Detailed information for compound 81484

Basic information

Technical information
  • TDR Targets ID: 81484
  • Name: 4-imidazol-1-yl-1-methyl-3,6-dihydro-2H-pyrid ine
  • MW: 163.22 | Formula: C9H13N3
  • H donors: 0 H acceptors: 1 LogP: 0.42 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: CN1CCC(=CC1)n1cncc1
  • InChi: 1S/C9H13N3/c1-11-5-2-9(3-6-11)12-7-4-10-8-12/h2,4,7-8H,3,5-6H2,1H3
  • InChiKey: APNYXLIAUGUVRR-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-(1-imidazolyl)-1-methyl-3,6-dihydro-2H-pyridine

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi metabotropic GABA-B receptor subtype 2 0.0122 0.0421 0.1145
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0046 0.0114 0.0892
Brugia malayi Receptor family ligand binding region containing protein 0.0267 0.1005 0.2731
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0088 0.0284 1
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0026 0.0032 0.0032
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0089 0.0287 0.0665
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0187 0.1481
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0088 0.0284 0.2261
Onchocerca volvulus 0.0026 0.0032 0.0082
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0109 0.0366 0.2921
Schistosoma mansoni ap endonuclease 0.0019 0.0003 0.0006
Wolbachia endosymbiont of Brugia malayi Na+/H+-dicarboxylate symporter 0.025 0.0936 1
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0046 0.0114 0.0892
Brugia malayi Pre-SET motif family protein 0.0622 0.2435 0.6618
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0166 0.1316
Brugia malayi hypothetical protein 0.012 0.0413 0.1122
Brugia malayi Zona pellucida-like domain containing protein 0.0046 0.0115 0.0312
Schistosoma mansoni glutamate receptor kainate 0.0111 0.0377 0.0873
Entamoeba histolytica hypothetical protein 0.0038 0.0082 0.064
Brugia malayi regulator of G-protein signaling rgs-7 0.0038 0.0082 0.0224
Treponema pallidum glutamate transporter 0.0111 0.0375 0.0565
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0009 0.0009
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0038 0.0126
Loa Loa (eye worm) hypothetical protein 0.0046 0.0115 0.0255
Brugia malayi von Willebrand factor type A domain containing protein 0.0046 0.0115 0.0312
Echinococcus granulosus histone lysine methyltransferase setb 0.0089 0.0287 0.0287
Loa Loa (eye worm) RecQ helicase 0.0043 0.0103 0.0228
Schistosoma mansoni axis inhibition protein axin 0.0038 0.0082 0.0191
Chlamydia trachomatis neutral amino acid transporter 0.0111 0.0375 0.1839
Treponema pallidum glutamate/aspartate transporter 0.0111 0.0375 0.0565
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0029 0.0045 0.1553
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0026 0.0032 0.0071
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0068 0.0201 0.0201
Echinococcus granulosus collagen alpha 1VII chain 0.0046 0.0115 0.0115
Schistosoma mansoni axis inhibition protein axin 0.0038 0.0082 0.0191
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0622 0.2435 0.5398
Loa Loa (eye worm) runx1 0.0056 0.0153 0.034
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0053 0.0141 0.0141
Onchocerca volvulus 0.0046 0.0115 0.0381
Echinococcus granulosus nmda type glutamate receptor 0.0236 0.0879 0.0879
Echinococcus multilocularis sodium:dicarboxylate symporter 0.0111 0.0375 0.0375
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0038 0.0082 0.0191
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.011 0.037 0.082
Treponema pallidum hypothetical protein 0.0046 0.0115 0.017
Loa Loa (eye worm) hypothetical protein 0.0038 0.0082 0.0183
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0026 0.0032 0.0032
Echinococcus granulosus nAChR subunit 0.0026 0.0032 0.0032
Leishmania major trypanothione reductase 0.0048 0.012 0.0942
Onchocerca volvulus 0.0047 0.0117 0.039
Loa Loa (eye worm) hypothetical protein 0.0026 0.0032 0.0071
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0234 0.0871 0.0871
Brugia malayi metabotropic GABA-B receptor subtype 2 0.0145 0.0512 0.139
Loa Loa (eye worm) hypothetical protein 0.0079 0.0248 0.055
Loa Loa (eye worm) RGS-3 protein 0.0038 0.0082 0.0183
Plasmodium vivax SET domain protein, putative 0.0089 0.0287 1
Plasmodium vivax 6-phosphofructokinase, putative 0.0088 0.0284 0.9871
Loa Loa (eye worm) hypothetical protein 0.0026 0.0032 0.0071
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0082 0.0286
Loa Loa (eye worm) RGC/RGC protein kinase 0.0122 0.0421 0.0934
Schistosoma mansoni rab6-interacting 0.002 0.0009 0.0022
Echinococcus granulosus glycine receptor subunit beta 0.0026 0.0032 0.0032
Echinococcus multilocularis lamin 0.011 0.037 0.037
Echinococcus granulosus 6 phosphofructokinase 0.0327 0.1245 0.1245
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0052 0.0179
Echinococcus multilocularis tyrosine kinase 0.0122 0.0421 0.0421
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.01 0.0333 0.077
Loa Loa (eye worm) hypothetical protein 0.0038 0.0082 0.0183
Echinococcus granulosus GPCR family 3 C terminal 0.0145 0.0512 0.0512
Treponema pallidum amino acid ABC transporter, periplasmic binding protein 0.0161 0.0577 0.0872
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0117 0.0319
Brugia malayi Glutamate receptor 1 precursor 0.0111 0.0377 0.1026
Brugia malayi Cation transporter family protein 0.0026 0.0032 0.0087
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0003 0.0006
Loa Loa (eye worm) von Willebrand factor type A domain-containing protein 0.0046 0.0115 0.0255
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0109 0.0366 0.2921
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0076 0.0262
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0039 0.013
Schistosoma mansoni polycystin 1-related 0.002 0.0009 0.0022
Loa Loa (eye worm) glutamate receptor 0.0351 0.1342 0.2977
Schistosoma mansoni nAChR subunit 0.0026 0.0032 0.0074
Echinococcus granulosus neutral amino acid transporter 0.025 0.0936 0.0936
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0038 0.0082 0.0183
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0187 0.1481
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0046 0.0114 0.0263
Echinococcus multilocularis sodium and chloride dependent glycine 0.0079 0.0248 0.0248
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0026 0.0032 0.0032
Loa Loa (eye worm) solute carrier family 6 member 4 0.0079 0.0248 0.055
Echinococcus granulosus nmda type glutamate receptor 0.0122 0.0421 0.0421
Schistosoma mansoni serine/threonine protein kinase 0.0038 0.0082 0.0191
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0026 0.0032 0.0032
Schistosoma mansoni serine/threonine protein kinase 0.0038 0.0082 0.0191
Echinococcus granulosus transcription factor Dp 1 0.0039 0.0086 0.0086
Leishmania major cathepsin L-like protease 0.0064 0.0187 0.1481
Brugia malayi excitatory GABA receptor EXP-1A 0.0026 0.0032 0.0087
Echinococcus granulosus glutamate receptor ionotropic kainate 3 0.0075 0.023 0.023
Onchocerca volvulus Putative nachr subunit 0.0026 0.0032 0.0082
Echinococcus granulosus lamin 0.011 0.037 0.037
Echinococcus multilocularis glutamate receptor 2 0.0234 0.0871 0.0871
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0079 0.0248 0.0675
Echinococcus multilocularis Ankyrin repeat domain containing protein 0.0089 0.0286 0.0286
Schistosoma mansoni sodium/chloride dependent transporter 0.0079 0.0248 0.0574
Onchocerca volvulus 0.0079 0.0248 0.0862
Brugia malayi follicle stimulating hormone receptor 0.0463 0.1797 0.4884
Loa Loa (eye worm) hypothetical protein 0.0079 0.0248 0.055
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0327 0.1245 1
Entamoeba histolytica phosphofructokinase, putative 0.0327 0.1245 1
Echinococcus multilocularis glycine receptor subunit beta 0.0026 0.0032 0.0032
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0079 0.0248 0.0675
Loa Loa (eye worm) hypothetical protein 0.1136 0.451 1
Schistosoma mansoni intermediate filament proteins 0.011 0.037 0.0856
Brugia malayi Cache domain containing protein 0.0503 0.1956 0.5316
Brugia malayi Bloom's syndrome protein homolog 0.0043 0.0103 0.0279
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0037 0.0076 0.0587
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0046 0.0114 0.0892
Echinococcus granulosus regulator of G protein signaling 7 0.0038 0.0082 0.0082
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0036 0.0073 0.0073
Onchocerca volvulus 0.0046 0.0115 0.0381
Echinococcus multilocularis neutral amino acid transporter excitatory amino acid transporter 0.025 0.0936 0.0936
Echinococcus granulosus axis inhibition protein axin 0.0038 0.0082 0.0082
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0026 0.0032 0.0087
Loa Loa (eye worm) hypothetical protein 0.0046 0.0115 0.0255
Echinococcus granulosus Excitatory amino acid transporter 0.025 0.0936 0.0936
Loa Loa (eye worm) hypothetical protein 0.01 0.0331 0.0735
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0166 0.0385
Schistosoma mansoni hypothetical protein 0.0075 0.023 0.0533
Echinococcus granulosus excitatory amino acid transporter 3 0.025 0.0936 0.0936
Schistosoma mansoni lamin 0.011 0.037 0.0856
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0028 0.0091
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.0046 0.0115 0.0404
Plasmodium falciparum glutathione reductase 0.0048 0.012 0.4221
Brugia malayi Immunoglobulin I-set domain containing protein 0.0046 0.0115 0.0312
Plasmodium vivax hypothetical protein, conserved 0.0046 0.0115 0.3939
Plasmodium falciparum von Willebrand factor A domain-related protein 0.0046 0.0115 0.405
Loa Loa (eye worm) hypothetical protein 0.0046 0.0115 0.0255
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0068 0.0201 0.0545
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0026 0.0032 0.0087
Schistosoma mansoni regulator of G protein signaling 0.0038 0.0082 0.0191
Loa Loa (eye worm) hypothetical protein 0.0122 0.0421 0.0934
Schistosoma mansoni regulator of G protein signaling 0.0038 0.0082 0.0191
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0003 0.0098
Brugia malayi Metabotropic glutamate receptor precursor. 0.093 0.3679 1
Loa Loa (eye worm) hypothetical protein 0.0046 0.0115 0.0255
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0068 0.0201 0.0445
Trichomonas vaginalis phosphofructokinase, putative 0.0327 0.1245 0.4472
Echinococcus granulosus Excitatory amino acid transporter 0.025 0.0936 0.0936
Brugia malayi regulator of G-protein signaling egl-10 0.0038 0.0082 0.0224
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0089 0.0287 0.0665
Echinococcus multilocularis axis inhibition protein axin 0.0038 0.0082 0.0082
Loa Loa (eye worm) hypothetical protein 0.0046 0.0115 0.0255
Schistosoma mansoni nAChR subunit 0.0026 0.0032 0.0074
Trypanosoma cruzi cruzipain precursor, putative 0.0064 0.0187 0.1481
Echinococcus granulosus metabotropic glutamate receptor 5 0.1136 0.451 0.451
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0068 0.0201 0.1593
Loa Loa (eye worm) hypothetical protein 0.0038 0.0082 0.0183
Schistosoma mansoni glutamate receptor kainate 0.0111 0.0377 0.0873
Toxoplasma gondii hypothetical protein 0.0079 0.0248 0.8634
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0026 0.0032 0.0032
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0026 0.0032 0.0074
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0028 0.0091
Loa Loa (eye worm) hypothetical protein 0.0038 0.0082 0.0183
Loa Loa (eye worm) hypothetical protein 0.0267 0.1005 0.2228
Loa Loa (eye worm) hypothetical protein 0.0038 0.0082 0.0183
Plasmodium vivax amine transporter, putative 0.0079 0.0248 0.8621
Loa Loa (eye worm) LGC-31 protein 0.0026 0.0032 0.0071
Loa Loa (eye worm) ACC-1 protein 0.0026 0.0032 0.0071
Echinococcus granulosus glycine receptor subunit alpha 1 0.0026 0.0032 0.0032
Schistosoma mansoni glutamate receptor kainate 0.0111 0.0377 0.0873
Onchocerca volvulus 0.011 0.037 0.1301
Brugia malayi von Willebrand factor type A domain containing protein 0.0046 0.0115 0.0312
Echinococcus multilocularis regulator of G protein signaling 7 0.0038 0.0082 0.0082
Onchocerca volvulus Poor gastrulation protein homolog 0.0145 0.0512 0.1812
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0028 0.0091
Loa Loa (eye worm) hypothetical protein 0.0026 0.0032 0.0071
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0026 0.0032 0.0071
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0036 0.0073 0.0566
Brugia malayi PXA domain containing protein 0.0038 0.0082 0.0224
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0023 0.0021 0.0148
Onchocerca volvulus 0.0122 0.0421 0.1486
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0327 0.1245 0.1888
Echinococcus multilocularis Protein lozenge 0.0056 0.0153 0.0153
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0026 0.0032 0.0071
Trichomonas vaginalis phosphofructokinase, putative 0.0327 0.1245 0.4472
Schistosoma mansoni 6-phosphofructokinase 0.0327 0.1245 0.2881
Schistosoma mansoni glutamate receptor AMPA 0.0111 0.0377 0.0873
Echinococcus granulosus survival motor neuron protein 1 0.023 0.0857 0.0857
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0028 0.0091
Loa Loa (eye worm) hypothetical protein 0.0026 0.0032 0.0071
Schistosoma mansoni rab6-interacting 0.002 0.0009 0.0022
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0234 0.0871 0.0871
Onchocerca volvulus 0.0079 0.0248 0.0862
Echinococcus granulosus regulator of G protein signaling 7 0.0038 0.0082 0.0082
Onchocerca volvulus 0.0026 0.0032 0.0082
Entamoeba histolytica hypothetical protein 0.0122 0.0421 0.3367
Trichomonas vaginalis DNA helicase recq, putative 0.0023 0.0021 0.0066
Toxoplasma gondii hypothetical protein 0.0079 0.0248 0.8634
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0088 0.0284 1
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0524 0.2043 0.2043
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0327 0.1245 1
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0046 0.0114 0.0114
Loa Loa (eye worm) hypothetical protein 0.0122 0.0421 0.0934
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0036 0.0073 0.0169
Treponema pallidum 76K protein 0.0046 0.0115 0.017
Echinococcus multilocularis nAChR subunit 0.0026 0.0032 0.0032
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0023 0.0021 0.0148
Loa Loa (eye worm) excitatory amino acid transporter 0.025 0.0936 0.2075
Toxoplasma gondii phosphofructokinase PFKII 0.0088 0.0284 0.9872
Echinococcus granulosus tyrosine kinase 0.0122 0.0421 0.0421
Schistosoma mansoni regulator of G protein signaling 0.0038 0.0082 0.0191
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.0267 0.1005 0.2228
Loa Loa (eye worm) hypothetical protein 0.0026 0.0032 0.0071
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.0166 0.5788
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0109 0.0366 0.2921
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0079 0.0248 0.8634
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0026 0.0032 0.0032
Schistosoma mansoni sodium/chloride dependent transporter 0.0079 0.0248 0.0574
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0023 0.0021 0.0148
Loa Loa (eye worm) hypothetical protein 0.0122 0.0421 0.0934
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0039 0.013
Brugia malayi von Willebrand Factor 0.0046 0.0115 0.0312
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0079 0.0248 0.0574
Brugia malayi phosphofructokinase 0.0327 0.1245 0.3384
Toxoplasma gondii von Willebrand factor type A domain-containing protein 0.0046 0.0115 0.3998
Echinococcus multilocularis atrial natriuretic peptide receptor 0.0122 0.0421 0.0421
Echinococcus granulosus regulator of G protein signaling 3 0.0038 0.0082 0.0082
Loa Loa (eye worm) hypothetical protein 0.0122 0.0421 0.0934
Treponema pallidum sodium- and chloride- dependent transporter 0.0079 0.0248 0.0373
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0327 0.1245 1
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0026 0.0032 0.0074
Brugia malayi von Willebrand factor type A domain containing protein 0.0046 0.0115 0.0312
Onchocerca volvulus 0.0046 0.0115 0.0381
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0036 0.0073 0.0073
Plasmodium vivax dynein-related AAA-type ATPase, putative 0.0046 0.0115 0.3939
Echinococcus multilocularis glycine receptor subunit beta 0.0026 0.0032 0.0032
Loa Loa (eye worm) metabotropic glutamate receptor 8 0.0122 0.0421 0.0934
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0079 0.0248 0.055
Brugia malayi Doublecortin family protein 0.002 0.0009 0.0025
Onchocerca volvulus 0.0046 0.0115 0.0381
Loa Loa (eye worm) PXA domain-containing protein 0.0038 0.0082 0.0183
Brugia malayi hypothetical protein 0.0046 0.0115 0.0312
Trypanosoma cruzi cysteine peptidase, putative 0.0064 0.0187 0.1481
Schistosoma mansoni hypothetical protein 0.0145 0.0512 0.1184
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0187 0.1481
Schistosoma mansoni loxhd1 0.002 0.0009 0.0022
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0026 0.0032 0.0032
Loa Loa (eye worm) glutamate receptor 0.093 0.3679 0.8157
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0073 0.0566
Trypanosoma cruzi cysteine peptidase, putative 0.0064 0.0187 0.1481
Plasmodium vivax hypothetical protein, conserved 0.0079 0.0248 0.8621
Brugia malayi M-phase phosphoprotein, mpp8 0.01 0.0331 0.0901
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0028 0.0091
Loa Loa (eye worm) hypothetical protein 0.0051 0.0133 0.0295
Entamoeba histolytica hypothetical protein 0.0046 0.0115 0.0902
Echinococcus granulosus axis inhibition protein axin 0.0038 0.0082 0.0082
Schistosoma mansoni sodium/dicarboxylate symporter-related 0.0111 0.0375 0.0867
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0122 0.0421 0.0934
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0187 0.1481
Trichomonas vaginalis phosphofructokinase, putative 0.0088 0.0284 0.1011
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0026 0.0032 0.0032
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0079 0.0248 0.8634
Plasmodium falciparum thioredoxin reductase 0.0048 0.012 0.4221
Brugia malayi hypothetical protein 0.0446 0.1725 0.469
Trypanosoma cruzi cysteine peptidase, putative 0.0064 0.0187 0.1481
Loa Loa (eye worm) norepinephrine transporter 0.0079 0.0248 0.055
Brugia malayi Regulator of G protein signaling domain containing protein 0.0038 0.0082 0.0224
Entamoeba histolytica recQ family helicase, putative 0.0023 0.0021 0.0148
Loa Loa (eye worm) hypothetical protein 0.0026 0.0032 0.0071
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0088 0.0284 0.0517
Schistosoma mansoni nAChR subunit 0.0026 0.0032 0.0074
Onchocerca volvulus 0.0707 0.2781 1
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0029 0.0046 0.1519
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0036 0.0073 0.0073
Entamoeba histolytica hypothetical protein 0.0038 0.0082 0.064
Loa Loa (eye worm) ACC-1 protein 0.0026 0.0032 0.0071
Echinococcus multilocularis lamin dm0 0.011 0.037 0.037
Echinococcus granulosus glutamate receptor 2 0.0234 0.0871 0.0871
Schistosoma mansoni lamin 0.011 0.037 0.0856
Giardia lamblia GTOR 0.0046 0.0114 0.4002
Onchocerca volvulus 0.0026 0.0032 0.0082
Schistosoma mansoni tyrosine kinase 0.0122 0.0421 0.0974
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0068 0.0201 0.1593
Echinococcus multilocularis musashi 0.011 0.037 0.037
Loa Loa (eye worm) von Willebrand factor domain-containing protein 0.0046 0.0115 0.0255
Trichomonas vaginalis phosphofructokinase, putative 0.0088 0.0284 0.1011
Loa Loa (eye worm) hypothetical protein 0.0079 0.0248 0.055
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0066 0.0227
Schistosoma mansoni nAChR subunit 0.0026 0.0032 0.0074
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0046 0.0114 0.0114
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0524 0.2043 0.2043
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0028 0.0091
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0046 0.0114 0.0892
Echinococcus multilocularis receptor type guanylyl cyclase 0.0122 0.0421 0.0421
Echinococcus multilocularis Polycystic kidney disease protein 0.002 0.0009 0.0009
Leishmania major extracellular receptor, putative 0.0122 0.0421 0.3367
Loa Loa (eye worm) glutamate receptor 2 0.0111 0.0377 0.0837
Loa Loa (eye worm) hypothetical protein 0.0035 0.0067 0.0149
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0187 0.1481
Schistosoma mansoni blooms syndrome DNA helicase 0.0034 0.0066 0.0152
Loa Loa (eye worm) glutamate receptor 1 0.0111 0.0377 0.0837
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0187 0.1481
Echinococcus granulosus ubiquitin specific protease 41 0.0036 0.0073 0.0073
Echinococcus granulosus serotonin transporter 0.0079 0.0248 0.0248
Echinococcus multilocularis geminin 0.0174 0.0628 0.0628
Trichomonas vaginalis PIKK family atypical protein kinase 0.0046 0.0114 0.0399
Brugia malayi Intermediate filament tail domain containing protein 0.011 0.037 0.1006
Echinococcus granulosus excitatory amino acid transporter 2 0.025 0.0936 0.0936
Loa Loa (eye worm) hypothetical protein 0.0046 0.0115 0.0255
Echinococcus multilocularis glutamate receptor 2 0.0159 0.0568 0.0568
Loa Loa (eye worm) hypothetical protein 0.0026 0.0032 0.0071
Loa Loa (eye worm) hypothetical protein 0.0026 0.0032 0.0071
Loa Loa (eye worm) CUTiclin family member 0.0046 0.0115 0.0255
Schistosoma mansoni ap endonuclease 0.0019 0.0003 0.0006
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0187 0.1481
Onchocerca volvulus 0.0026 0.0032 0.0082
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0039 0.013
Mycobacterium tuberculosis Probable oxidoreductase 0.0121 0.0414 0.3314
Loa Loa (eye worm) RGC/RGC protein kinase 0.0122 0.0421 0.0934
Brugia malayi von Willebrand factor type A domain containing protein 0.0046 0.0115 0.0312
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0079 0.0248 0.8634
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0037 0.0076 0.0587
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0524 0.2043 0.4728
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0026 0.0032 0.0071
Brugia malayi Thioredoxin reductase 0.0048 0.012 0.0326
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0026 0.0032 0.0087
Plasmodium vivax glutathione reductase, putative 0.0048 0.012 0.411
Echinococcus granulosus glutamate receptor subunit protein glur 0.0075 0.023 0.023
Trypanosoma brucei trypanothione reductase 0.0048 0.012 0.0942
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0003 0.0098
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0059 0.0166 0.1316
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0026 0.0032 0.0032
Loa Loa (eye worm) hypothetical protein 0.0026 0.0032 0.0071
Loa Loa (eye worm) hypothetical protein 0.002 0.0009 0.0021
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0026 0.0032 0.0087
Loa Loa (eye worm) hypothetical protein 0.0046 0.0115 0.0255
Echinococcus multilocularis nmda type glutamate receptor 0.0236 0.0879 0.0879
Brugia malayi Cytochrome P450 family protein 0.0023 0.0021 0.0058
Echinococcus multilocularis collagen alpha 1(VII) chain 0.0046 0.0115 0.0115
Toxoplasma gondii thioredoxin reductase 0.0048 0.012 0.4167
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0079 0.0248 0.0574
Trichomonas vaginalis DNA helicase recq1, putative 0.0043 0.0103 0.0359
Echinococcus granulosus excitatory amino acid transporter 2 0.025 0.0936 0.0936
Schistosoma mansoni multiple ankyrin repeats single kh domain protein 0.0089 0.0286 0.0662
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0079 0.0248 0.0248
Schistosoma mansoni sodium/chloride dependent transporter 0.0079 0.0248 0.0574
Trichomonas vaginalis phosphofructokinase, putative 0.0088 0.0284 0.1011
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0073 0.0253
Echinococcus multilocularis Ribosomal protein S1, RNA binding domain 0.0075 0.023 0.023
Plasmodium falciparum circumsporozoite- and TRAP-related protein 0.0046 0.0115 0.405
Schistosoma mansoni 6-phosphofructokinase 0.0327 0.1245 0.2881
Loa Loa (eye worm) hypothetical protein 0.0026 0.0032 0.0071
Echinococcus multilocularis excitatory amino acid transporter 2 0.025 0.0936 0.0936
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0026 0.0032 0.0032
Trichomonas vaginalis DNA helicase recq, putative 0.0043 0.0103 0.0359
Loa Loa (eye worm) hypothetical protein 0.0079 0.0248 0.055
Echinococcus granulosus glycine receptor subunit alpha 1 0.0026 0.0032 0.0032
Trichomonas vaginalis PIKK family atypical protein kinase 0.0046 0.0114 0.0399
Chlamydia trachomatis arginine ABC transporter substrate-binding protein ArtJ 0.0161 0.0577 0.4781
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0327 0.1245 1
Brugia malayi metabotropic glutamate receptor type 2 0.0473 0.1836 0.499
Echinococcus granulosus glutamate receptor 2 0.0159 0.0568 0.0568
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0234 0.0871 0.0871
Loa Loa (eye worm) hypothetical protein 0.0036 0.0073 0.0162
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0463 0.1797 0.3984
Echinococcus granulosus geminin 0.0174 0.0628 0.0628
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0089 0.0287 1
Onchocerca volvulus 0.0079 0.0248 0.0862
Loa Loa (eye worm) hypothetical protein 0.0046 0.0115 0.0255
Loa Loa (eye worm) hypothetical protein 0.011 0.037 0.082
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0046 0.0114 0.0892
Toxoplasma gondii 6-phosphofructokinase 0.0088 0.0284 0.9872
Onchocerca volvulus Atrial natriuretic peptide receptor 3 homolog 0.0122 0.0421 0.1486
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0068 0.0201 0.0201
Brugia malayi von Willebrand factor type A domain containing protein 0.0046 0.0115 0.0312
Echinococcus multilocularis glutamate receptor 2 0.0111 0.0377 0.0377
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0048 0.0164
Schistosoma mansoni hypothetical protein 0.0046 0.0115 0.0266
Leishmania major cathepsin L-like protease 0.0064 0.0187 0.1481
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0088 0.0284 0.0517
Entamoeba histolytica hypothetical protein, conserved 0.0046 0.0115 0.0902
Onchocerca volvulus 0.0046 0.0115 0.0381
Brugia malayi von Willebrand factor type A domain containing protein 0.0046 0.0115 0.0312
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0038 0.0082 0.0082
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0057 0.0156 0.0156
Echinococcus granulosus glycine receptor subunit beta 0.0026 0.0032 0.0032
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0073 0.0566
Echinococcus multilocularis serotonin transporter 0.0079 0.0248 0.0248
Loa Loa (eye worm) hypothetical protein 0.0446 0.1725 0.3826
Echinococcus multilocularis Excitatory amino acid transporter 0.025 0.0936 0.0936
Echinococcus granulosus receptor type guanylyl cyclase 0.0122 0.0421 0.0421
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0079 0.0248 0.0675
Loa Loa (eye worm) 6-phosphofructokinase 0.0327 0.1245 0.2761
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0026 0.0032 0.0032
Mycobacterium tuberculosis Probable dehydrogenase 0.0109 0.0366 0.2921
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0088 0.0284 0.9872
Trypanosoma cruzi extracellular receptor, putative 0.0122 0.0421 0.3367
Trichomonas vaginalis phosphofructokinase, putative 0.0088 0.0284 0.1011
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0059 0.0166 0.1316
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0046 0.0114 0.0892
Brugia malayi hypothetical protein 0.023 0.0857 0.2328
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0038 0.0082 0.0224
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0111 0.0377 0.0377
Chlamydia trachomatis glutamine binding protein 0.0161 0.0577 0.4781
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0026 0.0032 0.0087
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0036 0.0073 0.0073
Loa Loa (eye worm) hypothetical protein 0.0446 0.1725 0.3826
Mycobacterium tuberculosis Probable reductase 0.0109 0.0366 0.2921
Echinococcus granulosus Ankyrin repeat domain containing protein 0.0089 0.0286 0.0286
Schistosoma mansoni sodium-dependent amino acid transporter 0.0079 0.0248 0.0574
Loa Loa (eye worm) serotonin transporter b 0.0079 0.0248 0.055
Schistosoma mansoni glutamate receptor AMPA 0.0111 0.0377 0.0873
Schistosoma mansoni regulator of G protein signaling 0.0038 0.0082 0.0191
Onchocerca volvulus 0.0446 0.1725 0.6192
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0234 0.0871 0.0871
Echinococcus multilocularis thioredoxin glutathione reductase 0.0048 0.012 0.012
Loa Loa (eye worm) hypothetical protein 0.0122 0.0421 0.0934
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0068 0.0201 0.1593
Toxoplasma gondii microneme protein MIC2 0.0046 0.0115 0.3998
Loa Loa (eye worm) hypothetical protein 0.0026 0.0032 0.0071
Echinococcus granulosus neutral amino acid transporter A 0.025 0.0936 0.0936
Echinococcus granulosus neutral amino acid transporter A 0.025 0.0936 0.0936
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) 0.1014 0.4017 0.9294
Echinococcus multilocularis expressed protein 0.0746 0.2936 0.2936
Brugia malayi Excitatory amino acid transporter 0.025 0.0936 0.2543
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0066 0.0227
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0121 0.0414 0.3314
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0088 0.0284 0.0427
Echinococcus multilocularis survival motor neuron protein 1 0.023 0.0857 0.0857
Echinococcus granulosus sodium and chloride dependent glycine 0.0079 0.0248 0.0248
Toxoplasma gondii target of rapamycin (TOR), putative 0.0034 0.0066 0.2295
Schistosoma mansoni dihydropyridine-sensitive l-type calcium channel 0.0549 0.2143 0.4958
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0038 0.0081 0.2869
Loa Loa (eye worm) hypothetical protein 0.0122 0.0421 0.0934
Brugia malayi glutathione reductase 0.0048 0.012 0.0326
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0089 0.0287 0.0287
Plasmodium vivax multidomain scavenger receptor, putative 0.002 0.0009 0.023
Trypanosoma cruzi major cysteine proteinase, putative 0.005 0.0131 0.1035
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0079 0.0248 0.0675
Schistosoma mansoni survival motor neuron protein 0.0047 0.0117 0.0271
Echinococcus multilocularis voltage dependent calcium channel subunit 0.2497 1 1
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0036 0.0073 0.0253
Echinococcus granulosus bloom syndrome protein 0.0043 0.0103 0.0103
Echinococcus multilocularis Excitatory amino acid transporter 0.025 0.0936 0.0936
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0026 0.0032 0.0074
Loa Loa (eye worm) hypothetical protein 0.0046 0.0115 0.0255
Schistosoma mansoni glutamate receptor NMDA 0.0111 0.0377 0.0873
Entamoeba histolytica phosphofructokinase, putative 0.0327 0.1245 1
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0059 0.0164 0.13
Trypanosoma cruzi target of rapamycin kinase 3 0.0037 0.0076 0.0587
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0026 0.0032 0.0087
Schistosoma mansoni dihydropyridine-sensitive l-type calcium channel 0.1089 0.4322 1
Onchocerca volvulus 0.01 0.0331 0.1162
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0079 0.0248 0.0248
Loa Loa (eye worm) hypothetical protein 0.0038 0.0082 0.0183
Schistosoma mansoni lipoxygenase 0.002 0.0009 0.0022
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0524 0.2043 0.4728
Brugia malayi Cation transporter family protein 0.0026 0.0032 0.0087
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0026 0.0032 0.0087
Echinococcus multilocularis NMDA receptor 0.0075 0.023 0.023
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0038 0.0082 0.0191
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0046 0.0115 0.0312
Loa Loa (eye worm) hypothetical protein 0.0145 0.0512 0.1134
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0026 0.0032 0.0032
Loa Loa (eye worm) hypothetical protein 0.0108 0.0362 0.0802
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0036 0.0073 0.0169
Echinococcus multilocularis RUN 0.002 0.0009 0.0009
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0079 0.0248 0.0248
Trichomonas vaginalis phosphofructokinase, putative 0.0088 0.0284 0.1011
Schistosoma mansoni regulator of G protein signaling 0.0038 0.0082 0.0191
Echinococcus granulosus lamin dm0 0.011 0.037 0.037
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0036 0.0073 0.0253
Loa Loa (eye worm) thioredoxin reductase 0.0048 0.012 0.0266
Loa Loa (eye worm) glutathione reductase 0.0048 0.012 0.0266
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0079 0.0248 0.0574
Brugia malayi hypothetical protein 0.0079 0.0248 0.0675
Plasmodium falciparum LCCL domain-containing protein 0.002 0.0009 0.0329
Echinococcus granulosus thioredoxin glutathione reductase 0.0048 0.012 0.012
Schistosoma mansoni nAChR subunit 0.0026 0.0032 0.0074
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0059 0.0165 0.0365
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0187 0.1481
Schistosoma mansoni nAChR subunit 0.0026 0.0032 0.0074
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0038 0.0082 0.0286
Brugia malayi PXA domain containing protein 0.0038 0.0082 0.0224
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0076 0.0262
Entamoeba histolytica hypothetical protein 0.0038 0.0082 0.064
Brugia malayi hypothetical protein 0.002 0.0009 0.0025
Echinococcus granulosus Polycystic kidney disease protein 0.002 0.0009 0.0009
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0076 0.0262
Echinococcus multilocularis beta adrenergic receptor kinase 0.0038 0.0082 0.0082
Onchocerca volvulus 0.01 0.0333 0.1167
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0082 0.0286
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0079 0.0248 0.0248
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0066 0.0227
Brugia malayi intermediate filament protein 0.011 0.037 0.1006
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0053 0.0141 0.0141
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0026 0.0032 0.0087
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0048 0.012 0.0942
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0026 0.0032 0.0087
Echinococcus multilocularis 6 phosphofructokinase 0.0327 0.1245 0.1245
Schistosoma mansoni hypothetical protein 0.0047 0.0117 0.0271
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0038 0.0126
Echinococcus multilocularis regulator of G protein signaling 3 0.0038 0.0082 0.0082
Onchocerca volvulus 0.0026 0.0032 0.0082
Treponema pallidum amino acid ABC transporter, periplasmic binding protein (hisJ) 0.0161 0.0577 0.0872
Mycobacterium tuberculosis Probable C4-dicarboxylate-transport transmembrane protein DctA 0.025 0.0936 0.7509
Echinococcus granulosus sodium:dicarboxylate symporter 0.025 0.0936 0.0936
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0234 0.0871 0.0871
Onchocerca volvulus 0.0046 0.0115 0.0381
Loa Loa (eye worm) hypothetical protein 0.0503 0.1956 0.4337
Trichomonas vaginalis phosphofructokinase, putative 0.0327 0.1245 0.4472
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0073 0.0566
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0068 0.0201 0.0464
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0082 0.0286
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0026 0.0032 0.0087
Brugia malayi hypothetical protein 0.01 0.0331 0.0901
Echinococcus multilocularis regulator of G protein signaling 3 0.0038 0.0082 0.0082
Loa Loa (eye worm) hypothetical protein 0.0046 0.0115 0.0255
Loa Loa (eye worm) hypothetical protein 0.0026 0.0032 0.0071
Loa Loa (eye worm) hypothetical protein 0.0026 0.0032 0.0071
Loa Loa (eye worm) hypothetical protein 0.01 0.0331 0.0735
Schistosoma mansoni ATP-binding cassette transporter 0.0111 0.0377 0.0873
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.0166 0.0166
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0089 0.0287 0.0287
Echinococcus granulosus metabotropic glutamate receptor 2 0.0785 0.3095 0.3095
Loa Loa (eye worm) hypothetical protein 0.0046 0.0115 0.0255
Loa Loa (eye worm) hypothetical protein 0.0026 0.0032 0.0071
Echinococcus multilocularis regulator of G protein signaling 0.0038 0.0082 0.0082
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0079 0.0248 0.0574
Echinococcus granulosus sodium and chloride dependent glycine 0.0079 0.0248 0.0248
Trichomonas vaginalis phosphofructokinase, putative 0.0088 0.0284 0.1011
Loa Loa (eye worm) phosphofructokinase 0.0327 0.1245 0.2761
Schistosoma mansoni lipoxygenase 0.0057 0.0156 0.0361
Loa Loa (eye worm) hypothetical protein 0.0026 0.0032 0.0071
Treponema pallidum methyl-accepting chemotaxis protein (mcp2-1) 0.165 0.6584 1
Brugia malayi Cation transporter family protein 0.0026 0.0032 0.0087
Echinococcus multilocularis excitatory amino acid transporter 2 0.025 0.0936 0.0936
Loa Loa (eye worm) CUTiclin-Like family member 0.0046 0.0115 0.0255
Echinococcus multilocularis transcription factor Dp 1 0.0039 0.0086 0.0086
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0076 0.0262
Schistosoma mansoni glutamate receptor NMDA 0.0234 0.0871 0.2014
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.0161 0.0577 0.4621
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0187 0.1481
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0057 0.0156 0.0156
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0026 0.0032 0.0071
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0079 0.0248 0.0574
Echinococcus multilocularis glutamate receptor ionotropic kainate 0.0075 0.023 0.023
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0079 0.0248 0.055
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0086 0.0301
Trichomonas vaginalis set domain proteins, putative 0.0707 0.2781 1
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0234 0.0871 0.0871
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0088 0.0284 1
Loa Loa (eye worm) 6-phosphofructokinase 0.0327 0.1245 0.2761
Schistosoma mansoni metabotropic glutamate receptor 0.0785 0.3095 0.7162
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0082 0.0286
Plasmodium vivax thrombospondin-related anonymous protein 0.0046 0.0115 0.3939
Loa Loa (eye worm) hypothetical protein 0.002 0.0009 0.0021
Loa Loa (eye worm) doublecortin family protein 0.002 0.0009 0.0021
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.0267 0.1005 0.2228
Loa Loa (eye worm) hypothetical protein 0.0524 0.2043 0.453
Loa Loa (eye worm) hypothetical protein 0.0079 0.0248 0.055
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0026 0.0032 0.0032
Loa Loa (eye worm) hypothetical protein 0.0079 0.0248 0.055
Brugia malayi hypothetical protein 0.0038 0.0082 0.0224
Schistosoma mansoni tyrosine kinase 0.0122 0.0421 0.0974
Onchocerca volvulus 0.0026 0.0032 0.0082
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0026 0.0032 0.0087
Echinococcus granulosus regulator of G protein signaling 3 0.0038 0.0082 0.0082
Trichomonas vaginalis PIKK family atypical protein kinase 0.0046 0.0114 0.0399
Loa Loa (eye worm) hypothetical protein 0.0026 0.0032 0.0071
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0009 0.0009
Echinococcus multilocularis axis inhibition protein axin 0.0038 0.0082 0.0082
Echinococcus granulosus intermediate filament protein 0.011 0.037 0.037
Schistosoma mansoni serine/threonine protein kinase 0.0038 0.0082 0.0191
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0038 0.0082 0.0183
Echinococcus granulosus expressed protein 0.0746 0.2936 0.2936
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0026 0.0032 0.0087
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0068 0.0201 0.1593
Echinococcus granulosus beta-adrenergic receptor kinase 0.0038 0.0082 0.0082
Loa Loa (eye worm) intermediate filament protein 0.011 0.037 0.082
Schistosoma mansoni multiple ankyrin repeats single kh domain protein 0.0089 0.0286 0.0662
Echinococcus granulosus atrial natriuretic peptide receptor 0.0122 0.0421 0.0421
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0009 0.0009
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0026 0.0032 0.0032
Loa Loa (eye worm) hypothetical protein 0.0046 0.0115 0.0255
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0046 0.0114 0.0892
Chlamydia trachomatis glutamate symporter 0.025 0.0936 1
Brugia malayi Guanylyl cyclase protein 23 0.0122 0.0421 0.1145
Loa Loa (eye worm) hypothetical protein 0.0051 0.0133 0.0295
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0109 0.0366 0.2921
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0086 0.0274 0.0274
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0036 0.0073 0.2576
Loa Loa (eye worm) hypothetical protein 0.0524 0.2043 0.453
Brugia malayi 6-phosphofructokinase 0.0327 0.1245 0.3384
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0018 0.000000000032858 0.0000000011433
Schistosoma mansoni lozenge 0.0056 0.0153 0.0355
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0026 0.0032 0.0087
Plasmodium falciparum thrombospondin-related anonymous protein 0.0046 0.0115 0.405
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0028 0.0091
Brugia malayi von Willebrand factor type A domain containing protein 0.0046 0.0115 0.0312
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0036 0.0073 0.0199
Schistosoma mansoni metabotropic glutamate receptor 0.0473 0.1836 0.4248
Entamoeba histolytica hypothetical protein, conserved 0.0046 0.0115 0.0902
Echinococcus granulosus glycine receptor subunit alpha 1 0.0026 0.0032 0.0032
Echinococcus granulosus Regulator of G protein signaling 20 0.0038 0.0082 0.0082
Schistosoma mansoni hypothetical protein 0.002 0.0009 0.0022
Loa Loa (eye worm) phosphatidylinositol 3 0.0046 0.0114 0.0252
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0026 0.0032 0.0074
Mycobacterium ulcerans 6-phosphofructokinase 0.0327 0.1245 1
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0166 0.0385
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0068 0.0201 0.1593
Schistosoma mansoni hypothetical protein 0.0174 0.0628 0.1453
Loa Loa (eye worm) hypothetical protein 0.0046 0.0115 0.0255
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0026 0.0032 0.0087
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0026 0.0032 0.0087
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0022 0.0016 0.0104
Echinococcus multilocularis GPCR, family 3, C terminal 0.0145 0.0512 0.0512
Echinococcus multilocularis ubiquitin specific protease 41 0.0036 0.0073 0.0073
Echinococcus granulosus voltage dependent calcium channel subunit 0.1136 0.4509 0.4509
Schistosoma mansoni hypothetical protein 0.0046 0.0115 0.0266
Onchocerca volvulus 0.01 0.0331 0.1162
Echinococcus multilocularis voltage dependent calcium channel subunit 0.1136 0.4509 0.4509
Echinococcus multilocularis bloom syndrome protein 0.0043 0.0103 0.0103
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0166 0.1316
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0026 0.0032 0.0032
Leishmania major cathepsin L-like protease 0.0064 0.0187 0.1481
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0046 0.0114 0.0892
Echinococcus multilocularis Regulator of G protein signaling 20 0.0038 0.0082 0.0082
Plasmodium falciparum amino acid transporter, putative 0.0079 0.0248 0.8746
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0066 0.0227
Trypanosoma cruzi trypanothione reductase, putative 0.0048 0.012 0.0942
Entamoeba histolytica phosphofructokinase, putative 0.0327 0.1245 1
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.0166 0.0166
Schistosoma mansoni z-protein (S1r protein) 0.0038 0.0082 0.0191
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0079 0.0248 0.0574
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0236 0.0879 0.0879
Loa Loa (eye worm) hypothetical protein 0.0313 0.1192 0.2643
Plasmodium vivax circumsporozoite- and TRAP-related protein, putative 0.0046 0.0115 0.3939
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0234 0.0871 0.0871
Echinococcus multilocularis sodium and chloride dependent glycine 0.0079 0.0248 0.0248
Schistosoma mansoni serine-rich repeat protein 0.0587 0.2294 0.5308
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0066 0.0227
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0026 0.0032 0.0071
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0524 0.2043 0.4728
Echinococcus granulosus glutamate NMDA receptor subunit 0.0111 0.0377 0.0377
Brugia malayi hypothetical protein 0.002 0.0009 0.0025
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0082 0.0286
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0026 0.0032 0.0032
Brugia malayi hypothetical protein 0.0038 0.0082 0.0224
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0026 0.0032 0.0074
Schistosoma mansoni protein kinase 0.0122 0.0421 0.0974
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0785 0.3095 0.3095
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0038 0.0082 0.0183
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0066 0.0227
Loa Loa (eye worm) hypothetical protein 0.0053 0.0141 0.0313
Brugia malayi Zona pellucida-like domain containing protein 0.0046 0.0115 0.0312
Loa Loa (eye worm) hypothetical protein 0.0089 0.0287 0.0637
Onchocerca volvulus 0.0046 0.0115 0.0381
Loa Loa (eye worm) hypothetical protein 0.0026 0.0032 0.0071
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0003 0.0003
Brugia malayi A-kinase anchor protein 10, precursor 0.0038 0.0082 0.0224
Brugia malayi von Willebrand factor type A domain containing protein 0.0046 0.0115 0.0312
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0026 0.0032 0.0032
Echinococcus multilocularis metabotropic glutamate receptor 5 0.1136 0.451 0.451
Entamoeba histolytica elongation factor-2 kinase, putative 0.0046 0.0115 0.0902
Echinococcus multilocularis neutral amino acid transporter A 0.025 0.0936 0.0936
Plasmodium vivax 6-phosphofructokinase, putative 0.0088 0.0284 0.9871
Echinococcus granulosus glutamate receptor ionotropic kainate 0.0075 0.023 0.023
Brugia malayi Regulator of G protein signaling domain containing protein 0.0038 0.0082 0.0224
Brugia malayi hypothetical protein 0.0122 0.0421 0.1145
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0038 0.0082 0.0191
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0121 0.0414 0.0555
Plasmodium vivax thioredoxin reductase, putative 0.0048 0.012 0.411
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0082 0.0286
Brugia malayi cytoplasmic intermediate filament protein 0.0059 0.0165 0.0448
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0026 0.0032 0.0074
Loa Loa (eye worm) hypothetical protein 0.0046 0.0115 0.0255
Onchocerca volvulus 0.0122 0.0421 0.1486
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0038 0.0082 0.0082
Plasmodium vivax von Willebrand factor A domain-related protein, putative 0.0046 0.0115 0.3939
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0036 0.0073 0.0566
Loa Loa (eye worm) RGC/RGC protein kinase 0.0122 0.0421 0.0934
Brugia malayi 6-phosphofructokinase 0.0327 0.1245 0.3384
Trichomonas vaginalis phosphofructokinase, putative 0.0327 0.1245 0.4472
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.0161 0.0577 0.4621
Echinococcus granulosus Ribosomal protein S1 RNA binding domain 0.0075 0.023 0.023
Onchocerca volvulus 0.011 0.037 0.1301
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0166 0.1316
Schistosoma mansoni solute carrier family 1 (glial high affinity glutamate transporter 0.025 0.0936 0.2165
Leishmania major ATP-dependent phosphofructokinase 0.0327 0.1245 1
Toxoplasma gondii exonuclease III APE 0.0019 0.0003 0.0097
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0003 0.0008
Onchocerca volvulus Excitatory amino acid transporter homolog 0.025 0.0936 0.3342
Echinococcus multilocularis nmda type glutamate receptor 0.0122 0.0421 0.0421
Loa Loa (eye worm) hypothetical protein 0.0026 0.0032 0.0071
Echinococcus multilocularis neutral amino acid transporter excitatory amino acid transporter 0.0111 0.0375 0.0375
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0046 0.0114 0.0309
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0088 0.0284 0.1011
Schistosoma mansoni hypothetical protein 0.0174 0.0628 0.1453
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0079 0.0248 0.0248
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0187 0.1481
Echinococcus multilocularis sodium:dicarboxylate symporter 0.025 0.0936 0.0936
Plasmodium falciparum transporter, putative 0.0079 0.0248 0.8746
Brugia malayi metabotropic glutamate receptor subtype 5a (mGluR5a), putative 0.0808 0.3186 0.8659
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0187 0.1481
Schistosoma mansoni hypothetical protein 0.0587 0.2294 0.5308
Echinococcus multilocularis neutral amino acid transporter A 0.025 0.0936 0.0936
Echinococcus multilocularis neutral amino acid transporter A 0.025 0.0936 0.0936
Onchocerca volvulus 0.0079 0.0248 0.0862
Loa Loa (eye worm) hypothetical protein 0.0026 0.0032 0.0071
Loa Loa (eye worm) hypothetical protein 0.023 0.0857 0.1899
Echinococcus multilocularis glutamate receptor subunit protein glur 0.0075 0.023 0.023
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0026 0.0032 0.0032
Loa Loa (eye worm) hypothetical protein 0.0079 0.0248 0.055
Loa Loa (eye worm) cytochrome P450 family protein 0.0023 0.0021 0.0047
Onchocerca volvulus Metabotropic glutamate receptor homolog 0.0145 0.0512 0.1812
Echinococcus multilocularis regulator of G protein signaling 7 0.0038 0.0082 0.0082
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0026 0.0032 0.0087
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0079 0.0248 0.055
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0066 0.0227
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0234 0.0871 0.0871
Echinococcus multilocularis excitatory amino acid transporter 3 0.025 0.0936 0.0936
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0121 0.0414 0.3314
Echinococcus granulosus RUN 0.002 0.0009 0.0009
Brugia malayi Receptor family ligand binding region containing protein 0.0122 0.0421 0.1145
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0019 0.0005 0.0018
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0076 0.0262
Schistosoma mansoni sodium/dicarboxylate symporter-related 0.0111 0.0375 0.0867
Brugia malayi Glutamate receptor 2 precursor 0.0111 0.0377 0.1026
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0079 0.0248 0.0675
Schistosoma mansoni nAChR subunit 0.0026 0.0032 0.0074
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0089 0.0287 0.0665
Brugia malayi Pre-SET motif family protein 0.0089 0.0287 0.0781

Activities

Activity type Activity value Assay description Source Reference
logP (ADMET) = 1.31 Partition coefficient (logP) ChEMBL. 10346935

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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