Detailed information for compound 1029843

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 354.628 | Formula: C11H17BrClN3O3
  • H donors: 3 H acceptors: 5 LogP: 2.53 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: OCCC1CCN(CC1)c1nc(O)nc(c1Br)O.Cl
  • InChi: 1S/C11H16BrN3O3.ClH/c12-8-9(13-11(18)14-10(8)17)15-4-1-7(2-5-15)3-6-16;/h7,16H,1-6H2,(H2,13,14,17,18);1H
  • InChiKey: UMZLGOBBRXUGIC-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens thymidine phosphorylase Starlite/ChEMBL References
Escherichia coli thymidine phosphorylase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Mycobacterium tuberculosis Probable thymidine phosphorylase DeoA (tdrpase) (pyrimidine phosphorylase) Get druggable targets OG5_131632 All targets in OG5_131632
Mycobacterium ulcerans thymidine phosphorylase Get druggable targets OG5_131632 All targets in OG5_131632
Echinococcus granulosus thymidine phosphorylase Get druggable targets OG5_131632 All targets in OG5_131632
Echinococcus multilocularis thymidine phosphorylase Get druggable targets OG5_131632 All targets in OG5_131632
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi RNA recognition motif domain containing protein 0.0061 0.0275 0.0341
Leishmania major 3-hydroxy-3-methylglutaryl-CoA reductase 0.0136 0.0772 0.926
Loa Loa (eye worm) hypothetical protein 0.0035 0.0104 0.0145
Schistosoma mansoni hypothetical protein 0.0098 0.0517 0.0584
Schistosoma mansoni cpg binding protein 0.0067 0.0312 0.0353
Loa Loa (eye worm) hypothetical protein 0.0053 0.022 0.0307
Loa Loa (eye worm) hypothetical protein 0.0055 0.0237 0.0332
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0104 0.01
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0083 0.0422 0.0321
Loa Loa (eye worm) hypothetical protein 0.0055 0.0237 0.0332
Trypanosoma cruzi ubiquitin-conjugating enzyme E2, putative 0.0037 0.0118 0.1069
Mycobacterium tuberculosis Probable dehydrogenase 0.0083 0.0422 0.0321
Loa Loa (eye worm) hypothetical protein 0.0167 0.0972 0.1359
Onchocerca volvulus 0.0113 0.0616 0.1936
Leishmania major hypothetical protein, conserved 0.0035 0.0104 0.0895
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0055 0.0237 0.0237
Echinococcus granulosus histone acetyltransferase KAT2B 0.0142 0.0808 0.0808
Mycobacterium ulcerans hydrolase/amidase 0.0577 0.3685 0.3632
Schistosoma mansoni transcription factor LCR-F1 0.0185 0.1092 0.1234
Loa Loa (eye worm) hypothetical protein 0.0118 0.0648 0.0906
Loa Loa (eye worm) intermediate filament protein 0.0053 0.0219 0.0306
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0145 0.0831 0.1122
Brugia malayi Calcitonin receptor-like protein seb-1 0.0309 0.1914 0.2643
Echinococcus multilocularis dnaJ subfamily B 0.0412 0.2594 0.2594
Brugia malayi Nuclear hormone receptor-like 1 0.0062 0.0281 0.035
Loa Loa (eye worm) hypothetical protein 0.0113 0.0616 0.0862
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0056 0.0241 0.0273
Mycobacterium ulcerans aldehyde dehydrogenase 0.012 0.0664 0.0585
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0104 0.0145
Brugia malayi ecdysone receptor 0.0055 0.0237 0.0288
Echinococcus multilocularis peregrin 0.0039 0.0128 0.0128
Loa Loa (eye worm) hypothetical protein 0.0055 0.0237 0.0332
Onchocerca volvulus 0.0118 0.0648 0.2053
Loa Loa (eye worm) hypothetical protein 0.0025 0.0038 0.0053
Leishmania major trypanothione reductase 0.0037 0.0112 0.0997
Mycobacterium ulcerans aldehyde dehydrogenase 0.012 0.0664 0.0585
Loa Loa (eye worm) CXXC zinc finger family protein 0.0061 0.0275 0.0385
Brugia malayi ubiquitin conjugating enzyme protein 13 0.0037 0.0118 0.012
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0055 0.0237 0.0288
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0473 0.0534
Brugia malayi Intermediate filament tail domain containing protein 0.0053 0.0219 0.0262
Schistosoma mansoni thyroid hormone receptor 0.0503 0.32 0.3617
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0098 0.0517 0.0517
Loa Loa (eye worm) PHD-finger family protein 0.0022 0.0017 0.0023
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0145 0.0831 0.094
Echinococcus granulosus dnaJ subfamily B 0.0412 0.2594 0.2594
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0062 0.0281 0.0393
Loa Loa (eye worm) hypothetical protein 0.0055 0.0237 0.0332
Echinococcus granulosus geminin 0.0356 0.2222 0.2222
Mycobacterium tuberculosis Probable oxidoreductase 0.0093 0.0483 0.0383
Loa Loa (eye worm) hypothetical protein 0.0446 0.2819 0.3941
Schistosoma mansoni hypothetical protein 0.0098 0.0517 0.0584
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0131 0.0529
Loa Loa (eye worm) hypothetical protein 0.0035 0.0104 0.0145
Loa Loa (eye worm) thioredoxin reductase 0.0037 0.0112 0.0156
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0104 0.002
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0148 0.0852 0.0852
Loa Loa (eye worm) hypothetical protein 0.0035 0.0104 0.0145
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0093 0.0483 0.0383
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0303 0.3384
Loa Loa (eye worm) hypothetical protein 0.0055 0.0237 0.0332
Trypanosoma cruzi cysteine peptidase, putative 0.0065 0.0303 0.3384
Schistosoma mansoni coup transcription factor 0.0118 0.0648 0.0733
Schistosoma mansoni transcription factor btf3 0.0039 0.0131 0.0148
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0118 0.0648 0.0648
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0055 0.0237 0.0548
Echinococcus multilocularis zinc finger protein 0.0028 0.0056 0.0056
Loa Loa (eye worm) bromodomain containing protein 0.0023 0.0019 0.0027
Schistosoma mansoni nuclear hormone receptor 0.0055 0.0237 0.0268
Leishmania major cathepsin L-like protease 0.0065 0.0303 0.3384
Brugia malayi hypothetical protein 0.1101 0.7154 1
Loa Loa (eye worm) glutathione reductase 0.0037 0.0112 0.0156
Brugia malayi Ubiquitin conjugating enzyme protein 13 0.0037 0.0118 0.012
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0118 0.0648 0.0733
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0118 0.0648 0.0865
Loa Loa (eye worm) hypothetical protein 0.0446 0.2819 0.3941
Brugia malayi Bromodomain containing protein 0.0045 0.0166 0.0188
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0118 0.0648 0.0906
Loa Loa (eye worm) hypothetical protein 0.0104 0.0558 0.078
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0104 0.0117
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0275 0.0311
Trichomonas vaginalis mitotic inducer phosphatase CDC25, putative 0.0113 0.0616 1
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0033 0.0087 0.0099
Brugia malayi Nuclear hormone receptor E75 0.0055 0.0237 0.0288
Trypanosoma cruzi cytochrome P450, putative 0.0032 0.0084 0.0649
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0145 0.0831 1
Onchocerca volvulus 0.0049 0.0192 0.0384
Brugia malayi nuclear receptor NHR-88 0.0055 0.0237 0.0288
Brugia malayi orphan nuclear receptor NR2E1 0.0055 0.0237 0.0288
Schistosoma mansoni thyroid hormone receptor 0.0503 0.32 0.3617
Schistosoma mansoni hypothetical protein 0.0412 0.2594 0.2932
Schistosoma mansoni mixed-lineage leukemia protein mll 0.013 0.073 0.0825
Loa Loa (eye worm) hypothetical protein 0.0055 0.0237 0.0332
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0347 0.2168 0.2168
Brugia malayi nuclear hormone receptor 0.0118 0.0648 0.0865
Loa Loa (eye worm) ubiquitin conjugating enzyme protein 13 0.0037 0.0118 0.0164
Schistosoma mansoni microtubule-associated protein tau 0.1357 0.8847 1
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0061 0.0275 0.0384
Leishmania major ubiquitin-conjugating enzyme e2, putative 0.0037 0.0118 0.1069
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0309 0.1914 0.2676
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.0037 0.0118 0.0271
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0055 0.0237 0.0332
Brugia malayi cytoplasmic intermediate filament protein 0.0028 0.0057 0.0035
Schistosoma mansoni hypothetical protein 0.0033 0.0087 0.0099
Loa Loa (eye worm) hypothetical protein 0.0055 0.0237 0.0332
Mycobacterium ulcerans hypothetical protein 0.0035 0.0104 0.002
Echinococcus granulosus Nuclear hormone receptor HR96 0.0055 0.0237 0.0237
Loa Loa (eye worm) ubiquitin conjugating enzyme protein 13 0.0037 0.0118 0.0164
Trichomonas vaginalis cdc25c, putative 0.0113 0.0616 1
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0104 0.0104
Loa Loa (eye worm) hypothetical protein 0.0118 0.0648 0.0906
Mycobacterium ulcerans anthranilate phosphoribosyltransferase 0.0432 0.2729 0.2668
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0053 0.0219 0.0306
Loa Loa (eye worm) cytochrome P450 family protein 0.0032 0.0084 0.0117
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0816 0.527 0.527
Toxoplasma gondii ABC1 family protein 0.0035 0.0104 0.1107
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0062 0.0281 0.0281
Onchocerca volvulus 0.0035 0.0104 0.0059
Schistosoma mansoni hypothetical protein 0.0386 0.2422 0.2737
Echinococcus granulosus hydroxymethylglutaryl coenzyme A reductase 0.0136 0.0772 0.0772
Brugia malayi steroid hormone receptor 0.0118 0.0648 0.0865
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0055 0.0237 0.0268
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0055 0.0237 0.0237
Onchocerca volvulus 0.0035 0.0104 0.0059
Entamoeba histolytica hypothetical protein 0.0185 0.1092 1
Loa Loa (eye worm) nuclear hormone receptor 0.0055 0.0237 0.0332
Loa Loa (eye worm) acetyltransferase 0.0148 0.0852 0.1191
Brugia malayi tailless protein 0.0055 0.0237 0.0288
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0104 0.0895
Leishmania major cytochrome p450-like protein 0.0032 0.0084 0.0649
Trypanosoma cruzi cysteine peptidase, putative 0.0065 0.0303 0.3384
Toxoplasma gondii histone lysine methyltransferase SET1 0.0122 0.0679 1
Loa Loa (eye worm) beta-lactamase 0.0035 0.0104 0.0145
Brugia malayi intermediate filament protein 0.0053 0.0219 0.0262
Onchocerca volvulus 0.0053 0.0219 0.048
Echinococcus multilocularis geminin 0.0356 0.2222 0.2222
Brugia malayi latrophilin 2 splice variant baaae 0.0211 0.1268 0.1735
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0098 0.0517 0.0517
Loa Loa (eye worm) hypothetical protein 0.0062 0.0281 0.0393
Schistosoma mansoni hypothetical protein 0.0098 0.0517 0.0584
Loa Loa (eye worm) hypothetical protein 0.1101 0.7154 1
Entamoeba histolytica transcription factor BTF3, putative 0.0039 0.0131 0.0135
Echinococcus multilocularis GPCR, family 2 0.0098 0.0517 0.0517
Brugia malayi photoreceptor-specific nuclear receptor 0.0118 0.0648 0.0865
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0118 0.0648 0.0648
Brugia malayi Latrophilin receptor protein 2 0.0098 0.0517 0.0681
Brugia malayi conserved hypotetical protein 0.0055 0.0237 0.0288
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0093 0.0483 0.0383
Plasmodium vivax hypothetical protein, conserved 0.0033 0.0087 0.3993
Brugia malayi nuclear hormone receptor 0.0055 0.0237 0.0288
Loa Loa (eye worm) hypothetical protein 0.0052 0.0212 0.0297
Brugia malayi Rhodanese-like domain containing protein 0.0113 0.0616 0.082
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0118 0.0648 0.0648
Loa Loa (eye worm) hypothetical protein 0.0056 0.0241 0.0337
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0118 0.0648 0.0865
Brugia malayi Nuclear hormone receptor E75 0.0055 0.0237 0.0288
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0118 0.0648 0.0906
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0118 0.0648 0.0648
Echinococcus granulosus Nuclear hormone receptor HR96 0.0055 0.0237 0.0237
Echinococcus granulosus tar DNA binding protein 0.0061 0.0275 0.0275
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0386 0.2422 0.2422
Echinococcus multilocularis musashi 0.0053 0.0219 0.0219
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0118 0.0648 0.0865
Trypanosoma cruzi cysteine peptidase, putative 0.0065 0.0303 0.3384
Echinococcus granulosus histone acetyltransferase KAT2B 0.0045 0.0171 0.0171
Schistosoma mansoni nuclear hormone receptor 0.0118 0.0648 0.0733
Onchocerca volvulus 0.0167 0.0972 0.3238
Echinococcus multilocularis lamin 0.0053 0.0219 0.0219
Entamoeba histolytica rodhanase-like domain containing protein 0.0113 0.0616 0.512
Brugia malayi F/Y-rich N-terminus family protein 0.0032 0.0078 0.0065
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0473 0.0534
Echinococcus granulosus m phase inducer phosphatasecdc25 0.0113 0.0616 0.0616
Schistosoma mansoni lamin 0.0053 0.0219 0.0247
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0118 0.0648 0.0865
Onchocerca volvulus 0.0053 0.0219 0.048
Loa Loa (eye worm) hypothetical protein 0.0055 0.0237 0.0332
Entamoeba histolytica rodhanase-like domain containing protein 0.0113 0.0616 0.512
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0045 0.0171 0.2143
Brugia malayi Hydroxymethylglutaryl-coenzyme A reductase family protein 0.0136 0.0772 0.1039
Schistosoma mansoni cpg binding protein 0.0067 0.0312 0.0353
Brugia malayi jmjC domain containing protein 0.0108 0.0582 0.0772
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0071 0.0341 0.0341
Brugia malayi hypothetical protein 0.0167 0.0972 0.132
Brugia malayi PHD-finger family protein 0.0033 0.0087 0.0078
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0118 0.0648 0.0865
Trypanosoma cruzi 3-hydroxy-3-methylglutaryl-CoA reductase, putative 0.0136 0.0772 0.926
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0347 0.2168 0.303
Entamoeba histolytica hypothetical protein 0.0185 0.1092 1
Toxoplasma gondii thioredoxin reductase 0.0037 0.0112 0.1233
Loa Loa (eye worm) latrophilin receptor protein 2 0.0098 0.0517 0.0723
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0118 0.0648 0.0648
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0108 0.0582 0.0582
Plasmodium falciparum basic transcription factor 3b, putative 0.0039 0.0131 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0303 0.3384
Entamoeba histolytica acetyltransferase, GNAT family 0.0039 0.013 0.013
Trypanosoma brucei transcription factor BTF3, putative 0.0039 0.0131 0.1234
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0055 0.0237 0.0237
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0118 0.0648 0.0648
Schistosoma mansoni lozenge 0.0056 0.024 0.0271
Loa Loa (eye worm) hypothetical protein 0.0055 0.0237 0.0332
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0055 0.0237 0.0237
Brugia malayi hypothetical protein 0.0446 0.2819 0.3914
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0303 0.3384
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0347 0.2168 0.2999
Echinococcus multilocularis hydroxymethylglutaryl coenzyme A reductase 0.0136 0.0772 0.0772
Brugia malayi follicle stimulating hormone receptor 0.0249 0.1515 0.2082
Echinococcus granulosus cpg binding protein 0.0067 0.0312 0.0312
Echinococcus multilocularis sterol regulatory element binding protein 0.0056 0.0241 0.0241
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0185 0.1092 0.1092
Schistosoma mansoni jumonji/arid domain-containing protein 0.0045 0.017 0.0192
Entamoeba histolytica hypothetical protein 0.0185 0.1092 1
Brugia malayi nuclear receptor RXR 0.0055 0.0237 0.0288
Loa Loa (eye worm) hypothetical protein 0.0062 0.0281 0.0393
Trypanosoma cruzi cytochrome P450, putative 0.0032 0.0084 0.0649
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0118 0.0648 0.0648
Toxoplasma gondii PHD-finger domain-containing protein 0.0033 0.0087 0.0856
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0028 0.0053 0.0053
Echinococcus granulosus lamin 0.0053 0.0219 0.0219
Loa Loa (eye worm) hypothetical protein 0.0055 0.0237 0.0332
Schistosoma mansoni nuclear receptor 0.0055 0.0237 0.0268
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.0064 0.0293 0.3697
Echinococcus granulosus thioredoxin glutathione reductase 0.0037 0.0115 0.0115
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0145 0.0831 0.1162
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0131 0.0529
Trypanosoma cruzi ubiquitin-conjugating enzyme E2, putative 0.0037 0.0118 0.1069
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0118 0.0648 0.0906
Brugia malayi beta-lactamase family protein 0.0035 0.0104 0.01
Onchocerca volvulus 0.0113 0.0616 0.1936
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0098 0.0517 0.0517
Trichomonas vaginalis m-phase inducer phosphatase, putative 0.0113 0.0616 1
Echinococcus granulosus sterol regulatory element binding protein 0.0056 0.0241 0.0241
Onchocerca volvulus 0.0113 0.0616 0.1936
Brugia malayi beta-NAC-like protein 0.0039 0.0131 0.0139
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0309 0.1914 0.2643
Echinococcus granulosus transcription factor Dp 1 0.0084 0.0426 0.0426
Echinococcus granulosus nuclear receptor nhr 48 0.0055 0.0237 0.0237
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0091 0.0473 0.0473
Trypanosoma brucei trypanothione reductase 0.0037 0.0112 0.0997
Trichomonas vaginalis mitotic inducer phosphatase CDC25, putative 0.0113 0.0616 1
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0104 0.0895
Toxoplasma gondii ubiquitin-conjugating enzyme subfamily protein 0.0037 0.0118 0.1322
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0275 0.0311
Echinococcus granulosus tumor protein p63 0.0333 0.2073 0.2073
Loa Loa (eye worm) hypothetical protein 0.0033 0.0087 0.0122
Loa Loa (eye worm) hypothetical protein 0.0035 0.0104 0.0145
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0055 0.0237 0.0237
Toxoplasma gondii PHD-finger domain-containing protein 0.0033 0.0087 0.0856
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0104 0.002
Onchocerca volvulus 0.0061 0.0275 0.0688
Trypanosoma cruzi cruzipain precursor, putative 0.0065 0.0303 0.3384
Brugia malayi Bromodomain containing protein 0.0088 0.0449 0.0586
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0118 0.0648 0.0648
Echinococcus granulosus PHD finger protein rhinoceros 0.0033 0.0087 0.0087
Brugia malayi nuclear receptor NHR-67 0.0055 0.0237 0.0288
Brugia malayi CHE-14 protein 0.0056 0.0241 0.0294
Echinococcus multilocularis FTZ F1 alpha 0.0118 0.0648 0.0648
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0275 0.0311
Loa Loa (eye worm) hypothetical protein 0.0062 0.0281 0.0393
Plasmodium vivax glutathione reductase, putative 0.0037 0.0112 0.5754
Brugia malayi jmjC domain containing protein 0.0045 0.017 0.0193
Echinococcus granulosus zinc finger protein 0.0028 0.0056 0.0056
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0118 0.0648 0.0865
Loa Loa (eye worm) hypothetical protein 0.0055 0.0237 0.0332
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0303 0.3384
Schistosoma mansoni hypothetical protein 0.0185 0.1092 0.1234
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0091 0.0473 0.0473
Brugia malayi TAR-binding protein 0.0061 0.0275 0.0341
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0045 0.0171 0.1307
Giardia lamblia Histone acetyltransferase GCN5 0.0039 0.013 0.2078
Trypanosoma brucei ubiquitin-protein ligase, putative 0.0037 0.0118 0.1069
Loa Loa (eye worm) hypothetical protein 0.0113 0.0616 0.0862
Mycobacterium ulcerans thymidine phosphorylase 0.1531 1 1
Trypanosoma cruzi trypanothione reductase, putative 0.0037 0.0112 0.0997
Toxoplasma gondii NAC domain-containing protein 0.0039 0.0131 0.1526
Loa Loa (eye worm) hypothetical protein 0.0062 0.0281 0.0393
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0386 0.2422 0.2422
Loa Loa (eye worm) hypothetical protein 0.0024 0.0032 0.0045
Schistosoma mansoni nuclear receptor 0.0055 0.0237 0.0268
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0045 0.0171 1
Brugia malayi hypothetical protein 0.0055 0.0237 0.0288
Loa Loa (eye worm) hypothetical protein 0.0076 0.0372 0.052
Echinococcus multilocularis tumor protein p63 0.0333 0.2073 0.2073
Loa Loa (eye worm) hypothetical protein 0.0104 0.0558 0.078
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0118 0.0648 0.0865
Entamoeba histolytica rodhanase-like domain containing protein 0.0113 0.0616 0.512
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0083 0.0422 0.1211
Trichomonas vaginalis cdc25b, putative 0.0113 0.0616 1
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0055 0.0237 0.0237
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0083 0.0422 0.0321
Echinococcus granulosus thyroid hormone receptor alpha 0.0055 0.0237 0.0237
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0145 0.0831 1
Echinococcus multilocularis cpg binding protein 0.0067 0.0312 0.0312
Brugia malayi CXXC zinc finger family protein 0.0061 0.0275 0.0342
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0118 0.0648 0.0906
Toxoplasma gondii aldehyde dehydrogenase 0.012 0.0664 0.9774
Schistosoma mansoni hypothetical protein 0.0022 0.0017 0.0019
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0104 0.0895
Onchocerca volvulus 0.0446 0.2819 1
Mycobacterium ulcerans beta-lactamase 0.0035 0.0104 0.002
Brugia malayi RNA binding protein 0.0061 0.0275 0.0341
Schistosoma mansoni intermediate filament proteins 0.0053 0.0219 0.0247
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0091 0.0473 0.0473
Echinococcus multilocularis microtubule associated protein 2 0.1357 0.8847 0.8847
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0055 0.0237 0.0237
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0118 0.0648 0.0648
Echinococcus granulosus jumonji domain containing protein 0.0046 0.0173 0.0173
Loa Loa (eye worm) hypothetical protein 0.0118 0.0648 0.0906
Brugia malayi Cytochrome P450 family protein 0.0052 0.0212 0.0253
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0091 0.0473 0.0618
Loa Loa (eye worm) RNA binding protein 0.0061 0.0275 0.0384
Echinococcus multilocularis m phase inducer phosphatase(cdc25) 0.0113 0.0616 0.0616
Echinococcus multilocularis transcription factor Dp 1 0.0084 0.0426 0.0426
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0118 0.0648 0.0906
Schistosoma mansoni RAR-like nuclear receptor 0.0118 0.0648 0.0733
Plasmodium vivax ubiquitin-conjugating enzyme E2 N, putative 0.0037 0.0118 0.6168
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0118 0.0648 0.2053
Brugia malayi Steroid receptor seven-up type 2 0.0118 0.0648 0.0865
Trichomonas vaginalis bromodomain-containing protein, putative 0.0045 0.0171 0.1307
Trichomonas vaginalis m-phase inducer phosphatase, putative 0.0113 0.0616 1
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0108 0.0582 0.0582
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0118 0.0648 0.0648
Loa Loa (eye worm) hypothetical protein 0.0049 0.0192 0.0269
Plasmodium falciparum phd finger protein, putative 0.0033 0.0087 0.5608
Schistosoma mansoni jumonji/arid domain-containing protein 0.0045 0.017 0.0192
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.012 0.0664 0.7907
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0045 0.0171 0.2143
Echinococcus multilocularis protein patched 0.0056 0.0241 0.0241
Schistosoma mansoni patched 1 0.0056 0.0241 0.0273
Onchocerca volvulus Bile acid receptor homolog 0.0118 0.0648 0.2053
Plasmodium falciparum histone acetyltransferase GCN5 0.0039 0.013 0.9942
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0055 0.0237 0.0268
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0039 0.0125 0.0125
Echinococcus multilocularis nuclear receptor nhr 48 0.0055 0.0237 0.0237
Loa Loa (eye worm) cytochrome P450 family protein 0.0052 0.0212 0.0297
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0118 0.0648 0.0733
Mycobacterium tuberculosis Probable anthranilate phosphoribosyltransferase TrpD 0.0432 0.2729 0.2653
Onchocerca volvulus 0.0055 0.0237 0.0548
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0091 0.0473 0.0661
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0028 0.0053 0.006
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0145 0.0831 0.7325
Leishmania major basic transcription factor 3a, putative 0.0039 0.0131 0.1234
Leishmania major cathepsin L-like protease 0.0065 0.0303 0.3384
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0118 0.0648 0.0648
Loa Loa (eye worm) nuclear receptor NHR-67 0.0055 0.0237 0.0332
Schistosoma mansoni aldehyde dehydrogenase 0.012 0.0664 0.0751
Brugia malayi nuclear receptor NHR-88 0.0118 0.0648 0.0865
Onchocerca volvulus Protein ultraspiracle homolog 0.0118 0.0648 0.2053
Brugia malayi hypothetical protein 0.0062 0.0281 0.035
Schistosoma mansoni lamin 0.0053 0.0219 0.0247
Trypanosoma brucei 3-hydroxy-3-methylglutaryl-CoA reductase, putative 0.0136 0.0772 0.926
Schistosoma mansoni aldehyde dehydrogenase 0.012 0.0664 0.0751
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.012 0.0664 0.0664
Echinococcus granulosus peregrin 0.0039 0.0128 0.0128
Echinococcus multilocularis thymidine phosphorylase 0.1531 1 1
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0104 0.5164
Loa Loa (eye worm) hypothetical protein 0.0136 0.0772 0.1079
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0055 0.0237 0.0548
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0185 0.1092 0.1092
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0347 0.2168 0.2168
Loa Loa (eye worm) jmjC domain-containing protein 0.0068 0.0319 0.0446
Trypanosoma cruzi transcription factor btf3, putative 0.0039 0.0131 0.1234
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0118 0.0648 0.0865
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0025 0.0038 0.0038
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0093 0.0483 0.1445
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0473 0.0534
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0303 0.3384
Schistosoma mansoni zinc finger protein 0.0055 0.0237 0.0268
Echinococcus multilocularis protein dispatched 1 0.0056 0.0241 0.0241
Entamoeba histolytica hypothetical protein 0.0039 0.0131 0.0135
Loa Loa (eye worm) DR-78 0.0055 0.0237 0.0332
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0104 0.0117
Leishmania major cathepsin L-like protease 0.0065 0.0303 0.3384
Brugia malayi nuclear hormone receptor family member nhr-6 0.0055 0.0237 0.0288
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0028 0.0057 0.0079
Loa Loa (eye worm) hypothetical protein 0.0041 0.0143 0.0199
Loa Loa (eye worm) runx1 0.0056 0.024 0.0335
Schistosoma mansoni hypothetical protein 0.0098 0.0517 0.0584
Plasmodium falciparum glutathione reductase 0.0037 0.0112 0.808
Plasmodium vivax thioredoxin reductase, putative 0.0037 0.0112 0.5754
Schistosoma mansoni hypothetical protein 0.0356 0.2222 0.2512
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0056 0.0241 0.0337
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0071 0.0341 0.0341
Echinococcus multilocularis ecdysone induced protein 78C 0.0118 0.0648 0.0648
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0026 0.0042 0.0047
Onchocerca volvulus 0.0113 0.0616 0.1936
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0083 0.0422 0.0321
Echinococcus multilocularis tar DNA binding protein 0.0061 0.0275 0.0275
Echinococcus multilocularis jumonji domain containing protein 0.0046 0.0173 0.0173
Brugia malayi Cytochrome P450 family protein 0.0032 0.0084 0.0073
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0118 0.0648 0.0648
Echinococcus multilocularis transcription factor btf3 0.0039 0.0131 0.0131
Echinococcus granulosus ubiquitin conjugating enzyme E2 N 0.0037 0.0118 0.0118
Brugia malayi Thioredoxin reductase 0.0037 0.0112 0.0112
Schistosoma mansoni hypothetical protein 0.0356 0.2222 0.2512
Onchocerca volvulus 0.0055 0.0237 0.0548
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0303 0.3384
Brugia malayi Nuclear hormone receptor-like 1 0.0062 0.0281 0.035
Loa Loa (eye worm) hypothetical protein 0.0035 0.0104 0.0145
Loa Loa (eye worm) hypothetical protein 0.0098 0.0517 0.0723
Brugia malayi Cytochrome P450 family protein 0.0032 0.0084 0.0073
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0275 0.0311
Loa Loa (eye worm) hypothetical protein 0.0118 0.0648 0.0906
Schistosoma mansoni bromodomain containing protein 0.0075 0.0366 0.0414
Brugia malayi beta-lactamase family protein 0.0035 0.0104 0.01
Brugia malayi acetyltransferase, GNAT family protein 0.0148 0.0852 0.1151
Schistosoma mansoni hypothetical protein 0.0211 0.1268 0.1433
Loa Loa (eye worm) hypothetical protein 0.0055 0.0237 0.0332
Schistosoma mansoni nuclear receptor nhr-48 0.0055 0.0237 0.0268
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0145 0.0831 1
Entamoeba histolytica hypothetical protein 0.0185 0.1092 1
Echinococcus multilocularis PHD finger protein rhinoceros 0.0033 0.0087 0.0087
Schistosoma mansoni zinc finger protein 0.0028 0.0056 0.0063
Loa Loa (eye worm) cytochrome P450 family protein 0.0032 0.0084 0.0117
Echinococcus granulosus transcription factor btf3 0.0039 0.0131 0.0131
Schistosoma mansoni nuclear hormone receptor 0.0055 0.0237 0.0268
Echinococcus granulosus FTZ F1 alpha 0.0118 0.0648 0.0648
Schistosoma mansoni cpg binding protein 0.0061 0.0275 0.0311
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0131 0.0529
Loa Loa (eye worm) hypothetical protein 0.0211 0.1268 0.1772
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0145 0.0831 0.0831
Mycobacterium leprae Probable anthranilate phosphoribosyltransferase TrpD 0.0432 0.2729 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0098 0.0517 0.0681
Brugia malayi Bromodomain containing protein 0.0039 0.0128 0.0134
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0091 0.0473 0.0473
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0148 0.0852 0.0963
Loa Loa (eye worm) ICD-1 protein 0.0039 0.0131 0.0183
Loa Loa (eye worm) PHD-finger family protein 0.0033 0.0087 0.0122
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0118 0.0648 0.0648
Schistosoma mansoni ubiquitin conjugating enzyme 13 0.0037 0.0118 0.0133
Loa Loa (eye worm) hypothetical protein 0.0118 0.0648 0.0906
Brugia malayi nuclear receptor RXR 0.0062 0.0281 0.035
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0303 0.3384
Onchocerca volvulus 0.0035 0.0104 0.0059
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0062 0.0281 0.0318
Loa Loa (eye worm) hypothetical protein 0.0024 0.0032 0.0045
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0118 0.0648 0.0865
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0037 0.0112 0.0008
Brugia malayi hypothetical protein 0.0062 0.0281 0.035
Loa Loa (eye worm) hypothetical protein 0.0309 0.1914 0.2676
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.006 0.0265 0.2914
Loa Loa (eye worm) hypothetical protein 0.0055 0.0237 0.0332
Echinococcus granulosus ecdysone induced protein 78C 0.0118 0.0648 0.0648
Echinococcus multilocularis lysine specific demethylase 5A 0.004 0.0133 0.0133
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0118 0.0648 0.0733
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0062 0.0281 0.0281
Echinococcus multilocularis Niemann Pick C1 protein 0.0056 0.0241 0.0241
Trypanosoma brucei cytochrome P450, putative 0.0032 0.0084 0.0649
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.0037 0.0118 0.0271
Loa Loa (eye worm) hypothetical protein 0.0118 0.0648 0.0906
Plasmodium vivax basic transcription factor 3b, putative 0.0039 0.0131 0.7121
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0118 0.0648 0.0733
Schistosoma mansoni cellular tumor antigen P53 0.0049 0.0192 0.0217
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.012 0.0664 0.0664
Echinococcus multilocularis Protein lozenge 0.0056 0.024 0.024
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0303 0.3384
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0303 0.3384
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.012 0.0664 0.0566
Mycobacterium ulcerans aldehyde dehydrogenase 0.012 0.0664 0.0585
Echinococcus granulosus lysine specific demethylase 5A 0.0045 0.017 0.017
Loa Loa (eye worm) hypothetical protein 0.0118 0.0648 0.0906
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0118 0.0648 0.0733
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0098 0.0517 0.0517
Trichomonas vaginalis mitotic inducer phosphatase CDC25, putative 0.0113 0.0616 1
Trypanosoma cruzi 3-hydroxy-3-methylglutaryl-CoA reductase 0.0136 0.0772 0.926
Loa Loa (eye worm) hypothetical protein 0.0062 0.0281 0.0393
Trypanosoma cruzi transcription factor btf3, putative 0.0039 0.0131 0.1234
Echinococcus granulosus fetal alzheimer antigen falz 0.0028 0.0053 0.0053
Schistosoma mansoni jumonji domain containing protein 0.0086 0.0436 0.0493
Brugia malayi nuclear hormone receptor family member odr-7 0.0055 0.0237 0.0288
Loa Loa (eye worm) TAR-binding protein 0.0061 0.0275 0.0384
Mycobacterium ulcerans lipase LipD 0.0035 0.0104 0.002
Brugia malayi PHD-finger family protein 0.0034 0.0094 0.0086
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0083 0.0422 0.0321
Brugia malayi hypothetical protein 0.0185 0.1092 0.1488
Schistosoma mansoni steroid hormone receptor ad4bp 0.0118 0.0648 0.0733
Mycobacterium tuberculosis Probable thymidine phosphorylase DeoA (tdrpase) (pyrimidine phosphorylase) 0.1531 1 1
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0118 0.0648 0.0865
Echinococcus granulosus microtubule associated protein 2 0.1357 0.8847 0.8847
Echinococcus granulosus intermediate filament protein 0.0053 0.0219 0.0219
Brugia malayi glutathione reductase 0.0037 0.0112 0.0112
Mycobacterium tuberculosis Probable reductase 0.0083 0.0422 0.0321
Brugia malayi ecdysteroid receptor 0.0118 0.0648 0.0865
Brugia malayi hypothetical protein 0.0055 0.0237 0.0288
Echinococcus granulosus lamin dm0 0.0053 0.0219 0.0219
Loa Loa (eye worm) jmjC domain-containing protein 0.0045 0.017 0.0237
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0118 0.0648 0.0865
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0104 0.0104
Schistosoma mansoni retinoic acid receptor RXR 0.0118 0.0648 0.0733
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0249 0.1515 0.2118
Trypanosoma cruzi major cysteine proteinase, putative 0.0051 0.021 0.2226
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0145 0.0831 0.0831
Echinococcus granulosus GPCR family 2 0.0098 0.0517 0.0517
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0118 0.0648 0.0906
Brugia malayi Rhodanese-like domain containing protein 0.0113 0.0616 0.082
Trichomonas vaginalis conserved hypothetical protein 0.0056 0.0241 0.2686
Loa Loa (eye worm) hypothetical protein 0.0035 0.0104 0.0145
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.0064 0.0293 0.3697
Giardia lamblia 3-hydroxy-3-methylglutaryl-coenzyme A reductase 0.0064 0.0293 1
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0118 0.0648 0.0733
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.0064 0.0293 0.3697
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0226 0.1363 0.1272
Plasmodium falciparum thioredoxin reductase 0.0037 0.0112 0.808
Schistosoma mansoni m-phase inducer phosphatase(cdc25) 0.0113 0.0616 0.0697
Brugia malayi beta-lactamase 0.0035 0.0104 0.01
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0039 0.0125 0.0125
Loa Loa (eye worm) hypothetical protein 0.0047 0.0183 0.0256
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0303 0.3384
Loa Loa (eye worm) hypothetical protein 0.0056 0.0243 0.0339
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0118 0.0648 0.0865
Loa Loa (eye worm) steroid hormone receptor 0.0118 0.0648 0.0906
Brugia malayi Nuclear hormone receptor-like 1 0.0118 0.0648 0.0865
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0118 0.0648 0.0865
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0118 0.0648 0.0906
Echinococcus multilocularis thyroid hormone receptor alpha 0.0503 0.32 0.32
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0062 0.0281 0.0318
Loa Loa (eye worm) CYP4Cod1 0.0032 0.0084 0.0117
Trichomonas vaginalis cdc25b, putative 0.0113 0.0616 1
Loa Loa (eye worm) hypothetical protein 0.0053 0.0219 0.0306
Loa Loa (eye worm) hypothetical protein 0.0024 0.0032 0.0045
Echinococcus granulosus Niemann Pick C1 protein 0.0056 0.0241 0.0241
Echinococcus multilocularis ubiquitin conjugating enzyme E2 N 0.0037 0.0118 0.0118
Echinococcus multilocularis lamin dm0 0.0053 0.0219 0.0219
Schistosoma mansoni hydroxymethylglutaryl-CoA reductase (NADPH) 0.0136 0.0772 0.0873
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0025 0.0038 0.0038
Plasmodium falciparum ubiquitin-conjugating enzyme E2 N, putative 0.0037 0.0118 0.8662
Loa Loa (eye worm) hypothetical protein 0.0118 0.0648 0.0906
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0275 0.0311
Echinococcus multilocularis thioredoxin glutathione reductase 0.0037 0.0115 0.0115
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0303 0.3384
Schistosoma mansoni protein tyrosine phosphatase non-receptor type nt1 0.0347 0.2168 0.245
Echinococcus granulosus Protein patched homolog 1 0.0056 0.0241 0.0241
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0145 0.0831 1
Mycobacterium ulcerans hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase 0.0136 0.0772 0.0694

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 4.6 uM Inhibition of human TP purified from placenta ChEMBL. 16337119
IC50 (binding) = 5 uM Inhibition of human TP expressed in V79 cells ChEMBL. 16337119
IC50 (binding) = 6.1 uM Inhibition of Escherichia coli TP ChEMBL. 16337119

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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