Detailed information for compound 998115

Basic information

Technical information
  • TDR Targets ID: 998115
  • Name: 1'-[6-(trifluoromethyl)-1H-benzimidazol-2-yl] spiro[2-benzofuran-3,4'-piperidine]-1-one
  • MW: 387.355 | Formula: C20H16F3N3O2
  • H donors: 1 H acceptors: 2 LogP: 4.29 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1OC2(c3c1cccc3)CCN(CC2)c1nc2c([nH]1)ccc(c2)C(F)(F)F
  • InChi: 1S/C20H16F3N3O2/c21-20(22,23)12-5-6-15-16(11-12)25-18(24-15)26-9-7-19(8-10-26)14-4-2-1-3-13(14)17(27)28-19/h1-6,11H,7-10H2,(H,24,25)
  • InChiKey: GOSQWFMKXKORBV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1'-[6-(trifluoromethyl)-1H-benzimidazol-2-yl]spiro[isobenzofuran-3,4'-piperidine]-1-one
  • 1'-[6-(trifluoromethyl)-1H-benzimidazol-2-yl]-1-spiro[isobenzofuran-3,4'-piperidine]one

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens neuropeptide Y receptor Y5 Starlite/ChEMBL References
Homo sapiens neuropeptide Y receptor Y1 Starlite/ChEMBL References
Homo sapiens neuropeptide Y receptor type 4-like Starlite/ChEMBL References
Homo sapiens neuropeptide Y receptor Y2 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis neuropeptide receptor Get druggable targets OG5_127863 All targets in OG5_127863
Echinococcus granulosus neuropeptide receptor Get druggable targets OG5_127863 All targets in OG5_127863
Schistosoma japonicum ko:K04209 neuropeptide Y receptor, invertebrate, putative Get druggable targets OG5_127863 All targets in OG5_127863
Echinococcus multilocularis G protein coupled receptor 139 Get druggable targets OG5_127863 All targets in OG5_127863
Schistosoma mansoni neuropeptide receptor Get druggable targets OG5_127863 All targets in OG5_127863
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi follicle stimulating hormone receptor neuropeptide Y receptor type 4-like 375 aa 346 aa 23.1 %
Echinococcus granulosus pyroglutamylated rfamide peptide receptor neuropeptide Y receptor Y2 381 aa 388 aa 20.4 %
Brugia malayi follicle stimulating hormone receptor neuropeptide Y receptor Y1 384 aa 345 aa 22.0 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0784 0.1002
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0172 0.5846 0.5044
Loa Loa (eye worm) BEN-1 protein 0.0227 0.7823 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0204 0.0237
Echinococcus granulosus tubulin alpha chain 0.0172 0.5846 0.7473
Leishmania major beta tubulin 0.0227 0.7823 1
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.007 0.2197 0.069
Trichomonas vaginalis tubulin alpha chain, putative 0.007 0.2197 0.069
Echinococcus multilocularis orexin receptor type 2 0.0014 0.0204 0.026
Schistosoma mansoni neuropeptide f receptor 76f 0.0014 0.0204 0.026
Loa Loa (eye worm) hypothetical protein 0.0014 0.0204 0.0237
Echinococcus granulosus biogenic amine 5HT receptor 0.0014 0.0204 0.026
Schistosoma mansoni tubulin subunit beta 0.0227 0.7823 1
Plasmodium vivax tubulin alpha chain, putative 0.0172 0.5846 0.7288
Loa Loa (eye worm) TYRA-2 protein 0.0014 0.0204 0.0237
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0784 0.1002
Brugia malayi hypothetical protein 0.0014 0.0204 0.0188
Echinococcus multilocularis Tubulin beta 2C chain 0.0227 0.7823 1
Echinococcus granulosus tubulin alpha 3 chain 0.0172 0.5846 0.7473
Echinococcus multilocularis tubulin alpha chain 0.0172 0.5846 0.7473
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0014 0.0204 0.026
Echinococcus granulosus hypothetical protein 0.0014 0.0204 0.026
Schistosoma mansoni opsin-like receptor 0.0014 0.0204 0.026
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0014 0.0204 0.026
Entamoeba histolytica hypothetical protein 0.0036 0.0978 0.0469
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0288 1 1
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0014 0.0204 0.026
Loa Loa (eye worm) hypothetical protein 0.0014 0.0204 0.0237
Entamoeba histolytica tubulin family protein 0.0227 0.7823 0.77
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0014 0.0204 0.026
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0014 0.0204 0.026
Loa Loa (eye worm) hypothetical protein 0.0014 0.0204 0.0237
Schistosoma mansoni amine GPCR 0.0014 0.0204 0.026
Schistosoma mansoni tubulin subunit alpha 0.0053 0.1619 0.2069
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0014 0.0204 0.026
Trypanosoma cruzi alpha tubulin, putative 0.0172 0.5846 0.7426
Echinococcus granulosus g-protein coupled receptor 0.0014 0.0204 0.026
Echinococcus multilocularis hypothetical protein 0.0172 0.5846 0.7473
Onchocerca volvulus Huntingtin homolog 0.0121 0.4026 0.4855
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0014 0.0204 0.026
Loa Loa (eye worm) hypothetical protein 0.0014 0.0204 0.0237
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0023 0.0533 0.5
Echinococcus multilocularis g protein coupled receptor 0.0014 0.0204 0.026
Entamoeba histolytica tubulin gamma chain 0.0123 0.4105 0.3773
Echinococcus granulosus tachykinin peptides receptor 99D 0.0014 0.0204 0.026
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0784 0.0344
Trichomonas vaginalis tubulin gamma chain, putative 0.0123 0.4105 0.2967
Brugia malayi Cytochrome P450 family protein 0.0012 0.0143 0.011
Plasmodium falciparum tubulin gamma chain 0.0123 0.4105 0.49
Echinococcus multilocularis allatostatin A receptor 0.0014 0.0204 0.026
Echinococcus multilocularis jun protein 0.0083 0.2669 0.3411
Echinococcus granulosus beta tubulin 0.0227 0.7823 1
Leishmania major beta tubulin 0.0227 0.7823 1
Mycobacterium tuberculosis Cell division protein FtsZ 0.0053 0.1619 0.2582
Plasmodium falciparum tubulin delta chain, putative 0.0053 0.1619 0.1489
Loa Loa (eye worm) hypothetical protein 0.0014 0.0204 0.0237
Echinococcus multilocularis rhodopsin orphan GPCR 0.0014 0.0204 0.026
Echinococcus granulosus tubulin beta 4A class IVa 0.0227 0.7823 1
Schistosoma mansoni amine GPCR 0.0014 0.0204 0.026
Echinococcus multilocularis neuropeptides capa receptor 0.0014 0.0204 0.026
Trichomonas vaginalis tubulin alpha chain, putative 0.007 0.2197 0.069
Plasmodium vivax tubulin gamma chain, putative 0.0123 0.4105 0.49
Onchocerca volvulus 0.003 0.0784 0.0737
Loa Loa (eye worm) transcription factor SMAD2 0.0118 0.3913 0.4991
Schistosoma mansoni alpha tubulin 0.0172 0.5846 0.7473
Giardia lamblia Alpha-tubulin 0.0172 0.5846 0.5044
Echinococcus multilocularis G-protein coupled receptor, putative 0.0014 0.0204 0.026
Schistosoma mansoni hypothetical protein 0.0014 0.0204 0.026
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0978 0.125
Loa Loa (eye worm) hypothetical protein 0.0014 0.0204 0.0237
Leishmania major alpha tubulin 0.0172 0.5846 0.7426
Echinococcus multilocularis rhodopsin orphan GPCR 0.0014 0.0204 0.026
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0784 0.1002
Echinococcus granulosus tubulin alpha chain 0.0172 0.5846 0.7473
Plasmodium vivax tubulin alpha chain, putative 0.0172 0.5846 0.7288
Brugia malayi bZIP transcription factor family protein 0.0083 0.2669 0.3362
Plasmodium falciparum alpha tubulin 2 0.0172 0.5846 0.7288
Brugia malayi hypothetical protein 0.0014 0.0204 0.0188
Brugia malayi neuropeptide F receptor 0.0014 0.0204 0.0188
Trypanosoma brucei epsilon tubulin 0.0123 0.4105 0.5159
Leishmania major alpha tubulin 0.0172 0.5846 0.7426
Echinococcus granulosus tubulin alpha chain 0.0172 0.5846 0.7473
Loa Loa (eye worm) hypothetical protein 0.0014 0.0204 0.0237
Loa Loa (eye worm) hypothetical protein 0.0081 0.2587 0.3292
Echinococcus granulosus tubulin epsilon chain 0.0123 0.4105 0.5248
Trypanosoma brucei tubulin gamma chain 0.0123 0.4105 0.5159
Leishmania major beta tubulin 0.0227 0.7823 1
Leishmania major beta tubulin 0.0227 0.7823 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0014 0.0204 0.026
Trypanosoma brucei tubulin delta chain 0.0053 0.1619 0.1921
Echinococcus granulosus tubulin subunit TubB 0.0172 0.5846 0.7473
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0014 0.0204 0.026
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0014 0.0204 0.026
Brugia malayi hypothetical protein 0.0036 0.0978 0.1185
Echinococcus granulosus L aminoadipate semialdehyde 0.0082 0.2637 0.3371
Loa Loa (eye worm) hypothetical protein 0.0014 0.0204 0.0237
Leishmania major beta tubulin 0.0227 0.7823 1
Brugia malayi hypothetical protein 0.0121 0.4026 0.5111
Leishmania major delta tubulin, putative 0.0053 0.1619 0.1921
Trichomonas vaginalis tubulin gamma chain, putative 0.0227 0.7823 0.7402
Leishmania major beta tubulin 0.0227 0.7823 1
Trypanosoma cruzi tubulin delta chain 0.0053 0.1619 0.1921
Echinococcus granulosus somatostatin receptor 0.0014 0.0204 0.026
Leishmania major beta tubulin 0.0227 0.7823 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0014 0.0204 0.026
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0014 0.0204 0.026
Echinococcus multilocularis rhodopsin orphan GPCR 0.0014 0.0204 0.026
Loa Loa (eye worm) hypothetical protein 0.0014 0.0204 0.0237
Schistosoma mansoni biogenic amine (5HT) receptor 0.0014 0.0204 0.026
Echinococcus multilocularis tubulin alpha 1C chain 0.0172 0.5846 0.7473
Loa Loa (eye worm) tubulin alpha chain 0.0172 0.5846 0.7467
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.1893 0.242
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0784 0.1002
Loa Loa (eye worm) hypothetical protein 0.0014 0.0204 0.0237
Schistosoma mansoni tubulin subunit epsilon 0.0123 0.4105 0.5248
Loa Loa (eye worm) histone methyltransferase 0.001 0.0062 0.0055
Brugia malayi Cytochrome P450 family protein 0.0012 0.0143 0.011
Plasmodium falciparum tubulin beta chain 0.0227 0.7823 1
Loa Loa (eye worm) tubulin beta-4 chain 0.0227 0.7823 1
Leishmania major beta tubulin 0.0227 0.7823 1
Trypanosoma brucei epsilon tubulin 0.0123 0.4105 0.5159
Schistosoma mansoni histamine h1 receptor 0.0014 0.0204 0.026
Echinococcus multilocularis neuropeptide s receptor 0.0014 0.0204 0.026
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0014 0.0204 0.026
Echinococcus granulosus tubulin beta 1 chain 0.0227 0.7823 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0288 1 1
Treponema pallidum fructose-bisphosphate aldolase 0.0288 1 1
Brugia malayi Tubulin gamma chain 0.0123 0.4105 0.5213
Echinococcus multilocularis Tubulin beta 2C chain 0.0227 0.7823 1
Echinococcus granulosus neuropeptide receptor 0.0199 0.6815 0.8712
Echinococcus multilocularis Tubulin beta 2C chain 0.0227 0.7823 1
Echinococcus multilocularis tubulin alpha 3 chain 0.0172 0.5846 0.7473
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0014 0.0204 0.026
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0014 0.0204 0.026
Brugia malayi Dopamine receptor protein 2 0.0014 0.0204 0.0188
Loa Loa (eye worm) tubulin alpha 2 0.0118 0.3938 0.5022
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0014 0.0204 0.026
Echinococcus granulosus 7TM GPCR rhodopsin 0.0014 0.0204 0.026
Echinococcus granulosus rhodopsin orphan GPCR 0.0014 0.0204 0.026
Trypanosoma cruzi epsilon tubulin, putative 0.0123 0.4105 0.5159
Brugia malayi Dopamine receptor 0.0014 0.0204 0.0188
Onchocerca volvulus 0.0028 0.0721 0.0657
Schistosoma mansoni tubulin subunit beta 0.0227 0.7823 1
Echinococcus granulosus Tubulin alpha 1 chain 0.0172 0.5846 0.7473
Loa Loa (eye worm) hypothetical protein 0.003 0.0784 0.0981
Loa Loa (eye worm) hypothetical protein 0.0014 0.0204 0.0237
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0014 0.0204 0.0237
Loa Loa (eye worm) hypothetical protein 0.0014 0.0204 0.0237
Loa Loa (eye worm) hypothetical protein 0.0014 0.0204 0.0237
Echinococcus granulosus beta tubulin 0.0227 0.7823 1
Leishmania major beta tubulin 0.0227 0.7823 1
Schistosoma mansoni hypothetical protein 0.0167 0.568 0.726
Echinococcus multilocularis neuropeptide Y receptor 0.0014 0.0204 0.026
Echinococcus granulosus g protein coupled receptor 0.0014 0.0204 0.026
Loa Loa (eye worm) beta-tubulin 0.0227 0.7823 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0014 0.0204 0.026
Trypanosoma brucei alpha tubulin 0.0172 0.5846 0.7426
Echinococcus multilocularis tubulin gamma 1 chain 0.0123 0.4105 0.5248
Brugia malayi Serotonin receptor 0.0014 0.0204 0.0188
Schistosoma mansoni tubulin subunit alpha 0.0172 0.5846 0.7473
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0062 0.0079
Onchocerca volvulus 0.0234 0.8077 1
Echinococcus multilocularis g protein coupled receptor 0.0014 0.0204 0.026
Loa Loa (eye worm) BEN-1 protein 0.0227 0.7823 1
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0014 0.0204 0.0237
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0014 0.0204 0.0188
Echinococcus granulosus g protein coupled receptor 0.0014 0.0204 0.026
Echinococcus granulosus neuropeptide Y receptor 0.0014 0.0204 0.026
Brugia malayi Tubulin beta chain 0.0053 0.1619 0.201
Schistosoma mansoni neuropeptide F-like receptor 0.0014 0.0204 0.026
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0288 1 1
Echinococcus multilocularis tubulin alpha 3 chain 0.0172 0.5846 0.7473
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0082 0.2637 0.3322
Echinococcus granulosus Tubulin alpha 1 chain 0.0172 0.5846 0.7473
Schistosoma mansoni tubulin subunit beta 0.0053 0.1619 0.2069
Echinococcus multilocularis tubulin alpha chain 0.0172 0.5846 0.7473
Schistosoma mansoni tubulin subunit beta 0.0227 0.7823 1
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0014 0.0204 0.026
Leishmania major alpha tubulin 0.0172 0.5846 0.7426
Brugia malayi Pre-SET motif family protein 0.0206 0.7064 0.9023
Echinococcus multilocularis neuropeptide FF receptor 2 0.0014 0.0204 0.026
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0014 0.0204 0.0188
Echinococcus multilocularis L aminoadipate semialdehyde 0.0082 0.2637 0.3371
Schistosoma mansoni alpha tubulin 0.0172 0.5846 0.7473
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0141 0.4737 1
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0141 0.4737 1
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0123 0.4105 0.49
Trichomonas vaginalis tubulin, putative 0.007 0.2197 0.069
Loa Loa (eye worm) hypothetical protein 0.0014 0.0204 0.0237
Echinococcus multilocularis rhodopsin orphan GPCR 0.0014 0.0204 0.026
Brugia malayi sulfakinin receptor protein 0.0014 0.0204 0.0188
Entamoeba histolytica hypothetical protein 0.0036 0.0978 0.0469
Brugia malayi hypothetical protein 0.0014 0.0204 0.0188
Brugia malayi Cell division protein ftsZ 0.0053 0.1619 0.201
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0014 0.0204 0.0237
Brugia malayi hypothetical protein 0.0014 0.0204 0.0188
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0082 0.2637 0.3371
Trichomonas vaginalis tubulin epsilon chain, putative 0.0172 0.5846 0.5044
Echinococcus granulosus Tubulin beta 2C chain 0.0227 0.7823 1
Giardia lamblia Gamma tubulin 0.0123 0.4105 0.2967
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0014 0.0204 0.0237
Schistosoma mansoni adenoreceptor 0.0014 0.0204 0.026
Loa Loa (eye worm) hypothetical protein 0.0014 0.0204 0.0237
Loa Loa (eye worm) hypothetical protein 0.0014 0.0204 0.0237
Loa Loa (eye worm) neuropeptide F receptor 0.0014 0.0204 0.0237
Trypanosoma cruzi epsilon tubulin, putative 0.0123 0.4105 0.5159
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0014 0.0204 0.0188
Leishmania major alpha tubulin 0.0172 0.5846 0.7426
Brugia malayi Tubulin alpha chain 0.0053 0.1619 0.201
Brugia malayi RE15519p 0.0014 0.0204 0.0188
Echinococcus multilocularis rhodopsin orphan GPCR 0.0014 0.0204 0.026
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0083 0.2669 0.3411
Loa Loa (eye worm) hypothetical protein 0.0118 0.3938 0.5022
Trypanosoma brucei epsilon tubulin 0.0123 0.4105 0.5159
Echinococcus granulosus tubulin delta chain 0.0053 0.1619 0.2069
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0014 0.0204 0.026
Echinococcus multilocularis beta tubulin 0.0227 0.7823 1
Treponema pallidum cell division protein FtsZ 0.0053 0.1619 0.1146
Wolbachia endosymbiont of Brugia malayi cell division protein FtsZ 0.0053 0.1619 1
Echinococcus multilocularis tubulin subunit TubB 0.0172 0.5846 0.7473
Echinococcus granulosus Tubulin beta 2C chain 0.0227 0.7823 1
Brugia malayi hypothetical protein 0.0014 0.0204 0.0188
Echinococcus granulosus Tubulin alpha 1 chain 0.0172 0.5846 0.7473
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0978 0.125
Loa Loa (eye worm) hypothetical protein 0.0014 0.0204 0.0237
Plasmodium vivax SET domain protein, putative 0.003 0.0784 0.0344
Echinococcus granulosus tubulin alpha chain 0.0172 0.5846 0.7473
Brugia malayi G-protein coupled receptor 0.0014 0.0204 0.0188
Schistosoma mansoni growth hormone secretagogue receptor 0.0014 0.0204 0.026
Plasmodium vivax tubulin beta chain, putative 0.0227 0.7823 1
Echinococcus multilocularis fmrfamide receptor 0.0014 0.0204 0.026
Trypanosoma cruzi zeta tubulin, putative 0.0053 0.1619 0.1921
Plasmodium vivax delta tubulin, putative 0.0053 0.1619 0.1489
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0014 0.0204 0.026
Onchocerca volvulus 0.0065 0.2033 0.2324
Schistosoma mansoni cpg binding protein 0.003 0.0779 0.0996
Echinococcus multilocularis tubulin beta 1 chain 0.0227 0.7823 1
Schistosoma mansoni hypothetical protein 0.0014 0.0204 0.026
Loa Loa (eye worm) cytochrome P450 family protein 0.0012 0.0143 0.016
Echinococcus multilocularis tubulin subunit beta 0.0227 0.7823 1
Schistosoma mansoni hypothetical protein 0.0036 0.0978 0.125
Brugia malayi follicle stimulating hormone receptor 0.0014 0.0204 0.0188
Echinococcus granulosus cpg binding protein 0.003 0.0779 0.0996
Leishmania major beta tubulin 0.0227 0.7823 1
Mycobacterium leprae cell division protein FtsZ 0.0053 0.1619 0.2582
Echinococcus multilocularis rhodopsin orphan GPCR 0.0014 0.0204 0.026
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0288 1 1
Brugia malayi hypothetical protein 0.0014 0.0204 0.0188
Echinococcus granulosus neuropeptides capa receptor 0.0014 0.0204 0.026
Trichomonas vaginalis tubulin beta chain, putative 0.0172 0.5846 0.5044
Loa Loa (eye worm) alpha-tubulin isotype 2 0.0118 0.3938 0.5022
Echinococcus multilocularis tubulin, beta 4A class IVa 0.0227 0.7823 1
Echinococcus multilocularis tubulin delta chain 0.0053 0.1619 0.2069
Trypanosoma brucei alpha tubulin, putative 0.007 0.2197 0.2674
Loa Loa (eye worm) tubulin beta chain 0.0227 0.7823 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0014 0.0204 0.026
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0014 0.0204 0.026
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0014 0.0204 0.026
Entamoeba histolytica tubulin family protein 0.0227 0.7823 0.77
Echinococcus multilocularis g protein coupled receptor 0.0014 0.0204 0.026
Brugia malayi Pre-SET motif family protein 0.003 0.0784 0.0935
Trypanosoma brucei alpha tubulin 0.0172 0.5846 0.7426
Trypanosoma brucei beta tubulin 0.0227 0.7823 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0204 0.0237
Brugia malayi hypothetical protein 0.0065 0.2033 0.2544
Brugia malayi CXXC zinc finger family protein 0.0028 0.0721 0.0855
Trichomonas vaginalis tubulin epsilon chain, putative 0.0172 0.5846 0.5044
Loa Loa (eye worm) hypothetical protein 0.0102 0.3359 0.428
Echinococcus multilocularis rhodopsin orphan GPCR 0.0014 0.0204 0.026
Loa Loa (eye worm) hypothetical protein 0.0014 0.0204 0.0237
Giardia lamblia Beta tubulin 0.0227 0.7823 0.7402
Echinococcus granulosus tubulin alpha 1C chain 0.0172 0.5846 0.7473
Loa Loa (eye worm) hypothetical protein 0.0014 0.0204 0.0237
Leishmania major zeta tubulin, putative 0.0053 0.1619 0.1921
Schistosoma mansoni hypothetical protein 0.0014 0.0204 0.026
Giardia lamblia Beta tubulin 0.0227 0.7823 0.7402
Loa Loa (eye worm) hypothetical protein 0.0082 0.2637 0.3355
Loa Loa (eye worm) hypothetical protein 0.0014 0.0204 0.0237
Echinococcus granulosus alpha tubulin 0.0172 0.5846 0.7473
Trypanosoma cruzi tubulin delta chain 0.0053 0.1619 0.1921
Trypanosoma cruzi tubulin gamma chain 0.0123 0.4105 0.5159
Plasmodium vivax tubulin epsilon chain, putative 0.0123 0.4105 0.49
Trypanosoma brucei zeta tubulin, putative 0.0053 0.1619 0.1921
Echinococcus multilocularis Tubulin alpha 1 chain 0.0172 0.5846 0.7473
Echinococcus multilocularis cpg binding protein 0.003 0.0779 0.0996
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0206 0.7064 0.9028
Plasmodium falciparum tubulin epsilon chain, putative 0.0123 0.4105 0.49
Loa Loa (eye worm) tubulin beta-2A chain 0.0227 0.7823 1
Schistosoma mansoni alpha-1 adrenergic receptor 0.0014 0.0204 0.026
Loa Loa (eye worm) neuropeptide F receptor 0.0014 0.0204 0.0237
Echinococcus multilocularis tubulin alpha chain 0.0172 0.5846 0.7473
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0723 0.0924
Leishmania major beta tubulin 0.0227 0.7823 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0014 0.0204 0.026
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0014 0.0204 0.026
Loa Loa (eye worm) hypothetical protein 0.0014 0.0204 0.0237
Brugia malayi hypothetical protein 0.0014 0.0204 0.0188
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0014 0.0204 0.0237
Schistosoma mansoni neuropeptide receptor 0.0014 0.0204 0.026
Loa Loa (eye worm) hypothetical protein 0.0121 0.4026 0.5135
Echinococcus multilocularis g-protein coupled receptor 0.0014 0.0204 0.026
Trypanosoma brucei alpha tubulin 0.0172 0.5846 0.7426
Echinococcus granulosus 7tm_1 domain containing protein 0.0014 0.0204 0.026
Brugia malayi beta-tubulin, identical 0.0227 0.7823 1
Giardia lamblia Beta tubulin 0.0227 0.7823 0.7402
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0141 0.4737 1
Brugia malayi Melatonin receptor type 1A 0.0014 0.0204 0.0188
Echinococcus granulosus tm gpcr rhodopsin 0.0014 0.0204 0.026
Leishmania major gamma-tubulin 0.0123 0.4105 0.5159
Schistosoma mansoni tubulin subunit gamma 0.0123 0.4105 0.5248
Trypanosoma brucei alpha tubulin 0.0172 0.5846 0.7426
Leishmania major alpha tubulin 0.0172 0.5846 0.7426
Loa Loa (eye worm) G-protein coupled receptor 0.0014 0.0204 0.0237
Loa Loa (eye worm) hypothetical protein 0.0014 0.0204 0.0237
Brugia malayi MH2 domain containing protein 0.0118 0.3913 0.4965
Echinococcus granulosus fmrfamide receptor 0.0014 0.0204 0.026
Loa Loa (eye worm) tubulin beta chain 0.0053 0.1619 0.205
Loa Loa (eye worm) hypothetical protein 0.0014 0.0204 0.0237
Loa Loa (eye worm) melatonin receptor type 1A 0.0014 0.0204 0.0237
Toxoplasma gondii beta-1 tubulin, putative 0.0227 0.7823 1
Loa Loa (eye worm) G-protein coupled receptor 0.0014 0.0204 0.0237
Trichomonas vaginalis tubulin, putative 0.007 0.2197 0.069
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0014 0.0204 0.0188
Loa Loa (eye worm) hypothetical protein 0.0014 0.0204 0.0237
Schistosoma mansoni jun-related protein 0.0067 0.2114 0.2703
Toxoplasma gondii histone lysine methyltransferase SET1 0.0055 0.1664 0.1552
Schistosoma mansoni biogenic amine receptor 0.0014 0.0204 0.026
Echinococcus granulosus G protein coupled receptor 139 0.0014 0.0204 0.026
Echinococcus granulosus tubulin subunit beta 0.0227 0.7823 1
Trichomonas vaginalis tubulin gamma chain, putative 0.0123 0.4105 0.2967
Echinococcus multilocularis tubulin alpha 1C chain 0.0172 0.5846 0.7473
Echinococcus granulosus geminin 0.0167 0.568 0.726
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0014 0.0204 0.026
Schistosoma mansoni neuropeptide receptor 0.0014 0.0204 0.026
Schistosoma mansoni opsin-like receptor 0.0014 0.0204 0.026
Echinococcus multilocularis tubulin alpha 0.0123 0.4105 0.5248
Leishmania major alpha tubulin 0.0172 0.5846 0.7426
Echinococcus granulosus neuropeptide receptor A26 0.0014 0.0204 0.026
Trypanosoma cruzi beta tubulin, putative 0.0227 0.7823 1
Onchocerca volvulus Huntingtin homolog 0.0121 0.4026 0.4855
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0014 0.0204 0.026
Loa Loa (eye worm) hypothetical protein 0.0014 0.0204 0.0237
Loa Loa (eye worm) hypothetical protein 0.0014 0.0204 0.0237
Echinococcus multilocularis Tubulin alpha 1 chain 0.0172 0.5846 0.7473
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0014 0.0204 0.026
Leishmania major beta tubulin 0.0227 0.7823 1
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0014 0.0204 0.026
Brugia malayi hypothetical protein 0.0014 0.0204 0.0188
Onchocerca volvulus 0.007 0.2197 0.2532
Toxoplasma gondii beta tubulin 0.0227 0.7823 1
Echinococcus granulosus tm gpcr rhodopsin 0.0014 0.0204 0.026
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0784 0.1002
Echinococcus multilocularis Tubulin beta 2C chain 0.0227 0.7823 1
Trypanosoma brucei zeta tubulin 0.0053 0.1619 0.1921
Echinococcus multilocularis peroxisome assembly protein 26 0.0172 0.5846 0.7473
Echinococcus granulosus rhodopsin orphan GPCR 0.0014 0.0204 0.026
Leishmania major beta tubulin 0.0227 0.7823 1
Loa Loa (eye worm) tubulin beta-1 chain 0.0227 0.7823 1
Schistosoma mansoni cpg binding protein 0.0028 0.0721 0.0922
Loa Loa (eye worm) hypothetical protein 0.0014 0.0204 0.0237
Entamoeba histolytica tubulin alpha-1 chain 0.0172 0.5846 0.5612
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0014 0.0204 0.0188
Loa Loa (eye worm) hypothetical protein 0.0014 0.0204 0.0237
Schistosoma mansoni amine GPCR 0.0014 0.0204 0.026
Brugia malayi Tubulin beta-1 chain 0.0227 0.7823 1
Trichomonas vaginalis tubulin beta chain, putative 0.0227 0.7823 0.7402
Loa Loa (eye worm) CYP4Cod1 0.0012 0.0143 0.016
Brugia malayi ORL1-like opioid receptor 0.0014 0.0204 0.0188
Echinococcus granulosus tubulin alpha 0.0123 0.4105 0.5248
Mycobacterium ulcerans cell division protein FtsZ 0.0053 0.1619 0.3212
Echinococcus granulosus tubulin alpha chain 0.0172 0.5846 0.7473
Schistosoma mansoni tubulin subunit beta 0.0227 0.7823 1
Echinococcus granulosus serotonin receptor 0.0014 0.0204 0.026
Schistosoma mansoni neuropeptide F-like receptor 0.0014 0.0204 0.026
Loa Loa (eye worm) tubulin alpha 2 0.0118 0.3938 0.5022
Echinococcus granulosus rhodopsin orphan GPCR 0.0014 0.0204 0.026
Loa Loa (eye worm) hypothetical protein 0.0014 0.0204 0.0237
Echinococcus multilocularis neuropeptide receptor 0.0014 0.0204 0.026
Echinococcus granulosus dro:myosuppressin receptor 0.0014 0.0204 0.026
Brugia malayi Tachykinin-like peptides receptor 99D 0.0014 0.0204 0.0188
Schistosoma mansoni tubulin subunit delta 0.0053 0.1619 0.2069
Trichomonas vaginalis tubulin epsilon chain, putative 0.0227 0.7823 0.7402
Brugia malayi G protein-coupled receptor F59B2.13 0.0014 0.0204 0.0188
Echinococcus multilocularis serotonin receptor 0.0014 0.0204 0.026
Schistosoma mansoni amine GPCR 0.0014 0.0204 0.026
Echinococcus multilocularis neuropeptide Y receptor 0.0014 0.0204 0.026
Brugia malayi Serotonin receptor 0.0014 0.0204 0.0188
Schistosoma mansoni opsin-like receptor 0.0014 0.0204 0.026
Schistosoma mansoni biogenic amine (5HT) receptor 0.0014 0.0204 0.026
Schistosoma mansoni neuropeptide receptor 0.0014 0.0204 0.026
Leishmania major alpha tubulin 0.0172 0.5846 0.7426
Echinococcus multilocularis Tubulin alpha 1 chain 0.0172 0.5846 0.7473
Leishmania major beta tubulin 0.0227 0.7823 1
Echinococcus granulosus alpha 1A adrenergic receptor 0.0014 0.0204 0.026
Schistosoma mansoni hypothetical protein 0.0014 0.0204 0.026
Trypanosoma brucei beta tubulin 0.0227 0.7823 1
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0102 0.3359 0.2077
Trypanosoma brucei beta tubulin 0.0227 0.7823 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0014 0.0204 0.026
Loa Loa (eye worm) hypothetical protein 0.0014 0.0204 0.0237
Loa Loa (eye worm) tubulin alpha-3 chain 0.0102 0.3359 0.428
Echinococcus multilocularis tubulin alpha chain 0.0172 0.5846 0.7473
Echinococcus granulosus sex peptide receptor 0.0014 0.0204 0.026
Echinococcus granulosus neuropeptide receptor 0.0014 0.0204 0.026
Echinococcus granulosus g protein coupled receptor 0.0014 0.0204 0.026
Brugia malayi putative neuropeptide receptor 0.0014 0.0204 0.0188
Trypanosoma brucei beta tubulin 0.0123 0.4105 0.5159
Trichomonas vaginalis tubulin beta chain, putative 0.007 0.2197 0.069
Schistosoma mansoni biogenic amine receptor 0.0014 0.0204 0.026
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0014 0.0204 0.026
Echinococcus multilocularis serotonin receptor 0.0014 0.0204 0.026
Schistosoma mansoni tubulin subunit beta 0.0227 0.7823 1
Brugia malayi hypothetical protein 0.0014 0.0204 0.0188
Echinococcus granulosus peptide allatostatin:somatostatin 0.0014 0.0204 0.026
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0014 0.0204 0.026
Loa Loa (eye worm) hypothetical protein 0.0014 0.0204 0.0237
Brugia malayi tubulin alpha chain - mouse 0.0172 0.5846 0.7454
Loa Loa (eye worm) hypothetical protein 0.0014 0.0204 0.0237
Toxoplasma gondii alpha tubulin TUBA1 0.0172 0.5846 0.7288
Schistosoma mansoni hypothetical protein 0.0067 0.2114 0.2703
Schistosoma mansoni hypothetical protein 0.0051 0.1532 0.1959
Echinococcus granulosus tubulin alpha 3 chain 0.0172 0.5846 0.7473
Leishmania major beta tubulin 0.0227 0.7823 1
Leishmania major alpha tubulin 0.0172 0.5846 0.7426
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0784 0.1002
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0118 0.3938 0.2767
Echinococcus multilocularis neuropeptides capa receptor 0.0014 0.0204 0.026
Echinococcus granulosus tm gpcr rhodopsin 0.0014 0.0204 0.026
Schistosoma mansoni cpg binding protein 0.003 0.0779 0.0996
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0288 1 1
Echinococcus multilocularis tubulin epsilon chain 0.0123 0.4105 0.5248
Loa Loa (eye worm) tubulin alpha chain 0.0172 0.5846 0.7467
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0062 0.0079
Leishmania major phosphopantetheinyl transferase-like protein 0.0023 0.0533 0.0508
Trichomonas vaginalis tubulin beta chain, putative 0.0172 0.5846 0.5044
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0014 0.0204 0.026
Echinococcus multilocularis beta tubulin 0.0227 0.7823 1
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0023 0.0533 0.0849
Loa Loa (eye worm) tubulin alpha-2 chain 0.0172 0.5846 0.7467
Schistosoma mansoni tubulin subunit beta 0.0227 0.7823 1
Echinococcus granulosus orexin receptor type 2 0.0014 0.0204 0.026
Trichomonas vaginalis tubulin, putative 0.0227 0.7823 0.7402
Loa Loa (eye worm) alpha-tubulin 0.0172 0.5846 0.7467
Echinococcus multilocularis Tubulin beta 2C chain 0.0227 0.7823 1
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0083 0.2669 0.3411
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0014 0.0204 0.026
Entamoeba histolytica hypothetical protein 0.0036 0.0978 0.0469
Leishmania major epsilon tubulin, putative 0.0123 0.4105 0.5159
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0288 1 1
Brugia malayi Tubulin alpha-2 chain 0.0172 0.5846 0.7454
Echinococcus multilocularis dro:myosuppressin receptor 0.0014 0.0204 0.026
Schistosoma mansoni tubulin subunit alpha 0.0172 0.5846 0.7473
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0014 0.0204 0.026
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0014 0.0204 0.026
Echinococcus multilocularis sex peptide receptor 0.0014 0.0204 0.026
Leishmania major beta tubulin 0.0227 0.7823 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0288 1 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0014 0.0204 0.026
Echinococcus multilocularis G protein coupled receptor 139 0.0199 0.6815 0.8712
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0288 1 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0288 1 1
Brugia malayi Tubulin alpha chain 0.0172 0.5846 0.7454
Leishmania major alpha tubulin 0.0172 0.5846 0.7426
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0014 0.0204 0.026
Echinococcus granulosus tubulin gamma 1 chain 0.0123 0.4105 0.5248
Brugia malayi larval opioid receptor 0.0014 0.0204 0.0188
Loa Loa (eye worm) hypothetical protein 0.0014 0.0204 0.0237
Echinococcus granulosus Tubulin beta 2C chain 0.0227 0.7823 1
Loa Loa (eye worm) tubulin alpha 2 0.0049 0.1451 0.1835
Brugia malayi putative neuropeptide receptor NPR1 0.0014 0.0204 0.0188
Echinococcus granulosus neuropeptide s receptor 0.0014 0.0204 0.026
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0014 0.0204 0.026
Brugia malayi tubulin alpha-2 chain 0.0172 0.5846 0.7454
Echinococcus granulosus tubulin alpha 1C chain 0.0172 0.5846 0.7473
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0053 0.1619 0.1489
Leishmania major alpha tubulin 0.0172 0.5846 0.7426
Echinococcus granulosus peroxisome assembly protein 26 0.0172 0.5846 0.7473
Echinococcus granulosus Tubulin beta 2C chain 0.0227 0.7823 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0118 0.3913 0.4991
Brugia malayi hypothetical protein 0.0014 0.0204 0.0188
Echinococcus granulosus Tubulin beta 2C chain 0.0227 0.7823 1
Trichomonas vaginalis tubulin beta chain, putative 0.0172 0.5846 0.5044
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0014 0.0204 0.026
Giardia lamblia Alpha-tubulin 0.0172 0.5846 0.5044
Echinococcus multilocularis tubulin alpha chain 0.0172 0.5846 0.7473
Plasmodium falciparum alpha tubulin 1 0.0172 0.5846 0.7288
Trichomonas vaginalis tubulin alpha chain, putative 0.0123 0.4105 0.2967
Loa Loa (eye worm) tubulin gamma chain 0.0123 0.4105 0.5237
Echinococcus granulosus neuropeptide FF receptor 2 0.0014 0.0204 0.026
Toxoplasma gondii alpha-tubulin I, putative 0.0172 0.5846 0.7288
Echinococcus granulosus neuropeptides capa receptor 0.0014 0.0204 0.026
Brugia malayi Dopamine receptor protein 1 0.0014 0.0204 0.0188
Schistosoma mansoni myosin xvIII 0.0014 0.0204 0.026
Echinococcus multilocularis geminin 0.0167 0.568 0.726
Leishmania major beta tubulin 0.0227 0.7823 1
Brugia malayi G protein-coupled receptor 0.0014 0.0204 0.0188
Leishmania major beta tubulin 0.0227 0.7823 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0784 0.1002
Trichomonas vaginalis tubulin beta chain, putative 0.0172 0.5846 0.5044
Brugia malayi Tubulin alpha-2 chain 0.0172 0.5846 0.7454
Loa Loa (eye worm) hypothetical protein 0.0014 0.0204 0.0237
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0014 0.0204 0.026
Leishmania major alpha tubulin 0.0172 0.5846 0.7426
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0023 0.0533 0.0849
Toxoplasma gondii beta-tubulin, putative 0.0227 0.7823 1
Echinococcus multilocularis somatostatin receptor 0.0014 0.0204 0.026
Schistosoma mansoni tubulin subunit alpha 0.0172 0.5846 0.7473
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0014 0.0204 0.026
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0978 0.125
Echinococcus granulosus allatostatin A receptor 0.0014 0.0204 0.026
Trypanosoma cruzi zeta tubulin, putative 0.0053 0.1619 0.1921
Brugia malayi GnHR receptor homolog 0.0014 0.0204 0.0188
Brugia malayi Tubulin beta chain 0.007 0.2197 0.2755
Brugia malayi AKH receptor 0.0014 0.0204 0.0188
Schistosoma mansoni biogenic amine receptor 0.0014 0.0204 0.026
Loa Loa (eye worm) alpha-tubulin 0.0172 0.5846 0.7467
Brugia malayi G-protein coupled receptor 0.0014 0.0204 0.0188
Entamoeba histolytica hypothetical protein 0.0036 0.0978 0.0469
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0014 0.0204 0.026
Trichomonas vaginalis tubulin beta chain, putative 0.0172 0.5846 0.5044
Trypanosoma brucei hypothetical protein, conserved 0.0023 0.0533 0.0508
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0053 0.1619 0.1489
Brugia malayi neuropeptide F receptor 0.0014 0.0204 0.0188
Loa Loa (eye worm) hypothetical protein 0.0121 0.4026 0.5135
Schistosoma mansoni neuropeptide receptor 0.0199 0.6815 0.8712
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0721 0.09
Trichomonas vaginalis tubulin beta chain, putative 0.0172 0.5846 0.5044
Schistosoma mansoni alpha tubulin 0.0172 0.5846 0.7473
Echinococcus granulosus neuropeptide Y receptor 0.0014 0.0204 0.026
Schistosoma mansoni amine GPCR 0.0014 0.0204 0.026
Loa Loa (eye worm) hypothetical protein 0.0014 0.0204 0.0237
Echinococcus granulosus biogenic amine 5HT receptor 0.0014 0.0204 0.026
Onchocerca volvulus 0.0082 0.2637 0.3091
Echinococcus granulosus jun protein 0.0083 0.2669 0.3411
Schistosoma mansoni hypothetical protein 0.0167 0.568 0.726
Trypanosoma brucei beta tubulin 0.0227 0.7823 1
Giardia lamblia Fructose-bisphosphate aldolase 0.0288 1 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0204 0.0237
Echinococcus multilocularis fmrfamide receptor 0.0014 0.0204 0.026
Loa Loa (eye worm) hypothetical protein 0.0014 0.0204 0.0237
Loa Loa (eye worm) hypothetical protein 0.0172 0.5846 0.7467
Trichomonas vaginalis set domain proteins, putative 0.0234 0.8077 0.7706
Echinococcus multilocularis neuropeptide receptor 0.0199 0.6815 0.8712
Trichomonas vaginalis tubulin epsilon chain, putative 0.0227 0.7823 0.7402
Loa Loa (eye worm) hypothetical protein 0.0014 0.0204 0.0237
Loa Loa (eye worm) hypothetical protein 0.0014 0.0204 0.0237
Loa Loa (eye worm) cytochrome P450 family protein 0.0012 0.0143 0.016
Trichomonas vaginalis tubulin alpha chain, putative 0.007 0.2197 0.069
Loa Loa (eye worm) hypothetical protein 0.0014 0.0204 0.0237
Echinococcus granulosus rhodopsin orphan GPCR 0.0014 0.0204 0.026
Brugia malayi alpha-tubulin 0.0172 0.5846 0.7454
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0014 0.0204 0.026
Echinococcus multilocularis neuropeptide receptor A26 0.0014 0.0204 0.026
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0014 0.0204 0.026
Entamoeba histolytica tubulin alpha chain, putative 0.0172 0.5846 0.5612
Loa Loa (eye worm) hypothetical protein 0.0014 0.0204 0.0237
Loa Loa (eye worm) hypothetical protein 0.0014 0.0204 0.0237
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0014 0.0204 0.026
Leishmania major alpha tubulin 0.0172 0.5846 0.7426
Loa Loa (eye worm) hypothetical protein 0.0014 0.0204 0.0237
Trichomonas vaginalis tubulin alpha chain, putative 0.0227 0.7823 0.7402

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 3.5 nM Binding affinity to human NPY Y5 receptor transfected in mouse LMtk cells ChEMBL. 18723347
IC50 (binding) > 10000 nM Binding affinity to NPY Y1 receptor ChEMBL. 18723347
IC50 (binding) > 10000 nM Binding affinity to NPY Y2 receptor ChEMBL. 18723347
IC50 (binding) > 10000 nM Binding affinity to NPY Y4 receptor ChEMBL. 18723347
IC50 (functional) = 6.4 uM Antagonist activity at human NPY Y5 receptor transfected in mouse LMtk cells assessed as inhibition of neuropeptide Y-induced increase in intercellular Ca2+ level ChEMBL. 18723347

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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