Detailed information for compound 88504

Basic information

Technical information
  • TDR Targets ID: 88504
  • Name: 2-(2,6-difluorophenyl)-1-[(2,6-difluorophenyl )methyl]-N-methylbenzimidazol-4-amine
  • MW: 385.358 | Formula: C21H15F4N3
  • H donors: 1 H acceptors: 1 LogP: 5.08 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CNc1cccc2c1nc(n2Cc1c(F)cccc1F)c1c(F)cccc1F
  • InChi: 1S/C21H15F4N3/c1-26-17-9-4-10-18-20(17)27-21(19-15(24)7-3-8-16(19)25)28(18)11-12-13(22)5-2-6-14(12)23/h2-10,26H,11H2,1H3
  • InChiKey: UATDPISGFUQRMU-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-(2,6-difluorophenyl)-1-[(2,6-difluorophenyl)methyl]-N-methyl-benzimidazol-4-amine
  • 2-(2,6-difluorophenyl)-1-[(2,6-difluorophenyl)methyl]-N-methyl-4-benzimidazolamine
  • [1-(2,6-difluorobenzyl)-2-(2,6-difluorophenyl)benzimidazol-4-yl]-methyl-amine
  • AIDS-122012
  • AIDS122012
  • 1H-Benzimidazol-4-amine, 2-(2,6-difluorophenyl)-1-[(2,6-difluorophenyl)methyl]-N-methyl-

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 reverse transcriptase Starlite/ChEMBL References
Human immunodeficiency virus 1 Reverse transcriptase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma brucei RNA helicase, putative Get druggable targets OG5_139608 All targets in OG5_139608
Trypanosoma congolense RNA helicase, putative Get druggable targets OG5_139608 All targets in OG5_139608
Schistosoma mansoni hypothetical protein Get druggable targets OG5_139608 All targets in OG5_139608
Plasmodium yoelii integrase-related Get druggable targets OG5_139608 All targets in OG5_139608
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma congolense Retroviral aspartyl protease/Reverse transcriptase (RNA-dependent DNA polymerase)/RNase H, putative Reverse transcriptase   259 aa 237 aa 29.1 %
Dictyostelium discoideum hypothetical protein Reverse transcriptase   259 aa 245 aa 25.7 %
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) Reverse transcriptase   259 aa 227 aa 26.4 %
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) Reverse transcriptase   259 aa 227 aa 26.4 %
Dictyostelium discoideum hypothetical protein Reverse transcriptase   259 aa 222 aa 22.5 %
Candida albicans polyprotein of retrotransposon Tca8 Reverse transcriptase   259 aa 238 aa 26.5 %
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) Reverse transcriptase   259 aa 208 aa 26.4 %
Candida albicans ReverseTranscriptase similar to fruit fly Tom element Reverse transcriptase   259 aa 244 aa 27.9 %
Candida albicans hypothetical protein Reverse transcriptase   259 aa 223 aa 29.1 %
Dictyostelium discoideum hypothetical protein Reverse transcriptase   259 aa 226 aa 24.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0086 0.0184 0.993
Trichomonas vaginalis PIKK family atypical protein kinase 0.0086 0.0184 0.1795
Trichomonas vaginalis conserved hypothetical protein 0.0282 0.0638 0.6225
Schistosoma mansoni ferritin 0.0009 0.0005 0.0022
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0065 0.1276
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0011 0.0009 0.0047
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0448 0.1025 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0086 0.0184 0.1035
Schistosoma mansoni hypothetical protein 0.0033 0.006 0.0346
Wolbachia endosymbiont of Brugia malayi ribonuclease HI 0.0027 0.0046 0.2264
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0448 0.1025 0.5791
Onchocerca volvulus 0.001 0.0006 0.0111
Echinococcus granulosus importin subunit beta 1 0.0028 0.0049 0.0048
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0065 0.2429
Toxoplasma gondii aldehyde dehydrogenase 0.0121 0.0266 0.2587
Schistosoma mansoni apoferritin-2 0.0009 0.0005 0.0022
Loa Loa (eye worm) hypothetical protein 0.0025 0.0043 0.0235
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0037 0.0358
Echinococcus multilocularis GPCR, family 2 0.0015 0.0019 0.0018
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0025 0.0043 0.2259
Giardia lamblia Ribonuclease H 0.0027 0.0046 0.0149
Loa Loa (eye worm) steroid hormone receptor 0.0011 0.0009 0.0045
Schistosoma mansoni phosphoglucomutase 0.0027 0.0046 0.0261
Giardia lamblia Kinase, PLK 0.0105 0.0227 0.1973
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0086 0.0184 0.1795
Loa Loa (eye worm) hypothetical protein 0.0768 0.1769 1
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0121 0.0266 0.5252
Trichomonas vaginalis PIKK family atypical protein kinase 0.0448 0.1025 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0065 0.0364
Echinococcus granulosus snurportin 1 0.03 0.0682 0.0681
Brugia malayi beta-lactamase family protein 0.0035 0.0065 0.0364
Schistosoma mansoni steroid hormone receptor ad4bp 0.0011 0.0009 0.0047
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.001 0.0006 0.0027
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0043 0.0114
Mycobacterium ulcerans bacterioferritin BfrB 0.0009 0.0005 0.0142
Echinococcus granulosus ribonuclease H1 0.0027 0.0046 0.0045
Echinococcus granulosus peptidase Clp S14 family 0.0057 0.0116 0.0115
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0448 0.1025 0.1024
Trichomonas vaginalis PIKK family atypical protein kinase 0.0448 0.1025 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0253 0.0571 0.557
Loa Loa (eye worm) hypothetical protein 0.0193 0.0432 0.244
Leishmania major phosphatidylinositol kinase, putative 0.0086 0.0184 0.05
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0086 0.0184 0.1795
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0086 0.0184 0.0529
Loa Loa (eye worm) hypothetical protein 0.0025 0.0043 0.0235
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0015 0.0019 0.0018
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0068 0.0142 0.08
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0253 0.0571 0.1646
Trichomonas vaginalis PIKK family atypical protein kinase 0.0282 0.0638 0.6225
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.003 0.0053 0.283
Trichomonas vaginalis CAMK family protein kinase 0.0105 0.0227 0.2214
Giardia lamblia Phosphatidylinositol 4-kinase 0.0086 0.0184 0.1541
Loa Loa (eye worm) phosphatidylinositol 3 0.0448 0.1025 0.5791
Trichomonas vaginalis PIKK family atypical protein kinase 0.0253 0.0571 0.557
Echinococcus multilocularis ecdysone induced protein 78C 0.0011 0.0009 0.0008
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0374 0.0853 0.8318
Leishmania major phosphatidylinositol 3-kinase, putative 0.0086 0.0184 0.05
Trichomonas vaginalis PIKK family atypical protein kinase 0.0448 0.1025 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0011 0.0009 0.0045
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0009 0.0005 0.0075
Brugia malayi beta-lactamase 0.0035 0.0065 0.0364
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0086 0.0184 0.0183
Echinococcus granulosus Pleckstrin G protein interacting region 0.001 0.0006 0.0005
Loa Loa (eye worm) hypothetical protein 0.0282 0.0638 0.3603
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0008 0.0002 0.0003
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.003 0.0053 0.283
Trichomonas vaginalis antibiotic synthetase, putative 0.0007 0.0001 0.001
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0011 0.0009 0.0045
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0086 0.0184 0.1787
Schistosoma mansoni hypothetical protein 0.0015 0.0019 0.0106
Echinococcus granulosus regulator of G protein signaling 7 0.001 0.0006 0.0005
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0065 0.0186
Plasmodium vivax acyl-CoA synthetase, putative 0.0019 0.0028 0.1451
Leishmania major phosphatidylinositol 4-kinase, putative 0.0086 0.0184 0.05
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0057 0.0116 0.2277
Mycobacterium ulcerans aldehyde dehydrogenase 0.0121 0.0266 1
Brugia malayi nuclear receptor NHR-88 0.0011 0.0009 0.0045
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0448 0.1025 0.2957
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0087 0.0185 1
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0011 0.0009 0.0008
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.03 0.0682 0.385
Trichomonas vaginalis CAMK family protein kinase 0.0052 0.0104 0.1016
Brugia malayi serine/threonine-protein kinase plk-2 0.0105 0.0227 0.1278
Schistosoma mansoni hypothetical protein 0.0015 0.0019 0.0106
Echinococcus multilocularis cpg binding protein 0.0033 0.006 0.0059
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0448 0.1025 0.1024
Loa Loa (eye worm) hypothetical protein 0.001 0.0006 0.0027
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0009 0.0008
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0086 0.0184 0.0183
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0043 0.1572
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0087 0.0185 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0031 0.0086
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0065 0.0376
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0086 0.0184 0.1787
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0087 0.0185 0.18
Leishmania major phosphatidylinositol kinase related protein, putative 0.0208 0.0466 0.1269
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0065 0.0064
Onchocerca volvulus Serine\/threonine kinase homolog 0.0105 0.0227 0.5236
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0195 0.0438 0.0437
Brugia malayi Latrophilin receptor protein 2 0.0015 0.0019 0.0102
Brugia malayi Muscleblind-like protein 0.0768 0.1769 1
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0009 0.0005 0.0075
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0048 0.0096 0.0535
Schistosoma mansoni RAR-like nuclear receptor 0.0011 0.0009 0.0047
Echinococcus granulosus serine protein kinase ATM 0.0374 0.0853 0.0852
Mycobacterium ulcerans hypothetical protein 0.0025 0.0043 0.1572
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0011 0.0009 0.0008
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0065 0.0637
Toxoplasma gondii ribonuclease HI protein 0.0027 0.0046 0.0436
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0448 0.1025 0.2796
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0086 0.0184 0.1787
Loa Loa (eye worm) hypothetical protein 0.0035 0.0065 0.0364
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0086 0.0184 0.1069
Brugia malayi Importin beta-1 subunit 0.0028 0.0049 0.0272
Mycobacterium tuberculosis Conserved protein 0.0035 0.0065 0.1276
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.0009 0.0047
Toxoplasma gondii hypothetical protein 0.001 0.0006 0.0047
Schistosoma mansoni transcription factor LCR-F1 0.0109 0.0238 0.1383
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0086 0.0184 0.1069
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0031 0.0301
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0025 0.0043 0.1572
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.002 0.0031 0.1127
Entamoeba histolytica hypothetical protein 0.0086 0.0184 0.1787
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0253 0.0571 0.3223
Toxoplasma gondii hypothetical protein 0.003 0.0053 0.0509
Onchocerca volvulus 0.0086 0.0184 0.4242
Trichomonas vaginalis PIKK family atypical protein kinase 0.0253 0.0571 0.557
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0011 0.0009 0.0045
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0086 0.0184 0.0183
Trichomonas vaginalis PIKK family atypical protein kinase 0.0374 0.0853 0.832
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0086 0.0184 0.1069
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0006 0.0005
Trichomonas vaginalis PIKK family atypical protein kinase 0.0448 0.1025 1
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0087 0.0185 0.18
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.0043 0.0407
Leishmania major hypothetical protein, conserved 0.1584 0.3664 1
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0086 0.0184 0.1069
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0086 0.0184 0.0529
Schistosoma mansoni ferritin 0.0009 0.0005 0.0022
Trypanosoma cruzi polo-like protein kinase, putative 0.0105 0.0227 0.0653
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0049 0.047
Loa Loa (eye worm) hypothetical protein 0.0011 0.0009 0.0045
Brugia malayi hypothetical protein 0.0109 0.0238 0.1339
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0011 0.0009 0.0008
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0448 0.1025 0.2796
Echinococcus granulosus ferritin 0.0009 0.0005 0.0004
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0087 0.0185 1
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0086 0.0184 0.1787
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0025 0.0043 0.1572
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0065 0.0637
Loa Loa (eye worm) hypothetical protein 0.0087 0.0185 0.1042
Loa Loa (eye worm) TAR-binding protein 0.0068 0.0142 0.08
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.0031 0.0291
Brugia malayi RNA binding protein 0.0068 0.0142 0.08
Brugia malayi RNA recognition motif domain containing protein 0.0068 0.0142 0.08
Loa Loa (eye worm) phosphatidylinositol 3 0.0086 0.0184 0.1035
Leishmania major hypothetical protein, conserved 0.0035 0.0065 0.0176
Trypanosoma cruzi ribonuclease H1, putative 0.0027 0.0046 0.0129
Trichomonas vaginalis PIKK family atypical protein kinase 0.0448 0.1025 1
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0086 0.0184 0.0529
Onchocerca volvulus Bile acid receptor homolog 0.0011 0.0009 0.0186
Trichomonas vaginalis PIKK family atypical protein kinase 0.0448 0.1025 1
Trichomonas vaginalis CAMK family protein kinase 0.0105 0.0227 0.2214
Echinococcus multilocularis FTZ F1 alpha 0.0011 0.0009 0.0008
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.002 0.0031 0.0081
Treponema pallidum ribonuclease H (rnhA) 0.0027 0.0046 0.2264
Trypanosoma brucei ingi protein (ORF1) 0.0033 0.006 0.0573
Loa Loa (eye worm) hypothetical protein 0.0035 0.0065 0.0364
Trypanosoma cruzi hypothetical protein, conserved 0.1498 0.3464 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0006 0.0027
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0086 0.0184 0.0529
Schistosoma mansoni dep domain containing protein 0.001 0.0006 0.0028
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0448 0.1025 0.5979
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0031 0.003
Plasmodium vivax hypothetical protein, conserved 0.0086 0.0184 0.993
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0086 0.0184 0.993
Trichomonas vaginalis PIKK family atypical protein kinase 0.0448 0.1025 1
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0025 0.0043 0.2259
Loa Loa (eye worm) histone methyltransferase 0.001 0.0006 0.0028
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0086 0.0184 0.1787
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0448 0.1025 0.1024
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0086 0.0184 0.1035
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0086 0.0184 0.1795
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0374 0.0853 0.246
Toxoplasma gondii ABC1 family protein 0.0035 0.0065 0.0628
Trichomonas vaginalis CAMK family protein kinase 0.0105 0.0227 0.2214
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0193 0.0432 1
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0121 0.0266 0.0265
Schistosoma mansoni hypothetical protein 0.0376 0.0857 0.4997
Trichomonas vaginalis CAMK family protein kinase 0.0105 0.0227 0.2214
Brugia malayi steroid hormone receptor 0.0011 0.0009 0.0045
Entamoeba histolytica hypothetical protein 0.0109 0.0238 0.2313
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0086 0.0184 0.1541
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0086 0.0184 0.1035
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0086 0.0184 0.0183
Echinococcus granulosus FTZ F1 alpha 0.0011 0.0009 0.0008
Echinococcus multilocularis snurportin 1 0.03 0.0682 0.0681
Toxoplasma gondii FATC domain-containing protein 0.0374 0.0853 0.8318
Loa Loa (eye worm) hypothetical protein 0.0035 0.0065 0.0364
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0009 0.0008
Trichomonas vaginalis PIKK family atypical protein kinase 0.0448 0.1025 1
Entamoeba histolytica hypothetical protein 0.0109 0.0238 0.2313
Loa Loa (eye worm) hypothetical protein 0.0011 0.0009 0.0045
Onchocerca volvulus 0.0086 0.0184 0.4242
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0086 0.0184 0.0183
Brugia malayi N-terminal motif family protein 0.0193 0.0432 0.244
Trichomonas vaginalis conserved hypothetical protein 0.0167 0.0371 0.3616
Schistosoma mansoni ferritin light chain 0.0009 0.0005 0.0022
Schistosoma mansoni importin beta-1 0.0028 0.0049 0.0281
Entamoeba histolytica hypothetical protein 0.0023 0.0037 0.0349
Entamoeba histolytica hypothetical protein 0.0086 0.0184 0.1787
Trichomonas vaginalis esterase, putative 0.0035 0.0065 0.0637
Schistosoma mansoni dishevelled 0.001 0.0006 0.0028
Trichomonas vaginalis PIKK family atypical protein kinase 0.0448 0.1025 1
Onchocerca volvulus Protein ultraspiracle homolog 0.0011 0.0009 0.0186
Trichomonas vaginalis ribonuclease H1, putative 0.0027 0.0046 0.0445
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0086 0.0184 0.0183
Trichomonas vaginalis PIKK family atypical protein kinase 0.0448 0.1025 1
Mycobacterium leprae PROBABLE BACTERIOFERRITIN BFRA 0.0009 0.0005 0.0205
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0011 0.0009 0.0045
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0448 0.1025 1
Trichomonas vaginalis conserved hypothetical protein 0.0195 0.0438 0.427
Entamoeba histolytica hypothetical protein 0.0109 0.0238 0.2313
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0015 0.0019 0.0018
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0448 0.1025 0.2796
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0448 0.1025 0.2796
Loa Loa (eye worm) hypothetical protein 0.0011 0.0009 0.0045
Loa Loa (eye worm) hypothetical protein 0.0015 0.0019 0.0102
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0011 0.0009 0.0045
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0031 0.1619
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0006 0.0005
Schistosoma mansoni serine/threonine protein kinase 0.0105 0.0227 0.1319
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0448 0.1025 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0028 0.0151
Schistosoma mansoni hypothetical protein 0.0109 0.0238 0.1383
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0015 0.0019 0.0102
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0105 0.0227 0.0226
Echinococcus granulosus cpg binding protein 0.0033 0.006 0.0059
Schistosoma mansoni peptidase Clp (S14 family) 0.0087 0.0185 0.1076
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0011 0.0009 0.0008
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0448 0.1025 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0086 0.0184 0.1795
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0086 0.0184 0.0529
Echinococcus multilocularis regulator of G protein signaling 7 0.001 0.0006 0.0005
Trichomonas vaginalis PIKK family atypical protein kinase 0.0448 0.1025 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0009 0.0045
Loa Loa (eye worm) hypothetical protein 0.0028 0.0049 0.0272
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0086 0.0184 0.1035
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0049 0.047
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0086 0.0184 0.1795
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0086 0.0184 0.1795
Loa Loa (eye worm) hypothetical protein 0.0019 0.0028 0.0151
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0086 0.0184 0.0529
Trichomonas vaginalis CAMK family protein kinase 0.0052 0.0104 0.1016
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0086 0.0184 0.0183
Echinococcus multilocularis microtubule associated protein 2 0.0745 0.1714 0.1713
Echinococcus granulosus segment polarity protein dishevelled 0.001 0.0006 0.0005
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0037 0.0103
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0087 0.0185 0.6959
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0011 0.0009 0.0045
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0253 0.0571 0.057
Echinococcus granulosus dnaJ subfamily B 0.0441 0.1009 0.1008
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0011 0.0009 0.0045
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0057 0.0116 0.2277
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0086 0.0184 0.993
Leishmania major phosphatidylinositol 3-kinase, putative 0.0448 0.1025 0.2796
Loa Loa (eye worm) hypothetical protein 0.0288 0.0652 0.3684
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0011 0.0009 0.0045
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0086 0.0184 0.1795
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0448 0.1025 0.5791
Trichomonas vaginalis PIKK family atypical protein kinase 0.0448 0.1025 1
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0086 0.0184 0.1787
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.0043 0.0407
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0065 0.0637
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0065 0.0628
Trichomonas vaginalis antibiotic synthetase, putative 0.0007 0.0001 0.001
Mycobacterium ulcerans aldehyde dehydrogenase 0.0121 0.0266 1
Schistosoma mansoni hypothetical protein 0.03 0.0682 0.3974
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0086 0.0184 0.1787
Loa Loa (eye worm) hypothetical protein 0.0195 0.0438 0.247
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0086 0.0184 0.993
Schistosoma mansoni z-protein (S1r protein) 0.001 0.0006 0.0028
Schistosoma mansoni hypothetical protein 0.0195 0.0438 0.255
Entamoeba histolytica hypothetical protein 0.0374 0.0853 0.8318
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0086 0.0184 0.1787
Brugia malayi DIX domain containing protein 0.001 0.0006 0.0027
Giardia lamblia GTOR 0.0448 0.1025 1
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0057 0.0116 0.6231
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0043 0.0235
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0087 0.0185 0.0184
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0025 0.0482
Schistosoma mansoni kinase 0.0053 0.0107 0.0621
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0008 0.0002 0.0001
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0086 0.0184 0.0529
Echinococcus multilocularis segment polarity protein dishevelled 0.001 0.0006 0.0005
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0142 0.0826
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0011 0.0009 0.0008
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0006 0.0026
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0282 0.0638 0.6221
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0065 0.2429
Plasmodium vivax importin-beta 2, putative 0.0028 0.0049 0.2609
Echinococcus multilocularis Pleckstrin G protein, interacting region 0.001 0.0006 0.0005
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0065 0.1276
Echinococcus multilocularis segment polarity protein dishevelled 0.001 0.0006 0.0005
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.003 0.0053 0.268
Brugia malayi follicle stimulating hormone receptor 0.0237 0.0535 0.3019
Entamoeba histolytica acyl-coA synthetase, putative 0.0025 0.0043 0.0407
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0025 0.0043 0.0826
Loa Loa (eye worm) hypothetical protein 0.0011 0.0009 0.0045
Loa Loa (eye worm) hypothetical protein 0.0011 0.0009 0.0045
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0019 0.0028 0.1009
Entamoeba histolytica serine/threonine protein kinase, putative 0.0105 0.0227 0.2206
Schistosoma mansoni coup transcription factor 0.0011 0.0009 0.0047
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0237 0.0535 0.3019
Schistosoma mansoni fkbp-rapamycin associated protein 0.0253 0.0571 0.3328
Trichomonas vaginalis PIKK family atypical protein kinase 0.0448 0.1025 1
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0009 0.0045
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0086 0.0184 0.1035
Schistosoma mansoni fyve finger-containing phosphoinositide kinase fyv1 0.001 0.0006 0.0028
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0031 0.003
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0086 0.0184 0.1787
Loa Loa (eye worm) hypothetical protein 0.0086 0.0184 0.1035
Mycobacterium ulcerans hypothetical protein 0.0035 0.0065 0.2429
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0142 0.0826
Schistosoma mansoni hypothetical protein 0.0376 0.0857 0.4997
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0086 0.0184 0.1069
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0086 0.0184 0.1787
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0065 0.1276
Loa Loa (eye worm) CXXC zinc finger family protein 0.0031 0.0056 0.0309
Trichomonas vaginalis PIKK family atypical protein kinase 0.0253 0.0571 0.557
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0065 0.0186
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0105 0.0227 0.0226
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0011 0.0009 0.0008
Trypanosoma cruzi polo-like protein kinase, putative 0.0105 0.0227 0.0653
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0009 0.0045
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0448 0.1025 0.2957
Trichomonas vaginalis ferritin, putative 0.0009 0.0005 0.0046
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0109 0.0238 0.0237
Trichomonas vaginalis PIKK family atypical protein kinase 0.0086 0.0184 0.1795
Loa Loa (eye worm) beta-lactamase 0.0035 0.0065 0.0364
Schistosoma mansoni phosphoglucomutase 0.0027 0.0046 0.0261
Mycobacterium ulcerans aldehyde dehydrogenase 0.0121 0.0266 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0025 0.0482
Brugia malayi ecdysteroid receptor 0.0011 0.0009 0.0045
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0086 0.0184 0.1795
Trypanosoma brucei ingi protein (ORF1) 0.0033 0.006 0.0573
Trypanosoma cruzi target of rapamycin kinase 3 0.0448 0.1025 0.2957
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0105 0.0227 0.1278
Trichomonas vaginalis PIKK family atypical protein kinase 0.0253 0.0571 0.557
Trichomonas vaginalis PIKK family atypical protein kinase 0.0448 0.1025 1
Toxoplasma gondii target of rapamycin (TOR), putative 0.0448 0.1025 1
Schistosoma mansoni hypothetical protein 0.0441 0.1009 0.5886
Onchocerca volvulus 0.0035 0.0065 0.1491
Trichomonas vaginalis PIKK family atypical protein kinase 0.0448 0.1025 1
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0086 0.0184 0.1541
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0066 0.0136 0.0791
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0086 0.0184 0.1787
Echinococcus multilocularis serine protein kinase ATM 0.0374 0.0853 0.0852
Trichomonas vaginalis PIKK family atypical protein kinase 0.0253 0.0571 0.557
Leishmania major hypothetical protein, unknown function 0.0086 0.0184 0.05
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0043 0.0235
Brugia malayi Probable ClpP-like protease 0.0087 0.0185 0.1042
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0031 0.1619
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0065 0.0376
Schistosoma mansoni cpg binding protein 0.0033 0.006 0.0343
Schistosoma mansoni cpg binding protein 0.0033 0.006 0.0343
Trichomonas vaginalis PIKK family atypical protein kinase 0.0448 0.1025 1
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0282 0.0638 0.6221
Plasmodium vivax hypothetical protein 0.0086 0.0184 0.993
Entamoeba histolytica protein kinase rad3, putative 0.0253 0.0571 0.5566
Echinococcus multilocularis thyroid hormone receptor alpha 0.0011 0.0009 0.0008
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0121 0.0266 0.0723
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0086 0.0184 0.0183
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0087 0.0185 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0448 0.1025 1
Schistosoma mansoni nuclear hormone receptor 0.0011 0.0009 0.0047
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0011 0.0009 0.0047
Echinococcus multilocularis ribonuclease H1 0.0027 0.0046 0.0045
Loa Loa (eye worm) phosphatidylinositol kinase 0.0086 0.0184 0.1035
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0011 0.0009 0.0045
Trichomonas vaginalis PIKK family atypical protein kinase 0.0448 0.1025 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0048 0.0096 0.0535
Brugia malayi CXXC zinc finger family protein 0.0031 0.0056 0.0309
Onchocerca volvulus 0.0011 0.0009 0.0186
Loa Loa (eye worm) latrophilin receptor protein 2 0.0015 0.0019 0.0102
Trichomonas vaginalis PIKK family atypical protein kinase 0.0448 0.1025 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0086 0.0184 0.1035
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0086 0.0184 0.1787
Loa Loa (eye worm) phosphatidylinositol 3 0.0086 0.0184 0.1035
Plasmodium falciparum acyl-CoA synthetase 0.0019 0.0028 0.1451
Trichomonas vaginalis CAMK family protein kinase 0.0105 0.0227 0.2214
Brugia malayi FAT domain containing protein 0.0195 0.0438 0.247
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0086 0.0184 0.0183
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.006 0.0335
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0142 0.0826
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0087 0.0185 1
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0086 0.0184 0.993
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0448 0.1025 0.5979
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0374 0.0853 0.4817
Echinococcus granulosus segment polarity protein dishevelled 0.001 0.0006 0.0005
Echinococcus granulosus muscleblind protein 0.0768 0.1769 0.1768
Trypanosoma brucei hypothetical protein, conserved 0.0033 0.006 0.0573
Echinococcus granulosus geminin 0.0376 0.0857 0.0856
Echinococcus granulosus regulator of G protein signaling 7 0.001 0.0006 0.0005
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.002 0.0031 0.1444
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0121 0.0266 0.0265
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0448 0.1025 1
Mycobacterium tuberculosis Conserved protein 0.0035 0.0065 0.1276
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0011 0.0009 0.0045
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0011 0.0009 0.0045
Trichomonas vaginalis PIKK family atypical protein kinase 0.0448 0.1025 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0448 0.1025 1
Brugia malayi RNase H family protein 0.0027 0.0046 0.0253
Echinococcus granulosus GPCR family 2 0.0015 0.0019 0.0018
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0086 0.0184 0.993
Loa Loa (eye worm) hypothetical protein 0.0048 0.0096 0.0535
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0011 0.0009 0.0186
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0008 0.0002 0.0001
Echinococcus multilocularis geminin 0.0376 0.0857 0.0856
Trypanosoma brucei RNA helicase, putative 0.0267 0.0603 0.5882
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0065 0.3491
Schistosoma mansoni ap endonuclease 0.002 0.0031 0.0174
Entamoeba histolytica exodeoxyribonuclease III, putative 0.002 0.0031 0.0291
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0448 0.1025 0.2957
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0011 0.0009 0.0045
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0086 0.0184 0.0183
Schistosoma mansoni ap endonuclease 0.002 0.0031 0.0174
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.002 0.0031 0.0592
Echinococcus multilocularis peptidase Clp (S14 family) 0.0057 0.0116 0.0115
Schistosoma mansoni cpg binding protein 0.0031 0.0056 0.0319
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0037 0.0358
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0009 0.0045
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0065 0.0064
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0065 0.3491
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0086 0.0184 0.1787
Loa Loa (eye worm) hypothetical protein 0.0011 0.0009 0.0045
Echinococcus multilocularis Zinc finger, PHD finger 0.0086 0.0184 0.0183
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0086 0.0184 0.0529
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0086 0.0184 0.1795
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0008 0.0002 0.0001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0448 0.1025 1
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0025 0.0043 0.1572
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0009 0.0045
Loa Loa (eye worm) hypothetical protein 0.0011 0.0009 0.0045
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0025 0.0043 0.0826
Loa Loa (eye worm) hypothetical protein 0.0035 0.0065 0.0364
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0086 0.0184 0.1795
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0015 0.0019 0.0018
Schistosoma mansoni ferritin light chain 0.0009 0.0005 0.0022
Giardia lamblia Hypothetical protein 0.0086 0.0184 0.1541
Echinococcus multilocularis expressed protein 0.0009 0.0005 0.0004
Schistosoma mansoni ferritin 0.0009 0.0005 0.0022
Mycobacterium tuberculosis Conserved protein 0.0035 0.0065 0.1276
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0086 0.0184 0.1795
Plasmodium falciparum importin beta, putative 0.0028 0.0049 0.2609
Brugia malayi RNA, U transporter 1 0.008 0.017 0.0954
Trypanosoma cruzi ribonuclease H1, putative 0.0027 0.0046 0.0129
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0011 0.0009 0.0047
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0065 0.0637
Onchocerca volvulus 0.0035 0.0065 0.1491
Echinococcus multilocularis muscleblind protein 0.0768 0.1769 0.1768
Toxoplasma gondii exonuclease III APE 0.002 0.0031 0.0291
Trichomonas vaginalis CAMK family protein kinase 0.0105 0.0227 0.2214
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0086 0.0184 0.1035
Brugia malayi photoreceptor-specific nuclear receptor 0.0011 0.0009 0.0045
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0049 0.047
Toxoplasma gondii histone lysine methyltransferase SET1 0.0059 0.012 0.1163
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0031 0.0086
Schistosoma mansoni aldehyde dehydrogenase 0.0121 0.0266 0.1546
Onchocerca volvulus 0.0025 0.0043 0.0965
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0086 0.0184 0.0529
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0448 0.1025 0.2957
Schistosoma mansoni dishevelled 0.001 0.0006 0.0028
Onchocerca volvulus Ribonuclease H1 homolog 0.0027 0.0046 0.1035
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0025 0.0482
Trypanosoma brucei retrotransposon hot spot protein 4 (RHS4), interrupted 0.0033 0.006 0.0573
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0065 0.1276
Echinococcus granulosus microtubule associated protein 2 0.0745 0.1714 0.1713
Trichomonas vaginalis PIKK family atypical protein kinase 0.0448 0.1025 1
Brugia malayi regulator of G-protein signaling egl-10 0.001 0.0006 0.0027
Schistosoma mansoni aldehyde dehydrogenase 0.0121 0.0266 0.1546
Schistosoma mansoni hypothetical protein 0.0267 0.0603 0.3516
Loa Loa (eye worm) hypothetical protein 0.0019 0.0028 0.0151
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0065 0.1276
Echinococcus multilocularis regulator of G protein signaling 7 0.001 0.0006 0.0005
Brugia malayi TAR-binding protein 0.0068 0.0142 0.08
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0011 0.0009 0.0045
Trypanosoma brucei polo-like protein kinase 0.0105 0.0227 0.2206
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0086 0.0184 0.1787
Entamoeba histolytica hypothetical protein 0.0086 0.0184 0.1787
Leishmania major importin beta-1 subunit, putative 0.0023 0.0037 0.0098
Echinococcus multilocularis ferritin 0.0009 0.0005 0.0004
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0109 0.0238 0.0237
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0049 0.0048
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0086 0.0184 0.1795
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0019 0.0028 0.053
Brugia malayi RNase H family protein 0.0027 0.0046 0.0253
Brugia malayi hypothetical protein 0.001 0.0006 0.0027
Mycobacterium leprae conserved hypothetical protein 0.0086 0.0184 0.993
Schistosoma mansoni phosphoglucomutase 0.0027 0.0046 0.0261
Loa Loa (eye worm) hypothetical protein 0.0768 0.1769 1
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0195 0.0438 0.0437
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0043 0.0114
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0208 0.0466 0.1343
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0086 0.0184 0.0183
Entamoeba histolytica hypothetical protein 0.0109 0.0238 0.2313
Trypanosoma brucei ribonuclease H1 0.0027 0.0046 0.0436
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0011 0.0009 0.0008
Loa Loa (eye worm) phosphatidylinositol 3 0.0448 0.1025 0.5791
Mycobacterium ulcerans bacterioferritin BfrA 0.0009 0.0005 0.0142
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0025 0.0482
Mycobacterium leprae Probable lipase LipE 0.0035 0.0065 0.3491
Treponema pallidum exodeoxyribonuclease (exoA) 0.002 0.0031 0.1444
Trichomonas vaginalis PIKK family atypical protein kinase 0.0167 0.0371 0.3616
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0448 0.1025 1
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0009 0.0047
Schistosoma mansoni hypothetical protein 0.0086 0.0184 0.1069
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0043 0.0235
Echinococcus multilocularis muscleblind protein 1 0.0768 0.1769 0.1768
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0087 0.0185 0.6959
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0009 0.0047
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0009 0.0008
Trichomonas vaginalis PIKK family atypical protein kinase 0.0253 0.0571 0.557
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0011 0.0009 0.0008
Schistosoma mansoni regulator of G protein signaling 0.001 0.0006 0.0028
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0087 0.0185 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0448 0.1025 1
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0087 0.0185 0.0184
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0065 0.0637
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0086 0.0184 0.1035
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0009 0.0045
Loa Loa (eye worm) hypothetical protein 0.0025 0.0043 0.0235
Loa Loa (eye worm) RNA binding protein 0.0068 0.0142 0.08
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0086 0.0184 0.1787
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0015 0.0019 0.0018
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.001 0.0006 0.0027
Trichomonas vaginalis PIKK family atypical protein kinase 0.0448 0.1025 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0009 0.0045
Brugia malayi beta-lactamase family protein 0.0035 0.0065 0.0364
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0043 0.1572
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0448 0.1025 0.1024
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0043 0.1572
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0086 0.0184 0.1787
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0142 0.0826
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.4311 1 1
Brugia malayi nuclear hormone receptor 0.0011 0.0009 0.0045
Mycobacterium tuberculosis Conserved hypothetical protein 0.0086 0.0184 0.3629
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0225 0.0505 1
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0142 0.0826
Trypanosoma brucei unspecified product 0.0033 0.006 0.0573
Brugia malayi RNase H family protein 0.0027 0.0046 0.0253
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0011 0.0009 0.0047
Loa Loa (eye worm) phosphatidylinositol 3 0.0086 0.0184 0.1035
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.001 0.0006 0.0027
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0086 0.0184 0.05
Echinococcus multilocularis 0.0086 0.0184 0.0183
Trichomonas vaginalis CAMK family protein kinase 0.0105 0.0227 0.2214
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0011 0.0009 0.0047
Echinococcus multilocularis tar DNA binding protein 0.0068 0.0142 0.0142
Entamoeba histolytica hypothetical protein 0.0086 0.0184 0.1787
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0009 0.0008
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0065 0.1276
Schistosoma mansoni hypothetical protein 0.0015 0.0019 0.0106
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0009 0.0045
Trichomonas vaginalis PIKK family atypical protein kinase 0.0448 0.1025 1
Mycobacterium ulcerans lipase LipD 0.0035 0.0065 0.2429
Schistosoma mansoni microtubule-associated protein tau 0.0745 0.1714 1
Loa Loa (eye worm) hypothetical protein 0.0253 0.0571 0.3223
Loa Loa (eye worm) hypothetical protein 0.0086 0.0184 0.1035
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0253 0.0571 0.057
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0043 0.0114
Mycobacterium ulcerans beta-lactamase 0.0035 0.0065 0.2429
Brugia malayi Steroid receptor seven-up type 2 0.0011 0.0009 0.0045
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0011 0.0009 0.0045
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0065 0.0364
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0086 0.0184 0.1795
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0065 0.0364
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0087 0.0185 1
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0086 0.0184 0.1069
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0031 0.0301
Loa Loa (eye worm) hypothetical protein 0.0035 0.0065 0.0364
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0288 0.0652 0.1881
Schistosoma mansoni apoferritin-2 0.0009 0.0005 0.0022
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.003 0.0053 0.283
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0031 0.0169
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0086 0.0184 0.1035
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0011 0.0009 0.0008
Schistosoma mansoni hypothetical protein 0.0015 0.0019 0.0106
Loa Loa (eye worm) hypothetical protein 0.0033 0.006 0.0335
Schistosoma mansoni retinoic acid receptor RXR 0.0011 0.0009 0.0047
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0253 0.0571 0.5566
Loa Loa (eye worm) hypothetical protein 0.001 0.0006 0.0027
Trichomonas vaginalis PIKK family atypical protein kinase 0.0448 0.1025 1
Onchocerca volvulus 0.0031 0.0056 0.1268
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0037 0.0358
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0025 0.0043 0.1572
Trichomonas vaginalis PIKK family atypical protein kinase 0.0448 0.1025 1
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0086 0.0184 0.1069
Echinococcus granulosus tar DNA binding protein 0.0068 0.0142 0.0142
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0086 0.0184 0.0183
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0448 0.1025 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0448 0.1025 1
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0374 0.0853 0.4973
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0048 0.0096 0.0535
Brugia malayi hypothetical protein 0.001 0.0006 0.0027
Echinococcus granulosus ecdysone induced protein 78C 0.0011 0.0009 0.0008
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0105 0.0227 0.0617
Loa Loa (eye worm) hypothetical protein 0.0019 0.0028 0.0151
Echinococcus granulosus expressed protein 0.0009 0.0005 0.0004
Leishmania major ribonuclease H1, putative 0.0027 0.0046 0.0122
Echinococcus multilocularis dnaJ subfamily B 0.0441 0.1009 0.1008
Echinococcus granulosus mixed lineage leukemia protein mll 0.0008 0.0002 0.0001
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0086 0.0184 0.1787
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0065 0.1276
Onchocerca volvulus 0.0035 0.0065 0.1491
Schistosoma mansoni ferritin 0.0009 0.0005 0.0022
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0031 0.0169
Loa Loa (eye worm) phosphatidylinositol 3 0.0086 0.0184 0.1035
Loa Loa (eye worm) hypothetical protein 0.0019 0.0028 0.0151
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0086 0.0184 0.1795
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0086 0.0184 0.993
Loa Loa (eye worm) DIX domain-containing protein 0.001 0.0006 0.0027
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0086 0.0184 0.1787
Onchocerca volvulus Segment polarity protein dishevelled homolog 0.001 0.0006 0.0111

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) = 1.7 uM Antiviral activity against HIV1 infected CEM cells ChEMBL. 17663538
EC50 (binding) = 2.4 uM Inhibition of HIV-1 reverse transcriptase. ChEMBL. 12723956
EC50 (binding) = 2.4 uM Inhibition of HIV-1 reverse transcriptase. ChEMBL. 12723956
IC50 (binding) = 4.94 uM Inhibition of HIV1 NL4-3 reverse transcriptase ChEMBL. 17663538
IC50 (binding) = 4.94 uM Inhibition of HIV1 NL4-3 reverse transcriptase ChEMBL. 17663538
TC50 (ADMET) = 27.2 uM Toxicity against CEM cells ChEMBL. 17663538
TC50 (ADMET) = 27.2 uM Toxicity against CEM cells ChEMBL. 17663538

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

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