Detailed information for compound 809289

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 342.407 | Formula: C20H23FN2O2
  • H donors: 0 H acceptors: 1 LogP: 2.92 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(=Cc1ccco1)CN1CCC(=O)N(CC1)Cc1ccccc1F
  • InChi: 1S/C20H23FN2O2/c1-16(13-18-6-4-12-25-18)14-22-9-8-20(24)23(11-10-22)15-17-5-2-3-7-19(17)21/h2-7,12-13H,8-11,14-15H2,1H3/b16-13+
  • InChiKey: AAGZDGFNXAYDFJ-DTQAZKPQSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus DNA polymerase alpha catalytic subunit homolog 0.0071 0.038 0.1732
Loa Loa (eye worm) hypothetical protein 0.0384 0.2192 0.6117
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0384 0.2192 1
Onchocerca volvulus 0.0384 0.2192 1
Schistosoma mansoni neuropeptide f receptor 76f 0.0384 0.2192 1
Onchocerca volvulus 0.0384 0.2192 1
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0019 0.0081 0.0748
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0384 0.2192 0.6117
Trypanosoma cruzi thymidine kinase, putative 0.0235 0.1328 1
Echinococcus multilocularis serotonin receptor 0.0384 0.2192 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0384 0.2192 1
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0134 0.0374
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0014 0.005 0.0226
Entamoeba histolytica UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase, putative 0.0192 0.1079 0.8119
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0009 0.0024 0.011
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0384 0.2192 0.6117
Echinococcus granulosus neuropeptide receptor A26 0.0384 0.2192 1
Onchocerca volvulus 0.0192 0.1079 0.4921
Loa Loa (eye worm) hypothetical protein 0.0017 0.007 0.0195
Loa Loa (eye worm) hypothetical protein 0.0009 0.0024 0.0067
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0019 0.0081 0.0081
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0384 0.2192 1
Brugia malayi RE15519p 0.0384 0.2192 0.6117
Echinococcus granulosus intermediate filament protein 0.0028 0.0134 0.0611
Loa Loa (eye worm) UDP-Galactose:b-N-acetylglucosamine b1,4-galactosyltransferase 4 0.0042 0.0212 0.0593
Plasmodium falciparum thioredoxin reductase 0.0055 0.0288 0.2669
Mycobacterium tuberculosis Probable phospho-N-acetylmuramoyl-pentappeptidetransferase MurX 0.1735 1 1
Leishmania major DNA polymerase epsilon catalytic subunit, putative 0.0014 0.0053 0.0399
Entamoeba histolytica hypothetical protein 0.0019 0.0078 0.0588
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0019 0.0081 0.0081
Schistosoma mansoni neuropeptide receptor 0.0384 0.2192 1
Echinococcus granulosus UDP N acetylglucosamine dolichyl phosphate 0.0192 0.1079 0.4921
Schistosoma mansoni axis inhibition protein axin 0.0019 0.0078 0.0356
Loa Loa (eye worm) hypothetical protein 0.0384 0.2192 0.6117
Loa Loa (eye worm) neuropeptide F receptor 0.0384 0.2192 0.6117
Trichomonas vaginalis mercuric reductase, putative 0.0019 0.0081 0.0607
Schistosoma mansoni biogenic amine (5HT) receptor 0.0384 0.2192 1
Leishmania major cytochrome p450-like protein 0.0013 0.0045 0.034
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0018 0.0076 0.0076
Echinococcus granulosus fmrfamide receptor 0.0384 0.2192 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0076 0.0573
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0078 0.0588
Echinococcus granulosus G protein coupled receptor 139 0.0384 0.2192 1
Plasmodium vivax DNA polymerase zeta catalytic subunit, putative 0.0014 0.0053 0.0491
Schistosoma mansoni z-protein (S1r protein) 0.0019 0.0078 0.0356
Echinococcus granulosus rhodopsin orphan GPCR 0.0384 0.2192 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0384 0.2192 1
Onchocerca volvulus 0.0384 0.2192 1
Onchocerca volvulus 0.0028 0.0134 0.0611
Trypanosoma cruzi thymidine kinase, putative 0.0235 0.1328 1
Echinococcus multilocularis g protein coupled receptor 0.0384 0.2192 1
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0384 0.2192 1
Trichomonas vaginalis phosphofructokinase, putative 0.0034 0.0168 0.1263
Echinococcus multilocularis DNA polymerase delta catalytic subunit 0.0014 0.0053 0.0242
Loa Loa (eye worm) DNA polymerase epsilon catalytic subunit 0.0006 0.0007 0.0021
Brugia malayi PXA domain containing protein 0.0019 0.0078 0.0218
Echinococcus multilocularis somatostatin receptor 0.0384 0.2192 1
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0015 0.0058 0.0539
Loa Loa (eye worm) thioredoxin reductase 0.0055 0.0288 0.0804
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0384 0.2192 1
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0078 0.0356
Schistosoma mansoni blooms syndrome DNA helicase 0.0018 0.0073 0.0332
Schistosoma mansoni UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase 0.0192 0.1079 0.4921
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0384 0.2192 1
Echinococcus granulosus thioredoxin glutathione reductase 0.0055 0.0288 0.1313
Echinococcus granulosus tm gpcr rhodopsin 0.0384 0.2192 1
Brugia malayi regulator of G-protein signaling egl-10 0.0019 0.0078 0.0218
Loa Loa (eye worm) hypothetical protein 0.0013 0.0047 0.013
Onchocerca volvulus 0.0384 0.2192 1
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0384 0.2192 1
Schistosoma mansoni hypothetical protein 0.0384 0.2192 1
Onchocerca volvulus 0.0384 0.2192 1
Brugia malayi ORL1-like opioid receptor 0.0384 0.2192 0.6117
Giardia lamblia Thymidine kinase 0.0235 0.1328 1
Entamoeba histolytica DNA polymerase zeta catalytic subunit, putative 0.0006 0.0007 0.0056
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0078 0.0356
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0384 0.2192 1
Trypanosoma cruzi DNA polymerase I alpha catalytic subunit, putative 0.0022 0.0101 0.0758
Loa Loa (eye worm) hypothetical protein 0.0384 0.2192 0.6117
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0384 0.2192 0.6117
Loa Loa (eye worm) hypothetical protein 0.0384 0.2192 0.6117
Onchocerca volvulus Neuropeptide F receptor homolog 0.0384 0.2192 1
Loa Loa (eye worm) hypothetical protein 0.0384 0.2192 0.6117
Giardia lamblia NADH oxidase lateral transfer candidate 0.0019 0.0081 0.0607
Loa Loa (eye worm) hypothetical protein 0.0384 0.2192 0.6117
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0384 0.2192 1
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0019 0.0081 0.0225
Brugia malayi phosphofructokinase 0.0126 0.07 0.1953
Schistosoma mansoni biogenic amine receptor 0.0384 0.2192 1
Leishmania major UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase, putative 0.0192 0.1079 0.8119
Echinococcus granulosus neuropeptide s receptor 0.0384 0.2192 1
Brugia malayi hypothetical protein 0.0019 0.0078 0.0218
Echinococcus granulosus biogenic amine 5HT receptor 0.0384 0.2192 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0074 0.0206
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.002 0.0084 0.0781
Loa Loa (eye worm) cytochrome P450 family protein 0.0013 0.0045 0.0126
Loa Loa (eye worm) hypothetical protein 0.0384 0.2192 0.6117
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0081 0.0607
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0384 0.2192 1
Echinococcus granulosus expressed protein 0.0361 0.206 0.94
Echinococcus multilocularis 6 phosphofructokinase 0.0126 0.07 0.3192
Brugia malayi sulfakinin receptor protein 0.0384 0.2192 0.6117
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0058 0.0162
Schistosoma mansoni amine GPCR 0.0384 0.2192 1
Trichomonas vaginalis glutathione reductase, putative 0.0019 0.0081 0.0607
Trichomonas vaginalis phosphofructokinase, putative 0.0034 0.0168 0.1263
Toxoplasma gondii DNA polymerase family B protein 0.0006 0.0007 0.0069
Brugia malayi G protein-coupled receptor 0.0384 0.2192 0.6117
Trichomonas vaginalis phosphofructokinase, putative 0.0034 0.0168 0.1263
Loa Loa (eye worm) hypothetical protein 0.0384 0.2192 0.6117
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0078 0.0356
Loa Loa (eye worm) hypothetical protein 0.0384 0.2192 0.6117
Leishmania major thymidine kinase, putative 0.0235 0.1328 1
Loa Loa (eye worm) hypothetical protein 0.0384 0.2192 0.6117
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0019 0.0081 0.0607
Loa Loa (eye worm) DNA-directed DNA polymerase III 0.0014 0.0053 0.0148
Onchocerca volvulus 0.0384 0.2192 1
Echinococcus granulosus g protein coupled receptor 0.0384 0.2192 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0078 0.0218
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0078 0.0588
Onchocerca volvulus 0.0384 0.2192 1
Echinococcus multilocularis neuropeptide Y receptor 0.0384 0.2192 1
Toxoplasma gondii DNA polymerase (pol2) superfamily protein 0.0042 0.0212 0.1966
Loa Loa (eye worm) hypothetical protein 0.0384 0.2192 0.6117
Schistosoma mansoni axis inhibition protein axin 0.0019 0.0078 0.0356
Leishmania major DNA polymerase I alpha catalytic subunit, putative 0.0022 0.0101 0.0758
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0076 0.0573
Loa Loa (eye worm) hypothetical protein 0.0019 0.0078 0.0218
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0019 0.0081 0.0081
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0009 0.0024 0.0067
Echinococcus granulosus rhodopsin orphan GPCR 0.0384 0.2192 1
Schistosoma mansoni beta-14-galactosyltransferase 0.0042 0.0212 0.0969
Trichomonas vaginalis phosphofructokinase, putative 0.0034 0.0168 0.1263
Loa Loa (eye worm) glycosyl transferase 0.0017 0.007 0.0195
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0125 0.0694 0.0694
Trichomonas vaginalis DNA polymerase zeta catalytic subunit, putative 0.0014 0.0053 0.0399
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0034 0.0168 0.1263
Echinococcus granulosus bloom syndrome protein 0.0022 0.01 0.0456
Echinococcus multilocularis rhodopsin orphan GPCR 0.0384 0.2192 1
Giardia lamblia DNA polymerase epsilon, catalytic subunit 0.0014 0.0053 0.0399
Schistosoma mansoni neuropeptide F-like receptor 0.0384 0.2192 1
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0018 0.0076 0.0573
Loa Loa (eye worm) 6-phosphofructokinase 0.0126 0.07 0.1953
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0019 0.0078 0.0218
Trypanosoma cruzi DNA polymerase delta catalytic subunit, putative 0.0014 0.0053 0.0399
Entamoeba histolytica phosphofructokinase, putative 0.0126 0.07 0.5266
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0384 0.2192 0.6117
Entamoeba histolytica DNA polymerase alpha catalytic subunit, putative 0.0015 0.0055 0.0414
Leishmania major DNA polymerase zeta catalytic subunit, putative 0.0006 0.0007 0.0056
Echinococcus granulosus peptide allatostatin:somatostatin 0.0384 0.2192 1
Entamoeba histolytica phosphofructokinase, putative 0.0126 0.07 0.5266
Loa Loa (eye worm) hypothetical protein 0.0384 0.2192 0.6117
Loa Loa (eye worm) hypothetical protein 0.0028 0.0134 0.0374
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0019 0.0078 0.0218
Brugia malayi hypothetical protein 0.0384 0.2192 0.6117
Echinococcus multilocularis rhodopsin orphan GPCR 0.0384 0.2192 1
Brugia malayi hypothetical protein 0.0384 0.2192 0.6117
Schistosoma mansoni beta-14-galactosyltransferase 34-related 0.0017 0.007 0.0319
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0384 0.2192 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0384 0.2192 1
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0126 0.07 0.07
Echinococcus multilocularis O glycosyltransferase 0.0079 0.0425 0.194
Onchocerca volvulus DNA polymerase epsilon catalytic subunit A homolog 0.0014 0.0053 0.0242
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0384 0.2192 1
Echinococcus granulosus sex peptide receptor 0.0384 0.2192 1
Schistosoma mansoni DNA helicase recq1 0.0009 0.0024 0.011
Trypanosoma brucei DNA polymerase alpha catalytic subunit 0.0022 0.0101 0.0758
Trichomonas vaginalis DNA polymerase delta catalytic subunit, putative 0.0014 0.0053 0.0399
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0034 0.0168 0.1263
Trypanosoma brucei DNA polymerase zeta catalytic subunit, putative 0.0014 0.0053 0.0399
Trichomonas vaginalis phosphofructokinase, putative 0.0126 0.07 0.5266
Brugia malayi glutathione reductase 0.0055 0.0288 0.0804
Echinococcus granulosus g protein coupled receptor 0.0384 0.2192 1
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0012 0.004 0.0299
Loa Loa (eye worm) UDP-N-acetylglucosamine-peptide N-acetylglucosaminyltransferase 0.0078 0.0424 0.1183
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0019 0.0078 0.0356
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0034 0.0168 0.1555
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0013 0.0045 0.0045
Echinococcus granulosus DNA polymerase zeta catalytic subunit 0.0014 0.0053 0.0242
Echinococcus multilocularis neuropeptide FF receptor 2 0.0384 0.2192 1
Loa Loa (eye worm) TYRA-2 protein 0.0384 0.2192 0.6117
Brugia malayi follicle stimulating hormone receptor 0.0625 0.3582 1
Loa Loa (eye worm) hypothetical protein 0.0009 0.0024 0.0066
Onchocerca volvulus 0.0384 0.2192 1
Schistosoma mansoni hypothetical protein 0.0384 0.2192 1
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0134 0.0374
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0019 0.0078 0.0218
Echinococcus multilocularis Regulator of G protein signaling 20 0.0019 0.0078 0.0356
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0019 0.0081 0.0748
Loa Loa (eye worm) cytochrome P450 family protein 0.0013 0.0045 0.0126
Echinococcus multilocularis lamin 0.0028 0.0134 0.0611
Trichomonas vaginalis phosphofructokinase, putative 0.0034 0.0168 0.1263
Brugia malayi Thioredoxin reductase 0.0055 0.0288 0.0804
Loa Loa (eye worm) hypothetical protein 0.0014 0.005 0.0138
Echinococcus multilocularis G protein coupled receptor 139 0.0384 0.2192 1
Onchocerca volvulus 0.0028 0.0134 0.0611
Mycobacterium tuberculosis Probable reductase 0.0125 0.0694 0.0694
Loa Loa (eye worm) PXA domain-containing protein 0.0019 0.0078 0.0218
Brugia malayi beta-1,4-galactosyltransferase VII 0.0042 0.0212 0.0593
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0384 0.2192 1
Echinococcus multilocularis Metazoa galactosyltransferase 0.0159 0.0891 0.4064
Treponema pallidum hypothetical protein 0.0031 0.0149 0.0149
Loa Loa (eye worm) DNA polymerase epsilon catalytic subunit 0.0008 0.0016 0.0046
Loa Loa (eye worm) hypothetical protein 0.0384 0.2192 0.6117
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0076 0.0573
Brugia malayi Galactosyltransferase family protein 0.0159 0.0891 0.2486
Loa Loa (eye worm) hypothetical protein 0.0384 0.2192 0.6117
Schistosoma mansoni neuropeptide receptor 0.0384 0.2192 1
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0014 0.005 0.0226
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0009 0.0024 0.011
Loa Loa (eye worm) hypothetical protein 0.0384 0.2192 0.6117
Echinococcus granulosus Regulator of G protein signaling 20 0.0019 0.0078 0.0356
Toxoplasma gondii glycosyl transferase 0.0017 0.007 0.0648
Brugia malayi 6-phosphofructokinase 0.0126 0.07 0.1953
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.0078 0.0356
Entamoeba histolytica recQ family helicase, putative 0.0012 0.004 0.0299
Brugia malayi GnHR receptor homolog 0.0384 0.2192 0.6117
Schistosoma mansoni hypothetical protein 0.0384 0.2192 1
Echinococcus multilocularis DNA polymerase zeta catalytic subunit 0.0014 0.0053 0.0242
Trichomonas vaginalis phosphofructokinase, putative 0.0034 0.0168 0.1263
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0014 0.0052 0.0144
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0078 0.0356
Trypanosoma cruzi DNA polymerase zeta catalytic subunit, putative 0.0006 0.0007 0.0056
Trichomonas vaginalis thymidine kinase, putative 0.0235 0.1328 1
Trypanosoma cruzi trypanothione reductase, putative 0.0055 0.0288 0.2167
Entamoeba histolytica DNA polymerase delta catalytic subunit, putative 0.0014 0.0053 0.0399
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0076 0.0573
Schistosoma mansoni biogenic amine receptor 0.0384 0.2192 1
Schistosoma mansoni neuropeptide receptor 0.0384 0.2192 1
Echinococcus granulosus alpha 1A adrenergic receptor 0.0384 0.2192 1
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0076 0.0347
Loa Loa (eye worm) hypothetical protein 0.0384 0.2192 0.6117
Echinococcus granulosus rhodopsin orphan GPCR 0.0384 0.2192 1
Schistosoma mansoni biogenic amine (5HT) receptor 0.0384 0.2192 1
Brugia malayi PXA domain containing protein 0.0019 0.0078 0.0218
Mycobacterium tuberculosis Conserved hypothetical protein 0.0149 0.0831 0.0831
Echinococcus multilocularis neuropeptide Y receptor 0.0384 0.2192 1
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0009 0.0024 0.0223
Echinococcus granulosus neuropeptide receptor 0.0384 0.2192 1
Schistosoma mansoni beta-14-galactosyltransferase 34-related 0.0042 0.0212 0.0969
Echinococcus multilocularis neuropeptide receptor A26 0.0384 0.2192 1
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0384 0.2192 1
Echinococcus multilocularis neuropeptides capa receptor 0.0384 0.2192 1
Brugia malayi Dopamine receptor 0.0384 0.2192 0.6117
Loa Loa (eye worm) hypothetical protein 0.0384 0.2192 0.6117
Echinococcus multilocularis bloom syndrome protein 0.0022 0.01 0.0456
Trichomonas vaginalis thymidine kinase, putative 0.0235 0.1328 1
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0009 0.0024 0.0067
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0019 0.0081 0.0081
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0384 0.2192 1
Loa Loa (eye worm) hypothetical protein 0.0384 0.2192 0.6117
Leishmania major trypanothione reductase 0.0055 0.0288 0.2167
Loa Loa (eye worm) hypothetical protein 0.0384 0.2192 0.6117
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0034 0.0168 0.0168
Echinococcus multilocularis musashi 0.0028 0.0134 0.0611
Echinococcus granulosus g-protein coupled receptor 0.0384 0.2192 1
Schistosoma mansoni lamin 0.0028 0.0134 0.0611
Schistosoma mansoni ap endonuclease 0.0018 0.0076 0.0347
Schistosoma mansoni o-linked n-acetylglucosamine transferase ogt 0.0079 0.0425 0.194
Echinococcus granulosus biogenic amine 5HT receptor 0.0384 0.2192 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0384 0.2192 1
Brugia malayi Cytochrome P450 family protein 0.0013 0.0045 0.0126
Echinococcus granulosus axis inhibition protein axin 0.0019 0.0078 0.0356
Echinococcus granulosus neuropeptide Y receptor 0.0384 0.2192 1
Plasmodium vivax DNA polymerase delta catalytic subunit, putative 0.0014 0.0053 0.0491
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0076 0.0573
Trichomonas vaginalis phosphofructokinase, putative 0.0126 0.07 0.5266
Schistosoma mansoni UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase 0.0192 0.1079 0.4921
Loa Loa (eye worm) G-protein coupled receptor 0.0384 0.2192 0.6117
Echinococcus multilocularis g-protein coupled receptor 0.0384 0.2192 1
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0055 0.0288 0.0288
Echinococcus multilocularis neuropeptide receptor 0.0384 0.2192 1
Echinococcus multilocularis dro:myosuppressin receptor 0.0384 0.2192 1
Brugia malayi intermediate filament protein 0.0028 0.0134 0.0374
Plasmodium falciparum DNA polymerase epsilon catalytic subunit A, putative 0.0008 0.0016 0.0153
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0019 0.0081 0.0607
Loa Loa (eye worm) hypothetical protein 0.0384 0.2192 0.6117
Plasmodium vivax thioredoxin reductase, putative 0.0055 0.0288 0.2669
Echinococcus granulosus tachykinin peptides receptor 99D 0.0384 0.2192 1
Toxoplasma gondii DNA polymerase family B protein 0.0014 0.0053 0.0491
Treponema pallidum exodeoxyribonuclease (exoA) 0.0018 0.0076 0.0076
Schistosoma mansoni amine GPCR 0.0384 0.2192 1
Loa Loa (eye worm) hypothetical protein 0.0384 0.2192 0.6117
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.0078 0.0356
Schistosoma mansoni phenylalanine decarboxylase 0.0042 0.0212 0.0969
Mycobacterium ulcerans 6-phosphofructokinase 0.0126 0.07 0.07
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0384 0.2192 1
Entamoeba histolytica hypothetical protein 0.0019 0.0078 0.0588
Echinococcus granulosus neuropeptide FF receptor 2 0.0384 0.2192 1
Loa Loa (eye worm) hypothetical protein 0.0384 0.2192 0.6117
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0.0076 0.0076
Echinococcus granulosus 7tm_1 domain containing protein 0.0384 0.2192 1
Leishmania major ATP-dependent phosphofructokinase 0.0126 0.07 0.5266
Echinococcus granulosus Metazoa galactosyltransferase 0.0159 0.0891 0.4064
Brugia malayi hypothetical protein 0.0384 0.2192 0.6117
Treponema pallidum hypothetical protein 0.0031 0.0149 0.0149
Mycobacterium tuberculosis Probable dehydrogenase 0.0125 0.0694 0.0694
Brugia malayi Serotonin receptor 0.0384 0.2192 0.6117
Echinococcus granulosus lamin dm0 0.0028 0.0134 0.0611
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0126 0.07 0.07
Loa Loa (eye worm) hypothetical protein 0.0384 0.2192 0.6117
Schistosoma mansoni hypothetical protein 0.013 0.0722 0.3292
Brugia malayi A-kinase anchor protein 10, precursor 0.0019 0.0078 0.0218
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0139 0.0775 0.0775
Onchocerca volvulus 0.0384 0.2192 1
Schistosoma mansoni biogenic amine receptor 0.0384 0.2192 1
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0078 0.0356
Echinococcus granulosus DNA polymerase delta catalytic subunit 0.0014 0.0053 0.0242
Loa Loa (eye worm) hypothetical protein 0.0384 0.2192 0.6117
Trypanosoma cruzi UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase, putative 0.0192 0.1079 0.8119
Treponema pallidum phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) 0.1735 1 1
Plasmodium falciparum DNA polymerase delta catalytic subunit 0.0014 0.0053 0.0491
Echinococcus multilocularis UDP N acetylglucosamine dolichyl phosphate 0.0192 0.1079 0.4921
Echinococcus multilocularis orexin receptor type 2 0.0384 0.2192 1
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0018 0.0076 0.0573
Toxoplasma gondii phosphofructokinase PFKII 0.0034 0.0168 0.1555
Echinococcus multilocularis allatostatin A receptor 0.0384 0.2192 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0384 0.2192 1
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0384 0.2192 1
Echinococcus granulosus polypeptide N acetylgalactosaminyltransferase 0.0017 0.007 0.0319
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0384 0.2192 1
Loa Loa (eye worm) hypothetical protein 0.0384 0.2192 0.6117
Trichomonas vaginalis DNA polymerase alpha catalytic subunit, putative 0.0022 0.0101 0.0758
Brugia malayi UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase 0.0192 0.1079 0.3011
Schistosoma mansoni amine GPCR 0.0384 0.2192 1
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0076 0.0347
Schistosoma mansoni lamin 0.0028 0.0134 0.0611
Schistosoma mansoni opsin-like receptor 0.0384 0.2192 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0081 0.0607
Loa Loa (eye worm) hypothetical protein 0.0384 0.2192 0.6117
Toxoplasma gondii 6-phosphofructokinase 0.0034 0.0168 0.1555
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0125 0.0694 0.0694
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0019 0.0081 0.0368
Schistosoma mansoni DNA polymerase epsilon catalytic subunit 0.0014 0.0053 0.0242
Loa Loa (eye worm) hypothetical protein 0.0013 0.0047 0.013
Onchocerca volvulus 0.0384 0.2192 1
Mycobacterium ulcerans undecapaprenyl-phosphate alpha-N-acetylglucosaminyltransferase Rfe 0.0192 0.1079 0.1079
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0019 0.0081 0.0748
Echinococcus granulosus lamin 0.0028 0.0134 0.0611
Mycobacterium ulcerans phospho-N-acetylmuramoyl-pentapeptide-transferase 0.1735 1 1
Loa Loa (eye worm) hypothetical protein 0.0384 0.2192 0.6117
Loa Loa (eye worm) hypothetical protein 0.0019 0.0078 0.0218
Echinococcus multilocularis rhodopsin orphan GPCR 0.0384 0.2192 1
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0019 0.0078 0.0218
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0384 0.2192 1
Plasmodium vivax N-acetylglucosamine-1-phosphate transferase, putative 0.0192 0.1079 1
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0009 0.0024 0.0223
Brugia malayi DNA polymerase family B containing protein 0.0014 0.0053 0.0148
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0019 0.0081 0.0607
Trypanosoma cruzi cytochrome P450, putative 0.0013 0.0045 0.034
Echinococcus multilocularis DNA polymerase alpha catalytic subunit 0.0051 0.0268 0.1224
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0019 0.0081 0.0607
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0384 0.2192 1
Brugia malayi hypothetical protein 0.0384 0.2192 0.6117
Onchocerca volvulus 0.0384 0.2192 1
Treponema pallidum hypothetical protein 0.0031 0.0149 0.0149
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0019 0.0081 0.0368
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0384 0.2192 1
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0625 0.3582 1
Echinococcus multilocularis neuropeptide receptor 0.0384 0.2192 1
Brugia malayi Bloom's syndrome protein homolog 0.0022 0.01 0.0279
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0081 0.0607
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0034 0.0168 0.1263
Toxoplasma gondii DNA polymerase 0.0014 0.0053 0.0491
Wolbachia endosymbiont of Brugia malayi hypothetical protein 0.0031 0.0149 0.0149
Schistosoma mansoni growth hormone secretagogue receptor 0.0384 0.2192 1
Onchocerca volvulus 0.0384 0.2192 1
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0034 0.0168 0.1555
Loa Loa (eye worm) neuropeptide F receptor 0.0384 0.2192 0.6117
Loa Loa (eye worm) CYP4Cod1 0.0013 0.0045 0.0126
Echinococcus multilocularis regulator of G protein signaling 0.0019 0.0078 0.0356
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0125 0.0694 0.0694
Mycobacterium tuberculosis Probable oxidoreductase 0.0139 0.0775 0.0775
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0014 0.0052 0.0144
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0384 0.2192 0.6117
Echinococcus multilocularis rhodopsin orphan GPCR 0.0384 0.2192 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0078 0.0218
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0384 0.2192 0.6117
Onchocerca volvulus DNA polymerase delta catalytic subunit homolog 0.0014 0.0053 0.0242
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0019 0.0078 0.0356
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0009 0.0024 0.0223
Onchocerca volvulus 0.0384 0.2192 1
Wolbachia endosymbiont of Brugia malayi hypothetical protein 0.0031 0.0149 0.0149
Loa Loa (eye worm) hypothetical protein 0.0019 0.0078 0.0218
Trypanosoma brucei UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase, putative 0.0192 0.1079 0.8119
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0058 0.0162
Brugia malayi hypothetical protein 0.0384 0.2192 0.6117
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0384 0.2192 0.6117
Schistosoma mansoni hypothetical protein 0.0025 0.0113 0.0517
Loa Loa (eye worm) G-protein coupled receptor 0.0384 0.2192 0.6117
Wolbachia endosymbiont of Brugia malayi phospho-N-acetylmuramoyl-pentapeptide-transferase 0.1735 1 1
Trypanosoma brucei RNA helicase, putative 0.013 0.0722 0.5432
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0019 0.0078 0.0356
Brugia malayi Dopamine receptor protein 2 0.0384 0.2192 0.6117
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0007 0.0056
Echinococcus multilocularis neuropeptides capa receptor 0.0384 0.2192 1
Trypanosoma cruzi cytochrome P450, putative 0.0013 0.0045 0.034
Schistosoma mansoni beta-14-galactosyltransferase 0.0042 0.0212 0.0969
Echinococcus multilocularis Metazoa galactosyltransferase 0.0134 0.0748 0.3414
Giardia lamblia Sgs1 DNA helicase, putative 0.0009 0.0024 0.0181
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0078 0.0588
Trypanosoma brucei DNA polymerase delta catalytic subunit, putative 0.0014 0.0053 0.0399
Schistosoma mansoni DNA polymerase alpha catalytic subunit 0.0019 0.0082 0.0375
Echinococcus granulosus neuropeptides capa receptor 0.0384 0.2192 1
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0134 0.0374
Toxoplasma gondii thioredoxin reductase 0.0055 0.0288 0.2669
Schistosoma mansoni DNA helicase recq5 0.0009 0.0024 0.011
Trypanosoma cruzi DNA polymerase delta catalytic subunit, putative 0.0006 0.0007 0.0056
Loa Loa (eye worm) hypothetical protein 0.0384 0.2192 0.6117
Schistosoma mansoni beta-14-galactosyltransferase 0.0025 0.0113 0.0517
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0.0078 0.0218
Echinococcus granulosus 6 phosphofructokinase 0.0126 0.07 0.3192
Brugia malayi AKH receptor 0.0384 0.2192 0.6117
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0125 0.0694 0.0694
Trypanosoma brucei thymidine kinase 0.0235 0.1328 1
Loa Loa (eye worm) hypothetical protein 0.0384 0.2192 0.6117
Echinococcus granulosus rhodopsin orphan GPCR 0.0384 0.2192 1
Loa Loa (eye worm) hypothetical protein 0.0384 0.2192 0.6117
Brugia malayi hypothetical protein 0.0019 0.0078 0.0218
Echinococcus multilocularis g protein coupled receptor 0.0384 0.2192 1
Toxoplasma gondii N-acetylgalactosaminyl transferase 0.0017 0.007 0.0648
Schistosoma mansoni ap endonuclease 0.0018 0.0076 0.0347
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0019 0.0081 0.0607
Echinococcus multilocularis fmrfamide receptor 0.0384 0.2192 1
Treponema pallidum NADH oxidase 0.0019 0.0081 0.0081
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0078 0.0588
Brugia malayi Galactosyltransferase family protein 0.0042 0.0212 0.0593
Toxoplasma gondii NADPH-glutathione reductase 0.0019 0.0081 0.0748
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0009 0.0024 0.0067
Plasmodium falciparum glutathione reductase 0.0055 0.0288 0.2669
Echinococcus granulosus 7TM GPCR rhodopsin 0.0384 0.2192 1
Schistosoma mansoni DNA polymerase delta catalytic subunit 0.0014 0.0053 0.0242
Toxoplasma gondii hypothetical protein 0.0042 0.0212 0.197
Loa Loa (eye worm) hypothetical protein 0.0384 0.2192 0.6117
Loa Loa (eye worm) hypothetical protein 0.0006 0.0007 0.0021
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0012 0.004 0.0299
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.0078 0.0356
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0384 0.2192 1
Giardia lamblia O-linked GlcNAc transferase 0.0046 0.0234 0.1761
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0076 0.0573
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0019 0.0081 0.0748
Giardia lamblia O-linked GlcNAc transferase 0.0078 0.042 0.3163
Plasmodium vivax glutathione reductase, putative 0.0055 0.0288 0.2669
Brugia malayi putative neuropeptide receptor 0.0384 0.2192 0.6117
Trypanosoma brucei cytochrome P450, putative 0.0013 0.0045 0.034
Echinococcus multilocularis G-protein coupled receptor, putative 0.0384 0.2192 1
Brugia malayi Tachykinin-like peptides receptor 99D 0.0384 0.2192 0.6117
Schistosoma mansoni amine GPCR 0.0384 0.2192 1
Trichomonas vaginalis DNA helicase recq, putative 0.0022 0.01 0.0752
Schistosoma mansoni beta-14-galactosyltransferase 0.0042 0.0212 0.0969
Loa Loa (eye worm) hypothetical protein 0.0008 0.0016 0.0046
Echinococcus granulosus allatostatin A receptor 0.0384 0.2192 1
Plasmodium falciparum glutathione reductase 0.0019 0.0081 0.0748
Echinococcus granulosus g protein coupled receptor 0.0384 0.2192 1
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0019 0.0078 0.0356
Echinococcus multilocularis rhodopsin orphan GPCR 0.0384 0.2192 1
Plasmodium falciparum thioredoxin reductase 0.0019 0.0081 0.0748
Schistosoma mansoni beta-14-galactosyltransferase 0.0159 0.0891 0.4064
Brugia malayi UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 0.0078 0.0424 0.1183
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0019 0.0081 0.0368
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0384 0.2192 1
Schistosoma mansoni DNA polymerase zeta catalytic subunit 0.0014 0.0053 0.0242
Echinococcus granulosus Ribosomal protein L34a 0.0117 0.0649 0.2962
Echinococcus multilocularis dna polymerase epsilon catalytic subunit a 0.0014 0.0053 0.0242
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.0078 0.0356
Plasmodium falciparum UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase, putative 0.0192 0.1079 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0081 0.0607
Brugia malayi putative neuropeptide receptor NPR1 0.0384 0.2192 0.6117
Schistosoma mansoni beta-14-galactosyltransferase 0.0159 0.0891 0.4064
Leishmania major DNA polymerase delta catalytic subunit, putative 0.0014 0.0053 0.0399
Mycobacterium ulcerans hypothetical protein 0.0031 0.0149 0.0149
Onchocerca volvulus DNA polymerase homolog 0.0014 0.0053 0.0242
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0384 0.2192 1
Brugia malayi Cytochrome P450 family protein 0.0013 0.0045 0.0126
Brugia malayi hypothetical protein 0.0384 0.2192 0.6117
Giardia lamblia DNA polymerase alpha subunit A 0.0044 0.0223 0.1676
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0076 0.0706
Onchocerca volvulus 0.0384 0.2192 1
Trypanosoma cruzi trypanothione reductase, putative 0.0019 0.0081 0.0607
Trypanosoma cruzi DNA polymerase epsilon catalytic subunit, putative 0.0014 0.0053 0.0399
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0384 0.2192 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0384 0.2192 1
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0126 0.07 0.5266
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0018 0.0076 0.0076
Loa Loa (eye worm) hypothetical protein 0.0384 0.2192 0.6117
Loa Loa (eye worm) hypothetical protein 0.0384 0.2192 0.6117
Entamoeba histolytica phosphofructokinase, putative 0.0126 0.07 0.5266
Brugia malayi Melatonin receptor type 1A 0.0384 0.2192 0.6117
Echinococcus granulosus hypothetical protein 0.0384 0.2192 1
Schistosoma mansoni beta-14-galactosyltransferase 0.0042 0.0212 0.0969
Trichomonas vaginalis DNA polymerase II, putative 0.0022 0.0101 0.0758
Schistosoma mansoni intermediate filament proteins 0.0028 0.0134 0.0611
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0384 0.2192 1
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0015 0.0057 0.0529
Echinococcus granulosus tm gpcr rhodopsin 0.0384 0.2192 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0384 0.2192 1
Loa Loa (eye worm) hypothetical protein 0.0384 0.2192 0.6117
Echinococcus granulosus rhodopsin orphan GPCR 0.0384 0.2192 1
Schistosoma mansoni amine GPCR 0.0384 0.2192 1
Trichomonas vaginalis DNA polymerase alpha catalytic subunit, putative 0.0008 0.0016 0.0124
Loa Loa (eye worm) hypothetical protein 0.0384 0.2192 0.6117
Schistosoma mansoni beta-14-galactosyltransferase 0.0042 0.0212 0.0969
Echinococcus granulosus serotonin receptor 0.0384 0.2192 1
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0384 0.2192 1
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0078 0.0356
Echinococcus granulosus tm gpcr rhodopsin 0.0384 0.2192 1
Echinococcus granulosus dna polymerase epsilon catalytic subunit a 0.0014 0.0053 0.0242
Onchocerca volvulus 0.0384 0.2192 1
Trypanosoma brucei trypanothione reductase 0.0055 0.0288 0.2167
Brugia malayi neuropeptide F receptor 0.0384 0.2192 0.6117
Onchocerca volvulus 0.0384 0.2192 1
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0034 0.0168 0.0168
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.0078 0.0356
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.0078 0.0356
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0384 0.2192 1
Schistosoma mansoni 6-phosphofructokinase 0.0126 0.07 0.3192
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0009 0.0024 0.011
Loa Loa (eye worm) hypothetical protein 0.0384 0.2192 0.6117
Entamoeba histolytica hypothetical protein 0.0019 0.0078 0.0588
Onchocerca volvulus 0.0384 0.2192 1
Schistosoma mansoni hypothetical protein 0.0384 0.2192 1
Trichomonas vaginalis glucosaminephosphotransferase, putative 0.0192 0.1079 0.8119
Giardia lamblia UDP-N-acetylglucosamine-dolichyl-phosphateN-acetylglucosaminephosphotransferase 0.0192 0.1079 0.8119
Plasmodium falciparum DNA polymerase zeta catalytic subunit, putative 0.0006 0.0007 0.0069
Schistosoma mansoni 6-phosphofructokinase 0.0126 0.07 0.3192
Plasmodium vivax DNA polymerase alpha, putative 0.0042 0.0212 0.1966
Echinococcus multilocularis beta 1,4 galactosyltransferase 7 0.0042 0.0212 0.0969
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0139 0.0775 0.0775
Brugia malayi hypothetical protein 0.0384 0.2192 0.6117
Trypanosoma cruzi UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase, putative 0.0192 0.1079 0.8119
Echinococcus multilocularis beta adrenergic receptor kinase 0.0019 0.0078 0.0356
Echinococcus multilocularis serotonin receptor 0.0384 0.2192 1
Schistosoma mansoni adenoreceptor 0.0384 0.2192 1
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0384 0.2192 1
Brugia malayi hypothetical protein 0.0384 0.2192 0.6117
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0019 0.0078 0.0588
Brugia malayi DNA polymerase delta catalytic subunit 0.0014 0.0053 0.0148
Loa Loa (eye worm) hypothetical protein 0.0384 0.2192 0.6117
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0384 0.2192 1
Schistosoma mansoni n-acetylgalactosaminyltransferase 0.0017 0.007 0.0319
Mycobacterium leprae Probable phospho-N-acetylmuramoyl-pentappeptidetransferase MurX 0.1735 1 1
Schistosoma mansoni beta-14-galactosyltransferase 0.0042 0.0212 0.0969
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0076 0.0212
Schistosoma mansoni myosin xvIII 0.0384 0.2192 1
Echinococcus granulosus beta 14 galactosyltransferase 7 0.0042 0.0212 0.0969
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0139 0.0775 0.0775
Loa Loa (eye worm) hypothetical protein 0.0384 0.2192 0.6117
Toxoplasma gondii glycosyl transferase, group 4 family protein 0.0192 0.1079 1
Trichomonas vaginalis phosphofructokinase, putative 0.0126 0.07 0.5266
Echinococcus granulosus beta 14 N acetylgalactosaminyltransferase 0.0042 0.0212 0.0969
Brugia malayi regulator of G-protein signaling rgs-7 0.0019 0.0078 0.0218
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.0078 0.0356
Schistosoma mansoni neuropeptide F-like receptor 0.0384 0.2192 1
Trichomonas vaginalis DNA helicase recq, putative 0.0012 0.004 0.0299
Trichomonas vaginalis thymidine kinase, putative 0.0235 0.1328 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0384 0.2192 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0384 0.2192 1
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0019 0.0081 0.0607
Loa Loa (eye worm) hypothetical protein 0.0384 0.2192 0.6117
Echinococcus multilocularis neuropeptide s receptor 0.0384 0.2192 1
Brugia malayi hypothetical protein 0.0384 0.2192 0.6117
Treponema pallidum hypothetical protein 0.0031 0.0149 0.0149
Brugia malayi Dopamine receptor protein 1 0.0384 0.2192 0.6117
Loa Loa (eye worm) hypothetical protein 0.0019 0.0078 0.0218
Schistosoma mansoni neuropeptide receptor 0.0384 0.2192 1
Brugia malayi Serotonin receptor 0.0384 0.2192 0.6117
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0384 0.2192 1
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.0078 0.0356
Echinococcus multilocularis g protein coupled receptor 0.0384 0.2192 1
Loa Loa (eye worm) hypothetical protein 0.0384 0.2192 0.6117
Brugia malayi larval opioid receptor 0.0384 0.2192 0.6117
Loa Loa (eye worm) hypothetical protein 0.0384 0.2192 0.6117
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0078 0.0356
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.0078 0.0356
Toxoplasma gondii O-linked N-acetylglucosamine transferase 0.0078 0.042 0.3896
Loa Loa (eye worm) galactosyltransferase 0.0042 0.0212 0.0593
Loa Loa (eye worm) melatonin receptor type 1A 0.0384 0.2192 0.6117
Echinococcus multilocularis beta 1,4 N acetylgalactosaminyltransferase 0.0042 0.0212 0.0969
Schistosoma mansoni histamine h1 receptor 0.0384 0.2192 1
Brugia malayi neuropeptide F receptor 0.0384 0.2192 0.6117
Echinococcus multilocularis lamin dm0 0.0028 0.0134 0.0611
Loa Loa (eye worm) hypothetical protein 0.0384 0.2192 0.6117
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0019 0.0081 0.0607
Echinococcus granulosus O glycosyltransferase 0.0079 0.0425 0.194
Echinococcus granulosus neuropeptide receptor 0.0384 0.2192 1
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0126 0.07 0.5266
Loa Loa (eye worm) hypothetical protein 0.0384 0.2192 0.6117
Brugia malayi G-protein coupled receptor 0.0384 0.2192 0.6117
Echinococcus granulosus neuropeptides capa receptor 0.0384 0.2192 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0384 0.2192 1
Trichomonas vaginalis DNA polymerase alpha catalytic subunit, putative 0.0014 0.0053 0.0399
Echinococcus granulosus orexin receptor type 2 0.0384 0.2192 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.0131 0.0365
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0012 0.004 0.0299
Echinococcus granulosus axis inhibition protein axin 0.0019 0.0078 0.0356
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0076 0.0212
Echinococcus multilocularis expressed protein 0.0361 0.206 0.94
Entamoeba histolytica thymidine kinase, putative 0.0235 0.1328 1
Echinococcus multilocularis fmrfamide receptor 0.0384 0.2192 1
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0126 0.07 0.07
Brugia malayi DNA polymerase alpha catalytic subunit 0.0042 0.0212 0.0592
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0019 0.0081 0.0748
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0.0078 0.0218
Brugia malayi G-protein coupled receptor 0.0384 0.2192 0.6117
Loa Loa (eye worm) glutathione reductase 0.0055 0.0288 0.0804
Echinococcus granulosus DNA polymerase alpha catalytic subunit 0.0051 0.0268 0.1224
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0019 0.0081 0.0607
Echinococcus granulosus somatostatin receptor 0.0384 0.2192 1
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0078 0.0588
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0384 0.2192 0.6117
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0019 0.0081 0.0607
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0081 0.0607
Schistosoma mansoni alpha-1 adrenergic receptor 0.0384 0.2192 1
Echinococcus granulosus beta-adrenergic receptor kinase 0.0019 0.0078 0.0356
Giardia lamblia DNA polymerase delta, catalytic subunit 0.0014 0.0053 0.0399
Schistosoma mansoni opsin-like receptor 0.0384 0.2192 1
Loa Loa (eye worm) hypothetical protein 0.0071 0.038 0.106
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0019 0.0081 0.0081
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0034 0.0168 0.0168
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0019 0.0078 0.0356
Brugia malayi G protein-coupled receptor F59B2.13 0.0384 0.2192 0.6117
Brugia malayi 6-phosphofructokinase 0.0126 0.07 0.1953
Trichomonas vaginalis phosphofructokinase, putative 0.0126 0.07 0.5266
Toxoplasma gondii exonuclease III APE 0.0018 0.0076 0.0706
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0078 0.0356
Loa Loa (eye worm) hypothetical protein 0.0384 0.2192 0.6117
Loa Loa (eye worm) hypothetical protein 0.0006 0.0007 0.0021
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0384 0.2192 1
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0019 0.0081 0.0081
Echinococcus multilocularis rhodopsin orphan GPCR 0.0384 0.2192 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0384 0.2192 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0384 0.2192 1
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0384 0.2192 1
Plasmodium falciparum DNA polymerase alpha catalytic subunit A 0.0015 0.0055 0.051
Echinococcus multilocularis sex peptide receptor 0.0384 0.2192 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0384 0.2192 1
Plasmodium vivax DNA polymerase epsilon, catalytic subunit a, putative 0.0014 0.0053 0.0491
Chlamydia trachomatis hypothetical protein 0.0031 0.0149 0.0149
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.0078 0.0356
Loa Loa (eye worm) beta-1,4-galactosyltransferase VII 0.0042 0.0212 0.0593
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0125 0.0694 0.0694
Schistosoma mansoni opsin-like receptor 0.0384 0.2192 1
Echinococcus granulosus neuropeptide Y receptor 0.0384 0.2192 1
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0019 0.0081 0.0607
Loa Loa (eye worm) hypothetical protein 0.0008 0.0016 0.0046
Echinococcus multilocularis rhodopsin orphan GPCR 0.0384 0.2192 1
Loa Loa (eye worm) RecQ helicase 0.0022 0.01 0.0279
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0009 0.0024 0.011
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0034 0.0168 0.1555
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0078 0.0588
Loa Loa (eye worm) phosphofructokinase 0.0126 0.07 0.1953
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0019 0.0081 0.0081
Plasmodium vivax 6-phosphofructokinase, putative 0.0034 0.0168 0.1555
Schistosoma mansoni DNA polymerase alpha catalytic subunit 0.0051 0.0268 0.1224
Echinococcus multilocularis Ribosomal protein L34a 0.0117 0.0649 0.2962
Echinococcus granulosus dro:myosuppressin receptor 0.0384 0.2192 1
Loa Loa (eye worm) RGS-3 protein 0.0019 0.0078 0.0218
Loa Loa (eye worm) hypothetical protein 0.0384 0.2192 0.6117
Loa Loa (eye worm) hypothetical protein 0.0192 0.1079 0.3011
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0384 0.2192 0.6117
Trypanosoma cruzi DNA polymerase epsilon catalytic subunit, putative 0.0014 0.0053 0.0399
Brugia malayi DNA polymerase family B, exonuclease domain containing protein 0.0014 0.0053 0.0148
Echinococcus multilocularis thioredoxin glutathione reductase 0.0055 0.0288 0.1313
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0384 0.2192 1
Loa Loa (eye worm) galactosyltransferase 0.0159 0.0891 0.2486
Plasmodium vivax 6-phosphofructokinase, putative 0.0034 0.0168 0.1555
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0076 0.0706
Trichomonas vaginalis DNA helicase recq1, putative 0.0022 0.01 0.0752
Loa Loa (eye worm) 6-phosphofructokinase 0.0126 0.07 0.1953
Brugia malayi hypothetical protein 0.0384 0.2192 0.6117
Trypanosoma brucei DNA polymerase epsilon catalytic subunit, putative 0.0014 0.0053 0.0399
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0081 0.0607

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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