Detailed information for compound 1007692

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 420.257 | Formula: C18H18BrN3O4
  • H donors: 0 H acceptors: 2 LogP: 3.59 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(cc(c1OC)OC)n1nncc1c1ccc(c(c1)Br)OC
  • InChi: 1S/C18H18BrN3O4/c1-23-15-6-5-11(7-13(15)19)14-10-20-21-22(14)12-8-16(24-2)18(26-4)17(9-12)25-3/h5-10H,1-4H3
  • InChiKey: FGUKVEHZMNJKPK-UHFFFAOYSA-N  


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Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium falciparum histone acetyltransferase GCN5 0.0043 0.0212 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0047 0.0237 0.1307
Trypanosoma brucei unspecified product 0.0015 0.0038 0.013
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0027 0.0111 0.0194
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0012 0.0015 0.0071
Echinococcus multilocularis dnaJ subfamily B 0.0453 0.2783 0.2781
Echinococcus granulosus cpg binding protein 0.0034 0.0152 0.0149
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0067 0.0359 0.0356
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0067 0.0363 0.036
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0067 0.0364 0.035
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0043 0.021 0.1091
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0012 0.0015 0.0081
Trypanosoma brucei kinesin, putative 0.0019 0.0059 0.0249
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0021 0.0037
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0038 0.013
Brugia malayi follicle stimulating hormone receptor 0.0274 0.1661 0.9204
Brugia malayi Cytochrome P450 family protein 0.0021 0.0076 0.0419
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0022 0.0082 0.0079
Schistosoma mansoni hypothetical protein 0.0056 0.0292 0.0278
Schistosoma mansoni inositol monophosphatase 0.0043 0.021 0.0196
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.0404 0.2176
Schistosoma mansoni Mername-AA248 (C02 family) 0.0019 0.0059 0.0045
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0043 0.021 0.4935
Mycobacterium ulcerans TetR family transcriptional regulator 0.0807 0.5 1
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0013 0.0021 0.0037
Echinococcus multilocularis lamin 0.0083 0.046 0.0458
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0082 0.0373
Brugia malayi nuclear hormone receptor 0.0012 0.0015 0.0081
Trichomonas vaginalis bromodomain-containing protein, putative 0.0047 0.0237 0.5631
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0067 0.0359 0.0691
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0013 0.0021 0.0118
Echinococcus multilocularis dna polymerase kappa 0.0022 0.0082 0.0079
Trypanosoma cruzi kinesin, putative 0.0019 0.0059 0.0249
Echinococcus granulosus beta LACTamase domain containing family member 0.0074 0.0404 0.0402
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0047 0.0237 0.0235
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0074 0.0404 0.2241
Leishmania major phosphopantetheinyl transferase-like protein 0.0027 0.0111 0.054
Echinococcus multilocularis survival motor neuron protein 1 0.0275 0.1664 0.1662
Echinococcus granulosus calpain A 0.0019 0.0059 0.0057
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0082 0.0373
Loa Loa (eye worm) hypothetical protein 0.0063 0.0339 0.1869
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0063 0.0339 0.0325
Schistosoma mansoni aldehyde dehydrogenase 0.0067 0.0363 0.0349
Loa Loa (eye worm) thioredoxin reductase 0.0037 0.0173 0.095
Echinococcus multilocularis calpain 7 (C02 family) 0.0019 0.0059 0.0057
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0021 0.0037
Mycobacterium tuberculosis Conserved hypothetical protein 0.0022 0.0082 0.0135
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0027 0.0111 0.248
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0019 0.0059 0.0249
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0019 0.0059 0.0249
Brugia malayi calpain family protein 1 0.0063 0.0339 0.1877
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0013 0.0021 0.0037
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0019 0.0059 0.0249
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0404 1
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0097 0.0547 0.303
Loa Loa (eye worm) hypothetical protein 0.0102 0.0582 0.3216
Toxoplasma gondii aldehyde dehydrogenase 0.0067 0.0363 0.8932
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0021 0.0037
Brugia malayi glutathione reductase 0.0037 0.0173 0.0959
Plasmodium vivax thioredoxin reductase, putative 0.0037 0.0173 0.3961
Echinococcus granulosus ubiquitin specific protease 41 0.0043 0.021 0.0208
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0083 0.046 0.2544
Echinococcus granulosus histone acetyltransferase KAT2B 0.0156 0.092 0.0917
Onchocerca volvulus 0.0083 0.046 0.8375
Brugia malayi photoreceptor-specific nuclear receptor 0.0012 0.0015 0.0081
Trypanosoma cruzi DNA polymerase eta, putative 0.0037 0.017 0.0868
Trypanosoma brucei calpain-like protein, putative 0.0019 0.0059 0.0249
Trypanosoma brucei hypothetical protein, conserved 0.0027 0.0111 0.054
Leishmania major calpain, putative,cysteine peptidase, Clan CA, family C2, putative 0.0019 0.0059 0.0249
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0082 0.0373
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0047 0.0237 0.0235
Mycobacterium tuberculosis Conserved protein 0.0074 0.0404 0.0787
Loa Loa (eye worm) MH2 domain-containing protein 0.0117 0.0677 0.3747
Plasmodium falciparum glutathione reductase 0.0037 0.0173 0.7944
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0043 0.021 0.4927
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0027 0.0111 0.0195
Mycobacterium tuberculosis Probable esterase LipL 0.0074 0.0404 0.0787
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0012 0.0015 0.0012
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0013 0.0021 0.0037
Schistosoma mansoni cellular tumor antigen P53 0.0057 0.0301 0.0287
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0067 0.0363 0.1943
Echinococcus granulosus intermediate filament protein 0.0083 0.046 0.0458
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0043 0.021 0.1093
Schistosoma mansoni transcription factor LCR-F1 0.0042 0.0203 0.0189
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0019 0.0059 0.0249
Echinococcus multilocularis beta LACTamase domain containing family member 0.0074 0.0404 0.0402
Echinococcus multilocularis neuropeptide s receptor 0.046 0.2826 0.2824
Echinococcus granulosus geminin 0.0197 0.1176 0.1174
Brugia malayi MH2 domain containing protein 0.0117 0.0677 0.3753
Mycobacterium ulcerans DNA polymerase IV 0.0022 0.0082 0.0134
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0015 0.0081
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0042 0.0203 0.0201
Schistosoma mansoni lamin 0.0083 0.046 0.0446
Brugia malayi Intermediate filament tail domain containing protein 0.0083 0.046 0.2551
Schistosoma mansoni calpain-7 (C02 family) 0.0022 0.0081 0.0067
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0043 0.021 0.9871
Trypanosoma brucei hypothetical protein, conserved 0.0074 0.0404 0.2176
Plasmodium falciparum thioredoxin reductase 0.0037 0.0173 0.7944
Loa Loa (eye worm) hypothetical protein 0.0083 0.046 0.2544
Loa Loa (eye worm) hypothetical protein 0.0074 0.0404 0.2233
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0161 0.0948 0.0946
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0297 0.1806 1
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.0404 0.2176
Schistosoma mansoni intermediate filament proteins 0.0083 0.046 0.0446
Brugia malayi calpain 5 0.0019 0.0059 0.0328
Schistosoma mansoni cpg binding protein 0.0032 0.014 0.0126
Mycobacterium ulcerans esterase/lipase LipP 0.0074 0.0404 0.0782
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0027 0.0111 1
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0043 0.021 0.0392
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0074 0.0404 0.039
Echinococcus multilocularis calpain 5 0.0019 0.0059 0.0057
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0015 0.0081
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0013 0.0021 0.0037
Loa Loa (eye worm) calpain family protein 1 0.0063 0.0339 0.1869
Brugia malayi intermediate filament protein 0.0083 0.046 0.2551
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0021 0.0037
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0043 0.021 0.4927
Trypanosoma brucei DNA polymerase IV, putative 0.0022 0.0082 0.0373
Echinococcus granulosus cytochrome P450 2K1 0.0012 0.0015 0.0012
Toxoplasma gondii hypothetical protein 0.0048 0.0242 0.5825
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0021 0.0037
Entamoeba histolytica hypothetical protein 0.0027 0.0111 0.3399
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.0067 0.0359 0.0357
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0043 0.021 0.1091
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0043 0.021 0.9896
Schistosoma mansoni hypothetical protein 0.0047 0.0237 0.0223
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0404 1
Leishmania major DNA polymerase eta, putative 0.0052 0.0267 0.141
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0037 0.0173 0.032
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0067 0.0359 0.0356
Brugia malayi steroid hormone receptor 0.0012 0.0015 0.0081
Echinococcus multilocularis dna polymerase eta 0.0052 0.0267 0.0265
Toxoplasma gondii thioredoxin reductase 0.0037 0.0173 0.4065
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0043 0.021 0.1093
Loa Loa (eye worm) cytochrome P450 family protein 0.0021 0.0076 0.0409
Echinococcus granulosus inositol monophosphatase 1 0.0043 0.021 0.0208
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0038 0.0182 0.0337
Loa Loa (eye worm) hypothetical protein 0.0038 0.0182 0.1
Echinococcus granulosus protein tyrosine kinase 0.0294 0.1783 0.1781
Echinococcus granulosus survival motor neuron protein 1 0.0275 0.1664 0.1662
Loa Loa (eye worm) hypothetical protein 0.0043 0.021 0.1157
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0203 0.1052
Mycobacterium tuberculosis Probable reductase 0.0084 0.0471 0.092
Trypanosoma cruzi kinesin, putative 0.0019 0.0059 0.0249
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0012 0.0015 0.0012
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0013 0.0021 0.0019
Echinococcus granulosus calpain A 0.0067 0.0359 0.0357
Mycobacterium ulcerans aldehyde dehydrogenase 0.0067 0.0363 0.0698
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0094 0.053 0.1039
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0013 0.0021 0.0013
Echinococcus multilocularis musashi 0.0083 0.046 0.0458
Loa Loa (eye worm) hypothetical protein 0.0012 0.0015 0.0071
Echinococcus multilocularis tumor protein p63 0.0393 0.2404 0.2402
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0067 0.0359 0.0345
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0043 0.021 1
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0047 0.0237 0.5631
Loa Loa (eye worm) hypothetical protein 0.0012 0.0015 0.0071
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0067 0.0359 0.0691
Giardia lamblia Histone acetyltransferase GCN5 0.0043 0.0212 1
Brugia malayi cytoplasmic intermediate filament protein 0.0044 0.0219 0.1214
Brugia malayi hypothetical protein 0.0042 0.0203 0.1125
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0082 0.0373
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0022 0.0082 0.0079
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0084 0.0471 0.0915
Loa Loa (eye worm) hypothetical protein 0.0012 0.0015 0.0071
Schistosoma mansoni hypothetical protein 0.0047 0.0237 0.0223
Loa Loa (eye worm) hypothetical protein 0.0045 0.022 0.1212
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0021 0.0037
Schistosoma mansoni aldehyde dehydrogenase 0.0067 0.0363 0.0349
Brugia malayi Cytochrome P450 family protein 0.0021 0.0076 0.0419
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0222 0.0219
Echinococcus multilocularis lamin dm0 0.0083 0.046 0.0458
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0012 0.0015 0.0012
Trypanosoma brucei calpain-like protein, putative 0.0019 0.0059 0.0249
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0067 0.0359 0.1922
Schistosoma mansoni hypothetical protein 0.0102 0.0582 0.0568
Trypanosoma cruzi cytochrome P450, putative 0.0021 0.0076 0.034
Loa Loa (eye worm) transcription factor SMAD2 0.0117 0.0677 0.3747
Mycobacterium ulcerans aldehyde dehydrogenase 0.0067 0.0363 0.0698
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0042 0.0203 0.1052
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0067 0.0359 0.0695
Brugia malayi hypothetical protein 0.0275 0.1664 0.9222
Onchocerca volvulus 0.0032 0.014 0.2365
Brugia malayi Calcitonin receptor-like protein seb-1 0.0149 0.0878 0.4865
Echinococcus granulosus FTZ F1 alpha 0.0012 0.0015 0.0012
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0043 0.021 0.1093
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0013 0.0021 0.0172
Brugia malayi nuclear receptor NHR-88 0.0012 0.0015 0.0081
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0019 0.0059 0.0249
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0012 0.0015 0.0071
Loa Loa (eye worm) calpain 0.0019 0.0059 0.0319
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0012 0.0015 0.0081
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0013 0.0021 0.0037
Schistosoma mansoni hypothetical protein 0.0197 0.1176 0.1163
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0013 0.0021 0.0019
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0067 0.0359 0.0345
Entamoeba histolytica hypothetical protein 0.0042 0.0203 0.9394
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0082 0.0373
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0082 0.0373
Mycobacterium tuberculosis Conserved protein 0.0074 0.0404 0.0787
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0012 0.0015 0.0012
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0097 0.0547 0.0533
Mycobacterium tuberculosis Probable lipase LipE 0.0074 0.0404 0.0787
Brugia malayi ImpB/MucB/SamB family protein 0.0022 0.0082 0.0452
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0082 0.0373
Echinococcus granulosus neuropeptide receptor A26 0.046 0.2826 0.2824
Onchocerca volvulus 0.0074 0.0404 0.7325
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0013 0.0021 0.0037
Brugia malayi calpain 7 0.0019 0.0059 0.0328
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0015 0.0081
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0013 0.0021 0.0037
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0013 0.0021 0.0037
Brugia malayi F/Y-rich N-terminus family protein 0.001 0.0002 0.001
Mycobacterium ulcerans transcriptional regulator 0.0807 0.5 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0222 0.0219
Mycobacterium ulcerans AcrR family transcriptional regulator 0.0807 0.5 1
Trypanosoma brucei cytochrome P450, putative 0.0021 0.0076 0.034
Brugia malayi Thioredoxin reductase 0.0037 0.0173 0.0959
Schistosoma mansoni terminal deoxycytidyl transferase 0.0022 0.0082 0.0067
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0044 0.0219 0.1206
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0019 0.0059 0.0249
Brugia malayi CXXC zinc finger family protein 0.0032 0.014 0.0778
Trypanosoma brucei unspecified product 0.0022 0.0082 0.0373
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0022 0.0082 0.0373
Loa Loa (eye worm) inositol-1 0.0043 0.021 0.1155
Schistosoma mansoni calpain-7 (C02 family) 0.0022 0.0081 0.0067
Echinococcus granulosus dna polymerase eta 0.0052 0.0267 0.0265
Mycobacterium ulcerans aldehyde dehydrogenase 0.0067 0.0363 0.0698
Echinococcus multilocularis cpg binding protein 0.0034 0.0152 0.0149
Loa Loa (eye worm) cytochrome P450 family protein 0.0033 0.0147 0.0807
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0013 0.0021 0.0013
Trypanosoma brucei DNA polymerase IV, putative 0.0022 0.0082 0.0373
Loa Loa (eye worm) acetyltransferase 0.0161 0.0948 0.5248
Leishmania major DNA polymerase eta, putative 0.0037 0.017 0.0868
Trichomonas vaginalis penicillin-binding protein, putative 0.0074 0.0404 1
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0297 0.1806 1
Brugia malayi Steroid receptor seven-up type 2 0.0012 0.0015 0.0081
Echinococcus granulosus dna polymerase kappa 0.0022 0.0082 0.0079
Echinococcus multilocularis L aminoadipate semialdehyde 0.0097 0.0547 0.0544
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0019 0.0059 0.0249
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0043 0.021 0.1091
Echinococcus multilocularis protein tyrosine kinase 0.0294 0.1783 0.1781
Loa Loa (eye worm) hypothetical protein 0.0057 0.0301 0.1662
Echinococcus multilocularis calpain A 0.0067 0.0359 0.0357
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0047 0.0237 0.5706
Echinococcus multilocularis FTZ F1 alpha 0.0012 0.0015 0.0012
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0047 0.0237 0.1316
Leishmania major mitochondrial DNA polymerase beta 0.0297 0.1806 1
Brugia malayi beta-lactamase family protein 0.0074 0.0404 0.2241
Brugia malayi beta-lactamase 0.0074 0.0404 0.2241
Echinococcus multilocularis thioredoxin glutathione reductase 0.0038 0.0176 0.0174
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0084 0.0471 0.092
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0013 0.0021 0.0007
Echinococcus granulosus cytoplasmic intermediate filament protein 0.004 0.0192 0.0189
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0019 0.0059 0.0249
Schistosoma mansoni hypothetical protein 0.0197 0.1176 0.1163
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0141 0.0824 0.4516
Schistosoma mansoni hypothetical protein 0.0042 0.0203 0.0189
Schistosoma mansoni cpg binding protein 0.0034 0.0152 0.0137
Echinococcus multilocularis calpain 0.0019 0.0059 0.0057
Brugia malayi Inositol-1 0.0043 0.021 0.1164
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0047 0.0237 0.0235
Mycobacterium leprae Probable transcriptional regulatory repressor protein (TetR-family) EthR 0.0807 0.5 1
Leishmania major DNA polymerase kappa, putative 0.0022 0.0082 0.0373
Echinococcus multilocularis geminin 0.0197 0.1176 0.1174
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0082 0.0373
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0042 0.0203 0.1052
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0019 0.0059 0.0249
Loa Loa (eye worm) hypothetical protein 0.0097 0.0547 0.3023
Entamoeba histolytica hypothetical protein 0.0042 0.0203 0.9394
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.004 0.0192 0.0189
Toxoplasma gondii NADPH-glutathione reductase 0.0013 0.0021 0.0172
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0404 1
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0012 0.0015 0.0081
Loa Loa (eye worm) cytochrome P450 0.0012 0.0015 0.0071
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0012 0.0015 0.0012
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0027 0.0111 0.2348
Brugia malayi Latrophilin receptor protein 2 0.0047 0.0237 0.1316
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0222 0.122
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0022 0.0082 0.0067
Loa Loa (eye worm) hypothetical protein 0.0081 0.0451 0.2491
Loa Loa (eye worm) hypothetical protein 0.0038 0.0182 0.1
Echinococcus multilocularis calpain family protein 1, d 0.0045 0.022 0.0218
Loa Loa (eye worm) calpain 5 0.0019 0.0059 0.0319
Leishmania major kinesin, putative 0.0019 0.0059 0.0249
Trypanosoma brucei calpain-like protein, putative 0.0019 0.0059 0.0249
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0015 0.0012
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0021 0.0076 0.0122
Mycobacterium leprae Probable lipase LipE 0.0074 0.0404 0.0782
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0047 0.0237 0.5706
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0012 0.0015 0.0012
Plasmodium vivax calpain, putative 0.0019 0.0059 0.099
Echinococcus granulosus ecdysone induced protein 78C 0.0012 0.0015 0.0012
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0019 0.0059 0.0249
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0082 0.0373
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0094 0.053 0.1039
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0015 0.0012
Onchocerca volvulus 0.0074 0.0404 0.7325
Loa Loa (eye worm) hypothetical protein 0.0074 0.0404 0.2233
Echinococcus granulosus lamin 0.0083 0.046 0.0458
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0012 0.0015 0.0012
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0067 0.0359 0.0345
Mycobacterium tuberculosis Conserved protein 0.0074 0.0404 0.0787
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0015 0.0081
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0015 0.0081
Mycobacterium tuberculosis Probable oxidoreductase 0.0094 0.053 0.1039
Brugia malayi cytochrome P450 0.0012 0.0015 0.0081
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0222 0.0219
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0082 0.0373
Loa Loa (eye worm) hypothetical protein 0.0149 0.0878 0.486
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0013 0.0021 0.0013
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0027 0.0111 0.4767
Echinococcus multilocularis neuropeptide receptor A26 0.046 0.2826 0.2824
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0038 0.013
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0274 0.1661 0.9203
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0027 0.0111 0.0194
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0082 0.0373
Mycobacterium tuberculosis Transcriptional regulatory repressor protein (TetR-family) EthR 0.0802 0.497 1
Echinococcus granulosus calpain 5 0.0019 0.0059 0.0057
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0074 0.0404 0.2233
Schistosoma mansoni inositol monophosphatase 0.0043 0.021 0.0196
Trypanosoma brucei antigen, putative 0.0019 0.0059 0.0249
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0037 0.017 0.3991
Trypanosoma brucei unspecified product 0.0015 0.0038 0.013
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0043 0.021 0.985
Schistosoma mansoni hypothetical protein 0.0453 0.2783 0.2773
Giardia lamblia DINP protein human, muc B family 0.0022 0.0082 0.315
Schistosoma mansoni DNA polymerase eta 0.0052 0.0267 0.0253
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0222 0.0207
Echinococcus granulosus thioredoxin glutathione reductase 0.0038 0.0176 0.0174
Onchocerca volvulus 0.0057 0.0301 0.5388
Trypanosoma brucei trypanothione reductase 0.0037 0.0173 0.0885
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0043 0.021 0.5014
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0012 0.0015 0.0071
Entamoeba histolytica hypothetical protein 0.0042 0.0203 0.9394
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0084 0.0471 0.092
Echinococcus granulosus GPCR family 2 0.0047 0.0237 0.0235
Loa Loa (eye worm) hypothetical protein 0.0012 0.0015 0.0071
Schistosoma mansoni hypothetical protein 0.0047 0.0237 0.0223
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0038 0.013
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0084 0.0471 0.092
Schistosoma mansoni microtubule-associated protein tau 0.1604 1 1
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0141 0.0824 0.4516
Trypanosoma brucei DNA polymerase IV, putative 0.0022 0.0082 0.0373
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0074 0.0404 0.039
Onchocerca volvulus 0.0074 0.0404 0.7325
Plasmodium vivax hypothetical protein, conserved 0.0074 0.0404 1
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0013 0.0021 0.0037
Onchocerca volvulus 0.0097 0.0547 1
Trypanosoma cruzi trypanothione reductase, putative 0.0037 0.0173 0.0885
Toxoplasma gondii histone lysine methyltransferase SET1 0.0064 0.0344 0.844
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0027 0.0111 1
Entamoeba histolytica deoxycytidyl transferase, putative 0.0022 0.0082 0.1455
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0015 0.0012
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0082 0.0373
Brugia malayi Protein kinase domain containing protein 0.0297 0.1805 1
Trichomonas vaginalis esterase, putative 0.0074 0.0404 1
Mycobacterium ulcerans hypothetical protein 0.0074 0.0404 0.0782
Brugia malayi latrophilin 2 splice variant baaae 0.0102 0.0582 0.3222
Brugia malayi ecdysteroid receptor 0.0012 0.0015 0.0081
Echinococcus granulosus L aminoadipate semialdehyde 0.0097 0.0547 0.0544
Echinococcus granulosus histone acetyltransferase KAT2B 0.0047 0.0237 0.0234
Loa Loa (eye worm) CYP4Cod1 0.0021 0.0076 0.0409
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0043 0.021 0.0208
Leishmania major hypothetical protein, conserved 0.0074 0.0404 0.2176
Brugia malayi Cytochrome P450 family protein 0.0033 0.0147 0.0816
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0012 0.0015 0.0012
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0012 0.0015 0.0071
Echinococcus granulosus dnaJ subfamily B 0.0453 0.2783 0.2781
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0149 0.0878 0.486
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0043 0.021 0.4935
Toxoplasma gondii ABC1 family protein 0.0074 0.0404 1
Mycobacterium tuberculosis Probable dehydrogenase 0.0084 0.0471 0.092
Entamoeba histolytica acetyltransferase, GNAT family 0.0043 0.0212 1
Mycobacterium ulcerans hypothetical protein 0.0157 0.0923 0.1823
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0084 0.0471 0.092
Brugia malayi Cytochrome P450 family protein 0.0012 0.0015 0.0081
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.0067 0.0359 0.0357
Loa Loa (eye worm) calpain family protein 1 0.0045 0.022 0.1212
Trypanosoma cruzi trypanothione reductase, putative 0.0013 0.0021 0.0037
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0043 0.021 0.0196
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.0261 0.1372
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0082 0.0373
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0012 0.0015 0.0081
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0297 0.1806 1
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0062 0.0331 0.1825
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0094 0.053 0.1033
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0067 0.0359 0.1989
Loa Loa (eye worm) hypothetical protein 0.0074 0.0404 0.2233
Schistosoma mansoni cpg binding protein 0.0034 0.0152 0.0137
Trichomonas vaginalis inositol monophosphatase, putative 0.0043 0.021 0.4927
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0222 0.0207
Mycobacterium ulcerans DNA polymerase IV 0.0022 0.0082 0.0134
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0043 0.021 0.0208
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0015 0.0012
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0056 0.0292 0.162
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0022 0.0082 0.0135
Echinococcus multilocularis ubiquitin specific protease 41 0.0043 0.021 0.0208
Loa Loa (eye worm) hypothetical protein 0.0063 0.0339 0.1869
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0012 0.0015 0.0071
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0043 0.021 0.0208
Loa Loa (eye worm) hypothetical protein 0.0012 0.0015 0.0071
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0015 0.0081
Schistosoma mansoni calpain (C02 family) 0.0019 0.0059 0.0045
Schistosoma mansoni survival motor neuron protein 0.0056 0.0292 0.0278
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0074 0.0404 0.0787
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0027 0.0111 0.4709
Loa Loa (eye worm) glutathione reductase 0.0037 0.0173 0.095
Trypanosoma cruzi DNA polymerase eta, putative 0.0052 0.0267 0.141
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0012 0.0015 0.0081
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0222 0.1228
Brugia malayi acetyltransferase, GNAT family protein 0.0161 0.0948 0.5253
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0043 0.021 0.1093
Plasmodium vivax glutathione reductase, putative 0.0037 0.0173 0.3961
Trypanosoma brucei DNA polymerase eta, putative 0.0052 0.0267 0.141
Mycobacterium tuberculosis Probable hydrolase 0.0074 0.0404 0.0787
Loa Loa (eye worm) hypothetical protein 0.0052 0.0267 0.1472
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0082 0.0373
Echinococcus granulosus calpain 7 C02 family 0.0019 0.0059 0.0057
Loa Loa (eye worm) cytochrome P450 family protein 0.0021 0.0076 0.0409
Trypanosoma brucei calpain-like protein, putative 0.0019 0.0059 0.0249
Trypanosoma cruzi cytochrome P450, putative 0.0021 0.0076 0.034
Mycobacterium tuberculosis Probable lipase LipD 0.0074 0.0404 0.0787
Loa Loa (eye worm) hypothetical protein 0.0012 0.0015 0.0071
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0161 0.0948 0.0935
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0012 0.0015 0.0071
Loa Loa (eye worm) hypothetical protein 0.0074 0.0404 0.2233
Loa Loa (eye worm) TK/FAK protein kinase 0.0297 0.1805 1
Onchocerca volvulus 0.0083 0.046 0.8375
Echinococcus granulosus tumor protein p63 0.0393 0.2404 0.2402
Echinococcus granulosus neuropeptide s receptor 0.046 0.2826 0.2824
Loa Loa (eye worm) hypothetical protein 0.0074 0.0404 0.2233
Loa Loa (eye worm) beta-lactamase 0.0074 0.0404 0.2233
Onchocerca volvulus 0.0056 0.0292 0.522
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0012 0.0015 0.0012
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0013 0.0021 0.0014
Loa Loa (eye worm) hypothetical protein 0.0047 0.0237 0.1307
Loa Loa (eye worm) hypothetical protein 0.0012 0.0015 0.0071
Brugia malayi calpain family protein 1 0.0063 0.0339 0.1877
Echinococcus multilocularis hypothetical protein 0.0019 0.0059 0.0057
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0019 0.0059 0.0249
Schistosoma mansoni lamin 0.0083 0.046 0.0446
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0043 0.021 0.0196
Mycobacterium ulcerans beta-lactamase 0.0074 0.0404 0.0782
Schistosoma mansoni tyrosine kinase 0.0294 0.1783 0.1771
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0012 0.0015 0.0071
Echinococcus multilocularis 0.0012 0.0015 0.0012
Trichomonas vaginalis penicillin-binding protein, putative 0.0074 0.0404 1
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0043 0.021 0.1166
Loa Loa (eye worm) hypothetical protein 0.004 0.0192 0.1053
Mycobacterium leprae conserved hypothetical protein 0.0074 0.0404 0.0782
Loa Loa (eye worm) CXXC zinc finger family protein 0.0032 0.014 0.0769
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0047 0.0237 0.5631
Echinococcus multilocularis inositol monophosphatase 1 0.0043 0.021 0.0208
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.021 0.4935
Leishmania major cytochrome p450-like protein 0.0021 0.0076 0.034
Loa Loa (eye worm) hypothetical protein 0.0012 0.0015 0.0071
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0074 0.0404 0.0787
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0067 0.0363 0.0703
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0043 0.021 0.0208
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0019 0.0059 0.0249
Echinococcus granulosus calpain 0.0019 0.0059 0.0057
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0074 0.0404 0.0782
Brugia malayi ImpB/MucB/SamB family protein 0.0052 0.0267 0.1481
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0047 0.0237 0.0235
Brugia malayi beta-lactamase family protein 0.0074 0.0404 0.2241
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0019 0.0059 0.0249
Loa Loa (eye worm) intermediate filament protein 0.0083 0.046 0.2544
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0012 0.0015 0.0081
Echinococcus multilocularis microtubule associated protein 2 0.1604 1 1
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0067 0.0363 0.036
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0222 0.0219
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0141 0.0824 0.4516
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0019 0.0059 0.0249
Loa Loa (eye worm) hypothetical protein 0.0045 0.022 0.1212
Schistosoma mansoni calpain C (C02 family) 0.0019 0.0059 0.0045
Trichomonas vaginalis DNA polymerase eta, putative 0.0022 0.0082 0.1571
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0149 0.0878 0.4865
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0203 0.1052
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0013 0.0021 0.0037
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0042 0.0203 0.0201
Echinococcus granulosus lamin dm0 0.0083 0.046 0.0458
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0022 0.0082 0.0442
Onchocerca volvulus 0.0045 0.022 0.3866
Mycobacterium tuberculosis Conserved hypothetical protein 0.0157 0.0923 0.1834
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0472 0.2902 0.5827
Echinococcus multilocularis ecdysone induced protein 78C 0.0012 0.0015 0.0012
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0015 0.0081
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0027 0.0111 0.248
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0074 0.0404 0.0787
Loa Loa (eye worm) hypothetical protein 0.0275 0.1664 0.9222
Leishmania major trypanothione reductase 0.0037 0.0173 0.0885
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0022 0.0082 0.1571
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0222 0.0207
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0012 0.0015 0.0081
Loa Loa (eye worm) histone methyltransferase 0.001 0.0003 0.0005
Mycobacterium ulcerans lipase LipD 0.0074 0.0404 0.0782
Echinococcus multilocularis thyroid hormone receptor alpha 0.0012 0.0015 0.0012
Loa Loa (eye worm) hypothetical protein 0.0074 0.0404 0.2233
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0038 0.0182 0.0335
Schistosoma mansoni hypothetical protein 0.0047 0.0237 0.0223
Loa Loa (eye worm) steroid hormone receptor 0.0012 0.0015 0.0071
Mycobacterium leprae conserved hypothetical protein 0.0027 0.0111 0.0194
Echinococcus multilocularis GPCR, family 2 0.0047 0.0237 0.0235
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0043 0.021 0.1091
Entamoeba histolytica hypothetical protein 0.0042 0.0203 0.9394

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 0.057 uM Cytotoxicity against human K562 cells after 5 days by MTT assay ChEMBL. 18396050
IC50 (binding) > 20 uM Inhibition of pig brain tubulin polymerization ChEMBL. 18396050

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 18396050

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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