Detailed information for compound 823585

Basic information

Technical information
  • TDR Targets ID: 823585
  • Name: N-(4-bromo-3-methylphenyl)-3-[3-(thiophen-2-y lmethyl)imidazo[5,4-b]pyridin-2-yl]propanamid e
  • MW: 455.371 | Formula: C21H19BrN4OS
  • H donors: 1 H acceptors: 3 LogP: 4.17 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Nc1ccc(c(c1)C)Br)CCc1nc2c(n1Cc1cccs1)nccc2
  • InChi: 1S/C21H19BrN4OS/c1-14-12-15(6-7-17(14)22)24-20(27)9-8-19-25-18-5-2-10-23-21(18)26(19)13-16-4-3-11-28-16/h2-7,10-12H,8-9,13H2,1H3,(H,24,27)
  • InChiKey: MJSKDMBOFSJZPL-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(4-bromo-3-methyl-phenyl)-3-[3-(2-thienylmethyl)imidazo[5,4-b]pyridin-2-yl]propanamide
  • N-(4-bromo-3-methylphenyl)-3-[3-(2-thienylmethyl)-2-imidazo[5,4-b]pyridinyl]propanamide
  • N-(4-bromo-3-methyl-phenyl)-3-[3-(2-thienylmethyl)imidazo[5,4-b]pyridin-2-yl]propionamide
  • N-(4-bromo-3-methyl-phenyl)-3-[3-(thiophen-2-ylmethyl)imidazo[5,4-b]pyridin-2-yl]propanamide
  • C614-6411
  • NCGC00111081-01

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens TAR DNA binding protein Starlite/ChEMBL No references
Homo sapiens microtubule-associated protein tau Starlite/ChEMBL No references
Homo sapiens tumor protein p53 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum ko:K04380 microtubule-associated protein tau, putative Get druggable targets OG5_133504 All targets in OG5_133504
Echinococcus multilocularis tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus multilocularis tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus granulosus tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus granulosus microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Schistosoma mansoni microtubule-associated protein tau Get druggable targets OG5_133504 All targets in OG5_133504
Brugia malayi RNA recognition motif domain containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus granulosus tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni titin 0.015 0.0053 0.0076
Loa Loa (eye worm) hypothetical protein 0.0294 0.0273 0.0267
Schistosoma mansoni titin 0.0142 0.0041 0.0059
Trypanosoma brucei histone deacetylase 1 0.0442 0.0499 0.1809
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0142 0.0041 0.0035
Onchocerca volvulus Putative titin 0.0142 0.0041 0.0035
Schistosoma mansoni histone deacetylase 1 2 3 0.0177 0.0094 0.0135
Trypanosoma cruzi sedoheptulose-1,7-bisphosphatase, putative 0.0702 0.0896 0.3282
Echinococcus multilocularis neuroglian 0.0607 0.075 0.1075
Loa Loa (eye worm) hypothetical protein 0.0142 0.0041 0.0035
Schistosoma mansoni slit 0.0142 0.0041 0.0059
Echinococcus granulosus basement membrane specific heparan sulfate 0.0152 0.0056 0.0072
Echinococcus granulosus low density lipoprotein receptor ldl 0.0152 0.0056 0.0072
Echinococcus multilocularis microtubule associated protein 2 0.0833 0.1097 0.1575
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0617 0.0766 0.1097
Schistosoma mansoni hypothetical protein 0.0142 0.0041 0.0059
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0243 0.0194 0.0272
Loa Loa (eye worm) hypothetical protein 0.0617 0.0766 0.076
Schistosoma mansoni peroxidasin 0.0152 0.0056 0.0081
Loa Loa (eye worm) hypothetical protein 0.0142 0.0041 0.0035
Echinococcus granulosus tyrosine protein kinase Blk 0.0178 0.0095 0.0129
Schistosoma mansoni titin 0.0294 0.0273 0.0393
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0294 0.0273 0.0267
Loa Loa (eye worm) hypothetical protein 0.0294 0.0273 0.0267
Schistosoma mansoni hypothetical protein 0.0142 0.0041 0.0059
Echinococcus multilocularis transfer RNA-Phe 0.015 0.0053 0.0068
Loa Loa (eye worm) TK/EPH protein kinase 0.0244 0.0196 0.019
Echinococcus multilocularis epidermal growth factor receptor 0.4655 0.6933 1
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0192 0.0118 0.0161
Schistosoma mansoni cell adhesion molecule 0.015 0.0053 0.0076
Schistosoma mansoni cell adhesion molecule 0.015 0.0053 0.0076
Trypanosoma cruzi fructose-1,6-bisphosphatase, cytosolic, putative 0.1887 0.2706 1
Brugia malayi Furin-like cysteine rich region family protein 0.4655 0.6933 0.693
Brugia malayi Immunoglobulin domain containing protein 0.0152 0.0056 0.0048
Loa Loa (eye worm) hypothetical protein 0.0142 0.0041 0.0035
Loa Loa (eye worm) hypothetical protein 0.0142 0.0041 0.0035
Echinococcus granulosus roundabout 2 0.0302 0.0284 0.0402
Echinococcus multilocularis c src tyrosine kinase 0.0135 0.0031 0.0036
Schistosoma mansoni titin 0.0142 0.0041 0.0059
Echinococcus multilocularis pro neuregulin 2, membrane bound 0.0142 0.0041 0.005
Echinococcus granulosus twitchin 0.061 0.0756 0.1083
Loa Loa (eye worm) hypothetical protein 0.0465 0.0534 0.0528
Echinococcus granulosus cyclin dependent kinase 5 activator 1 0.0508 0.0599 0.0857
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0192 0.0118 0.0161
Loa Loa (eye worm) hypothetical protein 0.0472 0.0545 0.054
Brugia malayi Wrapper/rega-1/klingon homolog protein 1 0.0142 0.0041 0.0032
Echinococcus multilocularis neuroglian 0.0302 0.0284 0.0402
Toxoplasma gondii fructose-bisphospatase II 0.1887 0.2706 1
Echinococcus multilocularis twitchin 0.0146 0.0046 0.0058
Onchocerca volvulus Peroxidasin homolog 0.0142 0.0041 0.0035
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0192 0.0118 0.0161
Loa Loa (eye worm) hypothetical protein 0.0142 0.0041 0.0035
Loa Loa (eye worm) TK/INSR protein kinase 0.1648 0.2341 0.2337
Schistosoma mansoni serine/threonine protein kinase 0.0123 0.0011 0.0016
Entamoeba histolytica protein kinase domain containing protein 0.018 0.0099 0.1841
Echinococcus granulosus histone deacetylase 6 0.0259 0.0219 0.0308
Loa Loa (eye worm) hypothetical protein 0.0243 0.0195 0.0189
Loa Loa (eye worm) TK/FER protein kinase 0.0121 0.0008 0.0002
Trichomonas vaginalis histone deacetylase, putative 0.0442 0.0499 1
Echinococcus granulosus contactin 0.0302 0.0284 0.0402
Echinococcus granulosus Down syndrome cell adhesion molecule 0.016 0.0068 0.0089
Echinococcus granulosus tyrosine protein kinase Fyn 0.0192 0.0118 0.0161
Schistosoma mansoni cell adhesion molecule 0.0302 0.0284 0.041
Schistosoma mansoni basigin related 0.0152 0.0056 0.0081
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0465 0.0534 0.077
Schistosoma mansoni tyrosine kinase 0.1648 0.2341 0.3377
Brugia malayi basement membrane proteoglycan precursor 0.0152 0.0056 0.0048
Brugia malayi Immunoglobulin I-set domain containing protein 0.0302 0.0284 0.0276
Echinococcus multilocularis cell adhesion molecule:down regulated by 0.0152 0.0056 0.0072
Brugia malayi Protein kinase domain containing protein 0.0335 0.0336 0.0328
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0305 0.029 0.0284
Schistosoma mansoni basigin related 0.0152 0.0056 0.0081
Loa Loa (eye worm) hypothetical protein 0.0508 0.0599 0.0594
Brugia malayi Animal haem peroxidase family protein 0.0142 0.0041 0.0032
Brugia malayi Immunoglobulin I-set domain containing protein 0.1265 0.1755 0.1749
Echinococcus granulosus dual specificity 0.018 0.0099 0.0134
Brugia malayi Prion-like- 0.0142 0.0041 0.0032
Loa Loa (eye worm) hypothetical protein 0.0759 0.0982 0.0977
Brugia malayi hypothetical protein 0.0243 0.0195 0.0187
Schistosoma mansoni neurotracting/lsamp/neurotrimin/obcam related cell adhesion molecule 0.0152 0.0056 0.0081
Echinococcus multilocularis tyrosine protein kinase shark 0.0121 0.0008 0.0004
Schistosoma mansoni hypothetical protein 0.0152 0.0056 0.0081
Loa Loa (eye worm) TK/ALK protein kinase 0.0335 0.0336 0.033
Schistosoma mansoni neuroglian 0.0302 0.0284 0.041
Trichomonas vaginalis histone deacetylase, putative 0.0442 0.0499 1
Schistosoma mansoni tyrosine kinase 0.2462 0.3584 0.5169
Brugia malayi fructose-1,6-bisphosphatase 0.1887 0.2706 0.27
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0243 0.0194 0.0272
Trichomonas vaginalis histone deacetylase, putative 0.0442 0.0499 1
Loa Loa (eye worm) hypothetical protein 0.0142 0.0041 0.0035
Schistosoma mansoni vesicular amine transporter 0.0465 0.0534 0.077
Brugia malayi Immunoglobulin I-set domain containing protein 0.0142 0.0041 0.0032
Echinococcus granulosus histone deacetylase 6 0.0259 0.0219 0.0308
Echinococcus multilocularis insulin growth factor binding 0.0142 0.0041 0.005
Brugia malayi Histone deacetylase family protein 0.0259 0.0219 0.0211
Brugia malayi histone deacetylase 11 0.0177 0.0094 0.0085
Loa Loa (eye worm) hypothetical protein 0.0465 0.0534 0.0528
Loa Loa (eye worm) hypothetical protein 0.0121 0.0008 0.0002
Loa Loa (eye worm) SRC-1 0.0192 0.0118 0.0112
Brugia malayi Immunoglobulin I-set domain containing protein 0.0153 0.0058 0.005
Brugia malayi Immunoglobulin I-set domain containing protein 0.016 0.0068 0.006
Schistosoma mansoni ephrin receptor 0.0213 0.0149 0.0215
Echinococcus multilocularis cyclin dependent kinase 5 activator 1 0.0508 0.0599 0.0857
Schistosoma mansoni hypothetical protein 0.0152 0.0056 0.0081
Schistosoma mansoni titin 0.0142 0.0041 0.0059
Onchocerca volvulus 0.0142 0.0041 0.0035
Schistosoma mansoni subfamily M23B non-peptidase homologue (M23 family) 0.0142 0.0041 0.0059
Leishmania major histone deacetylase, putative 0.0442 0.0499 0.1809
Schistosoma mansoni tyrosine kinase 0.0135 0.0031 0.0044
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0192 0.0118 0.0161
Echinococcus granulosus insulin growth factor binding 0.0142 0.0041 0.005
Loa Loa (eye worm) hypothetical protein 0.0176 0.0093 0.0087
Onchocerca volvulus Histone deacetylase 10 homolog 0.0177 0.0094 0.0092
Echinococcus granulosus Opioid binding protein:cell adhesion molecule 0.0142 0.0041 0.005
Loa Loa (eye worm) TK/FER protein kinase 0.0121 0.0008 0.0002
Echinococcus granulosus tyrosine protein kinase Lyn 0.0196 0.0123 0.0169
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0121 0.0008 0.0004
Schistosoma mansoni hypothetical protein 0.0152 0.0056 0.0081
Echinococcus granulosus roundabout 2 0.0302 0.0284 0.0402
Loa Loa (eye worm) hypothetical protein 0.0142 0.0041 0.0035
Echinococcus granulosus tyrosine protein kinase Src42A 0.0192 0.0118 0.0161
Plasmodium vivax histone deacetylase, putative 0.0177 0.0094 0.1686
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0302 0.0284 0.0402
Loa Loa (eye worm) hypothetical protein 0.0142 0.0041 0.0035
Schistosoma mansoni hypothetical protein 0.015 0.0053 0.0076
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.0302 0.0284 0.0402
Echinococcus multilocularis dual specificity protein kinase clk2 0.0123 0.0011 0.0008
Echinococcus multilocularis Down syndrome cell adhesion molecule 0.016 0.0068 0.0089
Brugia malayi Immunoglobulin I-set domain containing protein 0.0142 0.0041 0.0032
Brugia malayi hypothetical protein 0.0152 0.0056 0.0048
Schistosoma mansoni neurotracting/lsamp/neurotrimin/obcam related cell adhesion molecule 0.0152 0.0056 0.0081
Onchocerca volvulus 0.015 0.0053 0.0048
Echinococcus granulosus histone deacetylase 6 0.0259 0.0219 0.0308
Brugia malayi Immunoglobulin I-set domain containing protein 0.0152 0.0056 0.0048
Loa Loa (eye worm) TK protein kinase 0.0178 0.0095 0.0089
Trypanosoma cruzi histone deacetylase, putative 0.0259 0.0219 0.0771
Echinococcus granulosus tyrosine kinase 0.0178 0.0095 0.0129
Loa Loa (eye worm) hypothetical protein 0.0152 0.0056 0.005
Brugia malayi Immunoglobulin I-set domain containing protein 0.0142 0.0041 0.0032
Schistosoma mansoni hemicentin 0.015 0.0053 0.0076
Loa Loa (eye worm) TK protein kinase 0.1265 0.1755 0.1751
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0142 0.0041 0.0035
Schistosoma mansoni serine/threonine protein kinase 0.018 0.0099 0.0142
Loa Loa (eye worm) TK/FER protein kinase 0.0121 0.0008 0.0002
Echinococcus multilocularis histone deacetylase 8 0.0177 0.0094 0.0127
Echinococcus granulosus dual specificity protein kinase clk2 0.0123 0.0011 0.0008
Brugia malayi Protein kinase domain containing protein 0.0171 0.0085 0.0077
Brugia malayi Histone deacetylase family protein 0.0259 0.0219 0.0211
Onchocerca volvulus Peroxidasin homolog 0.0142 0.0041 0.0035
Loa Loa (eye worm) hypothetical protein 0.0472 0.0545 0.054
Echinococcus multilocularis ephrin type A receptor 4 A 0.024 0.019 0.0266
Loa Loa (eye worm) TK/ABL protein kinase 0.0121 0.0008 0.0002
Schistosoma mansoni tyrosine kinase 0.2462 0.3584 0.5169
Brugia malayi Immunoglobulin I-set domain containing protein 0.0294 0.0273 0.0265
Echinococcus granulosus tyrosine protein kinase Fyn 0.0192 0.0118 0.0161
Trypanosoma brucei histone deacetylase, putative 0.0259 0.0219 0.0771
Onchocerca volvulus 0.0142 0.0041 0.0035
Echinococcus granulosus pro neuregulin 2 membrane bound 0.0142 0.0041 0.005
Brugia malayi hypothetical protein 0.0472 0.0545 0.0538
Loa Loa (eye worm) hypothetical protein 0.0243 0.0195 0.0189
Echinococcus granulosus fructose 16 bisphosphatase 1 0.1887 0.2706 0.3897
Leishmania major 0.1887 0.2706 1
Echinococcus multilocularis histone deacetylase 7 0.0259 0.0219 0.0308
Echinococcus multilocularis Opioid binding protein:cell adhesion molecule 0.0142 0.0041 0.005
Schistosoma mansoni cell adhesion molecule 0.0294 0.0273 0.0393
Echinococcus multilocularis titin 0.0142 0.0041 0.005
Onchocerca volvulus 0.0142 0.0041 0.0035
Schistosoma mansoni hypothetical protein 0.0142 0.0041 0.0059
Echinococcus multilocularis tumor protein p63 0.0408 0.0447 0.0637
Loa Loa (eye worm) hypothetical protein 0.0465 0.0534 0.0528
Brugia malayi histone deacetylase 1 (HD1) 0.0442 0.0499 0.0491
Echinococcus granulosus tyrosine protein kinase Src64B 0.0192 0.0118 0.0161
Brugia malayi Leucine Rich Repeat family protein 0.0142 0.0041 0.0032
Echinococcus multilocularis 0.1417 0.1987 0.2861
Echinococcus granulosus pro neuregulin 2 membrane bound 0.0152 0.0056 0.0072
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.018 0.0099 0.0324
Schistosoma mansoni serine/threonine protein kinase 0.0146 0.0046 0.0067
Loa Loa (eye worm) CAMK protein kinase 0.0153 0.0058 0.0052
Loa Loa (eye worm) one IG domain family member 0.0142 0.0041 0.0035
Brugia malayi kettin 0.0142 0.0041 0.0032
Schistosoma mansoni titin 0.0142 0.0041 0.0059
Loa Loa (eye worm) hypothetical protein 0.0142 0.0041 0.0035
Schistosoma mansoni nephrin related 0.0152 0.0056 0.0081
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0142 0.0041 0.0035
Echinococcus multilocularis Immunoglobulin 0.0152 0.0056 0.0072
Echinococcus multilocularis hemicentin 1 0.0294 0.0273 0.0385
Plasmodium falciparum histone deacetylase, putative 0.0259 0.0219 0.4259
Entamoeba histolytica hypothetical protein 0.018 0.0099 0.1841
Echinococcus multilocularis fructose 1,6 bisphosphatase 1 0.1887 0.2706 0.3897
Echinococcus multilocularis dual specificity 0.018 0.0099 0.0134
Entamoeba histolytica protein kinase, putative 0.018 0.0099 0.1841
Echinococcus granulosus tyrosine protein kinase ABL1 0.0121 0.0008 0.0004
Echinococcus granulosus defective proboscis extension response 0.0465 0.0534 0.0762
Trichomonas vaginalis histone deacetylase, putative 0.0442 0.0499 1
Onchocerca volvulus 0.0142 0.0041 0.0035
Plasmodium falciparum histone deacetylase 1 0.0442 0.0499 1
Echinococcus multilocularis leucine rich repeat containing protein 4 0.0152 0.0056 0.0072
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.1335 0.1863 0.2681
Echinococcus granulosus tyrosine protein kinase Fyn 0.0192 0.0118 0.0161
Echinococcus granulosus leucine rich repeat containing protein 4 0.0142 0.0041 0.005
Schistosoma mansoni cell adhesion molecule 0.0302 0.0284 0.041
Loa Loa (eye worm) hypothetical protein 0.0142 0.0041 0.0035
Echinococcus multilocularis titin 0.0142 0.0041 0.005
Loa Loa (eye worm) TK/FER protein kinase 0.0121 0.0008 0.0002
Loa Loa (eye worm) animal heme peroxidase 0.0142 0.0041 0.0035
Toxoplasma gondii sedoheptulose-1,7-bisphosphatase 0.0702 0.0896 0.3282
Onchocerca volvulus 0.0142 0.0041 0.0035
Loa Loa (eye worm) histone deacetylase 7A 0.0259 0.0219 0.0213
Brugia malayi Immunoglobulin domain containing protein 0.0152 0.0056 0.0048
Echinococcus granulosus histone deacetylase 3 0.0442 0.0499 0.0712
Schistosoma mansoni tyrosine kinase 0.0394 0.0426 0.0615
Echinococcus multilocularis Immunoglobulin 0.0465 0.0534 0.0762
Leishmania major histone deacetylase, putative 0.0259 0.0219 0.0771
Echinococcus multilocularis histone deacetylase 6 0.0259 0.0219 0.0308
Loa Loa (eye worm) hypothetical protein 0.0176 0.0093 0.0087
Entamoeba histolytica protein kinase, putative 0.0157 0.0064 0.1146
Trichomonas vaginalis histone deacetylase, putative 0.0442 0.0499 1
Trypanosoma cruzi histone deacetylase 1, putative 0.0442 0.0499 0.1809
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.015 0.0053 0.0047
Echinococcus multilocularis netrin receptor unc 5 0.0152 0.0056 0.0072
Echinococcus granulosus lachesin 0.0294 0.0273 0.0385
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0142 0.0041 0.0035
Schistosoma mansoni hypothetical protein 0.0142 0.0041 0.0059
Loa Loa (eye worm) TK/FER protein kinase 0.0121 0.0008 0.0002
Loa Loa (eye worm) TK/FER protein kinase 0.0121 0.0008 0.0002
Schistosoma mansoni myosin-binding protein-related 0.015 0.0053 0.0076
Echinococcus granulosus nephrin 0.015 0.0053 0.0068
Brugia malayi Immunoglobulin I-set domain containing protein 0.0142 0.0041 0.0032
Echinococcus multilocularis low density lipoprotein receptor (ldl) 0.0152 0.0056 0.0072
Loa Loa (eye worm) LAD-2 short isoform 0.0152 0.0056 0.005
Brugia malayi Prion-like- 0.0294 0.0273 0.0265
Toxoplasma gondii histone deacetylase HDAC3 0.0442 0.0499 0.1809
Trypanosoma brucei fructose-1,6-bisphosphatase 0.1887 0.2706 1
Trypanosoma cruzi histone deacetylase, putative 0.0259 0.0219 0.0771
Brugia malayi Immunoglobulin I-set domain containing protein 0.015 0.0053 0.0044
Echinococcus granulosus roundabout 2 0.0766 0.0994 0.1427
Echinococcus multilocularis histone deacetylase 0.0259 0.0219 0.0308
Brugia malayi Immunoglobulin I-set domain containing protein 0.0302 0.0284 0.0276
Echinococcus granulosus histone deacetylase 0.0259 0.0219 0.0308
Echinococcus granulosus titin 0.0142 0.0041 0.005
Echinococcus granulosus down syndrome cell adhesion 0.0142 0.0041 0.005
Echinococcus granulosus ephrin type A receptor 4 A 0.024 0.019 0.0266
Echinococcus granulosus epidermal growth factor receptor 0.4655 0.6933 1
Onchocerca volvulus 0.0153 0.0058 0.0054
Loa Loa (eye worm) CMGC/CLK protein kinase 0.0123 0.0011 0.0006
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.1123 0.1539 0.2213
Echinococcus multilocularis insulin receptor 0.1648 0.2341 0.3371
Schistosoma mansoni tyrosine kinase 0.0135 0.0031 0.0044
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.015 0.0053 0.0068
Loa Loa (eye worm) TK/FER protein kinase 0.0121 0.0008 0.0002
Brugia malayi Immunoglobulin I-set domain containing protein 0.0294 0.0273 0.0265
Schistosoma mansoni hypothetical protein 0.0152 0.0056 0.0081
Schistosoma mansoni tyrosine kinase 0.0121 0.0008 0.0012
Loa Loa (eye worm) TK/KIN16 protein kinase 0.6664 1 1
Schistosoma mansoni hypothetical protein 0.0152 0.0056 0.0081
Schistosoma mansoni histone deacetylase hda2 0.0177 0.0094 0.0135
Brugia malayi Fibronectin type III domain containing protein 0.0472 0.0545 0.0538
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0192 0.0118 0.0161
Brugia malayi Histone deacetylase 1 0.0442 0.0499 0.0491
Echinococcus multilocularis leucine rich repeats and immunoglobulin 0.0142 0.0041 0.005
Schistosoma mansoni nephrin related 0.0142 0.0041 0.0059
Echinococcus multilocularis tyrosine protein kinase HCK 0.0157 0.0064 0.0085
Brugia malayi basement membrane proteoglycan 0.0152 0.0056 0.0048
Echinococcus granulosus neuroglian 0.0607 0.075 0.1075
Schistosoma mansoni tyrosine kinase 0.0192 0.0118 0.017
Loa Loa (eye worm) TK/EGFR protein kinase 0.4655 0.6933 0.6931
Schistosoma mansoni tyrosine kinase 0.1648 0.2341 0.3377
Echinococcus multilocularis histone deacetylase 6 0.0259 0.0219 0.0308
Echinococcus granulosus insulin receptor 0.1648 0.2341 0.3371
Echinococcus granulosus fibroblast growth factor receptor 4 0.1123 0.1539 0.2213
Loa Loa (eye worm) hypothetical protein 0.0142 0.0041 0.0035
Brugia malayi Immunoglobulin I-set domain containing protein 0.0142 0.0041 0.0032
Schistosoma mansoni roundabout 0.0294 0.0273 0.0393
Brugia malayi Immunoglobulin I-set domain containing protein 0.0142 0.0041 0.0032
Loa Loa (eye worm) hypothetical protein 0.0152 0.0056 0.005
Loa Loa (eye worm) TK/FER protein kinase 0.0121 0.0008 0.0002
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.018 0.0099 0.0324
Brugia malayi Immunoglobulin I-set domain containing protein 0.0294 0.0273 0.0265
Giardia lamblia Histone deacetylase 0.0442 0.0499 1
Echinococcus granulosus epidermal growth factor receptor 0.2563 0.3737 0.5387
Echinococcus granulosus microtubule associated protein 2 0.0833 0.1097 0.1575
Loa Loa (eye worm) hypothetical protein 0.015 0.0053 0.0047
Loa Loa (eye worm) hypothetical protein 0.0294 0.0273 0.0267
Echinococcus granulosus titin 0.0142 0.0041 0.005
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.018 0.0099 0.0324
Schistosoma mansoni septate junction protein 0.0152 0.0056 0.0081
Echinococcus multilocularis tyrosine protein kinase Blk 0.0178 0.0095 0.0129
Brugia malayi Immunoglobulin I-set domain containing protein 0.0472 0.0545 0.0538
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0192 0.0118 0.0161
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0302 0.0284 0.0402
Schistosoma mansoni histone deacetylase 0.0442 0.0499 0.0719
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0302 0.0284 0.0279
Schistosoma mansoni tyrosine kinase 0.1123 0.1539 0.2219
Echinococcus granulosus tyrosine protein kinase HCK 0.0157 0.0064 0.0085
Schistosoma mansoni low-density lipoprotein receptor (ldl) 0.0152 0.0056 0.0081
Echinococcus multilocularis fibroblast growth factor receptor 4 0.1123 0.1539 0.2213
Echinococcus granulosus netrin receptor unc 5 0.0152 0.0056 0.0072
Echinococcus granulosus tyrosine protein kinase Srms 0.0121 0.0008 0.0004
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0135 0.0031 0.0036
Loa Loa (eye worm) hypothetical protein 0.0142 0.0041 0.0035
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0121 0.0008 0.0004
Echinococcus granulosus histone deacetylase 1 0.0442 0.0499 0.0712
Schistosoma mansoni serine/threonine protein kinase 0.0123 0.0011 0.0016
Brugia malayi Immunoglobulin I-set domain containing protein 0.015 0.0053 0.0044
Trypanosoma brucei sedoheptulose-1,7-bisphosphatase 0.0702 0.0896 0.3282
Loa Loa (eye worm) TK/ROR protein kinase 0.0243 0.0194 0.0189
Plasmodium falciparum histone deacetylase 2 0.0259 0.0219 0.4259
Brugia malayi Immunoglobulin I-set domain containing protein 0.0152 0.0056 0.0048
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.015 0.0053 0.0047
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0302 0.0284 0.0402
Loa Loa (eye worm) TK protein kinase 0.0157 0.0064 0.0059
Schistosoma mansoni cell adhesion molecule 0.0142 0.0041 0.0059
Loa Loa (eye worm) immunoglobulin domain-containing protein 0.0152 0.0056 0.005
Brugia malayi Immunoglobulin I-set domain containing protein 0.0142 0.0041 0.0032
Loa Loa (eye worm) hypothetical protein 0.0442 0.0499 0.0493
Echinococcus multilocularis tyrosine protein kinase otk 0.0294 0.0273 0.0385
Schistosoma mansoni titin 0.0142 0.0041 0.0059
Onchocerca volvulus 0.015 0.0053 0.0048
Loa Loa (eye worm) hypothetical protein 0.0759 0.0982 0.0977
Echinococcus multilocularis titin 0.0153 0.0058 0.0076
Trichomonas vaginalis histone deacetylase, putative 0.0442 0.0499 1
Brugia malayi Immunoglobulin I-set domain containing protein 0.0142 0.0041 0.0032
Loa Loa (eye worm) histone deacetylase 1 0.0442 0.0499 0.0493
Loa Loa (eye worm) hypothetical protein 0.0142 0.0041 0.0035
Echinococcus granulosus titin 0.0153 0.0058 0.0076
Trypanosoma cruzi histone deacetylase, putative 0.0177 0.0094 0.0305
Loa Loa (eye worm) hypothetical protein 0.0142 0.0041 0.0035
Echinococcus multilocularis pro neuregulin 2, membrane bound 0.0152 0.0056 0.0072
Schistosoma mansoni histone deacetylase 4 5 0.0259 0.0219 0.0316
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0192 0.0118 0.0161
Toxoplasma gondii fructose-bisphospatase I 0.0702 0.0896 0.3282
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0192 0.0118 0.0161
Trypanosoma cruzi histone deacetylase, putative 0.0177 0.0094 0.0305
Loa Loa (eye worm) histone deacetylase 11 0.0177 0.0094 0.0088
Brugia malayi Heparan sulfate 0.0152 0.0056 0.0048
Echinococcus multilocularis neurotracting:lsamp:neurotrimin:obcam 0.0294 0.0273 0.0385
Echinococcus granulosus 3'partial|cell adhesion molecule:down regulated by 0.0152 0.0056 0.0072
Echinococcus granulosus hemicentin 1 0.0294 0.0273 0.0385
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.1656 0.2353 0.3388
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0121 0.0008 0.0004
Schistosoma mansoni neurotracting/lsamp/neurotrimin/obcam related cell adhesion molecule 0.0294 0.0273 0.0393
Loa Loa (eye worm) hypothetical protein 0.0177 0.0094 0.0088
Toxoplasma gondii histone deacetylase HDAC5 0.0177 0.0094 0.0305
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0294 0.0273 0.0267
Brugia malayi Immunoglobulin I-set domain containing protein 0.0142 0.0041 0.0032
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0135 0.0031 0.0036
Echinococcus multilocularis tyrosine protein kinase Srms 0.0178 0.0095 0.0129
Loa Loa (eye worm) hypothetical protein 0.0142 0.0041 0.0035
Echinococcus multilocularis Immunoglobulin subtype 0.0152 0.0056 0.0072
Brugia malayi histone deacetylase 3 (HD3) 0.0442 0.0499 0.0491
Brugia malayi Immunoglobulin I-set domain containing protein 0.015 0.0053 0.0044
Schistosoma mansoni septate junction protein 0.0152 0.0056 0.0081
Trypanosoma brucei histone deacetylase 2 0.0177 0.0094 0.0305
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.018 0.0099 0.0093
Brugia malayi Immunoglobulin I-set domain containing protein 0.015 0.0053 0.0044
Echinococcus multilocularis roundabout 2 0.0766 0.0994 0.1427
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0153 0.0058 0.0052
Loa Loa (eye worm) fructose-1,6-bisphosphatase 0.1887 0.2706 0.2701
Loa Loa (eye worm) histone deacetylase 3 0.0442 0.0499 0.0493
Echinococcus granulosus titin 0.0142 0.0041 0.005
Echinococcus granulosus tyrosine kinase 0.0121 0.0008 0.0004
Echinococcus multilocularis lachesin 0.0294 0.0273 0.0385
Echinococcus granulosus Immunoglobulin 0.0152 0.0056 0.0072
Echinococcus granulosus leucine rich repeats and immunoglobulin 0.0142 0.0041 0.005
Echinococcus multilocularis Immunoglobulin 0.0152 0.0056 0.0072
Brugia malayi Protein kinase domain containing protein 0.018 0.0099 0.009
Schistosoma mansoni cell adhesion molecule 0.0152 0.0056 0.0081
Schistosoma mansoni hypothetical protein 0.0152 0.0056 0.0081
Schistosoma mansoni septate junction protein 0.0294 0.0273 0.0393
Brugia malayi ephrin receptor 1 precursor 0.0153 0.0058 0.005
Echinococcus multilocularis titin 0.0142 0.0041 0.005
Trypanosoma cruzi sedoheptulose-1,7-bisphosphatase, putative 0.0702 0.0896 0.3282
Loa Loa (eye worm) hypothetical protein 0.0152 0.0056 0.005
Loa Loa (eye worm) hypothetical protein 0.0207 0.0139 0.0134
Plasmodium vivax histone deacetylase 1, putative 0.0442 0.0499 1
Echinococcus multilocularis tyrosine protein kinase Abl 0.0135 0.0031 0.0036
Schistosoma mansoni cell adhesion molecule 0.0152 0.0056 0.0081
Brugia malayi protein-tyrosine kinase 0.0178 0.0095 0.0087
Schistosoma mansoni low-density lipoprotein receptor (ldl) 0.0152 0.0056 0.0081
Brugia malayi Myb-like DNA-binding domain containing protein 0.0142 0.0041 0.0032
Echinococcus multilocularis roundabout 2 0.0302 0.0284 0.0402
Echinococcus granulosus histone deacetylase 8 0.0177 0.0094 0.0127
Entamoeba histolytica protein kinase, putative 0.018 0.0099 0.1841
Echinococcus granulosus neuroglian 0.0302 0.0284 0.0402
Schistosoma mansoni tyrosine kinase 0.4655 0.6933 1
Onchocerca volvulus Tyrosine kinase homolog 0.6189 0.9275 1
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0465 0.0534 0.077
Brugia malayi Immunoglobulin I-set domain containing protein 0.0142 0.0041 0.0032
Entamoeba histolytica histone deacetylase, putative 0.0442 0.0499 1
Schistosoma mansoni tyrosine kinase 0.2563 0.3737 0.5391
Loa Loa (eye worm) hypothetical protein 0.0294 0.0273 0.0267
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.2563 0.3737 0.5387
Brugia malayi Immunoglobulin I-set domain containing protein 0.0142 0.0041 0.0032
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0442 0.0499 1
Toxoplasma gondii histone deacetylase HDAC2 0.0442 0.0499 0.1809
Onchocerca volvulus 0.0142 0.0041 0.0035
Brugia malayi Immunoglobulin I-set domain containing protein 0.0294 0.0273 0.0265
Brugia malayi Peroxidasin 0.0294 0.0273 0.0265
Echinococcus granulosus c src tyrosine kinase 0.0135 0.0031 0.0036
Schistosoma mansoni tyrosine kinase 0.0121 0.0008 0.0012
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0178 0.0095 0.0129
Trypanosoma brucei histone deacetylase 3 0.0259 0.0219 0.0771
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0442 0.0499 1
Schistosoma mansoni serine/threonine protein kinase 0.0153 0.0058 0.0084
Echinococcus multilocularis hemicentin 1 0.0294 0.0273 0.0385
Echinococcus multilocularis Immunoglobulin 0.0465 0.0534 0.0762
Loa Loa (eye worm) TK/FER protein kinase 0.0121 0.0008 0.0002
Trypanosoma brucei histone deacetylase 4 0.0259 0.0219 0.0771
Schistosoma mansoni histone deacetylase 4 5 0.0259 0.0219 0.0316
Brugia malayi Disorganized muscle protein 1 0.0142 0.0041 0.0032
Loa Loa (eye worm) hypothetical protein 0.0294 0.0273 0.0267
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.018 0.0099 0.0324
Trypanosoma cruzi fructose-1,6-bisphosphatase, cytosolic, putative 0.1887 0.2706 1
Plasmodium vivax histone deacetylase 2, putative 0.0259 0.0219 0.4259
Echinococcus granulosus tyrosine protein kinase shark 0.0121 0.0008 0.0004
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0192 0.0118 0.0161
Schistosoma mansoni nephrin 0.0614 0.0762 0.1099
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0192 0.0118 0.0161
Brugia malayi Immunoglobulin I-set domain containing protein 0.0294 0.0273 0.0265
Onchocerca volvulus Netrin receptor homolog 0.0142 0.0041 0.0035
Schistosoma mansoni netrin receptor unc5 0.0152 0.0056 0.0081
Schistosoma mansoni histone deacetylase 0.0442 0.0499 0.0719
Echinococcus multilocularis contactin neuroglian septate junction protein 0.0302 0.0284 0.0402
Brugia malayi Immunoglobulin I-set domain containing protein 0.0302 0.0284 0.0276
Toxoplasma gondii histone deacetylase HDAC4 0.0177 0.0094 0.0305
Echinococcus granulosus histone deacetylase 7 0.0259 0.0219 0.0308
Echinococcus multilocularis roundabout 2 0.0302 0.0284 0.0402
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0302 0.0284 0.041
Leishmania major histone deacetylase, putative 0.0442 0.0499 0.1809
Echinococcus granulosus insulin growth factor 1 receptor beta 0.1656 0.2353 0.3388
Brugia malayi Protein kinase domain containing protein 0.0123 0.0011 0.0003
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0142 0.0041 0.0035
Echinococcus granulosus Immunoglobulin subtype 0.0152 0.0056 0.0072
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0442 0.0499 1
Loa Loa (eye worm) TK/FER protein kinase 0.0121 0.0008 0.0002
Loa Loa (eye worm) histone deacetylase 0.0259 0.0219 0.0213
Loa Loa (eye worm) hypothetical protein 0.0142 0.0041 0.0035
Toxoplasma gondii histone deacetylase HDAC1 0.0259 0.0219 0.0771
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.016 0.0068 0.0062
Brugia malayi protein unc-22 0.0153 0.0058 0.005
Brugia malayi SRC-1 0.0192 0.0118 0.0109
Loa Loa (eye worm) hypothetical protein 0.0294 0.0273 0.0267
Echinococcus multilocularis down syndrome cell adhesion 0.0142 0.0041 0.005
Brugia malayi Immunoglobulin I-set domain containing protein 0.0142 0.0041 0.0032
Schistosoma mansoni titin 0.0153 0.0058 0.0084
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0178 0.0095 0.0129
Loa Loa (eye worm) hypothetical protein 0.0152 0.0056 0.005
Echinococcus multilocularis histone deacetylase 1 0.0442 0.0499 0.0712
Schistosoma mansoni cyclin-dependent kinase 5 activator 0.0508 0.0599 0.0865
Schistosoma mansoni cell adhesion molecule 0.0624 0.0777 0.1121
Echinococcus granulosus tumor protein p63 0.0408 0.0447 0.0637
Brugia malayi Immunoglobulin I-set domain containing protein 0.0152 0.0056 0.0048
Brugia malayi Tyrosine-protein kinase abl-1 0.0135 0.0031 0.0022
Schistosoma mansoni hypothetical protein 0.0142 0.0041 0.0059
Echinococcus multilocularis 0.0142 0.0041 0.005
Onchocerca volvulus 0.0142 0.0041 0.0035
Loa Loa (eye worm) hypothetical protein 0.0302 0.0284 0.0279
Schistosoma mansoni netrin receptor unc5 0.0152 0.0056 0.0081
Echinococcus multilocularis histone deacetylase 6 0.0259 0.0219 0.0308
Echinococcus granulosus peroxidasin 0.0294 0.0273 0.0385
Leishmania major histone deacetylase, putative 0.0259 0.0219 0.0771
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0465 0.0534 0.0762
Onchocerca volvulus 0.5946 0.8905 0.96
Loa Loa (eye worm) projectin 0.015 0.0053 0.0047
Plasmodium vivax histone deacetylase, putative 0.0259 0.0219 0.4259
Brugia malayi Immunoglobulin I-set domain containing protein 0.015 0.0053 0.0044
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0192 0.0118 0.0161
Schistosoma mansoni nephrin 0.0302 0.0284 0.041
Echinococcus multilocularis tyrosine kinase 0.0121 0.0008 0.0004
Brugia malayi Immunoglobulin I-set domain containing protein 0.015 0.0053 0.0044
Loa Loa (eye worm) hypothetical protein 0.0152 0.0056 0.005
Schistosoma mansoni basigin related 0.0152 0.0056 0.0081
Loa Loa (eye worm) hypothetical protein 0.0472 0.0545 0.054
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0152 0.0056 0.0072
Brugia malayi Prion-like- 0.0142 0.0041 0.0032
Echinococcus granulosus tyrosine protein kinase otk 0.0294 0.0273 0.0385
Echinococcus granulosus Immunoglobulin 0.0465 0.0534 0.0762
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.1123 0.1539 0.2213
Onchocerca volvulus 0.0142 0.0041 0.0035
Brugia malayi Protein kinase domain containing protein 0.1648 0.2341 0.2335
Schistosoma mansoni hypothetical protein 0.0142 0.0041 0.0059
Echinococcus multilocularis peroxidasin 0.0294 0.0273 0.0385
Schistosoma mansoni tyrosine kinase 0.0192 0.0118 0.017
Brugia malayi Immunoglobulin I-set domain containing protein 0.0294 0.0273 0.0265
Brugia malayi Immunoglobulin I-set domain containing protein 0.0152 0.0056 0.0048
Onchocerca volvulus Basement membrane proteoglycan homolog 0.0294 0.0273 0.0285
Schistosoma mansoni fructose-16-bisphosphatase-related 0.1887 0.2706 0.3903
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0135 0.0031 0.0044
Echinococcus granulosus Immunoglobulin 0.0152 0.0056 0.0072
Schistosoma mansoni tyrosine kinase 0.2462 0.3584 0.5169
Loa Loa (eye worm) hypothetical protein 0.0294 0.0273 0.0267
Brugia malayi Prion-like- 0.0142 0.0041 0.0032
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.015 0.0053 0.0047
Trypanosoma cruzi histone deacetylase 1, putative 0.0442 0.0499 0.1809
Loa Loa (eye worm) hypothetical protein 0.015 0.0053 0.0047
Schistosoma mansoni microtubule-associated protein tau 0.0833 0.1097 0.1582
Schistosoma mansoni low-density lipoprotein receptor (ldl) 0.0152 0.0056 0.0081
Loa Loa (eye worm) disorganized muscle protein 1 0.0142 0.0041 0.0035
Echinococcus multilocularis histone deacetylase 3 0.0442 0.0499 0.0712
Echinococcus granulosus titin 0.0153 0.0058 0.0076
Trypanosoma cruzi histone deacetylase, putative 0.0259 0.0219 0.0771
Brugia malayi Immunoglobulin domain containing protein 0.0152 0.0056 0.0048
Schistosoma mansoni tyrosine kinase 0.2563 0.3737 0.5391
Schistosoma mansoni septate junction protein 0.0294 0.0273 0.0393
Schistosoma mansoni histone deacetylase hda2 0.0259 0.0219 0.0316
Echinococcus multilocularis epidermal growth factor receptor 0.2563 0.3737 0.5387

Activities

Activity type Activity value Assay description Source Reference
Potency (binding) = 4.4668 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) = 5.6234 um PUBCHEM_BIOASSAY: qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53 Null Cells at the Permissive Temperature. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 6.3096 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 7.9433 um PUBCHEM_BIOASSAY: Counterscreen qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. This assay monitors tau fibrillation by fluorescence polarization (FP) of Alexa 594-labeled K18 P301L, which does not fibrillize readily but incorporates into growing filaments of unlabeled tau. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 12.5893 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 15.8489 um PUBCHEM_BIOASSAY: qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53ts Cells at the Nonpermissive Temperature. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Vif-A3F Interactions: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) 39.8107 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 112.2018 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) 125.8925 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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