TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 496.923 | Formula: C27H18ClFN6O
H donors: 3 H acceptors: 2 LogP: 5.6 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: Fc1ccc(c(c1)c1nc2c([nH]1)cc(cc2)c1nc2c([nH]1)ccc(c2)C(=N)N)Oc1ccc(cc1)Cl
InChi: 1S/C27H18ClFN6O/c28-16-3-6-18(7-4-16)36-24-10-5-17(29)13-19(24)27-33-21-9-2-15(12-23(21)35-27)26-32-20-8-1-14(25(30)31)11-22(20)34-26/h1-13H,(H3,30,31)(H,32,34)(H,33,35)
InChiKey: HRHNSDAAODYVBQ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	Tubulin beta 2C chain	0.0583164	1	1
Echinococcus granulosus	beta tubulin	0.0583164	1	1
Loa Loa (eye worm)	beta-tubulin	0.0583164	1	1
Leishmania major	beta tubulin	0.0583164	1	1
Echinococcus granulosus	tubulin alpha 3 chain	0.0405648	0.677163	0.677163
Giardia lamblia	Delta tubulin	0.0130785	0.177286	0.132034
Leishmania major	gamma-tubulin	0.0301219	0.487242	0.486984
Trichomonas vaginalis	tubulin beta chain, putative	0.0405648	0.677163	0.677001
Echinococcus granulosus	Tubulin beta 2C chain	0.0583164	1	1
Trichomonas vaginalis	tubulin gamma chain, putative	0.0301219	0.487242	0.486984
Trichomonas vaginalis	tubulin, putative	0.0170433	0.24939	0.249013
Echinococcus granulosus	death domain containing protein	0.012256	0.162327	0.162327
Trichomonas vaginalis	tubulin beta chain, putative	0.0405648	0.677163	0.677001
Entamoeba histolytica	tubulin alpha chain, putative	0.0405648	0.677163	0.677001
Trypanosoma brucei	alpha tubulin, putative	0.0170433	0.24939	0.207684
Trichomonas vaginalis	tubulin alpha chain, putative	0.0170433	0.24939	0.249013
Brugia malayi	Protein kinase domain containing protein	0.012287	0.162891	0.16247
Echinococcus granulosus	Tubulin alpha 1 chain	0.0405648	0.677163	0.677163
Echinococcus granulosus	multidrug resistance protein 1	0.00335795	0.000502759	0.000502759
Schistosoma mansoni	tubulin subunit alpha	0.0405648	0.677163	0.677001
Trypanosoma brucei	alpha tubulin	0.0405648	0.677163	0.659225
Leishmania major	beta tubulin	0.0583164	1	1
Brugia malayi	Uncoordinated protein 44	0.012256	0.162327	0.161906
Loa Loa (eye worm)	hypothetical protein	0.0274863	0.439311	0.439311
Echinococcus granulosus	alpha tubulin	0.0405648	0.677163	0.677163
Brugia malayi	Low molecular weight phosphotyrosine protein phosphatase containing protein	0.0548778	0.937464	0.937433
Echinococcus multilocularis	tubulin alpha chain	0.0405648	0.677163	0.677163
Leishmania major	beta tubulin	0.0583164	1	1
Echinococcus granulosus	beta tubulin	0.0583164	1	1
Toxoplasma gondii	beta tubulin	0.0583164	1	1
Leishmania major	beta tubulin	0.0583164	1	1
Entamoeba histolytica	tubulin family protein	0.0583164	1	1
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0130785	0.177286	0.176872
Echinococcus multilocularis	tubulin gamma 1 chain	0.0301219	0.487242	0.487242
Echinococcus multilocularis	peroxisome assembly protein 26	0.0405648	0.677163	0.677163
Schistosoma mansoni	tubulin subunit gamma	0.0301219	0.487242	0.486984
Trichomonas vaginalis	tubulin alpha chain, putative	0.0170433	0.24939	0.249013
Trypanosoma cruzi	zeta tubulin, putative	0.0130785	0.177286	0.131573
Echinococcus granulosus	netrin receptor unc 5	0.012256	0.162327	0.162327
Toxoplasma gondii	fructose-1,6-bisphosphate aldolase	0.010081	0.122771	0.12233
Trichomonas vaginalis	tubulin gamma chain, putative	0.0301219	0.487242	0.486984
Schistosoma mansoni	tubulin subunit beta	0.0583164	1	1
Echinococcus granulosus	multidrug resistance protein 1	0.00335795	0.000502759	0.000502759
Echinococcus multilocularis	beta tubulin	0.0583164	1	1
Schistosoma mansoni	tubulin subunit alpha	0.0130785	0.177286	0.176872
Echinococcus granulosus	fructose 16 bisphosphate aldolase	0.010081	0.122771	0.122771
Echinococcus multilocularis	tubulin alpha 1C chain	0.0405648	0.677163	0.677163
Echinococcus multilocularis	tubulin delta chain	0.0130785	0.177286	0.177286
Mycobacterium ulcerans	cell division protein FtsZ	0.0130785	0.177286	0.140872
Trichomonas vaginalis	low molecular weight protein-tyrosine-phosphatase, putative	0.0548778	0.937464	0.937433
Echinococcus multilocularis	fructose 1,6 bisphosphate aldolase	0.010081	0.122771	0.122771
Loa Loa (eye worm)	alpha-tubulin	0.0405648	0.677163	0.677163
Loa Loa (eye worm)	alpha-tubulin	0.0405648	0.677163	0.677163
Trichomonas vaginalis	tubulin alpha chain, putative	0.0170433	0.24939	0.249013
Onchocerca volvulus		0.0548778	0.937464	1
Leishmania major	beta tubulin	0.0583164	1	1
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0170433	0.24939	0.249013
Echinococcus granulosus	fructose 16 bisphosphate aldolase	0.010081	0.122771	0.122771
Schistosoma mansoni	tubulin subunit beta	0.0583164	1	1
Mycobacterium ulcerans	flavin-containing monoamine oxidase AofH	0.0292179	0.470803	0.472596
Loa Loa (eye worm)	hypothetical protein	0.00335795	0.000502759	0.000502759
Echinococcus granulosus	peroxisome assembly protein 26	0.0405648	0.677163	0.677163
Leishmania major	alpha tubulin	0.0405648	0.677163	0.677001
Leishmania major	alpha tubulin	0.0405648	0.677163	0.677001
Trypanosoma brucei	epsilon tubulin	0.0301219	0.487242	0.458752
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0583164	1	1
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.00335795	0.000502759	0.000502759
Loa Loa (eye worm)	hypothetical protein	0.0405648	0.677163	0.677163
Trypanosoma brucei	zeta tubulin	0.0130785	0.177286	0.131573
Plasmodium vivax	tubulin alpha chain, putative	0.0405648	0.677163	0.677001
Entamoeba histolytica	tubulin alpha-1 chain	0.0405648	0.677163	0.677001
Loa Loa (eye worm)	hypothetical protein	0.012256	0.162327	0.162327
Schistosoma mansoni	netrin receptor unc5	0.012256	0.162327	0.161906
Schistosoma mansoni	tubulin subunit delta	0.0130785	0.177286	0.176872
Leishmania major	alpha tubulin	0.0405648	0.677163	0.677001
Leishmania major	alpha tubulin	0.0405648	0.677163	0.677001
Mycobacterium leprae	cell division protein FtsZ	0.0130785	0.177286	0.5
Leishmania major	alpha tubulin	0.0405648	0.677163	0.677001
Toxoplasma gondii	tubulin/FtsZ family, GTPase domain-containing protein	0.0301219	0.487242	0.486984
Trichomonas vaginalis	tubulin beta chain, putative	0.0170433	0.24939	0.249013
Entamoeba histolytica	protein tyrosine phosphatase, putative	0.0548778	0.937464	0.937433
Loa Loa (eye worm)	BEN-1 protein	0.0583164	1	1
Mycobacterium tuberculosis	Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase)	0.0548778	0.937464	1
Echinococcus multilocularis	fructose bisphosphate aldolase class I	0.010081	0.122771	0.122771
Trypanosoma cruzi	beta tubulin, putative	0.0583164	1	1
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	0.00335795	0.000502759	0.000502759
Echinococcus granulosus	Tubulin beta 2C chain	0.0583164	1	1
Plasmodium vivax	tubulin beta chain, putative	0.0583164	1	1
Loa Loa (eye worm)	tubulin alpha 2	0.010443	0.129354	0.129354
Brugia malayi	beta-tubulin, identical	0.0583164	1	1
Echinococcus granulosus	ankyrin repeat and death domain containing protein	0.012256	0.162327	0.162327
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.0548778	0.937464	0.937433
Trypanosoma brucei	beta tubulin	0.0583164	1	1
Echinococcus multilocularis	Tubulin beta 2C chain	0.0583164	1	1
Schistosoma mansoni	alpha tubulin	0.0405648	0.677163	0.677001
Echinococcus multilocularis	multidrug resistance protein 1	0.00335795	0.000502759	0.000502759
Loa Loa (eye worm)	tubulin beta chain	0.0130785	0.177286	0.177286
Echinococcus granulosus	tubulin alpha chain	0.0405648	0.677163	0.677163
Trichomonas vaginalis	tubulin beta-1 chain, putative	0.0130785	0.177286	0.176872
Loa Loa (eye worm)	tubulin alpha 2	0.0274863	0.439311	0.439311
Loa Loa (eye worm)	tubulin alpha chain	0.0405648	0.677163	0.677163
Echinococcus multilocularis	tubulin subunit TubB	0.0405648	0.677163	0.677163
Trypanosoma brucei	fructose-bisphosphate aldolase, glycosomal, putative	0.010081	0.122771	0.074029
Trypanosoma brucei	tubulin delta chain	0.0130785	0.177286	0.131573
Trypanosoma brucei	alpha tubulin	0.0405648	0.677163	0.659225
Trypanosoma cruzi	alpha tubulin, putative	0.0405648	0.677163	0.659225
Leishmania major	beta tubulin	0.0583164	1	1
Echinococcus granulosus	tubulin alpha chain	0.0405648	0.677163	0.677163
Trypanosoma brucei	beta tubulin	0.0583164	1	1
Mycobacterium tuberculosis	Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO)	0.0271603	0.433383	0.462004
Plasmodium vivax	cyclin dependent kinase 7 (cdk7), putative	0.0160042	0.230493	0.230106
Treponema pallidum	cell division protein FtsZ	0.0130785	0.177286	0.5
Leishmania major	beta tubulin	0.0583164	1	1
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0405648	0.677163	0.677163
Leishmania major	ATP-binding cassette protein subfamily G, member 6, putative	0.00622469	0.0526385	0.052162
Trypanosoma cruzi	epsilon tubulin, putative	0.0301219	0.487242	0.458752
Trypanosoma cruzi	fructose-bisphosphate aldolase, glycosomal, putative	0.010081	0.122771	0.074029
Toxoplasma gondii	tubulin/FtsZ family, GTPase domain-containing protein	0.0130785	0.177286	0.176872
Echinococcus granulosus	tubulin alpha chain	0.0405648	0.677163	0.677163
Brugia malayi	Immunoglobulin I-set domain containing protein	0.012256	0.162327	0.161906
Echinococcus multilocularis	tubulin alpha 1C chain	0.0405648	0.677163	0.677163
Plasmodium falciparum	fructose-bisphosphate aldolase	0.010081	0.122771	0.12233
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0235215	0.367206	0.366888
Leishmania major	beta tubulin	0.0583164	1	1
Loa Loa (eye worm)	tubulin gamma chain	0.0301219	0.487242	0.487242
Trypanosoma brucei	beta tubulin	0.0583164	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.0130785	0.177286	0.176872
Leishmania major	alpha tubulin	0.0405648	0.677163	0.677001
Schistosoma mansoni	alpha tubulin	0.0405648	0.677163	0.677001
Loa Loa (eye worm)	tubulin beta chain	0.0583164	1	1
Giardia lamblia	Low molecular weight protein-tyrosine-phosphatase	0.0548778	0.937464	0.934025
Loa Loa (eye worm)	tubulin alpha-3 chain	0.0235215	0.367206	0.367206
Leishmania major	beta tubulin	0.0583164	1	1
Loa Loa (eye worm)	hypothetical protein	0.012256	0.162327	0.162327
Schistosoma mansoni	tubulin subunit beta	0.0583164	1	1
Plasmodium vivax	tubulin alpha chain, putative	0.0405648	0.677163	0.677001
Loa Loa (eye worm)	hypothetical protein	0.0235215	0.367206	0.367206
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.00335795	0.000502759	0.000502759
Schistosoma mansoni	ABC transporter	0.00530345	0.0358845	0.0353996
Echinococcus granulosus	tubulin alpha 1C chain	0.0405648	0.677163	0.677163
Echinococcus multilocularis	tubulin beta 1 chain	0.0583164	1	1
Leishmania major	ATP-binding cassette protein subfamily G, member 4, putative	0.00622469	0.0526385	0.052162
Leishmania major	fructose-1,6-bisphosphate aldolase	0.010081	0.122771	0.12233
Trichomonas vaginalis	tubulin, putative	0.0583164	1	1
Plasmodium vivax	ABC transporter G family member 2, putative	0.00622469	0.0526385	0.052162
Echinococcus granulosus	tubulin alpha 3 chain	0.0405648	0.677163	0.677163
Entamoeba histolytica	protein tyrosine phosphatase, putative	0.0548778	0.937464	0.937433
Trypanosoma cruzi	tubulin delta chain	0.0130785	0.177286	0.131573
Trichomonas vaginalis	conserved hypothetical protein	0.0130785	0.177286	0.176872
Leishmania major	alpha tubulin	0.0405648	0.677163	0.677001
Brugia malayi	fructose-bisphosphate aldolase 1	0.010081	0.122771	0.12233
Echinococcus multilocularis	beta tubulin	0.0583164	1	1
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0274863	0.439311	0.439029
Leishmania major	beta tubulin	0.0583164	1	1
Trypanosoma brucei	tubulin gamma chain	0.0301219	0.487242	0.458752
Echinococcus granulosus	TNFR CD27 30 40 95 cysteine rich region	0.0157594	0.226041	0.226041
Mycobacterium ulcerans	phosphotyrosine protein phosphatase PtpA	0.0548778	0.937464	1
Echinococcus multilocularis	Tubulin beta 2C chain	0.0583164	1	1
Schistosoma mansoni	tubulin subunit beta	0.0130785	0.177286	0.176872
Leishmania major	beta tubulin	0.0583164	1	1
Leishmania major	alpha tubulin	0.0405648	0.677163	0.677001
Plasmodium vivax	fructose 1,6-bisphosphate aldolase, putative	0.010081	0.122771	0.12233
Echinococcus granulosus	tubulin alpha chain	0.0405648	0.677163	0.677163
Brugia malayi	Tubulin beta-1 chain	0.0583164	1	1
Echinococcus multilocularis	hypothetical protein	0.0405648	0.677163	0.677163
Trypanosoma brucei	alpha tubulin	0.0405648	0.677163	0.659225
Schistosoma mansoni	hypothetical protein	0.012256	0.162327	0.161906
Trypanosoma cruzi	fructose-bisphosphate aldolase, glycosomal, putative	0.010081	0.122771	0.074029
Loa Loa (eye worm)	ABC transporter	0.00530345	0.0358845	0.0358845
Chlamydia trachomatis	ABC transporter ATP binding protein/permease	0.00335795	0.000502759	0.5
Leishmania major	delta tubulin, putative	0.0130785	0.177286	0.176872
Leishmania major	beta tubulin	0.0583164	1	1
Plasmodium falciparum	MO15-related protein kinase	0.0160042	0.230493	0.230106
Trypanosoma cruzi	epsilon tubulin, putative	0.0301219	0.487242	0.458752
Giardia lamblia	Beta tubulin	0.0583164	1	1
Mycobacterium tuberculosis	Probable conserved transmembrane ATP-binding protein ABC transporter	0.00527581	0.0353818	0.0372256
Echinococcus granulosus	tubulin delta chain	0.0130785	0.177286	0.177286
Brugia malayi	alpha-tubulin	0.0405648	0.677163	0.677001
Echinococcus granulosus	tubulin gamma 1 chain	0.0301219	0.487242	0.487242
Echinococcus multilocularis	tumor necrosis factor receptor superfamily	0.0157594	0.226041	0.226041
Echinococcus multilocularis	multidrug resistance protein 1	0.00335795	0.000502759	0.000502759
Brugia malayi	fructose-bisphosphate aldolase 2	0.010081	0.122771	0.12233
Trichomonas vaginalis	tubulin beta chain, putative	0.0405648	0.677163	0.677001
Echinococcus multilocularis	tubulin subunit beta	0.0583164	1	1
Leishmania major	zeta tubulin, putative	0.0130785	0.177286	0.176872
Leishmania major	alpha tubulin	0.0405648	0.677163	0.677001
Loa Loa (eye worm)	BEN-1 protein	0.0583164	1	1
Giardia lamblia	Alpha-tubulin	0.0405648	0.677163	0.659406
Leishmania major	beta tubulin	0.0583164	1	1
Plasmodium falciparum	alpha tubulin 1	0.0405648	0.677163	0.677001
Echinococcus multilocularis	TNFR CD27 30 40 95 cysteine rich region	0.0157594	0.226041	0.226041
Trypanosoma brucei	beta tubulin	0.0301219	0.487242	0.458752
Trichomonas vaginalis	tubulin gamma chain, putative	0.0583164	1	1
Plasmodium falciparum	ABC transporter G family member 2	0.00622469	0.0526385	0.052162
Echinococcus granulosus	tubulin subunit TubB	0.0405648	0.677163	0.677163
Trypanosoma cruzi	zeta tubulin, putative	0.0130785	0.177286	0.131573
Echinococcus granulosus	tubulin beta 4A class IVa	0.0583164	1	1
Echinococcus multilocularis	Tubulin beta 2C chain	0.0583164	1	1
Toxoplasma gondii	cell-cycle-associated protein kinase, putative	0.0148824	0.210092	0.209694
Schistosoma mansoni	fructose 16-bisphosphate aldolase	0.010081	0.122771	0.12233
Entamoeba histolytica	tubulin gamma chain	0.0301219	0.487242	0.486984
Echinococcus multilocularis	tubulin, beta 4A class IVa	0.0583164	1	1
Onchocerca volvulus		0.0170433	0.24939	0.265633
Loa Loa (eye worm)	tubulin alpha chain	0.0405648	0.677163	0.677163
Schistosoma mansoni	fructose 16-bisphosphate aldolase	0.010081	0.122771	0.12233
Plasmodium falciparum	tubulin beta chain	0.0583164	1	1
Leishmania major	beta tubulin	0.0583164	1	1
Echinococcus multilocularis	tubulin alpha	0.0301219	0.487242	0.487242
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	0.00335795	0.000502759	0.000502759
Plasmodium falciparum	tubulin delta chain, putative	0.0130785	0.177286	0.176872
Toxoplasma gondii	alpha-tubulin I, putative	0.0405648	0.677163	0.677001
Echinococcus granulosus	tubulin alpha	0.0301219	0.487242	0.487242
Plasmodium falciparum	tubulin epsilon chain, putative	0.0301219	0.487242	0.486984
Brugia malayi	Tubulin gamma chain	0.0301219	0.487242	0.486984
Echinococcus multilocularis	tubulin alpha chain	0.0405648	0.677163	0.677163
Brugia malayi	Tubulin alpha chain	0.0405648	0.677163	0.677001
Echinococcus multilocularis	tubulin alpha chain	0.0405648	0.677163	0.677163
Loa Loa (eye worm)	fructose-bisphosphate aldolase 2	0.010081	0.122771	0.122771
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.00335795	0.000502759	0.000502759
Mycobacterium ulcerans	flavin-containing monoamine oxidase AofH	0.0292179	0.470803	0.472596
Echinococcus granulosus	fructose 16 bisphosphate aldolase	0.010081	0.122771	0.122771
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0405648	0.677163	0.677001
Echinococcus granulosus	tubulin subunit beta	0.0583164	1	1
Trichomonas vaginalis	tubulin alpha chain, putative	0.0583164	1	1
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	0.00335795	0.000502759	0.000502759
Trypanosoma cruzi	tubulin delta chain	0.0130785	0.177286	0.131573
Echinococcus granulosus	Ankyrin	0.012256	0.162327	0.162327
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.00335795	0.000502759	0.000502759
Trypanosoma brucei	zeta tubulin, putative	0.0130785	0.177286	0.131573
Echinococcus granulosus	Tubulin alpha 1 chain	0.0405648	0.677163	0.677163
Echinococcus multilocularis	fructose 1,6 bisphosphate aldolase	0.010081	0.122771	0.122771
Trichomonas vaginalis	tubulin gamma chain, putative	0.0130785	0.177286	0.176872
Loa Loa (eye worm)	phosphotyrosine protein phosphatase	0.0548778	0.937464	0.937464
Brugia malayi	Tubulin alpha-2 chain	0.0405648	0.677163	0.677001
Leishmania major	alpha tubulin	0.0405648	0.677163	0.677001
Entamoeba histolytica	tubulin family protein	0.0583164	1	1
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.012256	0.162327	0.162327
Schistosoma mansoni	tubulin subunit alpha	0.0405648	0.677163	0.677001
Toxoplasma gondii	fructose-bisphosphate aldolase, putative	0.010081	0.122771	0.12233
Brugia malayi	ABC transporter family protein	0.00530345	0.0358845	0.0353996
Echinococcus granulosus	Tubulin alpha 1 chain	0.0405648	0.677163	0.677163
Onchocerca volvulus	Netrin receptor homolog	0.012256	0.162327	0.172712
Schistosoma mansoni	tubulin subunit beta	0.0583164	1	1
Leishmania major	beta tubulin	0.0583164	1	1
Trypanosoma brucei	epsilon tubulin	0.0301219	0.487242	0.458752
Trypanosoma cruzi	tubulin gamma chain	0.0301219	0.487242	0.458752
Trichomonas vaginalis	low molecular weight protein-tyrosine-phosphatase, putative	0.0548778	0.937464	0.937433
Brugia malayi	tubulin alpha-2 chain	0.0405648	0.677163	0.677001
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0405648	0.677163	0.677163
Echinococcus granulosus	ATP binding cassette sub family G	0.00622469	0.0526385	0.0526385
Toxoplasma gondii	ATP-binding cassette G family transporter ABCG84	0.00622469	0.0526385	0.052162
Schistosoma mansoni	tubulin subunit beta	0.0583164	1	1
Echinococcus multilocularis	tubulin alpha chain	0.0405648	0.677163	0.677163
Wolbachia endosymbiont of Brugia malayi	cell division protein FtsZ	0.0130785	0.177286	0.5
Entamoeba histolytica	ABC transporter, putative	0.00622469	0.0526385	0.052162
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0583164	1	1
Echinococcus granulosus	tubulin beta 1 chain	0.0583164	1	1
Schistosoma mansoni	tubulin subunit beta	0.0583164	1	1
Echinococcus multilocularis	Ankyrin	0.012256	0.162327	0.162327
Schistosoma mansoni	tubulin subunit alpha	0.0405648	0.677163	0.677001
Toxoplasma gondii	beta-1 tubulin, putative	0.0583164	1	1
Trichomonas vaginalis	tubulin alpha chain, putative	0.0301219	0.487242	0.486984
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0405648	0.677163	0.677001
Toxoplasma gondii	fructose-1,6-bisphosphate aldolase	0.010081	0.122771	0.12233
Loa Loa (eye worm)	tubulin beta-4 chain	0.0583164	1	1
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0405648	0.677163	0.677163
Echinococcus multilocularis	ATP binding cassette sub family G	0.00622469	0.0526385	0.0526385
Loa Loa (eye worm)	tubulin beta-1 chain	0.0583164	1	1
Trichomonas vaginalis	tubulin, putative	0.0170433	0.24939	0.249013
Loa Loa (eye worm)	tubulin alpha-2 chain	0.0405648	0.677163	0.677163
Echinococcus granulosus	tumor necrosis factor receptor superfamily	0.0157594	0.226041	0.226041
Brugia malayi	Death domain containing protein	0.012256	0.162327	0.161906
Leishmania major	alpha tubulin	0.0405648	0.677163	0.677001
Plasmodium vivax	tubulin gamma chain, putative	0.0301219	0.487242	0.486984
Giardia lamblia	Beta tubulin	0.0583164	1	1
Loa Loa (eye worm)	tubulin alpha 2	0.0274863	0.439311	0.439311
Brugia malayi	tubulin alpha chain - mouse	0.0405648	0.677163	0.677001
Toxoplasma gondii	alpha tubulin TUBA1	0.0405648	0.677163	0.677001
Trichomonas vaginalis	low molecular weight protein-tyrosine-phosphatase, putative	0.0548778	0.937464	0.937433
Loa Loa (eye worm)	hypothetical protein	0.00335795	0.000502759	0.000502759
Leishmania major	beta tubulin	0.0583164	1	1
Loa Loa (eye worm)	alpha-tubulin isotype 2	0.0274863	0.439311	0.439311
Loa Loa (eye worm)	tubulin beta-2A chain	0.0583164	1	1
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.0548778	0.937464	0.937433
Echinococcus multilocularis	ankyrin repeat and death domain containing protein	0.012256	0.162327	0.162327
Echinococcus granulosus	tubulin alpha chain	0.0405648	0.677163	0.677163
Echinococcus granulosus	Tubulin beta 2C chain	0.0583164	1	1
Plasmodium vivax	delta tubulin, putative	0.0130785	0.177286	0.176872
Toxoplasma gondii	beta-tubulin, putative	0.0583164	1	1
Echinococcus multilocularis	Tubulin beta 2C chain	0.0583164	1	1
Trichomonas vaginalis	tubulin beta chain, putative	0.0405648	0.677163	0.677001
Schistosoma mansoni	ATP-binding cassette sub-family g2 (white protein) (abcg2)	0.00622469	0.0526385	0.052162
Giardia lamblia	Beta tubulin	0.0583164	1	1
Loa Loa (eye worm)	ATP-binding cassette sub-family B member 2	0.00335795	0.000502759	0.000502759
Trypanosoma cruzi	fructose-bisphosphate aldolase, glycosomal, putative	0.010081	0.122771	0.074029
Trichomonas vaginalis	tubulin, putative	0.0130785	0.177286	0.176872
Leishmania major	alpha tubulin	0.0405648	0.677163	0.677001
Brugia malayi	Tubulin beta chain	0.0170433	0.24939	0.249013
Trypanosoma brucei	epsilon tubulin	0.0301219	0.487242	0.458752
Echinococcus granulosus	ATP binding cassette sub family G	0.00622469	0.0526385	0.0526385
Giardia lamblia	Alpha-tubulin	0.0405648	0.677163	0.659406
Leishmania major	beta tubulin	0.0583164	1	1
Echinococcus granulosus	multidrug resistance protein 1	0.00335795	0.000502759	0.000502759
Trichomonas vaginalis	tubulin beta chain, putative	0.0405648	0.677163	0.677001
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.0548778	0.937464	0.937433
Echinococcus multilocularis	tubulin alpha 3 chain	0.0405648	0.677163	0.677163
Schistosoma mansoni	tumor necrosis factor receptor related	0.0157594	0.226041	0.225652
Trypanosoma brucei	alpha tubulin	0.0405648	0.677163	0.659225
Schistosoma mansoni	alpha tubulin	0.0405648	0.677163	0.677001
Schistosoma mansoni	retinoblastoma-binding protein 4 (rbbp4)	0.012256	0.162327	0.161906
Echinococcus granulosus	ATP binding cassette sub family G	0.00622469	0.0526385	0.0526385
Trichomonas vaginalis	tubulin beta chain, putative	0.0405648	0.677163	0.677001
Plasmodium falciparum	alpha tubulin 2	0.0405648	0.677163	0.677001
Echinococcus granulosus	tubulin epsilon chain	0.0301219	0.487242	0.487242
Giardia lamblia	Epsilon tubulin	0.0130785	0.177286	0.132034
Schistosoma mansoni	tubulin subunit epsilon	0.0301219	0.487242	0.486984
Giardia lamblia	Gamma tubulin	0.0301219	0.487242	0.459039
Echinococcus multilocularis	tubulin epsilon chain	0.0301219	0.487242	0.487242
Brugia malayi	Tubulin beta chain	0.0130785	0.177286	0.176872
Brugia malayi	Cell division protein ftsZ	0.0130785	0.177286	0.176872
Loa Loa (eye worm)	fructose-bisphosphate aldolase 1	0.010081	0.122771	0.122771
Leishmania major	epsilon tubulin, putative	0.0301219	0.487242	0.486984
Mycobacterium tuberculosis	Cell division protein FtsZ	0.0130785	0.177286	0.188677
Plasmodium vivax	tubulin epsilon chain, putative	0.0301219	0.487242	0.486984
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0405648	0.677163	0.677001
Trypanosoma brucei	beta tubulin	0.0583164	1	1
Echinococcus granulosus	tubulin alpha 1C chain	0.0405648	0.677163	0.677163
Trypanosoma cruzi	fructose-bisphosphate aldolase, glycosomal, putative	0.010081	0.122771	0.074029
Echinococcus multilocularis	ATP binding cassette sub family G	0.00622469	0.0526385	0.0526385
Echinococcus granulosus	Tubulin beta 2C chain	0.0583164	1	1
Echinococcus multilocularis	tubulin alpha 3 chain	0.0405648	0.677163	0.677163
Brugia malayi	Tubulin alpha chain	0.0130785	0.177286	0.176872
Echinococcus multilocularis	fructose 1,6 bisphosphate aldolase	0.010081	0.122771	0.122771
Echinococcus granulosus	fructose bisphosphate aldolase class I	0.010081	0.122771	0.122771
Leishmania major	beta tubulin	0.0583164	1	1
Schistosoma mansoni	ankyrin 23/unc44	0.012256	0.162327	0.161906
Echinococcus multilocularis	netrin receptor unc 5	0.012256	0.162327	0.162327
Plasmodium falciparum	tubulin gamma chain	0.0301219	0.487242	0.486984
Trichomonas vaginalis	tubulin beta chain, putative	0.0583164	1	1
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	0.00335795	0.000502759	0.000502759
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.00335795	0.000502759	0.000502759
Brugia malayi	Tubulin alpha-2 chain	0.0405648	0.677163	0.677001
Schistosoma mansoni	hypothetical protein	0.00527581	0.0353818	0.0348965
Loa Loa (eye worm)	multidrug resistance protein 3	0.00335795	0.000502759	0.000502759
Echinococcus multilocularis	tubulin alpha chain	0.0405648	0.677163	0.677163
Echinococcus multilocularis	ATP binding cassette sub family G	0.00622469	0.0526385	0.0526385
Toxoplasma gondii	tubulin/FtsZ family, GTPase domain-containing protein	0.0130785	0.177286	0.176872
Echinococcus granulosus	Tubulin beta 2C chain	0.0583164	1	1

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)		Antiparasitic activity against Trypanosoma brucei rhodesiense STIB900	ChEMBL.	19010569
IC50 (functional)	= 0.634 ug ml-1	Antiparasitic activity against Plasmodium falciparum K1	ChEMBL.	19010569
Inhibition (functional)	<= 50 %	Antiparasitic activity against Leishmania donovani MHOM-ET/67/L82 at 0.81 ug/ml	ChEMBL.	19010569
Inhibition (functional)	<= 50 %	Antiparasitic activity against Trypanosoma cruzi Tulahuen C4 containing lacz gene at 0.81 ug/ml	ChEMBL.	19010569
Inhibition (functional)	<= 70 %	Antiparasitic activity against Leishmania donovani MHOM-ET/67/L82 at 4.85 ug/ml	ChEMBL.	19010569
Inhibition (functional)	<= 70 %	Antiparasitic activity against Trypanosoma cruzi Tulahuen C4 containing lacz gene at 4.85 ug/ml	ChEMBL.	19010569
MIC (functional)	= 50 ug ml-1	Antifungal activity against Candida albicans ATCC 10231 by macro-broth dilution method	ChEMBL.	19010569

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum		19010569

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL488780

Bibliographic References

No literature references available for this target.

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Detailed information for compound 993234