Detailed information for compound 831051

Basic information

Technical information
  • TDR Targets ID: 831051
  • Name: N-(4-butylphenyl)-2,4-dimethyl-1,3-thiazole-5 -carboxamide
  • MW: 288.408 | Formula: C16H20N2OS
  • H donors: 1 H acceptors: 2 LogP: 4.8 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCc1ccc(cc1)NC(=O)c1sc(nc1C)C
  • InChi: 1S/C16H20N2OS/c1-4-5-6-13-7-9-14(10-8-13)18-16(19)15-11(2)17-12(3)20-15/h7-10H,4-6H2,1-3H3,(H,18,19)
  • InChiKey: PNQRRPQUOYYCFF-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(4-butylphenyl)-2,4-dimethyl-thiazole-5-carboxamide
  • N-(4-butylphenyl)-2,4-dimethyl-5-thiazolecarboxamide
  • ZINC07995367
  • ST5402892

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) membrane bound O-acyltransferase domain containing 1 0.0022 0.0627 0.0799
Loa Loa (eye worm) hypothetical protein 0.0022 0.0627 0.0799
Loa Loa (eye worm) hypothetical protein 0.0018 0.0428 0.0506
Echinococcus multilocularis protein jagged 1 0.0018 0.0428 0.0076
Mycobacterium ulcerans thioesterase 0.0022 0.0661 0.2064
Brugia malayi Delta serrate ligand family protein 0.0018 0.0428 0.0113
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0026 0.087 0.5182
Trypanosoma cruzi trans-sialidase, Group I, putative 0.0123 0.6504 1
Schistosoma mansoni hypothetical protein 0.0022 0.0627 0.0282
Loa Loa (eye worm) hypothetical protein 0.0018 0.0428 0.0506
Schistosoma mansoni notch 0.0018 0.0428 0.0076
Loa Loa (eye worm) hypothetical protein 0.0056 0.263 0.3755
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0022 0.0627 0.5
Trypanosoma cruzi trans-sialidase, putative 0.0123 0.6503 0.9998
Trypanosoma brucei trans-sialidase, putative 0.0123 0.6504 1
Trypanosoma cruzi GUP1, putative 0.0022 0.0627 0.0443
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.004 0.1679 1
Echinococcus multilocularis peroxidasin 0.0056 0.263 0.2359
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0028 0.1013 0.6033
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0022 0.0627 0.0282
Echinococcus multilocularis protein cysteine N palmitoyltransferase 0.0022 0.0627 0.0282
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0627 0.5
Mycobacterium leprae Probable polyketide synthase Pks1 0.0028 0.1013 0.481
Echinococcus granulosus notch 0.0018 0.0428 0.0076
Trypanosoma cruzi trans-sialidase, putative 0.0123 0.6504 1
Echinococcus granulosus o acyltransferase membrane bound domain 0.0022 0.0627 0.0282
Trypanosoma cruzi trans-sialidase, Group I, putative 0.0123 0.6504 1
Onchocerca volvulus Dual oxidase homolog 0.0056 0.263 1
Onchocerca volvulus Peroxidasin homolog 0.0056 0.263 1
Brugia malayi Hhat protein 0.0022 0.0627 0.0418
Toxoplasma gondii EGF family domain-containing protein 0.0018 0.0428 0.3179
Trypanosoma cruzi trans-sialidase, Group I, putative 0.0123 0.6504 1
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0022 0.0627 0.0282
Onchocerca volvulus 0.0022 0.0627 0.0903
Loa Loa (eye worm) MBOAT family protein 0.0022 0.0627 0.0799
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0143 0.7667 0.7581
Loa Loa (eye worm) hypothetical protein 0.0056 0.263 0.3755
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.0021 0.0616 0.172
Loa Loa (eye worm) hypothetical protein 0.0056 0.263 0.3755
Loa Loa (eye worm) fatty acid synthase 0.0026 0.0897 0.1198
Loa Loa (eye worm) hypothetical protein 0.0056 0.263 0.3755
Echinococcus multilocularis neurogenic locus protein delta 0.0018 0.0428 0.0076
Mycobacterium tuberculosis Probable thioesterase TesA 0.0022 0.0661 0.3934
Echinococcus granulosus slit 2 protein 0.0018 0.0428 0.0076
Giardia lamblia High cysteine protein 0.0018 0.0428 0.5
Trypanosoma brucei trans-sialidase, putative 0.0123 0.6504 1
Brugia malayi Calcium binding EGF domain containing protein 0.0018 0.0428 0.0113
Schistosoma mansoni sterol O-acyltransferase 1 0.0022 0.0627 0.0282
Mycobacterium ulcerans Type I modular polyketide synthase 0.0027 0.0917 0.4065
Schistosoma mansoni hypothetical protein 0.0183 1 1
Echinococcus multilocularis neurogenic locus notch protein 4 0.0018 0.0428 0.0076
Echinococcus granulosus protein jagged 2 0.0018 0.0428 0.0076
Brugia malayi Calcium binding EGF domain containing protein 0.0018 0.0428 0.0113
Trypanosoma cruzi trans-sialidase, Group I, putative 0.0123 0.6504 1
Mycobacterium leprae Polyketide synthase Pks13 0.004 0.1679 1
Trypanosoma cruzi trans-sialidase, putative 0.0123 0.6504 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0428 0.0506
Loa Loa (eye worm) hypothetical protein 0.0018 0.0428 0.0506
Loa Loa (eye worm) hypothetical protein 0.0015 0.024 0.0228
Loa Loa (eye worm) animal heme peroxidase 0.0056 0.263 0.3755
Brugia malayi Animal haem peroxidase family protein 0.0056 0.263 0.3497
Loa Loa (eye worm) animal heme peroxidase 0.0056 0.263 0.3755
Echinococcus granulosus protein jagged 2 0.0018 0.0428 0.0076
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0021 0.0616 0.172
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0028 0.1013 0.481
Loa Loa (eye worm) Notch2 0.0018 0.0428 0.0506
Mycobacterium ulcerans polyketide synthase Pks13 0.004 0.1679 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0428 0.0506
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.005 0.2296 0.2984
Loa Loa (eye worm) hypothetical protein 0.0018 0.0428 0.0506
Plasmodium falciparum diacylglycerol O-acyltransferase 0.0022 0.0627 1
Echinococcus granulosus GPCR family 2 0.0017 0.0366 0.0012
Loa Loa (eye worm) hypothetical protein 0.0018 0.0428 0.0506
Loa Loa (eye worm) diacylglycerol acyltransferase 0.0022 0.0627 0.0799
Loa Loa (eye worm) hypothetical protein 0.0018 0.0428 0.0506
Trypanosoma cruzi trans-sialidase, putative 0.0123 0.6503 0.9998
Onchocerca volvulus 0.0056 0.263 1
Echinococcus granulosus diacylglycerol O acyltransferase 1 0.0022 0.0627 0.0282
Schistosoma mansoni cell polarity protein 0.0018 0.0428 0.0076
Schistosoma mansoni notch 0.0018 0.0428 0.0076
Brugia malayi MBOAT family protein 0.0022 0.0627 0.0418
Echinococcus multilocularis notch 0.0018 0.0428 0.0076
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0018 0.0428 0.0113
Schistosoma mansoni notch 0.0018 0.0428 0.0076
Echinococcus granulosus lysophospholipid acyltransferase 7 0.0022 0.0627 0.0282
Schistosoma mansoni hypothetical protein 0.0018 0.0428 0.0076
Trypanosoma cruzi glycerol uptake protein, putative 0.0022 0.0627 0.0443
Brugia malayi EGF-like domain containing protein 0.0018 0.0428 0.0113
Schistosoma mansoni hypothetical protein 0.0018 0.0428 0.0076
Schistosoma mansoni hypothetical protein 0.0017 0.0366 0.0012
Echinococcus granulosus sterol O acyltransferase 1 0.0022 0.0627 0.0282
Echinococcus multilocularis Membrane bound O acyl transferase, MBOAT 0.0022 0.0627 0.0282
Loa Loa (eye worm) hypothetical protein 0.0017 0.0366 0.0414
Schistosoma mansoni membrane-bound acyltransferase/hhat 0.0022 0.0627 0.0282
Brugia malayi notch-like transmembrane receptor 0.0018 0.0428 0.0113
Trypanosoma cruzi trans-sialidase, Group I, putative 0.0123 0.6504 1
Onchocerca volvulus Peroxidasin homolog 0.0056 0.263 1
Brugia malayi Blistered cuticle protein 3 0.0056 0.263 0.3497
Loa Loa (eye worm) hypothetical protein 0.0056 0.263 0.3755
Trypanosoma cruzi trans-sialidase, putative 0.0123 0.6503 0.9998
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0054 0.2502 0.3301
Leishmania major glycerol uptake protein, putative 0.0022 0.0627 1
Loa Loa (eye worm) hypothetical protein 0.0054 0.2502 0.3567
Brugia malayi EGF-like domain containing protein 0.0018 0.0428 0.0113
Brugia malayi Calcium binding EGF domain containing protein 0.0018 0.0428 0.0113
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0027 0.0917 0.5463
Echinococcus granulosus protein cysteine N palmitoyltransferase 0.0022 0.0627 0.0282
Schistosoma mansoni notch 0.0018 0.0428 0.0076
Trypanosoma brucei trans-sialidase 0.0123 0.6504 1
Treponema pallidum alginate O-acetylation protein (algI) 0.0022 0.0627 0.5
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0025 0.0816 0.1078
Echinococcus multilocularis neurogenic locus notch protein 0.0018 0.0428 0.0076
Trypanosoma brucei trans-sialidase, putative 0.0123 0.6504 1
Leishmania major hypothetical protein, conserved 0.0022 0.0627 1
Schistosoma mansoni hypothetical protein 0.0018 0.0428 0.0076
Schistosoma mansoni peroxidasin 0.0056 0.263 0.2359
Echinococcus granulosus neurogenic locus protein delta 0.0018 0.0428 0.0076
Loa Loa (eye worm) hypothetical protein 0.0018 0.0428 0.0506
Onchocerca volvulus 0.0025 0.0816 0.1762
Loa Loa (eye worm) MBOAT family protein 0.0022 0.0627 0.0799
Entamoeba histolytica vacuolar protein sorting 26 0.0022 0.0627 0.5
Brugia malayi Animal haem peroxidase family protein 0.0056 0.263 0.3497
Brugia malayi Animal haem peroxidase family protein 0.0056 0.263 0.3497
Mycobacterium tuberculosis Polyketide synthase Pks13 0.004 0.1679 1
Schistosoma mansoni hypothetical protein 0.0017 0.0366 0.0012
Echinococcus multilocularis membrane bound acyltransferase:hhat 0.0022 0.0627 0.0282
Loa Loa (eye worm) hypothetical protein 0.0022 0.0627 0.0799
Onchocerca volvulus Peroxidase homolog 0.0056 0.263 1
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0028 0.1013 0.481
Trypanosoma cruzi trans-sialidase, Group I, putative 0.0123 0.6504 1
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0355 0.2322
Echinococcus multilocularis lysophospholipid acyltransferase 7 0.0022 0.0627 0.0282
Loa Loa (eye worm) hypothetical protein 0.0018 0.0428 0.0506
Onchocerca volvulus 0.0056 0.263 1
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.0017 0.0376 0.2574
Brugia malayi hypothetical protein 0.0056 0.263 0.3497
Brugia malayi MBOAT family protein 0.0022 0.0627 0.0418
Loa Loa (eye worm) hypothetical protein 0.0056 0.263 0.3755
Echinococcus multilocularis fibropellin Ia 0.0018 0.0428 0.0076
Leishmania major glycerol uptake protein, putative 0.0022 0.0627 1
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0022 0.0627 0.0282
Loa Loa (eye worm) MBOAT family protein 0.0022 0.0627 0.0799
Trypanosoma cruzi trans-sialidase, Group I, putative 0.0123 0.6504 1
Brugia malayi GCC2 and GCC3 family protein 0.0018 0.0428 0.0113
Loa Loa (eye worm) hypothetical protein 0.0037 0.1514 0.2108
Mycobacterium tuberculosis Probable polyketide synthase Pks9 0.0015 0.0253 0.1505
Loa Loa (eye worm) hypothetical protein 0.0022 0.0627 0.0799
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.0022 0.0661 0.2064
Echinococcus multilocularis neural cadherin 0.0018 0.0428 0.0076
Echinococcus granulosus nuclear factor of activated T cells 5 0.0143 0.7667 0.7581
Schistosoma mansoni zinc finger protein 0.0022 0.0627 0.0282
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0017 0.0366 0.0012
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0027 0.0917 0.5463
Echinococcus multilocularis neurogenic locus notch protein 0.0018 0.0428 0.0076
Trypanosoma cruzi trans-sialidase, Group I, putative 0.0123 0.6504 1
Echinococcus granulosus protein jagged 1 0.0018 0.0428 0.0076
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0025 0.0816 0.4861
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0027 0.0917 0.0865
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0017 0.0366 0.0012
Echinococcus granulosus fibropellin Ia 0.0018 0.0428 0.0076
Onchocerca volvulus 0.0046 0.2058 0.7401
Mycobacterium ulcerans polyketide synthase 0.0028 0.1013 0.481
Plasmodium vivax diacylglycerol O-acyltransferase, putative 0.0022 0.0627 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.0627 0.0799
Schistosoma mansoni diacylglycerol O-acyltransferase 1 0.0022 0.0627 0.0282
Trypanosoma brucei trans-sialidase, putative 0.0123 0.6504 1
Onchocerca volvulus Fatty acid synthase homolog 0.0048 0.2154 0.7836
Echinococcus granulosus peroxidasin 0.0056 0.263 0.2359
Loa Loa (eye worm) hypothetical protein 0.0045 0.1965 0.2773
Schistosoma mansoni hypothetical protein 0.0037 0.1514 0.1201
Toxoplasma gondii type I fatty acid synthase, putative 0.0028 0.1013 1
Echinococcus multilocularis diacylglycerol O acyltransferase 1 0.0022 0.0627 0.0282
Loa Loa (eye worm) hypothetical protein 0.0018 0.0428 0.0506
Loa Loa (eye worm) hypothetical protein 0.0018 0.0428 0.0506
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0816 0.0709
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.0027 0.0917 0.4065
Loa Loa (eye worm) hhat protein 0.0022 0.0627 0.0799
Schistosoma mansoni septate junction protein 0.0018 0.0428 0.0076
Loa Loa (eye worm) hypothetical protein 0.0018 0.0428 0.0506
Loa Loa (eye worm) notch protein 0.0018 0.0428 0.0506
Echinococcus multilocularis protein jagged 2 0.0018 0.0428 0.0076
Schistosoma mansoni hypothetical protein 0.0017 0.0366 0.0012
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0022 0.0627 0.0282
Loa Loa (eye worm) hypothetical protein 0.0056 0.263 0.3755
Brugia malayi Latrophilin receptor protein 2 0.0017 0.0366 0.0017
Toxoplasma gondii acyl-CoA:diacylglycerol acyltransferase 1-related enzyme 0.0022 0.0627 0.5497
Onchocerca volvulus 0.0056 0.263 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0017 0.0366 0.0012
Toxoplasma gondii acyl-CoA:cholesterol acyltransferase alpha ACAT1-alpha 0.0022 0.0627 0.5497
Mycobacterium ulcerans Type I modular polyketide synthase 0.0027 0.0917 0.4065
Trypanosoma cruzi trans-sialidase, Group I, putative 0.0123 0.6504 1
Brugia malayi Animal haem peroxidase family protein 0.0056 0.263 0.3497
Schistosoma mansoni hypothetical protein 0.0183 1 1
Mycobacterium ulcerans polyketide synthase 0.0027 0.0917 0.4065
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0021 0.0616 0.172
Trichomonas vaginalis porcupine, putative 0.0022 0.0627 0.5
Brugia malayi MBOAT family protein 0.0022 0.0627 0.0418
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0027 0.0917 0.5463
Loa Loa (eye worm) hypothetical protein 0.0018 0.0428 0.0506
Echinococcus granulosus o acyltransferase membrane bound domain 0.0022 0.0627 0.0282
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0028 0.1013 0.481
Loa Loa (eye worm) animal heme peroxidase 0.0056 0.263 0.3755
Schistosoma mansoni hypothetical protein 0.0017 0.0366 0.0012
Trypanosoma cruzi trans-sialidase, putative 0.0123 0.6504 1
Toxoplasma gondii type I fatty acid synthase, putative 0.0019 0.0474 0.3708
Echinococcus granulosus membrane bound acyltransferase:hhat 0.0022 0.0627 0.0282
Loa Loa (eye worm) latrophilin receptor protein 2 0.0017 0.0366 0.0414
Schistosoma mansoni hypothetical protein 0.0018 0.0428 0.0076
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0026 0.087 0.5182
Echinococcus granulosus delta-like protein 1 0.0018 0.0428 0.0076
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0355 0.2322
Echinococcus granulosus protein jagged 1 0.0018 0.0428 0.0076
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0022 0.0627 0.0282
Entamoeba histolytica hypothetical protein, conserved 0.0022 0.0627 0.5
Schistosoma mansoni hypothetical protein 0.0018 0.0428 0.0076
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0627 0.5
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0019 0.0484 0.288
Trypanosoma cruzi GUP1, putative 0.0022 0.0627 0.0443
Echinococcus multilocularis sterol O acyltransferase 1 0.0022 0.0627 0.0282
Brugia malayi EGF-like domain containing protein 0.0018 0.0428 0.0113
Loa Loa (eye worm) MH2 domain-containing protein 0.0129 0.6861 1
Schistosoma mansoni notch 0.0018 0.0428 0.0076
Trypanosoma brucei glycerol uptake protein, putative 0.0022 0.0627 0.0443
Loa Loa (eye worm) hypothetical protein 0.0018 0.0428 0.0506
Loa Loa (eye worm) hypothetical protein 0.0056 0.263 0.3755
Brugia malayi Calcitonin receptor-like protein seb-1 0.0054 0.2502 0.3301
Brugia malayi Cadherin domain containing protein 0.0018 0.0428 0.0113
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0022 0.0627 0.0282
Schistosoma mansoni Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] 0.0018 0.0428 0.0076
Entamoeba histolytica hypothetical protein 0.0022 0.0627 0.5
Loa Loa (eye worm) blistered cuticle protein 3 0.0056 0.263 0.3755
Leishmania major glycerol uptake protein, putative 0.0022 0.0627 1
Schistosoma mansoni notch 0.0018 0.0428 0.0076
Brugia malayi EGF-like domain containing protein 0.0018 0.0428 0.0113
Loa Loa (eye worm) hypothetical protein 0.0018 0.0428 0.0506
Loa Loa (eye worm) transcription factor SMAD2 0.0129 0.6861 1
Echinococcus granulosus neurogenic locus notch protein 4 0.0018 0.0428 0.0076
Loa Loa (eye worm) hypothetical protein 0.0018 0.0428 0.0506
Loa Loa (eye worm) hypothetical protein 0.0018 0.0428 0.0506
Trypanosoma cruzi trans-sialidase, Group I, putative 0.0123 0.6504 1
Echinococcus granulosus neurogenic locus notch protein 0.0018 0.0428 0.0076
Echinococcus multilocularis slit 2 protein 0.0018 0.0428 0.0076
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0028 0.1013 0.481
Onchocerca volvulus Peroxidase homolog 0.0056 0.263 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0428 0.0506
Brugia malayi latrophilin 2 splice variant baaae 0.0037 0.1514 0.1781
Loa Loa (eye worm) hypothetical protein 0.0018 0.0428 0.0506
Brugia malayi MH2 domain containing protein 0.0129 0.6861 1
Trypanosoma cruzi glycerol uptake protein, putative 0.0022 0.0627 0.0443
Loa Loa (eye worm) hypothetical protein 0.0018 0.0428 0.0506
Brugia malayi Cadherin domain containing protein 0.0018 0.0428 0.0113
Echinococcus multilocularis neurogenic locus protein delta 0.0018 0.0428 0.0076
Brugia malayi MBOAT family protein 0.0022 0.0627 0.0418
Trichomonas vaginalis transmembrane protein nessy, putative 0.0022 0.0627 0.5
Loa Loa (eye worm) isocitrate dehydrogenase 0.0017 0.0355 0.0397
Echinococcus granulosus Membrane bound O acyl transferase MBOAT 0.0022 0.0627 0.0282
Loa Loa (eye worm) hypothetical protein 0.0056 0.263 0.3755
Trypanosoma cruzi trans-sialidase, putative 0.0123 0.6503 0.9998
Echinococcus multilocularis geminin 0.0183 1 1
Schistosoma mansoni leukocyte receptor cluster (lrc) member 4 protein 0.0022 0.0627 0.0282
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.0022 0.0637 0.3792
Brugia malayi EGF-like domain containing protein 0.0018 0.0428 0.0113
Mycobacterium ulcerans Type I modular polyketide synthase 0.0027 0.0917 0.4065
Onchocerca volvulus Chorion peroxidase homolog 0.0056 0.263 1
Trypanosoma brucei glycerol uptake protein, putative 0.0022 0.0627 0.0443
Brugia malayi Animal haem peroxidase family protein 0.0056 0.263 0.3497
Echinococcus granulosus o acyltransferase membrane bound domain 0.0022 0.0627 0.0282
Schistosoma mansoni slit 0.0018 0.0428 0.0076
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0022 0.0627 0.5
Loa Loa (eye worm) animal heme peroxidase 0.0056 0.263 0.3755
Loa Loa (eye worm) hypothetical protein 0.0018 0.0428 0.0506
Brugia malayi MBOAT family protein 0.0022 0.0627 0.0418
Brugia malayi EGF-like domain containing protein 0.0018 0.0428 0.0113
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0022 0.0627 0.5
Brugia malayi EGF-like domain containing protein 0.0018 0.0428 0.0113
Trypanosoma brucei trans-sialidase, putative 0.0123 0.6504 1
Loa Loa (eye worm) hypothetical protein 0.0056 0.263 0.3755
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0054 0.2502 0.3567
Echinococcus multilocularis GPCR, family 2 0.0017 0.0366 0.0012
Leishmania major glycerol uptake protein, putative 0.0022 0.0627 1
Echinococcus multilocularis fat cadherin tumor suppressor 0.0018 0.0428 0.0076
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0028 0.1013 0.6033
Loa Loa (eye worm) hypothetical protein 0.0056 0.263 0.3755
Brugia malayi Muscle positioning protein 4 0.0018 0.0428 0.0113
Echinococcus granulosus neural cadherin 0.0018 0.0428 0.0076
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0027 0.0917 0.4065
Leishmania major glycerol uptake protein, putative 0.0022 0.0627 1
Trypanosoma cruzi glycerol uptake protein, putative 0.0022 0.0627 0.0443
Schistosoma mansoni hypothetical protein 0.0018 0.0428 0.0076
Trypanosoma cruzi trans-sialidase, Group I, putative 0.0123 0.6504 1
Schistosoma mansoni peroxidasin 0.0056 0.263 0.2359
Echinococcus multilocularis protein jagged 1 0.0018 0.0428 0.0076
Schistosoma mansoni laminin gamma-3 chain 0.0018 0.0428 0.0076
Brugia malayi Peroxidasin 0.0056 0.263 0.3497
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0017 0.0366 0.0017
Loa Loa (eye worm) hypothetical protein 0.0056 0.263 0.3755
Mycobacterium ulcerans thioesterase TesA 0.0022 0.0661 0.2064
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0028 0.1013 0.6033
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.0027 0.0917 0.4065
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0627 0.5
Loa Loa (eye worm) hypothetical protein 0.0056 0.263 0.3755
Loa Loa (eye worm) hhat protein 0.0022 0.0627 0.0799
Toxoplasma gondii hypothetical protein 0.0022 0.0627 0.5497
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0017 0.0355 0.2112
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0017 0.0366 0.0012
Schistosoma mansoni hypothetical protein 0.0018 0.0428 0.0076
Loa Loa (eye worm) hypothetical protein 0.0056 0.263 0.3755
Echinococcus granulosus neurogenic locus notch protein 0.0018 0.0428 0.0076
Brugia malayi diacylglycerol acyltransferase 0.0022 0.0627 0.0418

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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