587
Loa Loa (eye worm) hypothetical protein 0.0012 0.0063 0.013
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.0027 0.027 0.027
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0053 0.0658 0.4036
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0027 0.0053
Echinococcus granulosus lipoxygenase domain containing protein 0.0023 0.0216 0.0216
Echinococcus granulosus caspase 3 0.0145 0.2012 0.2012
Leishmania major heat shock protein 83-1 0.0065 0.0833 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0111 0.0111
Loa Loa (eye worm) hypothetical protein 0.0053 0.0658 0.1425
Trypanosoma cruzi Heat shock protein 83, putative 0.0065 0.0833 1
Leishmania major hypothetical protein, conserved 0.0013 0.0073 0.0846
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0013 0.0073 0.0073
Echinococcus multilocularis dna polymerase eta 0.0045 0.0536 0.0536
Schistosoma mansoni pyruvate dehydrogenase 0.0013 0.0073 0.0073
Echinococcus multilocularis microtubule associated protein 2 0.0689 1 1
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0027 0.0053
Schistosoma mansoni thyroid hormone receptor 0.001 0.0027 0.0027
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0162 0.0474
Loa Loa (eye worm) hypothetical protein 0.0088 0.1172 0.2544
Schistosoma mansoni cation-transporting atpase worm 0.0008 0.0003 0.0003
Loa Loa (eye worm) prenyltransferase alpha subunit repeat containing protein 0.016 0.2236 0.4861
Treponema pallidum chemotaxis histidine kinase (cheA) 0.0013 0.0073 0.1105
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0326 0.0326
Plasmodium falciparum heat shock protein 90, putative 0.0027 0.027 0.1195
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0061 0.0773 0.0773
Plasmodium falciparum LCCL domain-containing protein 0.0023 0.0216 0.0954
Trypanosoma cruzi metacaspase 5, putative 0.0053 0.0658 0.7892
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0111 0.0111
Entamoeba histolytica hypothetical protein 0.0036 0.0407 0.1808
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0111 0.0111
Trichomonas vaginalis endoplasmin, putative 0.004 0.0464 0.1372
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0027 0.0053
Trypanosoma brucei unspecified product 0.0013 0.0074 0.0859
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0053 0.0658 0.1949
Trichomonas vaginalis mismatch repair protein Mlh1C (mutL homolog) 0.0013 0.0073 0.0209
Loa Loa (eye worm) prenyltransferase alpha subunit repeat containing protein 0.0042 0.049 0.106
Loa Loa (eye worm) heat shock protein 75 0.0027 0.027 0.0581
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0033 0.0358 0.4273
Brugia malayi CXXC zinc finger family protein 0.0029 0.03 0.0647
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0027 0.0053
Loa Loa (eye worm) tumor suppressor 0.0321 0.4596 1
Trypanosoma cruzi heat shock protein 90, putative 0.0038 0.0442 0.529
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0027 0.0053
Entamoeba histolytica protein farnesyltransferase alpha subunit, putative 0.016 0.2236 1
Echinococcus granulosus lipoxygenase domain containing protein 0.0023 0.0216 0.0216
Trypanosoma brucei DNA topoisomerase II beta, putative 0.0013 0.0073 0.0846
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0369 0.1089
Schistosoma mansoni cation-transporting atpase 13a1 (G-box binding protein) 0.0008 0.0003 0.0003
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0016 0.0111 0.1299
Mycobacterium tuberculosis Probable two component sensor kinase 0.0013 0.0073 0.1105
Echinococcus granulosus dnaJ subfamily B 0.0408 0.5878 0.5878
Trypanosoma brucei heat shock protein, putative 0.0065 0.0833 1
Mycobacterium ulcerans two component sensor histidine kinase SenX3 0.0013 0.0073 0.1105
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0326 0.0326
Onchocerca volvulus Protein ultraspiracle homolog 0.001 0.0027 0.0072
Trichomonas vaginalis sensory transduction histidine kinase, putative 0.0013 0.0073 0.0209
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0027 0.0027
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0027 0.0053
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0027 0.0027
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0053 0.0658 0.1949
Echinococcus granulosus survival motor neuron protein 1 0.0236 0.3347 0.3347
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0052 0.0638 1
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0027 0.0027
Mycobacterium tuberculosis DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.0013 0.0073 0.1105
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0027 0.0027
Trichomonas vaginalis heat shock protein, putative 0.0065 0.0833 0.2469
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0053 0.0658 0.1949
Echinococcus multilocularis potassium voltage gated channel subfamily A 0.0079 0.1045 0.1045
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0053 0.0658 0.1949
Plasmodium vivax multidomain scavenger receptor, putative 0.0023 0.0216 0.0954
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0026 0.0026
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0162 0.1918
Trypanosoma brucei developmentally regulated phosphoprotein 0.0013 0.0073 0.0846
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0027 0.0027
Giardia lamblia Heat shock protein HSP 90-alpha 0.0052 0.0638 0.2845
Onchocerca volvulus 0.001 0.0027 0.0072
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0111 0.0111
Brugia malayi intermediate filament protein 0.0027 0.0275 0.0591
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0162 0.1918
Echinococcus multilocularis survival motor neuron protein 1 0.0236 0.3347 0.3347
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0162 0.1918
Trypanosoma brucei heat shock protein, putative 0.0065 0.0833 1
Brugia malayi heat shock protein 90 0.0065 0.0833 0.1806
Trypanosoma brucei heat shock protein 84, putative 0.0027 0.027 0.3215
Schistosoma mansoni caspase-7 (C14 family) 0.0198 0.2791 0.2791
Loa Loa (eye worm) heat shock protein 90 0.0065 0.0833 0.1806
Loa Loa (eye worm) endoplasmin 0.0065 0.0833 0.1806
Toxoplasma gondii hypothetical protein 0.0119 0.1625 1
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0053 0.0658 0.4036
Onchocerca volvulus 0.0023 0.0216 0.0634
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0162 0.0162
Echinococcus multilocularis geranylgeranyl transferase type 2 subunit alpha 0.0042 0.049 0.049
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0326 0.0326
Plasmodium vivax hypothetical protein, conserved 0.0053 0.0658 0.2932
Brugia malayi hypothetical protein 0.0027 0.0278 0.0599
Trypanosoma brucei Heat shock protein 83, putative 0.0065 0.0833 1
Plasmodium falciparum metacaspase-like protein 0.0053 0.0658 0.2932
Trichomonas vaginalis heat shock protein, putative 0.0052 0.0638 0.1891
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0013 0.0073 0.0433
Trypanosoma brucei Metacaspase-4 0.0053 0.0658 0.7892
Leishmania major DNA polymerase eta, putative 0.0045 0.0536 0.6422
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0027 0.0053
Onchocerca volvulus 0.0048 0.0587 0.1737
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0275 0.0591
Echinococcus multilocularis expressed protein 0.0033 0.0369 0.0369
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0033 0.0358 0.4273
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0027 0.0027
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0053 0.0658 0.4036
Brugia malayi Doublecortin family protein 0.0023 0.0216 0.0464
Schistosoma mansoni rab6-interacting 0.0023 0.0216 0.0216
Trypanosoma cruzi metacaspase, putative 0.0053 0.0658 0.7892
Plasmodium falciparum heat shock protein 90 0.0065 0.0833 0.3715
Trichomonas vaginalis heat shock protein, putative 0.0052 0.0638 0.1891
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.03 0.0647
Leishmania major heat shock protein 83-1 0.0065 0.0833 1
Echinococcus multilocularis Tetracycline resistance leader peptide, TetL 0.0008 0.0003 0.0003
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0208 0.2941 0.6396
Plasmodium falciparum geranylgeranyl transferase type-2 subunit alpha, putative 0.0042 0.049 0.2181
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0027 0.0027
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0027 0.0027
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0027 0.0053
Entamoeba histolytica 90 kDa heat shock protein, putative 0.0027 0.027 0.1195
Echinococcus granulosus lamin dm0 0.0027 0.0275 0.0275
Trypanosoma brucei heat shock protein, putative 0.0065 0.0833 1
Echinococcus granulosus protein farnesyltransferase alpha subunit 0.016 0.2236 0.2236
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.001 0.0028 0.0301
Trypanosoma cruzi metacaspase, putative 0.0053 0.0658 0.7892
Mycobacterium ulcerans two component regulator - sensor kinase 0.0013 0.0073 0.1105
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0027 0.0027
Echinococcus granulosus potassium voltage gated channel subfamily A 0.0083 0.1098 0.1098
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0111 0.0235
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0326 0.0326
Brugia malayi Protein prenyltransferase alpha subunit repeat containing protein 0.016 0.2236 0.4861
Schistosoma mansoni thyroid hormone receptor 0.001 0.0027 0.0027
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0074 0.0859
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0013 0.0073 0.0209
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0027 0.0053
Echinococcus granulosus calcium transporting ATPase type 2C member 0.0008 0.0003 0.0003
Brugia malayi hypothetical protein 0.0036 0.0407 0.0879
Trypanosoma brucei metacaspase MCA2 0.0053 0.0658 0.7892
Schistosoma mansoni rab6-interacting 0.0023 0.0216 0.0216
Brugia malayi DNA topoisomerase II, alpha isozyme 0.0013 0.0073 0.0153
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0042 0.049 0.145
Echinococcus multilocularis heat shock protein 90 0.0052 0.0638 0.0638
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0111 0.0111
Trypanosoma cruzi Protein prenyltransferase alpha subunit repeat, putative 0.0042 0.049 0.5872
Loa Loa (eye worm) hypothetical protein 0.0013 0.0073 0.0153
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0013 0.0073 1
Echinococcus multilocularis heat shock protein 90 0.0065 0.0833 0.0833
Trypanosoma brucei metacaspase MCA3 0.0053 0.0658 0.7892
Plasmodium falciparum DNA topoisomerase VI, b subunit, putative 0.0013 0.0073 0.0314
Schistosoma mansoni hypothetical protein 0.0408 0.5878 0.5878
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0407 0.0407
Wolbachia endosymbiont of Brugia malayi signal transduction histidine kinase and receiver 0.0013 0.0073 0.0741
Loa Loa (eye worm) hypothetical protein 0.001 0.0027 0.0053
Echinococcus multilocularis tumor protein p63 0.0337 0.4835 0.4835
Mycobacterium ulcerans two component sensor histidine kinase PrrB 0.0013 0.0073 0.1105
Plasmodium vivax DNA topoisomerase II, putative 0.0013 0.0073 0.0314
Giardia lamblia Rab geranylgeranyltransferase 0.016 0.2236 1
Schistosoma mansoni coup transcription factor 0.001 0.0027 0.0027
Echinococcus multilocularis phosphoserine phosphatase 0.0008 0.0003 0.0003
Mycobacterium tuberculosis Probable sensor protein KdpD 0.0013 0.0073 0.1105
Trypanosoma brucei heat shock protein 90, putative 0.0065 0.0833 1
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0162 0.1918
Loa Loa (eye worm) hypothetical protein 0.0023 0.0216 0.0464
Brugia malayi Cell death protein 3 precursor 0.0053 0.0658 0.1425
Leishmania major heat shock protein 83-1 0.0065 0.0833 1
Echinococcus multilocularis lamin 0.0027 0.0275 0.0275
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0111 0.0664
Trypanosoma cruzi heat shock protein 90, putative 0.0065 0.0833 1
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0027 0.0053
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0162 0.1918
Echinococcus granulosus phospholipid transporting ATPase IIB 0.0008 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.016 0.2236 0.4861
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0052 0.0638 0.0638
Entamoeba histolytica heat shock protein 90, putative 0.0065 0.0833 0.3715
Mycobacterium leprae Probable two-component sensor kinase 0.0013 0.0073 0.1105
Echinococcus granulosus caspase 0.0198 0.2791 0.2791
Plasmodium vivax heat shock protein, putative 0.0027 0.027 0.1195
Leishmania major heat shock protein 83-1 0.0065 0.0833 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0162 0.1918
Schistosoma mansoni copper ABC transporter ATPase 0.0008 0.0003 0.0003
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0162 0.2504
Echinococcus granulosus sarco:endoplasmic reticulum calcium ATPase 0.0008 0.0003 0.0003
Mycobacterium leprae TWO COMPONENT SENSOR HISTIDINE KINASE PRRB 0.0013 0.0073 0.1105
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0027 0.0053
Echinococcus multilocularis protein quaking 0.0027 0.0278 0.0278

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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