Detailed information for compound 787257

Basic information

Technical information
  • TDR Targets ID: 787257
  • Name: 1-acetyl-N-(3,5-dimethoxyphenyl)-2-methyl-2,3 -dihydroindole-5-sulfonamide
  • MW: 390.453 | Formula: C19H22N2O5S
  • H donors: 1 H acceptors: 3 LogP: 2.21 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(cc(c1)OC)NS(=O)(=O)c1ccc2c(c1)CC(N2C(=O)C)C
  • InChi: 1S/C19H22N2O5S/c1-12-7-14-8-18(5-6-19(14)21(12)13(2)22)27(23,24)20-15-9-16(25-3)11-17(10-15)26-4/h5-6,8-12,20H,7H2,1-4H3
  • InChiKey: CMXXKTOTXAILSW-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-acetyl-N-(3,5-dimethoxyphenyl)-2-methyl-indoline-5-sulfonamide
  • 1-acetyl-N-(3,5-dimethoxyphenyl)-2-methyl-5-indolinesulfonamide
  • N-(3,5-dimethoxyphenyl)-1-ethanoyl-2-methyl-2,3-dihydroindole-5-sulfonamide
  • EU-0092411

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) patched family protein 0.0018 0.0039 0.0183
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0285 0.1136 0.4645
Brugia malayi Death domain containing protein 0.0032 0.0095 0.0457
Trypanosoma brucei GMP reductase 0.0107 0.0406 0.1644
Echinococcus granulosus Niemann Pick C1 protein 0.0424 0.1706 0.6276
Mycobacterium ulcerans acyl-CoA synthetase 0.007 0.0253 0.0457
Echinococcus multilocularis dnaJ subfamily B 0.0404 0.1624 0.1624
Brugia malayi Patched family protein 0.0018 0.0039 0.0185
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0021 0.005 0.009
Echinococcus multilocularis regulator of G protein signaling 7 0.0009 0.0003 0.0003
Brugia malayi hypothetical protein 0.0308 0.123 0.5948
Schistosoma mansoni ankyrin 23/unc44 0.0032 0.0095 0.035
Schistosoma mansoni hypothetical protein 0.0109 0.0413 0.152
Plasmodium falciparum lipid/sterol:H+ symporter 0.0018 0.0039 0.0835
Onchocerca volvulus 0.0028 0.0082 0.0585
Trichomonas vaginalis antibiotic synthetase, putative 0.0021 0.005 0.024
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.005 0.009
Schistosoma mansoni microtubule-associated protein tau 0.0671 0.2719 1
Mycobacterium ulcerans AcrR family transcriptional regulator 0.1354 0.5524 1
Brugia malayi mbt repeat family protein 0.0046 0.0155 0.0746
Loa Loa (eye worm) hypothetical protein 0.0018 0.0039 0.0183
Loa Loa (eye worm) hypothetical protein 0.001 0.0006 0.0022
Trypanosoma cruzi GMP reductase 0.0107 0.0406 0.1644
Onchocerca volvulus 0.0308 0.123 0.9146
Toxoplasma gondii IMP dehydrogenas 0.0107 0.0406 1
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0021 0.005 0.009
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0021 0.005 0.009
Loa Loa (eye worm) hypothetical protein 0.0018 0.0039 0.0183
Brugia malayi TAR-binding protein 0.0378 0.1517 0.7335
Loa Loa (eye worm) hypothetical protein 0.0018 0.0039 0.0183
Loa Loa (eye worm) DIX domain-containing protein 0.0009 0.0003 0.001
Toxoplasma gondii patched family protein 0.0018 0.0039 0.089
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0006 0.0027
Loa Loa (eye worm) hypothetical protein 0.0018 0.0039 0.0183
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0111 0.0535
Echinococcus multilocularis tar DNA binding protein 0.0378 0.1517 0.1517
Trichomonas vaginalis glucosylceramidase, putative 0.0336 0.1345 0.6503
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0021 0.005 0.1152
Loa Loa (eye worm) hypothetical protein 0.0018 0.0039 0.0183
Trichomonas vaginalis replication factor C large subunit, putative 0.001 0.0006 0.0027
Brugia malayi CHE-14 protein 0.0127 0.0488 0.2358
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0049 0.0168 0.0305
Onchocerca volvulus Protein patched homolog 0.0018 0.0039 0.0267
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.007 0.0253 0.0457
Loa Loa (eye worm) hypothetical protein 0.0052 0.018 0.0866
Mycobacterium leprae PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+]) 0.001 0.0006 0.001
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0021 0.005 0.0236
Echinococcus granulosus polycomb protein SCMH1 0.0046 0.0155 0.057
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0085 0.0313 0.1263
Echinococcus granulosus regulator of G protein signaling 7 0.0009 0.0003 0.0012
Brugia malayi regulator of G-protein signaling egl-10 0.0009 0.0003 0.0012
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0049 0.0168 0.0305
Trichomonas vaginalis glucosylceramidase, putative 0.0512 0.2067 1
Schistosoma mansoni hypothetical protein 0.0079 0.0291 0.1069
Echinococcus granulosus regulator of G protein signaling 7 0.0009 0.0003 0.0012
Onchocerca volvulus Protein patched homolog 0.0018 0.0039 0.0267
Echinococcus granulosus expressed conserved protein 0.0279 0.111 0.4081
Schistosoma mansoni tar DNA-binding protein 0.0378 0.1517 0.5579
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0032 0.0096 0.0352
Echinococcus granulosus Ankyrin 0.0032 0.0096 0.0352
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0111 0.0535
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0111 0.0535
Mycobacterium ulcerans acyl-CoA synthetase 0.007 0.0253 0.0457
Schistosoma mansoni hypothetical protein 0.0079 0.0291 0.1069
Schistosoma mansoni netrin receptor unc5 0.0032 0.0095 0.035
Entamoeba histolytica acyl-coA synthetase, putative 0.007 0.0253 0.2098
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0109 0.0413 0.152
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0111 0.0431
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0182 0.0713 0.2622
Mycobacterium ulcerans hypothetical protein 0.007 0.0253 0.0457
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0021 0.005 0.0182
Plasmodium vivax inosine-5'-monophosphate dehydrogenase, putative 0.0107 0.0406 1
Leishmania major inosine-5-monophosphate dehydrogenase 0.0107 0.0406 0.149
Loa Loa (eye worm) hypothetical protein 0.0021 0.005 0.0234
Loa Loa (eye worm) hypothetical protein 0.0171 0.0669 0.323
Echinococcus granulosus dnaJ subfamily B 0.0404 0.1624 0.5974
Brugia malayi Calcitonin receptor-like protein seb-1 0.0251 0.0994 0.4807
Echinococcus multilocularis cpg binding protein 0.003 0.0088 0.0088
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0021 0.005 0.0181
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0251 0.0994 0.4807
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.005 0.009
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0603 0.2439 1
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0111 0.02
Schistosoma mansoni hypothetical protein 0.0079 0.0291 0.1069
Loa Loa (eye worm) hypothetical protein 0.0156 0.0606 0.2925
Loa Loa (eye worm) hypothetical protein 0.0018 0.0039 0.0183
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.007 0.0253 0.0457
Mycobacterium ulcerans inosine 5'-monophosphate dehydrogenase 0.0107 0.0406 0.0734
Loa Loa (eye worm) hypothetical protein 0.0035 0.0111 0.0529
Echinococcus granulosus cpg binding protein 0.003 0.0088 0.0325
Trypanosoma brucei inosine-5'-monophosphate dehydrogenase 0.0107 0.0406 0.1644
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0021 0.005 0.0181
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0053 0.0181 0.0873
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.005 0.009
Brugia malayi latrophilin 2 splice variant baaae 0.0171 0.0669 0.3231
Schistosoma mansoni hypothetical protein 0.0338 0.1351 0.4969
Echinococcus multilocularis nuclear factor of activated T cells 5 0.031 0.1237 0.1237
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0085 0.0313 0.1263
Brugia malayi Niemann-Pick C1 protein precursor 0.0297 0.1183 0.5723
Loa Loa (eye worm) hypothetical protein 0.0018 0.0039 0.0183
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.007 0.0253 0.0457
Echinococcus multilocularis regulator of G protein signaling 7 0.0009 0.0003 0.0003
Brugia malayi Patched family protein 0.0018 0.0039 0.0185
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.007 0.0253 0.0457
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0021 0.005 0.009
Loa Loa (eye worm) hypothetical protein 0.0018 0.0039 0.0183
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.005 0.009
Echinococcus multilocularis segment polarity protein dishevelled 0.0009 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0079 0.0291 0.1401
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.001 0.0006 0.0027
Schistosoma mansoni regulator of G protein signaling 0.0009 0.0003 0.0012
Loa Loa (eye worm) hypothetical protein 0.0018 0.0039 0.0183
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0182 0.0713 0.0713
Mycobacterium ulcerans transcriptional regulator 0.1354 0.5524 1
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0111 0.02
Brugia malayi Patched family protein 0.0018 0.0039 0.0185
Loa Loa (eye worm) hypothetical protein 0.0018 0.0039 0.0183
Loa Loa (eye worm) mbt repeat family protein 0.0046 0.0155 0.0744
Brugia malayi Patched related family protein 10 0.0018 0.0039 0.0185
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.009 0.0335 0.0335
Trichomonas vaginalis glucosylceramidase, putative 0.0512 0.2067 1
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0009 0.0003 0.001
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0111 0.02
Loa Loa (eye worm) hypothetical protein 0.0035 0.0111 0.0529
Wolbachia endosymbiont of Brugia malayi NAD-dependent DNA ligase, Lig 0.001 0.0006 0.0139
Loa Loa (eye worm) MBCTL1 0.0053 0.0181 0.0871
Mycobacterium ulcerans NAD-dependent DNA ligase LigA 0.001 0.0006 0.001
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0107 0.0406 0.1644
Loa Loa (eye worm) GMP reductase 0.0047 0.016 0.0767
Schistosoma mansoni tar DNA-binding protein 0.0378 0.1517 0.5579
Mycobacterium leprae POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) 0.0021 0.005 0.009
Brugia malayi hypothetical protein 0.0009 0.0003 0.0012
Echinococcus granulosus microtubule associated protein 2 0.0671 0.2719 1
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0046 0.0155 0.1131
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0111 0.2624
Onchocerca volvulus Glucosylceramidase homolog 0.0336 0.1345 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.005 0.0234
Brugia malayi Patched protein homolog 1 0.0018 0.0039 0.0185
Mycobacterium leprae Probable transcriptional regulatory repressor protein (TetR-family) EthR 0.1354 0.5524 1
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0226 0.0894 0.1619
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.001 0.0006 0.006
Mycobacterium leprae Probable inosine-5'-monophosphate dehydrogenase GuaB3 (IMP dehydrogenase 2) (inosinic acid dehydrogenase) (inosinate dehydrogena 0.006 0.0211 0.0382
Loa Loa (eye worm) hypothetical protein 0.0018 0.0039 0.0183
Brugia malayi Patched family protein 0.0018 0.0039 0.0185
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0079 0.0291 0.1069
Brugia malayi Patched related family protein 12 0.0018 0.0039 0.0185
Loa Loa (eye worm) hypothetical protein 0.0046 0.0155 0.0744
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0021 0.005 0.009
Loa Loa (eye worm) IMP dehydrogenase 1 0.0107 0.0406 0.1957
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0111 0.02
Mycobacterium tuberculosis Conserved protein 0.0035 0.0111 0.02
Toxoplasma gondii ATPase, AAA family protein 0.001 0.0006 0.006
Schistosoma mansoni hypothetical protein 0.0404 0.1624 0.5974
Loa Loa (eye worm) hypothetical protein 0.0188 0.0739 0.3569
Entamoeba histolytica acyl-CoA synthetase, putative 0.007 0.0253 0.2098
Loa Loa (eye worm) patched family protein 0.0018 0.0039 0.0183
Schistosoma mansoni patched 1 0.0127 0.0488 0.1795
Leishmania major mitochondrial DNA polymerase beta 0.0603 0.2439 1
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0512 0.2067 1
Echinococcus multilocularis protein dispatched 1 0.0145 0.0562 0.0562
Entamoeba histolytica hypothetical protein 0.0109 0.0413 0.3462
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0378 0.1517 0.7335
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.009 0.0335 0.0335
Brugia malayi Patched family protein 0.0018 0.0039 0.0185
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.005 0.009
Echinococcus multilocularis inosine 5' monophosphate dehydrogenase 2 0.0107 0.0406 0.0406
Mycobacterium leprae PROBABLE INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE GUAB1(IMP DEHYDROGENASE) (IMPDH) (IMPD) 0.0047 0.016 0.0289
Loa Loa (eye worm) hypothetical protein 0.0035 0.0111 0.0529
Trichomonas vaginalis glucosylceramidase, putative 0.0354 0.1419 0.6863
Loa Loa (eye worm) hypothetical protein 0.0032 0.0096 0.0458
Brugia malayi DIX domain containing protein 0.0009 0.0003 0.0012
Loa Loa (eye worm) hypothetical protein 0.0032 0.0095 0.0455
Brugia malayi AMP-binding enzyme family protein 0.007 0.0253 0.1219
Schistosoma mansoni inosine-5-monophosphate dehydrogenase 0.0107 0.0406 0.1492
Brugia malayi AMP-binding enzyme family protein 0.007 0.0253 0.1219
Mycobacterium ulcerans acyl-CoA synthetase 0.007 0.0253 0.0457
Onchocerca volvulus 0.0035 0.0111 0.08
Schistosoma mansoni acetyl-CoA synthetase 0.0021 0.005 0.0182
Giardia lamblia Replication factor C, subunit 1 0.001 0.0006 0.5
Onchocerca volvulus 0.0028 0.0081 0.0578
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0079 0.0291 0.0291
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0297 0.1183 1
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0111 0.02
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0049 0.0168 0.0305
Echinococcus granulosus geminin 0.0338 0.1351 0.4969
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0251 0.0994 0.4806
Mycobacterium ulcerans beta-lactamase 0.0035 0.0111 0.02
Trichomonas vaginalis glucosylceramidase, putative 0.0336 0.1345 0.6503
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0512 0.2067 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0039 0.0183
Loa Loa (eye worm) hypothetical protein 0.0009 0.0003 0.001
Toxoplasma gondii ABC1 family protein 0.0035 0.0111 0.2668
Echinococcus multilocularis nibrin 0.001 0.0006 0.0006
Echinococcus granulosus inosine 5' monophosphate dehydrogenase 2 0.0107 0.0406 0.1492
Trichomonas vaginalis glucosylceramidase, putative 0.0512 0.2067 1
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0021 0.005 0.0236
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0021 0.005 0.0181
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0021 0.005 0.1099
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0032 0.0095 0.0095
Schistosoma mansoni transcription factor LCR-F1 0.0109 0.0413 0.152
Trypanosoma cruzi GMP reductase 0.0107 0.0406 0.1644
Trichomonas vaginalis glucosylceramidase, putative 0.0336 0.1345 0.6503
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.005 0.009
Mycobacterium ulcerans TetR family transcriptional regulator 0.1354 0.5524 1
Loa Loa (eye worm) hypothetical protein 0.0251 0.0994 0.4806
Brugia malayi topoisomerase 0.001 0.0006 0.0024
Loa Loa (eye worm) hypothetical protein 0.0018 0.0039 0.0183
Brugia malayi beta-lactamase family protein 0.0035 0.0111 0.0532
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0111 0.02
Entamoeba histolytica acyl-CoA synthetase, putative 0.007 0.0253 0.2098
Echinococcus granulosus SAM and MBT domain containing protein 0.0046 0.0155 0.057
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0021 0.005 0.0181
Trichomonas vaginalis glucosylceramidase, putative 0.0512 0.2067 1
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0046 0.0155 0.057
Loa Loa (eye worm) hypothetical protein 0.0018 0.0039 0.0183
Echinococcus granulosus netrin receptor unc 5 0.0032 0.0095 0.035
Loa Loa (eye worm) hypothetical protein 0.0018 0.0039 0.0183
Schistosoma mansoni tar DNA-binding protein 0.0378 0.1517 0.5579
Loa Loa (eye worm) patched family protein 0.0018 0.0039 0.0183
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.005 0.009
Echinococcus multilocularis geminin 0.0338 0.1351 0.1351
Brugia malayi inosine-5'-monophosphate dehydrogenase 0.0047 0.016 0.0769
Brugia malayi hypothetical protein 0.001 0.0006 0.0024
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.001 0.0006 0.0024
Leishmania major guanosine monophosphate reductase 0.0107 0.0406 0.149
Loa Loa (eye worm) hypothetical protein 0.0127 0.0488 0.2356
Mycobacterium leprae Probable inosine-5'-monophosphate dehydrogenase GuaB2 (IMP dehydrogenase) (IMPDH) (IMPD) 0.0107 0.0406 0.0734
Echinococcus granulosus Protein patched homolog 1 0.0127 0.0488 0.1795
Echinococcus multilocularis Niemann Pick C1 protein 0.0297 0.1183 0.1183
Brugia malayi Patched related family protein 4 0.0018 0.0039 0.0185
Loa Loa (eye worm) hypothetical protein 0.0009 0.0003 0.001
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0021 0.005 0.009
Brugia malayi Myosin head containing protein 0.0018 0.0039 0.0185
Schistosoma mansoni sex comb on midleg homolog 0.0046 0.0155 0.057
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0001 0.0001
Brugia malayi Immunoglobulin I-set domain containing protein 0.0032 0.0095 0.0457
Plasmodium vivax acyl-CoA synthetase, putative 0.0052 0.018 0.436
Brugia malayi hypothetical protein 0.0009 0.0003 0.0012
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0111 0.0532
Schistosoma mansoni hypothetical protein 0.0032 0.0095 0.035
Onchocerca volvulus 0.0018 0.0039 0.0267
Loa Loa (eye worm) oxidoreductase 0.0021 0.005 0.0234
Mycobacterium ulcerans acetyl-CoA synthetase 0.0021 0.005 0.009
Onchocerca volvulus 0.0018 0.0039 0.0267
Brugia malayi Patched family protein 0.0018 0.0039 0.0185
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0009 0.0003 0.0012
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0109 0.0413 0.0413
Loa Loa (eye worm) hypothetical protein 0.0052 0.018 0.0866
Schistosoma mansoni topbp1 0.001 0.0006 0.0021
Loa Loa (eye worm) hypothetical protein 0.0052 0.018 0.0866
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.009 0.0335 0.1617
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0111 0.02
Trichomonas vaginalis glucosylceramidase, putative 0.0512 0.2067 1
Trichomonas vaginalis glucosylceramidase, putative 0.0354 0.1419 0.6863
Plasmodium vivax acetyl-CoA synthetase, putative 0.0021 0.005 0.1099
Brugia malayi CXXC zinc finger family protein 0.0028 0.0082 0.0391
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0079 0.0291 0.1403
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.007 0.0253 0.0457
Loa Loa (eye worm) hypothetical protein 0.0035 0.0111 0.0529
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.005 0.009
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0021 0.005 0.0373
Onchocerca volvulus 0.0018 0.0039 0.0267
Brugia malayi mbt repeat family protein 0.0046 0.0155 0.0746
Schistosoma mansoni cpg binding protein 0.003 0.0088 0.0325
Brugia malayi Patched family protein 0.0018 0.0039 0.0185
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0021 0.005 0.0181
Schistosoma mansoni dishevelled 0.0009 0.0003 0.0012
Loa Loa (eye worm) hypothetical protein 0.0018 0.0039 0.0183
Brugia malayi Patched family protein 0.0018 0.0039 0.0185
Loa Loa (eye worm) hypothetical protein 0.0018 0.0039 0.0183
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0603 0.2439 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.009 0.0335 0.1615
Onchocerca volvulus 0.0021 0.005 0.0346
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.005 0.009
Brugia malayi hypothetical protein 0.0018 0.0039 0.0185
Mycobacterium leprae Probable lipase LipE 0.0035 0.0111 0.02
Loa Loa (eye worm) latrophilin receptor protein 2 0.0079 0.0291 0.1401
Loa Loa (eye worm) hypothetical protein 0.001 0.0006 0.0022
Brugia malayi Patched family protein 0.0018 0.0039 0.0185
Mycobacterium leprae POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0021 0.005 0.009
Trichomonas vaginalis glucosylceramidase, putative 0.0336 0.1345 0.6503
Brugia malayi DKFZp564C0469 protein 0.001 0.0006 0.0024
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0085 0.0313 0.1263
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0111 0.0431
Echinococcus granulosus GPCR family 2 0.0079 0.0291 0.1069
Echinococcus granulosus nuclear factor of activated T cells 5 0.031 0.1237 0.455
Echinococcus multilocularis GPCR, family 2 0.0079 0.0291 0.0291
Loa Loa (eye worm) hypothetical protein 0.0018 0.0039 0.0183
Brugia malayi inosine-5'-monophosphate dehydrogenase 0.0047 0.016 0.0769
Brugia malayi AMP-binding enzyme family protein 0.0021 0.005 0.0236
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0285 0.1136 0.4547
Mycobacterium tuberculosis Conserved protein 0.0035 0.0111 0.02
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0111 0.0407
Mycobacterium ulcerans hypothetical protein 0.0035 0.0111 0.02
Brugia malayi Latrophilin receptor protein 2 0.0079 0.0291 0.1403
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0009 0.0003 0.0012
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0188 0.0739 0.5482
Loa Loa (eye worm) hypothetical protein 0.0018 0.0039 0.0183
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0285 0.1136 0.4645
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.009 0.0335 0.1232
Brugia malayi hypothetical protein 0.0018 0.0039 0.0185
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0111 0.0535
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0111 0.0407
Schistosoma mansoni tar DNA-binding protein 0.0378 0.1517 0.5579
Toxoplasma gondii propionate-CoA ligase 0.0021 0.005 0.1152
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0032 0.0095 0.035
Echinococcus granulosus Pleckstrin G protein interacting region 0.0009 0.0003 0.0012
Mycobacterium ulcerans fatty-acid-CoA ligase 0.007 0.0253 0.0457
Toxoplasma gondii patched family protein 0.0018 0.0039 0.089
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0052 0.018 0.0326
Onchocerca volvulus 0.0035 0.0111 0.08
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.005 0.009
Toxoplasma gondii histone lysine methyltransferase SET1 0.0054 0.0186 0.4539
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0006 0.0027
Loa Loa (eye worm) hypothetical protein 0.0018 0.0039 0.0183
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0111 0.0535
Onchocerca volvulus 0.0021 0.005 0.0346
Loa Loa (eye worm) hypothetical protein 0.0018 0.0039 0.0183
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.001 0.0006 0.0027
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0018 0.0038 0.0069
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0111 0.0431
Loa Loa (eye worm) hypothetical protein 0.0018 0.0039 0.0183
Brugia malayi inosine-5'-monophosphate dehydrogenase family protein 0.0107 0.0406 0.1959
Echinococcus granulosus tar DNA binding protein 0.0378 0.1517 0.5579
Brugia malayi hypothetical protein 0.0109 0.0413 0.1997
Echinococcus multilocularis SAM and MBT domain containing protein 0.0046 0.0155 0.0155
Mycobacterium tuberculosis Probable inosine-5'-monophosphate dehydrogenase GuaB2 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase 0.0107 0.0406 0.0734
Brugia malayi N-terminal motif family protein 0.0188 0.0739 0.357
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.001 0.0006 0.0027
Brugia malayi beta-lactamase 0.0035 0.0111 0.0532
Schistosoma mansoni tar DNA-binding protein 0.0378 0.1517 0.5579
Mycobacterium tuberculosis Conserved hypothetical protein 0.0317 0.1268 0.2295
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0107 0.0406 0.1644
Brugia malayi protein C24B5.3 0.0018 0.0039 0.0185
Trichomonas vaginalis esterase, putative 0.0035 0.0111 0.0535
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0006 0.0027
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.005 0.009
Trichomonas vaginalis glucosylceramidase, putative 0.0336 0.1345 0.6503
Brugia malayi Patched family protein 0.0018 0.0039 0.0185
Onchocerca volvulus 0.0018 0.0039 0.0267
Brugia malayi Pax transcription activation domain interacting protein 0.001 0.0006 0.0024
Schistosoma mansoni cpg binding protein 0.003 0.0088 0.0325
Schistosoma mansoni hypothetical protein 0.0171 0.0669 0.2459
Echinococcus multilocularis Ankyrin 0.0032 0.0096 0.0096
Onchocerca volvulus Netrin receptor homolog 0.0032 0.0095 0.0686
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0111 0.0529
Loa Loa (eye worm) hypothetical protein 0.0018 0.0039 0.0183
Schistosoma mansoni hypothetical protein 0.0123 0.0469 0.1726
Brugia malayi Patched family protein 0.0018 0.0039 0.0185
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0021 0.005 0.0234
Onchocerca volvulus 0.0018 0.0039 0.0267
Brugia malayi protein C24B5.3 0.0018 0.0039 0.0185
Trichomonas vaginalis antibiotic synthetase, putative 0.0021 0.005 0.024
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0032 0.0095 0.0455
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0079 0.0291 0.0291
Loa Loa (eye worm) hypothetical protein 0.0018 0.0039 0.0183
Leishmania major 4-coumarate:coa ligase-like protein 0.007 0.0253 0.085
Loa Loa (eye worm) TAR-binding protein 0.0378 0.1517 0.7335
Echinococcus granulosus histone acetyltransferase MYST2 0.0053 0.0181 0.0666
Schistosoma mansoni hypothetical protein 0.0123 0.0469 0.1726
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0107 0.0406 0.1644
Loa Loa (eye worm) hypothetical protein 0.0018 0.0039 0.0183
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0021 0.005 0.009
Loa Loa (eye worm) hypothetical protein 0.0018 0.0039 0.0183
Echinococcus multilocularis histone acetyltransferase MYST2 0.0053 0.0181 0.0181
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0021 0.005 0.009
Mycobacterium ulcerans inosine 5-monophosphate dehydrogenase 0.0107 0.0406 0.0734
Brugia malayi hypothetical protein 0.0018 0.0039 0.0185
Leishmania major hypothetical protein, conserved 0.0035 0.0111 0.0255
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.007 0.0253 0.0457
Onchocerca volvulus 0.0021 0.005 0.0346
Brugia malayi RNA binding protein 0.0378 0.1517 0.7335
Loa Loa (eye worm) hypothetical protein 0.0018 0.0039 0.0183
Loa Loa (eye worm) hypothetical protein 0.001 0.0006 0.0022
Loa Loa (eye worm) hypothetical protein 0.007 0.0253 0.1217
Brugia malayi AMP-binding enzyme family protein 0.007 0.0253 0.1219
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0082 0.0389
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0021 0.005 0.009
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0049 0.0168 0.0305
Toxoplasma gondii patched family protein 0.0018 0.0039 0.089
Mycobacterium ulcerans lipase LipD 0.0035 0.0111 0.02
Schistosoma mansoni myelin transcription factor 1 myt1 0.0053 0.0181 0.0666
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0021 0.005 0.1152
Entamoeba histolytica hypothetical protein 0.0109 0.0413 0.3462
Brugia malayi Protein kinase domain containing protein 0.0032 0.0095 0.0457
Echinococcus multilocularis Pleckstrin G protein, interacting region 0.0009 0.0003 0.0003
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0021 0.005 0.009
Loa Loa (eye worm) hypothetical protein 0.001 0.0006 0.0022
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.009 0.0335 0.1232
Echinococcus granulosus death domain containing protein 0.0032 0.0095 0.035
Echinococcus granulosus segment polarity protein dishevelled 0.0009 0.0003 0.0012
Schistosoma mansoni hypothetical protein 0.0338 0.1351 0.4969
Brugia malayi AMP-binding enzyme family protein 0.0021 0.005 0.0236
Trichomonas vaginalis conserved hypothetical protein 0.0127 0.0488 0.236
Brugia malayi Patched family protein 0.0018 0.0039 0.0185
Mycobacterium tuberculosis Conserved protein 0.0035 0.0111 0.02
Brugia malayi Patched family protein 0.0018 0.0039 0.0185
Mycobacterium ulcerans inosine 5-monophosphate dehydrogenase 0.0047 0.016 0.0289
Trichomonas vaginalis glucosylceramidase, putative 0.0336 0.1345 0.6503
Brugia malayi GMP reductase 0.0047 0.016 0.0769
Schistosoma mansoni hypothetical protein 0.0079 0.0291 0.1069
Wolbachia endosymbiont of Brugia malayi IMP dehydrogenase 0.0107 0.0406 1
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0053 0.0181 0.0666
Brugia malayi Patched family protein 0.0018 0.0039 0.0185
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0103 0.0389 0.1576
Onchocerca volvulus 0.0035 0.0111 0.08
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.0335 0.1232
Echinococcus multilocularis replication factor c subunit 1 0.001 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0035 0.0111 0.0529
Loa Loa (eye worm) hypothetical protein 0.0052 0.018 0.0866
Entamoeba histolytica hypothetical protein 0.0109 0.0413 0.3462
Schistosoma mansoni fyve finger-containing phosphoinositide kinase fyv1 0.0009 0.0003 0.0012
Toxoplasma gondii hypothetical protein 0.0097 0.0364 0.8969
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0111 0.02
Brugia malayi Patched family protein 0.0018 0.0039 0.0185
Onchocerca volvulus 0.0018 0.0039 0.0267
Loa Loa (eye worm) hypothetical protein 0.0018 0.0039 0.0183
Echinococcus multilocularis segment polarity protein dishevelled 0.0009 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0052 0.018 0.0866
Schistosoma mansoni hypothetical protein 0.0123 0.0469 0.1726
Loa Loa (eye worm) hypothetical protein 0.007 0.0253 0.1217
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0001 0.0004
Trichomonas vaginalis glucosylceramidase, putative 0.0512 0.2067 1
Treponema pallidum DNA ligase (lig) 0.001 0.0006 1
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0021 0.005 0.005
Onchocerca volvulus 0.0018 0.0039 0.0267
Loa Loa (eye worm) hypothetical protein 0.0018 0.0039 0.0183
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.007 0.0253 0.0457
Mycobacterium tuberculosis Probable inosine-5'-monophosphate dehydrogenase GuaB3 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase 0.006 0.0211 0.0382
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0021 0.005 0.009
Toxoplasma gondii hypothetical protein 0.0018 0.0039 0.089
Echinococcus granulosus nibrin 0.001 0.0006 0.0021
Brugia malayi hypothetical protein 0.001 0.0006 0.0024
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0111 0.02
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.001 0.0006 0.0000029208
Schistosoma mansoni dep domain containing protein 0.0009 0.0003 0.0012
Leishmania major 4-coumarate:coa ligase-like protein 0.007 0.0253 0.085
Onchocerca volvulus Putative GMP reductase 0.0047 0.016 0.1167
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.005 0.009
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0111 0.0111
Loa Loa (eye worm) hypothetical protein 0.0035 0.0111 0.0529
Echinococcus multilocularis protein patched 0.0127 0.0488 0.0488
Echinococcus multilocularis Niemann Pick C1 protein 0.0424 0.1706 0.1706
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0021 0.005 0.009
Schistosoma mansoni DNA ligase IV 0.001 0.0006 0.0021
Loa Loa (eye worm) hypothetical protein 0.007 0.0253 0.1217
Loa Loa (eye worm) hypothetical protein 0.0018 0.0039 0.0183
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.0212 0.0781
Schistosoma mansoni chromosome transmission fidelity factor 0.001 0.0006 0.0021
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0085 0.0313 0.1263
Schistosoma mansoni hypothetical protein 0.0281 0.1119 0.4115
Loa Loa (eye worm) beta-lactamase 0.0035 0.0111 0.0529
Entamoeba histolytica hypothetical protein 0.0109 0.0413 0.3462
Loa Loa (eye worm) hypothetical protein 0.001 0.0006 0.0022
Brugia malayi AMP-binding enzyme family protein 0.0021 0.005 0.0236
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.0335 0.1232
Brugia malayi AMP-binding enzyme family protein 0.0021 0.005 0.0236
Loa Loa (eye worm) hypothetical protein 0.0053 0.0181 0.0871
Loa Loa (eye worm) hypothetical protein 0.0308 0.123 0.5947
Mycobacterium ulcerans hypothetical protein 0.0317 0.1268 0.2295
Plasmodium falciparum inosine-5'-monophosphate dehydrogenase 0.0107 0.0406 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0006 0.0022
Leishmania major 4-coumarate:coa ligase-like protein 0.007 0.0253 0.085
Loa Loa (eye worm) hypothetical protein 0.0297 0.1183 0.5722
Loa Loa (eye worm) hypothetical protein 0.0018 0.0039 0.0183
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.0335 0.1232
Plasmodium falciparum acyl-CoA synthetase 0.0052 0.018 0.436
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0053 0.0181 0.0181
Echinococcus multilocularis expressed conserved protein 0.0279 0.111 0.111
Echinococcus granulosus segment polarity protein dishevelled 0.0009 0.0003 0.0012
Echinococcus multilocularis netrin receptor unc 5 0.0032 0.0095 0.0095
Brugia malayi Uncoordinated protein 44 0.0032 0.0095 0.0457
Onchocerca volvulus 0.007 0.0253 0.186
Echinococcus granulosus sterol regulatory element binding protein 0.0127 0.0488 0.1795
Echinococcus multilocularis polycomb protein SCMH1 0.0046 0.0155 0.0155
Loa Loa (eye worm) hypothetical protein 0.0018 0.0039 0.0183
Echinococcus multilocularis microtubule associated protein 2 0.0671 0.2719 0.2719
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0021 0.005 0.009
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0021 0.005 0.0234
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0603 0.2439 1
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0021 0.005 0.009
Loa Loa (eye worm) patched family protein 0.0018 0.0039 0.0183
Echinococcus granulosus Niemann Pick C1 protein 0.0297 0.1183 0.4353
Schistosoma mansoni z-protein (S1r protein) 0.0009 0.0003 0.0012
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0079 0.0291 0.1069
Schistosoma mansoni dishevelled 0.0009 0.0003 0.0012
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.001 0.0006 0.0027
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0021 0.005 0.009
Loa Loa (eye worm) patched family protein 0.0018 0.0039 0.0183
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0006 0.0027
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0006 0.0027
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0052 0.018 1
Schistosoma mansoni hypothetical protein 0.0123 0.0469 0.1726
Echinococcus granulosus replication factor c subunit 1 0.001 0.0006 0.0021
Brugia malayi hypothetical protein 0.0018 0.0039 0.0185
Toxoplasma gondii patched family protein 0.0018 0.0039 0.089
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0127 0.0488 0.2356
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0021 0.005 0.0181
Onchocerca volvulus 0.0046 0.0155 0.1131
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0021 0.005 0.009
Loa Loa (eye worm) hypothetical protein 0.0009 0.0003 0.001
Onchocerca volvulus 0.001 0.0006 0.0018
Schistosoma mansoni topbp1 0.001 0.0006 0.0021
Echinococcus multilocularis sterol regulatory element binding protein 0.0127 0.0488 0.0488
Plasmodium vivax patched family protein, putative 0.0018 0.0039 0.0835
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0301 0.1202 0.4423
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0111 0.02
Loa Loa (eye worm) RNA binding protein 0.0378 0.1517 0.7335
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0052 0.018 0.0326
Mycobacterium tuberculosis Transcriptional regulatory repressor protein (TetR-family) EthR 0.1354 0.5524 1
Schistosoma mansoni sex comb on midleg homolog 0.0046 0.0155 0.057
Schistosoma mansoni cpg binding protein 0.0028 0.0082 0.03
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0111 0.0407
Trichomonas vaginalis glucosylceramidase, putative 0.0336 0.1345 0.6503
Brugia malayi beta-lactamase family protein 0.0035 0.0111 0.0532
Brugia malayi RNA recognition motif domain containing protein 0.0378 0.1517 0.7335

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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