TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 645.798 | Formula: C40H39N9
H donors: 4 H acceptors: 2 LogP: 7.95 Rotable bonds: 11
Rule of 5 violations (Lipinski): 2
SMILES: CC(NC(=N)c1ccc2c(c1)nc([nH]2)c1ccc(cc1)N(c1ccc(cc1)c1nc2c([nH]1)ccc(c2)C(=N)NC(C)C)c1ccccc1)C
InChi: 1S/C40H39N9/c1-24(2)43-37(41)28-14-20-33-35(22-28)47-39(45-33)26-10-16-31(17-11-26)49(30-8-6-5-7-9-30)32-18-12-27(13-19-32)40-46-34-21-15-29(23-36(34)48-40)38(42)44-25(3)4/h5-25H,1-4H3,(H2,41,43)(H2,42,44)(H,45,47)(H,46,48)
InChiKey: IFRDHHIQTSNIJG-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0103	0.0424	0.0797
Schistosoma mansoni	hypothetical protein	0.0039	0.0028	0.0081
Echinococcus multilocularis	Niemann Pick C1 protein	0.0136	0.0627	0.0627
Brugia malayi	beta-lactamase family protein	0.0038	0.0017	0.0033
Schistosoma mansoni	serine/threonine protein kinase	0.0299	0.1638	0.4683
Mycobacterium ulcerans	3-oxoacyl-(acyl carrier protein) synthase II	0.0133	0.0611	1
Mycobacterium leprae	PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE)	0.0046	0.0073	0.1814
Trypanosoma cruzi	hypothetical protein, conserved	0.0038	0.0017	0.004
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0017	0.0026
Trichomonas vaginalis	AGC family protein kinase	0.0036	0.0007	0.0007
Mycobacterium ulcerans	Type I modular polyketide synthase	0.0046	0.0073	0.0933
Loa Loa (eye worm)	beta-ketoacyl synthase domain-containing protein	0.0133	0.0611	0.1151
Trichomonas vaginalis	AGC family protein kinase	0.0887	0.5278	1
Toxoplasma gondii	ABC1 family protein	0.0038	0.0017	0.0027
Brugia malayi	hypothetical protein	0.0252	0.1348	0.2555
Trichomonas vaginalis	AGC family protein kinase	0.0299	0.1638	0.3099
Trichomonas vaginalis	AGC family protein kinase	0.0036	0.0007	0.0007
Entamoeba histolytica	p21-activated kinase	0.0036	0.0007	0.0014
Echinococcus multilocularis	ribosomal protein s6 kinase beta 1	0.0299	0.1638	0.1638
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0017	0.0026
Schistosoma mansoni	serine/threonine-protein kinase	0.0599	0.3497	1
Echinococcus multilocularis	protein kinase c epsilon type	0.0299	0.1638	0.1638
Echinococcus multilocularis	Ribosomal protein S6 kinase beta 2	0.0299	0.1638	0.1638
Mycobacterium tuberculosis	Probable polyketide synthase Pks15	0.0046	0.0073	0.0442
Echinococcus multilocularis	sodium:potassium dependent atpase beta subunit	0.0563	0.3275	0.3275
Mycobacterium leprae	3-oxoacyl-[acyl-carrier-protein] synthase 2 KasB (BETA-KETOACYL-ACP SYNTHASE) (KAS I)	0.0087	0.0323	1
Loa Loa (eye worm)	AGC/RSK/P70 protein kinase	0.0862	0.5128	0.9716
Entamoeba histolytica	protein kinase, putative	0.058	0.3378	0.6401
Schistosoma mansoni	serine/threonine protein kinase	0.058	0.3378	0.966
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0036	0.0007	0.0014
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0159	0.0771	0.1455
Echinococcus multilocularis	protein patched	0.0041	0.0038	0.0038
Loa Loa (eye worm)	hypothetical protein	0.0103	0.0424	0.0797
Mycobacterium tuberculosis	3-oxoacyl-[acyl-carrier protein] synthase 2 KasB (beta-ketoacyl-ACP synthase) (KAS I)	0.0087	0.0323	0.2436
Trichomonas vaginalis	AGC family protein kinase	0.0036	0.0007	0.0007
Brugia malayi	beta-lactamase	0.0038	0.0017	0.0033
Leishmania major	protein kinase, putative	0.0036	0.0007	0.0062
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0038	0.0017	0.0017
Leishmania major	protein kinase, putative	0.0036	0.0007	0.0062
Trichomonas vaginalis	AGC family protein kinase	0.0887	0.5278	1
Trypanosoma cruzi	beta-ketoacyl synthase family protein, putative	0.0133	0.0611	0.1738
Loa Loa (eye worm)	hypothetical protein	0.005	0.0094	0.0172
Schistosoma mansoni	serine/threonine protein kinase	0.0299	0.1638	0.4683
Trichomonas vaginalis	D-aminoacylase, putative	0.0038	0.0017	0.0026
Mycobacterium ulcerans	Type I modular polyketide synthase	0.0046	0.0073	0.0933
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0159	0.0771	0.0771
Schistosoma mansoni	serine/threonine protein kinase	0.0299	0.1638	0.4683
Echinococcus granulosus	Ribosomal protein S6 kinase beta 2	0.0299	0.1638	0.4683
Chlamydia trachomatis	3-oxoacyl-ACP synthase	0.0133	0.0611	0.5
Loa Loa (eye worm)	AGC/AKT protein kinase	0.0887	0.5278	1
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0073	0.0131
Schistosoma mansoni	3-oxoacyl-[ACP] synthase	0.0133	0.0611	0.1746
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0035	0.0003	0.0007
Trichomonas vaginalis	AGC family protein kinase	0.0887	0.5278	1
Echinococcus granulosus	protein kinase c epsilon type	0.0299	0.1638	0.4683
Entamoeba histolytica	protein kinase, putative	0.0299	0.1638	0.3103
Echinococcus granulosus	Niemann Pick C1 protein	0.0136	0.0627	0.1792
Mycobacterium ulcerans	polyketide synthase	0.0046	0.0073	0.0933
Loa Loa (eye worm)	hypothetical protein	0.0095	0.0374	0.0702
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.024	0.1271	1
Trichomonas vaginalis	penicillin-binding protein, putative	0.0038	0.0017	0.0026
Echinococcus multilocularis	protein kinase c iota type	0.0299	0.1638	0.1638
Mycobacterium ulcerans	3-oxoacyl-(acyl carrier protein) synthase II	0.0133	0.0611	1
Leishmania major	serine/threonine-protein kinase a, putative	0.0036	0.0007	0.0062
Trichomonas vaginalis	AGC family protein kinase	0.0036	0.0007	0.0007
Echinococcus granulosus	Protein patched homolog 1	0.0041	0.0038	0.0107
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0599	0.3497	0.6627
Trypanosoma brucei	NEK family Serine/threonine-protein kinase, putative	0.0036	0.0007	0.0007
Echinococcus multilocularis	Glutaredoxin protein 5	0.0563	0.3275	0.3275
Entamoeba histolytica	protein kinase, putative	0.0036	0.0007	0.0014
Loa Loa (eye worm)	AGC/RSK/RSK protein kinase	0.0299	0.1638	0.3099
Mycobacterium leprae	Probable polyketide synthase Pks1	0.0046	0.0073	0.1814
Leishmania major	rac serine-threonine kinase, putative,protein kinase, putative	0.0036	0.0007	0.0062
Brugia malayi	oxidoreductase, zinc-binding dehydrogenase family protein	0.0046	0.0073	0.0138
Entamoeba histolytica	protein kinase, putative	0.0036	0.0007	0.0014
Entamoeba histolytica	protein kinase, putative	0.0036	0.0007	0.0014
Echinococcus multilocularis	nervana 2	0.0563	0.3275	0.3275
Mycobacterium leprae	PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA	0.0046	0.0073	0.1814
Trichomonas vaginalis	AGC family protein kinase	0.0036	0.0007	0.0007
Mycobacterium ulcerans	phenolpthiocerol synthesis type-I polyketide synthase PpsC	0.0046	0.0073	0.0933
Brugia malayi	Protein kinase domain containing protein	0.0887	0.5278	1
Trichomonas vaginalis	AGC family protein kinase	0.0299	0.1638	0.3099
Entamoeba histolytica	hypothetical protein	0.0036	0.0007	0.0014
Schistosoma mansoni	atypical protein kinase C	0.0299	0.1638	0.4683
Schistosoma mansoni	hypothetical protein	0.0039	0.0028	0.0081
Trichomonas vaginalis	AGC family protein kinase	0.058	0.3378	0.6399
Entamoeba histolytica	protein kinase, putative	0.0036	0.0007	0.0014
Schistosoma mansoni	serine/threonine-protein kinase	0.0599	0.3497	1
Trichomonas vaginalis	AGC family protein kinase	0.0036	0.0007	0.0007
Trichomonas vaginalis	AGC family protein kinase	0.0036	0.0007	0.0007
Toxoplasma gondii	AGC kinase	0.0862	0.5128	1
Trypanosoma cruzi	beta-ketoacyl synthase family protein, putative	0.0133	0.0611	0.1738
Mycobacterium tuberculosis	Polyketide synthase Pks2	0.0046	0.0073	0.0442
Trichomonas vaginalis	AGC family protein kinase	0.0036	0.0007	0.0007
Trichomonas vaginalis	AGC family protein kinase	0.0036	0.0007	0.0007
Trichomonas vaginalis	AGC family protein kinase	0.0036	0.0007	0.0007
Schistosoma mansoni	serine/threonine protein kinase	0.0299	0.1638	0.4683
Echinococcus granulosus	Glutaredoxin protein 5	0.0563	0.3275	0.9363
Echinococcus granulosus	lysosomal alpha glucosidase	0.0159	0.0771	0.2204
Trypanosoma brucei	beta-ketoacyl-ACP synthase	0.0133	0.0611	0.1151
Echinococcus granulosus	NDR protein kinase	0.0299	0.1638	0.4683
Trichomonas vaginalis	AGC family protein kinase	0.0299	0.1638	0.3099
Entamoeba histolytica	protein kinase 2, putative	0.0575	0.3348	0.6343
Mycobacterium tuberculosis	Polyketide synthase Pks13	0.0046	0.0073	0.0442
Mycobacterium tuberculosis	Probable multifunctional mycocerosic acid synthase membrane-associated Mas	0.0046	0.0073	0.0442
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0038	0.0017	0.0049
Echinococcus granulosus	expressed conserved protein	0.0089	0.0338	0.0967
Leishmania major	protein kinase, putative,serine/threonine protein kinase, putative	0.0036	0.0007	0.0062
Loa Loa (eye worm)	hypothetical protein	0.0252	0.1348	0.255
Mycobacterium leprae	PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE	0.0046	0.0073	0.1814
Echinococcus multilocularis	neutral alpha glucosidase AB	0.0035	0.0003	0.0003
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0038	0.0017	0.0026
Plasmodium vivax	hypothetical protein, conserved	0.0038	0.0017	0.003
Brugia malayi	protein kinase C II.	0.0299	0.1638	0.3103
Trichomonas vaginalis	AGC family protein kinase	0.058	0.3378	0.6399
Brugia malayi	Protein kinase domain containing protein	0.058	0.3378	0.6401
Trichomonas vaginalis	ribosomal protein S6 kinase, 90kD, polypeptide, putative	0.0036	0.0007	0.0007
Loa Loa (eye worm)	AGC/NDR protein kinase	0.0299	0.1638	0.3099
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.0599	0.3497	1
Plasmodium vivax	rac-beta serine/threonine protein kinase, putative	0.0575	0.3348	1
Brugia malayi	Bromodomain containing protein	0.0077	0.0261	0.0495
Brugia malayi	Beta-ketoacyl synthase, N-terminal domain containing protein	0.0133	0.0611	0.1157
Mycobacterium tuberculosis	Probable polyketide synthase Pks9	0.0046	0.0073	0.0442
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0159	0.0771	0.1461
Mycobacterium tuberculosis	Phenolpthiocerol synthesis type-I polyketide synthase PpsC	0.0046	0.0073	0.0442
Trypanosoma cruzi	serine/threonine protein kinase, putative	0.0036	0.0007	0.0011
Mycobacterium ulcerans	phenolpthiocerol synthesis type-I polyketide synthase PpsA	0.0046	0.0073	0.0933
Toxoplasma gondii	AMP-binding enzyme domain-containing protein	0.0046	0.0073	0.0135
Brugia malayi	Beta-ketoacyl synthase, N-terminal domain containing protein	0.0046	0.0073	0.0138
Echinococcus multilocularis	Niemann Pick C1 protein	0.0095	0.0374	0.0374
Trypanosoma cruzi	NEK family Serine/threonine-protein kinase, putative	0.0036	0.0007	0.0011
Trichomonas vaginalis	AGC family protein kinase	0.0036	0.0007	0.0007
Toxoplasma gondii	beta-ketoacyl synthase, N-terminal domain-containing protein	0.0046	0.0073	0.0135
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0036	0.0007	0.0014
Brugia malayi	latrophilin 2 splice variant baaae	0.007	0.0221	0.042
Trypanosoma cruzi	hypothetical protein, conserved	0.0038	0.0017	0.004
Echinococcus granulosus	ribosomal protein S6 kinase alpha 3	0.0299	0.1638	0.4683
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0051	0.0104	0.0196
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0038	0.0065
Leishmania major	beta-ketoacyl synthase family protein, putative,3-oxoacyl-acyl carrier protein synthase ii, putative	0.0133	0.0611	1
Trypanosoma cruzi	Serine/threonine-protein kinase NEK21, putative	0.0036	0.0007	0.0011
Echinococcus granulosus	3 oxoacyl acyl carrier protein synthase	0.0133	0.0611	0.1746
Trypanosoma cruzi	NIMA-related kinase, putative	0.0036	0.0007	0.0011
Onchocerca volvulus		0.0092	0.0355	1
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0081	0.0146
Entamoeba histolytica	Niemann-Pick C1 protein, putative	0.0095	0.0374	0.0709
Echinococcus multilocularis	expressed conserved protein	0.0089	0.0338	0.0338
Entamoeba histolytica	protein kinase, putative	0.0036	0.0007	0.0014
Entamoeba histolytica	protein kinase, putative	0.0887	0.5278	1
Echinococcus granulosus	serine:threonine protein kinase N2	0.0299	0.1638	0.4683
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0599	0.3497	0.6627
Onchocerca volvulus		0.0051	0.0104	0.2554
Echinococcus multilocularis	Protein kinase C, brain isozyme	0.0299	0.1638	0.1638
Echinococcus multilocularis	sterol regulatory element binding protein	0.0041	0.0038	0.0038
Trichomonas vaginalis	AGC family protein kinase	0.0036	0.0007	0.0007
Echinococcus granulosus	nervana 2	0.0563	0.3275	0.9363
Toxoplasma gondii	type I fatty acid synthase, putative	0.0046	0.0073	0.0135
Loa Loa (eye worm)	AGC/RSK/MSK protein kinase	0.0299	0.1638	0.3099
Entamoeba histolytica	protein kinase, putative	0.0887	0.5278	1
Plasmodium falciparum	RAC-beta serine/threonine protein kinase	0.0575	0.3348	1
Leishmania major	folate/biopterin transporter, putative	0.0036	0.0007	0.0062
Mycobacterium leprae	Polyketide synthase Pks13	0.0046	0.0073	0.1814
Mycobacterium tuberculosis	Polyketide synthase Pks12	0.0046	0.0073	0.0442
Echinococcus multilocularis	serine threonine protein kinase nrc serine threonine protein kinase gad	0.0575	0.3348	0.3348
Trypanosoma brucei	protein kinase, putative	0.0036	0.0007	0.0007
Mycobacterium ulcerans	polyketide synthase Pks9	0.0046	0.0073	0.0933
Echinococcus granulosus	protein kinase C gamma type	0.0299	0.1638	0.4683
Onchocerca volvulus		0.0046	0.0073	0.164
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0029	0.0047
Loa Loa (eye worm)	AGC/DMPK/GEK protein kinase	0.0299	0.1638	0.3099
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0037	0.0013	0.0013
Schistosoma mansoni	hypothetical protein	0.0039	0.0028	0.0081
Plasmodium vivax	3-oxoacyl-[acyl-carrier-protein] synthase i/ii, putative	0.0133	0.0611	0.1807
Echinococcus granulosus	serine threonine protein kinase nrc	0.0575	0.3348	0.9572
Trypanosoma cruzi	Serine/threonine-protein kinase NEK17, putative	0.0036	0.0007	0.0011
Schistosoma mansoni	alpha-glucosidase	0.0137	0.0633	0.1811
Leishmania major	hypothetical protein, conserved	0.0038	0.0017	0.0228
Trichomonas vaginalis	AGC family protein kinase	0.0323	0.1788	0.3383
Echinococcus multilocularis	3 oxoacyl (acyl carrier protein) synthase	0.0133	0.0611	0.0611
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.0097	0.0383	0.1095
Toxoplasma gondii	protein kinase domain-containing protein	0.0036	0.0007	0.0007
Mycobacterium tuberculosis	Probable polyketide synthase Pks5	0.0046	0.0073	0.0442
Echinococcus multilocularis	ribosomal protein S6 kinase alpha 3	0.0299	0.1638	0.1638
Schistosoma mansoni	hypothetical protein	0.0039	0.0028	0.0081
Echinococcus multilocularis	serine:threonine protein kinase 38	0.0299	0.1638	0.1638
Loa Loa (eye worm)	beta-lactamase	0.0038	0.0017	0.0026
Echinococcus granulosus	serine/threonine protein kinase	0.0599	0.3497	1
Trypanosoma brucei	Serine/threonine-protein kinase NEK21, putative	0.0036	0.0007	0.0007
Toxoplasma gondii	calcium dependent protein kinase CDPK7	0.0036	0.0007	0.0007
Mycobacterium ulcerans	phenolpthiocerol synthesis type-I polyketide synthase PpsD	0.0046	0.0073	0.0933
Trichomonas vaginalis	esterase, putative	0.0038	0.0017	0.0026
Echinococcus multilocularis	3 phosphoinositide dependent protein kinase 1	0.058	0.3378	0.3378
Mycobacterium tuberculosis	Probable membrane bound polyketide synthase Pks6	0.0046	0.0073	0.0442
Trichomonas vaginalis	AGC family protein kinase	0.0887	0.5278	1
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.0036	0.0007	0.0011
Schistosoma mansoni	survival motor neuron protein	0.0051	0.0104	0.0296
Trichomonas vaginalis	AGC family protein kinase	0.0036	0.0007	0.0007
Echinococcus granulosus	nervana 2	0.0563	0.3275	0.9363
Mycobacterium tuberculosis	Polyketide synthetase MbtC (polyketide synthase)	0.0046	0.0073	0.0442
Trichomonas vaginalis	AGC family protein kinase	0.0036	0.0007	0.0007
Mycobacterium ulcerans	multifunctional mycocerosic acid synthase membrane-associated Mas	0.0046	0.0073	0.0933
Mycobacterium tuberculosis	Phenolpthiocerol synthesis type-I polyketide synthase PpsD	0.0046	0.0073	0.0442
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0017	0.0026
Plasmodium falciparum	3-oxoacyl-acyl-carrier protein synthase I/II	0.0133	0.0611	0.1807
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0159	0.0771	0.0771
Schistosoma mansoni	cellular tumor antigen P53	0.0048	0.0081	0.0231
Brugia malayi	Hr1 repeat family protein	0.0299	0.1638	0.3103
Mycobacterium ulcerans	phenolpthiocerol synthesis type-I polyketide synthase PpsB	0.0046	0.0073	0.0933
Trichomonas vaginalis	penicillin-binding protein, putative	0.0038	0.0017	0.0026
Trypanosoma cruzi	Serine/threonine-protein kinase NEK17, putative	0.0036	0.0007	0.0011
Trypanosoma cruzi	Serine/threonine-protein kinase NEK21, putative	0.0036	0.0007	0.0011
Trypanosoma brucei	serine/threonine-protein kinase NrkA	0.0036	0.0007	0.0007
Onchocerca volvulus		0.0048	0.0081	0.1877
Mycobacterium ulcerans	phenolpthiocerol synthesis type-I polyketide synthase PpsE	0.0046	0.0073	0.0933
Trichomonas vaginalis	D-aminoacylase, putative	0.0038	0.0017	0.0026
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0017	0.0026
Trichomonas vaginalis	AGC family protein kinase	0.0036	0.0007	0.0007
Trypanosoma cruzi	Protein kinase B	0.0599	0.3497	1
Mycobacterium leprae	Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas	0.0046	0.0073	0.1814
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0103	0.0424	0.0803
Trichomonas vaginalis	AGC family protein kinase	0.0036	0.0007	0.0007
Trichomonas vaginalis	3-phosphoinositide dependent protein kinase-1, putative	0.0036	0.0007	0.0007
Trichomonas vaginalis	D-aminoacylase, putative	0.0038	0.0017	0.0026
Trypanosoma brucei	hypothetical protein, conserved	0.0038	0.0017	0.0026
Schistosoma mansoni	serine/threonine protein kinase	0.0299	0.1638	0.4683
Brugia malayi	Bromodomain containing protein	0.0039	0.0028	0.0053
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0044	0.0076
Entamoeba histolytica	protein kinase, putative	0.0862	0.5128	0.9716
Toxoplasma gondii	type I fatty acid synthase, putative	0.0046	0.0073	0.0135
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0103	0.0424	0.0803
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.0575	0.3348	0.9571
Trypanosoma cruzi	NIMA-related kinase, putative	0.0036	0.0007	0.0011
Brugia malayi	Niemann-Pick C1 protein precursor	0.0095	0.0374	0.0709
Toxoplasma gondii	3-oxoacyl-acyl-carrier protein synthase I/II, putative	0.0133	0.0611	0.1185
Schistosoma mansoni	patched 1	0.0041	0.0038	0.0107
Loa Loa (eye worm)	AGC/PDK1 protein kinase	0.058	0.3378	0.6399
Echinococcus granulosus	tumor protein p63	0.0326	0.1807	0.5167
Mycobacterium ulcerans	polyketide synthase	0.0046	0.0073	0.0933
Echinococcus multilocularis	protein dispatched 1	0.0047	0.0073	0.0073
Echinococcus granulosus	ribosomal protein s6 kinase beta 1	0.0299	0.1638	0.4683
Schistosoma mansoni	alpha-glucosidase	0.0137	0.0633	0.1811
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0035	0.0003	0.0007
Mycobacterium ulcerans	fatty acid synthase Fas	0.0046	0.0073	0.0933
Brugia malayi	beta-lactamase family protein	0.0038	0.0017	0.0033
Mycobacterium tuberculosis	Phenolpthiocerol synthesis type-I polyketide synthase PpsA	0.0046	0.0073	0.0442
Echinococcus granulosus	survival motor neuron protein 1	0.0252	0.1348	0.3855
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0036	0.0007	0.0014
Schistosoma mansoni	hypothetical protein	0.007	0.0221	0.0633
Loa Loa (eye worm)	hypothetical protein	0.0299	0.1638	0.3099
Mycobacterium ulcerans	Type I modular polyketide synthase	0.0046	0.0073	0.0933
Schistosoma mansoni	hypothetical protein	0.0051	0.0104	0.0296
Onchocerca volvulus	Fatty acid synthase homolog	0.0046	0.0073	0.164
Mycobacterium tuberculosis	Probable fatty acid synthase Fas (fatty acid synthetase)	0.0046	0.0073	0.0442
Echinococcus multilocularis	nervana 2	0.0563	0.3275	0.3275
Entamoeba histolytica	hypothetical protein	0.0036	0.0007	0.0014
Mycobacterium tuberculosis	3-oxoacyl-[acyl-carrier protein] synthase 1 KasA (beta-ketoacyl-ACP synthase) (KAS I)	0.0087	0.0323	0.2436
Mycobacterium tuberculosis	Probable polyketide synthase Pks8	0.0046	0.0073	0.0442
Trypanosoma cruzi	serine/threonine-protein kinase NRKB, putative	0.0036	0.0007	0.0011
Echinococcus granulosus	sterol regulatory element binding protein	0.0041	0.0038	0.0107
Trichomonas vaginalis	AGC family protein kinase	0.0036	0.0007	0.0007
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0036	0.0007	0.0014
Mycobacterium leprae	3-oxoacyl-[acyl-carrier-protein] synthase 1 KasA (BETA-KETOACYL-ACP SYNTHASE) (KAS I)	0.0087	0.0323	1
Trichomonas vaginalis	AGC family protein kinase	0.0887	0.5278	1
Schistosoma mansoni	alpha glucosidase	0.0035	0.0003	0.001
Schistosoma mansoni	serine/threonine protein kinase	0.0299	0.1638	0.4683
Echinococcus multilocularis	serine:threonine protein kinase N2	0.0299	0.1638	0.1638
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0056	0.0099
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0017	0.0026
Schistosoma mansoni	serine/threonine protein kinase	0.0299	0.1638	0.4683
Brugia malayi	Protein kinase domain containing protein	0.0299	0.1638	0.3103
Mycobacterium leprae	PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC	0.0046	0.0073	0.1814
Brugia malayi	p70 ribosomal S6 kinase beta	0.0862	0.5128	0.9716
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0038	0.0017	0.0049
Trichomonas vaginalis	serine/threonine-protein kinase sgk, putative	0.0287	0.1565	0.2961
Echinococcus granulosus	protein kinase c iota type	0.0299	0.1638	0.4683
Trichomonas vaginalis	AGC family protein kinase	0.0036	0.0007	0.0007
Brugia malayi	CHE-14 protein	0.0041	0.0038	0.0071
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0017	0.0026
Trypanosoma brucei	serine/threonine-protein kinase NRKB, putative	0.0036	0.0007	0.0007
Echinococcus granulosus	neutral alpha glucosidase AB	0.0035	0.0003	0.001
Echinococcus multilocularis	survival motor neuron protein 1	0.0252	0.1348	0.1348
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0037	0.0013	0.0037
Brugia malayi	phosphoinositide-dependent protein kinase I	0.058	0.3378	0.6401
Echinococcus multilocularis	serine:threonine protein kinase N2	0.0299	0.1638	0.1638
Loa Loa (eye worm)	AGC/PDK1 protein kinase	0.058	0.3378	0.6399
Giardia lamblia	Kinase, AGC PKA	0.0575	0.3348	0.5
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.0041	0.0038	0.0065
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0061	0.0164	0.0164
Echinococcus granulosus	calcium:calmodulin dependent protein kinase	0.0575	0.3348	0.9572
Trichomonas vaginalis	AGC family protein kinase	0.0887	0.5278	1
Mycobacterium ulcerans	polyketide synthase Pks13	0.0046	0.0073	0.0933
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0234	0.0437
Trichomonas vaginalis	conserved hypothetical protein	0.0041	0.0038	0.0065
Trichomonas vaginalis	AGC family protein kinase	0.0036	0.0007	0.0007
Trichomonas vaginalis	AGC family protein kinase	0.0036	0.0007	0.0007
Echinococcus granulosus	Niemann Pick C1 protein	0.0095	0.0374	0.1069
Trichomonas vaginalis	AGC family protein kinase	0.0887	0.5278	1
Loa Loa (eye worm)	hypothetical protein	0.007	0.0221	0.0413
Echinococcus multilocularis	tumor protein p63	0.0326	0.1807	0.1807
Trypanosoma brucei	rac serine-threonine kinase, putative	0.0887	0.5278	1
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0073	0.0131
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0035	0.0003	0.0007
Mycobacterium ulcerans	polyketide synthase MbtC	0.0046	0.0073	0.0933
Echinococcus granulosus	sodium:potassium dependent atpase beta subunit	0.0563	0.3275	0.9363
Echinococcus granulosus	beta LACTamase domain containing family member	0.0038	0.0017	0.0049
Echinococcus multilocularis	serine threonine protein kinase	0.0299	0.1638	0.1638
Loa Loa (eye worm)	AGC/PKC/ETA protein kinase	0.0299	0.1638	0.3099
Loa Loa (eye worm)	AGC/PKN protein kinase	0.0299	0.1638	0.3099
Schistosoma mansoni	serine/threonine kinase	0.0299	0.1638	0.4683
Echinococcus granulosus	Protein kinase C brain isozyme	0.0299	0.1638	0.4683
Mycobacterium leprae	PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD	0.0046	0.0073	0.1814
Echinococcus granulosus	3-phosphoinositide-dependent protein kinase 1	0.058	0.3378	0.966
Echinococcus multilocularis	rac serine:threonine kinase	0.0599	0.3497	0.3497
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0061	0.0164	0.0469
Wolbachia endosymbiont of Brugia malayi	3-oxoacyl-ACP synthase	0.0133	0.0611	0.5
Brugia malayi	Protein kinase domain containing protein	0.0299	0.1638	0.3103
Mycobacterium leprae	PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB	0.0046	0.0073	0.1814
Schistosoma mansoni	bromodomain containing protein	0.0065	0.0187	0.0534
Mycobacterium tuberculosis	Probable polyketide synthase Pks7	0.0046	0.0073	0.0442
Trichomonas vaginalis	AGC family protein kinase	0.058	0.3378	0.6399
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0038	0.0017	0.0033

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL449218

Bibliographic References

No literature references available for this target.

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Detailed information for compound 956780