Detailed information for compound 1013875

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 436.455 | Formula: C28H20O5
  • H donors: 3 H acceptors: 4 LogP: 5.67 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Oc1ccc(cc1)c1oc2cc(O)c(cc2c(=O)c1Cc1ccc(cc1)c1ccccc1)O
  • InChi: 1S/C28H20O5/c29-21-12-10-20(11-13-21)28-23(27(32)22-15-24(30)25(31)16-26(22)33-28)14-17-6-8-19(9-7-17)18-4-2-1-3-5-18/h1-13,15-16,29-31H,14H2
  • InChiKey: STHKIFKPJCKJAJ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens protein tyrosine phosphatase, non-receptor type 1 Starlite/ChEMBL References
Homo sapiens acid phosphatase 1, soluble Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) phosphotyrosine protein phosphatase Get druggable targets OG5_127571 All targets in OG5_127571
Echinococcus multilocularis tyrosine protein phosphatase non receptor type Get druggable targets OG5_133865 All targets in OG5_133865
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative Get druggable targets OG5_127571 All targets in OG5_127571
Brugia malayi Low molecular weight phosphotyrosine protein phosphatase containing protein Get druggable targets OG5_127571 All targets in OG5_127571
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative Get druggable targets OG5_127571 All targets in OG5_127571
Candida albicans 3' exon of potential Low molecular weight phosphoTyrosine Phosphatase gene Get druggable targets OG5_127571 All targets in OG5_127571
Schistosoma japonicum expressed protein Get druggable targets OG5_133865 All targets in OG5_133865
Echinococcus granulosus tyrosine protein phosphatase non receptor type Get druggable targets OG5_133865 All targets in OG5_133865
Schistosoma japonicum ko:K05696 protein tyrosine phosphatase, non-receptor type 1, putative Get druggable targets OG5_133865 All targets in OG5_133865
Brugia malayi Protein-tyrosine phosphatase containing protein Get druggable targets OG5_133865 All targets in OG5_133865
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative Get druggable targets OG5_127571 All targets in OG5_127571
Giardia lamblia Low molecular weight protein-tyrosine-phosphatase Get druggable targets OG5_127571 All targets in OG5_127571
Loa Loa (eye worm) protein-tyrosine phosphatase Get druggable targets OG5_133865 All targets in OG5_133865
Schistosoma mansoni protein tyrosine phosphatase non-receptor type nt1 Get druggable targets OG5_133865 All targets in OG5_133865
Mycobacterium tuberculosis Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase) Get druggable targets OG5_127571 All targets in OG5_127571
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative Get druggable targets OG5_127571 All targets in OG5_127571
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative Get druggable targets OG5_127571 All targets in OG5_127571
Onchocerca volvulus Get druggable targets OG5_127571 All targets in OG5_127571
Mycobacterium ulcerans phosphotyrosine protein phosphatase PtpA Get druggable targets OG5_127571 All targets in OG5_127571
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative Get druggable targets OG5_127571 All targets in OG5_127571
Candida albicans C terminus of potential Low molecular weight phosphoTyrosine Phosphatase Get druggable targets OG5_127571 All targets in OG5_127571
Entamoeba histolytica protein tyrosine phosphatase, putative Get druggable targets OG5_127571 All targets in OG5_127571
Entamoeba histolytica protein tyrosine phosphatase, putative Get druggable targets OG5_127571 All targets in OG5_127571
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Mycobacterium tuberculosis Probable acyl-[acyl-carrier protein] desaturase DesA1 (acyl-[ACP] desaturase) (stearoyl-ACP desaturase) (protein Des) acid phosphatase 1, soluble 112 aa 107 aa 24.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0291 0.3339 0.3337
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0186 0.207 0.2068
Schistosoma mansoni protein tyrosine phosphatase non-receptor type nt1 0.0423 0.493 0.4929
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0033 0.0226 0.0263
Brugia malayi jmjC domain containing protein 0.0025 0.0127 0.0148
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0284 0.0282
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0109 0.1145 0.4249
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0038 0.0284 0.033
Schistosoma mansoni hypothetical protein 0.0169 0.1862 0.186
Loa Loa (eye worm) hypothetical protein 0.003 0.0187 0.0218
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0154 0.1691 0.1689
Mycobacterium tuberculosis Probable lipase LipD 0.0038 0.0284 0.004
Schistosoma mansoni inositol monophosphatase 0.0109 0.1145 0.1143
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0045 0.0369 0.2052
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0291 0.3339 0.3337
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0129 0.1383 0.1381
Schistosoma mansoni hypothetical protein 0.0169 0.1862 0.186
Schistosoma mansoni hypothetical protein 0.0148 0.1617 0.1615
Echinococcus multilocularis snurportin 1 0.0303 0.3483 0.3482
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0109 0.1145 0.5471
Loa Loa (eye worm) hypothetical protein 0.0038 0.0284 0.033
Treponema pallidum NADH oxidase 0.0045 0.0369 1
Mycobacterium ulcerans hypothetical protein 0.0038 0.0284 0.0061
Echinococcus multilocularis muscleblind protein 1 0.0147 0.1602 0.16
Leishmania major hypothetical protein, conserved 0.0038 0.0284 0.0937
Onchocerca volvulus 0.0148 0.1617 0.178
Brugia malayi Low molecular weight phosphotyrosine protein phosphatase containing protein 0.0226 0.2551 0.2967
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0171 0.0169
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0568 0.0566
Echinococcus granulosus JmjC domain containing protein 4 0.0025 0.0127 0.0125
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0037 0.027 0.0863
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0025 0.0127 0.0125
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0109 0.1145 0.8096
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0038 0.0284 0.004
Onchocerca volvulus 0.0226 0.2551 0.2913
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0109 0.1145 0.8096
Brugia malayi CHD4 protein 0.0014 0.0002 0.0003
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0037 0.027 0.1278
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0045 0.0369 0.1917
Echinococcus granulosus smad 0.0024 0.0123 0.012
Schistosoma mansoni chromobox protein 0.0067 0.0642 0.064
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0045 0.0369 0.0367
Onchocerca volvulus 0.0147 0.1601 0.1761
Echinococcus granulosus histone lysine methyltransferase setb 0.0091 0.0922 0.092
Echinococcus granulosus beta LACTamase domain containing family member 0.0038 0.0284 0.0282
Schistosoma mansoni cpg binding protein 0.0063 0.0583 0.0581
Schistosoma mansoni cpg binding protein 0.0063 0.0583 0.0581
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0086 0.0861 0.0986
Brugia malayi beta-lactamase family protein 0.0038 0.0284 0.033
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0171 0.0344
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0045 0.0369 0.2052
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0045 0.0369 0.5
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0109 0.1145 0.8064
Loa Loa (eye worm) Smad1 0.0024 0.0123 0.0143
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.027 0.113
Loa Loa (eye worm) hypothetical protein 0.0123 0.1313 0.1527
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0037 0.027 0.0268
Mycobacterium tuberculosis Probable esterase LipL 0.0038 0.0284 0.004
Schistosoma mansoni jumonji domain containing protein 0.0025 0.0127 0.0125
Loa Loa (eye worm) hypothetical protein 0.003 0.0186 0.0216
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0045 0.0369 0.1917
Brugia malayi MH1 domain containing protein 0.0024 0.0123 0.0143
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0024 0.0123 0.0104
Schistosoma mansoni chromobox protein 0.0067 0.0642 0.064
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0148 0.1617 0.1881
Echinococcus multilocularis tar DNA binding protein 0.0061 0.0568 0.0566
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0018 0.0046 0.0043
Plasmodium vivax thioredoxin reductase, putative 0.0129 0.1389 1
Giardia lamblia Histone acetyltransferase GCN5 0.0079 0.0775 0.2485
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0024 0.0123 0.0104
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0568 0.0566
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0284 0.1386
Brugia malayi exodeoxyribonuclease III family protein 0.0037 0.027 0.0314
Toxoplasma gondii NADPH-glutathione reductase 0.0045 0.0369 0.1288
Plasmodium falciparum histone acetyltransferase GCN5 0.0079 0.0775 0.513
Entamoeba histolytica acetyltransferase, GNAT family 0.0079 0.0775 0.2735
Plasmodium falciparum glutathione reductase 0.0045 0.0369 0.1917
Schistosoma mansoni phosphatidylserine receptor 0.0025 0.0127 0.0125
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0295 0.3389 0.887
Loa Loa (eye worm) MH1 domain-containing protein 0.0024 0.0123 0.0143
Echinococcus multilocularis Smad4 0.0024 0.0123 0.012
Echinococcus multilocularis lamin dm0 0.0027 0.0149 0.0146
Schistosoma mansoni inositol monophosphatase 0.0109 0.1145 0.1143
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0319 0.0338
Schistosoma mansoni protein phosphatase 2C 0.0025 0.0127 0.0125
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0038 0.0284 0.004
Brugia malayi hypothetical protein 0.0036 0.026 0.0303
Loa Loa (eye worm) heterochromatin protein 1 0.0067 0.0642 0.0747
Echinococcus multilocularis smad 0.0024 0.0123 0.012
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.026 0.0258
Schistosoma mansoni survival motor neuron protein 0.0148 0.1617 0.1615
Loa Loa (eye worm) hypothetical protein 0.0728 0.8598 1
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0061 0.0568 0.0661
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0045 0.0369 0.1917
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0024 0.0123 0.0104
Plasmodium falciparum ataxin-2 like protein, putative 0.0049 0.0423 0.2345
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0037 0.027 0.035
Mycobacterium tuberculosis Probable hydrolase 0.0038 0.0284 0.004
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0423 0.493 0.5734
Schistosoma mansoni jumonji/arid domain-containing protein 0.0096 0.099 0.0988
Schistosoma mansoni hypothetical protein 0.003 0.0187 0.0185
Loa Loa (eye worm) hypothetical protein 0.0026 0.0143 0.0166
Brugia malayi jmjC domain containing protein 0.0025 0.0127 0.0148
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0037 0.027 0.0314
Echinococcus multilocularis phd:f box containing protein 0.0025 0.0127 0.0125
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0106 0.0083
Trypanosoma brucei low molecular weight protein tyrosine phosphatase, putative 0.007 0.0668 0.4282
Loa Loa (eye worm) glutathione reductase 0.0129 0.1389 0.1616
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0181 0.2005 0.4935
Schistosoma mansoni smad1 5 8 and 0.0024 0.0123 0.012
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0186 0.207 0.2407
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0091 0.0922 0.092
Entamoeba histolytica hypothetical protein 0.0036 0.026 0.0631
Trichomonas vaginalis bromodomain-containing protein, putative 0.0086 0.0861 0.0986
Brugia malayi Smad1 0.0024 0.0123 0.0143
Loa Loa (eye worm) inositol-1 0.0109 0.1145 0.1332
Brugia malayi jmjC domain containing protein 0.0025 0.0127 0.0148
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.027 0.113
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0568 0.0566
Brugia malayi glutathione reductase 0.0129 0.1389 0.1616
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0295 0.3389 0.887
Leishmania major hypothetical protein, conserved 0.0025 0.0127 0.0113
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0171 0.0344
Echinococcus granulosus TGF beta signal transducer SmadC 0.0024 0.0123 0.012
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0086 0.0861 0.5812
Loa Loa (eye worm) beta-lactamase 0.0038 0.0284 0.033
Schistosoma mansoni lamin 0.0027 0.0149 0.0146
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.007 0.0668 0.0755
Trypanosoma cruzi hypothetical protein, conserved 0.007 0.0668 0.4378
Brugia malayi Pre-SET motif family protein 0.0625 0.7359 0.8559
Onchocerca volvulus 0.0102 0.1055 0.1099
Schistosoma mansoni hypothetical protein 0.0036 0.026 0.0258
Onchocerca volvulus 0.003 0.0186 0.0045
Echinococcus granulosus Smad4 0.0024 0.0123 0.012
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0109 0.1145 0.1326
Loa Loa (eye worm) jmjC domain-containing protein 0.0025 0.0127 0.0148
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0045 0.0369 0.2052
Echinococcus granulosus survival motor neuron protein 1 0.0728 0.8598 0.8598
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0106 0.0083
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0024 0.0123 0.0104
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0045 0.0369 0.0435
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0038 0.0284 0.033
Echinococcus multilocularis survival motor neuron protein 1 0.0728 0.8598 0.8598
Loa Loa (eye worm) PHD-finger family protein 0.003 0.0187 0.0218
Echinococcus granulosus lamin dm0 0.0027 0.0149 0.0146
Brugia malayi MH2 domain containing protein 0.0024 0.0123 0.0143
Brugia malayi acetyltransferase, GNAT family protein 0.0291 0.3339 0.3883
Echinococcus multilocularis mothers against decapentaplegic 5 0.0024 0.0123 0.012
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0086 0.0861 0.3906
Plasmodium vivax hypothetical protein, conserved 0.0038 0.0284 0.124
Schistosoma mansoni Smad4 0.0024 0.0123 0.012
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0109 0.1145 0.3835
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.027 0.0279
Brugia malayi PHD-finger family protein 0.003 0.0187 0.0218
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0186 0.207 0.2068
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0022 0.0089 0.0087
Mycobacterium tuberculosis Probable oxidoreductase 0.0328 0.3786 1
Toxoplasma gondii thioredoxin reductase 0.0129 0.1389 0.672
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0285 0.0297
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0187 0.0319
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0186 0.207 0.2068
Brugia malayi intermediate filament protein 0.0027 0.0149 0.0173
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0045 0.0369 0.1917
Brugia malayi jmjC domain containing protein 0.0096 0.099 0.1152
Brugia malayi Heterochromatin protein 1 0.0067 0.0642 0.0747
Schistosoma mansoni hypothetical protein 0.0303 0.3483 0.3482
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0018 0.0046 0.0043
Plasmodium falciparum ataxin-2 like protein, putative 0.0049 0.0423 0.2345
Onchocerca volvulus Huntingtin homolog 0.0123 0.1313 0.1411
Trypanosoma cruzi trypanothione reductase, putative 0.0129 0.1389 1
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0328 0.3786 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.0284 0.033
Loa Loa (eye worm) hypothetical protein 0.0049 0.0423 0.0492
Schistosoma mansoni hypothetical protein 0.0022 0.0095 0.0093
Mycobacterium ulcerans aldehyde dehydrogenase 0.0181 0.2005 0.7606
Brugia malayi F/Y-rich N-terminus family protein 0.0031 0.0204 0.0237
Mycobacterium tuberculosis Conserved protein 0.0038 0.0284 0.004
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0149 0.0173
Echinococcus granulosus PHD finger protein rhinoceros 0.003 0.0187 0.0185
Echinococcus granulosus jumonji domain containing protein 0.0041 0.0328 0.0326
Brugia malayi hypothetical protein 0.0032 0.0213 0.0247
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0086 0.0867 0.0865
Loa Loa (eye worm) hypothetical protein 0.0066 0.0627 0.0729
Mycobacterium tuberculosis Conserved protein 0.0038 0.0284 0.004
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0284 0.0296
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0241 0.2738 0.702
Onchocerca volvulus Alhambra homolog 0.003 0.0187 0.0047
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0024 0.0123 0.0104
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0154 0.1691 0.1689
Loa Loa (eye worm) transcription factor SMAD2 0.0358 0.4144 0.482
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0086 0.0861 0.3906
Trypanosoma brucei PAB1-binding protein , putative 0.0049 0.0423 0.2345
Giardia lamblia NADH oxidase lateral transfer candidate 0.0045 0.0369 0.077
Loa Loa (eye worm) hypothetical protein 0.0038 0.0284 0.033
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0038 0.0285 0.0165
Echinococcus granulosus snurportin 1 0.0303 0.3483 0.3482
Mycobacterium ulcerans esterase/lipase LipP 0.0038 0.0284 0.0061
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0045 0.0369 0.1917
Mycobacterium tuberculosis Probable dehydrogenase 0.0295 0.3389 0.887
Schistosoma mansoni aldehyde dehydrogenase 0.0181 0.2005 0.2003
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0024 0.0123 0.0104
Echinococcus granulosus lysine specific demethylase 6a 0.0025 0.0127 0.0125
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0091 0.0922 0.4231
Schistosoma mansoni jumonji/arid domain-containing protein 0.0096 0.099 0.0988
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0022 0.0095 0.0093
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0181 0.2005 0.2003
Plasmodium falciparum importin beta, putative 0.0028 0.0171 0.0344
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0186 0.207 0.2068
Brugia malayi Pre-SET motif family protein 0.0091 0.0922 0.1072
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0284 0.0296
Mycobacterium ulcerans phosphotyrosine protein phosphatase PtpA 0.0226 0.2551 1
Loa Loa (eye worm) hypothetical protein 0.0091 0.0922 0.1072
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0295 0.3389 0.887
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0226 0.2551 0.3008
Toxoplasma gondii exonuclease III APE 0.0037 0.027 0.0759
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0022 0.0095 0.0093
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0041 0.0319 0.0207
Loa Loa (eye worm) MH2 domain-containing protein 0.0024 0.0123 0.0143
Schistosoma mansoni phd/f-box containing protein 0.0025 0.0127 0.0125
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0018 0.0046 0.0043
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0091 0.0922 0.092
Loa Loa (eye worm) hypothetical protein 0.0038 0.0285 0.0331
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0045 0.0369 0.0435
Mycobacterium ulcerans lipase LipD 0.0038 0.0284 0.0061
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0045 0.0369 0.1386
Loa Loa (eye worm) jmjC domain-containing protein 0.0061 0.057 0.0662
Brugia malayi Bromodomain containing protein 0.0037 0.0273 0.0318
Schistosoma mansoni aldehyde dehydrogenase 0.0181 0.2005 0.2003
Brugia malayi Importin beta-1 subunit 0.0028 0.0171 0.0199
Brugia malayi MH1 domain containing protein 0.0024 0.0123 0.0143
Trypanosoma cruzi PAB1-binding protein , putative 0.0049 0.0423 0.2472
Echinococcus multilocularis lamin 0.0027 0.0149 0.0146
Brugia malayi RNA, U transporter 1 0.0081 0.0802 0.0933
Loa Loa (eye worm) hypothetical protein 0.0147 0.1602 0.1863
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0091 0.0922 0.092
Schistosoma mansoni smad1 5 8 and 0.0024 0.0123 0.012
Brugia malayi SET domain containing protein 0.0016 0.0017 0.002
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0284 0.1386
Echinococcus multilocularis jumonji domain containing protein 0.0041 0.0328 0.0326
Toxoplasma gondii aldehyde dehydrogenase 0.0181 0.2005 1
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0285 0.0297
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0024 0.0123 0.0104
Loa Loa (eye worm) CXXC zinc finger family protein 0.0059 0.0543 0.0631
Brugia malayi TAR-binding protein 0.0061 0.0568 0.0661
Echinococcus multilocularis geminin 0.0169 0.1862 0.186
Schistosoma mansoni hypothetical protein 0.0844 1 1
Schistosoma mansoni importin beta-1 0.0028 0.0171 0.0169
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0226 0.2551 1
Schistosoma mansoni ap endonuclease 0.0037 0.027 0.0268
Onchocerca volvulus 0.0711 0.8397 1
Plasmodium falciparum phd finger protein, putative 0.003 0.0187 0.0475
Brugia malayi jmjC domain containing protein 0.0025 0.0127 0.0148
Loa Loa (eye worm) jmjC domain-containing protein 0.0025 0.0127 0.0148
Loa Loa (eye worm) hypothetical protein 0.0147 0.1602 0.1863
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0045 0.0369 0.2052
Trypanosoma brucei hypothetical protein, conserved 0.0038 0.0284 0.124
Schistosoma mansoni smad 0.0024 0.0123 0.012
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0423 0.493 0.5734
Plasmodium falciparum thioredoxin reductase 0.0045 0.0369 0.1917
Echinococcus multilocularis chromobox protein 1 0.0067 0.0642 0.064
Onchocerca volvulus 0.0038 0.0284 0.0164
Trichomonas vaginalis chromobox protein, putative 0.0067 0.0642 0.0724
Plasmodium vivax hypothetical protein, conserved 0.003 0.0187 0.0475
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0045 0.0369 0.1386
Trypanosoma brucei trypanothione reductase 0.0129 0.1389 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0358 0.4144 0.482
Loa Loa (eye worm) hypothetical protein 0.0123 0.1313 0.1527
Echinococcus granulosus tar DNA binding protein 0.0061 0.0568 0.0566
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0186 0.207 0.2068
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0186 0.207 0.2407
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0038 0.0284 0.004
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0028 0.0163 0.0161
Loa Loa (eye worm) jmjC domain-containing protein 0.0096 0.099 0.1152
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0423 0.493 0.4929
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0022 0.0089 0.0087
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0284 0.0296
Loa Loa (eye worm) thioredoxin reductase 0.0129 0.1389 0.1616
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0226 0.2551 0.3008
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0319 0.0338
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0109 0.1145 0.5419
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0102 0.1055 0.1053
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0129 0.1389 0.3183
Echinococcus granulosus mothers against decapentaplegic 5 0.0024 0.0123 0.012
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0186 0.207 0.2068
Echinococcus granulosus peregrin 0.0037 0.0273 0.0271
Trypanosoma cruzi hypothetical protein, conserved 0.007 0.0668 0.4378
Trichomonas vaginalis esterase, putative 0.0038 0.0284 0.0296
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0028 0.0168 0.0166
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0033 0.0226 0.0263
Echinococcus multilocularis thioredoxin glutathione reductase 0.013 0.1395 0.1393
Schistosoma mansoni smad1 5 8 and 0.0024 0.0123 0.012
Brugia malayi CXXC zinc finger family protein 0.0059 0.0543 0.0631
Schistosoma mansoni ap endonuclease 0.0037 0.027 0.0268
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.003 0.0187 0.0185
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0045 0.0369 0.043
Brugia malayi hypothetical protein 0.0147 0.1601 0.1862
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0284 0.0282
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0025 0.0127 0.0167
Trypanosoma cruzi trypanothione reductase, putative 0.0045 0.0369 0.2052
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0226 0.2551 0.3008
Loa Loa (eye worm) acetyltransferase 0.0291 0.3339 0.3883
Echinococcus granulosus intermediate filament protein 0.0027 0.0149 0.0146
Loa Loa (eye worm) hypothetical protein 0.0038 0.0284 0.033
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0038 0.0284 0.0061
Loa Loa (eye worm) hypothetical protein 0.0027 0.0149 0.0173
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0284 0.0296
Trichomonas vaginalis glutathione reductase, putative 0.0045 0.0369 0.0398
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.026 0.0258
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0295 0.3389 0.887
Brugia malayi hypothetical protein 0.0049 0.0423 0.0492
Brugia malayi hypothetical protein 0.0728 0.8598 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.0284 0.033
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0187 0.0319
Schistosoma mansoni lamin 0.0027 0.0149 0.0146
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0284 0.0296
Onchocerca volvulus 0.0038 0.0284 0.0164
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0186 0.207 0.2068
Echinococcus granulosus muscleblind protein 0.0147 0.1602 0.16
Onchocerca volvulus Huntingtin homolog 0.0123 0.1313 0.1411
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0091 0.0922 0.092
Brugia malayi Muscleblind-like protein 0.0147 0.1602 0.1863
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0109 0.1145 1
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0045 0.0369 0.1135
Mycobacterium ulcerans aldehyde dehydrogenase 0.0181 0.2005 0.7606
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.027 0.0279
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0024 0.0123 0.0104
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0037 0.027 0.0268
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0226 0.2551 0.3008
Mycobacterium tuberculosis Probable reductase 0.0295 0.3389 0.887
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0423 0.493 0.4929
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0024 0.0123 0.012
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0149 0.0173
Schistosoma mansoni intermediate filament proteins 0.0027 0.0149 0.0146
Leishmania major hypothetical protein, conserved 0.0049 0.0423 0.1671
Brugia malayi Thioredoxin reductase 0.0129 0.1389 0.1616
Loa Loa (eye worm) hypothetical protein 0.0028 0.0171 0.0199
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.026 0.0258
Echinococcus multilocularis lysine specific demethylase 6a 0.0025 0.0127 0.0125
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0018 0.0048 0.0014
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0025 0.0127 0.0167
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0181 0.2005 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.0127 0.0148
Brugia malayi RNA recognition motif domain containing protein 0.0061 0.0568 0.0661
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0568 0.0566
Brugia malayi Inositol-1 0.0109 0.1145 0.1332
Loa Loa (eye worm) hypothetical protein 0.0025 0.0127 0.0148
Echinococcus granulosus inositol monophosphatase 1 0.0109 0.1145 0.1143
Mycobacterium tuberculosis Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase) 0.0156 0.1712 0.4101
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0045 0.0369 0.2052
Echinococcus granulosus histone acetyltransferase KAT2B 0.0086 0.0861 0.0859
Echinococcus multilocularis dnaJ subfamily B 0.0844 1 1
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0226 0.2551 0.3008
Echinococcus granulosus jumonji domain containing 1A 0.0025 0.0127 0.0125
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0045 0.0369 0.2052
Echinococcus multilocularis jumonji domain containing 1A 0.0025 0.0127 0.0125
Echinococcus granulosus importin subunit beta 1 0.0028 0.0171 0.0169
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0226 0.2551 0.3008
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0303 0.3483 0.4051
Brugia malayi beta-lactamase 0.0038 0.0284 0.033
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0109 0.1145 0.1326
Leishmania major trypanothione reductase 0.0129 0.1389 0.6757
Onchocerca volvulus 0.0038 0.0284 0.0164
Brugia malayi hypothetical protein 0.0123 0.1313 0.1527
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0045 0.0369 0.1917
Onchocerca volvulus 0.0059 0.0543 0.0478
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0037 0.027 0.067
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0151 0.0137
Echinococcus granulosus lysine specific demethylase 5A 0.0096 0.099 0.0988
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0045 0.0369 0.1917
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0045 0.0369 0.0435
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0151 0.0137
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0045 0.0369 0.2052
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0091 0.0922 0.092
Echinococcus multilocularis PHD finger protein rhinoceros 0.003 0.0187 0.0185
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0045 0.0369 0.1386
Trichomonas vaginalis inositol monophosphatase, putative 0.0109 0.1145 0.1326
Echinococcus granulosus mixed lineage leukemia protein mll 0.0018 0.0046 0.0043
Loa Loa (eye worm) RNA binding protein 0.0061 0.0568 0.0661
Plasmodium falciparum glutathione reductase 0.0129 0.1389 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.0284 0.033
Trichomonas vaginalis mercuric reductase, putative 0.0045 0.0369 0.0398
Loa Loa (eye worm) TAR-binding protein 0.0061 0.0568 0.0661
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0037 0.027 0.1278
Mycobacterium tuberculosis Probable lipase LipE 0.0038 0.0284 0.004
Mycobacterium ulcerans beta-lactamase 0.0038 0.0284 0.0061
Mycobacterium tuberculosis Conserved protein 0.0038 0.0284 0.004
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0106 0.0083
Entamoeba histolytica hypothetical protein 0.0036 0.026 0.0631
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0045 0.0369 0.1135
Loa Loa (eye worm) hypothetical protein 0.0147 0.1601 0.1862
Trichomonas vaginalis set domain proteins, putative 0.0711 0.8397 1
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0226 0.2551 1
Echinococcus multilocularis peregrin 0.0037 0.0273 0.0271
Brugia malayi chromobox protein homolog 3 0.0038 0.0285 0.0331
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0098 0.1007 0.2065
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0295 0.3389 0.8866
Echinococcus multilocularis chromobox protein 1 0.0067 0.0642 0.064
Loa Loa (eye worm) CHromoDomain protein family member 0.0014 0.0002 0.0003
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0171 0.0231
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0045 0.0369 0.1386
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.007 0.0668 0.0755
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0045 0.0369 0.2052
Echinococcus multilocularis JmjC domain containing protein 4 0.0025 0.0127 0.0125
Echinococcus granulosus chromobox protein 1 0.0067 0.0642 0.064
Toxoplasma gondii histone lysine methyltransferase SET1 0.0123 0.1307 0.6283
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0045 0.0369 0.1288
Echinococcus granulosus geminin 0.0169 0.1862 0.186
Echinococcus multilocularis lysine specific demethylase 5A 0.0093 0.095 0.0948
Mycobacterium ulcerans aldehyde dehydrogenase 0.0181 0.2005 0.7606
Giardia lamblia Low molecular weight protein-tyrosine-phosphatase 0.0226 0.2551 1
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0568 0.0566
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0045 0.0369 0.0282
Brugia malayi MH2 domain containing protein 0.0024 0.0123 0.0143
Toxoplasma gondii LsmAD domain-containing protein 0.0049 0.0423 0.1576
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0028 0.0168 0.0166
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0328 0.3786 1
Trichomonas vaginalis chromobox protein, putative 0.0067 0.0642 0.0724
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0181 0.2005 0.2003
Echinococcus granulosus thioredoxin glutathione reductase 0.013 0.1395 0.1393
Brugia malayi beta-lactamase family protein 0.0038 0.0284 0.033
Plasmodium vivax SET domain protein, putative 0.0091 0.0922 0.6296
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0045 0.0369 0.1917
Plasmodium vivax ataxin-2 like protein, putative 0.0049 0.0423 0.2345
Entamoeba histolytica hypothetical protein 0.0036 0.026 0.0631
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0045 0.0369 0.0367
Brugia malayi MH2 domain containing protein 0.0358 0.4144 0.482
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0625 0.7359 0.8559
Echinococcus multilocularis muscleblind protein 0.0147 0.1602 0.16
Schistosoma mansoni jumonji domain containing protein 0.0134 0.1449 0.1447
Schistosoma mansoni cpg binding protein 0.0059 0.0543 0.054
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0024 0.0123 0.012
Echinococcus granulosus chromobox protein 1 0.0067 0.0642 0.064
Loa Loa (eye worm) histone methyltransferase 0.0022 0.0089 0.0104
Plasmodium falciparum thioredoxin reductase 0.0129 0.1389 1
Leishmania major hypothetical protein, conserved 0.007 0.0668 0.2958
Echinococcus granulosus phd:f box containing protein 0.0025 0.0127 0.0125
Brugia malayi jmjC domain containing protein 0.0154 0.1691 0.1966
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0149 0.0173
Toxoplasma gondii ABC1 family protein 0.0038 0.0284 0.0833
Echinococcus multilocularis cpg binding protein 0.0063 0.0583 0.0581
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0037 0.027 0.113
Loa Loa (eye worm) phosphotyrosine protein phosphatase 0.0226 0.2551 0.2967
Echinococcus multilocularis beta LACTamase domain containing family member 0.0038 0.0284 0.0282
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0045 0.0369 0.0367
Trypanosoma cruzi PAB1-binding protein , putative 0.0049 0.0423 0.2472
Brugia malayi RNA binding protein 0.0061 0.0568 0.0661
Echinococcus granulosus cpg binding protein 0.0063 0.0583 0.0581
Echinococcus multilocularis inositol monophosphatase 1 0.0109 0.1145 0.1143
Entamoeba histolytica hypothetical protein 0.0036 0.026 0.0631
Loa Loa (eye worm) jmjC domain-containing protein 0.0025 0.0127 0.0148
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0098 0.1007 0.2096
Echinococcus multilocularis musashi 0.0027 0.0149 0.0146
Plasmodium vivax importin-beta 2, putative 0.0028 0.0171 0.0344
Echinococcus granulosus lamin 0.0027 0.0149 0.0146
Plasmodium vivax glutathione reductase, putative 0.0129 0.1389 1
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0328 0.3786 1
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0048 0.0014
Echinococcus granulosus histone acetyltransferase KAT2B 0.0283 0.3241 0.3239

Activities

Activity type Activity value Assay description Source Reference
Activity (binding) Activation of human insulin receptor beta expressed in human HepG2 cells assessed as increase in tyrosine phosphorylation level at 10 uM after 90 mins by SDS-PAGE ChEMBL. 19297174
Activity (binding) Activation of human insulin receptor beta expressed in human HepG2 cells assessed as stimulation of receptor phosphorylation at 10 uM after 90 mins by SDS-PAGE ChEMBL. 19297174
IC50 (binding) = 1.1 uM Inhibition of human cloned LMW-PTP isoform 1 expressed in Escherichia coli TB1 ChEMBL. 19297174
IC50 (binding) = 2 uM Inhibition of human cloned PTP1B expressed in Escherichia coli TB1 ChEMBL. 19297174
IC50 (binding) = 3 uM Inhibition of human cloned LMW-PTP isoform 2 expressed in Escherichia coli TB1 ChEMBL. 19297174
Ki (binding) Inhibition of human cloned PTP1B expressed in Escherichia coli TB1 by competitive inhibition assay ChEMBL. 19297174
Ki (binding) = 0.27 uM Inhibition of human cloned LMW-PTP isoform 1 expressed in Escherichia coli TB1 by competitive inhibition assay ChEMBL. 19297174
Ki (binding) = 0.34 uM Inhibition of human cloned LMW-PTP isoform 2 expressed in Escherichia coli TB1 by competitive inhibition assay ChEMBL. 19297174

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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