Detailed information for compound 801189

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 471.543 | Formula: C26H33NO7
  • H donors: 2 H acceptors: 4 LogP: 4.03 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOc1cc(ccc1O)C1C(=C(C)N=C2C1=C(O)C(C(C2)C)C(=O)OC)C(=O)OC(CC)C
  • InChi: 1S/C26H33NO7/c1-7-14(4)34-26(31)21-15(5)27-17-11-13(3)20(25(30)32-6)24(29)23(17)22(21)16-9-10-18(28)19(12-16)33-8-2/h9-10,12-14,20,22,28-29H,7-8,11H2,1-6H3
  • InChiKey: VJTDXLDFXVLRFL-UHFFFAOYSA-N  


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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0049 0.0088
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0021 0.0206 0.1246
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.0203 0.2787 1
Loa Loa (eye worm) hypothetical protein 0.0072 0.0929 0.1673
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0049 0.0088
Loa Loa (eye worm) hypothetical protein 0.0065 0.0829 0.1492
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0021 0.0206 0.0371
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0049 0.0049
Trypanosoma cruzi hypothetical protein, conserved 0.0012 0.0077 0.0139
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0049 0.0088
Echinococcus multilocularis SWI:SNF matrix associated 0.0203 0.2787 0.2787
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0092 0.0092
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0179 1
Schistosoma mansoni aldehyde dehydrogenase 0.0123 0.1656 0.1656
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0021 0.0206 0.0371
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0021 0.0206 0.1246
Schistosoma mansoni lamin 0.0028 0.0295 0.0295
Brugia malayi YY1-associated factor 2 0.0072 0.0929 0.1673
Trypanosoma cruzi Zn-finger in Ran binding protein and others, putative 0.0072 0.0929 0.1673
Loa Loa (eye worm) hypothetical protein 0.003 0.0325 0.0586
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0113 0.0204
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.0337 0.0337
Brugia malayi SWIB/MDM2 domain containing protein 0.0203 0.2787 0.5017
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0206 0.1246
Onchocerca volvulus Bile acid receptor homolog 0.001 0.0049 0.0146
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0021 0.0206 0.0206
Trypanosoma cruzi WLM domain containing protein, putative 0.0072 0.0929 0.1673
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0206 0.0371
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0206 0.1246
Schistosoma mansoni hypothetical protein 0.0173 0.2361 0.2361
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0021 0.0206 0.1246
Trichomonas vaginalis antibiotic synthetase, putative 0.0021 0.0206 0.0618
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0049 0.0088
Onchocerca volvulus 0.0072 0.0929 0.2782
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0039 0.0463 0.2796
Toxoplasma gondii DNA topoisomerase domain-containing protein 0.0203 0.2787 1
Schistosoma mansoni zinc finger protein 0.0072 0.0929 0.0929
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0123 0.1656 1
Echinococcus granulosus FTZ F1 alpha 0.001 0.0049 0.0049
Schistosoma mansoni lamin 0.0028 0.0295 0.0295
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0021 0.0206 0.1246
Loa Loa (eye worm) hypothetical protein 0.0154 0.2089 0.3761
Leishmania major 4-coumarate:coa ligase-like protein 0.0073 0.0935 0.1683
Trypanosoma brucei hypothetical protein, conserved 0.0072 0.0929 0.1673
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0021 0.0206 0.074
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0463 0.0834
Schistosoma mansoni acetyl-CoA synthetase 0.0021 0.0206 0.0206
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0073 0.0935 0.5644
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0325 0.0586
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0049 0.0088
Onchocerca volvulus 0.0072 0.0929 0.2782
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0179 0.0322
Trypanosoma brucei mitochondrial RNA binding complex 1 subunit 0.0072 0.0929 0.1673
Mycobacterium ulcerans aldehyde dehydrogenase 0.0123 0.1656 1
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0206 0.0371
Loa Loa (eye worm) hypothetical protein 0.0154 0.2089 0.3761
Loa Loa (eye worm) hypothetical protein 0.0073 0.0935 0.1683
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0049 0.0049
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.0289 0.0521
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0179 0.0535
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0021 0.0206 0.1246
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0049 0.0049
Trypanosoma cruzi 3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative 0.0149 0.2014 0.3627
Schistosoma mansoni fusion 0.0072 0.0929 0.0929
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0567 0.0567
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0246 0.0442
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.0463 0.0834
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0021 0.0206 0.1246
Echinococcus multilocularis Zinc finger, RanBP2 type 0.0072 0.0929 0.0929
Toxoplasma gondii SWIB/MDM2 domain-containing protein 0.0203 0.2787 1
Echinococcus granulosus Zinc finger RanBP2 type 0.0072 0.0929 0.0929
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0049 0.0088
Echinococcus multilocularis SWI:SNF matrix associated 0.0203 0.2787 0.2787
Trypanosoma brucei DNA polymerase IV, putative 0.0039 0.0463 0.0834
Schistosoma mansoni hypothetical protein 0.0072 0.0929 0.0929
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0123 0.1656 0.2982
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0463 0.0834
Loa Loa (eye worm) oxidoreductase 0.0021 0.0206 0.0371
Brugia malayi AMP-binding enzyme family protein 0.0073 0.0935 0.1683
Onchocerca volvulus Ubiquitin thioesterase ZRANB1 homolog 0.0072 0.0929 0.2782
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0206 0.0371
Loa Loa (eye worm) hypothetical protein 0.0013 0.0085 0.0153
Leishmania major 4-coumarate:coa ligase-like protein 0.0073 0.0935 0.1683
Loa Loa (eye worm) hypothetical protein 0.0012 0.0077 0.0139
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0246 0.0736
Mycobacterium ulcerans acyl-CoA synthetase 0.0073 0.0935 0.5644
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0021 0.0206 0.1246
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0179 0.0322
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0049 0.0088
Onchocerca volvulus 0.0072 0.0929 0.2782
Onchocerca volvulus Protein ultraspiracle homolog 0.001 0.0049 0.0146
Echinococcus granulosus snurportin 1 0.0317 0.4407 0.4407
Echinococcus multilocularis dna polymerase eta 0.0065 0.0829 0.0829
Trypanosoma cruzi 3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative 0.0149 0.2014 0.3627
Onchocerca volvulus 0.001 0.0049 0.0146
Schistosoma mansoni aldehyde dehydrogenase 0.0123 0.1656 0.1656
Echinococcus multilocularis lamin dm0 0.0028 0.0295 0.0295
Loa Loa (eye worm) hypothetical protein 0.0072 0.0929 0.1673
Trypanosoma cruzi Zn-finger in Ran binding protein and others, putative 0.0072 0.0929 0.1673
Trypanosoma brucei C-8 sterol isomerase, putative 0.0398 0.5554 1
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0179 0.0179
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0049 0.0049
Echinococcus multilocularis zinc finger protein Ran binding 0.0072 0.0929 0.0929
Trichomonas vaginalis antibiotic synthetase, putative 0.0021 0.0206 0.0618
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0206 0.1246
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0179 0.0535
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.001 0.0049 0.0146
Echinococcus multilocularis lamin 0.0028 0.0295 0.0295
Leishmania major 4-coumarate:coa ligase-like protein 0.0073 0.0935 0.1683
Toxoplasma gondii HEAT repeat-containing protein 0.003 0.0325 0.1168
Schistosoma mansoni importin beta-1 0.003 0.0325 0.0325
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0049 0.0049
Mycobacterium leprae POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) 0.0021 0.0206 0.2207
Loa Loa (eye worm) hypothetical protein 0.0021 0.0206 0.0371
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0021 0.0206 0.0371
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0021 0.0206 0.1246
Loa Loa (eye worm) hypothetical protein 0.0021 0.0206 0.0371
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0463 0.0834
Leishmania major hypothetical protein, conserved 0.0072 0.0929 0.1673
Trypanosoma brucei DNA polymerase eta, putative 0.0065 0.0829 0.1492
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0325 0.0586
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0179 0.0179
Leishmania major acetyl-CoA synthetase, putative 0.0021 0.0206 0.0371
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0018 0.0164 0.0992
Echinococcus granulosus intermediate filament protein 0.0028 0.0295 0.0295
Leishmania major DNA polymerase kappa, putative 0.0039 0.0463 0.0834
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0567 0.0567
Plasmodium falciparum zinc finger Ran-binding domain-containing protein 2, putative 0.0072 0.0929 0.3144
Trypanosoma cruzi pantothenate kinase subunit, putative 0.0007 0.0001 0.0002
Mycobacterium ulcerans DNA polymerase IV 0.0039 0.0463 0.2796
Brugia malayi AMP-binding enzyme family protein 0.0073 0.0935 0.1683
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0049 0.0049
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0179 0.0322
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0049 0.0088
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0049 0.0049
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0021 0.0206 0.0477
Schistosoma mansoni terminal deoxycytidyl transferase 0.0039 0.0463 0.0463
Brugia malayi ERG2 and Sigma1 receptor like protein 0.0398 0.5554 1
Leishmania major DNA polymerase eta, putative 0.0038 0.0443 0.0797
Trypanosoma cruzi DNA polymerase eta, putative 0.0065 0.0829 0.1492
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0072 0.0929 0.1673
Trypanosoma brucei unspecified product 0.0027 0.0289 0.0521
Chlamydia trachomatis DNA topoisomerase I 0.0203 0.2787 1
Echinococcus multilocularis dna polymerase kappa 0.0039 0.0463 0.0463
Echinococcus granulosus dna polymerase kappa 0.0039 0.0463 0.0463
Trypanosoma brucei unspecified product 0.0027 0.0289 0.0521
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0206 0.1246
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0021 0.0206 0.0371
Leishmania major DNA polymerase eta, putative 0.0065 0.0829 0.1492
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0021 0.0206 0.0371
Brugia malayi Pre-SET motif family protein 0.0213 0.2922 0.5261
Leishmania major hypothetical protein, conserved 0.0072 0.0929 0.1673
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0179 1
Onchocerca volvulus 0.0073 0.0935 0.2799
Mycobacterium ulcerans acyl-CoA synthetase 0.0073 0.0935 0.5644
Entamoeba histolytica hypothetical protein 0.0024 0.0246 0.2628
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0021 0.0206 0.0371
Entamoeba histolytica acyl-CoA synthetase, putative 0.0073 0.0935 1
Toxoplasma gondii aldehyde dehydrogenase 0.0123 0.1656 0.5943
Giardia lamblia DINP protein human, muc B family 0.0039 0.0463 1
Schistosoma mansoni DNA polymerase IV / kappa 0.0012 0.0077 0.0077
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.0463 0.0834
Echinococcus multilocularis importin subunit beta 1 0.003 0.0325 0.0325
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0049 0.0049
Trypanosoma cruzi mitochondrial RNA binding complex 1 subunit, putative 0.0072 0.0929 0.1673
Brugia malayi ImpB/MucB/SamB family protein 0.0065 0.0829 0.1492
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0051 0.0632 0.3816
Trypanosoma brucei hypothetical protein, conserved 0.0072 0.0929 0.1673
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0049 0.0049
Loa Loa (eye worm) hypothetical protein 0.0031 0.0337 0.0606
Brugia malayi steroid hormone receptor 0.001 0.0049 0.0088
Trypanosoma brucei DNA damage repair protein, putative 0.0012 0.0077 0.0139
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0337 0.0337
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0073 0.0935 0.5644
Loa Loa (eye worm) SWIB/MDM2 domain-containing protein 0.0203 0.2787 0.5017
Loa Loa (eye worm) hypothetical protein 0.0073 0.0935 0.1683
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0463 0.0834
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0021 0.0206 0.1246
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0049 0.0088
Brugia malayi brahma associated protein 60 kDa 0.0203 0.2787 0.5017
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0049 0.0088
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0049 0.0049
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0049 0.0088
Onchocerca volvulus 0.0028 0.0295 0.0883
Echinococcus multilocularis SWI:SNF matrix associated 0.0203 0.2787 0.2787
Onchocerca volvulus 0.0031 0.0337 0.1008
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0567 0.0567
Onchocerca volvulus 0.0149 0.2014 0.6032
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0073 0.0935 0.5644
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0206 0.1246
Plasmodium vivax SET domain protein, putative 0.0031 0.0337 0.0957
Trypanosoma brucei Emopamil binding protein, putative 0.0149 0.2014 0.3627
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0337 0.0337
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0179 0.0375
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0049 0.0049
Trypanosoma cruzi hypothetical protein, conserved 0.0012 0.0077 0.0139
Echinococcus granulosus muscleblind protein 0.0154 0.2089 0.2089
Loa Loa (eye worm) hypothetical protein 0.0013 0.0092 0.0166
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0021 0.0206 0.2207
Brugia malayi nuclear hormone receptor 0.001 0.0049 0.0088
Schistosoma mansoni thyroid hormone receptor 0.001 0.0049 0.0049
Schistosoma mansoni nuclear hormone receptor 0.001 0.0049 0.0049
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0021 0.0206 0.0206
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0246 0.0736
Loa Loa (eye worm) hypothetical protein 0.0239 0.3298 0.5939
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0398 0.5554 1
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0049 0.0088
Trypanosoma brucei DNA polymerase kappa, putative 0.0012 0.0077 0.0139
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0179 0.386
Loa Loa (eye worm) hypothetical protein 0.001 0.0049 0.0088
Brugia malayi intermediate filament protein 0.0028 0.0295 0.0531
Loa Loa (eye worm) hypothetical protein 0.0028 0.0295 0.0531
Mycobacterium ulcerans acetyl-CoA synthetase 0.0021 0.0206 0.1246
Brugia malayi ecdysteroid receptor 0.001 0.0049 0.0088
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0206 0.1246
Loa Loa (eye worm) hypothetical protein 0.001 0.0049 0.0088
Loa Loa (eye worm) hypothetical protein 0.0072 0.0929 0.1673
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.0289 0.0521
Schistosoma mansoni thyroid hormone receptor 0.001 0.0049 0.0049
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0463 0.0834
Mycobacterium ulcerans aldehyde dehydrogenase 0.0123 0.1656 1
Trypanosoma cruzi DNA damage repair protein, putative 0.0012 0.0077 0.0139
Echinococcus granulosus ring and YY1 binding protein 0.0072 0.0929 0.0929
Loa Loa (eye worm) brahma associated protein 0.0203 0.2787 0.5017
Echinococcus multilocularis muscleblind protein 0.0154 0.2089 0.2089
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0123 0.1656 0.1656
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.0337 0.0337
Echinococcus granulosus geminin 0.0173 0.2361 0.2361
Loa Loa (eye worm) hypothetical protein 0.0398 0.5554 1
Echinococcus granulosus survival motor neuron protein 1 0.0239 0.3298 0.3298
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0049 0.0049
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0337 0.0337
Echinococcus multilocularis ring and YY1 binding protein 0.0072 0.0929 0.0929
Mycobacterium tuberculosis Conserved hypothetical protein 0.0039 0.0463 0.2796
Plasmodium vivax importin-beta 2, putative 0.003 0.0325 0.0916
Leishmania major pantothenate kinase subunit, putative 0.0007 0.0001 0.0002
Trypanosoma cruzi Emopamil binding protein, putative 0.0149 0.2014 0.3627
Echinococcus granulosus importin subunit beta 1 0.003 0.0325 0.0325
Onchocerca volvulus 0.0021 0.0206 0.0618
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0012 0.0077 0.0277
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0049 0.0049
Plasmodium vivax hypothetical protein, conserved 0.0203 0.2787 1
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0179 0.1912
Onchocerca volvulus 0.0049 0.0596 0.1785
Leishmania major hypothetical protein, conserved 0.0149 0.2014 0.3627
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0049 0.0088
Plasmodium vivax acyl-CoA synthetase, putative 0.0054 0.0674 0.2203
Echinococcus multilocularis musashi 0.0028 0.0295 0.0295
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0179 0.0322
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0051 0.0632 0.3816
Trypanosoma cruzi hypothetical protein, conserved 0.0072 0.0929 0.1673
Giardia lamblia DNA damage repair protein 0.0012 0.0077 0.1667
Echinococcus granulosus lamin dm0 0.0028 0.0295 0.0295
Brugia malayi hypothetical protein 0.0239 0.3298 0.5939
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0051 0.0632 0.3816
Toxoplasma gondii Zn-finger in Ran binding protein and others domain-containing protein 0.0072 0.0929 0.3334
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0049 0.0088
Mycobacterium ulcerans hypothetical protein 0.0073 0.0935 0.5644
Trypanosoma cruzi Emopamil binding protein, putative 0.0149 0.2014 0.3627
Echinococcus granulosus SWI:SNF matrix associated 0.0203 0.2787 0.2787
Leishmania major DNA polymerase kappa, putative 0.0012 0.0077 0.0139
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0073 0.0935 1
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0039 0.0463 0.1386
Onchocerca volvulus 0.0028 0.0295 0.0883
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0049 0.0049
Onchocerca volvulus 0.0072 0.0929 0.2782
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0567 0.0567
Trypanosoma brucei DNA polymerase kappa, putative 0.0012 0.0077 0.0139
Schistosoma mansoni hypothetical protein 0.0173 0.2361 0.2361
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0463 0.0834
Loa Loa (eye worm) hypothetical protein 0.001 0.0049 0.0088
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0021 0.0206 0.0371
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0021 0.0206 0.0371
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0049 0.0088
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0072 0.0929 0.1673
Loa Loa (eye worm) hypothetical protein 0.0072 0.0929 0.1673
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0039 0.0463 0.0463
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0179 0.1079
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0049 0.0049
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0321 0.0321
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0039 0.0463 0.0463
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0049 0.0088
Leishmania major hypothetical protein, conserved 0.0072 0.0929 0.1673
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0049 0.0596 0.1073
Echinococcus multilocularis Upstream activation factor subunit UAF30 0.0203 0.2787 0.2787
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0021 0.0206 0.0371
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0049 0.0088
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.0463 0.0834
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0021 0.0206 0.0371
Onchocerca volvulus 0.0203 0.2787 0.8345
Entamoeba histolytica deoxycytidyl transferase, putative 0.0039 0.0463 0.4953
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.0463 0.0834
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0047 0.0567 0.1021
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0049 0.0049
Onchocerca volvulus 0.0242 0.3339 1
Loa Loa (eye worm) hypothetical protein 0.0073 0.0935 0.1683
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0206 0.1246
Loa Loa (eye worm) hypothetical protein 0.0054 0.0674 0.1214
Trypanosoma brucei DNA polymerase IV, putative 0.0039 0.0463 0.0834
Echinococcus multilocularis muscleblind protein 1 0.0154 0.2089 0.2089
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0206 0.1246
Entamoeba histolytica acyl-CoA synthetase, putative 0.0073 0.0935 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0047 0.0567 0.1021
Leishmania major C-8 sterol isomerase-like protein 0.0398 0.5554 1
Leishmania major acetyl-CoA synthetase, putative 0.0021 0.0206 0.0371
Trypanosoma brucei DNA polymerase IV, putative 0.0039 0.0463 0.0834
Loa Loa (eye worm) hypothetical protein 0.0203 0.2792 0.5026
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0567 0.0567
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0213 0.2922 0.5261
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0463 0.0834
Leishmania major DNA damage repair protein, putative 0.0012 0.0077 0.0139
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0049 0.0088
Plasmodium falciparum importin beta, putative 0.003 0.0325 0.0916
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0021 0.0206 0.0371
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0054 0.0674 0.407
Trypanosoma brucei hypothetical protein, conserved 0.0012 0.0077 0.0139
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0012 0.0077 0.0277
Loa Loa (eye worm) hypothetical protein 0.001 0.0049 0.0088
Echinococcus granulosus dna polymerase eta 0.0065 0.0829 0.0829
Echinococcus granulosus Upstream activation factor subunit UAF30 0.0203 0.2787 0.2787
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0049 0.0049
Toxoplasma gondii ran binding protein 0.0072 0.0929 0.3334
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0206 0.1246
Schistosoma mansoni DNA polymerase eta 0.0065 0.0829 0.0829
Plasmodium falciparum acyl-CoA synthetase 0.0054 0.0674 0.2203
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0463 0.0834
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0092 0.0092
Trypanosoma cruzi Zn-finger in Ran binding protein and others/FYVE zinc finger, putative 0.0072 0.0929 0.1673
Echinococcus granulosus lamin 0.0028 0.0295 0.0295
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.0203 0.2787 1
Trichomonas vaginalis set domain proteins, putative 0.0242 0.3339 1
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0021 0.0206 0.1246
Brugia malayi AMP-binding enzyme family protein 0.0073 0.0935 0.1683
Trypanosoma brucei hypothetical protein, conserved 0.0012 0.0077 0.0139
Loa Loa (eye worm) hypothetical protein 0.001 0.0049 0.0088
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0206 0.1246
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0039 0.0463 0.0834
Trypanosoma cruzi DNA polymerase eta, putative 0.0038 0.0443 0.0797
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0179 0.0322
Mycobacterium leprae POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0021 0.0206 0.2207
Loa Loa (eye worm) hypothetical protein 0.0054 0.0674 0.1214
Trypanosoma cruzi DNA damage repair protein, putative 0.0012 0.0077 0.0139
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0463 0.0834
Schistosoma mansoni ap endonuclease 0.0019 0.0179 0.0179
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0317 0.4407 0.7935
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0049 0.0088
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0049 0.0088
Entamoeba histolytica acyl-coA synthetase, putative 0.0073 0.0935 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0567 0.0567
Trypanosoma cruzi hypothetical protein, conserved 0.0072 0.0929 0.1673
Onchocerca volvulus 0.0021 0.0206 0.0618
Trypanosoma cruzi WLM domain containing protein, putative 0.0072 0.0929 0.1673
Brugia malayi brahma associated protein 60 kDa 0.0203 0.2787 0.5017
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.0289 0.0521
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0073 0.0935 1
Schistosoma mansoni ap endonuclease 0.0019 0.0179 0.0179
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0179 0.0375
Schistosoma mansoni survival motor neuron protein 0.0049 0.0596 0.0596
Schistosoma mansoni hypothetical protein 0.0203 0.2787 0.2787
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0021 0.0206 0.074
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0179 0.1079
Echinococcus granulosus Nuclear pore complex protein Nup153 0.0072 0.0929 0.0929
Trypanosoma brucei unspecified product 0.0039 0.0463 0.0834
Loa Loa (eye worm) hypothetical protein 0.0027 0.0288 0.0518
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0073 0.0935 0.5644
Echinococcus multilocularis microtubule associated protein 2 0.0711 1 1
Mycobacterium ulcerans DNA polymerase IV 0.0039 0.0463 0.2796
Schistosoma mansoni RNA binding protein 0.0072 0.0929 0.0929
Echinococcus multilocularis Nuclear pore complex protein Nup153 0.0072 0.0929 0.0929
Mycobacterium ulcerans acyl-CoA synthetase 0.0073 0.0935 0.5644
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0295 0.0531
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0337 0.0337
Trypanosoma brucei Zn-finger in Ran binding protein and others/FYVE zinc finger, putative 0.0072 0.0929 0.1673
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0049 0.0049
Leishmania major hypothetical protein, conserved 0.0072 0.0929 0.1673
Leishmania major hypothetical protein, conserved 0.0072 0.0929 0.1673
Trypanosoma cruzi mitochondrial RNA binding complex 1 subunit, putative 0.0072 0.0929 0.1673
Loa Loa (eye worm) hypothetical protein 0.0013 0.0085 0.0153
Loa Loa (eye worm) hypothetical protein 0.0054 0.0674 0.1214
Brugia malayi Pre-SET motif family protein 0.0031 0.0337 0.0606
Schistosoma mansoni intermediate filament proteins 0.0028 0.0295 0.0295
Schistosoma mansoni hypothetical protein 0.0203 0.2787 0.2787
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0072 0.0929 0.1673
Trypanosoma brucei DNA damage repair protein, putative 0.0012 0.0077 0.0139
Loa Loa (eye worm) hypothetical protein 0.0072 0.0929 0.1673
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0073 0.0935 0.5644
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0049 0.0049
Trypanosoma brucei chrX additional, unordered contigs 0.0012 0.0077 0.0139
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0049 0.0088
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0463 0.0834
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0113 0.0204
Echinococcus multilocularis survival motor neuron protein 1 0.0239 0.3298 0.3298
Loa Loa (eye worm) hypothetical protein 0.001 0.0049 0.0088
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0337 0.0337
Trichomonas vaginalis conserved hypothetical protein 0.0203 0.2787 0.8345
Chlamydia trachomatis SWIB complex protein 0.0203 0.2787 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0049 0.0088
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0123 0.1656 0.1656
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0054 0.0674 0.407
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0049 0.0049
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0021 0.0206 0.1246
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0049 0.0049
Plasmodium vivax acetyl-CoA synthetase, putative 0.0021 0.0206 0.0477
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0049 0.0049
Loa Loa (eye worm) hypothetical protein 0.0054 0.0674 0.1214
Schistosoma mansoni brg-1 associated factor 0.0203 0.2787 0.2787
Brugia malayi nuclear receptor NHR-88 0.001 0.0049 0.0088
Schistosoma mansoni hypothetical protein 0.0203 0.2787 0.2787
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0073 0.0935 0.5644
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0051 0.0632 0.3816
Schistosoma mansoni hypothetical protein 0.0049 0.0596 0.0596
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0021 0.0206 0.1246
Brugia malayi ImpB/MucB/SamB family protein 0.0039 0.0463 0.0834
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0038 0.0443 0.1589
Toxoplasma gondii propionate-CoA ligase 0.0021 0.0206 0.074
Schistosoma mansoni coup transcription factor 0.001 0.0049 0.0049
Brugia malayi Muscleblind-like protein 0.0154 0.2089 0.3761
Schistosoma mansoni hypothetical protein 0.0317 0.4407 0.4407
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0567 0.0567
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0049 0.0088
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0295 0.0531
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0337 0.1208
Leishmania major 3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative 0.0149 0.2014 0.3627
Echinococcus multilocularis snurportin 1 0.0317 0.4407 0.4407
Schistosoma mansoni microtubule-associated protein tau 0.0711 1 1
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0021 0.0206 0.1246
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0039 0.0463 0.0834
Trypanosoma cruzi hypothetical protein, conserved 0.0072 0.0929 0.1673
Echinococcus granulosus zinc finger protein Ran binding 0.0072 0.0929 0.0929
Loa Loa (eye worm) hypothetical protein 0.001 0.0049 0.0088
Mycobacterium ulcerans aldehyde dehydrogenase 0.0123 0.1656 1
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0021 0.0206 0.2207
Brugia malayi Importin beta-1 subunit 0.003 0.0325 0.0586
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0049 0.0088
Plasmodium vivax SWIB/MDM2 domain-containing protein, putative 0.0203 0.2787 1
Onchocerca volvulus 0.0021 0.0206 0.0618
Echinococcus multilocularis geminin 0.0173 0.2361 0.2361
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0072 0.0929 0.1673
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0179 0.0322
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0049 0.0049
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0206 0.1246
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0039 0.0463 0.0463
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0021 0.0206 0.1246
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0049 0.0049
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0049 0.0049
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0206 0.1246
Leishmania major importin beta-1 subunit, putative 0.0024 0.0246 0.0442
Trichomonas vaginalis DNA polymerase eta, putative 0.0039 0.0463 0.1386
Brugia malayi RNA, U transporter 1 0.0085 0.1103 0.1986
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0021 0.0206 0.1246
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0049 0.0088
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0206 0.0371
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0295 0.0531
Brugia malayi polk-prov protein 0.0012 0.0077 0.0139
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0049 0.0049
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0246 0.0736
Loa Loa (eye worm) hypothetical protein 0.0054 0.0674 0.1214
Mycobacterium ulcerans hypothetical protein 0.0012 0.0077 0.0466
Schistosoma mansoni TRABID protein (C64 family) 0.0072 0.0929 0.0929
Onchocerca volvulus 0.0021 0.0206 0.0618
Toxoplasma gondii exonuclease III APE 0.0019 0.0179 0.0641

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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