TDR Targets

Basic information

Technical information

TDR Targets ID: 763449
Name: 1-(3-ethoxy-4-hydroxyphenyl)-2-(5-methyl-1,3, 4-thiadiazol-2-yl)-1H-chromeno[2,3-c]pyrrole- 3,9-dione
MW: 435.452 | Formula: C22H17N3O5S
H donors: 1 H acceptors: 5 LogP: 3.21 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: CCOc1cc(ccc1O)C1N(c2nnc(s2)C)C(=O)c2c1c(=O)c1c(o2)cccc1
InChi: 1S/C22H17N3O5S/c1-3-29-16-10-12(8-9-14(16)26)18-17-19(27)13-6-4-5-7-15(13)30-20(17)21(28)25(18)22-24-23-11(2)31-22/h4-10,18,26H,3H2,1-2H3
InChiKey: PVCKEFCVRDEMNU-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

1-(3-ethoxy-4-hydroxy-phenyl)-2-(5-methyl-1,3,4-thiadiazol-2-yl)-1H-chromeno[2,3-c]pyrrole-3,9-dione
1-(3-ethoxy-4-hydroxy-phenyl)-2-(5-methyl-1,3,4-thiadiazol-2-yl)-1H-chromeno[2,3-c]pyrrole-3,9-quinone
AF-399/42217460

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	sugar transporter	0.0015	0.0217	0.0894
Mycobacterium ulcerans	fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT	0.0015	0.0217	0.5239
Mycobacterium tuberculosis	Probable cytochrome P450 monooxygenase 142 Cyp142	0.0007	0.0043	0.1288
Trypanosoma brucei	cytochrome P450, putative	0.0007	0.0043	0.06
Plasmodium vivax	hexose transporter	0.0108	0.2266	0.2253
Mycobacterium ulcerans	cytochrome P450 187A4 Cyp187A4	0.0007	0.0043	0.1038
Plasmodium falciparum	calcium-dependent protein kinase 3	0.0033	0.0612	0.0597
Trypanosoma brucei	calcium/calmodulin-dependent protein kinase, putative	0.0033	0.0611	0.855
Echinococcus granulosus	solute carrier family 22	0.0015	0.0217	0.0894
Brugia malayi	hypothetical protein	0.0015	0.0217	0.0538
Trichomonas vaginalis	glucose transporter, putative	0.0033	0.0621	0.1701
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0217	0.0594
Trypanosoma cruzi	Lanosterol 14-alpha demethylase	0.0007	0.0043	0.06
Mycobacterium tuberculosis	Probable cytochrome P450 128 Cyp128	0.0007	0.0043	0.1288
Trypanosoma cruzi	hexose transporter, putative	0.0033	0.0621	0.868
Plasmodium falciparum	isocitrate dehydrogenase [NADP], mitochondrial	0.0016	0.0227	0.0211
Mycobacterium ulcerans	cytochrome P450 191A3 Cyp191A3	0.0007	0.0043	0.1038
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0217	0.0594
Plasmodium falciparum	mitogen-activated protein kinase 2	0.0174	0.3734	0.3724
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0217	0.0594
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0016	0.0227	0.0938
Mycobacterium tuberculosis	Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM)	0.0007	0.0043	0.1288
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0217	0.0538
Toxoplasma gondii	sugar transporter ST2	0.0015	0.0217	0.0327
Mycobacterium ulcerans	cytochrome P450 51B1 Cyp51B1	0.0007	0.0043	0.1038
Schistosoma mansoni	hypothetical protein	0.0007	0.0043	0.0121
Mycobacterium ulcerans	cytochrome P450 140A5 Cyp140A5	0.0007	0.0043	0.1038
Onchocerca volvulus		0.0015	0.0217	0.5
Trichomonas vaginalis	prolyl-tRNA synthetase, putative	0.0032	0.0597	0.1635
Giardia lamblia	Lysyl-tRNA synthetase	0.0024	0.0414	0.6849
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0217	0.0594
Wolbachia endosymbiont of Brugia malayi	major facilitator superfamily permease	0.0015	0.0217	1
Mycobacterium ulcerans	cytochrome P450 150A6 Cyp150A6	0.0007	0.0043	0.1038
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0217	0.0594
Trypanosoma cruzi	glucose transporter, putative	0.0015	0.0217	0.303
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0217	0.0538
Mycobacterium ulcerans	cytochrome P450 123A3 Cyp123A3	0.0007	0.0043	0.1038
Trypanosoma brucei	glycyl-tRNA synthetase, putative	0.0006	0.0016	0.0218
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0108	0.2266	1
Brugia malayi	Sugar transporter family protein	0.0108	0.2266	0.6014
Trichomonas vaginalis	sugar transporter, putative	0.0033	0.0621	0.1701
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0217	0.0538
Onchocerca volvulus		0.0015	0.0217	0.5
Echinococcus multilocularis	General substrate transporter	0.0093	0.193	0.851
Onchocerca volvulus	Putative transporter	0.0015	0.0217	0.5
Plasmodium vivax	CDK-related protein kinase 6, putative	0.0457	1	1
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0217	0.0594
Treponema pallidum	prolyl-tRNA synthetase	0.0011	0.0134	1
Echinococcus granulosus	synaptic vesicle 2 protein	0.0015	0.0217	0.0894
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0108	0.2266	1
Schistosoma mansoni	sugar transporter	0.0015	0.0217	0.0894
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0217	0.0594
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0217	0.0538
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0217	0.0538
Echinococcus multilocularis	lysyl tRNA synthetase	0.0024	0.0414	0.1769
Loa Loa (eye worm)	calcium/calmodulin-dependent protein kinase ID	0.0033	0.0611	0.1593
Echinococcus granulosus	calcium dependent protein kinase	0.0031	0.0566	0.2448
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0033	0.0611	0.2648
Echinococcus multilocularis		0.0007	0.0043	0.0121
Mycobacterium tuberculosis	Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP)	0.0016	0.0227	0.6798
Brugia malayi	cytochrome P450	0.0007	0.0043	0.0073
Trypanosoma brucei	threonyl-tRNA synthetase, putative	0.0006	0.0016	0.0218
Mycobacterium tuberculosis	Probable cytochrome P450 125 Cyp125	0.0007	0.0043	0.1288
Echinococcus granulosus	cytochrome P450 2K1	0.0007	0.0043	0.0121
Plasmodium vivax	sugar transporter, putative	0.0015	0.0217	0.0201
Plasmodium vivax	lysine--tRNA ligase, putative	0.0024	0.0414	0.0399
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0217	0.0538
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0217	0.0594
Trichomonas vaginalis	glucose transporter, putative	0.0033	0.0621	0.1701
Trypanosoma cruzi	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0016	0.0227	0.3169
Echinococcus multilocularis	synaptic vesicle 2 protein	0.0015	0.0217	0.0894
Mycobacterium ulcerans	prolyl-tRNA synthetase	0.0011	0.0134	0.3243
Mycobacterium tuberculosis	Probable cytochrome P450 124 Cyp124	0.0007	0.0043	0.1288
Plasmodium vivax	calcium-dependent protein kinase 4, putative	0.0033	0.0612	0.0597
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0217	0.0594
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0033	0.0611	0.2648
Echinococcus granulosus	General substrate transporter	0.0093	0.193	0.851
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 2 LysX	0.002	0.0333	1
Giardia lamblia	Hexose transporter	0.0015	0.0217	0.346
Trypanosoma brucei	sugar transporter, putative	0.0015	0.0217	0.303
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0108	0.2266	1
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0033	0.0621	0.868
Onchocerca volvulus		0.0015	0.0217	0.5
Mycobacterium ulcerans	cytochrome P450 188A3 Cyp188A3	0.0007	0.0043	0.1038
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0217	0.0594
Onchocerca volvulus		0.0015	0.0217	0.5
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0033	0.0611	0.2648
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0217	0.0594
Brugia malayi	Major Facilitator Superfamily protein	0.0015	0.0217	0.0538
Loa Loa (eye worm)	cytochrome P450 family protein	0.0007	0.0043	0.0073
Trichomonas vaginalis	myo-inositol transporter, putative	0.0015	0.0217	0.0594
Brugia malayi	Bifunctional aminoacyl-tRNA synthetase	0.0032	0.0597	0.1553
Leishmania major	glucose transporter/membrane transporter D2, putative	0.0033	0.0621	0.868
Trypanosoma brucei	glucose transporter, putative	0.0033	0.0621	0.868
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0217	0.0594
Trypanosoma brucei	glucose transporter, putative	0.0033	0.0621	0.868
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0217	0.0594
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0217	0.0594
Loa Loa (eye worm)	cytochrome P450	0.0007	0.0043	0.0073
Trypanosoma brucei	glucose transporter, putative	0.0033	0.0621	0.868
Mycobacterium tuberculosis	Probable cytochrome P450 141 Cyp141	0.0007	0.0043	0.1288
Mycobacterium ulcerans	cytochrome P450 185A4 Cyp185A4	0.0007	0.0043	0.1038
Toxoplasma gondii	protein kinase, putative	0.0304	0.6617	1
Mycobacterium ulcerans	cytochrome P450 189A7 Cyp189A7	0.0007	0.0043	0.1038
Leishmania major	glucose transporter, lmgt3	0.0033	0.0621	0.868
Loa Loa (eye worm)	cytochrome P450 family protein	0.0007	0.0043	0.0073
Toxoplasma gondii	calcium-dependent protein kinase CDPK2B	0.0033	0.0612	0.0925
Trypanosoma brucei	isocitrate dehydrogenase, putative	0.0016	0.0227	0.3169
Trypanosoma cruzi	sugar transporter, putative	0.0015	0.0217	0.303
Onchocerca volvulus		0.0015	0.0217	0.5
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0217	0.0594
Mycobacterium tuberculosis	Possible cytochrome P450 126 Cyp126	0.0007	0.0043	0.1288
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0016	0.0227	0.0938
Schistosoma mansoni	hypothetical protein	0.0108	0.2266	1
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0108	0.2266	1
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0217	0.0538
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0038	0.0715	1
Trypanosoma cruzi	Lanosterol 14-alpha demethylase	0.0007	0.0043	0.06
Loa Loa (eye worm)	hypothetical protein	0.0175	0.3757	1
Trypanosoma brucei	glucose transporter 1E	0.0033	0.0621	0.868
Leishmania major	protein kinase, putative	0.0033	0.0611	0.855
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0217	0.0594
Loa Loa (eye worm)	sugar transporter	0.0015	0.0217	0.0538
Leishmania major	threonyl-tRNA synthetase, putative	0.0006	0.0016	0.0218
Trypanosoma cruzi	threonyl-tRNA synthetase, putative	0.0006	0.0016	0.0218
Plasmodium vivax	isocitrate dehydrogenase [NADP], mitochondrial, putative	0.0016	0.0227	0.0211
Mycobacterium ulcerans	sugar transporter	0.0015	0.0217	0.5239
Mycobacterium ulcerans	threonyl-tRNA synthetase	0.0006	0.0016	0.0377
Schistosoma mansoni	glucose transport protein	0.0108	0.2266	1
Echinococcus multilocularis	calcium activated potassium channel	0.0007	0.0033	0.0078
Onchocerca volvulus		0.0015	0.0217	0.5
Trypanosoma brucei	lysyl-tRNA synthetase, putative	0.0024	0.0414	0.5783
Trypanosoma brucei	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0016	0.0227	0.3169
Mycobacterium tuberculosis	Cytochrome P450 121 Cyp121	0.0007	0.0043	0.1288
Brugia malayi	lysyl-tRNA synthetase	0.0024	0.0414	0.1064
Onchocerca volvulus		0.0015	0.0217	0.5
Plasmodium falciparum	calcium-dependent protein kinase 4	0.0033	0.0612	0.0597
Mycobacterium ulcerans	cytochrome P450 144A4 Cyp144A4	0.0007	0.0043	0.1038
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0217	0.0594
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0217	0.0594
Trypanosoma brucei	bifunctional aminoacyl-tRNA synthetase, putative	0.0038	0.0715	1
Onchocerca volvulus		0.0015	0.0217	0.5
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0217	0.0594
Mycobacterium leprae	Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase) (ThrRS) (Threonine-tRNA ligase)	0.0006	0.0016	0.0262
Echinococcus multilocularis	solute carrier family 22	0.0015	0.0217	0.0894
Trichomonas vaginalis	conserved hypothetical protein	0.0033	0.0621	0.1701
Toxoplasma gondii	prolyl-tRNA synthetase (ProRS)	0.0038	0.0715	0.1081
Leishmania major	cytochrome p450-like protein	0.0007	0.0043	0.06
Brugia malayi	Cam kinase protein 1	0.0033	0.0611	0.1593
Schistosoma mansoni	lysyl-tRNA synthetase	0.0024	0.0414	0.1769
Toxoplasma gondii	threonyl-tRNA synthetase family protein	0.0006	0.0016	0.0024
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0024	0.0414	0.1133
Entamoeba histolytica	hypothetical protein	0.0024	0.0414	0.6679
Mycobacterium ulcerans	cytochrome P450 187A5 Cyp187A5	0.0007	0.0043	0.1038
Brugia malayi	Cytochrome P450 family protein	0.0007	0.0043	0.0073
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0217	0.0594
Echinococcus granulosus	Sugar transporter ERD6 protein	0.0015	0.0217	0.0894
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0217	0.0538
Trichomonas vaginalis	sugar transporter, putative	0.0033	0.0621	0.1701
Plasmodium falciparum	hexose transporter	0.0108	0.2266	0.2253
Plasmodium falciparum	major facilitator superfamily domain-containing protein, putative	0.0015	0.0217	0.0201
Brugia malayi	Cytochrome P450 family protein	0.0007	0.0043	0.0073
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0016	0.0227	0.0938
Mycobacterium ulcerans	cytochrome P450 142A3 Cyp142A3	0.0007	0.0043	0.1038
Mycobacterium leprae	putative cytochrome p450	0.0007	0.0043	0.072
Brugia malayi	Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog	0.0175	0.3757	1
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0217	0.0538
Leishmania major	glucose transporter, lmgt1	0.0033	0.0621	0.868
Brugia malayi	Calcium/calmodulin-dependent protein kinase type II alpha chain	0.0033	0.0611	0.1593
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type 1	0.0033	0.0611	0.2648
Trypanosoma cruzi	hexose transporter, putative	0.0018	0.0286	0.3994
Mycobacterium tuberculosis	Probable conserved integral membrane transport protein	0.0015	0.0217	0.6499
Trypanosoma brucei	glucose transporter, putative	0.0033	0.0621	0.868
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0217	0.0594
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0217	0.0594
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0217	0.0594
Onchocerca volvulus		0.0015	0.0217	0.5
Onchocerca volvulus		0.0015	0.0217	0.5
Mycobacterium ulcerans	cytochrome P450 108B4 Cyp108B4	0.0007	0.0043	0.1038
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0033	0.0611	0.2648
Toxoplasma gondii	transporter, major facilitator family protein	0.0015	0.0217	0.0327
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.002	0.0333	1
Brugia malayi	isocitrate dehydrogenase	0.0016	0.0227	0.0564
Toxoplasma gondii	calcium-dependent protein kinase CDPK2A	0.0033	0.0612	0.0925
Schistosoma mansoni	glucose transport protein	0.0108	0.2266	1
Trichomonas vaginalis	threonyl-tRNA synthetase, putative	0.0006	0.0016	0.0043
Trichomonas vaginalis	sugar transporter, putative	0.0033	0.0621	0.1701
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0217	0.0594
Entamoeba histolytica	protein kinase, putative	0.0033	0.0611	1
Mycobacterium tuberculosis	Possible cytochrome P450 135A1 Cyp135A1	0.0007	0.0043	0.1288
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0463	0.1195
Plasmodium falciparum	calcium-dependent protein kinase 2	0.0033	0.0612	0.0597
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0217	0.0594
Schistosoma mansoni	nuclear transcription factor X-box binding 1 (nfx1)	0.0015	0.0217	0.0894
Trichomonas vaginalis	glucose transporter, putative	0.0015	0.0217	0.0594
Loa Loa (eye worm)	bifunctional aminoacyl-tRNA synthetase	0.0013	0.0175	0.0426
Trypanosoma cruzi	cytochrome P450, putative	0.0007	0.0043	0.06
Onchocerca volvulus		0.0015	0.0217	0.5
Chlamydia trachomatis	lysine--tRNA ligase	0.0024	0.0414	1
Brugia malayi	hypothetical protein	0.0015	0.0217	0.0538
Mycobacterium ulcerans	sugar-transport integral membrane protein SugI	0.0015	0.0217	0.5239
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0217	0.0594
Mycobacterium tuberculosis	Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter)	0.0015	0.0217	0.6499
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0033	0.0611	0.2648
Brugia malayi	Sugar transporter family protein	0.0015	0.0217	0.0538
Mycobacterium tuberculosis	Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase)(ThrRS) (threonine-tRNA ligase)	0.0006	0.0016	0.0468
Mycobacterium tuberculosis	Probable cytochrome P450 138 Cyp138	0.0007	0.0043	0.1288
Trypanosoma cruzi	lysyl-tRNA synthetase, putative	0.0024	0.0414	0.5783
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0217	0.0594
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0024	0.0414	1
Mycobacterium ulcerans	cytochrome P450 125A7 Cyp125A7	0.0007	0.0043	0.1038
Leishmania major	lanosterol 14-alpha-demethylase, putative	0.0007	0.0043	0.06
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0217	0.0594
Plasmodium falciparum	proline--tRNA ligase	0.0038	0.0715	0.0701
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0015	0.0217	0.0538
Trypanosoma cruzi	hexose transporter, putative	0.0015	0.0217	0.303
Loa Loa (eye worm)	CYP4Cod1	0.0007	0.0043	0.0073
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0217	0.0538
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0217	0.0594
Trichomonas vaginalis	CAMK family protein kinase	0.0033	0.0611	0.1675
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0414	0.1064
Echinococcus granulosus	solute carrier family 22	0.0015	0.0217	0.0894
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0217	0.0594
Schistosoma mansoni	lysyl-tRNA synthetase	0.0024	0.0414	0.1769
Trichomonas vaginalis	conserved hypothetical protein	0.0033	0.0621	0.1701
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0217	0.0538
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0033	0.0621	0.868
Echinococcus multilocularis	glutamyl tRNA synthetase cytoplasmic	0.0032	0.0597	0.2583
Mycobacterium tuberculosis	Probable cytochrome P450 123 Cyp123	0.0007	0.0043	0.1288
Trichomonas vaginalis	sugar transport protein, putative	0.0015	0.0217	0.0594
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0015	0.0217	0.0538
Trypanosoma cruzi	isocitrate dehydrogenase, putative	0.0016	0.0227	0.3169
Toxoplasma gondii	isocitrate dehydrogenase	0.0016	0.0227	0.0343
Brugia malayi	major facilitator superfamily protein	0.0015	0.0217	0.0538
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0217	0.0538
Schistosoma mansoni	sugar transporter	0.0015	0.0217	0.0894
Trypanosoma cruzi	hexose transporter, putative	0.0033	0.0621	0.868
Leishmania major	glucose transporter, lmgt2	0.0033	0.0621	0.868
Echinococcus multilocularis	solute carrier family 2, facilitated glucose	0.0108	0.2266	1
Trypanosoma cruzi	cytochrome p450-like protein, putative	0.0007	0.0043	0.06
Plasmodium vivax	calcium-dependent protein kinase 3, putative	0.0033	0.0612	0.0597
Echinococcus granulosus	solute carrier family 22	0.0015	0.0217	0.0894
Loa Loa (eye worm)	isocitrate dehydrogenase	0.0016	0.0227	0.0564
Mycobacterium tuberculosis	Probable cytochrome P450 140 Cyp140	0.0007	0.0043	0.1288
Brugia malayi	Cytochrome P450 family protein	0.0007	0.0043	0.0073
Brugia malayi	Major Facilitator Superfamily protein	0.0015	0.0217	0.0538
Echinococcus multilocularis	solute carrier family 22	0.0015	0.0217	0.0894
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0033	0.0611	0.2648
Onchocerca volvulus		0.0015	0.0217	0.5
Echinococcus multilocularis	solute carrier family 22	0.0015	0.0217	0.0894
Echinococcus granulosus	glutamyl tRNA synthetase cytoplasmic	0.0032	0.0597	0.2583
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0217	0.0594
Echinococcus granulosus	calcium activated potassium channel	0.0007	0.0033	0.0078
Mycobacterium ulcerans	glycyl-tRNA synthetase	0.0006	0.0016	0.0377
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0021	0.0348	0.0953
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0024	0.0414	1
Mycobacterium tuberculosis	Possible cytochrome P450 135B1 Cyp135B1	0.0007	0.0043	0.1288
Mycobacterium leprae	Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.002	0.0333	0.5587
Leishmania major	cytochrome p450-like protein	0.0007	0.0043	0.06
Leishmania major	hypothetical protein, conserved	0.0015	0.0217	0.303
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0217	0.0538
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0032	0.0597	0.2583
Echinococcus multilocularis	isocitrate dehydrogenase	0.0016	0.0227	0.0938
Echinococcus multilocularis	calcium dependent protein kinase	0.0031	0.0566	0.2448
Trypanosoma cruzi	hexose transporter, putative	0.0033	0.0621	0.868
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0217	0.0594
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0032	0.0597	0.2583
Trypanosoma cruzi	cytochrome P450, putative	0.0007	0.0043	0.06
Toxoplasma gondii	facilitative glucose transporter GT1	0.0108	0.2266	0.3424
Echinococcus multilocularis	isocitrate dehydrogenase 2 (NADP+)	0.0016	0.0227	0.0938
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0611	0.1593
Onchocerca volvulus		0.0015	0.0217	0.5
Toxoplasma gondii	sugar transporter ST1	0.0015	0.0217	0.0327
Mycobacterium leprae	Possible lysyl-tRNA synthetase 2 LysX	0.0024	0.0414	0.6932
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0033	0.0611	0.2648
Plasmodium falciparum	calcium-dependent protein kinase 5	0.0033	0.0612	0.0597
Trypanosoma brucei	myo-inositol/proton symporter (MIT)	0.0015	0.0217	0.303
Brugia malayi	Isocitrate dehydrogenase	0.0016	0.0227	0.0564
Schistosoma mansoni	protein kinase	0.0033	0.0611	0.2648
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0108	0.2266	1
Trypanosoma brucei	glucose transporter, putative	0.0033	0.0621	0.868
Brugia malayi	Cytochrome P450 family protein	0.0007	0.0043	0.0073
Chlamydia trachomatis	proline--tRNA ligase	0.0011	0.0134	0.2978
Trypanosoma brucei	glucose transporter, putative	0.0033	0.0621	0.868
Onchocerca volvulus		0.0015	0.0217	0.5
Toxoplasma gondii	isocitrate dehydrogenase	0.0016	0.0227	0.0343
Brugia malayi	hypothetical protein	0.0015	0.0217	0.0538
Schistosoma mansoni	sugar transporter	0.0015	0.0217	0.0894
Leishmania major	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0016	0.0227	0.3169
Echinococcus granulosus	lysyl tRNA synthetase	0.0024	0.0414	0.1769
Mycobacterium ulcerans	cytochrome P450 143A4 Cyp143A4	0.0007	0.0043	0.1038
Toxoplasma gondii	cytochrome p450 superfamily protein	0.0007	0.0043	0.0065
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0217	0.0594
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0108	0.2266	1
Trichomonas vaginalis	conserved hypothetical protein	0.017	0.3651	1
Schistosoma mansoni	protein kinase	0.0033	0.0611	0.2648
Mycobacterium tuberculosis	Probable cytochrome P450 143 Cyp143	0.0007	0.0043	0.1288
Plasmodium vivax	calcium-dependent protein kinase 1, putative	0.0033	0.0612	0.0597
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0038	0.0715	1
Onchocerca volvulus		0.0015	0.0217	0.5
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0217	0.0594
Mycobacterium tuberculosis	Probable cytochrome P450 136 Cyp136	0.0007	0.0043	0.1288
Echinococcus multilocularis	solute carrier family 22	0.0015	0.0217	0.0894
Mycobacterium ulcerans	cytochrome P450 124A1, Cyp124A1	0.0007	0.0043	0.1038
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0217	0.0538
Toxoplasma gondii	calcium-dependent protein kinase CDPK3	0.0033	0.0612	0.0925
Plasmodium vivax	mitogen-activated protein kinase 2, putative	0.0174	0.3734	0.3724
Plasmodium falciparum	protein kinase 7	0.0304	0.6617	0.6612
Mycobacterium ulcerans	cytochrome p450 150 cyp150	0.0007	0.0043	0.1038
Plasmodium vivax	calcium-dependent protein kinase, putative	0.0033	0.0612	0.0597
Entamoeba histolytica	protein kinase, putative	0.0033	0.0611	1
Brugia malayi	Sugar transporter family protein	0.0015	0.0217	0.0538
Mycobacterium ulcerans	cytochrome P450 143A3 Cyp143A3	0.0007	0.0043	0.1038
Trypanosoma brucei	glucose transporter, putative	0.0033	0.0621	0.868
Brugia malayi	bifunctional aminoacyl-tRNA synthetase	0.0032	0.0597	0.1553
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0108	0.2266	1
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0217	0.0538
Mycobacterium tuberculosis	Probable cytochrome P450 139 Cyp139	0.0007	0.0043	0.1288
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0217	0.0594
Trypanosoma cruzi	threonyl-tRNA synthetase, putative	0.0006	0.0016	0.0218
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0038	0.0715	1
Schistosoma mansoni	NADP-specific isocitrate dehydrogenase	0.0016	0.0227	0.0938
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0217	0.0594
Toxoplasma gondii	sugar transporter ST3	0.0015	0.0217	0.0327
Mycobacterium leprae	Conserved hypothetical protein	0.0007	0.0043	0.072
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0038	0.0715	1
Onchocerca volvulus		0.0015	0.0217	0.5
Echinococcus granulosus	solute carrier family 22	0.0015	0.0217	0.0894
Echinococcus granulosus	NADP dependent isocitrate dehydrogenase	0.0016	0.0227	0.0938
Mycobacterium ulcerans	cytochrome P450 126A3 Cyp126A3	0.0007	0.0043	0.1038
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0217	0.0594
Schistosoma mansoni	glucose transporter	0.0015	0.0217	0.0894
Toxoplasma gondii	glycyl-tRNA synthetase	0.0006	0.0016	0.0024
Schistosoma mansoni	glucose transport protein	0.0108	0.2266	1
Mycobacterium tuberculosis	Probable cytochrome P450 132 Cyp132	0.0007	0.0043	0.1288
Schistosoma mansoni	protein kinase	0.0033	0.0611	0.2648
Trypanosoma cruzi	hexose transporter	0.0033	0.0621	0.868
Loa Loa (eye worm)	cytochrome P450 family protein	0.0007	0.0043	0.0073
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0033	0.0621	0.868
Entamoeba histolytica	prolyl-tRNA synthetase, putative	0.0032	0.0597	0.9752
Schistosoma mansoni	serine/threonine protein kinase	0.0033	0.0611	0.2648
Giardia lamblia	Prolyl-tRNA synthetase	0.0032	0.0597	1
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0597	0.1553
Plasmodium falciparum	calcium-dependent protein kinase 1	0.0033	0.0612	0.0597
Leishmania major	lysyl-tRNA synthetase, putative	0.0024	0.0414	0.5783
Plasmodium vivax	proline--tRNA ligase, putative	0.0038	0.0715	0.0701
Trypanosoma brucei	glucose transporter 2A	0.0033	0.0621	0.868
Mycobacterium tuberculosis	Probable cytochrome P450 137 Cyp137	0.0007	0.0043	0.1288
Brugia malayi	major facilitator superfamily protein	0.0015	0.0217	0.0538
Echinococcus multilocularis	Sugar transporter ERD6 protein	0.0015	0.0217	0.0894
Leishmania major	myo-inositol/proton symporter (MIT)	0.0015	0.0217	0.303
Loa Loa (eye worm)	CAMK/CAMK2 protein kinase	0.0033	0.0611	0.1593
Toxoplasma gondii	cell-cycle-associated protein kinase MAPK, putative	0.0174	0.3734	0.5643
Mycobacterium ulcerans	cytochrome P450 105Q4 Cyp105Q4	0.0007	0.0043	0.1038
Mycobacterium leprae	Probable prolyl tRNA synthetase ProS	0.0032	0.0597	1
Mycobacterium ulcerans	cytochrome P450 136A2 Cyp136A2	0.0007	0.0043	0.1038
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0217	0.0594
Trichomonas vaginalis	conserved hypothetical protein	0.0108	0.2266	0.6206
Mycobacterium tuberculosis	Probable cytochrome P450 144 Cyp144	0.0007	0.0043	0.1288
Loa Loa (eye worm)	sugar transporter	0.0108	0.2266	0.6014
Giardia lamblia	Sugar-proton symporter	0.0015	0.0217	0.346
Leishmania major	cytochrome p450-like protein	0.0007	0.0043	0.06
Mycobacterium tuberculosis	Probable cytochrome P450 130 Cyp130	0.0007	0.0043	0.1288
Trypanosoma brucei	Lanosterol 14-alpha demethylase	0.0007	0.0043	0.06
Toxoplasma gondii	lysine-tRNA ligase	0.0024	0.0414	0.0625
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0217	0.0594
Trypanosoma brucei	glucose transporter, putative	0.0033	0.0621	0.868
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0597	0.1553
Plasmodium falciparum	lysine--tRNA ligase	0.0024	0.0414	0.0399
Mycobacterium ulcerans	integral membrane transport protein	0.0015	0.0217	0.5239
Schistosoma mansoni	cytochrome P450	0.0007	0.0043	0.0121
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0217	0.0594
Brugia malayi	Major Facilitator Superfamily protein	0.0015	0.0217	0.0538

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 763449