Detailed information for compound 801312

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 473.516 | Formula: C25H31NO8
  • H donors: 2 H acceptors: 4 LogP: 2.85 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: COC(=O)C1C(C)CC2=C(C1=O)C(c1cc(OC)c(c(c1)OC)O)/C(=C(/OC(C)C)\O)/C(=N2)C
  • InChi: 1S/C25H31NO8/c1-11(2)34-25(30)19-13(4)26-15-8-12(3)18(24(29)33-7)23(28)21(15)20(19)14-9-16(31-5)22(27)17(10-14)32-6/h9-12,18,20,27,30H,8H2,1-7H3
  • InChiKey: DBMUAAVQOJPEPB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii casein kinase ii regulatory subunit protein 0.0035 0.0061 0.054
Schistosoma mansoni survival motor neuron protein 0.0047 0.01 0.028
Trichomonas vaginalis conserved hypothetical protein 0.0191 0.059 0.2579
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0191 0.059 0.5605
Loa Loa (eye worm) hypothetical protein 0.0023 0.002 0.0066
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0059 0.0141 0.04
Trichomonas vaginalis PIKK family atypical protein kinase 0.0331 0.1063 0.4666
Plasmodium falciparum casein kinase 2, alpha subunit 0.0132 0.039 0.8609
Echinococcus granulosus phosphatidylinositol 3 kinase regulatory subunit 0.0084 0.0225 0.0221
Trichomonas vaginalis casein kinase II beta chain, putative 0.0035 0.0061 0.0252
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0333 0.1073 0.4707
Schistosoma mansoni serine/threonine protein kinase 0.0185 0.057 0.1663
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0331 0.1064 0.9463
Trichomonas vaginalis PIKK family atypical protein kinase 0.0209 0.0652 0.2851
Loa Loa (eye worm) hypothetical protein 0.0023 0.002 0.0066
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0028 0.0038 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0005
Plasmodium vivax hypothetical protein, conserved 0.0019 0.0005 0.0112
Brugia malayi Serotonin receptor 0.0451 0.1471 0.6459
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0028 0.0038 0.0147
Trichomonas vaginalis PIKK family atypical protein kinase 0.0326 0.1048 0.4599
Loa Loa (eye worm) hypothetical protein 0.0117 0.0338 0.1124
Trichomonas vaginalis CAMK family protein kinase 0.0185 0.057 0.2492
Trypanosoma brucei Casein kinase II 0.0132 0.039 0.3445
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0019 0.0005 0.0164
Echinococcus multilocularis phosphatidylinositol 3 kinase regulatory subunit 0.0084 0.0225 0.0221
Trichomonas vaginalis PIKK family atypical protein kinase 0.0308 0.0988 0.4333
Brugia malayi Protein kinase domain containing protein 0.031 0.0995 0.4363
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0508 0.1665 0.7317
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.002 0.0666
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0059 0.0141 0.0604
Trichomonas vaginalis CAMK family protein kinase 0.0185 0.057 0.2492
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0151 0.0453 1
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0074 0.0193 0.0832
Loa Loa (eye worm) hypothetical protein 0.0019 0.0004 0.0014
Loa Loa (eye worm) 6-phosphofructokinase 0.0105 0.0298 0.099
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0339 0.1093 0.3187
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0074 0.0193 0.0551
Onchocerca volvulus Casein kinase II subunit beta homolog 0.0035 0.0061 0.0427
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0348 0.1124 0.3053
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.031 0.0995 0.0991
Brugia malayi hypoxia-induced factor 1 0.0145 0.0435 0.1898
Echinococcus granulosus high voltage activated calcium channel beta 0.0084 0.0226 0.0222
Onchocerca volvulus Serine\/threonine kinase homolog 0.0185 0.057 0.5643
Schistosoma mansoni fkbp-rapamycin associated protein 0.0174 0.0531 0.1549
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0191 0.059 0.4492
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0059 0.0141 0.0604
Loa Loa (eye worm) hypothetical protein 0.0019 0.0004 0.0014
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0184 0.0566 0.2476
Trichomonas vaginalis PIKK family atypical protein kinase 0.0313 0.1003 0.4401
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0026 0.003 0.0112
Mycobacterium tuberculosis Conserved hypothetical protein 0.0074 0.0193 0.6482
Trypanosoma cruzi target of rapamycin kinase 3 0.0331 0.1064 0.3102
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0174 0.0531 0.0527
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0348 0.1124 0.3278
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0026 0.003 0.0112
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0031 0.0046 0.0042
Plasmodium falciparum glycogen synthase kinase 3 0.0049 0.0108 0.2392
Entamoeba histolytica hypothetical protein 0.0035 0.0059 0.0243
Trypanosoma cruzi hypothetical protein, conserved 0.1024 0.3418 1
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0059 0.0141 0.0604
Echinococcus multilocularis expressed conserved protein 0.0079 0.0209 0.0205
Trichomonas vaginalis phosphofructokinase, putative 0.0105 0.0298 0.1293
Trichomonas vaginalis PIKK family atypical protein kinase 0.0331 0.1063 0.4666
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0031 0.0046 0.0042
Schistosoma mansoni 6-phosphofructokinase 0.0105 0.0298 0.0863
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0022 0.0015 0.0051
Leishmania major hypothetical protein, unknown function 0.0074 0.0193 0.0513
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0059 0.0141 0.0604
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.01 0.042
Trichomonas vaginalis PIKK family atypical protein kinase 0.0301 0.0963 0.4224
Toxoplasma gondii hypothetical protein 0.0052 0.0117 0.1071
Brugia malayi follicle stimulating hormone receptor 0.0228 0.0716 0.3137
Echinococcus granulosus single minded 2 0.0035 0.0059 0.0055
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0049 0.0108 0.0991
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0031 0.0046 0.0042
Mycobacterium ulcerans putative regulatory protein 0.0019 0.0005 0.0171
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0022 0.0015 0.0049
Trichomonas vaginalis casein kinase II beta chain, putative 0.0035 0.0061 0.0252
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0174 0.0531 0.1542
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.002 0.0666
Trichomonas vaginalis CAMK family protein kinase 0.0185 0.057 0.2492
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0074 0.0193 0.4257
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0059 0.0141 0.0604
Trichomonas vaginalis PIKK family atypical protein kinase 0.0308 0.0988 0.4334
Trichomonas vaginalis PIKK family atypical protein kinase 0.0209 0.0652 0.2851
Brugia malayi 6-phosphofructokinase 0.0105 0.0298 0.1293
Trichomonas vaginalis PIKK family atypical protein kinase 0.0209 0.0652 0.2851
Brugia malayi Protein kinase domain containing protein 0.0129 0.038 0.1655
Schistosoma mansoni serine/threonine protein kinase 0.031 0.0995 0.2912
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0491 0.1609 0.1605
Echinococcus multilocularis Zinc finger, PHD finger 0.0151 0.0453 0.0449
Echinococcus multilocularis voltage dependent calcium channel 0.0031 0.0046 0.0042
Trichomonas vaginalis casein kinase II beta chain, putative 0.0035 0.0061 0.0252
Entamoeba histolytica hypothetical protein 0.0074 0.0193 0.0832
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0151 0.0453 0.4298
Schistosoma mansoni hypothetical protein 0.0074 0.0193 0.0555
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0687 0.2274 0.6649
Brugia malayi hypothetical protein 0.0035 0.0059 0.0243
Trichomonas vaginalis PIKK family atypical protein kinase 0.0326 0.1048 0.4599
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0268 0.0851 0.3729
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.002 0.0041
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0151 0.0453 0.1224
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.002 0.0504
Trichomonas vaginalis PIKK family atypical protein kinase 0.0308 0.0988 0.4334
Plasmodium vivax hypothetical protein, conserved 0.0074 0.0193 0.4257
Trichomonas vaginalis PIKK family atypical protein kinase 0.0326 0.1048 0.4599
Mycobacterium leprae conserved hypothetical protein 0.0074 0.0193 0.6421
Loa Loa (eye worm) PXA domain-containing protein 0.002 0.0009 0.0029
Giardia lamblia Kinase, CMGC CK2 0.0132 0.039 0.2867
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0348 0.1124 0.112
Giardia lamblia GTOR 0.0348 0.1124 0.8828
Trichomonas vaginalis CMGC family protein kinase 0.0132 0.039 0.1701
Trypanosoma cruzi Casein kinase II subunit beta, putative 0.0035 0.0061 0.0166
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0174 0.0531 0.2321
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0391 0.1268 1
Schistosoma mansoni casein kinase II beta subunit 0.0035 0.0061 0.0168
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0049 0.0108 0.0104
Trypanosoma brucei polo-like protein kinase 0.0185 0.057 0.505
Trichomonas vaginalis phosphofructokinase, putative 0.0028 0.0038 0.0147
Trichomonas vaginalis CAMK family protein kinase 0.0185 0.057 0.2492
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0031 0.0046 0.0042
Schistosoma mansoni serine/threonine protein kinase 0.0022 0.0015 0.0033
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0151 0.0453 0.0449
Leishmania major phosphatidylinositol kinase related protein, putative 0.0088 0.0241 0.0644
Toxoplasma gondii CMGC kinase, CK2 family 0.0132 0.039 0.3693
Loa Loa (eye worm) phosphatidylinositol 3 0.0348 0.1124 0.3735
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0026 0.003 0.0025
Trichomonas vaginalis PIKK family atypical protein kinase 0.0326 0.1048 0.4599
Schistosoma mansoni single-minded 0.0047 0.0101 0.0284
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.011 0.0313 0.2757
Onchocerca volvulus 0.0048 0.0104 0.0858
Entamoeba histolytica protein kinase domain containing protein 0.0132 0.039 0.1701
Echinococcus granulosus 6 phosphofructokinase 0.0105 0.0298 0.0294
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0074 0.0193 0.0189
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.0257 0.1114
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0031 0.0046 0.0124
Trypanosoma cruzi casein kinase II, putative 0.0132 0.039 0.1129
Schistosoma mansoni 6-phosphofructokinase 0.0105 0.0298 0.0863
Loa Loa (eye worm) CAMK/PIM protein kinase 0.031 0.0995 0.3306
Loa Loa (eye worm) cytochrome P450 family protein 0.0019 0.0005 0.0016
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0339 0.1093 0.1089
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0059 0.0141 0.04
Echinococcus multilocularis high voltage activated calcium channel beta 0.0084 0.0226 0.0222
Entamoeba histolytica protein kinase domain containing protein 0.0049 0.0108 0.0459
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0301 0.0963 0.8564
Mycobacterium ulcerans hypothetical protein 0.0023 0.002 0.0666
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0074 0.0193 0.4257
Toxoplasma gondii phosphofructokinase PFKII 0.0028 0.0038 0.0312
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0151 0.0453 0.1507
Entamoeba histolytica phosphofructokinase, putative 0.0105 0.0298 0.1293
Echinococcus multilocularis voltage dependent calcium channel 0.0031 0.0046 0.0042
Trichomonas vaginalis PIKK family atypical protein kinase 0.0348 0.1124 0.4932
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0348 0.1124 0.4932
Schistosoma mansoni high voltage-activated calcium channel beta subunit 2 0.0084 0.0226 0.0651
Echinococcus granulosus casein kinase ii subunit beta 0.0035 0.0061 0.0057
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0105 0.0298 1
Entamoeba histolytica casein kinase, putative 0.0132 0.039 0.1701
Loa Loa (eye worm) hypothetical protein 0.0191 0.059 0.196
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0268 0.0851 0.3729
Trichomonas vaginalis phosphofructokinase, putative 0.0028 0.0038 0.0147
Loa Loa (eye worm) hypothetical protein 0.024 0.0756 0.2513
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0074 0.0193 0.1681
Trypanosoma cruzi polo-like protein kinase, putative 0.0185 0.057 0.1655
Trichomonas vaginalis CMGC family protein kinase 0.0049 0.0108 0.0459
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0301 0.0963 0.2615
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0291 0.0928 0.8249
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0348 0.1124 0.4932
Trichomonas vaginalis CMGC family protein kinase 0.0132 0.039 0.1701
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.002 0.0069
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.0019 0.0005 0.0171
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0035 0.0061 0.0252
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0151 0.0453 0.1979
Entamoeba histolytica serine/threonine protein kinase, putative 0.0185 0.057 0.2492
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0093 0.0089
Trichomonas vaginalis PIKK family atypical protein kinase 0.0331 0.1063 0.4666
Entamoeba histolytica hypothetical protein 0.0188 0.0579 0.2533
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.1021 0.3406 0.3403
Trichomonas vaginalis PIKK family atypical protein kinase 0.0308 0.0988 0.4334
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0059 0.0141 0.0604
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.002 0.0666
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0059 0.0141 0.0604
Trichomonas vaginalis casein kinase II beta chain, putative 0.0035 0.0061 0.0252
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0074 0.0193 0.0551
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0093 0.0308
Trichomonas vaginalis CMGC family protein kinase 0.0132 0.039 0.1701
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0074 0.0193 0.0189
Trichomonas vaginalis PIKK family atypical protein kinase 0.0291 0.0928 0.4069
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0059 0.0141 0.0137
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0348 0.1124 0.112
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0093 0.026
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0074 0.0193 0.0832
Trichomonas vaginalis PIKK family atypical protein kinase 0.0326 0.1048 0.4599
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0049 0.0108 0.0283
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.002 0.0666
Schistosoma mansoni cellular tumor antigen P53 0.0048 0.0104 0.0292
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0035 0.0061 0.0252
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0188 0.0579 0.1683
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0059 0.0141 0.0604
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0028 0.0038 0.0312
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0059 0.0162
Loa Loa (eye worm) Csnk2b protein 0.0035 0.0061 0.0204
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0185 0.057 0.0566
Echinococcus granulosus expressed conserved protein 0.0079 0.0209 0.0205
Leishmania major hypothetical protein, conserved 0.1098 0.367 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0074 0.0193 0.0642
Loa Loa (eye worm) hypothetical protein 0.0048 0.0104 0.0344
Loa Loa (eye worm) CYP4Cod1 0.0019 0.0005 0.0016
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0026 0.003 0.0075
Loa Loa (eye worm) hypothetical protein 0.0328 0.1056 0.351
Trichomonas vaginalis CAMK family protein kinase 0.0185 0.057 0.2492
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0151 0.0453 0.1321
Brugia malayi Voltage-dependent L-type calcium channel beta-2 subunit 0.0173 0.0527 0.2305
Entamoeba histolytica hypothetical protein 0.0074 0.0193 0.0832
Echinococcus multilocularis transfer RNA-Lys 0.0035 0.0059 0.0055
Mycobacterium ulcerans 6-phosphofructokinase 0.0105 0.0298 1
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0074 0.0193 0.0189
Trichomonas vaginalis casein kinase II beta chain, putative 0.0035 0.0061 0.0252
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0074 0.0193 0.0551
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0074 0.0193 0.0189
Trichomonas vaginalis phosphofructokinase, putative 0.0105 0.0298 0.1293
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0059 0.0141 0.0604
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0093 0.026
Brugia malayi PXA domain containing protein 0.002 0.0009 0.002
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0059 0.0141 0.0604
Giardia lamblia Casein kinase II beta chain 0.0035 0.0061 0.0194
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0185 0.057 0.1542
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0074 0.0193 0.0832
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0268 0.0851 0.3729
Onchocerca volvulus 0.0035 0.0059 0.0406
Plasmodium vivax casein kinase 2, alpha subunit, putative 0.0132 0.039 0.8609
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0035 0.0061 0.0252
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0049 0.0108 0.0104
Leishmania major phosphatidylinositol 3-kinase, putative 0.0291 0.0928 0.2519
Echinococcus multilocularis 0.0074 0.0193 0.0189
Loa Loa (eye worm) hypothetical protein 0.0019 0.0004 0.0014
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.031 0.0995 1
Loa Loa (eye worm) hypoxia-induced factor 1 0.0145 0.0435 0.1446
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0151 0.0453 0.1314
Entamoeba histolytica hypothetical protein 0.0035 0.0059 0.0243
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0151 0.0453 0.4298
Toxoplasma gondii target of rapamycin (TOR), putative 0.0326 0.1048 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0074 0.0193 0.0642
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0194 0.0599 0.1741
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0185 0.057 0.1894
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0059 0.0141 0.0604
Trichomonas vaginalis PIKK family atypical protein kinase 0.0214 0.0667 0.2918
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0151 0.0453 0.1979
Trichomonas vaginalis phosphofructokinase, putative 0.0028 0.0038 0.0147
Loa Loa (eye worm) RGS-3 protein 0.0019 0.0004 0.0014
Plasmodium vivax hypothetical protein 0.0074 0.0193 0.4257
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0687 0.2274 1
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0059 0.0141 0.0403
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0059 0.0055
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0019 0.0004 0.0014
Trypanosoma cruzi Casein kinase II subunit beta, putative 0.0035 0.0061 0.0166
Trichomonas vaginalis PIKK family atypical protein kinase 0.0308 0.0988 0.4333
Trichomonas vaginalis conserved hypothetical protein 0.0117 0.0338 0.1471
Entamoeba histolytica hypothetical protein 0.057 0.1877 0.825
Brugia malayi Casein kinase II, alpha chain 0.0132 0.039 0.1701
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0059 0.0141 0.122
Schistosoma mansoni hypothetical protein 0.0047 0.01 0.028
Trichomonas vaginalis PIKK family atypical protein kinase 0.0308 0.0988 0.4333
Brugia malayi Cytochrome P450 family protein 0.0019 0.0005 0.0003
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.002 0.0041
Echinococcus multilocularis serine protein kinase ATM 0.0188 0.0579 0.0575
Loa Loa (eye worm) hypothetical protein 0.0158 0.0476 0.1584
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0687 0.2274 0.6649
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0074 0.0193 0.0555
Giardia lamblia Hypothetical protein 0.0074 0.0193 0.1263
Onchocerca volvulus 0.0049 0.0108 0.0909
Entamoeba histolytica protein kinase rad3, putative 0.0174 0.0531 0.2321
Trichomonas vaginalis phosphofructokinase, putative 0.0028 0.0038 0.0147
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0508 0.1665 0.7317
Loa Loa (eye worm) gastrulation defective protein 1 0.0126 0.0369 0.1226
Plasmodium falciparum GAF domain-related protein, putative 0.0019 0.0005 0.0112
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0059 0.0055
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0059 0.0141 0.0604
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0031 0.0046 0.0042
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0151 0.0453 0.0449
Trichomonas vaginalis casein kinase II beta chain, putative 0.0035 0.0061 0.0252
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0059 0.0141 0.0604
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.002 0.0666
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0613 0.2023 0.8891
Plasmodium vivax 6-phosphofructokinase, putative 0.0028 0.0038 0.083
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0348 0.1124 0.3053
Brugia malayi AMP-binding enzyme family protein 0.0023 0.002 0.0069
Entamoeba histolytica phosphofructokinase, putative 0.0105 0.0298 0.1293
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.2964 1 1
Echinococcus multilocularis casein kinase ii subunit alpha 0.0132 0.039 0.0386
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0074 0.0193 0.1802
Echinococcus multilocularis casein kinase ii subunit beta 0.0035 0.0061 0.0057
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0074 0.0193 0.1802
Plasmodium vivax glycogen synthase kinase 3, putative 0.0049 0.0108 0.2392
Echinococcus granulosus survival motor neuron protein 1 0.0228 0.0717 0.0713
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.002 0.0666
Onchocerca volvulus 0.0074 0.0193 0.1777
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0093 0.039
Trichomonas vaginalis conserved hypothetical protein 0.01 0.0279 0.1213
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0105 0.0298 0.2618
Trichomonas vaginalis PIKK family atypical protein kinase 0.0184 0.0566 0.2476
Echinococcus multilocularis survival motor neuron protein 1 0.0228 0.0717 0.0713
Mycobacterium tuberculosis Two component sensor histidine kinase DosT 0.0019 0.0005 0.0171
Mycobacterium tuberculosis Two component sensor histidine kinase DevS 0.0019 0.0005 0.0171
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0491 0.1609 0.1605
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0151 0.0453 1
Leishmania major phosphatidylinositol 3-kinase, putative 0.0151 0.0453 0.1224
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0059 0.0141 0.0604
Trichomonas vaginalis PIKK family atypical protein kinase 0.0092 0.0253 0.1096
Entamoeba histolytica hypothetical protein 0.0074 0.0193 0.0832
Trichomonas vaginalis casein kinase II beta chain, putative 0.0035 0.0061 0.0252
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.002 0.0069
Trichomonas vaginalis CMGC family protein kinase 0.0132 0.039 0.1701
Loa Loa (eye worm) 6-phosphofructokinase 0.0105 0.0298 0.099
Loa Loa (eye worm) hypothetical protein 0.0228 0.0717 0.2382
Loa Loa (eye worm) hypothetical protein 0.0491 0.1609 0.5347
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0093 0.026
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0026 0.003 0.0112
Giardia lamblia Kinase, PLK 0.0185 0.057 0.4326
Toxoplasma gondii ck2 beta subunit 0.0035 0.0061 0.054
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0059 0.0141 0.0137
Loa Loa (eye worm) cytochrome P450 family protein 0.0029 0.0039 0.0129
Trichomonas vaginalis PIKK family atypical protein kinase 0.0188 0.0579 0.2533
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0074 0.0193 0.0189
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0331 0.1064 0.2889
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.002 0.0504
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.1021 0.3406 0.3403
Trichomonas vaginalis casein kinase II beta chain, putative 0.0035 0.0061 0.0252
Echinococcus multilocularis beta adrenergic receptor kinase 0.0022 0.0015 0.0011
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0151 0.0453 0.0449
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0059 0.0141 0.0604
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0031 0.0046 0.0042
Onchocerca volvulus Casein kinase II subunit beta homolog 0.0035 0.0061 0.0427
Schistosoma mansoni protein kinase 0.0132 0.039 0.1135
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0105 0.0298 1
Brugia malayi serine/threonine-protein kinase plk-2 0.0185 0.057 0.2492
Brugia malayi PXA domain containing protein 0.002 0.0009 0.002
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0074 0.0193 0.0832
Trichomonas vaginalis CMGC family protein kinase 0.0132 0.039 0.1701
Entamoeba histolytica protein kinase domain containing protein 0.0049 0.0108 0.0459
Trichomonas vaginalis CAMK family protein kinase 0.0185 0.057 0.2492
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0031 0.0046 0.0186
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.004 0.0078 0.0324
Brugia malayi 6-phosphofructokinase 0.0105 0.0298 0.1293
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0093 0.0089
Loa Loa (eye worm) phosphatidylinositol 3 0.0904 0.3009 1
Brugia malayi Csnk2b protein 0.0035 0.0061 0.0252
Loa Loa (eye worm) phosphatidylinositol 3 0.0194 0.0599 0.1991
Loa Loa (eye worm) hypothetical protein 0.0019 0.0004 0.0014
Loa Loa (eye worm) calcium channel 0.0031 0.0046 0.0154
Loa Loa (eye worm) hypothetical protein 0.0174 0.0531 0.1765
Trichomonas vaginalis PIKK family atypical protein kinase 0.0326 0.1048 0.4599
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.004 0.0078 0.0324
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0117 0.0496
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0114 0.0327 0.0945
Trichomonas vaginalis casein kinase II beta chain, putative 0.0035 0.0061 0.0252
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0059 0.0141 0.0604
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0117 0.0338 0.0334
Trichomonas vaginalis PIKK family atypical protein kinase 0.0074 0.0193 0.0832
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0031 0.0046 0.0124
Onchocerca volvulus 0.0074 0.0193 0.1777
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0105 0.0298 0.0858
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0268 0.0851 0.756
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0348 0.1124 0.3278
Leishmania major protein kinase ck2 regulatory subunit, putative 0.0035 0.0061 0.0154
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0049 0.0108 0.0304
Entamoeba histolytica hypothetical protein 0.0035 0.0059 0.0243
Echinococcus multilocularis cyclin dependent kinase 19 0.0129 0.038 0.0376
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0348 0.1124 0.4932
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0074 0.0193 0.0832
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0151 0.0453 0.1314
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0339 0.1093 0.3187
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.031 0.0995 0.0991
Trichomonas vaginalis PIKK family atypical protein kinase 0.0331 0.1063 0.4666
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0074 0.0193 0.4257
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0059 0.0141 0.04
Brugia malayi FAT domain containing protein 0.0117 0.0338 0.1471
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0059 0.0141 0.0604
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0059 0.0141 0.0604
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.002 0.0666
Loa Loa (eye worm) hypothetical protein 0.0019 0.0004 0.0014
Brugia malayi hypothetical protein 0.0158 0.0476 0.208
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0151 0.0453 0.1979
Plasmodium falciparum casein kinase II beta chain 0.0035 0.0061 0.1356
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0059 0.0141 0.0604
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0049 0.0108 0.0361
Trichomonas vaginalis PIKK family atypical protein kinase 0.0308 0.0988 0.4334
Trichomonas vaginalis phosphofructokinase, putative 0.0028 0.0038 0.0147
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0026 0.003 0.0112
Loa Loa (eye worm) CMGC/CK2 protein kinase 0.0132 0.039 0.1298
Trichomonas vaginalis casein kinase II beta chain, putative 0.0035 0.0061 0.0252
Loa Loa (eye worm) cytochrome P450 family protein 0.0019 0.0005 0.0016
Giardia lamblia Kinase, CMGC GSK 0.0049 0.0108 0.0576
Loa Loa (eye worm) hypothetical protein 0.0019 0.0004 0.0014
Plasmodium vivax 6-phosphofructokinase, putative 0.0028 0.0038 0.083
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0059 0.0141 0.0604
Brugia malayi AMP-binding enzyme family protein 0.0023 0.002 0.0069
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0151 0.0453 0.1321
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0074 0.0193 0.1681
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0348 0.1124 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.002 0.0066
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0687 0.2274 1
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0117 0.0496
Leishmania major ATP-dependent phosphofructokinase 0.0105 0.0298 0.0799
Trichomonas vaginalis PIKK family atypical protein kinase 0.0231 0.0725 0.3177
Entamoeba histolytica hypothetical protein 0.0035 0.0059 0.0243
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0268 0.0851 0.3729
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.033 0.1063 0.4662
Schistosoma mansoni serine/threonine protein kinase 0.0022 0.0015 0.0033
Entamoeba histolytica phosphofructokinase, putative 0.0105 0.0298 0.1293
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0093 0.0089
Echinococcus granulosus tumor protein p63 0.0326 0.1049 0.1046
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0028 0.0038 0.083
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.002 0.0666
Giardia lamblia Phosphatidylinositol 4-kinase 0.0074 0.0193 0.1263
Brugia malayi intracellular kinase 0.0049 0.0108 0.0459
Trichomonas vaginalis CMGC family protein kinase 0.0132 0.039 0.1701
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0209 0.065 0.5766
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0174 0.0531 0.0527
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0031 0.0046 0.0042
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0105 0.0298 1
Echinococcus multilocularis 6 phosphofructokinase 0.0105 0.0298 0.0294
Schistosoma mansoni hypothetical protein 0.0079 0.0209 0.0601
Leishmania major phosphatidylinositol 4-kinase, putative 0.0074 0.0193 0.0513
Echinococcus multilocularis protein kinase shaggy 0.0049 0.0108 0.0104
Loa Loa (eye worm) phosphatidylinositol kinase 0.0074 0.0193 0.0642
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0151 0.0453 0.1979
Loa Loa (eye worm) CAMK/PIM protein kinase 0.031 0.0995 0.3306
Trichomonas vaginalis PIKK family atypical protein kinase 0.0331 0.1063 0.4666
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0312 0.1 0.4385
Echinococcus granulosus protein kinase shaggy 0.0049 0.0108 0.0104
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.1021 0.3406 1
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0074 0.0193 0.1802
Leishmania major casein kinase II, putative 0.0132 0.039 0.1052
Trichomonas vaginalis phosphofructokinase, putative 0.0105 0.0298 0.1293
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0687 0.2274 1
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0059 0.0141 0.0604
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0268 0.0851 0.2478
Brugia malayi Serine/threonine-protein kinase Pim-3 0.031 0.0995 0.4363
Trypanosoma brucei Casein kinase II subunit beta, putative 0.0035 0.0061 0.0506
Trichomonas vaginalis phosphofructokinase, putative 0.0105 0.0298 0.1293
Plasmodium falciparum casein kinase II beta chain 0.0035 0.0061 0.1356
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0151 0.0453 0.4009
Trichomonas vaginalis CMGC family protein kinase 0.0049 0.0108 0.0459
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0059 0.0141 0.0604
Loa Loa (eye worm) phosphatidylinositol 3 0.0301 0.0963 0.3201
Trichomonas vaginalis PIKK family atypical protein kinase 0.0348 0.1124 0.4932
Trypanosoma brucei protein kinase, putative 0.0049 0.0108 0.0926
Brugia malayi hypothetical protein 0.0228 0.0717 0.3138
Loa Loa (eye worm) hypothetical protein 0.0114 0.0327 0.1089
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0022 0.0015 0.0051
Mycobacterium ulcerans putative regulatory protein 0.0019 0.0005 0.0171
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0151 0.0453 0.1979
Trichomonas vaginalis PIKK family atypical protein kinase 0.0348 0.1124 0.4932
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0117 0.0338 0.0334
Toxoplasma gondii FATC domain-containing protein 0.0188 0.0579 0.5503
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.002 0.0666
Loa Loa (eye worm) voltage-dependent calcium channel beta 2a subunit 0.0173 0.0527 0.1753
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0074 0.0193 0.4257
Trichomonas vaginalis PIKK family atypical protein kinase 0.0231 0.0727 0.3184
Trichomonas vaginalis CAMK family protein kinase 0.0185 0.057 0.2492
Loa Loa (eye worm) hypothetical protein 0.0026 0.003 0.0099
Schistosoma mansoni hypothetical protein 0.0117 0.0338 0.0982
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0059 0.0141 0.122
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0185 0.057 0.0566
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0028 0.0038 0.083
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.057 0.1877 0.825
Brugia malayi AMP-binding enzyme family protein 0.0023 0.002 0.0069
Loa Loa (eye worm) hypothetical protein 0.0031 0.0046 0.0154
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0188 0.0579 0.2533
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0093 0.0089
Trypanosoma cruzi polo-like protein kinase, putative 0.0185 0.057 0.1655
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0494 0.1616 0.7101
Giardia lamblia Kinase, CMGC GSK 0.0049 0.0108 0.0576
Echinococcus granulosus casein kinase ii subunit alpha 0.0132 0.039 0.0386
Trichomonas vaginalis PIKK family atypical protein kinase 0.0291 0.0928 0.4069
Echinococcus multilocularis expressed protein 0.0361 0.1165 0.1162
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0348 0.1124 1
Echinococcus multilocularis tumor protein p63 0.0326 0.1049 0.1046
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0228 0.0716 0.2381
Loa Loa (eye worm) phosphofructokinase 0.0105 0.0298 0.099
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0026 0.003 0.0025
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0268 0.0851 0.3729
Trichomonas vaginalis PIKK family atypical protein kinase 0.0326 0.1048 0.4599
Schistosoma mansoni hypothetical protein 0.0035 0.0059 0.0162
Loa Loa (eye worm) phosphatidylinositol 3 0.0074 0.0193 0.0642
Echinococcus granulosus cyclin dependent kinase 19 0.0129 0.038 0.0376
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0074 0.0193 0.0555
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0117 0.0496
Trichomonas vaginalis PIKK family atypical protein kinase 0.0074 0.0193 0.0832
Loa Loa (eye worm) phosphatidylinositol 3 0.0074 0.0193 0.0642
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0314 0.1007 0.2949
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0049 0.0108 0.0307
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0071 0.0183 0.0179
Echinococcus granulosus voltage dependent calcium channel 0.0031 0.0046 0.0042
Trichomonas vaginalis casein kinase II beta chain, putative 0.0035 0.0061 0.0252
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0188 0.0579 0.169
Schistosoma mansoni kinase 0.0095 0.0265 0.0767
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0339 0.1093 0.1089
Brugia malayi Cytochrome P450 family protein 0.0029 0.0039 0.0152
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.004 0.0078 0.0213
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0059 0.0141 0.0604
Entamoeba histolytica protein kinase, putative 0.0049 0.0108 0.0459
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0188 0.0579 0.5132
Brugia malayi SH2 domain containing protein 0.0328 0.1056 0.4633
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0687 0.2274 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0291 0.0928 0.4069
Mycobacterium ulcerans putative regulatory protein 0.0035 0.0059 0.1995
Loa Loa (eye worm) hypothetical protein 0.0019 0.0005 0.0017
Trichomonas vaginalis phosphofructokinase, putative 0.0028 0.0038 0.0147
Trichomonas vaginalis CMGC family protein kinase 0.0132 0.039 0.1701
Leishmania major phosphatidylinositol kinase, putative 0.0074 0.0193 0.0513
Plasmodium vivax unspecified product 0.0132 0.039 0.8609
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0059 0.0141 0.0604
Loa Loa (eye worm) CMGC/CDK/CDK8 protein kinase 0.0129 0.038 0.1263
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0074 0.0193 0.0555
Brugia malayi PAS domain containing protein 0.0047 0.0101 0.0426
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0059 0.0141 0.0604
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0059 0.0141 0.0604
Echinococcus granulosus beta-adrenergic receptor kinase 0.0022 0.0015 0.0011
Loa Loa (eye worm) phosphatidylinositol 3-kinase catalytic subunit gamma 0.0046 0.0098 0.0325
Loa Loa (eye worm) hypothetical protein 0.0074 0.0193 0.0642
Trichomonas vaginalis PIKK family atypical protein kinase 0.0174 0.0531 0.2321
Trichomonas vaginalis casein kinase II beta chain, putative 0.0035 0.0061 0.0252
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0783 0.26 0.2597
Toxoplasma gondii 6-phosphofructokinase 0.0028 0.0038 0.0312
Onchocerca volvulus 0.0047 0.01 0.0817
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0074 0.0193 0.0832
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0028 0.0038 1
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0687 0.2274 1
Plasmodium vivax casein kinase II beta chain, putative 0.0035 0.0061 0.1356
Trichomonas vaginalis casein kinase II beta chain, putative 0.0035 0.0061 0.0252
Trichomonas vaginalis casein kinase II beta chain, putative 0.0035 0.0061 0.0252
Trichomonas vaginalis PIKK family atypical protein kinase 0.01 0.0279 0.1213
Plasmodium vivax casein kinase II beta chain, putative 0.0035 0.0061 0.1356
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0026 0.003 0.0112
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0049 0.0108 0.0361
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0074 0.0193 0.4257
Trichomonas vaginalis conserved hypothetical protein 0.0059 0.0141 0.0604
Schistosoma mansoni serine/threonine protein kinase 0.0129 0.038 0.1105
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0059 0.0141 0.0604
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0088 0.0241 0.0692
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.0257 0.1114
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0005 0.0004
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0151 0.0453 0.1979
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.002 0.0069
Echinococcus granulosus expressed protein 0.0361 0.1165 0.1162
Brugia malayi bHLH-PAS transcription factor 0.0035 0.0059 0.0243
Echinococcus granulosus serine protein kinase ATM 0.0188 0.0579 0.0575
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0339 0.1093 0.4795
Trichomonas vaginalis casein kinase II beta chain, putative 0.0035 0.0061 0.0252
Brugia malayi Cytochrome P450 family protein 0.0019 0.0005 0.0003
Echinococcus granulosus nuclear factor of activated T cells 5 0.0071 0.0183 0.0179
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0339 0.1093 0.32
Schistosoma mansoni serine/threonine protein kinase 0.0022 0.0015 0.0033
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0348 0.1124 0.3291
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0028 0.0038 0.0147
Schistosoma mansoni aryl hydrocarbon receptor 0.0047 0.0101 0.0284
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0074 0.0193 0.0551
Brugia malayi phosphofructokinase 0.0105 0.0298 0.1293
Schistosoma mansoni voltage-gated cation channel 0.0031 0.0046 0.0124
Trichomonas vaginalis PIKK family atypical protein kinase 0.0291 0.0928 0.4069
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0059 0.0141 0.0604
Trichomonas vaginalis PIKK family atypical protein kinase 0.0313 0.1003 0.4401
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.002 0.0041

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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