Detailed information for compound 1025035

Basic information

Technical information
  • TDR Targets ID: 1025035
  • Name: [(2S,3S,4R,4aS,4bS,5R,6S,7S,8aR,9R,10aS)-3,9- diacetyloxy-5-(benzoyloxy)-6-ethenyl-2,7,8a-t rihydroxy-1,1,4a,7-tetramethyl-8-oxo-3,4,4b,5 ,6,9,10,10a-octahydro-2H-phenanthren-4-yl] be nzoate
  • MW: 692.749 | Formula: C38H44O12
  • H donors: 3 H acceptors: 8 LogP: 4.27 Rotable bonds: 11
    Rule of 5 violations (Lipinski): 2
  • SMILES: C=C[C@H]1[C@@H](OC(=O)c2ccccc2)[C@@H]2[C@@]3(C)[C@@H](OC(=O)c4ccccc4)[C@@H](OC(=O)C)[C@H](C([C@@H]3C[C@H]([C@]2(C(=O)[C@@]1(C)O)O)OC(=O)C)(C)C)O
  • InChi: 1S/C38H44O12/c1-8-24-27(49-32(42)22-15-11-9-12-16-22)29-36(6)25(19-26(47-20(2)39)38(29,46)34(44)37(24,7)45)35(4,5)30(41)28(48-21(3)40)31(36)50-33(43)23-17-13-10-14-18-23/h8-18,24-31,41,45-46H,1,19H2,2-7H3/t24-,25-,26+,27+,28-,29+,30+,31-,36-,37-,38-/m0/s1
  • InChiKey: PBUZGANPVDYQRM-FRZINCLTSA-N  


Substructure search Similarity search

Network

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Synonyms

  • [(2S,3S,4R,4aS,4bS,5R,6S,7S,8aR,9R,10aS)-3,9-diacetoxy-5-(benzoyloxy)-2,7,8a-trihydroxy-1,1,4a,7-tetramethyl-8-oxo-6-vinyl-3,4,4b,5,6,9,10,10a-octahydro-2H-phenanthren-4-yl] benzoate
  • benzoic acid [(2S,3S,4R,4aS,4bS,5R,6S,7S,8aR,9R,10aS)-3,9-diacetoxy-2,7,8a-trihydroxy-1,1,4a,7-tetramethyl-8-oxo-5-(oxo-phenylmethoxy)-6-vinyl-3,4,4b,5,6,9,10,10a-octahydro-2H-phenanthren-4-yl] ester
  • benzoic acid [(2S,3S,4R,4aS,4bS,5R,6S,7S,8aR,9R,10aS)-3,9-diacetoxy-5-(benzoyloxy)-2,7,8a-trihydroxy-8-keto-1,1,4a,7-tetramethyl-6-vinyl-3,4,4b,5,6,9,10,10a-octahydro-2H-phenanthren-4-yl] ester
  • [(2S,3S,4R,4aS,4bS,5R,6S,7S,8aR,9R,10aS)-3,9-diacetyloxy-6-ethenyl-2,7,8a-trihydroxy-1,1,4a,7-tetramethyl-8-oxo-5-phenylcarbonyloxy-3,4,4b,5,6,9,10,10a-octahydro-2H-phenanthren-4-yl] benzoate

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis STE family protein kinase 0.0076 0.049 0.1448
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0033 0.0052 0.0134
Loa Loa (eye worm) hypothetical protein 0.0107 0.0802 0.0787
Entamoeba histolytica cell division protein kinase 2, putative 0.0112 0.0854 0.3159
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0116 0.0892 0.3105
Echinococcus multilocularis serine:threonine protein kinase 3 0.0265 0.2388 0.2649
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0112 0.0854 0.0839
Loa Loa (eye worm) CAMK/CAMKL/MELK protein kinase 0.0085 0.058 0.0564
Echinococcus granulosus nervana 2 0.0137 0.1098 0.2769
Entamoeba histolytica protein kinase domain containing protein 0.0116 0.0892 0.3313
Leishmania major protein kinase A catalytic subunit isoform 2 0.0062 0.0345 0.0811
Loa Loa (eye worm) hypothetical protein 0.0039 0.0118 0.0102
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.0059 0.0321 0.0305
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0123 0.0964 0.0949
Echinococcus granulosus protein kinase c iota type 0.0269 0.2429 0.6186
Schistosoma mansoni serine/threonine protein kinase 0.0179 0.1522 0.3888
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0159 0.132 0.4921
Echinococcus granulosus serine:threonine protein kinase 3 0.0265 0.2388 0.6081
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0033 0.0052 0.0036
Echinococcus granulosus protein kinase C gamma type 0.0185 0.1582 0.4012
Giardia lamblia Kinase, PLK 0.028 0.2537 1
Loa Loa (eye worm) hypothetical protein 0.0293 0.267 0.2658
Schistosoma mansoni tyrosine kinase 0.0152 0.1256 0.3208
Echinococcus granulosus rho-associated protein kinase 1 0.034 0.3147 0.8029
Entamoeba histolytica p21-activated kinase 0.0081 0.0536 0.1872
Echinococcus multilocularis serine:threonine protein kinase N2 0.014 0.1128 0.1239
Trypanosoma cruzi casein kinase, putative 0.0059 0.0321 0.075
Schistosoma mansoni serine/threonine protein kinase 0.0062 0.0345 0.0882
Trichomonas vaginalis CMGC family protein kinase 0.0074 0.0465 0.1343
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.0154 0.1274 0.1403
Trichomonas vaginalis STE family protein kinase 0.0132 0.1047 0.3763
Trypanosoma cruzi casein kinase II, putative 0.0092 0.0647 0.2109
Loa Loa (eye worm) hypothetical protein 0.0038 0.0104 0.0088
Loa Loa (eye worm) hypothetical protein 0.0153 0.1266 0.1252
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0371 0.3452 0.3441
Brugia malayi casein kinase 1, delta 0.0059 0.0321 0.0305
Brugia malayi Phorbol esters/diacylglycerol binding domain 0.0146 0.1188 0.1173
Trypanosoma brucei casein kinase I, isoform 2 0.0059 0.0321 0.0706
Entamoeba histolytica protein kinase, putative 0.0142 0.1151 0.4356
Echinococcus multilocularis neuroglian 0.0035 0.0077 0.0064
Trypanosoma brucei cdc2-related kinase 3 0.0112 0.0854 0.2932
Echinococcus granulosus serine:threonine protein kinase MARK2 0.0175 0.1481 0.3753
Echinococcus granulosus RNA directed DNA polymerase 0.0044 0.0165 0.0372
Schistosoma mansoni serine/threonine protein kinase 0.0046 0.0185 0.0472
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.028 0.2537 0.2816
Giardia lamblia Kinase, NEK 0.0132 0.1047 0.3275
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.0142 0.1151 0.4356
Echinococcus granulosus mitogen activated protein kinase 14 0.0157 0.1302 0.3293
Trypanosoma cruzi casein kinase, putative 0.0059 0.0321 0.075
Schistosoma mansoni serine/threonine-protein kinase 0.0159 0.132 0.3373
Giardia lamblia Kinase, NEK 0.0132 0.1047 0.3275
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0197 0.1708 0.4336
Trypanosoma brucei rac serine-threonine kinase, putative 0.0281 0.2547 1
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.0076 0.049 0.0526
Loa Loa (eye worm) hypothetical protein 0.0082 0.0545 0.0529
Plasmodium vivax casein kinase 2, alpha subunit, putative 0.0092 0.0647 0.4862
Entamoeba histolytica PH domain containing protein kinase, putative 0.0066 0.0391 0.1287
Trypanosoma cruzi aurora B kinase, putative 0.0142 0.1151 0.4213
Echinococcus multilocularis epidermal growth factor receptor 0.0073 0.0458 0.049
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0123 0.0964 0.2463
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0179 0.1522 0.1508
Brugia malayi probable protein kinase 0.0029 0.0021 0.0004
Schistosoma mansoni serine/threonine protein kinase 0.0223 0.1962 0.5014
Echinococcus granulosus cyclin dependent kinase 0.0112 0.0854 0.2143
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0123 0.0964 0.1056
Echinococcus granulosus serine:threonine protein kinase N2 0.014 0.1128 0.2844
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.0371 0.3452 0.8812
Toxoplasma gondii CMGC kinase, CK2 family 0.0092 0.0647 0.2426
Loa Loa (eye worm) STE/STE20/PAKB protein kinase 0.0237 0.2113 0.21
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0043 0.0152 0.0148
Schistosoma mansoni serine/threonine protein kinase 0.0417 0.3914 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.0154 0.0138
Trichomonas vaginalis CAMK family protein kinase 0.0085 0.058 0.1822
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0232 0.2062 0.2284
Schistosoma mansoni serine/threonine protein kinase 0.028 0.2537 0.6482
Schistosoma mansoni serine/threonine protein kinase 0.0116 0.0892 0.228
Brugia malayi serine/threonine-protein kinase 6 0.0142 0.1151 0.1136
Echinococcus multilocularis cyclin dependent kinase 1 0.0112 0.0854 0.0933
Echinococcus granulosus p21 activated protein kinase 1 Dpak1 0.0076 0.049 0.1207
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.014 0.1128 0.2844
Brugia malayi P38 map kinase family protein 2 0.0157 0.1302 0.1288
Schistosoma mansoni serine/threonine protein kinase 0.0142 0.1151 0.294
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0029 0.0021 0.0001
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0062 0.0345 0.0835
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0123 0.0964 0.3433
Entamoeba histolytica protein kinase domain containing protein 0.0123 0.0964 0.3602
Brugia malayi protein unc-22 0.0029 0.002 0.0004
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0117 0.0906 0.0991
Echinococcus granulosus PAK box P21 Rho binding 0.0035 0.0073 0.0135
Echinococcus multilocularis protein kinase c iota type 0.0269 0.2429 0.2695
Brugia malayi cAMP-dependent protein kinase catalytic subunit, putative 0.0062 0.0345 0.033
Plasmodium vivax casein kinase 1, putative 0.0059 0.0321 0.2198
Trichomonas vaginalis STE family protein kinase 0.0076 0.049 0.1448
Trypanosoma cruzi cdc2-related kinase 3 0.0112 0.0854 0.2975
Schistosoma mansoni atypical protein kinase C 0.0276 0.2497 0.6378
Schistosoma mansoni protein kinase 0.0052 0.0249 0.0636
Trichomonas vaginalis AGC family protein kinase 0.0132 0.1047 0.3763
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0074 0.0465 0.1349
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 1 0.0062 0.0345 0.0851
Schistosoma mansoni protein kinase 0.0197 0.1708 0.4365
Trichomonas vaginalis CMGC family protein kinase 0.0092 0.0647 0.21
Loa Loa (eye worm) hypothetical protein 0.0038 0.0104 0.0088
Echinococcus multilocularis casein kinase I delta 0.0059 0.0321 0.0337
Trichomonas vaginalis set domain proteins, putative 0.0259 0.2329 0.9091
Schistosoma mansoni serine/threonine protein kinase 0.0112 0.0854 0.2182
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0123 0.0964 0.2424
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 1 0.0062 0.0345 0.0807
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0074 0.0465 0.1349
Trypanosoma cruzi polo-like protein kinase, putative 0.028 0.2537 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0052 0.0134
Echinococcus granulosus raf serine:threonine protein kinase 0.0046 0.0185 0.0423
Trichomonas vaginalis AGC family protein kinase 0.0281 0.2547 1
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0043 0.0152 0.0815
Trichomonas vaginalis CAMK family protein kinase 0.0107 0.0802 0.2746
Brugia malayi Protein kinase domain containing protein 0.0029 0.0021 0.0004
Schistosoma mansoni protein kinase 0.0029 0.0021 0.0053
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.0154 0.1274 0.3222
Trichomonas vaginalis CAMK family protein kinase 0.028 0.2537 0.9957
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0062 0.0345 0.0851
Trypanosoma cruzi casein kinase, putative 0.0059 0.0321 0.075
Loa Loa (eye worm) AGC/AKT protein kinase 0.0281 0.2547 0.2535
Echinococcus multilocularis mitogen activated protein kinase 3 0.0074 0.0465 0.0497
Schistosoma mansoni wiskott-aldrich syndrome protein 0.0035 0.0073 0.0185
Brugia malayi Ras association domain family 1 isoform A 0.0038 0.0104 0.0088
Schistosoma mansoni titin 0.0029 0.002 0.0051
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0142 0.1151 0.1265
Entamoeba histolytica protein kinase, putative 0.0123 0.0964 0.3602
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.0121 0.0939 0.2361
Schistosoma mansoni serine/threonine protein kinase 0.0043 0.0152 0.0388
Schistosoma mansoni serine/threonine kinase 0.0085 0.058 0.1481
Echinococcus granulosus Glutaredoxin protein 5 0.0137 0.1098 0.2769
Entamoeba histolytica protein kinase domain containing protein 0.0092 0.0647 0.2319
Schistosoma mansoni hypothetical protein 0.0068 0.0403 0.103
Entamoeba histolytica casein kinase, putative 0.0059 0.0321 0.1004
Echinococcus multilocularis p21 activated protein kinase 1 Dpak1 0.0076 0.049 0.0526
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0112 0.0854 0.2945
Echinococcus multilocularis hypothetical protein 0.0068 0.0403 0.0429
Entamoeba histolytica PH domain containing protein kinase, putative 0.0066 0.0391 0.1287
Entamoeba histolytica protein kinase domain containing protein 0.0123 0.0964 0.3602
Echinococcus granulosus casein kinase i 0.0059 0.0321 0.0773
Brugia malayi Protein kinase domain containing protein 0.0371 0.3452 0.3441
Schistosoma mansoni tyrosine kinase 0.0065 0.0378 0.0965
Trypanosoma brucei cdc2-related kinase 1 0.0112 0.0854 0.2932
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.0059 0.0321 0.0305
Trichomonas vaginalis STE family protein kinase 0.0075 0.0475 0.1386
Schistosoma mansoni protein kinase 0.0035 0.0073 0.0185
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0116 0.0892 0.3135
Trichomonas vaginalis AGC family protein kinase 0.0142 0.1151 0.4195
Schistosoma mansoni tyrosine kinase 0.0065 0.0378 0.0965
Brugia malayi Immunoglobulin I-set domain containing protein 0.0384 0.3584 0.3573
Loa Loa (eye worm) hypothetical protein 0.0095 0.0678 0.0663
Onchocerca volvulus 0.009 0.0631 0.178
Echinococcus multilocularis raf serine:threonine protein kinase 0.0046 0.0185 0.0184
Giardia lamblia Kinase, CMGC MAPK 0.0074 0.0465 0.0648
Trypanosoma cruzi STE/STE20 serine/threonine-protein kinase, putative 0.0075 0.0475 0.1392
Echinococcus multilocularis cyclin dependent kinase 1 0.0112 0.0854 0.0933
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.014 0.1128 0.1239
Plasmodium vivax unspecified product 0.0092 0.0647 0.4862
Loa Loa (eye worm) raf kinase 0.0038 0.0104 0.0088
Loa Loa (eye worm) hypothetical protein 0.0038 0.0104 0.0088
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0137 0.1098 0.2769
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0062 0.0345 0.0835
Echinococcus granulosus protein kinase c eta type 0.0038 0.0104 0.0217
Brugia malayi ribosomal protein S6 kinase alpha 3 0.011 0.0835 0.082
Echinococcus multilocularis Glutaredoxin protein 5 0.0137 0.1098 0.1206
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.007 0.0426 0.1142
Schistosoma mansoni tyrosine kinase 0.0043 0.0153 0.039
Loa Loa (eye worm) hypothetical protein 0.0191 0.1646 0.1633
Loa Loa (eye worm) AGC/PKC/IOTA protein kinase 0.0154 0.1269 0.1255
Schistosoma mansoni vav2 0.0042 0.015 0.0384
Toxoplasma gondii AGC kinase 0.0276 0.2502 1
Brugia malayi Serine/threonine-protein kinase Pim-3 0.0371 0.3452 0.3441
Brugia malayi Protein kinase c protein 2 0.0101 0.0735 0.072
Entamoeba histolytica protein kinase, putative 0.0076 0.049 0.1686
Loa Loa (eye worm) AGC/PKA protein kinase 0.0062 0.0345 0.033
Echinococcus granulosus mitogen activated protein kinase 0.0074 0.0465 0.1142
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0029 0.0021 0.0001
Schistosoma mansoni unc-13 (munc13) 0.0039 0.0118 0.0302
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.028 0.2537 1
Giardia lamblia Kinase, CMGC GSK 0.0123 0.0964 0.2901
Leishmania major cathepsin L-like protease 0.007 0.0426 0.1147
Echinococcus multilocularis mitogen activated protein kinase 11 0.0157 0.1302 0.1434
Echinococcus granulosus histone lysine methyltransferase setb 0.0033 0.0052 0.0083
Loa Loa (eye worm) hypothetical protein 0.0062 0.0345 0.033
Leishmania major cathepsin L-like protease 0.007 0.0426 0.1147
Echinococcus multilocularis mitogen activated protein kinase 14 0.0157 0.1302 0.1434
Loa Loa (eye worm) STE/STE20/KHS protein kinase 0.0029 0.0021 0.0004
Echinococcus granulosus MAP kinase activated protein kinase 2 0.0417 0.3914 1
Trichomonas vaginalis CMGC family protein kinase 0.0074 0.0465 0.1343
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0123 0.0964 0.3722
Brugia malayi MAP kinase sur-1 0.0074 0.0465 0.0449
Schistosoma mansoni protein kinase C 0.0039 0.0118 0.0302
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0062 0.0345 0.0364
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0038 0.0104 0.0094
Schistosoma mansoni serine/threonine protein kinase 0.014 0.1128 0.2881
Echinococcus multilocularis myosin iiia 0.0075 0.0475 0.0509
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0152 0.1256 0.3173
Schistosoma mansoni diacylglycerol kinase theta 0.0038 0.0104 0.0266
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.007 0.0426 0.1142
Echinococcus multilocularis enhancer of mRNA decapping protein 4 0.0044 0.0169 0.0167
Trichomonas vaginalis AGC family protein kinase 0.014 0.1128 0.4099
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0152 0.1256 0.1382
Echinococcus multilocularis protein kinase shaggy 0.0123 0.0964 0.1056
Giardia lamblia Kinase, CMGC CDK 0.0112 0.0854 0.2406
Echinococcus granulosus C2 calcium dependent membrane targeting 0.0039 0.0118 0.0253
Echinococcus multilocularis serine:threonine protein kinase 0.0107 0.0802 0.0875
Trypanosoma brucei protein kinase A catalytic subunit, putative 0.0062 0.0345 0.0807
Trichomonas vaginalis STE family protein kinase 0.0052 0.0249 0.0447
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.0142 0.1151 0.4356
Loa Loa (eye worm) camk/mapkapk/mapkapk protein kinase 0.0417 0.3914 0.3904
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0073 0.0458 0.1125
Entamoeba histolytica protein kinase, putative 0.0116 0.0892 0.3313
Entamoeba histolytica protein kinase, putative 0.0276 0.2502 0.9815
Echinococcus granulosus casein kinase I alpha 0.0059 0.0321 0.0773
Echinococcus multilocularis mitogen activated protein kinase 11 0.0157 0.1302 0.1434
Schistosoma mansoni tyrosine kinase 0.0065 0.0378 0.0965
Brugia malayi Protein kinase domain containing protein 0.0087 0.0602 0.0587
Echinococcus granulosus Rac GTPase activating protein 1 0.0038 0.0104 0.0217
Plasmodium falciparum cAMP-dependent protein kinase catalytic subunit 0.0062 0.0345 0.1723
Echinococcus multilocularis N chimaerin 0.0038 0.0104 0.0094
Brugia malayi Pre-SET motif family protein 0.0033 0.0052 0.0036
Onchocerca volvulus 0.034 0.3147 0.9112
Echinococcus multilocularis mitogen activated protein kinase 0.0074 0.0465 0.0497
Trypanosoma cruzi casein kinase, delta isoform, putative 0.0059 0.0321 0.075
Plasmodium vivax rac-beta serine/threonine protein kinase, putative 0.0154 0.1274 1
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0123 0.0964 0.0949
Echinococcus multilocularis rac serine:threonine kinase 0.0159 0.132 0.1455
Brugia malayi Protein kinase domain containing protein 0.014 0.1128 0.1113
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0112 0.0854 0.2143
Trypanosoma cruzi casein kinase, putative 0.0059 0.0321 0.075
Leishmania major cathepsin L-like protease 0.007 0.0426 0.1147
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.0122 0.0951 0.3365
Loa Loa (eye worm) hypothetical protein 0.0099 0.0716 0.0701
Brugia malayi serine/threonine protein kinase 6 0.0142 0.1151 0.1136
Schistosoma mansoni serine/threonine protein kinase 0.034 0.3147 0.8039
Echinococcus multilocularis aurora kinase A 0.0142 0.1151 0.1265
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0043 0.0152 0.0136
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0043 0.0152 0.0339
Echinococcus granulosus serine:threonine protein kinase MARK2 0.0175 0.1481 0.3753
Entamoeba histolytica protein kinase, putative 0.0044 0.0166 0.0377
Brugia malayi C1-like domain containing protein 0.0146 0.1188 0.1173
Echinococcus granulosus neural Wiskott Aldrich syndrome protein 0.0035 0.0073 0.0135
Giardia lamblia Kinase, CMGC GSK 0.0123 0.0964 0.2901
Onchocerca volvulus 0.0128 0.1011 0.2888
Trypanosoma cruzi casein kinase, delta isoform, putative 0.0042 0.0145 0.0013
Entamoeba histolytica protein kinase, putative 0.0057 0.0295 0.0898
Brugia malayi Protein kinase domain containing protein 0.0116 0.0892 0.0878
Trypanosoma brucei protein kinase, putative 0.0074 0.0465 0.1305
Schistosoma mansoni hypothetical protein 0.0035 0.0073 0.0185
Schistosoma mansoni serine/threonine protein kinase 0.0085 0.058 0.1481
Echinococcus multilocularis cyclin dependent kinase 5 0.0112 0.0854 0.0933
Schistosoma mansoni hypothetical protein 0.0038 0.0104 0.0266
Schistosoma mansoni serine/threonine-protein kinase 0.0159 0.132 0.3373
Schistosoma mansoni protein kinase 0.0059 0.0321 0.082
Loa Loa (eye worm) hypothetical protein 0.0128 0.1011 0.0997
Loa Loa (eye worm) hypothetical protein 0.0031 0.0034 0.0018
Trichomonas vaginalis CMGC family protein kinase 0.0112 0.0854 0.2963
Trichomonas vaginalis AGC family protein kinase 0.014 0.1128 0.4099
Loa Loa (eye worm) AGC/DMPK/ROCK protein kinase 0.1022 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.007 0.0426 0.1142
Trichomonas vaginalis AGC family protein kinase 0.0281 0.2547 1
Schistosoma mansoni cell adhesion molecule 0.0031 0.0034 0.0087
Echinococcus multilocularis PAK box P21 Rho binding 0.0035 0.0073 0.0059
Loa Loa (eye worm) hypothetical protein 0.009 0.0631 0.0616
Echinococcus granulosus epidermal growth factor receptor 0.0073 0.0458 0.1125
Entamoeba histolytica protein kinase, putative 0.0057 0.0295 0.0898
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.0371 0.3452 1
Brugia malayi p21/Cdc42/Rac1-activated kinase 0.0041 0.0141 0.0125
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0062 0.0345 0.0835
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.007 0.0426 0.1142
Brugia malayi protein kinase C II. 0.0179 0.1522 0.1508
Brugia malayi Immunoglobulin I-set domain containing protein 0.0129 0.1025 0.1011
Echinococcus multilocularis serine:threonine protein kinase MARK2 0.0175 0.1481 0.1635
Loa Loa (eye worm) hypothetical protein 0.0038 0.0104 0.0088
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0371 0.3452 0.3441
Loa Loa (eye worm) hypothetical protein 0.0033 0.0052 0.0036
Schistosoma mansoni serine/threonine protein kinase 0.0085 0.058 0.1481
Trichomonas vaginalis AGC family protein kinase 0.0281 0.2547 1
Echinococcus granulosus casein kinase I delta 0.0059 0.0321 0.0773
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0062 0.0345 0.0851
Trichomonas vaginalis CMGC family protein kinase 0.0092 0.0647 0.21
Echinococcus multilocularis casein kinase I alpha 0.0059 0.0321 0.0337
Echinococcus multilocularis cyclin dependent kinase 0.0112 0.0854 0.0933
Loa Loa (eye worm) AUR protein kinase 0.0142 0.1151 0.1136
Loa Loa (eye worm) hypothetical protein 0.0043 0.0152 0.0136
Echinococcus granulosus enhancer of mRNA decapping protein 4 0.0044 0.0169 0.0382
Brugia malayi Protein kinase domain 0.0076 0.049 0.0474
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0062 0.0345 0.0364
Trypanosoma cruzi casein kinase, putative 0.0059 0.0321 0.075
Schistosoma mansoni serine/threonine protein kinase 0.014 0.1128 0.2881
Schistosoma mansoni hypothetical protein 0.0068 0.0403 0.103
Trichomonas vaginalis STE family protein kinase 0.0076 0.049 0.1448
Schistosoma mansoni diacylglycerol kinase theta 0.0038 0.0104 0.0266
Loa Loa (eye worm) CAMK/CAMKL/CHK1 protein kinase 0.0203 0.1765 0.1752
Trichomonas vaginalis CMGC family protein kinase 0.0092 0.0647 0.21
Schistosoma mansoni hypothetical protein 0.0035 0.0073 0.0185
Brugia malayi Temporarily assigned gene name protein 59 0.0142 0.1157 0.1143
Brugia malayi Kinase associated domain 1 family protein 0.0068 0.0403 0.0388
Echinococcus granulosus 3'partial|serine:threonine protein kinase PAK 2 0.0035 0.0073 0.0135
Trichomonas vaginalis AGC family protein kinase 0.0142 0.1151 0.4195
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0029 0.0021 0.0002
Loa Loa (eye worm) hypothetical protein 0.0133 0.1057 0.1042
Echinococcus granulosus casein kinase ii subunit alpha 0.0092 0.0647 0.1609
Trichomonas vaginalis CMGC family protein kinase 0.0092 0.0647 0.21
Toxoplasma gondii casein kinase I 0.0059 0.0321 0.1097
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0043 0.0152 0.0136
Echinococcus granulosus calcium activated potassium channel 0.0085 0.058 0.1437
Brugia malayi Cam kinase protein 1 0.0043 0.0152 0.0136
Plasmodium vivax protein kinase Crk2 0.0112 0.0854 0.6562
Brugia malayi Pre-SET motif family protein 0.0228 0.2013 0.2
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.028 0.2537 0.2525
Entamoeba histolytica serine/threonine protein kinase, putative 0.028 0.2537 0.9959
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0137 0.1098 0.1206
Brugia malayi Protein kinase domain containing protein 0.0112 0.0854 0.0839
Leishmania major protein kinase, putative 0.0142 0.1151 0.4187
Trichomonas vaginalis CAMK family protein kinase 0.028 0.2537 0.9957
Brugia malayi Furin-like cysteine rich region family protein 0.0073 0.0458 0.0443
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.007 0.0426 0.1142
Schistosoma mansoni protein kinase 0.0076 0.049 0.1252
Trichomonas vaginalis AGC family protein kinase 0.0281 0.2547 1
Echinococcus granulosus protein kinase c epsilon type 0.0179 0.1522 0.3857
Echinococcus multilocularis myotubularin protein 13 0.0042 0.015 0.0146
Loa Loa (eye worm) STE/STE20/PAKA protein kinase 0.0041 0.0141 0.0125
Trypanosoma brucei protein kinase, putative 0.0123 0.0964 0.339
Plasmodium vivax NIMA-related protein kinase (Pfnek-1), putative 0.0132 0.1047 0.8138
Loa Loa (eye worm) STE/STE20/PAKA protein kinase 0.0041 0.0141 0.0125
Trichomonas vaginalis CMGC family protein kinase 0.0112 0.0854 0.2963
Giardia lamblia Kinase, AGC PKA 0.0062 0.0345 0.0109
Echinococcus granulosus dual specificity 0.0116 0.0892 0.2241
Loa Loa (eye worm) hypothetical protein 0.0068 0.0403 0.0388
Schistosoma mansoni protein kinase C mu 0.0038 0.0104 0.0266
Loa Loa (eye worm) hypothetical protein 0.0099 0.0716 0.0701
Brugia malayi Protein kinase domain containing protein 0.0085 0.058 0.0564
Plasmodium falciparum NIMA related kinase 1 0.0132 0.1047 0.7973
Toxoplasma gondii diacylglycerol kinase, putative 0.0038 0.0104 0.0212
Loa Loa (eye worm) hypothetical protein 0.0038 0.0104 0.0088
Brugia malayi STE20-like kinase MST 0.0265 0.2388 0.2375
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0074 0.0465 0.1349
Entamoeba histolytica hypothetical protein 0.0038 0.0104 0.0128
Leishmania major protein kinase A catalytic subunit isoform 1 0.0062 0.0345 0.0811
Trichomonas vaginalis AGC family protein kinase 0.0144 0.1173 0.4289
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0043 0.0152 0.0815
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0038 0.0104 0.0266
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0074 0.0465 0.1311
Onchocerca volvulus 0.0059 0.0321 0.0877
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.007 0.0426 0.1142
Echinococcus granulosus epidermal growth factor receptor 0.0073 0.0458 0.1125
Entamoeba histolytica diacylglycerol kinase, putative 0.0038 0.0104 0.0128
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0157 0.1302 0.4845
Plasmodium falciparum casein kinase 2, alpha subunit 0.0092 0.0647 0.4407
Entamoeba histolytica serine/threonine-protein kinase 3, putative 0.0075 0.0475 0.1626
Entamoeba histolytica protein kinase, putative 0.0281 0.2547 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.0154 0.0138
Echinococcus granulosus mitogen activated protein kinase 3 0.0074 0.0465 0.1142
Onchocerca volvulus 0.0033 0.0052 0.0094
Echinococcus granulosus c-Jun N-terminal kinases 0.0273 0.247 0.6293
Trichomonas vaginalis CMGC family protein kinase 0.0112 0.0854 0.2963
Loa Loa (eye worm) hypothetical protein 0.0079 0.0522 0.0506
Trichomonas vaginalis CK1 family protein kinase 0.0059 0.0321 0.0746
Echinococcus multilocularis serine:threonine protein kinase 0.0107 0.0802 0.0875
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0038 0.0104 0.0217
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0197 0.1708 0.1889
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.014 0.1128 0.2844
Plasmodium falciparum protein kinase 5 0.0112 0.0854 0.6257
Trypanosoma cruzi cdc2-related kinase 1 0.0112 0.0854 0.2975
Schistosoma mansoni rac gtpase activating protein 0.0038 0.0104 0.0266
Schistosoma mansoni serine/threonine protein kinase 0.0074 0.0465 0.1187
Trypanosoma cruzi cysteine peptidase, putative 0.007 0.0426 0.1186
Echinococcus multilocularis C2 calcium dependent membrane targeting 0.0039 0.0118 0.011
Brugia malayi P21-Rho-binding domain containing protein 0.0035 0.0073 0.0056
Trichomonas vaginalis CK1 family protein kinase 0.0059 0.0321 0.0746
Brugia malayi Immunoglobulin I-set domain containing protein 0.0029 0.002 0.0004
Trichomonas vaginalis CMGC family protein kinase 0.0092 0.0647 0.21
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0037 0.0096 0.008
Schistosoma mansoni serine/threonine protein kinase 0.0203 0.1765 0.4509
Schistosoma mansoni protein kinase 0.0092 0.0647 0.1652
Brugia malayi serine/threonine-protein kinase plk-2 0.028 0.2537 0.2525
Echinococcus granulosus serine threonine protein kinase nrc 0.0154 0.1274 0.3222
Echinococcus granulosus neuroglian 0.0035 0.0077 0.0148
Brugia malayi map kinase activated protein kinase protein 2 0.0417 0.3914 0.3904
Brugia malayi serine/threonine kinase 12 0.0142 0.1151 0.1136
Brugia malayi Protein kinase domain containing protein 0.0152 0.1256 0.1241
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0038 0.0104 0.0088
Echinococcus granulosus N chimaerin 0.0038 0.0104 0.0217
Trichomonas vaginalis CMGC family protein kinase 0.0074 0.0465 0.1343
Loa Loa (eye worm) hypothetical protein 0.0044 0.0165 0.0149
Trichomonas vaginalis CMGC family protein kinase 0.0074 0.0465 0.1343
Schistosoma mansoni serine/threonine protein kinase 0.0029 0.002 0.0051
Leishmania major casein kinase, putative 0.0059 0.0321 0.0709
Echinococcus multilocularis serine threonine protein kinase 0.0185 0.1582 0.1747
Onchocerca volvulus Serine\/threonine kinase homolog 0.028 0.2537 0.7336
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.014 0.1128 0.1113
Brugia malayi protein kinase C3,putative 0.0147 0.1202 0.1188
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.0076 0.049 0.0526
Echinococcus multilocularis serine:threonine protein kinase PAK 4 0.0203 0.1764 0.1951
Schistosoma mansoni serine/threonine protein kinase 0.0175 0.1481 0.3785
Loa Loa (eye worm) P21-Rho-binding domain-containing protein 0.0035 0.0073 0.0056
Giardia lamblia Kinase, CMGC CDK 0.0112 0.0854 0.2406
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 2 0.0062 0.0345 0.0807
Brugia malayi P21-Rho-binding domain containing protein 0.0035 0.0073 0.0056
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.007 0.0426 0.1142
Trichomonas vaginalis CAMK family protein kinase 0.0121 0.0938 0.3313
Echinococcus multilocularis serine:threonine protein kinase 38 0.014 0.1128 0.1239
Loa Loa (eye worm) TK protein kinase 0.0129 0.1025 0.1011
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 0.0157 0.1302 0.4823
Echinococcus multilocularis serine:threonine protein kinase MARK2 0.0175 0.1481 0.1635
Trypanosoma cruzi polo-like protein kinase, putative 0.028 0.2537 1
Trichomonas vaginalis AGC family protein kinase 0.0281 0.2547 1
Loa Loa (eye worm) hypothetical protein 0.0131 0.1046 0.1031
Echinococcus multilocularis neural Wiskott Aldrich syndrome protein 0.0035 0.0073 0.0059
Toxoplasma gondii AGC kinase 0.0062 0.0345 0.1196
Giardia lamblia Kinase, AGC AKT 0.011 0.0835 0.2319
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0043 0.0152 0.0148
Echinococcus granulosus casein kinase I delta 0.0059 0.0321 0.0773
Loa Loa (eye worm) AUR protein kinase 0.0142 0.1151 0.1136
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0033 0.0052 0.0036
Echinococcus multilocularis casein kinase I delta 0.0059 0.0321 0.0337
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0052 0.0134
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0038 0.0104 0.0088
Schistosoma mansoni protein kinase 0.0076 0.049 0.1252
Loa Loa (eye worm) RasGEF domain-containing protein 0.0038 0.0104 0.0088
Schistosoma mansoni protein kinase 0.0197 0.1708 0.4365
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0043 0.0152 0.0339
Loa Loa (eye worm) hypothetical protein 0.009 0.0631 0.0616
Schistosoma mansoni serine/threonine protein kinase 0.0121 0.0939 0.24
Echinococcus multilocularis Rac GTPase activating protein 1 0.0038 0.0104 0.0094
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0043 0.0152 0.0339
Trichomonas vaginalis CAMK family protein kinase 0.028 0.2537 0.9957
Trichomonas vaginalis CMGC family protein kinase 0.0123 0.0964 0.3418
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0232 0.2062 0.2049
Leishmania major casein kinase II, putative 0.0092 0.0647 0.2074
Plasmodium falciparum serine/threonine protein kinase, putative 0.0142 0.1151 0.8897
Toxoplasma gondii AGC kinase 0.0062 0.0345 0.1196
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0052 0.0134
Schistosoma mansoni tyrosine kinase 0.0073 0.0458 0.117
Echinococcus multilocularis nervana 2 0.0137 0.1098 0.1206
Schistosoma mansoni protein kinase 0.0043 0.0152 0.0388
Schistosoma mansoni serine/threonine protein kinase 0.0041 0.0141 0.0361
Onchocerca volvulus 0.0345 0.3193 0.9248
Schistosoma mansoni serine/threonine protein kinase 0.0085 0.058 0.1481
Echinococcus granulosus aurora kinase A 0.0142 0.1151 0.2904
Plasmodium vivax cAMP-dependent protein kinase catalytic subunit, putative 0.0062 0.0345 0.2397
Schistosoma mansoni serine/threonine protein kinase 0.0112 0.0854 0.2182
Schistosoma mansoni ste20-related kinase 0.0208 0.1813 0.4633
Schistosoma mansoni serine/threonine protein kinase 0.0043 0.0153 0.039
Trichomonas vaginalis AGC family protein kinase 0.0142 0.1151 0.4195
Plasmodium falciparum RAC-beta serine/threonine protein kinase 0.0154 0.1274 1
Schistosoma mansoni serine/threonine protein kinase 0.0371 0.3452 0.8818
Echinococcus multilocularis casein kinase I alpha 0.0059 0.0321 0.0337
Trypanosoma cruzi cdc2-related kinase 3 0.0112 0.0854 0.2975
Entamoeba histolytica serine/threonine protein kinase STE20, putative 0.0075 0.0475 0.1626
Entamoeba histolytica protein kinase, putative 0.014 0.1128 0.4263
Giardia lamblia Kinase, CMGC CK2 0.0092 0.0647 0.1469
Loa Loa (eye worm) hypothetical protein 0.0038 0.0104 0.0088
Echinococcus multilocularis nervana 2 0.0137 0.1098 0.1206
Onchocerca volvulus Tyrosine kinase homolog 0.0365 0.3393 0.983
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0074 0.0465 0.1311
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0043 0.0152 0.0815
Echinococcus multilocularis casein kinase ii subunit alpha 0.0092 0.0647 0.0701
Schistosoma mansoni tyrosine kinase 0.0073 0.0458 0.117
Echinococcus granulosus Protein kinase C brain isozyme 0.0223 0.1962 0.4988
Brugia malayi cell division control protein 2 homolog 0.0112 0.0854 0.0839
Trichomonas vaginalis CAMK family protein kinase 0.0043 0.0152 0.0043
Brugia malayi RhoGAP domain containing protein 0.0038 0.0104 0.0088
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0384 0.3584 0.3573
Echinococcus multilocularis casein kinase i 0.0059 0.0321 0.0337
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0146 0.1188 0.1173
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0157 0.1302 0.4845
Entamoeba histolytica casein kinase, putative 0.0092 0.0647 0.2319
Entamoeba histolytica PH domain containing protein kinase, putative 0.0159 0.132 0.5042
Giardia lamblia Aurora kinase 0.0142 0.1151 0.3744
Leishmania major rac serine-threonine kinase, putative,protein kinase, putative 0.0115 0.0881 0.3056
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.007 0.0426 0.1142
Toxoplasma gondii aurora kinase 0.0142 0.1151 0.4485
Schistosoma mansoni serine/threonine protein kinase 0.0273 0.247 0.6312
Schistosoma mansoni protein kinase 0.0043 0.0152 0.0388
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0232 0.2062 0.5244
Loa Loa (eye worm) AGC/PKN protein kinase 0.014 0.1128 0.1113
Echinococcus granulosus Serine:threonine protein kinase PLK4 0.0141 0.1143 0.2885
Plasmodium vivax calcium-dependent protein kinase, putative 0.0043 0.0152 0.0815
Brugia malayi Protein kinase domain containing protein 0.0187 0.1602 0.1589
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0116 0.0892 0.3135
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.0076 0.049 0.1207
Echinococcus multilocularis protein kinase c epsilon type 0.0179 0.1522 0.168
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase 0.0063 0.0355 0.0339
Trichomonas vaginalis AGC family protein kinase 0.014 0.1128 0.4099
Schistosoma mansoni protein kinase 0.0029 0.0021 0.0053
Echinococcus multilocularis epidermal growth factor receptor 0.0073 0.0458 0.049
Trichomonas vaginalis AGC family protein kinase 0.0062 0.0345 0.0847
Brugia malayi Variant SH3 domain containing protein 0.0038 0.0104 0.0088
Echinococcus multilocularis dual specificity 0.0116 0.0892 0.0976
Echinococcus multilocularis insulin receptor 0.0152 0.1256 0.1382
Onchocerca volvulus 0.0039 0.0118 0.0287
Echinococcus multilocularis telomerase reverse transcriptase subunit 0.0044 0.0165 0.0162
Loa Loa (eye worm) CAMK/CAMKL/MARK protein kinase 0.0107 0.0802 0.0787
Echinococcus granulosus serine:threonine protein kinase 0.0107 0.0802 0.2009
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0074 0.0465 0.1683
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0112 0.0854 0.0839
Plasmodium falciparum glycogen synthase kinase 3 0.0123 0.0964 0.7233
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0112 0.0854 0.0839
Loa Loa (eye worm) AGC/PKA protein kinase 0.0062 0.0345 0.033
Entamoeba histolytica cell division protein kinase 2, putative 0.0112 0.0854 0.3159
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0108 0.0807 0.0792
Entamoeba histolytica protein kinase , putative 0.0142 0.1151 0.4356
Schistosoma mansoni tyrosine kinase 0.0073 0.0458 0.117
Toxoplasma gondii NIMA-related protein kinase NIMA1 0.0132 0.1047 0.4061
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0142 0.1151 0.2904
Entamoeba histolytica diacylglycerol kinase, putative 0.0038 0.0104 0.0128
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0276 0.2502 0.2489
Echinococcus granulosus casein kinase I alpha 0.0059 0.0321 0.0773
Loa Loa (eye worm) TK/INSR protein kinase 0.0152 0.1256 0.1241
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0043 0.0152 0.0407
Leishmania major protein kinase, putative 0.0075 0.0475 0.1354
Echinococcus granulosus insulin receptor 0.0152 0.1256 0.3173
Echinococcus multilocularis Diacylglycerol kinase theta 0.0038 0.0104 0.0094
Schistosoma mansoni tyrosine kinase 0.0117 0.0906 0.2314
Entamoeba histolytica hypothetical protein 0.0116 0.0892 0.3313
Echinococcus multilocularis death associated protein kinase 1 0.0918 0.896 1
Onchocerca volvulus 0.0123 0.0964 0.2751
Echinococcus granulosus serine:threonine protein kinase PLK1 0.028 0.2537 0.6464
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 2 0.0062 0.0345 0.0851
Schistosoma mansoni hypothetical protein 0.0035 0.0073 0.0185
Echinococcus granulosus roundabout 2 0.0043 0.0154 0.0343
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0117 0.0906 0.0991
Schistosoma mansoni serine/threonine protein kinase 0.0041 0.0141 0.0361
Echinococcus multilocularis MAP kinase activated protein kinase 2 0.0417 0.3914 0.4356
Brugia malayi Casein kinase II, alpha chain 0.0092 0.0647 0.0631
Trichomonas vaginalis STE family protein kinase 0.0076 0.049 0.1448
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0074 0.0465 0.0449
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0062 0.0345 0.0364
Echinococcus multilocularis casein kinase I alpha 0.0059 0.0321 0.0337
Schistosoma mansoni protein kinase 0.0142 0.1151 0.294
Brugia malayi Protein kinase domain containing protein 0.0281 0.2547 0.2535
Loa Loa (eye worm) hypothetical protein 0.0059 0.0313 0.0298
Echinococcus granulosus fibroblast growth factor receptor 4 0.0117 0.0906 0.2275
Brugia malayi p70 ribosomal S6 kinase beta 0.0276 0.2502 0.2489
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0043 0.0152 0.0136
Schistosoma mansoni protein kinase C mu 0.0146 0.1188 0.3034
Onchocerca volvulus 0.0259 0.2329 0.6728
Giardia lamblia Kinase, AGC PKA 0.0154 0.1274 0.4302
Trichomonas vaginalis AGC family protein kinase 0.0142 0.1151 0.4195
Echinococcus granulosus mitogen activated protein kinase 11 0.0157 0.1302 0.3293
Trichomonas vaginalis CMGC family protein kinase 0.0092 0.0647 0.21
Schistosoma mansoni serine/threonine protein kinase 0.0232 0.2062 0.5268
Brugia malayi Hr1 repeat family protein 0.014 0.1128 0.1113
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0117 0.0906 0.2275
Trichomonas vaginalis CAMK family protein kinase 0.028 0.2537 0.9957
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0116 0.0892 0.3091
Schistosoma mansoni unc-13 (munc13) 0.0039 0.0118 0.0302
Loa Loa (eye worm) TK/EGFR protein kinase 0.0073 0.0458 0.0443
Trichomonas vaginalis CAMK family protein kinase 0.028 0.2537 0.9957
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0123 0.0964 0.3404
Schistosoma mansoni nephrin 0.0035 0.0077 0.0198
Echinococcus multilocularis Serine:threonine protein kinase PLK4 0.0141 0.1143 0.1257
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0116 0.0892 0.0878
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0043 0.0152 0.0148
Loa Loa (eye worm) hypothetical protein 0.0153 0.1266 0.1252
Loa Loa (eye worm) Ras association domain family 1 isoform A 0.0038 0.0104 0.0088
Trichomonas vaginalis conserved hypothetical protein 0.0059 0.0313 0.0715
Echinococcus multilocularis rho associated protein kinase 0.034 0.3147 0.3497
Loa Loa (eye worm) CMGC/CK2 protein kinase 0.0092 0.0647 0.0631
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0228 0.2013 0.2
Schistosoma mansoni serine/threonine protein kinase 0.0223 0.1962 0.5014
Schistosoma mansoni protein kinase 0.0043 0.0152 0.0388
Brugia malayi Protein kinase domain containing protein 0.014 0.1128 0.1113
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0029 0.0021 0.0002
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.0121 0.0939 0.1029
Onchocerca volvulus 0.0133 0.1057 0.3022
Schistosoma mansoni serine/threonine protein kinase 0.0029 0.002 0.0051
Entamoeba histolytica protein kinase 2, putative 0.0154 0.1274 0.4857
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0043 0.0152 0.0407
Brugia malayi casein kinase I 0.0059 0.0321 0.0305
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0043 0.0152 0.0407
Onchocerca volvulus 0.0323 0.297 0.8598
Echinococcus granulosus Diacylglycerol kinase theta 0.0038 0.0104 0.0217
Brugia malayi Stress-activated protein kinase jnk-1 0.0273 0.247 0.2458
Leishmania major protein kinase A catalytic subunit 0.0062 0.0345 0.0811
Loa Loa (eye worm) hypothetical protein 0.0153 0.1266 0.1252
Trichomonas vaginalis CAMK family protein kinase 0.028 0.2537 0.9957
Echinococcus granulosus serine/threonine protein kinase 0.0159 0.132 0.3339
Plasmodium falciparum casein kinase 1 0.0059 0.0321 0.1507
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0038 0.0104 0.0266
Trichomonas vaginalis CAMK family protein kinase 0.028 0.2537 0.9957
Trichomonas vaginalis CAMK family protein kinase 0.0121 0.0938 0.3313
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0074 0.0465 0.1305
Entamoeba histolytica casein kinase 1, putative 0.0059 0.0321 0.1004
Echinococcus granulosus myotubularin protein 13 0.0042 0.015 0.0334
Trypanosoma brucei Casein kinase II 0.0092 0.0647 0.2065
Trypanosoma brucei polo-like protein kinase 0.028 0.2537 0.9957
Echinococcus multilocularis serine:threonine protein kinase N2 0.014 0.1128 0.1239
Trypanosoma brucei STE20-like serine/threonine-protein kinase 1, putative 0.0075 0.0475 0.1348
Loa Loa (eye worm) CAMK protein kinase 0.0029 0.002 0.0004
Brugia malayi diacylglycerol kinase 0.0038 0.0104 0.0088
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.007 0.0426 0.1142
Trypanosoma brucei mitogen-activated protein kinase 3, putative 0.0157 0.1302 0.4802
Echinococcus multilocularis mitogen activated protein kinase 14 0.0157 0.1302 0.1434
Brugia malayi intracellular kinase 0.0123 0.0964 0.0949
Echinococcus granulosus cyclin dependent kinase 5 0.0112 0.0854 0.2143
Schistosoma mansoni serine/threonine protein kinase 0.0062 0.0345 0.0882
Plasmodium vivax glycogen synthase kinase 3, putative 0.0123 0.0964 0.7459
Echinococcus granulosus NDR protein kinase 0.014 0.1128 0.2844
Schistosoma mansoni serine/threonine protein kinase 0.014 0.1128 0.2881
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0074 0.0465 0.1349
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0029 0.002 0.0004
Giardia lamblia Kinase, NEK 0.0132 0.1047 0.3275
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0031 0.0034 0.0037
Giardia lamblia Kinase, STE STE20 0.0075 0.0475 0.0694
Echinococcus granulosus casein kinase I alpha 0.0059 0.0321 0.0773
Loa Loa (eye worm) CMGC/MAPK/JNK protein kinase 0.0273 0.247 0.2458
Onchocerca volvulus 0.0042 0.0145 0.0363
Schistosoma mansoni serine/threonine protein kinase 0.0121 0.0939 0.24
Schistosoma mansoni serine/threonine kinase 0.014 0.1128 0.2881
Trichomonas vaginalis AGC family protein kinase 0.0281 0.2547 1
Echinococcus granulosus twitchin 0.0053 0.0254 0.0601
Trypanosoma brucei aurora B kinase 0.0142 0.1151 0.4169
Giardia lamblia Kinase, STE STE20 0.0076 0.049 0.0762
Schistosoma mansoni tyrosine kinase 0.0152 0.1256 0.3208
Loa Loa (eye worm) CK1/CK1/CK1-D protein kinase 0.0059 0.0321 0.0305
Onchocerca volvulus 0.0153 0.1266 0.3631
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0062 0.0345 0.0364
Schistosoma mansoni kinase 0.03 0.2742 0.7006
Entamoeba histolytica protein kinase domain containing protein 0.0142 0.1151 0.4356
Echinococcus granulosus unc 13 munc13 0.0039 0.0118 0.0253
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0064 0.0365 0.0932
Trypanosoma cruzi cruzipain precursor, putative 0.007 0.0426 0.1186
Loa Loa (eye worm) AGC/NDR protein kinase 0.014 0.1128 0.1113
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.014 0.1128 0.1239
Trichomonas vaginalis AGC family protein kinase 0.0281 0.2547 1
Entamoeba histolytica protein kinase, putative 0.0281 0.2547 1
Schistosoma mansoni serine/threonine protein kinase 0.0059 0.0321 0.082
Echinococcus granulosus serine:threonine protein kinase PAK 4 0.0203 0.1764 0.448
Echinococcus granulosus cyclin dependent kinase 1 0.0112 0.0854 0.2143
Echinococcus multilocularis c Jun NH2 terminal kinase 0.0273 0.247 0.2741
Entamoeba histolytica protein kinase, putative 0.0116 0.0892 0.3313
Echinococcus multilocularis RNA directed DNA polymerase 0.0044 0.0165 0.0162
Loa Loa (eye worm) STE/STE20/MST protein kinase 0.0265 0.2388 0.2375
Trichomonas vaginalis CK1 family protein kinase 0.0059 0.0321 0.0746
Schistosoma mansoni serine/threonine protein kinase 0.0175 0.1481 0.3785
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0142 0.1151 0.8987
Echinococcus multilocularis protein kinase c eta type 0.0038 0.0104 0.0094
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.007 0.0426 0.1142
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0043 0.0152 0.0148
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.0371 0.3452 0.3838
Trypanosoma cruzi cdc2-related kinase 1 0.0112 0.0854 0.2975
Schistosoma mansoni serine/threonine protein kinase 0.0062 0.0345 0.0882
Entamoeba histolytica protein kinase, putative 0.0142 0.1151 0.4356
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0112 0.0854 0.3274
Trypanosoma cruzi cysteine peptidase, putative 0.007 0.0426 0.1186
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0336 0.3099 0.3088
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0031 0.004 0.0052
Loa Loa (eye worm) hypothetical protein 0.0042 0.015 0.0134
Loa Loa (eye worm) AUR protein kinase 0.0142 0.1151 0.1136
Brugia malayi serine/threonine-protein kinase PAK 7 0.0237 0.2113 0.21
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 0.0157 0.1302 0.1288
Entamoeba histolytica protein kinase, putative 0.0043 0.0152 0.0321
Echinococcus granulosus protein kinase shaggy 0.0123 0.0964 0.2424
Entamoeba histolytica PH domain containing protein kinase, putative 0.0159 0.132 0.5042
Echinococcus granulosus nervana 2 0.0137 0.1098 0.2769
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0223 0.1962 0.2173
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0154 0.1274 0.4729
Brugia malayi RhoGAP domain containing protein 0.0038 0.0104 0.0088
Echinococcus granulosus serine:threonine protein kinase 0.0107 0.0802 0.2009
Trichomonas vaginalis CMGC family protein kinase 0.0092 0.0647 0.21
Trypanosoma cruzi major cysteine proteinase, putative 0.0055 0.0275 0.0559
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.0142 0.1151 0.4356
Brugia malayi WH1 domain containing protein 0.0035 0.0073 0.0056
Toxoplasma gondii protein kinase, cAMP-dependent, catalytic chain 0.0062 0.0345 0.1196
Entamoeba histolytica protein kinase, putative 0.0052 0.0249 0.0713
Echinococcus multilocularis roundabout 2 0.0043 0.0154 0.015
Trypanosoma cruzi cysteine peptidase, putative 0.007 0.0426 0.1186
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.007 0.0426 0.1142
Trypanosoma cruzi Protein kinase B 0.0159 0.132 0.4921
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.0076 0.049 0.1207
Echinococcus multilocularis unc 13 (munc13) 0.0039 0.0118 0.011
Brugia malayi Protein kinase domain containing protein 0.0107 0.0802 0.0787
Brugia malayi Pleckstrin Homology Domain 0.0042 0.015 0.0134
Trypanosoma cruzi STE/STE20 serine/threonine-protein kinase, putative 0.0075 0.0475 0.1392
Brugia malayi Protein kinase domain containing protein 0.0203 0.1765 0.1752
Echinococcus multilocularis calcium activated potassium channel 0.0085 0.058 0.0626
Brugia malayi RhoGEF domain containing protein 0.0038 0.0104 0.0088
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0112 0.0854 0.2945
Echinococcus multilocularis PAK box P21 Rho binding 0.0052 0.0249 0.0256
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0043 0.0152 0.0339
Trichomonas vaginalis CMGC family protein kinase 0.0123 0.0964 0.3418
Brugia malayi diacylglycerol kinase 0.0038 0.0104 0.0088

Activities

Activity type Activity value Assay description Source Reference
ED50 (functional) = 96.3 ug ml-1 Antiproliferative activity against human HT1080 cells after 4 days by MTT assay ChEMBL. 11374950

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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