Detailed information for compound 82945

Basic information

Technical information
  • TDR Targets ID: 82945
  • Name: [(cyclopentylamino)-phosphonomethyl]phosphoni c acid
  • MW: 259.134 | Formula: C6H15NO6P2
  • H donors: 5 H acceptors: 6 LogP: -4.61 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: OP(=O)(C(P(=O)(O)O)NC1CCCC1)O
  • InChi: 1S/C6H15NO6P2/c8-14(9,10)6(15(11,12)13)7-5-3-1-2-4-5/h5-7H,1-4H2,(H2,8,9,10)(H2,11,12,13)
  • InChiKey: LYSZBLYYIMZCOO-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • [(cyclopentylamino)-phosphono-methyl]phosphonic acid
  • 71066-40-5
  • Cyclopentylaminomethylene-1,1-bisphosphonate
  • NSC723987

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Leishmania donovani farnesyl pyrophosphate synthase Starlite/ChEMBL References
Homo sapiens farnesyl diphosphate synthase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) polyprenyl synthetase Get druggable targets OG5_127590 All targets in OG5_127590
Trichomonas vaginalis geranylgeranyl pyrophosphate synthase, putative Get druggable targets OG5_127590 All targets in OG5_127590
Mycobacterium ulcerans geranylgeranyl pyrophosphate synthase Get druggable targets OG5_127590 All targets in OG5_127590
Echinococcus granulosus farnesyl pyrophosphate synthase Get druggable targets OG5_127590 All targets in OG5_127590
Cryptosporidium parvum putative farnesyl pyrophosphate synthase Get druggable targets OG5_127590 All targets in OG5_127590
Neospora caninum hypothetical protein Get druggable targets OG5_127590 All targets in OG5_127590
Mycobacterium ulcerans geranylgeranyl pyrophosphate synthase Get druggable targets OG5_127590 All targets in OG5_127590
Leishmania donovani farnesyl pyrophosphate synthase Get druggable targets OG5_127590 All targets in OG5_127590
Leishmania major farnesyl pyrophosphate synthase Get druggable targets OG5_127590 All targets in OG5_127590
Candida albicans similar to S. cerevisiae ERG20 (YJL167W) farnesyl diphosphate synthetase (FPP synthetase) Get druggable targets OG5_127590 All targets in OG5_127590
Echinococcus multilocularis farnesyl pyrophosphate synthase Get druggable targets OG5_127590 All targets in OG5_127590
Schistosoma japonicum ko:K00787 dimethylallyltranstransferase [EC2.5.1.1], putative Get druggable targets OG5_127590 All targets in OG5_127590
Plasmodium berghei geranylgeranyl pyrophosphate synthase, putative Get druggable targets OG5_127590 All targets in OG5_127590
Toxoplasma gondii polyprenyl synthetase superfamily protein Get druggable targets OG5_127590 All targets in OG5_127590
Schistosoma mansoni farnesyl pyrophosphate synthase Get druggable targets OG5_127590 All targets in OG5_127590
Leishmania mexicana farnesyl pyrophosphate synthase, putative Get druggable targets OG5_127590 All targets in OG5_127590
Candida albicans similar to S. cerevisiae ERG20 (YJL167W) farnesyl diphosphate synthetase (FPP synthetase) Get druggable targets OG5_127590 All targets in OG5_127590
Trypanosoma cruzi farnesyl pyrophosphate synthase Get druggable targets OG5_127590 All targets in OG5_127590
Theileria parva farnesyl pyrophosphate synthetase, putative Get druggable targets OG5_127590 All targets in OG5_127590
Brugia malayi Polyprenyl synthetase family protein Get druggable targets OG5_127590 All targets in OG5_127590
Trypanosoma brucei farnesyl pyrophosphate synthase Get druggable targets OG5_127590 All targets in OG5_127590
Trypanosoma congolense farnesyl pyrophosphate synthase Get druggable targets OG5_127590 All targets in OG5_127590
Trichomonas vaginalis geranylgeranyl diphosphate synthase, putative Get druggable targets OG5_127590 All targets in OG5_127590
Giardia lamblia Farnesyl diphosphate synthase Get druggable targets OG5_127590 All targets in OG5_127590
Plasmodium vivax geranylgeranyl pyrophosphate synthase Get druggable targets OG5_127590 All targets in OG5_127590
Trypanosoma cruzi farnesyl pyrophosphate synthase, putative Get druggable targets OG5_127590 All targets in OG5_127590
Plasmodium knowlesi geranylgeranyl pyrophosphate synthase, putative Get druggable targets OG5_127590 All targets in OG5_127590
Plasmodium yoelii farnesyl pyrophosphate synthase Get druggable targets OG5_127590 All targets in OG5_127590
Babesia bovis farnesyl pyrophosphate synthetase, putative Get druggable targets OG5_127590 All targets in OG5_127590
Cryptosporidium hominis farnesyl pyrophosphate synthase Get druggable targets OG5_127590 All targets in OG5_127590
Leishmania braziliensis farnesyl pyrophosphate synthase Get druggable targets OG5_127590 All targets in OG5_127590
Leishmania infantum farnesyl pyrophosphate synthase Get druggable targets OG5_127590 All targets in OG5_127590
Trypanosoma brucei gambiense farnesyl pyrophosphate synthase, putative Get druggable targets OG5_127590 All targets in OG5_127590
Plasmodium falciparum geranylgeranyl pyrophosphate synthase, putative Get druggable targets OG5_127590 All targets in OG5_127590
Trichomonas vaginalis geranylgeranyl pyrophosphate synthase, putative Get druggable targets OG5_127590 All targets in OG5_127590
Mycobacterium tuberculosis Probable geranylgeranyl pyrophosphate synthetase IdsA2 (ggppsase) (GGPP synthetase) (geranylgeranyl diphosphate synthase) Get druggable targets OG5_127590 All targets in OG5_127590
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica eukaryotic translation initiation factor 4E, putative 0.0034 0.0505 0.4946
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0012 0.0098 0.0134
Echinococcus granulosus sex peptide receptor 0.0026 0.0346 0.0425
Schistosoma mansoni opsin-like receptor 0.0026 0.0346 0.0465
Loa Loa (eye worm) hypothetical protein 0.0026 0.0346 0.0388
Echinococcus multilocularis telomerase reverse transcriptase subunit 0.0009 0.0042 0.0012
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0026 0.0346 0.0465
Echinococcus granulosus thioredoxin glutathione reductase 0.0014 0.0125 0.0125
Schistosoma mansoni hypothetical protein 0.0012 0.0093 0.0122
Echinococcus multilocularis rhodopsin orphan GPCR 0.0026 0.0346 0.0425
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0009 0.0042 0.0012
Echinococcus granulosus KRAB A domain containing protein 0.0009 0.0042 0.0012
Schistosoma mansoni cpg binding protein 0.0014 0.0123 0.0164
Brugia malayi Pao retrotransposon peptidase family protein 0.0009 0.0042 0.0004
Trypanosoma brucei unspecified product 0.0022 0.0274 0.0316
Brugia malayi G-protein coupled receptor 0.0026 0.0346 0.0351
Brugia malayi neuropeptide F receptor 0.0026 0.0346 0.0351
Loa Loa (eye worm) hypothetical protein 0.0026 0.0346 0.0388
Echinococcus granulosus 7TM GPCR rhodopsin 0.0026 0.0346 0.0425
Echinococcus granulosus single minded 2 0.0025 0.0331 0.0405
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0016 0.0174 0.0309
Echinococcus multilocularis eukaryotic initiation factor 4A III 0.001 0.0063 0.004
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0149 0.0146
Schistosoma mansoni biogenic amine receptor 0.0026 0.0346 0.0465
Loa Loa (eye worm) melatonin receptor type 1A 0.0026 0.0346 0.0388
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.001 0.0063 0.003
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.001 0.0063 0.003
Loa Loa (eye worm) hypothetical protein 0.0026 0.0346 0.0388
Schistosoma mansoni neuropeptide receptor 0.0026 0.0346 0.0465
Mycobacterium tuberculosis Probable geranylgeranyl pyrophosphate synthetase IdsA2 (ggppsase) (GGPP synthetase) (geranylgeranyl diphosphate synthase) 0.0248 0.4424 1
Brugia malayi CXXC zinc finger family protein 0.0013 0.011 0.0081
Giardia lamblia Ribonuclease H 0.0019 0.0224 0.0416
Loa Loa (eye worm) hypothetical protein 0.0026 0.0346 0.0388
Trypanosoma brucei solanesyl-diphosphate synthase, putative 0.0062 0.1021 0.1333
Echinococcus multilocularis neuropeptide s receptor 0.0409 0.7388 1
Schistosoma mansoni hypothetical protein 0.0192 0.34 0.4603
Leishmania major DNA polymerase kappa, putative 0.0022 0.0274 0.0548
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0023 0.0299 0.0677
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0031 0.0449 0.0936
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0026 0.0346 0.0425
Mycobacterium tuberculosis Probable multifunctional geranylgeranyl pyrophosphate synthetase IdsA1 (GGPP synthetase) (ggppsase) (geranylgeranyl diphosphate 0.0062 0.1021 0.2239
Loa Loa (eye worm) hypothetical protein 0.0026 0.0346 0.0388
Loa Loa (eye worm) hypothetical protein 0.0026 0.0346 0.0388
Mycobacterium tuberculosis Probable polyprenyl-diphosphate synthase GrcC2 (polyprenyl pyrophosphate synthetase) 0.0062 0.1021 0.2239
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0274 0.0316
Echinococcus granulosus tumor protein p63 0.0333 0.5987 0.8095
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0035 0.0514 0.1083
Echinococcus granulosus rhodopsin orphan GPCR 0.0026 0.0346 0.0425
Leishmania major eukaryotic initiation factor 4a, putative 0.001 0.0063 0.0067
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0031 0.0449 0.0936
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0026 0.0346 0.0465
Brugia malayi hypothetical protein 0.0026 0.0346 0.0351
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0046 0.0721 0.0817
Loa Loa (eye worm) hypothetical protein 0.0012 0.0093 0.01
Schistosoma mansoni hypothetical protein 0.0409 0.7383 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0274 0.0316
Onchocerca volvulus 0.0016 0.0174 0.0141
Mycobacterium tuberculosis Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog) 0.001 0.0063 0.0055
Schistosoma mansoni opsin-like receptor 0.0026 0.0346 0.0465
Trypanosoma brucei RNA helicase, putative 0.0409 0.7383 1
Echinococcus granulosus geranylgeranyl pyrophosphate synthase 0.0062 0.1021 0.1342
Loa Loa (eye worm) G-protein coupled receptor 0.0026 0.0346 0.0388
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0009 0.0042 0.0012
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0035 0.0514 0.1083
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0009 0.0042 0.0012
Brugia malayi Fli-1 protein 0.0105 0.1793 0.2009
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0026 0.0346 0.0465
Echinococcus multilocularis neuropeptide receptor 0.0026 0.0346 0.0425
Echinococcus granulosus allatostatin A receptor 0.0026 0.0346 0.0425
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0014 0.0133 0.0136
Brugia malayi intermediate filament protein 0.0053 0.0852 0.0931
Echinococcus multilocularis Alpha N acetylgalactosaminidase 0.005 0.0793 0.1032
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0009 0.0033 0.0064
Schistosoma mansoni trans-prenyltransferase 0.0062 0.1021 0.138
Schistosoma mansoni growth hormone secretagogue receptor 0.0026 0.0346 0.0465
Plasmodium falciparum LCCL domain-containing protein 0.0012 0.0093 0.0068
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0026 0.0346 0.0465
Echinococcus multilocularis GA binding protein alpha chain 0.0034 0.0505 0.0641
Trichomonas vaginalis set domain proteins, putative 0.0551 1 1
Schistosoma mansoni serine/threonine protein kinase 0.0009 0.0042 0.0054
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.007 0.1153 0.1522
Loa Loa (eye worm) hypothetical protein 0.0026 0.0346 0.0388
Echinococcus multilocularis rhodopsin orphan GPCR 0.0026 0.0346 0.0425
Schistosoma mansoni neuropeptide f receptor 76f 0.0026 0.0346 0.0465
Brugia malayi translation initiation factor 4E 0.0034 0.0505 0.0534
Loa Loa (eye worm) hypothetical protein 0.0026 0.0346 0.0388
Brugia malayi hypothetical protein 0.0009 0.0042 0.0004
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0418 0.7552 0.8609
Echinococcus multilocularis Polycystic kidney disease protein 0.0012 0.0093 0.0081
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0073 0.1219 0.2702
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0026 0.0346 0.0425
Brugia malayi Dopamine receptor protein 1 0.0026 0.0346 0.0351
Brugia malayi neuropeptide F receptor 0.0026 0.0346 0.0351
Loa Loa (eye worm) hypothetical protein 0.0026 0.0346 0.0388
Schistosoma mansoni phosphoglucomutase 0.0019 0.0224 0.0301
Echinococcus granulosus eukaryotic translation initiation factor 4E 0.0034 0.0505 0.0641
Loa Loa (eye worm) neuropeptide F receptor 0.0026 0.0346 0.0388
Loa Loa (eye worm) hypothetical protein 0.0029 0.0413 0.0466
Brugia malayi Zinc knuckle family protein 0.0009 0.0042 0.0004
Loa Loa (eye worm) hypothetical protein 0.0026 0.0346 0.0388
Leishmania major mitochondrial DNA polymerase beta 0.0155 0.2719 0.6117
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0018 0.021 0.0228
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0009 0.0033 0.0064
Schistosoma mansoni amine GPCR 0.0026 0.0346 0.0465
Echinococcus granulosus serotonin receptor 0.0026 0.0346 0.0425
Onchocerca volvulus 0.0009 0.0042 0.0009
Mycobacterium tuberculosis Probable dehydrogenase 0.0031 0.0449 0.0936
Brugia malayi hypoxia-induced factor 1 0.0104 0.1791 0.2007
Echinococcus granulosus rhodopsin orphan GPCR 0.0026 0.0346 0.0425
Echinococcus multilocularis dna polymerase eta 0.0022 0.0274 0.0327
Echinococcus multilocularis thioredoxin glutathione reductase 0.0014 0.0125 0.0125
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0026 0.0346 0.0425
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0012 0.0085 0.0106
Echinococcus granulosus decaprenyl diphosphate synthase subunit 1 0.0062 0.1021 0.1342
Echinococcus granulosus rhodopsin orphan GPCR 0.0026 0.0346 0.0425
Loa Loa (eye worm) CXXC zinc finger family protein 0.0013 0.011 0.0119
Schistosoma mansoni biogenic amine (5HT) receptor 0.0026 0.0346 0.0465
Brugia malayi Dopamine receptor 0.0026 0.0346 0.0351
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0026 0.0346 0.0465
Echinococcus multilocularis G protein coupled receptor 139 0.0026 0.0346 0.0425
Trypanosoma brucei ribonuclease H1 0.0019 0.0224 0.0248
Trypanosoma brucei ingi protein (ORF1) 0.0028 0.0395 0.048
Brugia malayi ImpB/MucB/SamB family protein 0.0022 0.0274 0.0269
Onchocerca volvulus 0.0025 0.0331 0.0299
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0274 0.0316
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0026 0.0346 0.0425
Echinococcus multilocularis transfer RNA-Lys 0.0025 0.0331 0.0405
Schistosoma mansoni DNA helicase recq1 0.0014 0.0133 0.0177
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0026 0.0346 0.0351
Brugia malayi G protein-coupled receptor 0.0026 0.0346 0.0351
Loa Loa (eye worm) translation initiation factor 4E 0.0034 0.0505 0.057
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0053 0.0855 0.1117
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0274 0.0608
Echinococcus multilocularis tumor protein p63 0.0333 0.5987 0.8095
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0274 0.0316
Loa Loa (eye worm) polyprenyl synthetase 0.0062 0.1021 0.1159
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0274 0.0316
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0174 0.0309
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0046 0.0721 0.1567
Onchocerca volvulus 0.0012 0.0093 0.0059
Echinococcus multilocularis decaprenyl diphosphate synthase subunit 1 0.0062 0.1021 0.1342
Loa Loa (eye worm) hypothetical protein 0.0009 0.0033 0.0032
Echinococcus granulosus dro:myosuppressin receptor 0.0026 0.0346 0.0425
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.003 0.0414 0.0932
Onchocerca volvulus Putative hydroxypyruvate isomerase 0.0009 0.0039 0.0006
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0026 0.0346 0.0425
Loa Loa (eye worm) hypothetical protein 0.0026 0.0346 0.0388
Loa Loa (eye worm) hypothetical protein 0.0012 0.0098 0.0106
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0026 0.0346 0.0425
Echinococcus multilocularis lamin 0.0053 0.0852 0.1113
Brugia malayi Ets-domain containing protein 0.0034 0.0505 0.0534
Schistosoma mansoni hypothetical protein 0.0009 0.0042 0.0054
Brugia malayi Pao retrotransposon peptidase family protein 0.0009 0.0042 0.0004
Onchocerca volvulus 0.0026 0.0346 0.0313
Mycobacterium tuberculosis Possible maturase 0.0009 0.0042 0.0008
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.007 0.1153 0.1559
Schistosoma mansoni neuropeptide receptor 0.0026 0.0346 0.0465
Trichomonas vaginalis DNA polymerase eta, putative 0.0022 0.0274 0.0241
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0027 0.036 0.0803
Loa Loa (eye worm) thioredoxin reductase 0.0014 0.0125 0.0137
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0274 0.0608
Echinococcus multilocularis p2X purinoceptor 4 0.002 0.0238 0.0278
Onchocerca volvulus 0.0026 0.0346 0.0313
Loa Loa (eye worm) doublecortin family protein 0.0012 0.0093 0.01
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0009 0.0042 0.0012
Echinococcus granulosus RNA directed DNA polymerase reverse transcriptase 0.0009 0.0042 0.0012
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0072 0.1191 0.1353
Toxoplasma gondii histone lysine methyltransferase SET1 0.0027 0.0369 0.0829
Echinococcus granulosus g protein coupled receptor 0.0026 0.0346 0.0425
Loa Loa (eye worm) hypothetical protein 0.0026 0.0346 0.0388
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0026 0.0346 0.0465
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0274 0.0316
Schistosoma mansoni myosin xvIII 0.0026 0.0346 0.0465
Plasmodium falciparum apurinic/apyrimidinic endonuclease Apn1, putative 0.0034 0.0506 0.1016
Loa Loa (eye worm) hypothetical protein 0.0026 0.0346 0.0388
Schistosoma mansoni tar DNA-binding protein 0.0072 0.1191 0.161
Schistosoma mansoni hypothetical protein 0.0026 0.0346 0.0465
Loa Loa (eye worm) hypothetical protein 0.0007 0.0009 0.0005
Loa Loa (eye worm) hypothetical protein 0.0009 0.0039 0.0039
Trypanosoma cruzi cytochrome P450, putative 0.0012 0.0089 0.019
Brugia malayi Pao retrotransposon peptidase family protein 0.0009 0.0042 0.0004
Echinococcus granulosus GA binding protein alpha chain 0.0034 0.0505 0.0641
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0023 0.0294 0.066
Leishmania major cytochrome p450-like protein 0.0012 0.0089 0.0127
Echinococcus multilocularis farnesyl pyrophosphate synthase 0.0248 0.4424 0.5969
Trypanosoma cruzi solanesyl-diphosphate synthase 0.0062 0.1021 0.2298
Schistosoma mansoni glutathione synthetase 0.0062 0.1021 0.138
Echinococcus granulosus lipoxygenase domain containing protein 0.0012 0.0093 0.0081
Echinococcus multilocularis g-protein coupled receptor 0.0026 0.0346 0.0425
Loa Loa (eye worm) hypothetical protein 0.0026 0.0346 0.0388
Onchocerca volvulus 0.0026 0.0346 0.0313
Onchocerca volvulus 0.0012 0.0093 0.0059
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.007 0.1153 0.1559
Schistosoma mansoni geranylgeranyl pyrophosphate synthase 0.0062 0.1021 0.138
Loa Loa (eye worm) hypothetical protein 0.0026 0.0346 0.0388
Entamoeba histolytica DEAD/DEAH box helicase, putative 0.001 0.0063 0.0615
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0274 0.0608
Schistosoma mansoni rab6-interacting 0.0012 0.0093 0.0122
Schistosoma mansoni blooms syndrome DNA helicase 0.0007 0.0005 0.0004
Brugia malayi PAS domain containing protein 0.0034 0.0492 0.0519
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0046 0.0721 0.1621
Echinococcus multilocularis ribonuclease H1 0.0019 0.0224 0.026
Echinococcus multilocularis somatostatin receptor 0.0026 0.0346 0.0425
Mycobacterium tuberculosis Probable reductase 0.0031 0.0449 0.0936
Brugia malayi hypothetical protein 0.0026 0.0346 0.0351
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0022 0.0274 0.0368
Echinococcus multilocularis flap endonuclease 1 0.003 0.0414 0.0518
Loa Loa (eye worm) hypothetical protein 0.0034 0.0506 0.0571
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0026 0.0346 0.0465
Schistosoma mansoni blooms syndrome DNA helicase 0.0027 0.0371 0.0499
Trypanosoma cruzi farnesyl pyrophosphate synthase, putative 0.0248 0.4424 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0346 0.0388
Onchocerca volvulus 0.0026 0.0346 0.0313
Loa Loa (eye worm) hypothetical protein 0.0026 0.0346 0.0388
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0155 0.2719 0.6142
Echinococcus granulosus RNA directed DNA polymerase reverse transcriptase 0.0009 0.0042 0.0012
Loa Loa (eye worm) hypothetical protein 0.007 0.1153 0.131
Echinococcus granulosus g-protein coupled receptor 0.0026 0.0346 0.0425
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0022 0.0272 0.0314
Echinococcus multilocularis Glycoside hydrolase, family 27 0.005 0.0793 0.1032
Trypanosoma brucei DNA polymerase IV, putative 0.0022 0.0274 0.0316
Loa Loa (eye worm) hypothetical protein 0.0026 0.0346 0.0388
Trypanosoma cruzi cytochrome P450, putative 0.0012 0.0089 0.019
Echinococcus multilocularis serotonin receptor 0.0026 0.0346 0.0425
Leishmania major ribonuclease H1, putative 0.0019 0.0224 0.0435
Echinococcus multilocularis musashi 0.0053 0.0852 0.1113
Mycobacterium tuberculosis Probable endonuclease IV End (endodeoxyribonuclease IV) (apurinase) 0.0034 0.0506 0.1065
Leishmania major DNA polymerase eta, putative 0.0022 0.0274 0.0548
Loa Loa (eye worm) hypothetical protein 0.0016 0.0174 0.0193
Loa Loa (eye worm) hypothetical protein 0.0012 0.0098 0.0106
Brugia malayi Pao retrotransposon peptidase family protein 0.0009 0.0042 0.0004
Loa Loa (eye worm) hypothetical protein 0.0026 0.0346 0.0388
Brugia malayi AMP-binding enzyme family protein 0.0016 0.0174 0.0155
Loa Loa (eye worm) hypothetical protein 0.0026 0.0346 0.0388
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0022 0.0274 0.0548
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0034 0.0505 0.0473
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0026 0.0346 0.0388
Loa Loa (eye worm) hypothetical protein 0.0026 0.0346 0.0388
Echinococcus granulosus 7tm_1 domain containing protein 0.0026 0.0346 0.0425
Schistosoma mansoni lamin 0.0053 0.0852 0.1151
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.005 0.0793 0.1071
Echinococcus multilocularis rhodopsin orphan GPCR 0.0026 0.0346 0.0425
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0026 0.0346 0.0425
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0022 0.0272 0.0605
Onchocerca volvulus 0.0013 0.011 0.0077
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0016 0.0174 0.0309
Brugia malayi ORL1-like opioid receptor 0.0026 0.0346 0.0351
Schistosoma mansoni loxhd1 0.0012 0.0093 0.0122
Toxoplasma gondii ribonuclease HI protein 0.0019 0.0224 0.0502
Schistosoma mansoni cellular tumor antigen P53 0.0049 0.0767 0.1036
Trypanosoma cruzi solanesyl-diphosphate synthase, putative 0.0062 0.1021 0.2298
Echinococcus multilocularis fmrfamide receptor 0.0026 0.0346 0.0425
Schistosoma mansoni phosphoglucomutase 0.0019 0.0224 0.0301
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0046 0.0721 0.0782
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0026 0.0346 0.0465
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.007 0.1153 0.2602
Loa Loa (eye worm) hypothetical protein 0.0026 0.0346 0.0388
Echinococcus granulosus dna polymerase kappa 0.0022 0.0274 0.0327
Giardia lamblia DINP protein human, muc B family 0.0022 0.0274 0.0529
Mycobacterium tuberculosis Probable oxidoreductase 0.0035 0.0514 0.1083
Brugia malayi Pre-SET motif family protein 0.007 0.1153 0.1276
Treponema pallidum ATP-dependent RNA helicase 0.001 0.0063 0.0568
Entamoeba histolytica geranylgeranyl pyrophosphate synthetase, putative 0.0062 0.1021 1
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0053 0.0852 0.0966
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0022 0.0274 0.0327
Schistosoma mansoni hypothetical protein 0.0026 0.0346 0.0465
Echinococcus granulosus neuropeptide receptor 0.0026 0.0346 0.0425
Trichomonas vaginalis reverse transcriptases, putative 0.0009 0.0042 0.0009
Brugia malayi putative neuropeptide receptor 0.0026 0.0346 0.0351
Brugia malayi hypothetical protein 0.0026 0.0346 0.0351
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0022 0.0274 0.0327
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.007 0.1153 0.1559
Plasmodium vivax octaprenyl pyrophosphate synthase, putative 0.0062 0.1021 0.2307
Echinococcus multilocularis rhodopsin orphan GPCR 0.0026 0.0346 0.0425
Brugia malayi Ets-domain containing protein 0.0034 0.0505 0.0534
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0026 0.0346 0.0425
Onchocerca volvulus 0.0026 0.0346 0.0313
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0009 0.0033 0.0064
Loa Loa (eye worm) flap endonuclease-1 0.003 0.0414 0.0467
Echinococcus granulosus lamin dm0 0.0053 0.0852 0.1113
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0026 0.0346 0.0465
Echinococcus multilocularis serotonin receptor 0.0026 0.0346 0.0425
Schistosoma mansoni opsin-like receptor 0.0026 0.0346 0.0465
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0026 0.0346 0.0465
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0014 0.0133 0.0136
Mycobacterium tuberculosis Conserved hypothetical protein 0.0082 0.1372 0.3039
Plasmodium falciparum octaprenyl pyrophosphate synthase 0.0062 0.1021 0.2197
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.005 0.0793 0.1071
Echinococcus multilocularis eukaryotic translation initiation factor 4E 0.0034 0.0505 0.0641
Chlamydia trachomatis geranylgeranyl pyrophosphate synthase 0.0062 0.1021 1
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0026 0.0346 0.0388
Loa Loa (eye worm) hypothetical protein 0.0012 0.0093 0.01
Trypanosoma brucei unspecified product 0.0015 0.0149 0.0146
Onchocerca volvulus 0.0053 0.0852 0.0821
Echinococcus granulosus eukaryotic initiation factor 4A 0.001 0.0063 0.004
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0016 0.0174 0.0309
Trichomonas vaginalis reverse transcriptase [C. elegans], putative 0.0009 0.0042 0.0009
Schistosoma mansoni polycystin 1-related 0.0012 0.0093 0.0122
Schistosoma mansoni eukaryotic translation initiation factor 4e 0.0034 0.0505 0.0681
Mycobacterium ulcerans DNA polymerase IV 0.0022 0.0274 0.0536
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0029 0.0397 0.0447
Brugia malayi hypothetical protein 0.0012 0.0093 0.0061
Brugia malayi larval opioid receptor 0.0026 0.0346 0.0351
Brugia malayi Pao retrotransposon peptidase family protein 0.0009 0.0042 0.0004
Loa Loa (eye worm) hypoxia-induced factor 1 0.0104 0.1791 0.2037
Echinococcus granulosus neuropeptides capa receptor 0.0026 0.0346 0.0425
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0073 0.1219 0.2748
Brugia malayi Flap endonuclease-1 0.003 0.0414 0.043
Schistosoma mansoni rab6-interacting 0.0012 0.0093 0.0122
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0022 0.0274 0.0307
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0009 0.0033 0.0032
Loa Loa (eye worm) hypothetical protein 0.0026 0.0346 0.0388
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0155 0.2719 0.6142
Brugia malayi Pao retrotransposon peptidase family protein 0.0009 0.0042 0.0004
Echinococcus granulosus neuropeptide Y receptor 0.0026 0.0346 0.0425
Toxoplasma gondii thioredoxin reductase 0.0014 0.0125 0.0278
Schistosoma mansoni alpha-1 adrenergic receptor 0.0026 0.0346 0.0465
Schistosoma mansoni mixed-lineage leukemia protein mll 0.003 0.0423 0.057
Onchocerca volvulus 0.0026 0.0346 0.0313
Brugia malayi Serotonin receptor 0.0026 0.0346 0.0351
Brugia malayi follicle stimulating hormone receptor 0.0418 0.7552 0.8604
Plasmodium falciparum acyl-CoA synthetase 0.0012 0.0098 0.008
Schistosoma mansoni amine GPCR 0.0026 0.0346 0.0465
Loa Loa (eye worm) hypothetical protein 0.0026 0.0346 0.0388
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0034 0.0505 0.0473
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0149 0.0146
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0018 0.021 0.0463
Loa Loa (eye worm) intermediate filament protein 0.0053 0.0852 0.0966
Loa Loa (eye worm) hypothetical protein 0.0012 0.0098 0.0106
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.007 0.1153 0.1522
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0007 0.0005 0.0006
Brugia malayi reverse transcriptase 0.0009 0.0042 0.0004
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0026 0.0346 0.0425
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0014 0.0133 0.0108
Loa Loa (eye worm) hypothetical protein 0.0026 0.0346 0.0388
Plasmodium falciparum thioredoxin reductase 0.0014 0.0125 0.0143
Loa Loa (eye worm) hypothetical protein 0.0026 0.0346 0.0388
Schistosoma mansoni single-minded 0.0034 0.0492 0.0664
Echinococcus granulosus neuropeptide s receptor 0.0409 0.7388 1
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0046 0.0721 0.1621
Onchocerca volvulus 0.0026 0.0346 0.0313
Onchocerca volvulus 0.0026 0.0346 0.0313
Loa Loa (eye worm) cytochrome P450 family protein 0.0012 0.0089 0.0096
Echinococcus granulosus geminin 0.0192 0.34 0.4577
Mycobacterium leprae PROBABLE POLYPRENYL-DIPHOSPHATE SYNTHASE GRCC1 (POLYPRENYL PYROPHOSPHATE SYNTHETASE) 0.0062 0.1021 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0346 0.0388
Treponema pallidum octaprenyl-diphosphate synthase 0.0062 0.1021 1
Brugia malayi Polyprenyl synthetase family protein 0.0248 0.4424 0.5021
Schistosoma mansoni amine GPCR 0.0026 0.0346 0.0465
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0026 0.0346 0.0351
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0009 0.0033 0.0064
Brugia malayi Pao retrotransposon peptidase family protein 0.0009 0.0042 0.0004
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0012 0.0098 0.0134
Schistosoma mansoni lipoxygenase 0.0032 0.0458 0.0617
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0031 0.0449 0.0936
Leishmania major 4-coumarate:coa ligase-like protein 0.0016 0.0174 0.0321
Brugia malayi GnHR receptor homolog 0.0026 0.0346 0.0351
Loa Loa (eye worm) hypothetical protein 0.0026 0.0346 0.0388
Schistosoma mansoni terminal deoxycytidyl transferase 0.0022 0.0274 0.0368
Brugia malayi Thioredoxin reductase 0.0014 0.0125 0.0099
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0274 0.0316
Plasmodium falciparum geranylgeranyl pyrophosphate synthase, putative 0.0248 0.4424 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0012 0.0089 0.0096
Trypanosoma brucei DNA polymerase IV, putative 0.0022 0.0274 0.0316
Trypanosoma brucei Eukaryotic translation initiation factor 4E-1 0.0034 0.0505 0.063
Schistosoma mansoni ets-related 0.0105 0.1793 0.2427
Plasmodium falciparum flap endonuclease 1 0.003 0.0414 0.0806
Brugia malayi Cytochrome P450 family protein 0.0012 0.0089 0.0058
Trypanosoma cruzi ribonuclease H1, putative 0.0019 0.0224 0.0497
Echinococcus granulosus rhodopsin orphan GPCR 0.0026 0.0346 0.0425
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0034 0.0505 0.0473
Giardia lamblia Flap structure-specific endonuclease 0.003 0.0414 0.0849
Onchocerca volvulus 0.0026 0.0346 0.0313
Loa Loa (eye worm) hypothetical protein 0.0026 0.0346 0.0388
Leishmania major 4-coumarate:coa ligase-like protein 0.0016 0.0174 0.0321
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0026 0.0346 0.0425
Brugia malayi Pao retrotransposon peptidase family protein 0.0009 0.0042 0.0004
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0031 0.0449 0.0936
Loa Loa (eye worm) hypothetical protein 0.0026 0.0345 0.0388
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0018 0.021 0.0402
Brugia malayi RNase H family protein 0.0019 0.0224 0.0213
Onchocerca volvulus 0.0009 0.0042 0.0009
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0026 0.0346 0.0465
Brugia malayi TAR-binding protein 0.0072 0.1191 0.1319
Schistosoma mansoni DNA polymerase eta 0.0022 0.0274 0.0368
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0026 0.0345 0.0424
Loa Loa (eye worm) hypothetical protein 0.0053 0.0852 0.0966
Echinococcus multilocularis fmrfamide receptor 0.0026 0.0346 0.0425
Onchocerca volvulus 0.0026 0.0346 0.0313
Echinococcus multilocularis dro:myosuppressin receptor 0.0026 0.0346 0.0425
Echinococcus granulosus tar DNA binding protein 0.0072 0.1191 0.1574
Brugia malayi Polyprenyl synthetase family protein 0.0062 0.1021 0.1124
Brugia malayi AMP-binding enzyme family protein 0.0016 0.0174 0.0155
Echinococcus multilocularis prenyl (decaprenyl) diphosphate synthase 0.0062 0.1021 0.1342
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0014 0.0125 0.0197
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0026 0.0346 0.0465
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.003 0.0427 0.0836
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.003 0.0414 0.0507
Mycobacterium ulcerans endonuclease IV 0.0034 0.0506 0.1065
Echinococcus granulosus intermediate filament protein 0.0053 0.0852 0.1113
Loa Loa (eye worm) neuropeptide F receptor 0.0026 0.0346 0.0388
Echinococcus multilocularis g protein coupled receptor 0.0026 0.0346 0.0425
Schistosoma mansoni flap endonuclease-1 0.0027 0.0362 0.0487
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0035 0.0514 0.4866
Brugia malayi Pao retrotransposon peptidase family protein 0.0009 0.0042 0.0004
Brugia malayi Melibiase family protein 0.0033 0.0486 0.0512
Trypanosoma brucei unspecified product 0.0028 0.0395 0.048
Brugia malayi Serotonin receptor 0.0026 0.0346 0.0351
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0014 0.0133 0.0108
Echinococcus granulosus farnesyl pyrophosphate synthase 0.0248 0.4424 0.5969
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0046 0.0721 0.0936
Loa Loa (eye worm) hypothetical protein 0.0027 0.0376 0.0423
Schistosoma mansoni protein kinase 0.0009 0.0042 0.0054
Brugia malayi Melatonin receptor type 1A 0.0026 0.0346 0.0351
Schistosoma mansoni P2X receptor subunit 0.002 0.0238 0.0319
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0026 0.0346 0.0425
Echinococcus granulosus rhodopsin orphan GPCR 0.0026 0.0346 0.0425
Mycobacterium ulcerans putative regulatory protein 0.0025 0.0331 0.0666
Echinococcus granulosus g protein coupled receptor 0.0026 0.0346 0.0425
Entamoeba histolytica acyl-CoA synthetase, putative 0.0016 0.0174 0.1706
Loa Loa (eye worm) geranylgeranyl pyrophosphate synthetase 0.0062 0.1021 0.1159
Onchocerca volvulus 0.0026 0.0346 0.0313
Brugia malayi G-protein coupled receptor 0.0026 0.0346 0.0351
Leishmania major eukaryotic translation initiation factor-like protein 0.0034 0.0505 0.1074
Loa Loa (eye worm) hypothetical protein 0.0049 0.0767 0.0869
Echinococcus multilocularis rhodopsin orphan GPCR 0.0026 0.0346 0.0425
Entamoeba histolytica geranylgeranyl pyrophosphate synthase, putative 0.0062 0.1021 1
Trichomonas vaginalis alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative 0.0033 0.0486 0.0454
Trichomonas vaginalis DNA helicase recq, putative 0.0034 0.0504 0.0472
Toxoplasma gondii endonuclease IV APN 0.0034 0.0506 0.1139
Echinococcus granulosus lipoxygenase domain containing protein 0.0012 0.0093 0.0081
Loa Loa (eye worm) hypothetical protein 0.0113 0.1952 0.2221
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0031 0.0449 0.4214
Loa Loa (eye worm) hypothetical protein 0.0012 0.0098 0.0106
Treponema pallidum ribonuclease H (rnhA) 0.0019 0.0224 0.216
Loa Loa (eye worm) hypothetical protein 0.0026 0.0346 0.0388
Leishmania major solanesyl-diphosphate synthase, putative 0.0062 0.1021 0.2249
Trichomonas vaginalis NeSL-1_NeSL reverse transcriptases, putative 0.0009 0.0042 0.0009
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0022 0.0274 0.0241
Echinococcus multilocularis allatostatin A receptor 0.0026 0.0346 0.0425
Trypanosoma cruzi trypanothione reductase, putative 0.0014 0.0125 0.0272
Leishmania major trypanothione reductase 0.0014 0.0125 0.0209
Echinococcus granulosus rhodopsin orphan GPCR 0.0026 0.0346 0.0425
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0155 0.2719 0.3646
Echinococcus granulosus peptide allatostatin:somatostatin 0.0026 0.0346 0.0425
Echinococcus multilocularis neuropeptides capa receptor 0.0026 0.0346 0.0425
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0026 0.0345 0.0424
Mycobacterium ulcerans geranylgeranyl pyrophosphate synthase 0.0248 0.4424 1
Echinococcus granulosus p2X purinoceptor 4 0.002 0.0238 0.0278
Echinococcus granulosus neuropeptide receptor A26 0.0409 0.7388 1
Echinococcus granulosus biogenic amine 5HT receptor 0.0026 0.0346 0.0425
Trypanosoma brucei trypanothione reductase 0.0014 0.0125 0.0113
Loa Loa (eye worm) hypothetical protein 0.0026 0.0346 0.0388
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0026 0.0346 0.0465
Trichomonas vaginalis reverse transcriptases, putative 0.0009 0.0042 0.0009
Loa Loa (eye worm) hypothetical protein 0.0026 0.0346 0.0388
Loa Loa (eye worm) hypothetical protein 0.0026 0.0346 0.0388
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0026 0.0346 0.0351
Onchocerca volvulus 0.0026 0.0346 0.0313
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0274 0.0608
Loa Loa (eye worm) hypothetical protein 0.0026 0.0346 0.0388
Trichomonas vaginalis geranylgeranyl diphosphate synthase, putative 0.0248 0.4424 0.4405
Plasmodium vivax flap endonuclease 1, putative 0.003 0.0414 0.0936
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0026 0.0346 0.0425
Echinococcus granulosus cpg binding protein 0.0014 0.0123 0.0122
Mycobacterium leprae conserved hypothetical protein 0.0009 0.0039 0.0056
Brugia malayi Dopamine receptor protein 2 0.0026 0.0346 0.0351
Echinococcus granulosus orexin receptor type 2 0.0026 0.0346 0.0425
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0022 0.0272 0.0605
Loa Loa (eye worm) hypothetical protein 0.0026 0.0346 0.0388
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0012 0.0089 0.0115
Onchocerca volvulus 0.0026 0.0346 0.0313
Schistosoma mansoni P2X receptor subunit 0.002 0.0238 0.0319
Brugia malayi hypothetical protein 0.0026 0.0346 0.0351
Trypanosoma cruzi polyprenyl synthase, putative 0.0062 0.1021 0.2298
Echinococcus multilocularis lamin dm0 0.0053 0.0852 0.1113
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0009 0.0042 0.0012
Trichomonas vaginalis flap endonuclease-1, putative 0.003 0.0414 0.0382
Brugia malayi Pao retrotransposon peptidase family protein 0.0009 0.0042 0.0004
Leishmania major farnesyl pyrophosphate synthase 0.0248 0.4424 1
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0026 0.0346 0.0465
Schistosoma mansoni intermediate filament proteins 0.0053 0.0852 0.1151
Schistosoma mansoni aryl hydrocarbon receptor 0.0034 0.0492 0.0664
Brugia malayi hypothetical protein 0.0026 0.0346 0.0351
Mycobacterium ulcerans hypothetical protein 0.0016 0.0174 0.0309
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0034 0.0505 0.057
Echinococcus multilocularis rhodopsin orphan GPCR 0.0026 0.0346 0.0425
Schistosoma mansoni amine GPCR 0.0026 0.0346 0.0465
Loa Loa (eye worm) hypothetical protein 0.0014 0.0133 0.0146
Onchocerca volvulus Neuropeptide F receptor homolog 0.0026 0.0346 0.0313
Plasmodium vivax thioredoxin reductase, putative 0.0014 0.0125 0.0283
Onchocerca volvulus 0.0053 0.0852 0.0821
Loa Loa (eye worm) hypothetical protein 0.0026 0.0346 0.0388
Echinococcus granulosus tachykinin peptides receptor 99D 0.0026 0.0346 0.0425
Loa Loa (eye worm) hypothetical protein 0.0016 0.0174 0.0193
Loa Loa (eye worm) RecQ helicase 0.0034 0.0504 0.0569
Onchocerca volvulus Ribonuclease H1 homolog 0.0019 0.0224 0.0192
Schistosoma mansoni tar DNA-binding protein 0.0072 0.1191 0.161
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0012 0.0085 0.0106
Schistosoma mansoni DNA helicase recq5 0.0014 0.0133 0.0177
Trypanosoma cruzi DNA polymerase eta, putative 0.0022 0.0274 0.0608
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.005 0.0793 0.1071
Toxoplasma gondii hypothetical protein 0.0025 0.0331 0.0744
Schistosoma mansoni biogenic amine receptor 0.0026 0.0346 0.0465
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0034 0.0505 0.0473
Schistosoma mansoni hypothetical protein 0.0045 0.0701 0.0946
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0009 0.0033 0.0064
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0484 0.8771 1
Echinococcus multilocularis lipoxygenase domain containing protein 0.0012 0.0093 0.0081
Echinococcus granulosus RUN 0.0012 0.0093 0.0081
Schistosoma mansoni amine GPCR 0.0026 0.0346 0.0465
Schistosoma mansoni biogenic amine (5HT) receptor 0.0026 0.0346 0.0465
Trypanosoma brucei cytochrome P450, putative 0.0012 0.0089 0.0064
Loa Loa (eye worm) hypothetical protein 0.0026 0.0346 0.0388
Toxoplasma gondii polyprenyl synthetase superfamily protein 0.0062 0.1021 0.2303
Echinococcus granulosus rhodopsin orphan GPCR 0.0026 0.0346 0.0425
Echinococcus granulosus G protein coupled receptor 139 0.0026 0.0346 0.0425
Loa Loa (eye worm) fli-1 protein 0.0105 0.1793 0.204
Brugia malayi hypothetical protein 0.0026 0.0346 0.0351
Brugia malayi RNA binding protein 0.0072 0.1191 0.1319
Plasmodium falciparum glutathione reductase 0.0014 0.0125 0.0143
Trypanosoma cruzi Eukaryotic translation initiation factor 4E-1 0.0034 0.0505 0.1131
Schistosoma mansoni hypothetical protein 0.0192 0.34 0.4603
Loa Loa (eye worm) polyprenyl synthetase 0.0248 0.4424 0.5041
Echinococcus multilocularis eukaryotic initiation factor 4A 0.001 0.0063 0.004
Plasmodium vivax apurinic/apyrimidinic endonuclease Apn1, putative 0.0034 0.0506 0.1144
Echinococcus granulosus RNA directed DNA polymerase 0.0009 0.0042 0.0012
Echinococcus multilocularis cpg binding protein 0.0014 0.0123 0.0122
Echinococcus multilocularis bloom syndrome protein 0.0034 0.0504 0.064
Echinococcus granulosus histone lysine methyltransferase setb 0.007 0.1153 0.1522
Brugia malayi Pao retrotransposon peptidase family protein 0.0009 0.0042 0.0004
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0026 0.0346 0.0465
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0026 0.0346 0.0465
Loa Loa (eye worm) hypothetical protein 0.0033 0.0486 0.0549
Onchocerca volvulus 0.007 0.1153 0.1123
Loa Loa (eye worm) hypothetical protein 0.0022 0.0274 0.0307
Loa Loa (eye worm) CYP4Cod1 0.0012 0.0089 0.0096
Trichomonas vaginalis DNA helicase recq1, putative 0.0034 0.0504 0.0472
Schistosoma mansoni tar DNA-binding protein 0.0072 0.1191 0.161
Loa Loa (eye worm) hypothetical protein 0.0026 0.0346 0.0388
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0033 0.0486 0.0655
Trypanosoma cruzi solanesyl-diphosphate synthase, putative 0.0062 0.1021 0.2298
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0009 0.0042 0.0012
Mycobacterium ulcerans acyl-CoA synthetase 0.0016 0.0174 0.0309
Brugia malayi hypothetical protein 0.0012 0.0093 0.0061
Echinococcus multilocularis RUN 0.0012 0.0093 0.0081
Echinococcus multilocularis p2X purinoceptor 4 0.002 0.0238 0.0278
Schistosoma mansoni cpg binding protein 0.0014 0.0123 0.0164
Schistosoma mansoni hypothetical protein 0.0009 0.0042 0.0054
Entamoeba histolytica acyl-CoA synthetase, putative 0.0016 0.0174 0.1706
Schistosoma mansoni histamine h1 receptor 0.0026 0.0346 0.0465
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0026 0.0346 0.0465
Echinococcus granulosus flap endonuclease 1 0.003 0.0414 0.0518
Brugia malayi DNA-(Apurinic or apyrimidinic site) lyase 0.0034 0.0506 0.0535
Loa Loa (eye worm) TAR-binding protein 0.0072 0.1191 0.1353
Brugia malayi ImpB/MucB/SamB family protein 0.0022 0.0274 0.0269
Brugia malayi hypothetical protein 0.0009 0.0042 0.0004
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0014 0.0133 0.0146
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0026 0.0346 0.0425
Echinococcus granulosus Polycystic kidney disease protein 0.0012 0.0093 0.0081
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0274 0.0316
Echinococcus granulosus hypothetical protein 0.0026 0.0346 0.0425
Loa Loa (eye worm) hypothetical protein 0.0026 0.0346 0.0388
Brugia malayi Pao retrotransposon peptidase family protein 0.0009 0.0042 0.0004
Echinococcus granulosus fmrfamide receptor 0.0026 0.0346 0.0425
Echinococcus multilocularis rhodopsin orphan GPCR 0.0026 0.0346 0.0425
Echinococcus multilocularis sex peptide receptor 0.0026 0.0346 0.0425
Leishmania major eukaryotic translation initiation factor eIF-4E, putative 0.0034 0.0505 0.1074
Onchocerca volvulus 0.0026 0.0346 0.0313
Entamoeba histolytica recQ family helicase, putative 0.0018 0.021 0.2054
Mycobacterium leprae PROBABLE ENDONUCLEASE IV END (ENDODEOXYRIBONUCLEASE IV) (APURINASE) 0.0034 0.0506 0.4788
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0014 0.0133 0.0136
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0022 0.0274 0.0536
Trypanosoma cruzi farnesyl pyrophosphate synthase 0.0248 0.4424 1
Trypanosoma cruzi polyprenyl synthase, putative 0.0062 0.1021 0.2298
Echinococcus granulosus lamin 0.0053 0.0852 0.1113
Echinococcus granulosus bloom syndrome protein 0.0034 0.0504 0.064
Schistosoma mansoni biogenic amine receptor 0.0026 0.0346 0.0465
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.007 0.1153 0.1559
Brugia malayi hypothetical protein 0.0026 0.0346 0.0351
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.003 0.0414 0.0926
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0009 0.0033 0.0064
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0026 0.0346 0.0425
Brugia malayi Bloom's syndrome protein homolog 0.0034 0.0504 0.0533
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0014 0.0133 0.0161
Loa Loa (eye worm) hypothetical protein 0.0026 0.0346 0.0388
Echinococcus granulosus neuropeptide FF receptor 2 0.0026 0.0346 0.0425
Entamoeba histolytica recQ family DNA helicase 0.0007 0.0005 0.005
Echinococcus multilocularis neuropeptide FF receptor 2 0.0026 0.0346 0.0425
Echinococcus granulosus alpha 1A adrenergic receptor 0.0026 0.0346 0.0425
Brugia malayi Zinc knuckle family protein 0.0009 0.0042 0.0004
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0016 0.0174 0.1427
Loa Loa (eye worm) hypothetical protein 0.0052 0.0834 0.0945
Echinococcus multilocularis lipoxygenase domain containing protein 0.0012 0.0093 0.0081
Loa Loa (eye worm) hypothetical protein 0.001 0.0063 0.0066
Toxoplasma gondii polyprenyl synthetase superfamily protein 0.0248 0.4424 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.0327 0.0367
Trichomonas vaginalis ribonuclease H1, putative 0.0019 0.0224 0.0192
Echinococcus multilocularis orexin receptor type 2 0.0026 0.0346 0.0425
Echinococcus multilocularis neuropeptide receptor A26 0.0409 0.7388 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0012 0.0085 0.0106
Toxoplasma gondii eukaryotic initiation factor-4A, putative 0.001 0.0063 0.0136
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0026 0.0346 0.0465
Brugia malayi hypothetical protein 0.0026 0.0346 0.0351
Echinococcus multilocularis tar DNA binding protein 0.0072 0.1191 0.1574
Echinococcus multilocularis rhodopsin orphan GPCR 0.0026 0.0346 0.0425
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0012 0.0098 0.0653
Trichomonas vaginalis DNA helicase recq, putative 0.0018 0.021 0.0177
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0012 0.0085 0.0106
Echinococcus granulosus Alpha N acetylgalactosaminidase 0.005 0.0793 0.1032
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0014 0.0133 0.0295
Trypanosoma cruzi Eukaryotic initiation factor 4A-1 0.001 0.0063 0.0131
Echinococcus multilocularis transcription factor Dp 1 0.0027 0.0364 0.0449
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0046 0.0721 0.0925
Schistosoma mansoni cpg binding protein 0.0013 0.011 0.0145
Plasmodium vivax geranylgeranyl pyrophosphate synthase 0.0248 0.4424 1
Echinococcus multilocularis p2X purinoceptor 4 0.002 0.0238 0.0278
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0026 0.0346 0.0425
Schistosoma mansoni P2X receptor subunit 0.002 0.0238 0.0319
Trypanosoma cruzi ribonuclease H1, putative 0.0019 0.0224 0.0497
Mycobacterium ulcerans polyprenyl diphosphate synthetase, GrcC1 0.0062 0.1021 0.2239
Giardia lamblia Sgs1 DNA helicase, putative 0.0014 0.0133 0.0207
Entamoeba histolytica acyl-coA synthetase, putative 0.0016 0.0174 0.1706
Trypanosoma brucei DNA polymerase eta, putative 0.0022 0.0274 0.0316
Brugia malayi eukaryotic initiation factor 4A 0.001 0.0063 0.0027
Echinococcus granulosus tm gpcr rhodopsin 0.0026 0.0346 0.0425
Brugia malayi hypothetical protein 0.0026 0.0346 0.0351
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0046 0.0721 0.7068
Schistosoma mansoni phosphoglucomutase 0.0019 0.0224 0.0301
Echinococcus granulosus eukaryotic initiation factor 4A III 0.001 0.0063 0.004
Loa Loa (eye worm) hypothetical protein 0.0026 0.0346 0.0388
Trypanosoma cruzi hypothetical protein, conserved 0.0009 0.0042 0.0084
Echinococcus granulosus neuropeptides capa receptor 0.0026 0.0346 0.0425
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0026 0.0346 0.0425
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0014 0.0133 0.0295
Toxoplasma gondii eukaryotic initiation factor-4E, putative 0.0034 0.0505 0.1136
Echinococcus granulosus transcription factor Dp 1 0.0027 0.0364 0.0449
Mycobacterium ulcerans acyl-CoA synthetase 0.0016 0.0174 0.0309
Plasmodium vivax acyl-CoA synthetase, putative 0.0012 0.0098 0.0221
Brugia malayi RNase H family protein 0.0019 0.0224 0.0213
Onchocerca volvulus Telomerase reverse transcriptase homolog 0.0009 0.0042 0.0009
Brugia malayi geranylgeranyl pyrophosphate synthetase 0.0062 0.1021 0.1124
Loa Loa (eye worm) glutathione reductase 0.0014 0.0125 0.0137
Plasmodium vivax SET domain protein, putative 0.007 0.1153 0.2606
Echinococcus granulosus ribonuclease H1 0.0019 0.0224 0.026
Schistosoma mansoni DEAD box ATP-dependent RNA helicase 0.001 0.0063 0.0082
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0016 0.0174 0.0309
Mycobacterium tuberculosis Conserved hypothetical protein 0.0022 0.0274 0.0536
Trypanosoma brucei DNA polymerase IV, putative 0.0022 0.0274 0.0316
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0046 0.0721 0.0974
Onchocerca volvulus Eukaryotic initiation factor 4A homolog 0.001 0.0063 0.003
Brugia malayi cytoplasmic intermediate filament protein 0.0029 0.0397 0.041
Loa Loa (eye worm) G-protein coupled receptor 0.0026 0.0346 0.0388
Plasmodium vivax RNA helicase-1, putative 0.001 0.0063 0.0142
Brugia malayi hypothetical protein 0.0026 0.0346 0.0351
Giardia lamblia Farnesyl diphosphate synthase 0.0248 0.4424 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0016 0.0174 0.0309
Trypanosoma brucei farnesyl pyrophosphate synthase 0.0248 0.4424 0.5969
Echinococcus granulosus p2X purinoceptor 4 0.002 0.0238 0.0278
Trypanosoma cruzi Eukaryotic translation initiation factor 4E-1 0.0034 0.0505 0.1131
Echinococcus multilocularis RNA directed DNA polymerase 0.0009 0.0042 0.0012
Brugia malayi RE15519p 0.0026 0.0346 0.0351
Brugia malayi glutathione reductase 0.0014 0.0125 0.0099
Loa Loa (eye worm) RNA binding protein 0.0072 0.1191 0.1353
Echinococcus granulosus tm gpcr rhodopsin 0.0026 0.0346 0.0425
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0026 0.0346 0.0465
Schistosoma mansoni scy1(yeast) protein kinase-like 0.0009 0.0042 0.0054
Trypanosoma brucei ingi protein (ORF1) 0.0028 0.0395 0.048
Onchocerca volvulus 0.0026 0.0346 0.0313
Mycobacterium ulcerans DNA polymerase IV 0.0022 0.0274 0.0536
Echinococcus granulosus tm gpcr rhodopsin 0.0026 0.0346 0.0425
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0053 0.0855 0.1117
Echinococcus granulosus prenyl decaprenyl diphosphate synthase 0.0062 0.1021 0.1342
Mycobacterium ulcerans hypothetical protein 0.0082 0.1372 0.3039
Echinococcus granulosus neuropeptide Y receptor 0.0026 0.0346 0.0425
Onchocerca volvulus 0.0026 0.0346 0.0313
Schistosoma mansoni P2X receptor subunit 0.002 0.0238 0.0319
Echinococcus multilocularis g protein coupled receptor 0.0026 0.0346 0.0425
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.005 0.0793 0.1071
Brugia malayi Pao retrotransposon peptidase family protein 0.0009 0.0042 0.0004
Trichomonas vaginalis geranylgeranyl pyrophosphate synthase, putative 0.0248 0.4424 0.4405
Schistosoma mansoni gabp alpha 0.0034 0.0505 0.0681
Echinococcus granulosus p2X purinoceptor 4 0.002 0.0238 0.0278
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0026 0.0346 0.0425
Brugia malayi sulfakinin receptor protein 0.0026 0.0346 0.0351
Brugia malayi reverse transcriptase 0.0009 0.0042 0.0004
Schistosoma mansoni neuropeptide F-like receptor 0.0026 0.0346 0.0465
Trypanosoma brucei Eukaryotic initiation factor 4A-1 0.001 0.0063 0.0028
Brugia malayi bHLH-PAS transcription factor 0.0025 0.0331 0.0335
Brugia malayi Doublecortin family protein 0.0012 0.0093 0.0061
Brugia malayi hypothetical protein 0.0009 0.0042 0.0004
Loa Loa (eye worm) hypothetical protein 0.0026 0.0346 0.0388
Echinococcus granulosus RNA directed DNA polymerase reverse transcriptase 0.0009 0.0042 0.0012
Echinococcus multilocularis neuropeptide Y receptor 0.0026 0.0346 0.0425
Brugia malayi AMP-binding enzyme family protein 0.0016 0.0174 0.0155
Loa Loa (eye worm) hypothetical protein 0.0026 0.0346 0.0388
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0274 0.0316
Giardia lamblia Translation initiation factor eIF-4A, putative 0.001 0.0063 0.0047
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0026 0.0346 0.0388
Echinococcus multilocularis G-protein coupled receptor, putative 0.0026 0.0346 0.0425
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0046 0.0721 0.0936
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0026 0.0346 0.0425
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0009 0.0042 0.0012
Schistosoma mansoni DEAD box ATP-dependent RNA helicase 0.001 0.0063 0.0082
Brugia malayi RNA recognition motif domain containing protein 0.0072 0.1191 0.1319
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0073 0.1219 0.1604
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0274 0.0316
Brugia malayi RNase H family protein 0.0019 0.0224 0.0213
Brugia malayi Intermediate filament tail domain containing protein 0.0053 0.0852 0.0931
Schistosoma mansoni lamin 0.0053 0.0852 0.1151
Echinococcus granulosus dna polymerase eta 0.0022 0.0274 0.0327
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0026 0.0346 0.0313
Echinococcus multilocularis neuropeptide Y receptor 0.0026 0.0346 0.0425
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0026 0.0346 0.0388
Mycobacterium ulcerans polyprenyl synthetase IdsB 0.0062 0.1021 0.2239
Trypanosoma brucei unspecified product 0.0015 0.0149 0.0146
Brugia malayi AKH receptor 0.0026 0.0346 0.0351
Brugia malayi G protein-coupled receptor F59B2.13 0.0026 0.0346 0.0351
Brugia malayi Tachykinin-like peptides receptor 99D 0.0026 0.0346 0.0351
Echinococcus multilocularis geminin 0.0192 0.34 0.4577
Loa Loa (eye worm) hypothetical protein 0.0025 0.0327 0.0367
Schistosoma mansoni neuropeptide receptor 0.0026 0.0346 0.0465
Echinococcus granulosus RNA directed DNA polymerase reverse transcriptase 0.0009 0.0042 0.0012
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0026 0.0346 0.0351
Trichomonas vaginalis geranylgeranyl pyrophosphate synthase, putative 0.0248 0.4424 0.4405
Echinococcus granulosus somatostatin receptor 0.0026 0.0346 0.0425
Chlamydia trachomatis endonuclease IV 0.0034 0.0506 0.4788
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0009 0.0042 0.0012
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0026 0.0346 0.0425
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0067 0.1101 0.1451
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0026 0.0346 0.0351
Onchocerca volvulus 0.0049 0.0767 0.0736
Schistosoma mansoni tar DNA-binding protein 0.0072 0.1191 0.161
Brugia malayi hypothetical protein 0.0113 0.1952 0.2191
Schistosoma mansoni lipoxygenase 0.0053 0.0855 0.1155
Echinococcus granulosus neuropeptide receptor 0.0026 0.0346 0.0425
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0026 0.0346 0.0465
Brugia malayi Pao retrotransposon peptidase family protein 0.0009 0.0042 0.0004
Schistosoma mansoni hypothetical protein 0.0026 0.0346 0.0465
Trypanosoma brucei retrotransposon hot spot protein 4 (RHS4), interrupted 0.0028 0.0395 0.048
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.001 0.0063 0.003
Wolbachia endosymbiont of Brugia malayi geranylgeranyl pyrophosphate synthase 0.0062 0.1021 1
Brugia malayi putative neuropeptide receptor NPR1 0.0026 0.0346 0.0351
Echinococcus multilocularis neuropeptides capa receptor 0.0026 0.0346 0.0425
Wolbachia endosymbiont of Brugia malayi geranylgeranyl pyrophosphate synthase 0.0062 0.1021 1
Schistosoma mansoni neuropeptide F-like receptor 0.0026 0.0346 0.0465
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0014 0.0133 0.0136
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0026 0.0346 0.0465
Leishmania major polyprenyl synthase, putative 0.0062 0.1021 0.2249
Mycobacterium tuberculosis Possible polyprenyl synthetase IdsB (polyprenyl transferase) (polyprenyl diphosphate synthase) 0.0062 0.1021 0.2239
Loa Loa (eye worm) hypothetical protein 0.0026 0.0346 0.0388
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0016 0.0174 0.1427
Entamoeba histolytica Flap nuclease, putative 0.003 0.0414 0.4059
Mycobacterium ulcerans geranylgeranyl pyrophosphate synthase 0.0248 0.4424 1
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0009 0.0042 0.0012
Loa Loa (eye worm) hypothetical protein 0.0012 0.0098 0.0106
Echinococcus multilocularis g protein coupled receptor 0.0026 0.0346 0.0425
Brugia malayi Cytochrome P450 family protein 0.0012 0.0089 0.0058
Loa Loa (eye worm) TYRA-2 protein 0.0026 0.0346 0.0388
Loa Loa (eye worm) hypothetical protein 0.0026 0.0346 0.0388
Trypanosoma brucei hypothetical protein, conserved 0.0028 0.0395 0.048
Schistosoma mansoni neuropeptide receptor 0.0026 0.0346 0.0465
Schistosoma mansoni adenoreceptor 0.0026 0.0346 0.0465
Entamoeba histolytica bifunctional short chain isoprenyl diphosphate synthase, putative 0.0062 0.1021 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0174 0.0193
Schistosoma mansoni tar DNA-binding protein 0.0072 0.1191 0.161
Echinococcus granulosus biogenic amine 5HT receptor 0.0026 0.0346 0.0425
Leishmania major flap endonuclease-1 (FEN-1), putative 0.003 0.0414 0.0868
Echinococcus multilocularis geranylgeranyl pyrophosphate synthase 0.0062 0.1021 0.1342
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0149 0.0146
Leishmania major eukaryotic translation initiation factor-like 0.0034 0.0505 0.1074
Leishmania major 4-coumarate:coa ligase-like protein 0.0016 0.0174 0.0321
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0026 0.0346 0.0465
Plasmodium vivax multidomain scavenger receptor, putative 0.0012 0.0093 0.0209
Brugia malayi Pre-SET motif family protein 0.0484 0.8771 1
Plasmodium vivax glutathione reductase, putative 0.0014 0.0125 0.0283
Echinococcus multilocularis neuropeptide receptor 0.0026 0.0346 0.0425
Schistosoma mansoni hypothetical protein 0.0026 0.0346 0.0465
Brugia malayi Cytochrome P450 family protein 0.0012 0.0084 0.0052
Toxoplasma gondii melibiase subfamily protein 0.005 0.0793 0.1787
Trypanosoma cruzi Eukaryotic initiation factor 4A-1 0.001 0.0063 0.0131
Loa Loa (eye worm) cytochrome P450 family protein 0.0012 0.0084 0.009
Entamoeba histolytica deoxycytidyl transferase, putative 0.0022 0.0274 0.2684
Echinococcus multilocularis dna polymerase kappa 0.0022 0.0274 0.0327
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0026 0.0346 0.0425
Entamoeba histolytica eukaryotic translation initiation factor 4E, putative 0.0034 0.0505 0.4946
Echinococcus granulosus g protein coupled receptor 0.0026 0.0346 0.0425
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0016 0.0174 0.0309
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0022 0.0272 0.0605
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0033 0.0486 0.0655
Onchocerca volvulus 0.0026 0.0346 0.0313
Schistosoma mansoni farnesyl pyrophosphate synthase 0.0248 0.4424 0.599
Leishmania major eukaryotic initiation factor 4a, putative 0.001 0.0063 0.0067
Brugia malayi hypothetical protein 0.0009 0.0042 0.0004
Brugia malayi reverse transcriptase 0.0009 0.0042 0.0004

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = -6.27 Inhibitory activity against farnesyl Pyrophosphate Synthase expressed as #NAME? (M) ChEMBL. 14613320
IC50 (binding) = 0.54 uM Inhibitory activity against Leishmania major Farnesyl diphosphate synthase ChEMBL. 14695831
IC50 (binding) = 0.54 uM Inhibitory activity against farnesyl Pyrophosphate Synthase was determined ChEMBL. 14613320
IC50 (binding) = 0.54 uM Inhibitory activity against Leishmania major Farnesyl diphosphate synthase ChEMBL. 14695831
IC50 (binding) = 0.54 uM Inhibitory activity against farnesyl Pyrophosphate Synthase was determined ChEMBL. 14613320
IC50 (functional) = 25 uM Inhibitory activity, for stimulation of TNF-alpha release in gamma-delta T cells, using individual observed maximum TNF-alpha release ChEMBL. 14711309
IC50 (functional) = 35.9 uM In vitro growth inhibition against Entamoeba histolytica ChEMBL. 14695831
IC50 (functional) = 35.9 uM In vitro growth inhibition against Entamoeba histolytica ChEMBL. 14695831
IC50 (functional) = 36 uM Antimicrobial activity against Entamoeba histolytica ChEMBL. 20185316
IC50 (functional) = 55 uM Inhibitory activity, for stimulation of TNF-alpha release in gamma-delta T cells, using a constrained maximum TNF-alpha release of 2700 pg/mL ChEMBL. 14711309
IC50 (functional) = 68.43 uM In vitro inhibitory concentration against the growth of Toxoplasma gondii in human foreskin fibroblast monolayer cells (HFF cells) ChEMBL. 15857119
IC50 (functional) > 200 uM In vitro growth inhibition against Plasmodium falciparum ChEMBL. 14695831
IC50 (functional) > 200 uM In vitro growth inhibition against Plasmodium falciparum ChEMBL. 14695831
IC50 (functional) = 200 uM Antimicrobial activity against Plasmodium falciparum ChEMBL. 20185316
IZ (functional) = 0 mm Antibacterial activity against Escherichia coli W3110 ChEMBL. 17149863
IZ (functional) = 0 mm Antibacterial activity against Escherichia coli W3110 ChEMBL. 17149863
Ki (binding) = 0.052 uM Binding affinity towards farnesyl Pyrophosphate Synthase using [14C]- isopentenyl pyrophosphate as radioligand ChEMBL. 14613320
Ki (binding) = 0.052 uM Binding affinity towards farnesyl Pyrophosphate Synthase using [14C]- isopentenyl pyrophosphate as radioligand ChEMBL. 14613320
LD50 (ADMET) = 629 uM Toxicity evaluated against human nasopharyngeal carcinoma KB cell line ChEMBL. 14695831
LD50 (ADMET) = 629 uM Toxicity evaluated against human nasopharyngeal carcinoma KB cell line ChEMBL. 14695831
LD50 (functional) = 629 uM Lethal dose required to inhibit the growth of human KB (nasopharyngeal carcinoma) cell line ChEMBL. 15857119
Log IC50 (functional) = 4.26 pIC50 value for stimulation of TNF-alpha release in gamma-delta T cells, using a constrained maximum TNF-alpha release of 2700 pg/mL ChEMBL. 14711309
Log IC50 (functional) = 4.6 pIC50 value for stimulation of TNF-alpha release in gamma-delta T cells, using individual observed maximum TNF-alpha release ChEMBL. 14711309
Log IC50 (binding) = 6.27 Inhibitory activity against farnesyl Pyrophosphate Synthase expressed as #NAME? (M) ChEMBL. 14613320
TI (ADMET) = 17.5 Therapeutic index was expressed as ratio of LD50 for KB cell line to IC50 against Entamoeba histolytica ChEMBL. 14695831

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

4 literature references were collected for this gene.

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