Detailed information for compound 843414

Basic information

Technical information
  • TDR Targets ID: 843414
  • Name: N-(3-chlorophenyl)-2-[(4-oxo-3-propan-2-yl-[1 ]benzoxolo[3,2-d]pyrimidin-2-yl)sulfanyl]acet amide
  • MW: 427.904 | Formula: C21H18ClN3O3S
  • H donors: 1 H acceptors: 2 LogP: 4.89 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Nc1cccc(c1)Cl)CSc1nc2c(c(=O)n1C(C)C)oc1c2cccc1
  • InChi: 1S/C21H18ClN3O3S/c1-12(2)25-20(27)19-18(15-8-3-4-9-16(15)28-19)24-21(25)29-11-17(26)23-14-7-5-6-13(22)10-14/h3-10,12H,11H2,1-2H3,(H,23,26)
  • InChiKey: UVQKGDPSORCTGR-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(3-chlorophenyl)-2-(3-isopropyl-4-oxo-benzofurano[3,2-d]pyrimidin-2-yl)sulfanyl-acetamide
  • N-(3-chlorophenyl)-2-[(3-isopropyl-4-oxo-2-benzofurano[3,2-d]pyrimidinyl)thio]acetamide
  • N-(3-chlorophenyl)-2-[(3-isopropyl-4-keto-benzofurano[3,2-d]pyrimidin-2-yl)thio]acetamide
  • N-(3-chlorophenyl)-2-[(4-oxo-3-propan-2-yl-[1]benzoxolo[3,2-d]pyrimidin-2-yl)sulfanyl]ethanamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) phosphofructokinase 0.0106 0.142 0.4283
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0106 0.142 0.9834
Schistosoma mansoni hypothetical protein 0.0015 0.0075 0.013
Trypanosoma cruzi polypeptide deformylase-like protein, putative 0.0092 0.1214 0.8331
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0125 0.0369
Echinococcus granulosus SAM and MBT domain containing protein 0.0046 0.0541 0.0942
Trichomonas vaginalis phosphofructokinase, putative 0.0106 0.142 0.9827
Loa Loa (eye worm) hypothetical protein 0.0043 0.0492 0.1485
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0511 0.0889
Schistosoma mansoni ap endonuclease 0.0018 0.0125 0.0218
Brugia malayi MH2 domain containing protein 0.0016 0.009 0.0272
Loa Loa (eye worm) cytochrome P450 family protein 0.0025 0.023 0.0693
Loa Loa (eye worm) hypothetical protein 0.0037 0.0407 0.1228
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0044 0.0511 0.154
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0017 0.0109 0.019
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0107 0.1442 0.1334
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0106 0.142 0.9834
Entamoeba histolytica phosphofructokinase, putative 0.0106 0.142 1
Brugia malayi beta-lactamase 0.0107 0.1442 0.4352
Echinococcus multilocularis zinc finger protein 0.0021 0.016 0.0278
Entamoeba histolytica hypothetical protein 0.0071 0.0901 0.5993
Echinococcus multilocularis histone acetyltransferase MYST2 0.0053 0.0636 0.1108
Echinococcus granulosus smad 0.0016 0.009 0.0157
Trypanosoma cruzi Peptide deformylase 2, putative 0.0092 0.1214 0.8331
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0106 0.142 0.1311
Mycobacterium ulcerans esterase/lipase LipP 0.0107 0.1442 0.4079
Brugia malayi MH1 domain containing protein 0.0016 0.009 0.0272
Echinococcus multilocularis polycomb protein SCMH1 0.0046 0.0541 0.0942
Entamoeba histolytica hypothetical protein 0.0071 0.0901 0.5993
Trichomonas vaginalis phosphofructokinase, putative 0.0106 0.142 0.9827
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0107 0.1442 0.1334
Schistosoma mansoni Smad4 0.0016 0.009 0.0157
Brugia malayi MH2 domain containing protein 0.0234 0.3315 1
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0125 0.0378
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0125 0.0369
Treponema pallidum polypeptide deformylase (def) 0.0241 0.3418 1
Echinococcus multilocularis mothers against decapentaplegic 5 0.0016 0.009 0.0157
Mycobacterium tuberculosis Conserved protein 0.0107 0.1442 0.1334
Brugia malayi Cytochrome P450 family protein 0.0025 0.023 0.0693
Schistosoma mansoni smad1 5 8 and 0.0016 0.009 0.0157
Entamoeba histolytica hypothetical protein 0.0071 0.0901 0.5993
Entamoeba histolytica phosphofructokinase, putative 0.0106 0.142 1
Trypanosoma cruzi Peptide deformylase 2, putative 0.0092 0.1214 0.8331
Loa Loa (eye worm) hypothetical protein 0.004 0.0441 0.1331
Mycobacterium ulcerans beta-lactamase 0.0107 0.1442 0.4079
Echinococcus granulosus 6 phosphofructokinase 0.0106 0.142 0.2471
Schistosoma mansoni sex comb on midleg homolog 0.0046 0.0541 0.0942
Loa Loa (eye worm) cytochrome P450 family protein 0.0015 0.0082 0.0246
Plasmodium vivax ataxin-2 like protein, putative 0.0024 0.0216 0.0276
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0511 0.0889
Mycobacterium ulcerans 6-phosphofructokinase 0.0106 0.142 0.4011
Loa Loa (eye worm) hypothetical protein 0.0107 0.1442 0.4352
Chlamydia trachomatis peptide deformylase 0.0241 0.3418 1
Schistosoma mansoni sex comb on midleg homolog 0.0046 0.0541 0.0942
Trypanosoma brucei PAB1-binding protein , putative 0.0024 0.0216 0.1033
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0511 0.0889
Schistosoma mansoni hypothetical protein 0.0071 0.0901 0.1569
Mycobacterium leprae Probable lipase LipE 0.0107 0.1442 0.0114
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0016 0.009 0.0157
Leishmania major cytochrome p450-like protein 0.0015 0.0082 0.005
Trypanosoma cruzi polypeptide deformylase-like protein, putative 0.0092 0.1214 0.8331
Echinococcus granulosus fetal alzheimer antigen falz 0.0024 0.0203 0.0353
Brugia malayi Smad1 0.0016 0.009 0.0272
Toxoplasma gondii ABC1 family protein 0.0107 0.1442 0.4
Onchocerca volvulus 0.0028 0.0268 0.1858
Trichomonas vaginalis D-aminoacylase, putative 0.0107 0.1442 1
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0107 0.1442 0.4079
Mycobacterium tuberculosis Probable lipase LipD 0.0107 0.1442 0.1334
Echinococcus granulosus histone lysine methyltransferase setb 0.0017 0.0109 0.019
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0107 0.1442 0.2511
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0107 0.1442 0.2511
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0511 0.0889
Echinococcus multilocularis beta LACTamase domain containing family member 0.0107 0.1442 0.2511
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0277 0.0462
Leishmania major hypothetical protein, conserved 0.0107 0.1442 1
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.01 0.0174
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0035 0.0372 0.0647
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0187 0.2616 0.4554
Loa Loa (eye worm) hypothetical protein 0.0048 0.0567 0.171
Trypanosoma cruzi hypothetical protein, conserved 0.0107 0.1442 1
Trichomonas vaginalis D-aminoacylase, putative 0.0107 0.1442 1
Onchocerca volvulus 0.0107 0.1442 1
Brugia malayi MH2 domain containing protein 0.0016 0.009 0.0272
Schistosoma mansoni hypothetical protein 0.0286 0.4085 0.7111
Loa Loa (eye worm) MH2 domain-containing protein 0.0016 0.009 0.0272
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0511 0.0889
Loa Loa (eye worm) MBCTL1 0.0053 0.0636 0.192
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0029 0.0277 0.1175
Onchocerca volvulus 0.0048 0.0567 0.3928
Loa Loa (eye worm) bromodomain containing protein 0.0017 0.0109 0.0328
Loa Loa (eye worm) CYP4Cod1 0.0015 0.0082 0.0246
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0216 0.1033
Schistosoma mansoni hypothetical protein 0.0011 0.0017 0.0029
Loa Loa (eye worm) PHD-finger family protein 0.002 0.0152 0.0457
Schistosoma mansoni smad1 5 8 and 0.0016 0.009 0.0157
Trichomonas vaginalis penicillin-binding protein, putative 0.0107 0.1442 1
Schistosoma mansoni smad1 5 8 and 0.0016 0.009 0.0157
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0029 0.0277 0.1154
Brugia malayi 6-phosphofructokinase 0.0106 0.142 0.4283
Schistosoma mansoni cpg binding protein 0.0031 0.0319 0.0556
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0011 0.0017 0.0029
Entamoeba histolytica phosphofructokinase, putative 0.0106 0.142 1
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0277 0.1154
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0107 0.1442 0.4352
Schistosoma mansoni hypothetical protein 0.0398 0.5744 1
Brugia malayi beta-lactamase family protein 0.0107 0.1442 0.4352
Mycobacterium leprae conserved hypothetical protein 0.0107 0.1442 0.0114
Loa Loa (eye worm) beta-lactamase 0.0107 0.1442 0.4352
Echinococcus multilocularis tumor protein p63 0.0329 0.472 0.8217
Mycobacterium tuberculosis Conserved protein 0.0107 0.1442 0.1334
Brugia malayi beta-lactamase family protein 0.0107 0.1442 0.4352
Leishmania major ATP-dependent phosphofructokinase 0.0106 0.142 0.9834
Echinococcus granulosus mothers against decapentaplegic 5 0.0016 0.009 0.0157
Onchocerca volvulus 0.0046 0.0541 0.3753
Trypanosoma cruzi cytochrome P450, putative 0.0015 0.0082 0.005
Wolbachia endosymbiont of Brugia malayi peptide deformylase 0.0241 0.3418 1
Brugia malayi hypothetical protein 0.0071 0.0901 0.2719
Brugia malayi Cytochrome P450 family protein 0.0015 0.0082 0.0246
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0277 0.0462
Loa Loa (eye worm) MH2 domain-containing protein 0.0234 0.3315 1
Mycobacterium leprae PROBABLE POLYPEPTIDE DEFORMYLASE DEF (PDF) (FORMYLMETHIONINE DEFORMYLASE) 0.0241 0.3418 1
Trypanosoma cruzi cytochrome P450, putative 0.0015 0.0082 0.005
Echinococcus granulosus dnaJ subfamily B 0.0398 0.5744 1
Echinococcus granulosus tumor protein p63 0.0329 0.472 0.8217
Trichomonas vaginalis esterase, putative 0.0107 0.1442 1
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0125 0.0378
Schistosoma mansoni cpg binding protein 0.0028 0.0268 0.0467
Echinococcus granulosus zinc finger protein 0.0021 0.016 0.0278
Plasmodium vivax peptide deformylase, putative 0.0241 0.3418 1
Onchocerca volvulus 0.0107 0.1442 1
Brugia malayi F/Y-rich N-terminus family protein 0.001 0.0008 0.0025
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.006 0.0738 0.1284
Loa Loa (eye worm) hypothetical protein 0.0107 0.1442 0.4352
Leishmania major polypeptide deformylase-like protein, putative 0.0092 0.1214 0.8331
Mycobacterium tuberculosis Probable polypeptide deformylase Def (PDF) (formylmethionine deformylase) 0.0241 0.3418 0.3334
Loa Loa (eye worm) hypothetical protein 0.0107 0.1442 0.4352
Trypanosoma brucei Polypeptide deformylase 1 0.0092 0.1214 0.8331
Trypanosoma brucei cytochrome P450, putative 0.0015 0.0082 0.005
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0024 0.0203 0.0353
Brugia malayi CXXC zinc finger family protein 0.0028 0.0268 0.0809
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0018 0.0125 0.0131
Trichomonas vaginalis penicillin-binding protein, putative 0.0107 0.1442 1
Schistosoma mansoni bromodomain containing protein 0.0063 0.0789 0.1374
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0216 0.0276
Schistosoma mansoni cellular tumor antigen P53 0.0048 0.0567 0.0986
Loa Loa (eye worm) hypothetical protein 0.0069 0.0873 0.2633
Mycobacterium ulcerans lipase LipD 0.0107 0.1442 0.4079
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0511 0.0889
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0029 0.0277 0.0462
Toxoplasma gondii histone lysine methyltransferase SET1 0.0055 0.0672 0.1661
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0024 0.0203 0.0353
Mycobacterium ulcerans peptide deformylase 0.0241 0.3418 1
Brugia malayi mbt repeat family protein 0.0046 0.0541 0.1633
Echinococcus multilocularis Smad4 0.0016 0.009 0.0157
Echinococcus multilocularis cpg binding protein 0.0031 0.0319 0.0556
Toxoplasma gondii LsmAD domain-containing protein 0.0024 0.0216 0.0276
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0046 0.0541 0.3753
Plasmodium falciparum peptide deformylase 0.0241 0.3418 1
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0268 0.0809
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0277 0.0462
Mycobacterium ulcerans hypothetical protein 0.0107 0.1442 0.4079
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.006 0.0738 0.1284
Brugia malayi Bromodomain containing protein 0.0037 0.0406 0.1225
Schistosoma mansoni smad 0.0016 0.009 0.0157
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0106 0.142 0.3931
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0017 0.0109 0.019
Onchocerca volvulus 0.0107 0.1442 1
Schistosoma mansoni zinc finger protein 0.0021 0.016 0.0278
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0125 0.0218
Echinococcus granulosus Smad4 0.0016 0.009 0.0157
Brugia malayi Bromodomain containing protein 0.0075 0.0958 0.289
Schistosoma mansoni transcription factor LCR-F1 0.0071 0.0901 0.1569
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0511 0.0889
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0277 0.0462
Loa Loa (eye worm) 6-phosphofructokinase 0.0106 0.142 0.4283
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0216 0.0276
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0044 0.0511 0.154
Echinococcus multilocularis SAM and MBT domain containing protein 0.0046 0.0541 0.0942
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.01 0.0174
Schistosoma mansoni 6-phosphofructokinase 0.0106 0.142 0.2471
Brugia malayi Cytochrome P450 family protein 0.0015 0.0082 0.0246
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0071 0.0901 0.1569
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0029 0.0277 1
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0277 0.1154
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0059 0.0732 0.1274
Mycobacterium tuberculosis Conserved protein 0.0107 0.1442 0.1334
Entamoeba histolytica hypothetical protein 0.0071 0.0901 0.5993
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0029 0.0277 0.0462
Schistosoma mansoni ap endonuclease 0.0018 0.0125 0.0218
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0107 0.1442 0.4352
Mycobacterium tuberculosis Probable lipase LipE 0.0107 0.1442 0.1334
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0277 0.1154
Schistosoma mansoni zinc finger protein 0.0015 0.0075 0.013
Schistosoma mansoni 6-phosphofructokinase 0.0106 0.142 0.2471
Schistosoma mansoni myelin transcription factor 1 myt1 0.0053 0.0636 0.1108
Trichomonas vaginalis phosphofructokinase, putative 0.0106 0.142 0.9827
Loa Loa (eye worm) Smad1 0.0016 0.009 0.0272
Trichomonas vaginalis phosphofructokinase, putative 0.0106 0.142 0.9827
Brugia malayi MH1 domain containing protein 0.0016 0.009 0.0272
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0053 0.0636 0.1108
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0277 0.1154
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0125 0.0369
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0016 0.009 0.0157
Loa Loa (eye worm) hypothetical protein 0.0046 0.0541 0.1633
Plasmodium vivax hypothetical protein, conserved 0.0107 0.1442 0.4
Loa Loa (eye worm) 6-phosphofructokinase 0.0106 0.142 0.4283
Leishmania major hypothetical protein, conserved 0.0024 0.0216 0.1033
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0053 0.0636 0.1108
Loa Loa (eye worm) MH1 domain-containing protein 0.0016 0.009 0.0272
Echinococcus granulosus histone acetyltransferase MYST2 0.0053 0.0636 0.1108
Brugia malayi phosphofructokinase 0.0106 0.142 0.4283
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0011 0.0017 0.0029
Schistosoma mansoni cpg binding protein 0.0031 0.0319 0.0556
Echinococcus multilocularis dnaJ subfamily B 0.0398 0.5744 1
Brugia malayi hypothetical protein 0.0016 0.0088 0.0265
Loa Loa (eye worm) hypothetical protein 0.0107 0.1442 0.4352
Echinococcus granulosus TGF beta signal transducer SmadC 0.0016 0.009 0.0157
Trichomonas vaginalis D-aminoacylase, putative 0.0107 0.1442 1
Loa Loa (eye worm) hypothetical protein 0.0107 0.1442 0.4352
Mycobacterium tuberculosis Probable esterase LipL 0.0107 0.1442 0.1334
Trypanosoma cruzi hypothetical protein, conserved 0.0107 0.1442 1
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0017 0.01 0.0174
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0046 0.0541 0.0942
Loa Loa (eye worm) mbt repeat family protein 0.0046 0.0541 0.1633
Echinococcus granulosus cpg binding protein 0.0031 0.0319 0.0556
Brugia malayi PHD-finger family protein 0.0026 0.0237 0.0714
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0017 0.0109 0.019
Schistosoma mansoni hypothetical protein 0.002 0.0152 0.0264
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0216 0.1033
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.01 0.0174
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0107 0.1442 0.1334
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0277 0.1154
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0277 0.1154
Brugia malayi hypothetical protein 0.0024 0.0216 0.0652
Loa Loa (eye worm) hypothetical protein 0.0107 0.1442 0.4352
Trypanosoma brucei Peptide deformylase 2 0.0092 0.1214 0.8331
Echinococcus granulosus polycomb protein SCMH1 0.0046 0.0541 0.0942
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0125 0.0369
Echinococcus multilocularis smad 0.0016 0.009 0.0157
Toxoplasma gondii hypothetical protein 0.0241 0.3418 1
Loa Loa (eye worm) transcription factor SMAD2 0.0234 0.3315 1
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0187 0.2616 0.4554
Trypanosoma brucei hypothetical protein, conserved 0.0107 0.1442 1
Brugia malayi mbt repeat family protein 0.0046 0.0541 0.1633
Mycobacterium tuberculosis Probable hydrolase 0.0107 0.1442 0.1334
Toxoplasma gondii 6-phosphofructokinase 0.0029 0.0277 0.0462
Echinococcus multilocularis 6 phosphofructokinase 0.0106 0.142 0.2471
Brugia malayi 6-phosphofructokinase 0.0106 0.142 0.4283
Loa Loa (eye worm) cytochrome P450 family protein 0.0015 0.0082 0.0246
Loa Loa (eye worm) hypothetical protein 0.0024 0.0216 0.0652
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0071 0.0901 0.1569
Echinococcus granulosus beta LACTamase domain containing family member 0.0107 0.1442 0.2511
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0053 0.0636 0.192
Loa Loa (eye worm) hypothetical protein 0.0017 0.0109 0.0329
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0125 0.0218
Toxoplasma gondii phosphofructokinase PFKII 0.0029 0.0277 0.0462
Loa Loa (eye worm) hypothetical protein 0.0053 0.0636 0.192
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0035 0.0372 0.0647

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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