Detailed information for compound 793411

Basic information

Technical information
  • TDR Targets ID: 793411
  • Name: 2-methoxy-N-[1-(1-pentylbenzimidazol-2-yl)eth yl]benzamide
  • MW: 365.469 | Formula: C22H27N3O2
  • H donors: 1 H acceptors: 2 LogP: 4.34 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCCn1c(nc2c1cccc2)C(NC(=O)c1ccccc1OC)C
  • InChi: 1S/C22H27N3O2/c1-4-5-10-15-25-19-13-8-7-12-18(19)24-21(25)16(2)23-22(26)17-11-6-9-14-20(17)27-3/h6-9,11-14,16H,4-5,10,15H2,1-3H3,(H,23,26)
  • InChiKey: CQBIMXSHUZUSNJ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-methoxy-N-[1-(1-pentyl-2-benzimidazolyl)ethyl]benzamide
  • N-[1-(1-amylbenzimidazol-2-yl)ethyl]-2-methoxy-benzamide
  • T5458245

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium vivax pyruvate kinase 2, putative 0.0034 0.0046 0.1203
Schistosoma mansoni ran 0.0043 0.0072 0.02
Trichomonas vaginalis pyruvate kinase, putative 0.0067 0.0141 0.1153
Loa Loa (eye worm) hypothetical protein 0.0205 0.054 0.1023
Brugia malayi Pyruvate kinase, M2 isozyme 0.0067 0.0141 0.0265
Echinococcus multilocularis Niemann Pick C1 protein 0.0151 0.0384 0.0384
Echinococcus granulosus Niemann Pick C1 protein 0.0105 0.0252 0.0595
Schistosoma mansoni hypothetical protein 0.0044 0.0073 0.0204
Brugia malayi Pyruvate kinase, alpha/beta domain containing protein 0.002 0.0005 0.0007
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0036 0.005 0.0167
Echinococcus granulosus sterol regulatory element binding protein 0.0045 0.0078 0.0183
Echinococcus multilocularis snurportin 1 0.0625 0.1761 0.1761
Brugia malayi AMP-binding enzyme family protein 0.005 0.0092 0.0173
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0107 0.0256 0.1251
Toxoplasma gondii isocitrate dehydrogenase 0.0051 0.0093 0.208
Echinococcus granulosus fetal alzheimer antigen falz 0.0024 0.0017 0.0041
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0043 0.0072 0.0133
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0041 0.0066 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0048 0.0085 0.0237
Trichomonas vaginalis importin beta-1, putative 0.0048 0.0084 0.0277
Loa Loa (eye worm) latrophilin receptor protein 2 0.0065 0.0134 0.0252
Echinococcus granulosus geminin 0.1252 0.3578 0.8446
Mycobacterium tuberculosis Probable reductase 0.0111 0.0269 0.1317
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0107 0.0256 0.1251
Plasmodium falciparum ataxin-2 like protein, putative 0.0081 0.0182 1
Brugia malayi Kelch motif family protein 0.0049 0.0089 0.0167
Echinococcus multilocularis zinc finger protein 0.0021 0.0008 0.0008
Echinococcus granulosus microtubule associated protein 2 0.0674 0.1903 0.4492
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0096 0.0226 0.0226
Loa Loa (eye worm) isocitrate dehydrogenase 0.0051 0.0093 0.0174
Loa Loa (eye worm) hypothetical protein 0.0049 0.0089 0.0167
Brugia malayi AMP-binding enzyme family protein 0.005 0.0092 0.0173
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0031 0.0031
Brugia malayi TAR-binding protein 0.031 0.0846 0.1602
Leishmania major hypothetical protein, conserved 0.0107 0.0256 0.0484
Brugia malayi Inositol-1 0.0041 0.0066 0.0123
Schistosoma mansoni tar DNA-binding protein 0.031 0.0846 0.2363
Loa Loa (eye worm) hypothetical protein 0.0081 0.0182 0.0342
Loa Loa (eye worm) hypothetical protein 0.0067 0.0141 0.0265
Trichomonas vaginalis ran, putative 0.0043 0.0072 0.0081
Mycobacterium tuberculosis Probable dehydrogenase 0.0111 0.0269 0.1317
Schistosoma mansoni importin beta-1 0.0059 0.0116 0.0325
Loa Loa (eye worm) hypothetical protein 0.0047 0.0082 0.0153
Entamoeba histolytica hypothetical protein 0.0048 0.0084 0.2841
Brugia malayi hypothetical protein 0.0137 0.0344 0.065
Plasmodium falciparum acyl-CoA synthetase 0.0038 0.0055 0.2309
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0107 0.0256 0.0484
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0025 0.0018 0.0119
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0105 0.0252 1
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0074 0.0161 0.0379
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0116 0.0283 0.0669
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0102 0.0242 0.0678
Loa Loa (eye worm) hypothetical protein 0.0044 0.0074 0.0139
Loa Loa (eye worm) hypothetical protein 0.0045 0.0078 0.0145
Loa Loa (eye worm) MBCTL1 0.0116 0.0283 0.0535
Trypanosoma brucei pyruvate kinase 1 0.0067 0.0141 0.0265
Toxoplasma gondii ABC1 family protein 0.0107 0.0256 0.6583
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0041 0.0066 0.0123
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0051 0.0093 0.4593
Brugia malayi isocitrate dehydrogenase 0.0051 0.0093 0.0174
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0024 0.0017 0.0017
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0025 0.0018 0.0119
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0041 0.0066 0.0123
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0043 0.0072 0.3286
Echinococcus multilocularis muscleblind protein 1 0.0146 0.037 0.037
Schistosoma mansoni hypothetical protein 0.0065 0.0134 0.0376
Loa Loa (eye worm) hypothetical protein 0.0107 0.0256 0.0484
Mycobacterium tuberculosis Conserved protein 0.0107 0.0256 0.1251
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0124 0.0305 0.1506
Brugia malayi Pyruvate kinase, muscle isozyme 0.0067 0.0141 0.0265
Schistosoma mansoni pyruvate kinase 0.0034 0.0046 0.0129
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0051 0.0093 0.0395
Onchocerca volvulus Pyruvate kinase homolog 0.0067 0.0141 0.0492
Onchocerca volvulus 0.0107 0.0256 0.0899
Loa Loa (eye worm) hypothetical protein 0.0042 0.0067 0.0124
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0043 0.0072 0.0072
Loa Loa (eye worm) glutaminase 2 0.0265 0.0714 0.1352
Loa Loa (eye worm) hypothetical protein 0.0107 0.0256 0.0484
Schistosoma mansoni hypothetical protein 0.0625 0.1761 0.4922
Schistosoma mansoni patched 1 0.0045 0.0078 0.0217
Brugia malayi RNA binding protein 0.031 0.0846 0.1602
Onchocerca volvulus 0.0107 0.0256 0.0899
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0065 0.0134 0.0317
Loa Loa (eye worm) TAR-binding protein 0.031 0.0846 0.1602
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0072 0.0157 0.0157
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0037 0.0054 0.1257
Echinococcus granulosus beta LACTamase domain containing family member 0.0107 0.0256 0.0605
Schistosoma mansoni hypothetical protein 0.0065 0.0134 0.0376
Trypanosoma cruzi pyruvate kinase 2, putative 0.0067 0.0141 0.0265
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0036 0.005 0.0167
Schistosoma mansoni hypothetical protein 0.1252 0.3578 1
Trypanosoma brucei PAB1-binding protein , putative 0.0081 0.0182 0.0342
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0402 0.1113 0.2627
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0124 0.0305 1
Brugia malayi Isocitrate dehydrogenase 0.0051 0.0093 0.0174
Loa Loa (eye worm) hypothetical protein 0.0146 0.037 0.0699
Echinococcus multilocularis inositol monophosphatase 1 0.0041 0.0066 0.0066
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0039 0.0059 0.014
Brugia malayi ERG2 and Sigma1 receptor like protein 0.1836 0.5273 1
Echinococcus multilocularis pyruvate kinase 0.0034 0.0046 0.0046
Loa Loa (eye worm) hypothetical protein 0.0077 0.0169 0.0317
Echinococcus multilocularis vesicular acetylcholine transporter 0.0995 0.2833 0.2833
Brugia malayi hypothetical protein 0.0081 0.0182 0.0342
Echinococcus granulosus neuropeptide receptor A26 0.1479 0.4237 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0107 0.0256 0.0716
Trypanosoma cruzi pyruvate kinase 2, putative 0.0067 0.0141 0.0265
Mycobacterium tuberculosis Probable lipase LipD 0.0107 0.0256 0.1251
Trichomonas vaginalis set domain proteins, putative 0.0231 0.0618 0.8517
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0074 0.0161 0.0302
Mycobacterium tuberculosis Probable lipase LipE 0.0107 0.0256 0.1251
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.013 0.0325 0.0613
Loa Loa (eye worm) MH2 domain-containing protein 0.0244 0.0656 0.1242
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0096 0.0226 0.0427
Brugia malayi mbt repeat family protein 0.0102 0.0242 0.0457
Loa Loa (eye worm) hypothetical protein 0.0189 0.0496 0.0938
Loa Loa (eye worm) hypothetical protein 0.0938 0.2669 0.506
Loa Loa (eye worm) hypothetical protein 0.0137 0.0344 0.065
Trypanosoma brucei hypothetical protein, conserved 0.0107 0.0256 0.0484
Loa Loa (eye worm) PHD-finger family protein 0.0022 0.0011 0.0019
Plasmodium vivax SET domain protein, putative 0.0029 0.0031 0.0565
Giardia lamblia Pyruvate kinase 0.0067 0.0141 1
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0067 0.0141 0.0647
Loa Loa (eye worm) inositol-1 0.0041 0.0066 0.0123
Toxoplasma gondii thioredoxin reductase 0.0049 0.0088 0.1938
Echinococcus multilocularis thioredoxin glutathione reductase 0.0049 0.0088 0.0088
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0107 0.0256 0.0716
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.005 0.0092 0.0669
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0111 0.0269 0.1317
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0074 0.0161 0.0449
Mycobacterium tuberculosis Probable oxidoreductase 0.0124 0.0305 0.1506
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0625 0.1761 0.3339
Schistosoma mansoni hypothetical protein 0.062 0.1746 0.488
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.005 0.0092 0.0392
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0065 0.0134 0.0134
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.031 0.0846 0.1602
Echinococcus multilocularis geminin 0.1252 0.3578 0.3578
Plasmodium falciparum glutathione reductase 0.0049 0.0088 0.4279
Echinococcus granulosus tar DNA binding protein 0.031 0.0846 0.1996
Schistosoma mansoni hypothetical protein 0.0072 0.0157 0.0438
Schistosoma mansoni tar DNA-binding protein 0.031 0.0846 0.2363
Mycobacterium tuberculosis Probable esterase LipL 0.0107 0.0256 0.1251
Echinococcus granulosus importin subunit beta 1 0.0059 0.0116 0.0275
Plasmodium falciparum importin beta, putative 0.0059 0.0116 0.6021
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0065 0.0134 0.0134
Echinococcus multilocularis importin subunit beta 1 0.0059 0.0116 0.0116
Entamoeba histolytica Ran family GTPase 0.0043 0.0072 0.2299
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0043 0.0072 0.0133
Leishmania major pyruvate kinase 0.0067 0.0141 0.0265
Onchocerca volvulus 0.0653 0.1842 0.6501
Leishmania major 4-coumarate:coa ligase-like protein 0.005 0.0092 0.0173
Plasmodium falciparum thioredoxin reductase 0.0049 0.0088 0.4279
Echinococcus multilocularis isocitrate dehydrogenase 0.0051 0.0093 0.0093
Leishmania major pyruvate kinase 0.0067 0.0141 0.0265
Echinococcus granulosus transcription factor Dp 1 0.0043 0.007 0.0166
Echinococcus multilocularis neuropeptide s receptor 0.1479 0.4237 0.4237
Echinococcus multilocularis L aminoadipate semialdehyde 0.0087 0.02 0.02
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0031 0.0087
Brugia malayi Bromodomain containing protein 0.0081 0.0182 0.0343
Echinococcus granulosus neuropeptide s receptor 0.1479 0.4237 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0096 0.0226 0.0534
Plasmodium vivax glutathione reductase, putative 0.0049 0.0088 0.2943
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0065 0.0134 0.0134
Schistosoma mansoni microtubule-associated protein tau 0.0674 0.1903 0.5319
Mycobacterium ulcerans glutaminase 0.0265 0.0714 0.5236
Trichomonas vaginalis D-aminoacylase, putative 0.0107 0.0256 0.2932
Loa Loa (eye worm) hypothetical protein 0.0055 0.0107 0.0201
Brugia malayi hypothetical protein 0.0052 0.0098 0.0184
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0927 0.2636 0.4997
Entamoeba histolytica hypothetical protein 0.0072 0.0157 0.593
Mycobacterium tuberculosis Conserved hypothetical protein 0.0488 0.1363 0.7049
Onchocerca volvulus Huntingtin homolog 0.0137 0.0344 0.1209
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0048 0.0085 0.0237
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0024 0.0017 0.0048
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0072 0.0157 0.037
Toxoplasma gondii pyruvate kinase PyK1 0.0067 0.0141 0.3405
Loa Loa (eye worm) cytochrome P450 family protein 0.0048 0.0085 0.0158
Leishmania major mitochondrial DNA polymerase beta 0.0927 0.2636 0.4997
Toxoplasma gondii HEAT repeat-containing protein 0.0059 0.0116 0.2726
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0043 0.0072 0.0133
Loa Loa (eye worm) hypothetical protein 0.0038 0.0055 0.0103
Brugia malayi Importin beta-1 subunit 0.0059 0.0116 0.0218
Loa Loa (eye worm) integrin beta-2 0.0324 0.0888 0.1682
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.005 0.0092 0.0392
Plasmodium falciparum pyruvate kinase 2 0.0034 0.0046 0.1749
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0051 0.0093 0.3159
Loa Loa (eye worm) hypothetical protein 0.0137 0.0344 0.065
Echinococcus multilocularis neuropeptide receptor A26 0.1479 0.4237 0.4237
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.013 0.0325 0.0613
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.0031 0.0087
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0087 0.02 0.0558
Loa Loa (eye worm) hypothetical protein 0.005 0.0092 0.0173
Loa Loa (eye worm) mbt repeat family protein 0.0102 0.0242 0.0457
Mycobacterium leprae Probable pyruvate kinase PykA 0.0067 0.0141 0.4295
Schistosoma mansoni sex comb on midleg homolog 0.0102 0.0242 0.0678
Brugia malayi N-terminal motif family protein 0.0189 0.0496 0.0938
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0205 0.054 0.1023
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0065 0.0134 0.0252
Mycobacterium ulcerans beta-lactamase 0.0107 0.0256 0.1872
Brugia malayi mbt repeat family protein 0.0102 0.0242 0.0457
Loa Loa (eye worm) hypothetical protein 0.0107 0.0256 0.0484
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0051 0.0093 0.0093
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0111 0.0269 0.1317
Echinococcus granulosus thioredoxin glutathione reductase 0.0049 0.0088 0.0207
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0041 0.0066 0.0477
Echinococcus granulosus vesicular acetylcholine transporter 0.0995 0.2833 0.6686
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.005 0.0092 0.2603
Echinococcus granulosus snurportin 1 0.0625 0.1761 0.4157
Trypanosoma brucei pyruvate kinase 1, putative 0.0067 0.0141 0.0265
Plasmodium vivax ataxin-2 like protein, putative 0.0081 0.0182 0.6878
Trypanosoma cruzi PAB1-binding protein , putative 0.0081 0.0182 0.0342
Echinococcus granulosus pyruvate kinase 0.0034 0.0046 0.0109
Echinococcus granulosus L aminoadipate semialdehyde 0.0087 0.02 0.0471
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0039 0.0059 0.0059
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0049 0.0088 0.0368
Trypanosoma cruzi trypanothione reductase, putative 0.0049 0.0088 0.0164
Leishmania major importin beta-1 subunit, putative 0.0048 0.0084 0.0157
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0074 0.0161 0.0161
Loa Loa (eye worm) hypothetical protein 0.0105 0.0252 0.0476
Onchocerca volvulus Pyruvate kinase homolog 0.0067 0.0141 0.0492
Mycobacterium ulcerans esterase/lipase LipP 0.0107 0.0256 0.1872
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0048 0.0085 0.0085
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0074 0.0161 0.0302
Loa Loa (eye worm) hypothetical protein 0.0048 0.0085 0.0158
Echinococcus granulosus pyruvate kinase 0.0067 0.0141 0.0333
Echinococcus multilocularis GPCR, family 2 0.0065 0.0134 0.0134
Echinococcus multilocularis pyruvate kinase 0.0034 0.0046 0.0046
Loa Loa (eye worm) hypothetical protein 0.0038 0.0055 0.0103
Echinococcus granulosus GTP binding nuclear protein Ran 0.0043 0.0072 0.0169
Trypanosoma cruzi PAB1-binding protein , putative 0.0081 0.0182 0.0342
Loa Loa (eye worm) hypothetical protein 0.0102 0.0242 0.0457
Loa Loa (eye worm) hypothetical protein 0.0038 0.0055 0.0103
Chlamydia trachomatis pyruvate kinase 0.0067 0.0141 1
Echinococcus granulosus pyruvate kinase 0.0067 0.0141 0.0333
Schistosoma mansoni transcription factor LCR-F1 0.0072 0.0157 0.0438
Brugia malayi Niemann-Pick C1 protein precursor 0.0105 0.0252 0.0476
Toxoplasma gondii hypothetical protein 0.0149 0.038 1
Loa Loa (eye worm) pyruvate kinase 0.0067 0.0141 0.0265
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0111 0.0269 0.8748
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0203 0.0537 0.1015
Leishmania major hypothetical protein, conserved 0.0081 0.0182 0.0342
Trypanosoma brucei C-8 sterol isomerase, putative 0.1836 0.5273 1
Leishmania major GTP-binding protein, putative 0.0043 0.0072 0.0133
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0051 0.0093 0.0174
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.005 0.0092 0.0669
Plasmodium vivax thioredoxin reductase, putative 0.0049 0.0088 0.2943
Echinococcus granulosus inositol monophosphatase 1 0.0041 0.0066 0.0156
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0036 0.005 0.0167
Loa Loa (eye worm) kelch domain-containing protein family protein 0.0049 0.0089 0.0167
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0116 0.0283 0.0535
Echinococcus multilocularis Niemann Pick C1 protein 0.0105 0.0252 0.0252
Brugia malayi RNA, U transporter 1 0.0167 0.043 0.0813
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0051 0.0093 0.0093
Trypanosoma brucei DNA polymerase beta thumb, putative 0.013 0.0325 0.0613
Echinococcus multilocularis integrin beta 2 0.024 0.0644 0.0644
Brugia malayi latrophilin 2 splice variant baaae 0.014 0.0353 0.0666
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0036 0.005 0.0167
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0038 0.0055 0.307
Brugia malayi Integrin beta pat-3 precursor 0.0324 0.0888 0.1682
Echinococcus multilocularis pyruvate kinase 0.0053 0.01 0.01
Trichomonas vaginalis D-aminoacylase, putative 0.0107 0.0256 0.2932
Loa Loa (eye worm) pyruvate kinase 0.0067 0.0141 0.0265
Echinococcus multilocularis histone acetyltransferase MYST2 0.0116 0.0283 0.0283
Loa Loa (eye worm) hypothetical protein 0.014 0.0353 0.0666
Loa Loa (eye worm) hypothetical protein 0.0653 0.1842 0.3492
Mycobacterium tuberculosis Probable hydrolase 0.0107 0.0256 0.1251
Echinococcus multilocularis sterol regulatory element binding protein 0.0045 0.0078 0.0078
Loa Loa (eye worm) hypothetical protein 0.0038 0.0055 0.0103
Loa Loa (eye worm) glutaminase 0.0265 0.0714 0.1352
Loa Loa (eye worm) hypothetical protein 0.0046 0.008 0.015
Loa Loa (eye worm) hypothetical protein 0.0116 0.0283 0.0535
Echinococcus granulosus GPCR family 2 0.0065 0.0134 0.0317
Echinococcus multilocularis beta LACTamase domain containing family member 0.0107 0.0256 0.0256
Schistosoma mansoni myelin transcription factor 1 myt1 0.0116 0.0283 0.0792
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0038 0.0055 0.0199
Loa Loa (eye worm) pyruvate kinase 0.0067 0.0141 0.0265
Onchocerca volvulus Pyruvate kinase homolog 0.0067 0.0141 0.0492
Trichomonas vaginalis glutaminase, putative 0.0265 0.0714 1
Leishmania major 4-coumarate:coa ligase-like protein 0.005 0.0092 0.0173
Loa Loa (eye worm) hypothetical protein 0.0065 0.0134 0.0252
Schistosoma mansoni sex comb on midleg homolog 0.0102 0.0242 0.0678
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0111 0.0269 0.1317
Schistosoma mansoni tar DNA-binding protein 0.031 0.0846 0.2363
Echinococcus granulosus muscleblind protein 0.0146 0.037 0.0873
Loa Loa (eye worm) pyruvate kinase-PB 0.0047 0.0082 0.0153
Toxoplasma gondii LsmAD domain-containing protein 0.0081 0.0182 0.4528
Mycobacterium ulcerans acyl-CoA synthetase 0.005 0.0092 0.0669
Trichomonas vaginalis penicillin-binding protein, putative 0.0107 0.0256 0.2932
Onchocerca volvulus Vesicular acetylcholine transporter homolog 0.0995 0.2833 1
Echinococcus granulosus histone acetyltransferase MYST2 0.0116 0.0283 0.0669
Onchocerca volvulus 0.0107 0.0256 0.0899
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0096 0.0226 0.0633
Echinococcus granulosus integrin beta 2 0.024 0.0644 0.152
Trichomonas vaginalis D-aminoacylase, putative 0.0107 0.0256 0.2932
Toxoplasma gondii isocitrate dehydrogenase 0.0051 0.0093 0.208
Loa Loa (eye worm) bromodomain containing protein 0.0019 0.0002 0.0001
Onchocerca volvulus 0.0231 0.0618 0.2177
Brugia malayi Pre-SET motif family protein 0.0203 0.0537 0.1015
Mycobacterium leprae Probable lipase LipE 0.0107 0.0256 0.8303
Schistosoma mansoni inositol monophosphatase 0.0041 0.0066 0.0185
Brugia malayi hypothetical protein 0.0072 0.0157 0.0295
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0051 0.0093 0.0093
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0037 0.0054 0.0189
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0043 0.0072 0.2664
Schistosoma mansoni inositol monophosphatase 0.0041 0.0066 0.0185
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0682 0.1926 1
Echinococcus granulosus polycomb protein SCMH1 0.0102 0.0242 0.0572
Loa Loa (eye worm) hypothetical protein 0.0038 0.0055 0.0103
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0124 0.0305 0.1506
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0041 0.0066 0.0123
Leishmania major 4-coumarate:coa ligase-like protein 0.005 0.0092 0.0173
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0927 0.2636 0.4997
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0402 0.1113 0.1113
Echinococcus granulosus expressed conserved protein 0.0099 0.0234 0.0552
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0051 0.0093 0.0174
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0051 0.0093 0.0093
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0074 0.0161 0.0302
Brugia malayi beta-lactamase family protein 0.0107 0.0256 0.0484
Schistosoma mansoni tar DNA-binding protein 0.031 0.0846 0.2363
Brugia malayi MH2 domain containing protein 0.0244 0.0656 0.1242
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0043 0.0072 0.1488
Plasmodium falciparum pyruvate kinase 0.0067 0.0141 0.752
Schistosoma mansoni pyruvate kinase 0.0067 0.0141 0.0394
Schistosoma mansoni hypothetical protein 0.0022 0.0011 0.0031
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0041 0.0066 0.2075
Loa Loa (eye worm) hypothetical protein 0.1836 0.5273 1
Entamoeba histolytica hypothetical protein 0.0072 0.0157 0.593
Echinococcus multilocularis polycomb protein SCMH1 0.0102 0.0242 0.0242
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0074 0.0161 0.6096
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0031 0.0372
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0159 0.0407 0.077
Echinococcus granulosus zinc finger protein 0.0021 0.0008 0.0019
Brugia malayi Thioredoxin reductase 0.0049 0.0088 0.0164
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0043 0.0072 0.226
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0048 0.0084 0.0277
Onchocerca volvulus 0.005 0.0092 0.032
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0111 0.0269 0.1317
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0074 0.0161 0.0302
Entamoeba histolytica hypothetical protein 0.0072 0.0157 0.593
Loa Loa (eye worm) hypothetical protein 0.0107 0.0256 0.0484
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0051 0.0093 0.026
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0051 0.0093 0.0174
Brugia malayi glutathione reductase 0.0049 0.0088 0.0164
Schistosoma mansoni pyruvate kinase 0.0067 0.0141 0.0394
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.005 0.0092 0.0669
Plasmodium vivax pyruvate kinase, putative 0.0067 0.0141 0.5172
Echinococcus multilocularis protein patched 0.0045 0.0078 0.0078
Toxoplasma gondii pyruvate kinase PyKII 0.0034 0.0046 0.0792
Leishmania major phosphopantetheinyl transferase-like protein 0.0025 0.0018 0.0031
Echinococcus granulosus pyruvate kinase 0.0034 0.0046 0.0109
Trypanosoma cruzi C-8 sterol isomerase, putative 0.1836 0.5273 1
Schistosoma mansoni bromodomain containing protein 0.0069 0.0145 0.0406
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0048 0.0084 0.0277
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0107 0.0256 0.0484
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0107 0.0256 0.1251
Entamoeba histolytica acyl-coA synthetase, putative 0.005 0.0092 0.3187
Loa Loa (eye worm) glutathione reductase 0.0049 0.0088 0.0164
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0041 0.0066 0.0123
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0189 0.0496 0.1745
Entamoeba histolytica hypothetical protein 0.0072 0.0157 0.593
Schistosoma mansoni hypothetical protein 0.014 0.0353 0.0985
Trichomonas vaginalis pyruvate kinase, putative 0.0067 0.0141 0.1153
Echinococcus multilocularis protein dispatched 1 0.0052 0.0096 0.0096
Plasmodium vivax importin-beta 2, putative 0.0059 0.0116 0.4141
Brugia malayi Calcitonin receptor-like protein seb-1 0.0205 0.054 0.1023
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0065 0.0134 0.0317
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0065 0.0134 0.0316
Echinococcus granulosus Niemann Pick C1 protein 0.0151 0.0384 0.0905
Echinococcus multilocularis tar DNA binding protein 0.031 0.0846 0.0846
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0087 0.02 0.0376
Trichomonas vaginalis esterase, putative 0.0107 0.0256 0.2932
Brugia malayi Pre-SET motif family protein 0.0029 0.0031 0.0056
Mycobacterium tuberculosis Conserved protein 0.0107 0.0256 0.1251
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.005 0.0092 0.2603
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0096 0.0226 0.0633
Loa Loa (eye worm) hypothetical protein 0.0107 0.0256 0.0484
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0043 0.0072 0.0133
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0028 0.0066
Plasmodium vivax acyl-CoA synthetase, putative 0.0038 0.0055 0.1588
Mycobacterium ulcerans lipase LipD 0.0107 0.0256 0.1872
Onchocerca volvulus 0.0102 0.0242 0.085
Brugia malayi Bromodomain containing protein 0.0041 0.0067 0.0124
Mycobacterium tuberculosis Conserved protein 0.0107 0.0256 0.1251
Brugia malayi glutaminase DH11.1 0.0265 0.0714 0.1352
Schistosoma mansoni integrin beta subunit 0.0191 0.0501 0.14
Schistosoma mansoni hypothetical protein 0.0065 0.0134 0.0376
Mycobacterium ulcerans acyl-CoA synthetase 0.005 0.0092 0.0669
Brugia malayi Latrophilin receptor protein 2 0.0065 0.0134 0.0252
Brugia malayi beta-lactamase family protein 0.0107 0.0256 0.0484
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0078 0.0176
Trypanosoma brucei importin beta-1 subunit, putative 0.0059 0.0116 0.0218
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0051 0.0093 0.0174
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0036 0.0052 0.0123
Echinococcus multilocularis pyruvate kinase 0.0067 0.0141 0.0141
Schistosoma mansoni tar DNA-binding protein 0.031 0.0846 0.2363
Onchocerca volvulus Huntingtin homolog 0.0137 0.0344 0.1209
Mycobacterium ulcerans acyl-CoA synthetase 0.005 0.0092 0.0669
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0036 0.0052 0.0052
Schistosoma mansoni zinc finger protein 0.0021 0.0008 0.0022
Loa Loa (eye worm) hypothetical protein 0.005 0.0092 0.0173
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0107 0.0257 0.0718
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0025 0.0018 0.5
Trypanosoma brucei importin beta-1 subunit, putative 0.0059 0.0116 0.0218
Schistosoma mansoni vesicular acetylcholine transporter 0.0995 0.2833 0.7917
Brugia malayi vesicular acetylcholine transporter unc-17 0.0995 0.2833 0.5371
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0074 0.0161 0.0302
Echinococcus multilocularis SAM and MBT domain containing protein 0.0102 0.0242 0.0242
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0096 0.0226 0.0534
Echinococcus multilocularis muscleblind protein 0.0146 0.037 0.037
Schistosoma mansoni hypothetical protein 0.0044 0.0073 0.0204
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0041 0.0066 0.1343
Entamoeba histolytica pyruvate kinase, putative 0.0047 0.0082 0.275
Trypanosoma cruzi importin beta-1 subunit, putative 0.0048 0.0084 0.0157
Brugia malayi hypothetical protein 0.0049 0.0089 0.0167
Trypanosoma brucei trypanothione reductase 0.0049 0.0088 0.0164
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0038 0.0055 0.0398
Plasmodium vivax hypothetical protein, conserved 0.0107 0.0256 1
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0439 0.1219 0.231
Trypanosoma cruzi hypothetical protein, conserved 0.0107 0.0256 0.0484
Echinococcus granulosus Protein patched homolog 1 0.0045 0.0078 0.0183
Schistosoma mansoni hypothetical protein 0.0065 0.0134 0.0376
Brugia malayi RNA recognition motif domain containing protein 0.031 0.0846 0.1602
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0439 0.1219 0.231
Echinococcus multilocularis pyruvate kinase 0.0067 0.0141 0.0141
Echinococcus granulosus SAM and MBT domain containing protein 0.0102 0.0242 0.0572
Leishmania major trypanothione reductase 0.0049 0.0088 0.0164
Trypanosoma brucei hypothetical protein, conserved 0.0025 0.0018 0.0031
Trichomonas vaginalis penicillin-binding protein, putative 0.0107 0.0256 0.2932
Entamoeba histolytica acyl-CoA synthetase, putative 0.005 0.0092 0.3187
Onchocerca volvulus 0.0029 0.0031 0.0103
Schistosoma mansoni glutaminase 0.0265 0.0714 0.1996
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0096 0.0226 0.0633
Brugia malayi Muscleblind-like protein 0.0146 0.037 0.0699
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0051 0.0093 0.0174
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0927 0.2636 0.4997
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0045 0.0078 0.0145
Loa Loa (eye worm) hypothetical protein 0.0087 0.02 0.0376
Mycobacterium leprae conserved hypothetical protein 0.0107 0.0256 0.8303
Loa Loa (eye worm) beta-lactamase 0.0107 0.0256 0.0484
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0439 0.1219 0.231
Schistosoma mansoni hypothetical protein 0.0044 0.0073 0.0204
Schistosoma mansoni hypothetical protein 0.1252 0.3578 1
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.013 0.0325 0.0613
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0102 0.0242 0.085
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0205 0.054 0.1023
Brugia malayi PHD-finger family protein 0.0027 0.0025 0.0044
Echinococcus multilocularis pyruvate kinase 0.0034 0.0046 0.0046
Onchocerca volvulus 0.0087 0.02 0.0698
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0096 0.0226 0.0226
Loa Loa (eye worm) vesicular acetylcholine transporter unc-17 0.0995 0.2833 0.5371
Plasmodium falciparum ataxin-2 like protein, putative 0.0081 0.0182 1
Loa Loa (eye worm) hypothetical protein 0.0107 0.0256 0.0484
Echinococcus granulosus histone lysine methyltransferase setb 0.0048 0.0085 0.02
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0096 0.0226 0.0427
Brugia malayi AMP-binding enzyme family protein 0.005 0.0092 0.0173
Trypanosoma cruzi hypothetical protein, conserved 0.0107 0.0256 0.0484
Brugia malayi CHE-14 protein 0.0045 0.0078 0.0145
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0074 0.0161 0.0302
Loa Loa (eye worm) RNA binding protein 0.031 0.0846 0.1602
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0107 0.0256 0.1872
Loa Loa (eye worm) hypothetical protein 0.0146 0.037 0.0699
Echinococcus multilocularis transcription factor Dp 1 0.0043 0.007 0.007
Brugia malayi hypothetical protein 0.0653 0.1842 0.3492
Schistosoma mansoni ran 0.0043 0.0072 0.02
Loa Loa (eye worm) hypothetical protein 0.005 0.0092 0.0173
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0043 0.0072 0.0133
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0116 0.0283 0.0283
Schistosoma mansoni hypothetical protein 0.0044 0.0073 0.0204
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0051 0.0093 0.0219
Brugia malayi Cytochrome P450 family protein 0.0048 0.0085 0.0158
Mycobacterium ulcerans hypothetical protein 0.005 0.0092 0.0669
Loa Loa (eye worm) transcription factor SMAD2 0.0244 0.0656 0.1242
Mycobacterium ulcerans hypothetical protein 0.0488 0.1363 1
Mycobacterium ulcerans fatty-acid-CoA ligase 0.005 0.0092 0.0669
Brugia malayi beta-lactamase 0.0107 0.0256 0.0484
Loa Loa (eye worm) hypothetical protein 0.0059 0.0116 0.0218
Echinococcus multilocularis microtubule associated protein 2 0.0674 0.1903 0.1903
Leishmania major C-8 sterol isomerase-like protein 0.1836 0.5273 1
Loa Loa (eye worm) thioredoxin reductase 0.0049 0.0088 0.0164
Entamoeba histolytica acyl-CoA synthetase, putative 0.005 0.0092 0.3187
Mycobacterium ulcerans hypothetical protein 0.0107 0.0256 0.1872
Mycobacterium ulcerans pyruvate kinase 0.0067 0.0141 0.1026
Echinococcus granulosus pyruvate kinase 0.0034 0.0046 0.0109
Schistosoma mansoni hypothetical protein 0.0036 0.0052 0.0145
Echinococcus multilocularis expressed conserved protein 0.0099 0.0234 0.0234

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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