Detailed information for compound 78014

Basic information

Technical information
  • TDR Targets ID: 78014
  • Name: 4-chloro-N-ethyl-3-nitro-N-propan-2-ylbenzene sulfonamide
  • MW: 306.766 | Formula: C11H15ClN2O4S
  • H donors: 0 H acceptors: 4 LogP: 2.69 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCN(S(=O)(=O)c1ccc(c(c1)[N+](=O)[O-])Cl)C(C)C
  • InChi: 1S/C11H15ClN2O4S/c1-4-13(8(2)3)19(17,18)9-5-6-10(12)11(7-9)14(15)16/h5-8H,4H2,1-3H3
  • InChiKey: PFCZOJVSEVCLSM-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 4-chloro-N-ethyl-N-isopropyl-3-nitro-benzenesulfonamide
  • 4-chloro-N-ethyl-N-isopropyl-3-nitrobenzenesulfonamide
  • 4-chloro-N-ethyl-3-nitro-N-propan-2-yl-benzenesulfonamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens vascular cell adhesion molecule 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0779 0.4303
Echinococcus multilocularis lipoxygenase domain containing protein 0.0021 0.0287 0.0278
Echinococcus granulosus neuropeptide receptor 0.0012 0.0057 0.0048
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0037 0.0681 0.0673
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0059 0.1253 0.1245
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0012 0.0057 0.0048
Loa Loa (eye worm) hypothetical protein 0.0012 0.0057 0.0082
Echinococcus multilocularis Immunoglobulin 0.0011 0.0036 0.0027
Schistosoma mansoni DNA polymerase eta 0.0014 0.0113 0.0104
Echinococcus granulosus neuropeptide FF receptor 2 0.0012 0.0057 0.0048
Echinococcus granulosus neuropeptides capa receptor 0.0012 0.0057 0.0048
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0011 0.0038 0.0291
Echinococcus multilocularis bloom syndrome protein 0.0022 0.0314 0.0306
Schistosoma mansoni vesicular amine transporter 0.0011 0.0036 0.0027
Treponema pallidum ATP-dependent RNA helicase 0.0024 0.0362 1
Onchocerca volvulus 0.0012 0.0057 0.0152
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0779 0.4303
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0022 0.0314 0.5303
Schistosoma mansoni amine GPCR 0.0012 0.0057 0.0048
Loa Loa (eye worm) hypothetical protein 0.0039 0.0744 0.1254
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.1276 0.1269
Trichomonas vaginalis conserved hypothetical protein 0.0061 0.1303 1
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0214 0.0205
Schistosoma mansoni biogenic amine receptor 0.0012 0.0057 0.0048
Brugia malayi steroid hormone receptor 0.0022 0.0298 0.0493
Echinococcus granulosus orexin receptor type 2 0.0012 0.0057 0.0048
Brugia malayi hypothetical protein 0.0012 0.0057 0.0082
Giardia lamblia Translation initiation factor eIF-4A, putative 0.0024 0.0362 0.1357
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.004 0.0053
Mycobacterium tuberculosis Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog) 0.0024 0.0362 1
Schistosoma mansoni hypothetical protein 0.0012 0.0057 0.0048
Schistosoma mansoni jun-related protein 0.014 0.3324 0.3318
Schistosoma mansoni polycystin 1-related 0.0021 0.0287 0.0278
Loa Loa (eye worm) hypothetical protein 0.0012 0.0057 0.0082
Loa Loa (eye worm) hypothetical protein 0.0011 0.004 0.0053
Echinococcus granulosus defective proboscis extension response 0.0011 0.0036 0.0027
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0022 0.0298 0.0493
Echinococcus granulosus Immunoglobulin 0.0011 0.0036 0.0027
Schistosoma mansoni hypothetical protein 0.014 0.3324 0.3318
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0015 0.0129 0.0121
Echinococcus multilocularis g protein coupled receptor 0.0012 0.0057 0.0048
Echinococcus granulosus roundabout 2 0.0018 0.0202 0.0194
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0165 0.0913
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0024 0.0362 0.1357
Loa Loa (eye worm) hypothetical protein 0.0012 0.0057 0.0082
Onchocerca volvulus Bile acid receptor homolog 0.0022 0.0298 0.0907
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0022 0.0298 0.029
Brugia malayi Serotonin receptor 0.0012 0.0057 0.0082
Loa Loa (eye worm) hypothetical protein 0.0011 0.0036 0.0047
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0012 0.0057 0.0048
Schistosoma mansoni histamine h1 receptor 0.0012 0.0057 0.0048
Echinococcus multilocularis Immunoglobulin 0.0011 0.0036 0.0027
Schistosoma mansoni phosphoglucomutase 0.0022 0.0299 0.0291
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0214 0.4971
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0022 0.0298 0.0493
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0012 0.0057 0.0048
Loa Loa (eye worm) hypothetical protein 0.0012 0.0057 0.0082
Echinococcus granulosus 7TM GPCR rhodopsin 0.0012 0.0057 0.0048
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0022 0.0298 0.029
Schistosoma mansoni hypothetical protein 0.0173 0.4142 0.4137
Echinococcus multilocularis G-protein coupled receptor, putative 0.0012 0.0057 0.0048
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0779 0.4303
Schistosoma mansoni nuclear hormone receptor 0.0022 0.0298 0.029
Echinococcus granulosus eukaryotic initiation factor 4A III 0.0024 0.0362 0.0353
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0012 0.0043 0.0034
Schistosoma mansoni hypothetical protein 0.0173 0.4142 0.4137
Brugia malayi ORL1-like opioid receptor 0.0012 0.0057 0.0082
Loa Loa (eye worm) hypothetical protein 0.0011 0.0036 0.0047
Loa Loa (eye worm) hypothetical protein 0.0012 0.0057 0.0082
Onchocerca volvulus 0.0012 0.0057 0.0152
Onchocerca volvulus 0.0012 0.0057 0.0152
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0403 1
Echinococcus granulosus lipoxygenase domain containing protein 0.0021 0.0287 0.0278
Echinococcus multilocularis rhodopsin orphan GPCR 0.0012 0.0057 0.0048
Schistosoma mansoni cpg binding protein 0.0032 0.056 0.0552
Brugia malayi Doublecortin family protein 0.0021 0.0287 0.0474
Giardia lamblia Rrm3p helicase 0.0061 0.1303 1
Echinococcus multilocularis g protein coupled receptor 0.0012 0.0057 0.0048
Loa Loa (eye worm) melatonin receptor type 1A 0.0012 0.0057 0.0082
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0025 0.0375 0.0367
Brugia malayi ecdysteroid receptor 0.0022 0.0298 0.0493
Schistosoma mansoni hypothetical protein 0.0012 0.0057 0.0048
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0403 0.2889
Trypanosoma brucei retrotransposon hot spot protein 4 (RHS4), interrupted 0.0023 0.0346 0.1911
Loa Loa (eye worm) hypothetical protein 0.0021 0.0287 0.0474
Echinococcus multilocularis serotonin receptor 0.0012 0.0057 0.0048
Loa Loa (eye worm) bromodomain containing protein 0.0018 0.0208 0.0339
Schistosoma mansoni hypothetical protein 0.0012 0.0043 0.0034
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0012 0.0057 0.0048
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0012 0.0057 0.0082
Onchocerca volvulus 0.0012 0.0057 0.0152
Trypanosoma brucei DNA polymerase kappa, putative 0.0031 0.0529 0.2921
Loa Loa (eye worm) hypothetical protein 0.0011 0.0036 0.0047
Loa Loa (eye worm) neuropeptide F receptor 0.0012 0.0057 0.0082
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0022 0.0314 0.0306
Echinococcus multilocularis neuropeptide receptor A26 0.0012 0.0057 0.0048
Echinococcus granulosus allatostatin A receptor 0.0012 0.0057 0.0048
Loa Loa (eye worm) hypothetical protein 0.0011 0.0038 0.0049
Onchocerca volvulus 0.0012 0.0057 0.0152
Wolbachia endosymbiont of Brugia malayi ribonuclease HI 0.0022 0.0299 1
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0022 0.0298 0.029
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0012 0.0057 0.0048
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0022 0.0314 0.1736
Loa Loa (eye worm) hypothetical protein 0.0012 0.0057 0.0082
Trypanosoma cruzi Eukaryotic initiation factor 4A-1 0.0024 0.0362 0.256
Schistosoma mansoni amine GPCR 0.0012 0.0057 0.0048
Brugia malayi hypothetical protein 0.0012 0.0057 0.0082
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0022 0.0298 0.0493
Loa Loa (eye worm) hypothetical protein 0.0072 0.1583 0.2682
Echinococcus granulosus RUN 0.0021 0.0287 0.0278
Schistosoma mansoni thyroid hormone receptor 0.0022 0.0298 0.029
Loa Loa (eye worm) hypothetical protein 0.0018 0.0202 0.033
Echinococcus granulosus somatostatin receptor 0.0012 0.0057 0.0048
Echinococcus multilocularis survival motor neuron protein 1 0.0241 0.5879 0.5876
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0165 0.0913
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0022 0.0298 0.0493
Loa Loa (eye worm) hypothetical protein 0.0012 0.0057 0.0082
Echinococcus granulosus ribonuclease H1 0.0022 0.0299 0.0291
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0403 0.2227
Schistosoma mansoni hypothetical protein 0.0012 0.0057 0.0048
Brugia malayi Bromodomain containing protein 0.0039 0.0743 0.125
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0022 0.0298 0.029
Trypanosoma brucei ingi protein (ORF1) 0.0023 0.0346 0.1911
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0011 0.0036 0.0027
Brugia malayi RNase H family protein 0.0022 0.0299 0.0495
Schistosoma mansoni survival motor neuron protein 0.0049 0.1 0.0992
Onchocerca volvulus 0.0012 0.0057 0.0152
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0022 0.0298 0.0493
Schistosoma mansoni neuropeptide receptor 0.0012 0.0057 0.0048
Schistosoma mansoni lipoxygenase 0.0059 0.1253 0.1245
Loa Loa (eye worm) hypothetical protein 0.0168 0.4028 0.6846
Brugia malayi hypothetical protein 0.0241 0.5879 1
Brugia malayi Bloom's syndrome protein homolog 0.0022 0.0314 0.0521
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0012 0.0057 0.0048
Schistosoma mansoni neuropeptide F-like receptor 0.0012 0.0057 0.0048
Loa Loa (eye worm) hypothetical protein 0.0022 0.0298 0.0493
Trichomonas vaginalis DNA polymerase eta, putative 0.004 0.0779 0.5187
Echinococcus granulosus hypothetical protein 0.0012 0.0057 0.0048
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0012 0.0057 0.0048
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0403 0.328
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0012 0.0057 0.0082
Trypanosoma brucei RNA helicase, putative 0.0081 0.181 1
Onchocerca volvulus Neuropeptide F receptor homolog 0.0012 0.0057 0.0152
Schistosoma mansoni hypothetical protein 0.0021 0.0287 0.0278
Echinococcus granulosus lipoxygenase domain containing protein 0.0021 0.0287 0.0278
Trypanosoma brucei Eukaryotic initiation factor 4A-1 0.0024 0.0362 0.1997
Loa Loa (eye worm) hypothetical protein 0.0241 0.5879 1
Brugia malayi hypothetical protein 0.0011 0.004 0.0053
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0011 0.0038 0.0095
Loa Loa (eye worm) hypothetical protein 0.0012 0.0057 0.0082
Echinococcus granulosus tm gpcr rhodopsin 0.0012 0.0057 0.0048
Echinococcus multilocularis rhodopsin orphan GPCR 0.0012 0.0057 0.0048
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0012 0.0057 0.0048
Echinococcus multilocularis neuropeptides capa receptor 0.0012 0.0057 0.0048
Echinococcus granulosus G protein coupled receptor 139 0.0012 0.0057 0.0048
Brugia malayi Fibronectin type III domain containing protein 0.0011 0.0036 0.0047
Schistosoma mansoni hypothetical protein 0.0012 0.0057 0.0048
Schistosoma mansoni zinc finger protein 0.0022 0.0298 0.029
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0014 0.0113 0.0104
Trypanosoma cruzi DNA repair and recombination helicase protein PIF7, putative 0.0061 0.1303 1
Schistosoma mansoni neuropeptide receptor 0.0012 0.0057 0.0048
Loa Loa (eye worm) hypothetical protein 0.0012 0.0057 0.0082
Loa Loa (eye worm) hypothetical protein 0.0012 0.0057 0.0082
Echinococcus granulosus histone lysine methyltransferase setb 0.0018 0.0208 0.0199
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0012 0.0057 0.0048
Echinococcus granulosus FTZ F1 alpha 0.0022 0.0298 0.029
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.0298 0.0493
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0012 0.0057 0.0048
Trypanosoma brucei DNA polymerase kappa, putative 0.0031 0.0529 0.2921
Schistosoma mansoni zinc finger protein 0.0016 0.0146 0.0138
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0062 0.1338 0.1331
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0214 0.085
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0022 0.0298 0.029
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0403 0.2889
Loa Loa (eye worm) hypothetical protein 0.0012 0.0057 0.0082
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0012 0.0057 0.0048
Echinococcus granulosus rhodopsin orphan GPCR 0.0012 0.0057 0.0048
Brugia malayi Melatonin receptor type 1A 0.0012 0.0057 0.0082
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0012 0.0057 0.0082
Leishmania major PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative 0.0061 0.1303 1
Echinococcus granulosus neuropeptide s receptor 0.0012 0.0057 0.0048
Brugia malayi hypothetical protein 0.0012 0.0057 0.0082
Echinococcus multilocularis g protein coupled receptor 0.0012 0.0057 0.0048
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0021 0.0278 0.6638
Trypanosoma brucei ingi protein (ORF1) 0.0023 0.0346 0.1911
Loa Loa (eye worm) hypothetical protein 0.0012 0.0057 0.0082
Echinococcus multilocularis zinc finger protein 0.0022 0.0298 0.029
Brugia malayi nuclear hormone receptor 0.0022 0.0298 0.0493
Brugia malayi Tachykinin-like peptides receptor 99D 0.0012 0.0057 0.0082
Brugia malayi polk-prov protein 0.0031 0.0529 0.0886
Echinococcus multilocularis rhodopsin orphan GPCR 0.0012 0.0057 0.0048
Loa Loa (eye worm) hypothetical protein 0.0011 0.0036 0.0047
Brugia malayi CXXC zinc finger family protein 0.0028 0.047 0.0785
Schistosoma mansoni hypothetical protein 0.0061 0.1303 0.1296
Brugia malayi hypothetical protein 0.0012 0.0057 0.0082
Echinococcus multilocularis jun protein 0.0173 0.4148 0.4143
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0022 0.0298 0.0493
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0012 0.0057 0.0048
Loa Loa (eye worm) hypothetical protein 0.0012 0.0057 0.0082
Loa Loa (eye worm) hypothetical protein 0.0022 0.0298 0.0493
Schistosoma mansoni hypothetical protein 0.0049 0.1 0.0992
Loa Loa (eye worm) hypothetical protein 0.0012 0.0057 0.0082
Trichomonas vaginalis DNA helicase recq, putative 0.0022 0.0314 0.0922
Loa Loa (eye worm) hypothetical protein 0.0012 0.0057 0.0082
Echinococcus granulosus geminin 0.0173 0.4142 0.4137
Echinococcus multilocularis neuropeptide receptor 0.0012 0.0057 0.0048
Loa Loa (eye worm) hypothetical protein 0.0022 0.0298 0.0493
Trypanosoma brucei DNA polymerase IV, putative 0.004 0.0779 0.4303
Loa Loa (eye worm) hypothetical protein 0.0012 0.0057 0.0082
Schistosoma mansoni biogenic amine (5HT) receptor 0.0012 0.0057 0.0048
Loa Loa (eye worm) hypothetical protein 0.0012 0.0057 0.0082
Echinococcus granulosus peptide allatostatin:somatostatin 0.0012 0.0057 0.0048
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0022 0.0314 0.0306
Schistosoma mansoni lipoxygenase 0.0021 0.0287 0.0278
Schistosoma mansoni blooms syndrome DNA helicase 0.0011 0.0027 0.0018
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0014 0.0113 0.0104
Echinococcus granulosus rhodopsin orphan GPCR 0.0012 0.0057 0.0048
Trypanosoma brucei DNA polymerase IV, putative 0.004 0.0779 0.4303
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0011 0.004 0.0031
Echinococcus multilocularis fmrfamide receptor 0.0012 0.0057 0.0048
Schistosoma mansoni phosphoglucomutase 0.0022 0.0299 0.0291
Loa Loa (eye worm) hypothetical protein 0.0012 0.0057 0.0082
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0022 0.0298 0.029
Loa Loa (eye worm) doublecortin family protein 0.0021 0.0287 0.0474
Echinococcus multilocularis rhodopsin orphan GPCR 0.0012 0.0057 0.0048
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0022 0.0298 0.0493
Schistosoma mansoni biogenic amine (5HT) receptor 0.0012 0.0057 0.0048
Brugia malayi hypothetical protein 0.0012 0.0057 0.0082
Echinococcus multilocularis rhodopsin orphan GPCR 0.0012 0.0057 0.0048
Brugia malayi Immunoglobulin I-set domain containing protein 0.0011 0.0036 0.0047
Loa Loa (eye worm) hypothetical protein 0.0012 0.0057 0.0082
Loa Loa (eye worm) hypothetical protein 0.0022 0.0314 0.0521
Loa Loa (eye worm) RecQ helicase 0.0022 0.0314 0.0521
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0022 0.0298 0.0493
Loa Loa (eye worm) hypothetical protein 0.0018 0.0202 0.033
Echinococcus granulosus survival motor neuron protein 1 0.0241 0.5879 0.5876
Onchocerca volvulus 0.0021 0.0287 0.087
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0022 0.0314 0.0521
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0022 0.0298 0.0493
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0022 0.0298 0.0493
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0012 0.0057 0.0048
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.047 0.0785
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0192 0.0184
Schistosoma mansoni biogenic amine receptor 0.0012 0.0057 0.0048
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0012 0.0057 0.0048
Loa Loa (eye worm) hypothetical protein 0.0012 0.0057 0.0082
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0165 0.0913
Echinococcus multilocularis roundabout 2 0.0018 0.0202 0.0194
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0012 0.0057 0.0048
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0012 0.0057 0.0048
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0022 0.0298 0.0493
Echinococcus granulosus g protein coupled receptor 0.0012 0.0057 0.0048
Onchocerca volvulus 0.0012 0.0057 0.0152
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0779 0.4303
Echinococcus multilocularis neuropeptide Y receptor 0.0012 0.0057 0.0048
Brugia malayi AKH receptor 0.0012 0.0057 0.0082
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0012 0.0057 0.0082
Echinococcus multilocularis FTZ F1 alpha 0.0022 0.0298 0.029
Brugia malayi Dopamine receptor protein 2 0.0012 0.0057 0.0082
Trichomonas vaginalis ribonuclease H1, putative 0.0022 0.0299 0.0785
Brugia malayi RNase H family protein 0.0022 0.0299 0.0495
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0022 0.0314 0.0306
Echinococcus multilocularis G protein coupled receptor 139 0.0012 0.0057 0.0048
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0022 0.0314 0.2186
Trypanosoma brucei unspecified product 0.0023 0.0346 0.1911
Giardia lamblia Ribonuclease H 0.0022 0.0299 0.0785
Echinococcus granulosus rhodopsin orphan GPCR 0.0012 0.0057 0.0048
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0779 0.5857
Loa Loa (eye worm) hypothetical protein 0.0021 0.0287 0.0474
Schistosoma mansoni cpg binding protein 0.0028 0.047 0.0461
Leishmania major PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative 0.0061 0.1303 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0113 0.0177
Echinococcus granulosus zinc finger protein 0.0022 0.0298 0.029
Schistosoma mansoni opsin-like receptor 0.0012 0.0057 0.0048
Loa Loa (eye worm) hypothetical protein 0.0011 0.004 0.0053
Loa Loa (eye worm) PHD-finger family protein 0.0021 0.0285 0.047
Echinococcus granulosus rhodopsin orphan GPCR 0.0012 0.0057 0.0048
Plasmodium falciparum LCCL domain-containing protein 0.0021 0.0287 0.3846
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0022 0.0298 0.029
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0012 0.0057 0.0048
Entamoeba histolytica deoxycytidyl transferase, putative 0.0014 0.0113 0.0673
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0021 0.0278 0.1388
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0214 0.1181
Brugia malayi nuclear receptor NHR-88 0.0022 0.0298 0.0493
Onchocerca volvulus 0.0012 0.0057 0.0152
Onchocerca volvulus 0.0012 0.0057 0.0152
Schistosoma mansoni biogenic amine receptor 0.0012 0.0057 0.0048
Schistosoma mansoni ap endonuclease 0.0018 0.0214 0.0205
Echinococcus granulosus tachykinin peptides receptor 99D 0.0012 0.0057 0.0048
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0022 0.0314 0.0521
Brugia malayi hypothetical protein 0.0021 0.0287 0.0474
Loa Loa (eye worm) transcription factor SMAD2 0.0122 0.2844 0.4831
Loa Loa (eye worm) hypothetical protein 0.0011 0.004 0.0053
Onchocerca volvulus 0.0012 0.0057 0.0152
Echinococcus granulosus dna polymerase eta 0.0014 0.0113 0.0104
Brugia malayi Serotonin receptor 0.0012 0.0057 0.0082
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.004 0.0779 0.5187
Schistosoma mansoni amine GPCR 0.0012 0.0057 0.0048
Schistosoma mansoni myosin xvIII 0.0012 0.0057 0.0048
Echinococcus multilocularis rhodopsin orphan GPCR 0.0012 0.0057 0.0048
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0022 0.0314 0.1693
Brugia malayi nuclear receptor RXR 0.0011 0.004 0.0053
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0011 0.004 0.0031
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0022 0.0298 0.029
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0018 0.0208 0.0199
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0011 0.0028 0.001
Echinococcus granulosus jun protein 0.0173 0.4148 0.4143
Brugia malayi G protein-coupled receptor 0.0012 0.0057 0.0082
Plasmodium vivax RNA helicase-1, putative 0.0024 0.0362 0.8896
Brugia malayi hypothetical protein 0.0011 0.004 0.0053
Trypanosoma brucei ribonuclease H1 0.0022 0.0299 0.1653
Entamoeba histolytica recQ family DNA helicase 0.0011 0.0038 0.0086
Loa Loa (eye worm) hypothetical protein 0.0012 0.0057 0.0082
Trypanosoma cruzi ribonuclease H1, putative 0.0022 0.0299 0.2068
Loa Loa (eye worm) hypothetical protein 0.0012 0.0057 0.0082
Loa Loa (eye worm) hypothetical protein 0.0022 0.0298 0.0493
Trypanosoma cruzi DNA repair and recombination helicase protein PIF6, putative 0.0061 0.1303 1
Echinococcus multilocularis ribonuclease H1 0.0022 0.0299 0.0291
Trypanosoma cruzi DNA repair and recombination helicase protein PIF7, putative 0.0061 0.1303 1
Echinococcus multilocularis cpg binding protein 0.0032 0.056 0.0552
Brugia malayi putative neuropeptide receptor NPR1 0.0012 0.0057 0.0082
Brugia malayi GnHR receptor homolog 0.0012 0.0057 0.0082
Loa Loa (eye worm) hypothetical protein 0.0022 0.0298 0.0493
Echinococcus granulosus ecdysone induced protein 78C 0.0022 0.0298 0.029
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0059 0.1253 0.1245
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0012 0.0057 0.0152
Loa Loa (eye worm) hypothetical protein 0.0012 0.0057 0.0082
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0011 0.004 0.0053
Loa Loa (eye worm) hypothetical protein 0.0012 0.0057 0.0082
Schistosoma mansoni terminal deoxycytidyl transferase 0.0014 0.0113 0.0104
Onchocerca volvulus 0.0021 0.0287 0.087
Leishmania major hypothetical protein, conserved 0.0016 0.0146 0.0284
Schistosoma mansoni amine GPCR 0.0012 0.0057 0.0048
Loa Loa (eye worm) hypothetical protein 0.0011 0.0038 0.0049
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0779 0.5857
Echinococcus granulosus biogenic amine 5HT receptor 0.0012 0.0057 0.0048
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0018 0.0214 0.1466
Loa Loa (eye worm) hypothetical protein 0.0012 0.0057 0.0082
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0022 0.0298 0.0493
Echinococcus multilocularis neuropeptides capa receptor 0.0012 0.0057 0.0048
Onchocerca volvulus 0.0028 0.047 0.1443
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0014 0.0113 0.0104
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0012 0.0057 0.0048
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0018 0.0208 0.0199
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0024 0.0362 0.1357
Loa Loa (eye worm) hypothetical protein 0.0012 0.0057 0.0082
Brugia malayi hypothetical protein 0.0017 0.0172 0.0278
Brugia malayi Bromodomain containing protein 0.0078 0.1735 0.2941
Trypanosoma brucei hypothetical protein, conserved 0.0023 0.0346 0.1911
Leishmania major eukaryotic initiation factor 4a, putative 0.0024 0.0362 0.2091
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0192 0.0184
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0012 0.0057 0.0048
Trypanosoma brucei ISWI complex protein 0.0016 0.0146 0.0809
Trypanosoma cruzi ISWI complex protein 0.0016 0.0146 0.086
Schistosoma mansoni ap endonuclease 0.0018 0.0214 0.0205
Echinococcus granulosus tm gpcr rhodopsin 0.0012 0.0057 0.0048
Schistosoma mansoni steroid hormone receptor ad4bp 0.0022 0.0298 0.029
Echinococcus multilocularis muscleblind protein 1 0.0152 0.3622 0.3616
Loa Loa (eye worm) hypothetical protein 0.0012 0.0057 0.0082
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0022 0.0314 0.2506
Loa Loa (eye worm) hypothetical protein 0.0011 0.0036 0.0047
Loa Loa (eye worm) hypothetical protein 0.0011 0.0036 0.0047
Loa Loa (eye worm) hypothetical protein 0.0011 0.004 0.0053
Onchocerca volvulus 0.0012 0.0057 0.0152
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0779 0.5857
Schistosoma mansoni nephrin 0.0014 0.0109 0.01
Schistosoma mansoni opsin-like receptor 0.0012 0.0057 0.0048
Brugia malayi PHD-finger family protein 0.0027 0.0437 0.0729
Echinococcus granulosus g protein coupled receptor 0.0012 0.0057 0.0048
Loa Loa (eye worm) hypothetical protein 0.0012 0.0057 0.0082
Echinococcus multilocularis ecdysone induced protein 78C 0.0022 0.0298 0.029
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0024 0.0362 0.1357
Loa Loa (eye worm) hypothetical protein 0.0012 0.0057 0.0082
Schistosoma mansoni cell adhesion molecule 0.0015 0.0129 0.0121
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0012 0.0057 0.0048
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0012 0.0057 0.0048
Schistosoma mansoni loxhd1 0.0021 0.0287 0.0278
Echinococcus granulosus rhodopsin orphan GPCR 0.0012 0.0057 0.0048
Schistosoma mansoni coup transcription factor 0.0022 0.0298 0.029
Schistosoma mansoni neuropeptide receptor 0.0012 0.0057 0.0048
Brugia malayi hypothetical protein 0.0011 0.0036 0.0047
Plasmodium vivax multidomain scavenger receptor, putative 0.0021 0.0287 0.6905
Onchocerca volvulus Protein ultraspiracle homolog 0.0022 0.0298 0.0907
Echinococcus multilocularis neuropeptide s receptor 0.0012 0.0057 0.0048
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0214 0.1392
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0278 0.1535
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0012 0.0057 0.0048
Loa Loa (eye worm) G-protein coupled receptor 0.0012 0.0057 0.0082
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0012 0.0057 0.0048
Schistosoma mansoni rab6-interacting 0.0021 0.0287 0.0278
Echinococcus granulosus neuroglian 0.0014 0.0109 0.01
Echinococcus multilocularis thyroid hormone receptor alpha 0.0022 0.0298 0.029
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0779 0.4303
Onchocerca volvulus 0.0049 0.1 0.3103
Echinococcus multilocularis dro:myosuppressin receptor 0.0012 0.0057 0.0048
Echinococcus granulosus biogenic amine 5HT receptor 0.0012 0.0057 0.0048
Entamoeba histolytica DEAD/DEAH box helicase, putative 0.0024 0.0362 0.2624
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0014 0.0113 0.0177
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0015 0.0129 0.0205
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0012 0.0057 0.0048
Brugia malayi hypothetical protein 0.0012 0.0057 0.0082
Onchocerca volvulus 0.0012 0.0057 0.0152
Loa Loa (eye worm) hypothetical protein 0.0012 0.0057 0.0082
Schistosoma mansoni cpg binding protein 0.0032 0.056 0.0552
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0779 0.4303
Schistosoma mansoni DNA helicase recq5 0.0022 0.0314 0.0306
Echinococcus granulosus fetal alzheimer antigen falz 0.0025 0.0375 0.0367
Trypanosoma brucei unspecified product 0.0034 0.0614 0.3389
Trypanosoma cruzi ISWI complex protein 0.0016 0.0146 0.086
Echinococcus multilocularis dna polymerase kappa 0.004 0.0779 0.0771
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0022 0.0298 0.029
Brugia malayi Immunoglobulin I-set domain containing protein 0.0015 0.0129 0.0205
Schistosoma mansoni DNA helicase recq1 0.0022 0.0314 0.0306
Echinococcus granulosus 7tm_1 domain containing protein 0.0012 0.0057 0.0048
Brugia malayi neuropeptide F receptor 0.0012 0.0057 0.0082
Schistosoma mansoni neuropeptide F-like receptor 0.0012 0.0057 0.0048
Brugia malayi MH2 domain containing protein 0.0122 0.2844 0.4831
Schistosoma mansoni DEAD box ATP-dependent RNA helicase 0.0024 0.0362 0.0353
Brugia malayi hypothetical protein 0.0012 0.0057 0.0082
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0062 0.1338 0.1331
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0012 0.0057 0.0048
Brugia malayi G-protein coupled receptor 0.0012 0.0057 0.0082
Loa Loa (eye worm) hypothetical protein 0.0031 0.0529 0.0886
Brugia malayi Steroid receptor seven-up type 2 0.0022 0.0298 0.0493
Echinococcus granulosus alpha 1A adrenergic receptor 0.0012 0.0057 0.0048
Loa Loa (eye worm) hypothetical protein 0.0012 0.0057 0.0082
Loa Loa (eye worm) MH2 domain-containing protein 0.0122 0.2844 0.4831
Toxoplasma gondii ribonuclease HI protein 0.0022 0.0299 0.2376
Schistosoma mansoni growth hormone secretagogue receptor 0.0012 0.0057 0.0048
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0022 0.0298 0.0493
Trypanosoma cruzi Eukaryotic initiation factor 4A-1 0.0024 0.0362 0.256
Entamoeba histolytica recQ family helicase, putative 0.0022 0.0314 0.2253
Schistosoma mansoni thyroid hormone receptor 0.0022 0.0298 0.029
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0779 0.4303
Echinococcus granulosus dna polymerase kappa 0.004 0.0779 0.0771
Loa Loa (eye worm) hypothetical protein 0.0012 0.0057 0.0082
Trypanosoma brucei DNA polymerase IV, putative 0.0034 0.0614 0.3389
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0037 0.0681 0.0673
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0012 0.0057 0.0048
Loa Loa (eye worm) hypothetical protein 0.0018 0.0208 0.0339
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0022 0.0298 0.029
Echinococcus multilocularis muscleblind protein 0.0152 0.3622 0.3616
Giardia lamblia DINP protein human, muc B family 0.0021 0.0278 0.0588
Brugia malayi G protein-coupled receptor F59B2.13 0.0012 0.0057 0.0082
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0214 0.0205
Echinococcus granulosus fmrfamide receptor 0.0012 0.0057 0.0048
Loa Loa (eye worm) hypothetical protein 0.0012 0.0057 0.0082
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0022 0.0298 0.0493
Schistosoma mansoni DEAD box ATP-dependent RNA helicase 0.0024 0.0362 0.0353
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0022 0.0298 0.029
Echinococcus multilocularis RUN 0.0021 0.0287 0.0278
Echinococcus granulosus Polycystic kidney disease protein 0.0021 0.0287 0.0278
Schistosoma mansoni neuropeptide receptor 0.0012 0.0057 0.0048
Trypanosoma cruzi DNA polymerase eta, putative 0.0014 0.0113 0.0593
Loa Loa (eye worm) TYRA-2 protein 0.0012 0.0057 0.0082
Echinococcus multilocularis rhodopsin orphan GPCR 0.0012 0.0057 0.0048
Schistosoma mansoni neuropeptide f receptor 76f 0.0012 0.0057 0.0048
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0011 0.0036 0.0027
Leishmania major ribonuclease H1, putative 0.0022 0.0299 0.1568
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0022 0.0298 0.029
Brugia malayi RE15519p 0.0012 0.0057 0.0082
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0011 0.0036 0.0027
Echinococcus multilocularis neuropeptide FF receptor 2 0.0012 0.0057 0.0048
Echinococcus granulosus g protein coupled receptor 0.0012 0.0057 0.0048
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0012 0.0057 0.0048
Onchocerca volvulus 0.0022 0.0298 0.0907
Echinococcus granulosus rhodopsin orphan GPCR 0.0012 0.0057 0.0048
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0018 0.0208 0.0199
Echinococcus granulosus ATP dependent DNA helicase PIF1 0.0061 0.1303 0.1296
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0011 0.004 0.0031
Trypanosoma cruzi ribonuclease H1, putative 0.0022 0.0299 0.2068
Mycobacterium ulcerans DNA polymerase IV 0.004 0.0779 1
Brugia malayi G-protein coupled receptor 0.0012 0.0057 0.0082
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0012 0.0057 0.0082
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0022 0.0314 0.5303
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0022 0.0298 0.0907
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.0192 0.0184
Echinococcus multilocularis orexin receptor type 2 0.0012 0.0057 0.0048
Brugia malayi hypothetical protein 0.0012 0.0057 0.0082
Brugia malayi Dopamine receptor 0.0012 0.0057 0.0082
Loa Loa (eye worm) hypothetical protein 0.0152 0.3622 0.6155
Loa Loa (eye worm) hypothetical protein 0.0012 0.0057 0.0082
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0012 0.0057 0.0082
Loa Loa (eye worm) neuropeptide F receptor 0.0012 0.0057 0.0082
Echinococcus granulosus neuropeptide receptor 0.0012 0.0057 0.0048
Loa Loa (eye worm) hypothetical protein 0.0012 0.0057 0.0082
Echinococcus granulosus neuropeptides capa receptor 0.0012 0.0057 0.0048
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0012 0.0057 0.0048
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0214 0.1392
Brugia malayi hypothetical protein 0.0021 0.0287 0.0474
Schistosoma mansoni amine GPCR 0.0012 0.0057 0.0048
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0022 0.0314 0.2506
Brugia malayi F/Y-rich N-terminus family protein 0.0011 0.0019 0.0018
Echinococcus multilocularis serotonin receptor 0.0012 0.0057 0.0048
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0049 0.1 0.1689
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0012 0.0057 0.0048
Echinococcus granulosus serotonin receptor 0.0012 0.0057 0.0048
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0022 0.0298 0.0493
Onchocerca volvulus 0.0136 0.3204 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0057 0.0082
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.004 0.0031
Echinococcus granulosus twitchin 0.0014 0.0109 0.01
Loa Loa (eye worm) hypothetical protein 0.0045 0.0896 0.1512
Echinococcus multilocularis eukaryotic initiation factor 4A 0.0024 0.0362 0.0353
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0022 0.0298 0.029
Schistosoma mansoni hypothetical protein 0.0081 0.181 0.1803
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0012 0.0057 0.0048
Schistosoma mansoni phosphoglucomutase 0.0022 0.0299 0.0291
Loa Loa (eye worm) hypothetical protein 0.0022 0.0298 0.0493
Leishmania major hypothetical protein, conserved 0.0026 0.0403 0.2441
Brugia malayi ImpB/MucB/SamB family protein 0.0014 0.0113 0.0177
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0012 0.0057 0.0048
Brugia malayi photoreceptor-specific nuclear receptor 0.0022 0.0298 0.0493
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0022 0.0298 0.0493
Echinococcus granulosus sex peptide receptor 0.0012 0.0057 0.0048
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0022 0.0298 0.0493
Onchocerca volvulus 0.0012 0.0057 0.0152
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0.0214 0.4064
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0012 0.0057 0.0048
Loa Loa (eye worm) hypothetical protein 0.0012 0.0057 0.0082
Onchocerca volvulus 0.0012 0.0057 0.0152
Echinococcus granulosus bloom syndrome protein 0.0022 0.0314 0.0306
Schistosoma mansoni alpha-1 adrenergic receptor 0.0012 0.0057 0.0048
Loa Loa (eye worm) hypothetical protein 0.0012 0.0057 0.0082
Brugia malayi hypothetical protein 0.0026 0.0403 0.0672
Mycobacterium ulcerans DNA polymerase IV 0.004 0.0779 1
Onchocerca volvulus 0.0012 0.0057 0.0152
Echinococcus multilocularis neuroglian 0.0014 0.0109 0.01
Treponema pallidum ribonuclease H (rnhA) 0.0022 0.0299 0.8078
Brugia malayi RNase H family protein 0.0022 0.0299 0.0495
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0022 0.0298 0.0493
Loa Loa (eye worm) steroid hormone receptor 0.0022 0.0298 0.0493
Echinococcus multilocularis g-protein coupled receptor 0.0012 0.0057 0.0048
Echinococcus granulosus g-protein coupled receptor 0.0012 0.0057 0.0048
Echinococcus multilocularis ATP dependent DNA helicase PIF1 0.0061 0.1303 0.1296
Echinococcus multilocularis allatostatin A receptor 0.0012 0.0057 0.0048
Echinococcus multilocularis dna polymerase eta 0.0014 0.0113 0.0104
Echinococcus granulosus tm gpcr rhodopsin 0.0012 0.0057 0.0048
Schistosoma mansoni adenoreceptor 0.0012 0.0057 0.0048
Loa Loa (eye worm) hypothetical protein 0.0012 0.0057 0.0082
Giardia lamblia Sgs1 DNA helicase, putative 0.0022 0.0314 0.0922
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0214 0.035
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0022 0.0298 0.029
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0022 0.0298 0.029
Echinococcus granulosus dro:myosuppressin receptor 0.0012 0.0057 0.0048
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0012 0.0043 0.0034
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0022 0.0298 0.029
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0214 0.035
Brugia malayi larval opioid receptor 0.0012 0.0057 0.0082
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0173 0.4148 0.4143
Brugia malayi hypothetical protein 0.0136 0.3204 0.5442
Echinococcus granulosus rhodopsin orphan GPCR 0.0012 0.0057 0.0048
Echinococcus multilocularis rhodopsin orphan GPCR 0.0012 0.0057 0.0048
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0012 0.0057 0.0048
Entamoeba histolytica hypothetical protein, conserved 0.0061 0.1303 1
Trichomonas vaginalis DNA helicase recq, putative 0.0022 0.0314 0.0922
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0025 0.0375 0.0367
Schistosoma mansoni hypothetical protein 0.0021 0.0285 0.0276
Schistosoma mansoni RAR-like nuclear receptor 0.0022 0.0298 0.029
Loa Loa (eye worm) G-protein coupled receptor 0.0012 0.0057 0.0082
Onchocerca volvulus Eukaryotic initiation factor 4A homolog 0.0024 0.0362 0.1105
Onchocerca volvulus Ribonuclease H1 homolog 0.0022 0.0299 0.091
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0012 0.0057 0.0048
Echinococcus multilocularis sex peptide receptor 0.0012 0.0057 0.0048
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0022 0.0298 0.0493
Echinococcus multilocularis fmrfamide receptor 0.0012 0.0057 0.0048
Loa Loa (eye worm) hypothetical protein 0.0152 0.3622 0.6155
Brugia malayi Muscleblind-like protein 0.0152 0.3622 0.6155
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0022 0.0314 0.0521
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0022 0.0298 0.029
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0779 0.4303
Toxoplasma gondii histone lysine methyltransferase SET1 0.0056 0.1175 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.004 0.0053
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0012 0.0057 0.0048
Brugia malayi follicle stimulating hormone receptor 0.0012 0.0057 0.0082
Brugia malayi putative neuropeptide receptor 0.0012 0.0057 0.0082
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0173 0.4148 0.4143
Schistosoma mansoni bromodomain containing protein 0.0066 0.1431 0.1424
Entamoeba histolytica DNA repair and recombination protein, putative 0.0061 0.1303 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0057 0.0082
Trichomonas vaginalis DNA helicase recq1, putative 0.0022 0.0314 0.0922
Loa Loa (eye worm) hypothetical protein 0.0012 0.0057 0.0082
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0779 0.4303
Echinococcus multilocularis neuropeptide receptor 0.0012 0.0057 0.0048
Loa Loa (eye worm) hypothetical protein 0.0012 0.0057 0.0082
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0012 0.0057 0.0048
Loa Loa (eye worm) hypothetical protein 0.0012 0.0057 0.0082
Echinococcus multilocularis geminin 0.0173 0.4142 0.4137
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0022 0.0298 0.029
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0012 0.0057 0.0048
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0012 0.0057 0.0048
Brugia malayi sulfakinin receptor protein 0.0012 0.0057 0.0082
Echinococcus multilocularis neuropeptide Y receptor 0.0012 0.0057 0.0048
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0012 0.0057 0.0048
Trypanosoma brucei DNA repair and recombination helicase protein PIF7 0.0061 0.1303 0.72
Brugia malayi hypothetical protein 0.0012 0.0057 0.0082
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0403 1
Echinococcus granulosus cpg binding protein 0.0032 0.056 0.0552
Loa Loa (eye worm) hypothetical protein 0.0026 0.0403 0.0672
Brugia malayi neuropeptide F receptor 0.0012 0.0057 0.0082
Echinococcus multilocularis eukaryotic initiation factor 4A III 0.0024 0.0362 0.0353
Schistosoma mansoni hypothetical protein 0.0403 1 1
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0022 0.0314 0.0306
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0022 0.0298 0.029
Onchocerca volvulus 0.0012 0.0057 0.0152
Echinococcus granulosus eukaryotic initiation factor 4A 0.0024 0.0362 0.0353
Loa Loa (eye worm) hypothetical protein 0.0024 0.0362 0.0601
Echinococcus granulosus neuropeptide Y receptor 0.0012 0.0057 0.0048
Schistosoma mansoni rab6-interacting 0.0021 0.0287 0.0278
Leishmania major eukaryotic initiation factor 4a, putative 0.0024 0.0362 0.2091
Trypanosoma brucei DNA polymerase eta, putative 0.0014 0.0113 0.0622
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0012 0.0057 0.0082
Schistosoma mansoni retinoic acid receptor RXR 0.0022 0.0298 0.029
Echinococcus granulosus neuropeptide Y receptor 0.0012 0.0057 0.0048
Brugia malayi ImpB/MucB/SamB family protein 0.0014 0.0113 0.0177
Echinococcus granulosus neuropeptide receptor A26 0.0012 0.0057 0.0048
Toxoplasma gondii eukaryotic initiation factor-4A, putative 0.0024 0.0362 0.2918
Schistosoma mansoni hypothetical protein 0.0016 0.0146 0.0138
Echinococcus granulosus muscleblind protein 0.0152 0.3622 0.3616
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0012 0.0057 0.0082
Treponema pallidum exodeoxyribonuclease (exoA) 0.0018 0.0214 0.5439
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0403 1
Echinococcus multilocularis somatostatin receptor 0.0012 0.0057 0.0048
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0779 0.5857
Loa Loa (eye worm) hypothetical protein 0.0012 0.0057 0.0082
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0012 0.0057 0.0048
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0012 0.0057 0.0048
Leishmania major DNA polymerase kappa, putative 0.0021 0.0278 0.1388
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0012 0.0057 0.0082
Onchocerca volvulus 0.0012 0.0057 0.0152
Toxoplasma gondii exonuclease III APE 0.0018 0.0214 0.1631
Schistosoma mansoni blooms syndrome DNA helicase 0.0011 0.0038 0.0029
Trypanosoma brucei DNA repair and recombination helicase protein PIF6 0.0061 0.1303 0.72
Brugia malayi eukaryotic initiation factor 4A 0.0024 0.0362 0.0601
Echinococcus multilocularis Polycystic kidney disease protein 0.0021 0.0287 0.0278
Loa Loa (eye worm) hypothetical protein 0.0022 0.0298 0.0493
Echinococcus multilocularis lipoxygenase domain containing protein 0.0021 0.0287 0.0278
Loa Loa (eye worm) hypothetical protein 0.0041 0.0806 0.1358
Echinococcus multilocularis dnaJ subfamily B 0.0403 1 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0057 0.0082
Plasmodium falciparum eukaryotic initiation factor 4A 0.0024 0.0362 0.7804
Schistosoma mansoni opsin-like receptor 0.0012 0.0057 0.0048
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0012 0.0057 0.0048
Loa Loa (eye worm) hypothetical protein 0.0022 0.0298 0.0493
Brugia malayi bZIP transcription factor family protein 0.0173 0.4148 0.7051
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0012 0.0057 0.0082
Brugia malayi Dopamine receptor protein 1 0.0012 0.0057 0.0082
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.004 0.0053
Brugia malayi hypothetical protein 0.0012 0.0057 0.0082
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0022 0.0298 0.0493
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0017 0.0192 0.0184
Loa Loa (eye worm) hypothetical protein 0.0015 0.0129 0.0205

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 15 uM Ability to inhibit expression of Vascular cell adhesion molecule 1 ChEMBL. 11459640
IC50 (binding) = 15 uM Ability to inhibit expression of Vascular cell adhesion molecule 1 ChEMBL. 11459640

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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