Detailed information for compound 817654

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 441.59 | Formula: C23H31N5O2S
  • H donors: 1 H acceptors: 4 LogP: 2.79 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CSc1ccc(cc1)C(=O)N1CCc2n(CC1)c(nn2)CCNC(=O)C1CCCCC1
  • InChi: 1S/C23H31N5O2S/c1-31-19-9-7-18(8-10-19)23(30)27-14-12-21-26-25-20(28(21)16-15-27)11-13-24-22(29)17-5-3-2-4-6-17/h7-10,17H,2-6,11-16H2,1H3,(H,24,29)
  • InChiKey: JJJLLNNDHGGEGQ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Cytochrome P450 family protein 0.0028 0.0041 0.0041
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0029 0.0046 0.0038
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0042 0.0104 0.0096
Onchocerca volvulus Cytochrome c oxidase subunit 2 homolog 0.0046 0.0127 0.0119
Loa Loa (eye worm) cytochrome P450 family protein 0.0079 0.0274 0.0274
Schistosoma mansoni cell polarity protein 0.0392 0.1697 0.169
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0042 0.0108 0.01
Echinococcus multilocularis microsomal glutathione S transferase 3 0.0115 0.044 0.0432
Toxoplasma gondii MAPEG family protein 0.0115 0.044 0.1602
Brugia malayi Cadherin domain containing protein 0.0392 0.1697 0.1697
Loa Loa (eye worm) CYP4Cod1 0.0028 0.0041 0.0041
Echinococcus multilocularis FTZ F1 alpha 0.0029 0.0046 0.0038
Brugia malayi EGF-like domain containing protein 0.0392 0.1697 0.1697
Echinococcus granulosus voltage dependent calcium channel 0.0042 0.0104 0.0096
Loa Loa (eye worm) hypothetical protein 0.0545 0.2389 0.2389
Onchocerca volvulus Slit protein homolog 0.0392 0.1697 0.169
Onchocerca volvulus Peroxidasin homolog 0.2221 1 1
Onchocerca volvulus 0.0042 0.0108 0.01
Brugia malayi P38 map kinase family protein 2 0.0132 0.0516 0.0516
Echinococcus granulosus carbonic anhydrase II 0.1127 0.5033 0.5029
Echinococcus multilocularis carbonic anhydrase II 0.1127 0.5033 0.5029
Loa Loa (eye worm) doublecortin family protein 0.002 0.0008 0.0008
Trichomonas vaginalis AGC family protein kinase 0.0247 0.1035 0.127
Loa Loa (eye worm) hypothetical protein 0.0249 0.1048 0.1048
Schistosoma mansoni hypothetical protein 0.0392 0.1697 0.169
Brugia malayi EGF-like domain containing protein 0.0392 0.1697 0.1697
Giardia lamblia High cysteine protein 0.0392 0.1697 0.5
Loa Loa (eye worm) hypothetical protein 0.0029 0.0046 0.0046
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0029 0.0046 0.0038
Plasmodium falciparum carbonic anhydrase 0.0545 0.2389 1
Trichomonas vaginalis conserved hypothetical protein 0.1461 0.655 1
Schistosoma mansoni thyroid hormone receptor 0.0159 0.0636 0.0628
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.013 0.0505 0.0498
Loa Loa (eye worm) hypothetical protein 0.0042 0.0108 0.0108
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0042 0.0108 0.0108
Loa Loa (eye worm) hypothetical protein 0.2221 1 1
Brugia malayi Cytochrome P450 family protein 0.0079 0.0274 0.0274
Onchocerca volvulus Cytochrome c oxidase subunit 2 homolog 0.0046 0.0127 0.0119
Onchocerca volvulus 0.2221 1 1
Mycobacterium tuberculosis Probable transmembrane cytochrome C oxidase (subunit II) CtaC 0.0046 0.0127 0.005
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0042 0.0108 0.0172
Loa Loa (eye worm) hypothetical protein 0.0392 0.1697 0.1697
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.1127 0.5033 1
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0042 0.0108 0.0108
Brugia malayi Putative carbonic anhydrase 5 precursor 0.1127 0.5033 0.5033
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0029 0.0046 0.0038
Loa Loa (eye worm) calcium channel 0.0042 0.0104 0.0104
Echinococcus granulosus sodium and chloride dependent glycine 0.0042 0.0108 0.01
Schistosoma mansoni laminin gamma-3 chain 0.0392 0.1697 0.169
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0029 0.0046 0.0038
Schistosoma mansoni hypothetical protein 0.0392 0.1697 0.169
Echinococcus multilocularis neural cadherin 0.0392 0.1697 0.169
Schistosoma mansoni notch 0.0392 0.1698 0.1691
Loa Loa (eye worm) hypothetical protein 0.0392 0.1697 0.1697
Brugia malayi steroid hormone receptor 0.0029 0.0046 0.0046
Loa Loa (eye worm) voltage-dependent calcium channel 0.0042 0.0104 0.0104
Plasmodium vivax hypothetical protein, conserved 0.0042 0.0108 0.2534
Echinococcus multilocularis carbonic anhydrase 0.0545 0.2389 0.2383
Schistosoma mansoni serine/threonine protein kinase 0.0247 0.1035 0.1028
Schistosoma mansoni notch 0.0392 0.1697 0.169
Schistosoma mansoni sodium-dependent amino acid transporter 0.0042 0.0108 0.01
Loa Loa (eye worm) hypothetical protein 0.2221 1 1
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0029 0.0046 0.0046
Schistosoma mansoni hypothetical protein 0.0392 0.1697 0.169
Loa Loa (eye worm) hypothetical protein 0.2221 1 1
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0545 0.2389 0.2389
Loa Loa (eye worm) hypothetical protein 0.0392 0.1697 0.1697
Trypanosoma cruzi Sulfate transporter N-terminal domain with GLY motif/Sulfate transporter family, putative 0.0034 0.0068 0.0055
Loa Loa (eye worm) hypothetical protein 0.0249 0.1048 0.1048
Schistosoma mansoni coup transcription factor 0.0029 0.0046 0.0038
Echinococcus granulosus protein jagged 2 0.0392 0.1697 0.169
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.1127 0.5033 0.5033
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0029 0.0046 0.0038
Schistosoma mansoni thyroid hormone receptor 0.0159 0.0636 0.0628
Mycobacterium tuberculosis Beta-carbonic anhydrase 0.1003 0.4472 1
Brugia malayi photoreceptor-specific nuclear receptor 0.0029 0.0046 0.0046
Brugia malayi Steroid receptor seven-up type 2 0.0029 0.0046 0.0046
Schistosoma mansoni lipoxygenase 0.0085 0.0302 0.0294
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0029 0.0046 0.0038
Onchocerca volvulus 0.0392 0.1697 0.169
Echinococcus granulosus FTZ F1 alpha 0.0029 0.0046 0.0038
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0029 0.0046 0.0046
Mycobacterium leprae Probable transmembrane transport protein 0.0243 0.1021 0.1751
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0029 0.0046 0.0046
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0029 0.0046 0.0038
Echinococcus multilocularis protein jagged 2 0.0392 0.1697 0.169
Brugia malayi hypothetical protein 0.0042 0.0108 0.0108
Echinococcus granulosus neurogenic locus notch protein 0.0392 0.1697 0.169
Onchocerca volvulus Neurogenic locus notch protein homolog 0.0392 0.1697 0.169
Mycobacterium leprae CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) 0.1258 0.563 1
Loa Loa (eye worm) hypothetical protein 0.0392 0.1697 0.1697
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0029 0.0046 0.0038
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0042 0.0108 0.01
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0042 0.0108 0.01
Schistosoma mansoni notch 0.0392 0.1697 0.169
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0029 0.0046 0.0038
Onchocerca volvulus 0.0392 0.1697 0.169
Plasmodium falciparum transporter, putative 0.0042 0.0108 0.042
Schistosoma mansoni cytochrome c oxidase subunit II 0.0126 0.0487 0.0479
Schistosoma mansoni cytochrome-c oxidase 0.0046 0.0127 0.0119
Echinococcus granulosus serotonin transporter 0.0249 0.1048 0.1041
Trichomonas vaginalis conserved hypothetical protein 0.1461 0.655 1
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0545 0.2389 0.2389
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0249 0.1048 0.1041
Schistosoma mansoni hypothetical protein 0.0175 0.0709 0.0702
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0029 0.0046 0.0046
Brugia malayi follicle stimulating hormone receptor 0.0249 0.1045 0.1045
Loa Loa (eye worm) hypothetical protein 0.0392 0.1697 0.1697
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0042 0.0108 0.0108
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0029 0.0046 0.0038
Onchocerca volvulus 0.0392 0.1697 0.169
Schistosoma mansoni sodium/chloride dependent transporter 0.0045 0.0121 0.0113
Wolbachia endosymbiont of Brugia malayi 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase 0.0073 0.0245 0.2761
Brugia malayi EGF-like domain containing protein 0.0392 0.1697 0.1697
Brugia malayi EGF-like domain containing protein 0.0392 0.1697 0.1697
Toxoplasma gondii transporter, cation channel family protein 0.0042 0.0104 0.0156
Schistosoma mansoni hypothetical protein 0.0392 0.1697 0.169
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0042 0.0108 0.0172
Loa Loa (eye worm) hypothetical protein 0.0392 0.1697 0.1697
Onchocerca volvulus 0.0392 0.1697 0.169
Schistosoma mansoni hypothetical protein 0.0392 0.1697 0.169
Onchocerca volvulus 0.0249 0.1048 0.1041
Echinococcus granulosus fibropellin Ia 0.0392 0.1697 0.169
Onchocerca volvulus Dual oxidase homolog 0.2221 1 1
Trypanosoma brucei hypothetical protein, conserved 0.0042 0.0105 0.0128
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.0042 0.0104 0.0127
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0122 0.0468 0.046
Leishmania major hypothetical protein, conserved 0.0042 0.0105 0.0114
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0029 0.0046 0.0046
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0029 0.0046 0.0038
Echinococcus multilocularis thyroid hormone receptor alpha 0.0159 0.0636 0.0628
Brugia malayi Calcium binding EGF domain containing protein 0.0392 0.1697 0.1697
Plasmodium falciparum amino acid transporter, putative 0.0042 0.0108 0.042
Echinococcus granulosus microsomal glutathione S transferase 3 0.0115 0.044 0.0432
Loa Loa (eye worm) hypothetical protein 0.1155 0.5159 0.5159
Schistosoma mansoni hypothetical protein 0.0175 0.0709 0.0702
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0029 0.0046 0.0046
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0042 0.0108 0.01
Onchocerca volvulus 0.0392 0.1697 0.169
Schistosoma mansoni hypothetical protein 0.0392 0.1697 0.169
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0042 0.0108 0.01
Schistosoma mansoni microsomal glutathione s-transferase 0.0115 0.044 0.0432
Echinococcus multilocularis voltage dependent calcium channel 0.0042 0.0104 0.0096
Schistosoma mansoni peroxidasin 0.2221 1 1
Schistosoma mansoni hypothetical protein 0.0545 0.2389 0.2383
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0029 0.0046 0.0046
Plasmodium falciparum cytochrome c oxidase subunit 2, putative 0.0046 0.0127 0.0498
Schistosoma mansoni carbonic anhydrase-related 0.0545 0.2389 0.2383
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0029 0.0046 0.0038
Echinococcus multilocularis neurogenic locus protein delta 0.0392 0.1697 0.169
Plasmodium vivax amine transporter, putative 0.0042 0.0108 0.2534
Echinococcus granulosus nuclear factor of activated T cells 5 0.0076 0.0261 0.0253
Onchocerca volvulus Peroxidasin homolog 0.2221 1 1
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.0105 0.0128
Plasmodium vivax cytochrome c oxidase subunit 2, putative 0.0046 0.0127 0.3006
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0029 0.0046 0.0038
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0545 0.2389 0.2389
Brugia malayi hypothetical protein 0.002 0.0008 0.0008
Echinococcus multilocularis ecdysone induced protein 78C 0.0029 0.0046 0.0038
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0029 0.0046 0.0046
Brugia malayi Nuclear hormone receptor-like 1 0.0029 0.0046 0.0046
Loa Loa (eye worm) solute carrier family 6 member 4 0.0249 0.1048 0.1048
Echinococcus multilocularis protein jagged 1 0.0392 0.1697 0.169
Brugia malayi EGF-like domain containing protein 0.0392 0.1697 0.1697
Echinococcus multilocularis voltage dependent calcium channel 0.0042 0.0104 0.0096
Loa Loa (eye worm) hypothetical protein 0.0392 0.1697 0.1697
Mycobacterium ulcerans transmembrane carbonic anhydrase, SulP 0.0034 0.0068 0.0042
Brugia malayi nuclear hormone receptor 0.0029 0.0046 0.0046
Echinococcus multilocularis notch 0.0392 0.1697 0.169
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0029 0.0046 0.0038
Schistosoma mansoni carbonic anhydrase-related 0.0545 0.2389 0.2383
Wolbachia endosymbiont of Brugia malayi cytochrome c oxidase, subunit 2 0.0154 0.0613 1
Brugia malayi Cadherin domain containing protein 0.0392 0.1697 0.1697
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0392 0.1697 0.1697
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0029 0.0046 0.0046
Brugia malayi Animal haem peroxidase family protein 0.2221 1 1
Schistosoma mansoni carbonic anhydrase 0.1258 0.563 0.5626
Mycobacterium ulcerans transmembrane carbonic anhydrase, SulP 0.0034 0.0068 0.0042
Loa Loa (eye worm) hypothetical protein 0.2221 1 1
Loa Loa (eye worm) hypothetical protein 0.0042 0.0104 0.0104
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0029 0.0046 0.0046
Mycobacterium leprae PROBABLE TRANSFERASE 0.007 0.0233 0.0341
Trypanosoma brucei carbonic anhydrase-like protein 0.1127 0.5033 1
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 0.0132 0.0516 0.0851
Loa Loa (eye worm) hypothetical protein 0.0392 0.1697 0.1697
Brugia malayi Animal haem peroxidase family protein 0.2221 1 1
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0029 0.0046 0.0046
Onchocerca volvulus Putative cubilin 0.0392 0.1697 0.169
Echinococcus multilocularis carbonic anhydrase 0.0545 0.2389 0.2383
Brugia malayi EGF-like domain containing protein 0.0392 0.1697 0.1697
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0029 0.0046 0.0038
Echinococcus multilocularis mitogen activated protein kinase 14 0.0132 0.0516 0.0508
Loa Loa (eye worm) hypothetical protein 0.0392 0.1697 0.1697
Echinococcus granulosus dynactin 5 p25 0.0073 0.0245 0.0237
Leishmania major carbonic anhydrase family protein, putative 0.1258 0.563 1
Onchocerca volvulus Peroxidase homolog 0.2221 1 1
Onchocerca volvulus 0.007 0.0233 0.0225
Mycobacterium ulcerans transferase 0.007 0.0233 0.0295
Brugia malayi Calcium binding EGF domain containing protein 0.0392 0.1697 0.1697
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0042 0.0108 1
Brugia malayi Doublecortin family protein 0.002 0.0008 0.0008
Schistosoma mansoni hypothetical protein 0.0392 0.1697 0.169
Echinococcus multilocularis geminin 0.0175 0.0709 0.0702
Trichomonas vaginalis AGC family protein kinase 0.0247 0.1035 0.127
Mycobacterium ulcerans integral membrane transporter 0.0034 0.0068 0.0042
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0042 0.0108 0.01
Schistosoma mansoni sodium/chloride dependent transporter 0.0042 0.0108 0.01
Echinococcus multilocularis fat cadherin tumor suppressor 0.0392 0.1697 0.169
Loa Loa (eye worm) hypothetical protein 0.0392 0.1697 0.1697
Echinococcus granulosus neurogenic locus notch protein 0.0392 0.1697 0.169
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0042 0.0108 0.01
Echinococcus granulosus delta-like protein 1 0.0392 0.1697 0.169
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0029 0.0046 0.0046
Echinococcus multilocularis protein jagged 1 0.0392 0.1697 0.169
Loa Loa (eye worm) notch protein 0.0392 0.1697 0.1697
Schistosoma mansoni notch 0.0392 0.1697 0.169
Echinococcus granulosus neural cadherin 0.0392 0.1697 0.169
Loa Loa (eye worm) hypothetical protein 0.0029 0.0046 0.0046
Onchocerca volvulus 0.2221 1 1
Brugia malayi Protein kinase domain containing protein 0.0247 0.1035 0.1035
Loa Loa (eye worm) hypothetical protein 0.0392 0.1697 0.1697
Plasmodium vivax sulfate transporter, putative 0.0034 0.0068 0.1523
Echinococcus granulosus geminin 0.0175 0.0709 0.0702
Loa Loa (eye worm) hypothetical protein 0.0029 0.0046 0.0046
Loa Loa (eye worm) hypothetical protein 0.0249 0.1048 0.1048
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0029 0.0046 0.0046
Loa Loa (eye worm) hypothetical protein 0.0042 0.0104 0.0104
Trypanosoma brucei Sulfate transporter N-terminal domain with GLY motif/Sulfate transporter family, putative 0.0034 0.0068 0.0055
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0042 0.0104 0.0096
Echinococcus granulosus neurogenic locus notch protein 4 0.0392 0.1697 0.169
Onchocerca volvulus Putative sulfate transporter 0.0211 0.0872 0.0865
Loa Loa (eye worm) hypothetical protein 0.0029 0.0046 0.0046
Schistosoma mansoni sodium/chloride dependent transporter 0.0249 0.1048 0.1041
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0042 0.0108 0.01
Echinococcus granulosus neurogenic locus protein delta 0.0392 0.1697 0.169
Echinococcus granulosus cytochrome c oxidase subunit II 0.0154 0.0613 0.0606
Mycobacterium tuberculosis Probable conserved transmembrane protein 0.0243 0.1021 0.2097
Echinococcus granulosus sodium and chloride dependent glycine 0.0042 0.0108 0.01
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0029 0.0046 0.0046
Loa Loa (eye worm) cytochrome P450 family protein 0.0028 0.0041 0.0041
Mycobacterium tuberculosis Probable transmembrane carbonic anhydrase (carbonate dehydratase) (carbonic dehydratase) 0.0701 0.3099 0.6855
Schistosoma mansoni nuclear hormone receptor 0.0029 0.0046 0.0038
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0029 0.0046 0.0046
Echinococcus granulosus voltage dependent calcium channel 0.0042 0.0104 0.0096
Onchocerca volvulus 0.0211 0.0872 0.0865
Brugia malayi EGF-like domain containing protein 0.0392 0.1697 0.1697
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0122 0.0468 0.046
Brugia malayi notch-like transmembrane receptor 0.0392 0.1697 0.1697
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0042 0.0108 0.01
Loa Loa (eye worm) hypothetical protein 0.2221 1 1
Entamoeba histolytica acetyltransferase, putative 0.0073 0.0245 0.0254
Onchocerca volvulus 0.0046 0.0127 0.0119
Loa Loa (eye worm) hypothetical protein 0.0042 0.0108 0.0108
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0042 0.0104 0.0096
Loa Loa (eye worm) animal heme peroxidase 0.2221 1 1
Loa Loa (eye worm) hypothetical protein 0.0392 0.1697 0.1697
Loa Loa (eye worm) steroid hormone receptor 0.0029 0.0046 0.0046
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0029 0.0046 0.0038
Schistosoma mansoni carbonic anhydrase 0.0545 0.2389 0.2383
Schistosoma mansoni peroxidasin 0.2221 1 1
Loa Loa (eye worm) hypothetical protein 0.0392 0.1697 0.1697
Brugia malayi phosphoinositide-dependent protein kinase I 0.0247 0.1035 0.1035
Loa Loa (eye worm) hypothetical protein 0.2221 1 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0029 0.0046 0.0038
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.0247 0.1035 0.1035
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.0105 0.0128
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0249 0.1045 0.1045
Schistosoma mansoni septate junction protein 0.0392 0.1697 0.169
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.1127 0.5033 0.5029
Brugia malayi GCC2 and GCC3 family protein 0.0392 0.1697 0.1697
Loa Loa (eye worm) hypothetical protein 0.0042 0.0108 0.0108
Echinococcus multilocularis mitogen activated protein kinase 14 0.0132 0.0516 0.0508
Loa Loa (eye worm) hypothetical protein 0.2221 1 1
Trypanosoma brucei mitogen-activated protein kinase 3, putative 0.0132 0.0516 0.0952
Schistosoma mansoni Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] 0.0392 0.1697 0.169
Toxoplasma gondii hypothetical protein 0.0037 0.0081 0.0058
Trypanosoma cruzi Sulfate transporter N-terminal domain with GLY motif/Sulfate transporter family, putative 0.0034 0.0068 0.0055
Schistosoma mansoni carbonic anhydrase-related 0.0545 0.2389 0.2383
Echinococcus multilocularis mitogen activated protein kinase 11 0.0132 0.0516 0.0508
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0042 0.0108 0.0108
Echinococcus multilocularis slit 2 protein 0.0392 0.1697 0.169
Echinococcus multilocularis 3 phosphoinositide dependent protein kinase 1 0.0247 0.1035 0.1028
Plasmodium falciparum inorganic anion exchanger, inorganic anion antiporter 0.0034 0.0068 0.0252
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0042 0.0108 0.01
Loa Loa (eye worm) animal heme peroxidase 0.2221 1 1
Echinococcus multilocularis carbonic anhydrase 0.0545 0.2389 0.2383
Loa Loa (eye worm) hypothetical protein 0.0037 0.0081 0.0081
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0132 0.0516 0.0952
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 0.0132 0.0516 0.0516
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.013 0.0505 0.0498
Loa Loa (eye worm) hypothetical protein 0.0029 0.0046 0.0046
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0029 0.0046 0.0038
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0042 0.0108 0.01
Loa Loa (eye worm) hypothetical protein 0.0392 0.1697 0.1697
Loa Loa (eye worm) hypothetical protein 0.0392 0.1697 0.1697
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0042 0.0104 0.0096
Loa Loa (eye worm) hypothetical protein 0.2221 1 1
Onchocerca volvulus 0.0042 0.0108 0.01
Loa Loa (eye worm) hypothetical protein 0.0392 0.1697 0.1697
Loa Loa (eye worm) Notch2 0.0392 0.1697 0.1697
Schistosoma mansoni RAR-like nuclear receptor 0.0029 0.0046 0.0038
Onchocerca volvulus Protein ultraspiracle homolog 0.0029 0.0046 0.0038
Toxoplasma gondii hypothetical protein 0.0545 0.2389 1
Mycobacterium ulcerans carbonic anhydrase 0.1461 0.655 1
Loa Loa (eye worm) hypothetical protein 0.0545 0.2389 0.2389
Toxoplasma gondii hypothetical protein 0.0042 0.0108 0.0172
Loa Loa (eye worm) hypothetical protein 0.0392 0.1697 0.1697
Brugia malayi Calcium binding EGF domain containing protein 0.0392 0.1697 0.1697
Loa Loa (eye worm) hypothetical protein 0.2221 1 1
Schistosoma mansoni hypothetical protein 0.013 0.0505 0.0498
Mycobacterium ulcerans hypothetical protein 0.0042 0.0105 0.0098
Brugia malayi nuclear receptor NHR-88 0.0029 0.0046 0.0046
Loa Loa (eye worm) hypothetical protein 0.2221 1 1
Mycobacterium ulcerans epoxide hydrolase EphA 0.0169 0.0681 0.0984
Loa Loa (eye worm) blistered cuticle protein 3 0.2221 1 1
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.1127 0.5033 1
Loa Loa (eye worm) norepinephrine transporter 0.0249 0.1048 0.1048
Echinococcus granulosus mitogen activated protein kinase 14 0.0132 0.0516 0.0508
Echinococcus granulosus carbonic anhydrase 0.0545 0.2389 0.2383
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0042 0.0108 0.01
Brugia malayi Muscle positioning protein 4 0.0392 0.1697 0.1697
Onchocerca volvulus Cytochrome c oxidase subunit 2 homolog 0.0046 0.0127 0.0119
Schistosoma mansoni slit 0.0392 0.1697 0.169
Loa Loa (eye worm) hypothetical protein 0.2221 1 1
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.1127 0.5033 0.5029
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.1127 0.5033 0.5033
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0042 0.0108 0.0108
Schistosoma mansoni steroid hormone receptor ad4bp 0.0029 0.0046 0.0038
Brugia malayi ecdysteroid receptor 0.0029 0.0046 0.0046
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0042 0.0108 0.01
Loa Loa (eye worm) hypothetical protein 0.0029 0.0046 0.0046
Loa Loa (eye worm) hypothetical protein 0.2221 1 1
Loa Loa (eye worm) hypothetical protein 0.0392 0.1697 0.1697
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.0247 0.1035 0.1035
Echinococcus granulosus slit 2 protein 0.0392 0.1697 0.169
Brugia malayi hypothetical protein 0.002 0.0008 0.0008
Onchocerca volvulus Peroxidase homolog 0.2221 1 1
Brugia malayi Animal haem peroxidase family protein 0.2221 1 1
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0042 0.0104 0.0096
Echinococcus multilocularis mitogen activated protein kinase 11 0.0132 0.0516 0.0508
Brugia malayi Animal haem peroxidase family protein 0.2221 1 1
Loa Loa (eye worm) cytochrome oxidase subunit 2 0.0028 0.0042 0.0042
Echinococcus multilocularis neurogenic locus notch protein 0.0392 0.1697 0.169
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0249 0.1048 0.1048
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0132 0.0516 0.0952
Mycobacterium ulcerans transmembrane cytochrome C oxidase (subunit II) CtaC 0.0046 0.0127 0.0132
Trichomonas vaginalis AGC family protein kinase 0.0247 0.1035 0.127
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0545 0.2389 0.2389
Onchocerca volvulus 0.0029 0.0046 0.0038
Leishmania major carbonic anhydrase-like protein 0.1127 0.5033 0.8933
Loa Loa (eye worm) hypothetical protein 0.0392 0.1697 0.1697
Echinococcus multilocularis serotonin transporter 0.0249 0.1048 0.1041
Mycobacterium tuberculosis Beta-carbonic anhydrase CanB 0.0801 0.3552 0.7893
Onchocerca volvulus Neurogenic locus notch homolog 0.0392 0.1698 0.1691
Echinococcus granulosus 3-phosphoinositide-dependent protein kinase 1 0.0247 0.1035 0.1028
Mycobacterium ulcerans carbonic anhydrase 0.1258 0.563 0.8586
Loa Loa (eye worm) hypothetical protein 0.0042 0.0108 0.0108
Loa Loa (eye worm) hypothetical protein 0.002 0.0008 0.0008
Brugia malayi Peroxidasin 0.2221 1 1
Loa Loa (eye worm) hypothetical protein 0.0042 0.0108 0.0108
Toxoplasma gondii cytochrome C oxidase subunit IIb, putative 0.0046 0.0127 0.0252
Entamoeba histolytica ankyrin, putative 0.0073 0.0246 0.0255
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0042 0.0108 0.01
Echinococcus granulosus protein jagged 2 0.0392 0.1697 0.169
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0029 0.0046 0.0046
Loa Loa (eye worm) serotonin transporter b 0.0249 0.1048 0.1048
Schistosoma mansoni voltage-gated cation channel 0.0042 0.0104 0.0096
Entamoeba histolytica carbonic anhydrase, putative 0.1258 0.563 1
Loa Loa (eye worm) animal heme peroxidase 0.2221 1 1
Plasmodium vivax conserved Plasmodium protein, unknown function 0.0107 0.0402 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0029 0.0046 0.0046
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0029 0.0046 0.0038
Schistosoma mansoni notch 0.0392 0.1697 0.169
Onchocerca volvulus Cytochrome c oxidase subunit 2 homolog 0.0046 0.0127 0.0119
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0042 0.0104 0.0104
Schistosoma mansoni retinoic acid receptor RXR 0.0029 0.0046 0.0038
Onchocerca volvulus 0.0042 0.0108 0.01
Toxoplasma gondii EGF family domain-containing protein 0.0392 0.1697 0.7019
Echinococcus multilocularis neurogenic locus protein delta 0.0392 0.1697 0.169
Echinococcus granulosus notch 0.0392 0.1697 0.169
Loa Loa (eye worm) hypothetical protein 0.0392 0.1697 0.1697
Schistosoma mansoni notch 0.0392 0.1697 0.169
Loa Loa (eye worm) hypothetical protein 0.0042 0.0108 0.0108
Onchocerca volvulus Bile acid receptor homolog 0.0029 0.0046 0.0038
Brugia malayi Animal haem peroxidase family protein 0.2221 1 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0029 0.0046 0.0046
Loa Loa (eye worm) hypothetical protein 0.0037 0.0081 0.0081
Echinococcus granulosus carbonic anhydrase 0.0545 0.2389 0.2383
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0545 0.2389 0.2389
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0545 0.2389 0.2389
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0029 0.0046 0.0046
Loa Loa (eye worm) hypothetical protein 0.002 0.0008 0.0008
Wolbachia endosymbiont of Brugia malayi N-acetylglucosamine-1-phosphate uridyltransferase 0.0073 0.0245 0.2761
Brugia malayi Blistered cuticle protein 3 0.2221 1 1
Echinococcus multilocularis fibropellin Ia 0.0392 0.1697 0.169
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0029 0.0046 0.0046
Echinococcus multilocularis sodium and chloride dependent glycine 0.0042 0.0108 0.01
Loa Loa (eye worm) hypothetical protein 0.0029 0.0046 0.0046
Echinococcus granulosus protein jagged 1 0.0392 0.1697 0.169
Loa Loa (eye worm) hypothetical protein 0.0392 0.1697 0.1697
Loa Loa (eye worm) hypothetical protein 0.2221 1 1
Treponema pallidum sodium- and chloride- dependent transporter 0.0249 0.1048 0.5
Loa Loa (eye worm) hypothetical protein 0.0029 0.0046 0.0046
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0042 0.0104 0.0096
Loa Loa (eye worm) hypothetical protein 0.0392 0.1697 0.1697
Mycobacterium tuberculosis Probable serine acetyltransferase CysE (sat) 0.0073 0.0245 0.0322
Echinococcus granulosus protein jagged 1 0.0392 0.1697 0.169
Brugia malayi Delta serrate ligand family protein 0.0392 0.1697 0.1697
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0042 0.0108 0.0108
Toxoplasma gondii hypothetical protein 0.0042 0.0108 0.0172
Brugia malayi Cytochrome P450 family protein 0.0028 0.0041 0.0041
Loa Loa (eye worm) hypothetical protein 0.2221 1 1
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0042 0.0104 0.0096
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.0042 0.0104 0.0127
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0042 0.0104 0.0096
Schistosoma mansoni lipoxygenase 0.0122 0.0468 0.046
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0042 0.0108 0.01
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0029 0.0046 0.0038
Loa Loa (eye worm) hypothetical protein 0.0042 0.0108 0.0108
Schistosoma mansoni membrane associated proteins in eicosanoid and glutathione metabolism family member 0.0504 0.2203 0.2197
Echinococcus multilocularis neurogenic locus notch protein 0.0392 0.1697 0.169
Loa Loa (eye worm) cytochrome P450 family protein 0.0028 0.0041 0.0041
Loa Loa (eye worm) carbonic anhydrase 3 0.1127 0.5033 0.5033
Echinococcus granulosus peroxidasin 0.2221 1 1
Onchocerca volvulus Chorion peroxidase homolog 0.2221 1 1
Echinococcus multilocularis sodium and chloride dependent glycine 0.0042 0.0108 0.01
Echinococcus granulosus carbonic anhydrase 0.0545 0.2389 0.2383
Loa Loa (eye worm) animal heme peroxidase 0.2221 1 1
Echinococcus granulosus mitogen activated protein kinase 11 0.0132 0.0516 0.0508
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0076 0.0261 0.0253
Mycobacterium tuberculosis Probable epoxide hydrolase EphA (epoxide hydratase) (arene-oxide hydratase) 0.0169 0.0681 0.132
Echinococcus granulosus ecdysone induced protein 78C 0.0029 0.0046 0.0038
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0042 0.0108 0.0172
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0042 0.0104 0.0096
Onchocerca volvulus 0.2221 1 1
Echinococcus multilocularis neurogenic locus notch protein 4 0.0392 0.1697 0.169
Entamoeba histolytica protein kinase, putative 0.0247 0.1035 0.1684
Echinococcus multilocularis peroxidasin 0.2221 1 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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