Detailed information for compound 976973

Basic information

Technical information
  • TDR Targets ID: 976973
  • Name: methyl 2-[(3R,6R)-6-[(4E,6E)-deca-4,6-dienyl] -6-methoxy-3H-dioxin-3-yl]acetate
  • MW: 324.412 | Formula: C18H28O5
  • H donors: 0 H acceptors: 1 LogP: 3.69 Rotable bonds: 11
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCC/C=C/C=C/CCC[C@@]1(OC)OO[C@@H](C=C1)CC(=O)OC
  • InChi: 1S/C18H28O5/c1-4-5-6-7-8-9-10-11-13-18(21-3)14-12-16(22-23-18)15-17(19)20-2/h6-9,12,14,16H,4-5,10-11,13,15H2,1-3H3/b7-6+,9-8+/t16-,18+/m0/s1
  • InChiKey: NBDMNKOTFDFWNY-YXLHONABSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[(3R,6R)-6-[(4E,6E)-deca-4,6-dienyl]-6-methoxy-3H-dioxin-3-yl]acetic acid methyl ester
  • methyl 2-[(3R,6R)-6-[(4E,6E)-deca-4,6-dienyl]-6-methoxy-3H-1,2-dioxin-3-yl]ethanoate

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis lysyl tRNA synthetase 0.0028 0.0278 0.0273
Echinococcus granulosus nibrin 0.001 0.0041 0.0042
Brugia malayi Niemann-Pick C1 protein precursor 0.0095 0.1143 0.3986
Plasmodium falciparum protein kinase 6 0.0531 0.6752 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0048 0.0539 0.1869
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0018 0.0145 0.5126
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0007 0.0008 0.0002
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0015 0.0116 0.013
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0038 0.0402 0.0467
Trichomonas vaginalis sugar transporter, putative 0.0039 0.0418 0.2736
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0045 0.0046
Loa Loa (eye worm) hypothetical protein 0.0026 0.0253 0.0867
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0045 0.0046
Schistosoma mansoni notch 0.0008 0.0027 0.0025
Loa Loa (eye worm) hypothetical protein 0.0007 0.001 0.0014
Schistosoma mansoni hypothetical protein 0.0047 0.0519 0.0604
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0024 0.0224 0.5515
Schistosoma mansoni sugar transporter 0.0018 0.0145 0.0165
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0214 0.4369
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.0116 0.2323
Echinococcus multilocularis neurogenic locus protein delta 0.0008 0.0027 0.0021
Onchocerca volvulus 0.0018 0.0145 0.2726
Schistosoma mansoni notch 0.0008 0.0027 0.0025
Treponema pallidum DNA ligase (lig) 0.001 0.0041 0.3975
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0145 0.0951
Loa Loa (eye worm) hypothetical protein 0.001 0.0045 0.0137
Onchocerca volvulus Protein ultraspiracle homolog 0.001 0.0045 0.0762
Schistosoma mansoni glucose transport protein 0.0125 0.1529 0.1794
Trypanosoma brucei BRCA1 C Terminus (BRCT) domain containing protein, putative 0.001 0.0041 0.0752
Loa Loa (eye worm) TAR-binding protein 0.0061 0.071 0.2468
Loa Loa (eye worm) hypothetical protein 0.0008 0.0027 0.0075
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0116 0.0111
Echinococcus granulosus synaptic vesicle 2 protein 0.0018 0.0145 0.0165
Trichomonas vaginalis glucose transporter, putative 0.0039 0.0418 0.2736
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0232 0.0336
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0125 0.1529 0.1524
Loa Loa (eye worm) sugar transporter 0.0018 0.0145 0.049
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0045 0.0137
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0045 0.0137
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0038 0.0412 0.0603
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0018 0.0145 0.0207
Echinococcus multilocularis solute carrier family 22 0.0018 0.0145 0.014
Schistosoma mansoni protein kinase 0.0038 0.0412 0.0479
Loa Loa (eye worm) hypothetical protein 0.0008 0.0027 0.0075
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0045 0.0137
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.0214 0.7631
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0145 0.0951
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0145 0.0951
Loa Loa (eye worm) hypothetical protein 0.001 0.0041 0.0126
Loa Loa (eye worm) hypothetical protein 0.0018 0.0145 0.049
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0276 0.0948
Trypanosoma brucei sugar transporter, putative 0.0018 0.0145 0.2935
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0045 0.0137
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0214 0.7631
Onchocerca volvulus 0.0018 0.0145 0.2726
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0028 0.0278 0.1821
Trypanosoma brucei glucose transporter, putative 0.0039 0.0418 0.8662
Plasmodium falciparum protein kinase 7 0.0353 0.4468 0.6614
Schistosoma mansoni serine/threonine protein kinase 0.0038 0.0412 0.0479
Loa Loa (eye worm) hypothetical protein 0.0008 0.0027 0.0075
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0045 0.0046
Echinococcus multilocularis protein jagged 2 0.0008 0.0027 0.0021
Entamoeba histolytica hypothetical protein 0.0035 0.0366 0.3171
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.0214 0.9522
Plasmodium vivax CDK-related protein kinase 6, putative 0.0531 0.6752 1
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0044 0.0482 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0127 0.5564
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0045 0.0137
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0145 0.0951
Echinococcus granulosus neurogenic locus protein delta 0.0008 0.0027 0.0025
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0488 0.0482
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0145 0.0951
Mycobacterium ulcerans glycyl-tRNA synthetase 0.0007 0.001 0.0148
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0116 0.0111
Trichomonas vaginalis CAMK family protein kinase 0.0038 0.0412 0.2695
Entamoeba histolytica hypothetical protein 0.001 0.0041 0.0315
Treponema pallidum prolyl-tRNA synthetase 0.0013 0.009 1
Trypanosoma cruzi glucose transporter, putative 0.0018 0.0145 0.2935
Loa Loa (eye worm) hypothetical protein 0.0008 0.0027 0.0075
Onchocerca volvulus 0.0018 0.0145 0.2726
Loa Loa (eye worm) hypothetical protein 0.0017 0.0139 0.0469
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0048 0.0539 0.1869
Schistosoma mansoni notch 0.0008 0.0027 0.0025
Loa Loa (eye worm) hypothetical protein 0.0018 0.0145 0.049
Schistosoma mansoni laminin gamma-3 chain 0.0008 0.0027 0.0025
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0045 0.0137
Brugia malayi EGF-like domain containing protein 0.0008 0.0027 0.0075
Onchocerca volvulus Bile acid receptor homolog 0.001 0.0045 0.0762
Echinococcus granulosus protein jagged 1 0.0008 0.0027 0.0025
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0041 0.0271
Schistosoma mansoni chromosome transmission fidelity factor 0.001 0.0042 0.0042
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0044 0.0482 1
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0214 0.183
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0045 0.0039
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0038 0.0402 0.263
Echinococcus granulosus protein jagged 2 0.0008 0.0027 0.0025
Leishmania major lysyl-tRNA synthetase, putative 0.0028 0.0278 0.5725
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0488 0.0568
Trichomonas vaginalis antibiotic synthetase, putative 0.0007 0.0006 0.0037
Brugia malayi Cadherin domain containing protein 0.0008 0.0027 0.0075
Echinococcus multilocularis neurogenic locus notch protein 0.0008 0.0027 0.0021
Onchocerca volvulus 0.0018 0.0145 0.2726
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0045 0.0046
Leishmania major hypothetical protein, conserved 0.0018 0.0145 0.2935
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0018 0.0145 0.2935
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0038 0.0412 0.0407
Echinococcus granulosus calcium dependent protein kinase 0.0036 0.0382 0.0443
Loa Loa (eye worm) hypothetical protein 0.001 0.0045 0.0137
Loa Loa (eye worm) histone methyltransferase 0.0009 0.003 0.0084
Loa Loa (eye worm) hypothetical protein 0.0024 0.0232 0.0795
Onchocerca volvulus Neurogenic locus notch protein homolog 0.0008 0.0027 0.0416
Schistosoma mansoni hypothetical protein 0.0008 0.0027 0.0025
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0028 0.0278 0.6881
Onchocerca volvulus 0.0018 0.0145 0.2726
Brugia malayi Doublecortin family protein 0.0019 0.0165 0.0559
Brugia malayi Peroxidasin 0.0026 0.0253 0.0867
Entamoeba histolytica threonyl-tRNA synthetase, putative 0.0007 0.001 0.0036
Loa Loa (eye worm) hypothetical protein 0.0008 0.0027 0.0075
Loa Loa (eye worm) hypothetical protein 0.0018 0.0145 0.049
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0038 0.0412 0.853
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0018 0.0145 1
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0045 0.0039
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0095 0.1143 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.0402 0.139
Schistosoma mansoni hypothetical protein 0.0035 0.0366 0.0425
Plasmodium falciparum calcium-dependent protein kinase 4 0.0038 0.0412 0.0603
Trypanosoma cruzi hypothetical protein, conserved 0.001 0.0041 0.0752
Echinococcus multilocularis solute carrier family 22 0.0018 0.0145 0.014
Entamoeba histolytica hypothetical protein 0.0035 0.0366 0.3171
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0045 0.0046
Schistosoma mansoni tar DNA-binding protein 0.0061 0.071 0.0829
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0038 0.0412 0.0407
Giardia lamblia Lysyl-tRNA synthetase 0.0028 0.0278 0.6849
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0017 0.0139 0.4823
Onchocerca volvulus 0.0008 0.0027 0.0416
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0045 0.0137
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0125 0.1529 0.1524
Plasmodium vivax lysine--tRNA ligase, putative 0.0028 0.0278 0.0404
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0214 0.5251
Echinococcus granulosus survival motor neuron protein 1 0.0228 0.2859 0.336
Loa Loa (eye worm) hypothetical protein 0.0026 0.0253 0.0867
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0145 0.0951
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0145 0.0951
Schistosoma mansoni hypothetical protein 0.0015 0.0115 0.0129
Echinococcus granulosus microtubule associated protein 2 0.0667 0.8498 1
Leishmania major threonyl-tRNA synthetase, putative 0.0007 0.001 0.0085
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0038 0.0412 0.0407
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0045 0.0046
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0418 0.2736
Echinococcus granulosus Sugar transporter ERD6 protein 0.0018 0.0145 0.0165
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0145 0.0951
Loa Loa (eye worm) hypothetical protein 0.0026 0.0253 0.0867
Brugia malayi Major Facilitator Superfamily protein 0.0018 0.0145 0.049
Loa Loa (eye worm) hypothetical protein 0.0018 0.0145 0.049
Onchocerca volvulus Peroxidase homolog 0.0026 0.0253 0.4822
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0041 0.0271
Onchocerca volvulus 0.0026 0.0253 0.4822
Brugia malayi Calcium binding EGF domain containing protein 0.0008 0.0027 0.0075
Loa Loa (eye worm) hypothetical protein 0.0017 0.0139 0.0469
Brugia malayi hypothetical protein 0.0018 0.0145 0.049
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0038 0.0412 0.0912
Schistosoma mansoni notch 0.0008 0.0027 0.0025
Loa Loa (eye worm) hypothetical protein 0.0026 0.0253 0.0867
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0145 0.0951
Plasmodium falciparum lysine--tRNA ligase 0.0028 0.0278 0.0404
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0038 0.0412 0.0479
Echinococcus granulosus RUN 0.0019 0.0165 0.0188
Trypanosoma cruzi hexose transporter, putative 0.0018 0.0145 0.2935
Giardia lamblia Prolyl-tRNA synthetase 0.0038 0.0402 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0165 0.0559
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0045 0.0046
Plasmodium falciparum mitogen-activated protein kinase 2 0.0202 0.2521 0.3728
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0015 0.0115 0.0129
Loa Loa (eye worm) hypothetical protein 0.0026 0.0253 0.0867
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0045 0.0137
Mycobacterium tuberculosis Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase)(ThrRS) (threonine-tRNA ligase) 0.0007 0.001 0.0185
Onchocerca volvulus 0.0008 0.0027 0.0416
Brugia malayi EGF-like domain containing protein 0.0008 0.0027 0.0075
Trypanosoma brucei glycyl-tRNA synthetase, putative 0.0007 0.001 0.0085
Echinococcus multilocularis protein dispatched 1 0.0047 0.0519 0.0513
Brugia malayi EGF-like domain containing protein 0.0008 0.0027 0.0075
Onchocerca volvulus 0.0018 0.0145 0.2726
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0232 0.476
Echinococcus granulosus geminin 0.0164 0.2026 0.2379
Schistosoma mansoni septate junction protein 0.0008 0.0027 0.0025
Echinococcus multilocularis Niemann Pick C1 protein 0.0136 0.1668 0.1664
Loa Loa (eye worm) hypothetical protein 0.0023 0.0214 0.073
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0145 0.0951
Onchocerca volvulus 0.0018 0.0145 0.2726
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0045 0.0046
Mycobacterium ulcerans sugar transporter 0.0018 0.0145 0.5126
Schistosoma mansoni hypothetical protein 0.0039 0.0425 0.0494
Brugia malayi steroid hormone receptor 0.001 0.0045 0.0137
Brugia malayi EGF-like domain containing protein 0.0008 0.0027 0.0075
Trypanosoma cruzi hexose transporter, putative 0.0039 0.0418 0.8662
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.001 0.0045 0.0762
Onchocerca volvulus 0.0023 0.0214 0.4058
Onchocerca volvulus 0.0018 0.0145 0.2726
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0038 0.0402 0.139
Loa Loa (eye worm) hypothetical protein 0.0026 0.0253 0.0867
Echinococcus multilocularis sterol regulatory element binding protein 0.0041 0.0444 0.0439
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0045 0.0137
Onchocerca volvulus 0.0008 0.0027 0.0416
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0045 0.0137
Schistosoma mansoni hypothetical protein 0.0039 0.0425 0.0494
Plasmodium vivax replication factor C subunit 1, putative 0.001 0.0042 0.0053
Loa Loa (eye worm) hypothetical protein 0.0041 0.0444 0.1538
Schistosoma mansoni survival motor neuron protein 0.0047 0.0519 0.0604
Brugia malayi nuclear receptor NHR-88 0.001 0.0045 0.0137
Loa Loa (eye worm) isocitrate dehydrogenase 0.0015 0.0116 0.0388
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0038 0.0402 0.0467
Loa Loa (eye worm) glycyl-tRNA synthetase 0.0007 0.001 0.0014
Toxoplasma gondii lysine-tRNA ligase 0.0028 0.0278 0.0611
Onchocerca volvulus 0.0018 0.0145 0.2726
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0214 0.4369
Loa Loa (eye worm) hypothetical protein 0.0018 0.0145 0.049
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.001 0.0041 0.008
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0044 0.0482 1
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0145 0.0951
Onchocerca volvulus 0.0018 0.0145 0.2726
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0145 0.0951
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.001 0.0042 0.0271
Trichomonas vaginalis antibiotic synthetase, putative 0.0007 0.0006 0.0037
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0145 0.0951
Echinococcus multilocularis replication factor c subunit 1 0.001 0.0042 0.0036
Mycobacterium leprae Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase) (ThrRS) (Threonine-tRNA ligase) 0.0007 0.001 0.0102
Echinococcus multilocularis survival motor neuron protein 1 0.0228 0.2859 0.2855
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0145 0.0951
Schistosoma mansoni peroxidasin 0.0026 0.0253 0.0291
Loa Loa (eye worm) hypothetical protein 0.0018 0.0145 0.049
Schistosoma mansoni hypothetical protein 0.0125 0.1529 0.1794
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0041 0.0271
Loa Loa (eye worm) hypothetical protein 0.0017 0.0139 0.0469
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0024 0.0224 1
Brugia malayi Animal haem peroxidase family protein 0.0026 0.0253 0.0867
Echinococcus granulosus notch 0.0008 0.0027 0.0025
Loa Loa (eye worm) latrophilin receptor protein 2 0.0015 0.0115 0.0384
Trypanosoma cruzi sugar transporter, putative 0.0018 0.0145 0.2935
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0038 0.0412 0.0479
Loa Loa (eye worm) hypothetical protein 0.0026 0.0253 0.0867
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0045 0.0046
Toxoplasma gondii protein kinase, putative 0.0353 0.4468 1
Echinococcus multilocularis geminin 0.0164 0.2026 0.2021
Plasmodium falciparum hexose transporter 0.0125 0.1529 0.2258
Schistosoma mansoni tar DNA-binding protein 0.0061 0.071 0.0829
Schistosoma mansoni hypothetical protein 0.0019 0.0165 0.0188
Plasmodium falciparum LCCL domain-containing protein 0.0019 0.0165 0.0237
Plasmodium vivax acyl-CoA synthetase, putative 0.0017 0.0139 0.0198
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0145 0.0951
Brugia malayi Sugar transporter family protein 0.0018 0.0145 0.049
Trichomonas vaginalis glucose transporter, putative 0.0018 0.0145 0.0951
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.0018 0.0145 0.6395
Echinococcus multilocularis cpg binding protein 0.0029 0.0296 0.0291
Loa Loa (eye worm) hypothetical protein 0.001 0.0041 0.0126
Echinococcus granulosus delta-like protein 1 0.0008 0.0027 0.0025
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0165 0.016
Echinococcus granulosus tar DNA binding protein 0.0061 0.071 0.0829
Loa Loa (eye worm) hypothetical protein 0.0228 0.2859 1
Brugia malayi Animal haem peroxidase family protein 0.0026 0.0253 0.0867
Onchocerca volvulus 0.001 0.0045 0.0762
Trichomonas vaginalis glucose transporter, putative 0.0039 0.0418 0.2736
Schistosoma mansoni notch 0.0008 0.0027 0.0025
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0214 0.183
Echinococcus multilocularis solute carrier family 22 0.0018 0.0145 0.014
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0038 0.0412 0.0912
Trypanosoma cruzi hypothetical protein, conserved 0.001 0.0041 0.0752
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0145 0.0951
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0202 0.2521 0.5636
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0038 0.0402 0.139
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0145 0.0951
Loa Loa (eye worm) hypothetical protein 0.0026 0.0253 0.0867
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0145 0.0951
Brugia malayi TAR-binding protein 0.0061 0.071 0.2468
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0045 0.0046
Mycobacterium ulcerans integral membrane transport protein 0.0018 0.0145 0.5126
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.001 0.0042 0.0271
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0444 0.2906
Schistosoma mansoni hypothetical protein 0.0008 0.0027 0.0025
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0015 0.0116 0.5062
Trypanosoma brucei glucose transporter, putative 0.0039 0.0418 0.8662
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0038 0.0402 0.0397
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0045 0.0137
Loa Loa (eye worm) major facilitator superfamily transporter 0.0018 0.0145 0.049
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0488 0.0568
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0045 0.0046
Trichomonas vaginalis sugar transport protein, putative 0.0018 0.0145 0.0951
Brugia malayi Sugar transporter family protein 0.0018 0.0145 0.049
Trypanosoma brucei glucose transporter, putative 0.0039 0.0418 0.8662
Trypanosoma cruzi hexose transporter, putative 0.0039 0.0418 0.8662
Onchocerca volvulus 0.0018 0.0145 0.2726
Schistosoma mansoni polycystin 1-related 0.0019 0.0165 0.0188
Toxoplasma gondii sugar transporter ST1 0.0018 0.0145 0.0313
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0041 0.0271
Loa Loa (eye worm) hypothetical protein 0.0008 0.0027 0.0075
Echinococcus granulosus sterol regulatory element binding protein 0.0041 0.0444 0.0517
Trypanosoma brucei glucose transporter, putative 0.0039 0.0418 0.8662
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0114 0.1391 0.1386
Onchocerca volvulus 0.0018 0.0145 0.2726
Plasmodium vivax multidomain scavenger receptor, putative 0.0019 0.0165 0.0237
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0145 0.0951
Schistosoma mansoni hypothetical protein 0.0015 0.0115 0.0129
Echinococcus granulosus neurogenic locus notch protein 0.0008 0.0027 0.0025
Loa Loa (eye worm) hypothetical protein 0.001 0.0045 0.0137
Schistosoma mansoni sugar transporter 0.0018 0.0145 0.0165
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.0116 0.2323
Loa Loa (eye worm) hypothetical protein 0.0018 0.0145 0.049
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0045 0.0046
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0045 0.0137
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0145 0.0951
Brugia malayi hypothetical protein 0.0018 0.0145 0.049
Brugia malayi hypothetical protein 0.0035 0.0366 0.1264
Brugia malayi Animal haem peroxidase family protein 0.0026 0.0253 0.0867
Plasmodium vivax calcium-dependent protein kinase, putative 0.0038 0.0412 0.0603
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0038 0.0412 0.1425
Mycobacterium ulcerans threonyl-tRNA synthetase 0.0007 0.001 0.0148
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0214 0.073
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0041 0.0444 0.1538
Loa Loa (eye worm) hypothetical protein 0.0008 0.0027 0.0075
Brugia malayi Cadherin domain containing protein 0.0008 0.0027 0.0075
Loa Loa (eye worm) hypothetical protein 0.001 0.0041 0.0126
Loa Loa (eye worm) hypothetical protein 0.0008 0.0027 0.0075
Plasmodium falciparum replication factor C subunit 1, putative 0.001 0.0042 0.0053
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0045 0.0039
Schistosoma mansoni hypothetical protein 0.0008 0.0027 0.0025
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0015 0.0116 0.2323
Loa Loa (eye worm) animal heme peroxidase 0.0026 0.0253 0.0867
Plasmodium vivax proline--tRNA ligase, putative 0.0044 0.0482 0.0706
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0232 0.476
Toxoplasma gondii isocitrate dehydrogenase 0.0015 0.0116 0.0248
Giardia lamblia High cysteine protein 0.0008 0.0027 0.0441
Schistosoma mansoni glucose transporter 0.0018 0.0145 0.0165
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0145 0.0951
Trypanosoma cruzi FHA domain containing protein, putative 0.001 0.0041 0.0752
Brugia malayi DKFZp564C0469 protein 0.001 0.0041 0.0126
Schistosoma mansoni cpg binding protein 0.0029 0.0296 0.0342
Trichomonas vaginalis sugar transporter, putative 0.0039 0.0418 0.2736
Schistosoma mansoni tar DNA-binding protein 0.0061 0.071 0.0829
Loa Loa (eye worm) hypothetical protein 0.003 0.0312 0.1072
Toxoplasma gondii threonyl-tRNA synthetase family protein 0.0007 0.001 0.0009
Plasmodium vivax ataxin-2 like protein, putative 0.0024 0.0232 0.0336
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0214 0.7631
Schistosoma mansoni nuclear hormone receptor 0.001 0.0045 0.0046
Loa Loa (eye worm) hypothetical protein 0.0018 0.0145 0.049
Loa Loa (eye worm) hypothetical protein 0.0026 0.0253 0.0867
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0028 0.0278 1
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0015 0.0117 0.0392
Brugia malayi hypothetical protein 0.001 0.0041 0.0126
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0145 0.0951
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0017 0.0139 0.49
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0214 0.4369
Brugia malayi CXXC zinc finger family protein 0.0028 0.0276 0.0948
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.0214 0.183
Trypanosoma cruzi BRCA1 C Terminus (BRCT) domain containing protein, putative 0.001 0.0041 0.0752
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0007 0.0008 0.0002
Schistosoma mansoni hypothetical protein 0.0011 0.006 0.0064
Brugia malayi EGF-like domain containing protein 0.0008 0.0027 0.0075
Schistosoma mansoni coup transcription factor 0.001 0.0045 0.0046
Loa Loa (eye worm) hypothetical protein 0.0026 0.0253 0.0867
Trichomonas vaginalis sugar transporter, putative 0.0039 0.0418 0.2736
Onchocerca volvulus Peroxidasin homolog 0.0026 0.0253 0.4822
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0015 0.0115 0.011
Loa Loa (eye worm) Notch2 0.0008 0.0027 0.0075
Plasmodium falciparum acyl-CoA synthetase 0.0017 0.0139 0.0198
Plasmodium falciparum calcium-dependent protein kinase 1 0.0038 0.0412 0.0603
Trypanosoma brucei glucose transporter 1E 0.0039 0.0418 0.8662
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0028 0.0278 0.5725
Echinococcus multilocularis calcium dependent protein kinase 0.0036 0.0382 0.0376
Loa Loa (eye worm) hypothetical protein 0.0008 0.0027 0.0075
Echinococcus multilocularis expressed conserved protein 0.0089 0.1069 0.1064
Trypanosoma brucei glucose transporter, putative 0.0039 0.0418 0.8662
Trypanosoma cruzi hexose transporter, putative 0.0021 0.0192 0.3912
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0114 0.1391 0.1632
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0045 0.0137
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0488 0.0568
Toxoplasma gondii facilitative glucose transporter GT1 0.0125 0.1529 0.3414
Onchocerca volvulus 0.0018 0.0145 0.2726
Loa Loa (eye worm) hypothetical protein 0.001 0.0045 0.0137
Loa Loa (eye worm) hypothetical protein 0.001 0.0045 0.0137
Trichomonas vaginalis replication factor C large subunit, putative 0.001 0.0042 0.0271
Schistosoma mansoni topbp1 0.001 0.0041 0.0042
Onchocerca volvulus 0.0028 0.0276 0.5272
Loa Loa (eye worm) hypothetical protein 0.0017 0.0139 0.0469
Toxoplasma gondii isocitrate dehydrogenase 0.0015 0.0116 0.0248
Brugia malayi hypothetical protein 0.001 0.0041 0.0126
Loa Loa (eye worm) hypothetical protein 0.0018 0.0145 0.049
Loa Loa (eye worm) hypothetical protein 0.0038 0.0402 0.139
Schistosoma mansoni hypothetical protein 0.0164 0.2026 0.2379
Leishmania major hypothetical protein, conserved 0.0024 0.0232 0.476
Mycobacterium ulcerans prolyl-tRNA synthetase 0.0013 0.009 0.3082
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0214 0.073
Loa Loa (eye worm) notch protein 0.0008 0.0027 0.0075
Leishmania major glucose transporter, lmgt3 0.0039 0.0418 0.8662
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0125 0.1529 0.1794
Brugia malayi isocitrate dehydrogenase 0.0015 0.0116 0.0388
Onchocerca volvulus 0.0019 0.0165 0.311
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.0007 0.001 0.0085
Echinococcus multilocularis synaptic vesicle 2 protein 0.0018 0.0145 0.014
Trypanosoma cruzi hexose transporter 0.0039 0.0418 0.8662
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0045 0.0046
Echinococcus multilocularis Threonyl tRNA synthetase, C 0.0007 0.001 0.0004
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0214 0.5251
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0488 0.0568
Loa Loa (eye worm) hypothetical protein 0.0018 0.0145 0.049
Loa Loa (eye worm) hypothetical protein 0.001 0.0045 0.0137
Loa Loa (eye worm) hypothetical protein 0.0008 0.0027 0.0075
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0045 0.0039
Plasmodium vivax glycine--tRNA ligase, putative 0.0007 0.001 0.0006
Schistosoma mansoni lysyl-tRNA synthetase 0.0028 0.0278 0.0321
Loa Loa (eye worm) hypothetical protein 0.0018 0.0145 0.049
Schistosoma mansoni cpg binding protein 0.0028 0.0276 0.0319
Plasmodium falciparum calcium-dependent protein kinase 2 0.0038 0.0412 0.0603
Schistosoma mansoni hypothetical protein 0.0164 0.2026 0.2379
Loa Loa (eye worm) hypothetical protein 0.0008 0.0027 0.0075
Brugia malayi notch-like transmembrane receptor 0.0008 0.0027 0.0075
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0045 0.0137
Echinococcus granulosus FTZ F1 alpha 0.001 0.0045 0.0046
Schistosoma mansoni sugar transporter 0.0018 0.0145 0.0165
Leishmania major glucose transporter, lmgt1 0.0039 0.0418 0.8662
Loa Loa (eye worm) hypothetical protein 0.0017 0.0139 0.0469
Entamoeba histolytica protein kinase, putative 0.0038 0.0412 0.3574
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0045 0.0046
Leishmania major protein kinase, putative 0.0038 0.0412 0.853
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0045 0.0039
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0015 0.0116 0.0164
Schistosoma mansoni rab6-interacting 0.0019 0.0165 0.0188
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0038 0.0402 0.3486
Loa Loa (eye worm) sugar transporter 0.0125 0.1529 0.534
Giardia lamblia Replication factor C, subunit 1 0.001 0.0042 0.0811
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0024 0.0234 0.1531
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0125 0.1529 0.1794
Brugia malayi Calcitonin receptor-like protein seb-1 0.0048 0.0539 0.1869
Toxoplasma gondii glycyl-tRNA synthetase 0.0007 0.001 0.0009
Brugia malayi probable proline-trna synthetase - fission yeast, putative 0.0007 0.001 0.0014
Brugia malayi GCC2 and GCC3 family protein 0.0008 0.0027 0.0075
Loa Loa (eye worm) hypothetical protein 0.0008 0.0027 0.0075
Schistosoma mansoni microtubule-associated protein tau 0.0667 0.8498 1
Schistosoma mansoni slit 0.0008 0.0027 0.0025
Brugia malayi hypothetical protein 0.0018 0.0145 0.049
Echinococcus multilocularis peroxidasin 0.0026 0.0253 0.0248
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0366 0.0425
Brugia malayi Delta serrate ligand family protein 0.0008 0.0027 0.0075
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0045 0.0137
Schistosoma mansoni glucose transport protein 0.0125 0.1529 0.1794
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.001 0.0041 0.0271
Echinococcus granulosus solute carrier family 22 0.0018 0.0145 0.0165
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0045 0.0046
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0045 0.0137
Echinococcus multilocularis fibropellin Ia 0.0008 0.0027 0.0021
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0015 0.0116 0.0164
Brugia malayi EGF-like domain containing protein 0.0008 0.0027 0.0075
Toxoplasma gondii LsmAD domain-containing protein 0.0024 0.0232 0.0508
Schistosoma mansoni protein kinase 0.0038 0.0412 0.0479
Schistosoma mansoni glycyl-tRNA synthetase 0.0007 0.001 0.0005
Onchocerca volvulus 0.0018 0.0145 0.2726
Loa Loa (eye worm) hypothetical protein 0.0008 0.0027 0.0075
Loa Loa (eye worm) hypothetical protein 0.001 0.0045 0.0137
Loa Loa (eye worm) hypothetical protein 0.0019 0.0165 0.0559
Loa Loa (eye worm) hypothetical protein 0.0008 0.0027 0.0075
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0045 0.0137
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.003 0.0028
Brugia malayi Isocitrate dehydrogenase 0.0015 0.0116 0.0388
Schistosoma mansoni hypothetical protein 0.0008 0.0027 0.0025
Schistosoma mansoni hypothetical protein 0.0039 0.0425 0.0494
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0488 0.0482
Schistosoma mansoni topbp1 0.001 0.0041 0.0042
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0145 0.0951
Schistosoma mansoni Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] 0.0008 0.0027 0.0025
Echinococcus multilocularis neurogenic locus protein delta 0.0008 0.0027 0.0021
Schistosoma mansoni DNA ligase IV 0.001 0.0041 0.0042
Schistosoma mansoni hypothetical protein 0.0015 0.0115 0.0129
Loa Loa (eye worm) hypothetical protein 0.001 0.0041 0.0126
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0125 0.1529 0.1794
Trypanosoma brucei glucose transporter, putative 0.0039 0.0418 0.8662
Loa Loa (eye worm) threonyl-tRNA synthetase 0.0007 0.001 0.0014
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0044 0.0482 0.1068
Toxoplasma gondii transporter, major facilitator family protein 0.0018 0.0145 0.0313
Brugia malayi Blistered cuticle protein 3 0.0026 0.0253 0.0867
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0214 0.073
Echinococcus granulosus replication factor c subunit 1 0.001 0.0042 0.0042
Plasmodium vivax hexose transporter 0.0125 0.1529 0.2258
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0044 0.0488 0.169
Entamoeba histolytica hypothetical protein 0.0035 0.0366 0.3171
Echinococcus granulosus glycyl tRNA synthetase 0.0007 0.001 0.0005
Onchocerca volvulus Neurogenic locus notch homolog 0.0008 0.0027 0.0416
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0145 0.0951
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0343 0.1182
Trypanosoma brucei glucose transporter 2A 0.0039 0.0418 0.8662
Loa Loa (eye worm) hypothetical protein 0.001 0.0041 0.0126
Loa Loa (eye worm) major facilitator superfamily transporter 0.0018 0.0145 0.049
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0145 0.0951
Echinococcus granulosus solute carrier family 22 0.0018 0.0145 0.0165
Onchocerca volvulus Slit protein homolog 0.0008 0.0027 0.0416
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.0214 0.7631
Loa Loa (eye worm) hypothetical protein 0.0095 0.1143 0.3986
Loa Loa (eye worm) RNA binding protein 0.0061 0.071 0.2468
Brugia malayi topoisomerase 0.001 0.0041 0.0126
Brugia malayi Calcium binding EGF domain containing protein 0.0008 0.0027 0.0075
Loa Loa (eye worm) hypothetical protein 0.0023 0.0214 0.073
Brugia malayi major facilitator superfamily protein 0.0018 0.0145 0.049
Schistosoma mansoni sugar transporter 0.0018 0.0145 0.0165
Leishmania major glucose transporter, lmgt2 0.0039 0.0418 0.8662
Echinococcus granulosus mixed lineage leukemia protein mll 0.0007 0.0008 0.0003
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0045 0.0137
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0145 0.0951
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0045 0.0039
Loa Loa (eye worm) hypothetical protein 0.0033 0.0343 0.1182
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0145 0.0951
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0214 0.7631
Trypanosoma brucei glucose transporter, putative 0.0039 0.0418 0.8662
Loa Loa (eye worm) hypothetical protein 0.0008 0.0027 0.0075
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0044 0.0482 1
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.003 0.0024
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0127 0.5564
Echinococcus granulosus protein jagged 1 0.0008 0.0027 0.0025
Brugia malayi RNA binding protein 0.0061 0.071 0.2468
Echinococcus multilocularis solute carrier family 22 0.0018 0.0145 0.014
Echinococcus multilocularis isocitrate dehydrogenase 0.0015 0.0116 0.0111
Onchocerca volvulus 0.0008 0.0027 0.0416
Onchocerca volvulus 0.0026 0.0253 0.4822
Brugia malayi lysyl-tRNA synthetase 0.0028 0.0278 0.0956
Echinococcus granulosus lysyl tRNA synthetase 0.0028 0.0278 0.0321
Trichomonas vaginalis conserved hypothetical protein 0.0125 0.1529 1
Mycobacterium ulcerans NAD-dependent DNA ligase LigA 0.001 0.0041 0.1314
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0017 0.0139 0.6114
Loa Loa (eye worm) hypothetical protein 0.0008 0.0027 0.0075
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0018 0.0145 0.014
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0015 0.0115 0.0384
Echinococcus multilocularis protein patched 0.0041 0.0444 0.0439
Echinococcus multilocularis neurogenic locus notch protein 0.0008 0.0027 0.0021
Plasmodium falciparum threonine--tRNA ligase 0.0007 0.001 0.0006
Echinococcus multilocularis nibrin 0.001 0.0041 0.0036
Loa Loa (eye worm) hypothetical protein 0.0018 0.0145 0.049
Schistosoma mansoni cell polarity protein 0.0008 0.0027 0.0025
Brugia malayi hypothetical protein 0.0228 0.2859 1
Brugia malayi hypothetical protein 0.0024 0.0232 0.0795
Loa Loa (eye worm) hypothetical protein 0.0028 0.0278 0.0956
Schistosoma mansoni notch 0.0008 0.0027 0.0025
Brugia malayi EGF-like domain containing protein 0.0008 0.0027 0.0075
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0145 0.0951
Toxoplasma gondii sugar transporter ST3 0.0018 0.0145 0.0313
Schistosoma mansoni hypothetical protein 0.0395 0.5004 0.5886
Echinococcus granulosus neurogenic locus notch protein 0.0008 0.0027 0.0025
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0028 0.0278 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0045 0.0137
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0145 0.0951
Echinococcus granulosus Threonyl tRNA synthetase C 0.0007 0.001 0.0005
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0145 0.0951
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0145 0.0951
Entamoeba histolytica protein kinase, putative 0.0038 0.0412 0.3574
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0045 0.0039
Echinococcus granulosus cpg binding protein 0.0029 0.0296 0.0342
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0165 0.0188
Echinococcus granulosus slit 2 protein 0.0008 0.0027 0.0025
Brugia malayi nuclear hormone receptor 0.001 0.0045 0.0137
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0038 0.0412 0.1425
Onchocerca volvulus 0.0019 0.0165 0.311
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.0214 0.7631
Schistosoma mansoni thyroid hormone receptor 0.001 0.0045 0.0046
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0488 0.0568
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0044 0.0482 1
Onchocerca volvulus Chorion peroxidase homolog 0.0026 0.0253 0.4822
Loa Loa (eye worm) hypothetical protein 0.0018 0.0145 0.049
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0045 0.0137
Schistosoma mansoni tar DNA-binding protein 0.0061 0.071 0.0829
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0145 0.0951
Brugia malayi hypothetical protein 0.0019 0.0165 0.0559
Trypanosoma cruzi hexose transporter, putative 0.0039 0.0418 0.8662
Echinococcus granulosus Niemann Pick C1 protein 0.0095 0.1143 0.1339
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0038 0.0402 1
Echinococcus multilocularis Polycystic kidney disease protein 0.0019 0.0165 0.016
Loa Loa (eye worm) hypothetical protein 0.0023 0.0214 0.073
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0045 0.0039
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0045 0.0039
Echinococcus multilocularis RUN 0.0019 0.0165 0.016
Schistosoma mansoni hypothetical protein 0.0008 0.0027 0.0025
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0038 0.0412 0.1425
Trypanosoma brucei PAB1-binding protein , putative 0.0024 0.0232 0.476
Echinococcus granulosus solute carrier family 22 0.0018 0.0145 0.0165
Onchocerca volvulus Peroxidasin homolog 0.0026 0.0253 0.4822
Brugia malayi threonyl-tRNA synthetase, cytoplasmic 0.0007 0.001 0.0014
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0007 0.0008 0.0003
Brugia malayi Calcium binding EGF domain containing protein 0.0008 0.0027 0.0075
Loa Loa (eye worm) hypothetical protein 0.0008 0.0027 0.0075
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.001 0.0041 0.0271
Onchocerca volvulus Dual oxidase homolog 0.0026 0.0253 0.4822
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0015 0.0115 0.0129
Loa Loa (eye worm) hypothetical protein 0.0008 0.0027 0.0075
Echinococcus multilocularis General substrate transporter 0.0108 0.1303 0.1298
Echinococcus multilocularis neural cadherin 0.0008 0.0027 0.0021
Echinococcus granulosus dnaJ subfamily B 0.0395 0.5004 0.5886
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0145 0.0951
Echinococcus multilocularis notch 0.0008 0.0027 0.0021
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0145 0.0951
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0015 0.0115 0.011
Onchocerca volvulus 0.0008 0.0027 0.0416
Echinococcus granulosus Protein patched homolog 1 0.0041 0.0444 0.0517
Loa Loa (eye worm) hypothetical protein 0.001 0.0041 0.0126
Loa Loa (eye worm) hypothetical protein 0.0008 0.0027 0.0075
Loa Loa (eye worm) hypothetical protein 0.001 0.0045 0.0137
Loa Loa (eye worm) hypothetical protein 0.0018 0.0145 0.049
Brugia malayi CHE-14 protein 0.0041 0.0444 0.1538
Loa Loa (eye worm) hypothetical protein 0.0008 0.0027 0.0075
Schistosoma mansoni rab6-interacting 0.0019 0.0165 0.0188
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0018 0.0145 0.0165
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0045 0.0046
Brugia malayi Major Facilitator Superfamily protein 0.0018 0.0145 0.049
Trypanosoma brucei THT1 - hexose transporter, putative 0.0039 0.0418 0.8662
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0125 0.1529 0.1794
Echinococcus multilocularis tar DNA binding protein 0.0061 0.071 0.0705
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0038 0.0412 0.0479
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0145 0.0951
Leishmania major myo-inositol/proton symporter (MIT) 0.0018 0.0145 0.2935
Brugia malayi Animal haem peroxidase family protein 0.0026 0.0253 0.0867
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0125 0.1529 0.1524
Plasmodium falciparum proline--tRNA ligase 0.0044 0.0482 0.0706
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0045 0.0046
Loa Loa (eye worm) hypothetical protein 0.0018 0.0145 0.049
Echinococcus granulosus Niemann Pick C1 protein 0.0136 0.1668 0.1958
Loa Loa (eye worm) doublecortin family protein 0.0019 0.0165 0.0559
Toxoplasma gondii histone lysine methyltransferase SET1 0.0053 0.0596 0.1322
Schistosoma mansoni tar DNA-binding protein 0.0061 0.071 0.0829
Echinococcus multilocularis GPCR, family 2 0.0015 0.0115 0.011
Trypanosoma brucei THT1 - hexose transporter, putative 0.0039 0.0418 0.8662
Toxoplasma gondii EGF family domain-containing protein 0.0008 0.0027 0.0048
Onchocerca volvulus 0.001 0.0041 0.0699
Loa Loa (eye worm) hypothetical protein 0.0008 0.0027 0.0075
Echinococcus multilocularis fat cadherin tumor suppressor 0.0008 0.0027 0.0021
Plasmodium falciparum calcium-dependent protein kinase 5 0.0038 0.0412 0.0603
Echinococcus multilocularis neurogenic locus notch protein 4 0.0008 0.0027 0.0021
Brugia malayi Latrophilin receptor protein 2 0.0015 0.0115 0.0384
Toxoplasma gondii ATPase, AAA family protein 0.001 0.0042 0.008
Schistosoma mansoni loxhd1 0.0019 0.0165 0.0188
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0366 0.0361
Loa Loa (eye worm) blistered cuticle protein 3 0.0026 0.0253 0.0867
Schistosoma mansoni glucose transport protein 0.0125 0.1529 0.1794
Entamoeba histolytica glycyl-tRNA synthetase, putative 0.0007 0.001 0.0036
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0145 0.0951
Echinococcus granulosus neural cadherin 0.0008 0.0027 0.0025
Loa Loa (eye worm) hypothetical protein 0.0026 0.0253 0.0867
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0097 0.1162 0.1362
Echinococcus multilocularis dnaJ subfamily B 0.0395 0.5004 0.5001
Echinococcus multilocularis slit 2 protein 0.0008 0.0027 0.0021
Echinococcus multilocularis microtubule associated protein 2 0.0667 0.8498 0.8497
Echinococcus granulosus General substrate transporter 0.0108 0.1303 0.1527
Brugia malayi Major Facilitator Superfamily protein 0.0018 0.0145 0.049
Schistosoma mansoni lipoxygenase 0.008 0.0948 0.111
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0145 0.0951
Schistosoma mansoni lysyl-tRNA synthetase 0.0028 0.0278 0.0321
Echinococcus granulosus solute carrier family 22 0.0018 0.0145 0.0165
Onchocerca volvulus Putative transporter 0.0018 0.0145 0.2726
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0045 0.0137
Loa Loa (eye worm) hypothetical protein 0.0048 0.0539 0.1869
Echinococcus granulosus peroxidasin 0.0026 0.0253 0.0291
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0038 0.0412 0.0912
Echinococcus granulosus protein jagged 2 0.0008 0.0027 0.0025
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.0116 0.2323
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0519 0.1798
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0011 0.006 0.0054
Chlamydia trachomatis lysine--tRNA ligase 0.0028 0.0278 1
Brugia malayi Animal haem peroxidase family protein 0.0026 0.0253 0.0867
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0059 0.0676 0.079
Entamoeba histolytica hypothetical protein 0.0035 0.0366 0.3171
Trypanosoma brucei THT1 - hexose transporter, putative 0.0039 0.0418 0.8662
Schistosoma mansoni hypothetical protein 0.0015 0.0115 0.0129
Brugia malayi Pax transcription activation domain interacting protein 0.001 0.0041 0.0126
Echinococcus multilocularis protein jagged 1 0.0008 0.0027 0.0021
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0127 0.5564
Plasmodium vivax sugar transporter, putative 0.0018 0.0145 0.0207
Chlamydia trachomatis proline--tRNA ligase 0.0013 0.009 0.2978
Trichomonas vaginalis threonyl-tRNA synthetase, putative 0.0007 0.001 0.0063
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0038 0.0412 0.0603
Toxoplasma gondii sugar transporter ST2 0.0018 0.0145 0.0313
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0116 0.0111
Onchocerca volvulus 0.0018 0.0145 0.2726
Brugia malayi ecdysteroid receptor 0.001 0.0045 0.0137
Schistosoma mansoni hypothetical protein 0.0039 0.0425 0.0494
Brugia malayi major facilitator superfamily protein 0.0018 0.0145 0.049
Mycobacterium ulcerans hypothetical protein 0.0023 0.0214 0.7631
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0045 0.0137
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0038 0.0402 0.0467
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0018 0.0145 0.5126
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0041 0.0271
Mycobacterium leprae PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+]) 0.001 0.0041 0.0904
Echinococcus multilocularis glycyl tRNA synthetase 0.0007 0.001 0.0004
Brugia malayi Muscle positioning protein 4 0.0008 0.0027 0.0075
Brugia malayi hypothetical protein 0.0026 0.0253 0.0867
Brugia malayi F/Y-rich N-terminus family protein 0.0008 0.0028 0.0079
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0028 0.0278 0.5725
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0008 0.0027 0.0075
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0045 0.0137
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0165 0.0188
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0214 0.9522
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0018 0.0145 0.6395
Wolbachia endosymbiont of Brugia malayi NAD-dependent DNA ligase, Lig 0.001 0.0041 0.2343
Loa Loa (eye worm) hypothetical protein 0.0026 0.0253 0.0867
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0038 0.0412 0.0407
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0061 0.071 0.2468
Loa Loa (eye worm) animal heme peroxidase 0.0026 0.0253 0.0867
Plasmodium falciparum calcium-dependent protein kinase 3 0.0038 0.0412 0.0603
Brugia malayi hypothetical protein 0.0019 0.0165 0.0559
Schistosoma mansoni patched 1 0.0041 0.0444 0.0517
Loa Loa (eye worm) animal heme peroxidase 0.0026 0.0253 0.0867
Entamoeba histolytica hypothetical protein 0.0028 0.0278 0.2399
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.001 0.0041 0.0126
Schistosoma mansoni thyroid hormone receptor 0.001 0.0045 0.0046
Echinococcus granulosus GPCR family 2 0.0015 0.0115 0.0129
Schistosoma mansoni hypothetical protein 0.0033 0.0343 0.0397
Schistosoma mansoni cpg binding protein 0.0029 0.0296 0.0342
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0015 0.0116 0.2323
Trypanosoma brucei threonyl-tRNA synthetase, putative 0.0007 0.001 0.0085
Loa Loa (eye worm) hypothetical protein 0.0015 0.0115 0.0384
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0214 0.7631
Trichomonas vaginalis myo-inositol transporter, putative 0.0018 0.0145 0.0951
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0038 0.0412 0.0603
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0045 0.0137
Echinococcus granulosus fibropellin Ia 0.0008 0.0027 0.0025
Brugia malayi hypothetical protein 0.0016 0.0121 0.0406
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0202 0.2521 0.3728
Onchocerca volvulus 0.0047 0.0519 1
Onchocerca volvulus 0.0026 0.0253 0.4822
Onchocerca volvulus Peroxidase homolog 0.0026 0.0253 0.4822
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0165 0.016
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0366 0.0425
Schistosoma mansoni lipoxygenase 0.0114 0.1391 0.1632
Loa Loa (eye worm) hypothetical protein 0.005 0.0563 0.1952
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.0007 0.001 0.0085
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0418 0.2736
Trypanosoma brucei glucose transporter, putative 0.0039 0.0418 0.8662
Onchocerca volvulus 0.0018 0.0145 0.2726
Schistosoma mansoni hypothetical protein 0.0008 0.0027 0.0025
Brugia malayi glycyl-tRNA synthetase 0.0007 0.001 0.0014
Giardia lamblia Sugar-proton symporter 0.0018 0.0145 0.346
Echinococcus granulosus Polycystic kidney disease protein 0.0019 0.0165 0.0188
Leishmania major glucose transporter/membrane transporter D2, putative 0.0039 0.0418 0.8662
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0015 0.0116 0.013
Chlamydia trachomatis DNA ligase 0.001 0.0041 0.1184
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0125 0.1529 0.1524
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0232 0.0336
Schistosoma mansoni hypothetical protein 0.0008 0.0027 0.0025
Plasmodium vivax threonine--tRNA ligase, putative 0.0007 0.001 0.0006
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0015 0.0116 0.0111
Loa Loa (eye worm) hypothetical protein 0.0008 0.0027 0.0075
Brugia malayi RNA recognition motif domain containing protein 0.0061 0.071 0.2468
Schistosoma mansoni protein kinase 0.0038 0.0412 0.0479
Loa Loa (eye worm) animal heme peroxidase 0.0026 0.0253 0.0867
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0145 0.0951
Echinococcus granulosus expressed conserved protein 0.0089 0.1069 0.1252
Loa Loa (eye worm) hypothetical protein 0.0026 0.0253 0.0867
Echinococcus granulosus neurogenic locus notch protein 4 0.0008 0.0027 0.0025
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0007 0.0008 0.0003
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0011 0.006 0.0064
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.001 0.0042 0.0315
Onchocerca volvulus Putative cubilin 0.0008 0.0027 0.0416
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0024 0.0224 1
Brugia malayi Cam kinase protein 1 0.0038 0.0412 0.1425
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0127 0.5564
Loa Loa (eye worm) hypothetical protein 0.0026 0.0253 0.0867
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0038 0.0412 0.0479
Loa Loa (eye worm) hypothetical protein 0.0038 0.0412 0.1425
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0145 0.0951
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0044 0.0488 0.169
Schistosoma mansoni peroxidasin 0.0026 0.0253 0.0291
Giardia lamblia Hexose transporter 0.0018 0.0145 0.346
Echinococcus multilocularis Niemann Pick C1 protein 0.0095 0.1143 0.1138
Brugia malayi Sugar transporter family protein 0.0125 0.1529 0.534
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0145 0.0951
Echinococcus multilocularis protein jagged 1 0.0008 0.0027 0.0021

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) < 0.1 ug ml-1 Cytotoxicity against mouse P388 cells ChEMBL. 8133301

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Mus musculus ChEMBL23 8133301

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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