Detailed information for compound 845485

Basic information

Technical information
  • TDR Targets ID: 845485
  • Name: 3-(4-ethylphenyl)-1-(4-methyl-3-oxo-1,4-benzo thiazin-6-yl)urea
  • MW: 341.427 | Formula: C18H19N3O2S
  • H donors: 2 H acceptors: 2 LogP: 2.96 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCc1ccc(cc1)NC(=O)Nc1ccc2c(c1)N(C)C(=O)CS2
  • InChi: 1S/C18H19N3O2S/c1-3-12-4-6-13(7-5-12)19-18(23)20-14-8-9-16-15(10-14)21(2)17(22)11-24-16/h4-10H,3,11H2,1-2H3,(H2,19,20,23)
  • InChiKey: OZHGRZAHCQCAIX-UHFFFAOYSA-N  


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Synonyms

  • 3-(4-ethylphenyl)-1-(3-keto-4-methyl-1,4-benzothiazin-6-yl)urea
  • SMR000127969
  • MLS000522702

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens microtubule-associated protein tau Starlite/ChEMBL No references
Homo sapiens survival of motor neuron 2, centromeric Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific methyltransferase 2A Starlite/ChEMBL No references
Photinus pyralis Luciferin 4-monooxygenase Starlite/ChEMBL No references
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Homo sapiens multiple endocrine neoplasia I No references
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references
Homo sapiens transient receptor potential cation channel, subfamily V, member 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni microtubule-associated protein tau Get druggable targets OG5_133504 All targets in OG5_133504
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Plasmodium yoelii peroxisomal-coenzyme a synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative Get druggable targets OG5_130642 All targets in OG5_130642
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum Menin, putative Get druggable targets OG5_133913 All targets in OG5_133913
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium falciparum acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Toxoplasma gondii histone lysine methyltransferase SET1 Get druggable targets OG5_130642 All targets in OG5_130642
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni mixed-lineage leukemia protein mll Get druggable targets OG5_130642 All targets in OG5_130642
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum ko:K04380 microtubule-associated protein tau, putative Get druggable targets OG5_133504 All targets in OG5_133504
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Plasmodium vivax acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania braziliensis 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium berghei acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Echinococcus granulosus microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Onchocerca volvulus Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain fatty-acid CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni hypothetical protein Get druggable targets OG5_133913 All targets in OG5_133913
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium knowlesi acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-coA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Neospora caninum Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a Get druggable targets OG5_130642 All targets in OG5_130642
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 461 aa 22.3 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 577 aa 22.2 %
Trichomonas vaginalis AMP dependent ligase, putative Luciferin 4-monooxygenase   550 aa 445 aa 26.1 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD29 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 529 aa 22.3 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 480 aa 22.5 %
Mycobacterium ulcerans non-ribosomal peptide synthetase Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD21 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 586 aa 24.4 %
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 482 aa 24.3 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 596 aa 21.1 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 545 aa 24.9 %
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 509 aa 22.6 %
Mycobacterium tuberculosis Probable acyl-CoA ligase FadD31 (acyl-CoA synthetase) (acyl-CoA synthase) Luciferin 4-monooxygenase   550 aa 592 aa 20.4 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 504 aa 22.6 %
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 509 aa 21.8 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 517 aa 24.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 505 aa 28.1 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD29 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 617 aa 22.2 %
Leishmania mexicana long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 483 aa 23.8 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 24.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD34 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 537 aa 20.9 %
Cryptosporidium hominis acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 26.1 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 603 aa 22.6 %
Mycobacterium leprae FATTY-ACID-CoA LIGASE FADD26 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 533 aa 22.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Loa Loa (eye worm) AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 489 aa 23.3 %
Babesia bovis long-chain acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 445 aa 21.8 %
Leishmania donovani long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Toxoplasma gondii propionate-CoA ligase Luciferin 4-monooxygenase   550 aa 550 aa 21.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 478 aa 21.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 22.6 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF Luciferin 4-monooxygenase   550 aa 558 aa 20.1 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 527 aa 25.0 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 4, putative Luciferin 4-monooxygenase   550 aa 497 aa 23.7 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 530 aa 23.8 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 480 aa 21.5 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 476 aa 23.5 %
Leishmania braziliensis long-chain-fatty-acid-CoA ligase, putative Luciferin 4-monooxygenase   550 aa 504 aa 25.6 %
Entamoeba histolytica acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 446 aa 22.0 %
Babesia bovis fatty acyl-CoA synthetase family protein Luciferin 4-monooxygenase   550 aa 461 aa 23.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 499 aa 19.2 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 462 aa 23.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 558 aa 20.4 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE Luciferin 4-monooxygenase   550 aa 502 aa 22.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Toxoplasma gondii type I fatty acid synthase, putative Luciferin 4-monooxygenase   550 aa 514 aa 19.8 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 550 aa 20.9 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 581 aa 21.2 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 501 aa 24.4 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 484 aa 26.0 %
Cryptosporidium parvum putative long chain fatty acyl CoA synthetase having a signal peptide Luciferin 4-monooxygenase   550 aa 472 aa 24.8 %
Echinococcus granulosus long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 480 aa 25.2 %
Cryptosporidium parvum acetyl-coenzyme A synthetase Luciferin 4-monooxygenase   550 aa 545 aa 22.8 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD23 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 542 aa 23.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 492 aa 23.6 %
Onchocerca volvulus Matrilysin homolog Luciferin 4-monooxygenase   550 aa 466 aa 24.2 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD32 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase). Also shown to have acyl-ACP ligase activity. Luciferin 4-monooxygenase   550 aa 487 aa 22.4 %
Schistosoma japonicum ko:K08745 solute carrier family 27 (fatty acid transporter), member 1, putative Luciferin 4-monooxygenase   550 aa 501 aa 24.6 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 459 aa 27.0 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 494 aa 23.9 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 601 aa 22.5 %
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase Luciferin 4-monooxygenase   550 aa 536 aa 24.4 %
Cryptosporidium hominis acetyl-CoenzymeA synthetase (acetate--coa ligase) (acyl-activating enzyme) Luciferin 4-monooxygenase   550 aa 549 aa 22.6 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 Luciferin 4-monooxygenase   550 aa 463 aa 21.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 507 aa 20.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 22.9 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 452 aa 26.1 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD32 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 442 aa 23.5 %
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 Luciferin 4-monooxygenase   550 aa 493 aa 22.1 %
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD28 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 484 aa 20.5 %
Leishmania infantum long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD25 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 475 aa 21.1 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Trypanosoma brucei fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD26 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 560 aa 21.4 %
Trypanosoma cruzi fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 495 aa 22.6 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 582 aa 22.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 576 aa 19.8 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 497 aa 19.3 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 497 aa 24.7 %
Mycobacterium ulcerans putative fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 576 aa 20.8 %
Leishmania mexicana acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 559 aa 20.6 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 494 aa 24.3 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 466 aa 21.7 %
Cryptosporidium parvum acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 25.7 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD11 Luciferin 4-monooxygenase   550 aa 498 aa 23.5 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 531 aa 19.0 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 502 aa 24.9 %
Onchocerca volvulus Lysine-specific histone demethylase 1A homolog Luciferin 4-monooxygenase   550 aa 550 aa 22.5 %
Dictyostelium discoideum acetyl-CoA ligase Luciferin 4-monooxygenase   550 aa 549 aa 22.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Neospora caninum Short-chain dehydrogenase/reductase SDR, related Luciferin 4-monooxygenase   550 aa 518 aa 19.1 %
Schistosoma mansoni FAA1 Long-chain-fatty-acid--CoA ligase 1 Luciferin 4-monooxygenase   550 aa 494 aa 26.3 %
Leishmania braziliensis long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 496 aa 22.8 %
Leishmania major long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 23.2 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 443 aa 26.4 %
Candida albicans similar to S. cerevisiae FAA4 (YMR246W) long-chain fatty acid--CoA synthetase Luciferin 4-monooxygenase   550 aa 478 aa 23.4 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 544 aa 21.5 %
Mycobacterium leprae Probable long-chain-fatty-acid-CoA ligase FadD15 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 484 aa 23.3 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 490 aa 23.3 %
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 535 aa 23.2 %
Trypanosoma congolense fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 500 aa 22.4 %
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein Luciferin 4-monooxygenase   550 aa 476 aa 22.5 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 524 aa 24.0 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 466 aa 27.3 %
Echinococcus multilocularis long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 493 aa 20.7 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 476 aa 20.8 %
Neospora caninum acetyl-coenzyme a synthetase, putative Luciferin 4-monooxygenase   550 aa 549 aa 20.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 487 aa 23.8 %
Mycobacterium leprae PROBABLE FATTY-ACID--CoA LIGASE FADD21 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 565 aa 22.8 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 593 aa 22.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 463 aa 23.5 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 526 aa 22.4 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase, FadD11 Luciferin 4-monooxygenase   550 aa 492 aa 24.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 21.7 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.5 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 24.7 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD24 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 526 aa 21.9 %
Theileria parva long-chain fatty acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 507 aa 23.5 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major hypothetical protein, conserved 0.0069 0.032 1
Brugia malayi hypothetical protein 0.0043 0.0192 0.1357
Brugia malayi MH1 domain containing protein 0.001 0.0024 0.0157
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0118 0.3342
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0011 0.0029 0.0012
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0251 0.0234
Brugia malayi MH2 domain containing protein 0.001 0.0024 0.0157
Onchocerca volvulus 0.0069 0.032 1
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0118 0.0828
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 32 0.0069 0.032 0.2267
Echinococcus granulosus smad 0.001 0.0024 0.0007
Loa Loa (eye worm) large conductance calcium-activated potassium channel alpha subunit ai 0.0069 0.032 0.0317
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0019 0.007 0.0053
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0019 0.007 0.0053
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0251 0.0249
Brugia malayi CXXC zinc finger family protein 0.0035 0.0148 0.1044
Onchocerca volvulus 0.0035 0.0148 0.4342
Loa Loa (eye worm) MH2 domain-containing protein 0.001 0.0024 0.0022
Loa Loa (eye worm) hypothetical protein 0.0069 0.032 0.0317
Loa Loa (eye worm) hypothetical protein 0.0069 0.032 0.0317
Trypanosoma cruzi calcium/potassium channel (CAKC), putative 0.0069 0.032 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0276 0.0274
Brugia malayi Smad1 0.001 0.0024 0.0157
Schistosoma mansoni hypothetical protein 0.0041 0.0181 0.0181
Trypanosoma cruzi hypothetical protein, conserved 0.0069 0.032 1
Loa Loa (eye worm) hypothetical protein 0.0069 0.032 0.0317
Trypanosoma cruzi calcium/potassium channel (CAKC), putative 0.0069 0.032 1
Schistosoma mansoni hypothetical protein 0.0019 0.007 0.007
Brugia malayi AMP-binding enzyme family protein 0.0008 0.0017 0.0106
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0017 0.0106
Loa Loa (eye worm) hypothetical protein 0.0069 0.032 0.0317
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.0118 1
Onchocerca volvulus 0.0069 0.032 1
Loa Loa (eye worm) hypothetical protein 0.0069 0.032 0.0317
Schistosoma mansoni twik family of potassium channels-related 0.0069 0.032 0.032
Loa Loa (eye worm) hypothetical protein 0.0019 0.007 0.0068
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 28 0.0069 0.032 0.2267
Brugia malayi hypothetical protein 0.0069 0.032 0.2267
Plasmodium vivax potassium channel, putative 0.0069 0.032 1
Leishmania major potassium channel subunit-like protein 0.0069 0.032 1
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0008 0.0017 0.0189
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 45 0.0069 0.032 0.2267
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0017 0.0189
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0069 0.032 1
Loa Loa (eye worm) hypothetical protein 0.0069 0.032 0.0317
Echinococcus granulosus dnaJ subfamily B 0.0494 0.2443 0.243
Echinococcus granulosus TWiK family of potassium channels protein 7 0.0069 0.032 0.0303
Schistosoma mansoni twik family of potassium channels-related 0.0069 0.032 0.032
Toxoplasma gondii ion channel protein 0.0069 0.032 1
Entamoeba histolytica hypothetical protein 0.0043 0.0192 0.579
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0192 0.0175
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0008 0.0017 0.0189
Schistosoma mansoni survival motor neuron protein 0.0058 0.0266 0.0266
Loa Loa (eye worm) hypothetical protein 0.0069 0.032 0.0317
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0251 0.0251
Loa Loa (eye worm) hypothetical protein 0.0029 0.0118 0.0116
Leishmania major calcium/potassium channel (CAKC), putative 0.0069 0.032 1
Onchocerca volvulus 0.0069 0.032 1
Loa Loa (eye worm) hypothetical protein 0.0069 0.032 0.0317
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 7 0.0069 0.032 0.2267
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0069 0.032 1
Schistosoma mansoni hypothetical protein 0.0043 0.0192 0.0192
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 19. C. elegans unc-58 ortholog 0.0069 0.032 0.2267
Schistosoma mansoni hypothetical protein 0.0494 0.2443 0.2443
Brugia malayi F/Y-rich N-terminus family protein 0.0011 0.0028 0.0184
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0029 0.0118 0.3342
Schistosoma mansoni calcium-activated potassium channel 0.1267 0.6306 0.6306
Plasmodium falciparum potassium channel 0.0069 0.032 1
Schistosoma mansoni cpg binding protein 0.0037 0.0158 0.0158
Loa Loa (eye worm) uncoordinated protein 58 0.0069 0.032 0.0317
Schistosoma mansoni TGF-beta signal transducer Smad2 0.001 0.0024 0.0024
Echinococcus granulosus TGF beta signal transducer SmadC 0.001 0.0024 0.0007
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0118 0.3342
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0019 0.007 0.0053
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0251 0.0234
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0251 0.0234
Loa Loa (eye worm) TWK-28 protein 0.0069 0.032 0.0317
Loa Loa (eye worm) hypothetical protein 0.0069 0.032 0.0317
Echinococcus multilocularis cpg binding protein 0.0037 0.0158 0.0141
Schistosoma mansoni hypothetical protein 0.0058 0.0266 0.0266
Echinococcus granulosus Smad4 0.001 0.0024 0.0007
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0118 0.3342
Toxoplasma gondii ion channel protein 0.0069 0.032 1
Mycobacterium ulcerans transmembrane cation transporter 0.0069 0.032 1
Entamoeba histolytica hypothetical protein 0.0043 0.0192 0.579
Loa Loa (eye worm) hypothetical protein 0.0069 0.032 0.0317
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0029 0.0118 0.3342
Loa Loa (eye worm) hypothetical protein 0.0008 0.0017 0.0015
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0074 0.0343 0.0343
Mycobacterium tuberculosis Possible transmembrane cation transporter 0.0069 0.032 1
Echinococcus multilocularis potassium channel subfamily K 8 0.0069 0.032 0.0303
Brugia malayi AMP-binding enzyme family protein 0.0008 0.0017 0.0106
Plasmodium falciparum potassium channel 0.0069 0.032 1
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.0695 0.0693
Schistosoma mansoni smad 0.001 0.0024 0.0024
Echinococcus granulosus twik family of potassium channels 0.0069 0.032 0.0303
Onchocerca volvulus 0.0058 0.0266 0.8235
Brugia malayi AMP-binding enzyme family protein 0.0008 0.0017 0.0106
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0069 0.032 1
Loa Loa (eye worm) hypothetical protein 0.0069 0.032 0.0317
Loa Loa (eye worm) S-phase kinase-associated protein 1A 0.0069 0.032 0.0317
Schistosoma mansoni hypothetical protein 0.2006 1 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0076 0.2105
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0076 0.2105
Schistosoma mansoni microtubule-associated protein tau 0.0833 0.4139 0.4139
Mycobacterium ulcerans ion transport protein 0.0069 0.032 1
Echinococcus multilocularis potassium channel subfamily K 8 0.0069 0.032 0.0303
Loa Loa (eye worm) hypothetical protein 0.067 0.3325 0.3323
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0251 0.0234
Onchocerca volvulus 0.0029 0.0118 0.3342
Toxoplasma gondii histone lysine methyltransferase SET1 0.0066 0.0303 0.9468
Trypanosoma cruzi calcium-activated potassium channel, putative 0.0069 0.032 1
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 30. 0.0069 0.032 0.2267
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.007 0.0486
Brugia malayi MH2 domain containing protein 0.001 0.0024 0.0157
Loa Loa (eye worm) hypothetical protein 0.0069 0.032 0.0317
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0118 0.0828
Loa Loa (eye worm) hypothetical protein 0.0021 0.0082 0.008
Echinococcus granulosus mixed lineage leukemia protein mll 0.0009 0.0018 0.0001
Loa Loa (eye worm) hypothetical protein 0.0069 0.032 0.0317
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0009 0.0018 0.0018
Loa Loa (eye worm) hypothetical protein 0.006 0.0276 0.0274
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0069 0.032 1
Schistosoma mansoni twik family of potassium channels-related 0.0069 0.032 0.032
Schistosoma mansoni smad1 5 8 and 0.001 0.0024 0.0024
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 13 0.0069 0.032 0.2267
Loa Loa (eye worm) hypothetical protein 0.0069 0.032 0.0317
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 21 0.0069 0.032 0.2267
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0276 0.1955
Loa Loa (eye worm) hypothetical protein 0.0069 0.032 0.0317
Loa Loa (eye worm) hypothetical protein 0.0069 0.032 0.0317
Trichomonas vaginalis antibiotic synthetase, putative 0.0008 0.0017 0.009
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0008 0.0017 0.0015
Loa Loa (eye worm) hypothetical protein 0.0069 0.032 0.0317
Schistosoma mansoni twik family of potassium channels-related 0.0069 0.032 0.032
Echinococcus multilocularis TGF beta signal transducer SmadC 0.001 0.0024 0.0007
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0008 0.0017 0.0189
Echinococcus multilocularis survival motor neuron protein 1 0.0286 0.1402 0.1387
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0251 0.0251
Schistosoma mansoni Smad4 0.001 0.0024 0.0024
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0029 0.0118 0.3342
Giardia lamblia Hypothetical protein 0.0069 0.032 0.5
Schistosoma mansoni acetyl-CoA synthetase 0.0008 0.0017 0.0017
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0251 0.0251
Echinococcus granulosus Two pore potassium channel protein sup 9 0.0069 0.032 0.0303
Echinococcus multilocularis twik family of potassium channels 0.0069 0.032 0.0303
Loa Loa (eye worm) hypothetical protein 0.0069 0.032 0.0317
Onchocerca volvulus 0.0069 0.032 1
Brugia malayi hypothetical protein 0.0286 0.1402 1
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 17 0.0069 0.032 0.2267
Schistosoma mansoni smad1 5 8 and 0.001 0.0024 0.0024
Schistosoma mansoni twik family of potassium channels-related 0.0069 0.032 0.032
Onchocerca volvulus 0.0069 0.032 1
Brugia malayi Twik (KCNK-like) family of potasium channels, alpha subunit 40 0.0069 0.032 0.2267
Loa Loa (eye worm) hypothetical protein 0.0286 0.1402 0.14
Echinococcus multilocularis calcium activated potassium channel variant 0.0069 0.032 0.0303
Brugia malayi MH1 domain containing protein 0.001 0.0024 0.0157
Echinococcus granulosus potassium channel subfamily K 8 0.0069 0.032 0.0303
Echinococcus granulosus calcium activated potassium channel variant 0.0069 0.032 0.0303
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0118 0.3342
Echinococcus granulosus cpg binding protein 0.0037 0.0158 0.0141
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0076 0.2105
Brugia malayi AMP-binding enzyme family protein 0.0008 0.0017 0.0106
Entamoeba histolytica hypothetical protein 0.0043 0.0192 0.579
Schistosoma mansoni hypothetical protein 0.0019 0.007 0.007
Echinococcus multilocularis dnaJ subfamily B 0.0494 0.2443 0.243
Echinococcus multilocularis microtubule associated protein 2 0.0833 0.4139 0.4129
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0019 0.007 0.0053
Echinococcus multilocularis twik family of potassium channels 0.0069 0.032 0.0303
Schistosoma mansoni calcium-activated potassium channel 0.0069 0.032 0.032
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.0118 1
Mycobacterium ulcerans hypothetical protein 0.0029 0.0118 0.3342
Loa Loa (eye worm) hypothetical protein 0.0069 0.032 0.0317
Echinococcus multilocularis small conductance calcium activated potassium 0.2006 1 1
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0008 0.0017 0.0189
Echinococcus granulosus mothers against decapentaplegic 5 0.001 0.0024 0.0007
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0017 0.0189
Loa Loa (eye worm) hypothetical protein 0.0069 0.032 0.0317
Echinococcus granulosus twik family of potassium channels 0.0069 0.032 0.0303
Echinococcus multilocularis Two pore potassium channel protein sup 9 0.0069 0.032 0.0303
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0029 0.0118 0.3342
Schistosoma mansoni hypothetical protein 0.0069 0.032 0.032
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0021 0.0082 0.2295
Loa Loa (eye worm) hypothetical protein 0.0558 0.2765 0.2763
Loa Loa (eye worm) hypothetical protein 0.0069 0.032 0.0317
Schistosoma mansoni twik family of potassium channels-related 0.0069 0.032 0.032
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0276 0.1955
Trypanosoma cruzi ion transport protein, putative 0.0069 0.032 1
Brugia malayi hypothetical protein 0.0069 0.032 0.2267
Trypanosoma brucei calcium-activated potassium channel, putative 0.0069 0.032 1
Loa Loa (eye worm) hypothetical protein 0.0069 0.032 0.0317
Loa Loa (eye worm) oxidoreductase 0.0008 0.0017 0.0015
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.0118 0.3468
Loa Loa (eye worm) hypothetical protein 0.2006 1 1
Schistosoma mansoni calcium-activated potassium channel 0.0069 0.032 0.032
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0069 0.032 1
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0008 0.0017 0.0106
Loa Loa (eye worm) hypothetical protein 0.0008 0.0017 0.0015
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0018 0.0001
Loa Loa (eye worm) hypothetical protein 0.0069 0.032 0.0317
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0008 0.0017 0.0189
Entamoeba histolytica calcium-gated potassium channel protein, putative 0.0069 0.032 1
Brugia malayi Latrophilin receptor protein 2 0.0019 0.007 0.0486
Loa Loa (eye worm) hypothetical protein 0.0021 0.0082 0.008
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0118 0.3342
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0076 0.2105
Trichomonas vaginalis antibiotic synthetase, putative 0.0008 0.0017 0.009
Echinococcus multilocularis potassium channel subfamily K 0.0069 0.032 0.0303
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 12 0.0069 0.032 0.2267
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 39B 0.0069 0.032 0.2267
Loa Loa (eye worm) hypothetical protein 0.0069 0.032 0.0317
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0018 0.0001
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0009 0.0018 0.0001
Echinococcus granulosus microtubule associated protein 2 0.0833 0.4139 0.4129
Loa Loa (eye worm) hypothetical protein 0.0069 0.032 0.0317
Trypanosoma cruzi ion transport protein, putative 0.0069 0.032 1
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0021 0.0082 0.5
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0008 0.0017 0.0015
Onchocerca volvulus 0.0069 0.032 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0118 0.3342
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0017 0.0189
Loa Loa (eye worm) hypothetical protein 0.0029 0.0118 0.0116
Loa Loa (eye worm) histone methyltransferase 0.0011 0.0029 0.0026
Loa Loa (eye worm) hypothetical protein 0.0021 0.0082 0.008
Loa Loa (eye worm) hypothetical protein 0.0069 0.032 0.0317
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0118 0.3342
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 38. C. elegans sup-9 ortholog 0.0069 0.032 0.2267
Echinococcus multilocularis GPCR, family 2 0.0019 0.007 0.0053
Loa Loa (eye worm) Smad1 0.001 0.0024 0.0022
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.007 0.0068
Echinococcus multilocularis TWiK family of potassium channels protein 7 0.0069 0.032 0.0303
Onchocerca volvulus 0.0069 0.032 1
Loa Loa (eye worm) potassium voltage-gated channel subfamily Q member 5 0.0069 0.032 0.0317
Plasmodium vivax potassium channel, putative 0.0069 0.032 1
Loa Loa (eye worm) MH1 domain-containing protein 0.001 0.0024 0.0022
Schistosoma mansoni smad1 5 8 and 0.001 0.0024 0.0024
Trypanosoma brucei calcium/potassium channel (CAKC), putative 0.0069 0.032 1
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0017 0.0189
Loa Loa (eye worm) hypothetical protein 0.0021 0.0082 0.008
Loa Loa (eye worm) hypothetical protein 0.0069 0.032 0.0317
Loa Loa (eye worm) hypothetical protein 0.0069 0.032 0.0317
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 24 0.0069 0.032 0.2267
Loa Loa (eye worm) hypothetical protein 0.0069 0.032 0.0317
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0118 0.3342
Loa Loa (eye worm) hypothetical protein 0.0029 0.0118 0.0116
Echinococcus granulosus potassium channel subfamily K 8 0.0069 0.032 0.0303
Schistosoma mansoni calcium-activated potassium channel 0.2006 1 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0251 0.1778
Loa Loa (eye worm) hypothetical protein 0.0021 0.0082 0.008
Schistosoma mansoni twik family of potassium channels-related 0.0069 0.032 0.032
Onchocerca volvulus 0.0069 0.032 1
Brugia malayi MH2 domain containing protein 0.0144 0.0695 0.4953
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 39A 0.0069 0.032 0.2267
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0008 0.0017 0.0189
Loa Loa (eye worm) hypothetical protein 0.0069 0.032 0.0317
Echinococcus granulosus GPCR family 2 0.0019 0.007 0.0053
Plasmodium falciparum acyl-CoA synthetase 0.0021 0.0082 0.2146
Loa Loa (eye worm) CXXC zinc finger family protein 0.0035 0.0148 0.0146
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0008 0.0017 0.0189
Loa Loa (eye worm) hypothetical protein 0.0069 0.032 0.0317
Schistosoma mansoni cpg binding protein 0.0035 0.0148 0.0148
Entamoeba histolytica acyl-coA synthetase, putative 0.0029 0.0118 0.3342
Entamoeba histolytica hypothetical protein 0.0043 0.0192 0.579
Loa Loa (eye worm) hypothetical protein 0.0069 0.032 0.0317
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 35 0.0069 0.032 0.2267
Trypanosoma cruzi calcium-activated potassium channel, putative 0.0069 0.032 1
Loa Loa (eye worm) hypothetical protein 0.0709 0.3516 0.3515
Echinococcus granulosus survival motor neuron protein 1 0.0286 0.1402 0.1387
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0181 0.1275
Leishmania major hypothetical protein, conserved 0.0069 0.032 1
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0029 0.0118 0.3468
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.0695 0.0693
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0192 0.0175
Echinococcus granulosus potassium channel subfamily K 0.0069 0.032 0.0303
Plasmodium vivax acyl-CoA synthetase, putative 0.0021 0.0082 0.2146
Echinococcus multilocularis smad 0.001 0.0024 0.0007
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0118 0.0828
Schistosoma mansoni hypothetical protein 0.0019 0.007 0.007
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0021 0.0082 0.2146
Echinococcus multilocularis mothers against decapentaplegic 5 0.001 0.0024 0.0007
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0058 0.0266 0.1885
Trypanosoma cruzi hypothetical protein, conserved 0.0069 0.032 1
Schistosoma mansoni twik family of potassium channels-related 0.0069 0.032 0.032
Echinococcus multilocularis Smad4 0.001 0.0024 0.0007
Loa Loa (eye worm) TWK-7 protein 0.0069 0.032 0.0317
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 5 0.0069 0.032 0.2267
Loa Loa (eye worm) hypothetical protein 0.0069 0.032 0.0317
Schistosoma mansoni hypothetical protein 0.0019 0.007 0.007
Leishmania major ion transport protein-like protein 0.0069 0.032 1
Schistosoma mansoni cpg binding protein 0.0037 0.0158 0.0158
Loa Loa (eye worm) hypothetical protein 0.0041 0.0181 0.0179
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0192 0.0192
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0011 0.0029 0.0012

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) = 35.688 uM PUBCHEM_BIOASSAY: Counterscreen for agonists of heterodimerization of the mu 1 (OPRM1) and delta 1 (OPRD1) opioid receptors: Luminescence-based cell-based high throughput dose response assay to identify agonists of OPRD1 homodimerization. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504326, AID504355, AID504692, AID504904, AID504905] ChEMBL. No reference
EC50 (functional) = 36.748 uM PubChem BioAssay. Counterscreen for agonists of heterodimerization of the mu 1 (OPRM1) and delta 1 (OPRD1) opioid receptors: Luminescence-based cell-based high throughput dose response assay to identify agonists of OPRM1 homodimerization. (Class of assay: confirmatory) ChEMBL. No reference
EC50 (functional) > 92.48 uM PUBCHEM_BIOASSAY: Counterscreen for agonists of OPRM1-OPRD1 heterodimerization: luminescence-based cell-based high throughput dose response assay to identify agonists of 5-hydroxytryptamine (serotonin) 5A receptor (HTR5A). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504326, AID504355, AID504692, AID504904, AID504905] ChEMBL. No reference
Potency (functional) 0.1153 uM PUBCHEM_BIOASSAY: qHTS Assay for Compounds that Act as Potentiators of the Vanilloid Receptor 1: Hit Validation. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 0.2581 uM PUBCHEM_BIOASSAY: qHTS Assay for Compounds that Act as Agonists of the Vanilloid Receptor 1: Hit Validation. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 3.5481 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.9955 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 14.1254 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 14.1254 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 14.7157 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 16.3601 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) = 17.7828 um PUBCHEM_BIOASSAY: Counterscreen qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. This assay monitors tau fibrillation by fluorescence polarization (FP) of Alexa 594-labeled K18 P301L, which does not fibrillize readily but incorporates into growing filaments of unlabeled tau. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 21.1923 uM PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 22.3872 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 23.1093 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Aggregate Formation (GFP). (Class of assay: confirmatory) [Related pubchem assays: 1482, 1471 ] ChEMBL. No reference
Potency (functional) 35.4813 uM PubChem BioAssay. qHTS for Antagonists of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (binding) = 44.6684 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference
Potency (functional) 63.0957 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: Inhibitors of the vitamin D receptor (VDR): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504855] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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